                         б

<110>  Ŵѧ
 
<120>  ϻԽ˵ķԼ

<130>  IEC160007PCT

<150>  CN201610034476.6
<151>  2016-01-20

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  279
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  1

Met Thr Thr Thr Arg Thr Glu Arg Asn Phe Ala Gly Ile Gly Asp Val 
1               5                   10                  15      


Arg Ile Val Tyr Asp Val Trp Thr Pro Asp Thr Ala Pro Gln Ala Val 
            20                  25                  30          


Val Val Leu Ala His Gly Leu Gly Glu His Ala Arg Arg Tyr Asp His 
        35                  40                  45              


Val Ala Gln Arg Leu Gly Ala Ala Gly Leu Val Thr Tyr Ala Leu Asp 
    50                  55                  60                  


His Arg Gly His Gly Arg Ser Gly Gly Lys Arg Val Leu Val Arg Asp 
65                  70                  75                  80  


Ile Ser Glu Tyr Thr Ala Asp Phe Asp Thr Leu Val Gly Ile Ala Thr 
                85                  90                  95      


Arg Glu Tyr Pro Gly Cys Lys Arg Ile Val Leu Gly His Ser Met Gly 
            100                 105                 110         


Gly Gly Ile Val Phe Ala Tyr Gly Val Glu Arg Pro Asp Asn Tyr Asp 
        115                 120                 125             


Leu Met Val Leu Ser Ala Pro Ala Val Ala Ala Gln Asp Leu Val Ser 
    130                 135                 140                 


Pro Val Val Ala Val Ala Ala Lys Leu Leu Gly Val Val Val Pro Gly 
145                 150                 155                 160 


Leu Pro Val Gln Glu Leu Asp Phe Thr Ala Ile Ser Arg Asp Pro Glu 
                165                 170                 175     


Val Val Gln Ala Tyr Asn Thr Asp Pro Leu Val His His Gly Arg Val 
            180                 185                 190         


Pro Ala Gly Ile Gly Arg Ala Leu Leu Gln Val Gly Glu Thr Met Pro 
        195                 200                 205             


Arg Arg Ala Pro Ala Leu Thr Ala Pro Leu Leu Val Leu His Gly Thr 
    210                 215                 220                 


Asp Asp Arg Leu Ile Pro Ile Glu Gly Ser Arg Arg Leu Val Glu Cys 
225                 230                 235                 240 


Val Gly Ser Ala Asp Val Gln Leu Lys Glu Tyr Pro Gly Leu Tyr His 
                245                 250                 255     


Glu Val Phe Asn Glu Pro Glu Arg Asn Gln Val Leu Asp Asp Val Val 
            260                 265                 270         


Ala Trp Leu Thr Glu Arg Leu 
        275                 


<210>  2
<211>  852
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  2
ggatccatga ctaccacccg gactgaacgg aatttcgcgg gcatcggcga tgtgcgcatc       60

gtctacgacg tctggacgcc ggacaccgcg ccgcaagcgg tggtcgtgct ggcccatggt      120

ctgggcgagc atgcccgccg ctacgaccat gtcgcgcagc ggctcggcgc ggccggcctg      180

gtcacctatg cgcttgacca ccgcgggcat ggccgctcgg gtggcaaacg ggtgctagtg      240

agagacatct ccgagtacac cgctgacttc gacaccctcg ttgggatcgc cacccgggaa      300

tatcccgggt gcaagcgcat cgtgctcggg cacagcatgg gcggcggcat tgtgttcgct      360

tacggtgtcg aacgtccaga caactacgac ctgatggtgc tttcggcgcc ggcggtggcg      420

gcacaggacc tggtgagccc ggtagtggcg gttgccgcca agcttctggg cgtcgtggtg      480

cccggcctgc cggtgcagga actggatttt actgccatct ctcgcgaccc tgaggtggtc      540

caggcttaca acaccgaccc actcgtgcac cacggacggg ttccggccgg gattggccgc      600

gcgctgctgc aggtgggcga gaccatgccg cggcgagcac cggcattgac cgcgccgctg      660

ctagtgctgc acggcaccga tgaccggctg atccccatcg agggcagccg tcgcctggtc      720

gaatgtgtgg gatcggccga cgtgcagctg aaggagtatc ccgggctgta ccacgaggtg      780

ttcaacgagc cggagcgcaa ccaggtgctc gacgatgtgg tcgcctggct caccgagcgg      840

ttgtaagaat tc                                                          852


<210>  3
<211>  280
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  3

Asp Ala Gly Val Ser Trp Lys Val Tyr Arg Asn Lys Thr Leu Gly Pro 
1               5                   10                  15      


Ile Ser Ser Val Leu Thr Tyr Gly Ser Leu Val Thr Ser Phe Lys Gln 
            20                  25                  30          


Ser Ala Asp Pro Arg Ser Asp Leu Val Arg Phe Gly Val Ala Pro Ser 
        35                  40                  45              


Tyr Pro Ala Ser Phe Ala Ala Asp Val Leu Ala Asn Arg Leu Pro Arg 
    50                  55                  60                  


Val Ser Trp Val Ile Pro Asn Val Leu Glu Ser Glu His Pro Ala Val 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Phe Ala Ile Val Asn Ile Leu Arg Ile Leu 
                85                  90                  95      


Leu Ala Asn Pro Ala Val Trp Glu Lys Thr Ala Leu Ile Val Ser Tyr 
            100                 105                 110         


Asp Glu Asn Gly Gly Phe Phe Asp His Val Val Pro Ala Thr Ala Pro 
        115                 120                 125             


Ala Gly Thr Pro Gly Glu Tyr Val Thr Val Pro Asp Ile Asp Gln Val 
    130                 135                 140                 


Pro Gly Ser Gly Gly Ile Arg Gly Pro Ile Gly Leu Gly Phe Arg Val 
145                 150                 155                 160 


Pro Cys Phe Val Ile Ser Pro Tyr Ser Arg Gly Pro Gln Met Val His 
                165                 170                 175     


Asp Thr Phe Asp His Thr Ser Gln Leu Arg Leu Leu Glu Thr Arg Phe 
            180                 185                 190         


Gly Val Pro Val Pro Asn Leu Thr Ala Trp Arg Arg Ser Val Thr Gly 
        195                 200                 205             


Asp Met Thr Ser Thr Phe Asn Phe Ala Val Pro Pro Asn Ser Ser Trp 
    210                 215                 220                 


Pro Asn Leu Asp Tyr Pro Gly Leu His Ala Leu Ser Thr Val Pro Gln 
225                 230                 235                 240 


Cys Val Pro Asn Ala Ala Leu Gly Thr Ile Asn Arg Gly Ile Pro Tyr 
                245                 250                 255     


Arg Val Pro Asp Pro Gln Ile Met Pro Thr Gln Glu Thr Thr Pro Thr 
            260                 265                 270         


Arg Gly Ile Pro Ser Gly Pro Cys 
        275                 280 


<210>  4
<211>  843
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  4
gatgccggcg tcagctggaa ggtgtatcgc aacaagacac tcgggcccat ctcctcggtt       60

cttacttacg gctcgcttgt gacgtctttc aaacagtcag ccgatcccag gtcagatctt      120

gtccgctttg gcgtggcacc aagctatccc gcgagcttcg cggccgacgt cttagccaat      180

agactgccgc gggtctcctg ggtgattccc aatgttctcg aatccgaaca tcctgcggtt      240

ccagccgcgg ccggggcttt cgcaatcgtc aacatcttaa gaatattgct tgccaatcct      300

gcggtgtggg aaaagacggc gctgatcgtc agctacgacg aaaacggcgg ctttttcgac      360

cacgttgttc ctgctaccgc gccggccggg actcccggcg aatatgtcac ggtgcctgac      420

atcgatcagg tgccgggctc cggcggaata cgcgggccga tcggtttggg ctttcgcgtt      480

ccctgcttcg tcatttcgcc gtacagccgt ggcccgcaga tggttcacga cacgtttgac      540

cacacctcac agctgagatt gctcgaaact cggttcgggg tgccagttcc caacctcacg      600

gcttggcggc gcagtgtgac cggcgacatg acgtcaacgt tcaacttcgc tgtcccgccc      660

aactcatcat ggcccaacct ggattatccc gggctgcacg cgctatcaac ggtgccgcag      720

tgcgtgccca acgcggcgct gggcacgata aaccgtggaa tcccgtatcg ggttcctgat      780

ccacagatca tgcccacgca ggaaaccacg cctacccgtg gtattccgag cggtccgtgc      840

taa                                                                    843


<210>  5
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p1

<400>  5

Met Thr Thr Thr Arg Thr Glu Arg Asn Phe Ala Gly Ile Gly Asp Val 
1               5                   10                  15      


Arg Ile Val Tyr 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p2

<400>  6

Gly Asp Val Arg Ile Val Tyr Asp Val Trp Thr Pro Asp Thr Ala Pro 
1               5                   10                  15      


Gln Ala Val Val 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p3

<400>  7

Thr Ala Pro Gln Ala Val Val Val Leu Ala His Gly Leu Gly Glu His 
1               5                   10                  15      


Ala Arg Arg Tyr 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p4

<400>  8

Gly Glu His Ala Arg Arg Tyr Asp His Val Ala Gln Arg Leu Gly Ala 
1               5                   10                  15      


Ala Gly Leu Val 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p5

<400>  9

Leu Gly Ala Ala Gly Leu Val Thr Tyr Ala Leu Asp His Arg Gly His 
1               5                   10                  15      


Gly Arg Ser Gly 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p6

<400>  10

Arg Gly His Gly Arg Ser Gly Gly Lys Arg Val Leu Val Arg Asp Ile 
1               5                   10                  15      


Ser Glu Tyr Thr 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p7

<400>  11

Arg Asp Ile Ser Glu Tyr Thr Ala Asp Phe Asp Thr Leu Val Gly Ile 
1               5                   10                  15      


Ala Thr Arg Glu 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p8

<400>  12

Val Gly Ile Ala Thr Arg Glu Tyr Pro Gly Cys Lys Arg Ile Val Leu 
1               5                   10                  15      


Gly His Ser Met 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p9

<400>  13

Ile Val Leu Gly His Ser Met Gly Gly Gly Ile Val Phe Ala Tyr Gly 
1               5                   10                  15      


Val Glu Arg Pro 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p10

<400>  14

Ala Tyr Gly Val Glu Arg Pro Asp Asn Tyr Asp Leu Met Val Leu Ser 
1               5                   10                  15      


Ala Pro Ala Val 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p11

<400>  15

Val Leu Ser Ala Pro Ala Val Ala Ala Gln Asp Leu Val Ser Pro Val 
1               5                   10                  15      


Val Ala Val Ala 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p12

<400>  16

Ser Pro Val Val Ala Val Ala Ala Lys Leu Leu Gly Val Val Val Pro 
1               5                   10                  15      


Gly Leu Pro Val 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p13

<400>  17

Val Val Pro Gly Leu Pro Val Gln Glu Leu Asp Phe Thr Ala Ile Ser 
1               5                   10                  15      


Arg Asp Pro Glu 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p14

<400>  18

Ala Ile Ser Arg Asp Pro Glu Val Val Gln Ala Tyr Asn Thr Asp Pro 
1               5                   10                  15      


Leu Val His His 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p15

<400>  19

Thr Asp Pro Leu Val His His Gly Arg Val Pro Ala Gly Ile Gly Arg 
1               5                   10                  15      


Ala Leu Leu Gln 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p16

<400>  20

Ile Gly Arg Ala Leu Leu Gln Val Gly Glu Thr Met Pro Arg Arg Ala 
1               5                   10                  15      


Pro Ala Leu Thr 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p17

<400>  21

Arg Arg Ala Pro Ala Leu Thr Ala Pro Leu Leu Val Leu His Gly Thr 
1               5                   10                  15      


Asp Asp Arg Leu 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p18

<400>  22

His Gly Thr Asp Asp Arg Leu Ile Pro Ile Glu Gly Ser Arg Arg Leu 
1               5                   10                  15      


Val Glu Cys Val 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p19

<400>  23

Arg Arg Leu Val Glu Cys Val Gly Ser Ala Asp Val Gln Leu Lys Glu 
1               5                   10                  15      


Tyr Pro Gly Leu 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p20

<400>  24

Leu Lys Glu Tyr Pro Gly Leu Tyr His Glu Val Phe Asn Glu Pro Glu 
1               5                   10                  15      


Arg Asn Gln Val 
            20  


<210>  25
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  RV0183-p21

<400>  25

Glu Pro Glu Arg Asn Gln Val Leu Asp Asp Val Val Ala Trp Leu Thr 
1               5                   10                  15      


Glu Arg Leu 
            


<210>  26
<211>  23
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  26
ttcaaccatc gccgcctcta cca                                               23


<210>  27
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  27
ccatcgccgc ctctaccagt                                                   20


<210>  28
<211>  23
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  28
ggatccatgg atgccggcgt cag                                               23


<210>  29
<211>  23
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  29
aagcttttag cacggaccgc tcg                                               23


