                         SEQUENCE LISTING

<110>  University of Pennsylvania
       Choi, Yongwon
       Lee, Soo Young
       Park, Doo Ri
 
<120>  METHODS AND USES OF OSTEOCLAST ASSOCIATED RECEPTOR (OSCAR) FOR 
       PREVENTION AND TREATMENT OF OSTEOARTHRITIS

<130>  046483-7145WO1(01251)

<150>  62/277,894
<151>  2016-01-12

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr 
        35                  40                  45              


Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp 
    50                  55                  60                  


Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg 
65                  70                  75                  80  


Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro 
                85                  90                  95      


Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly 
            100                 105                 110         


Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr 
        115                 120                 125             


Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val 
    130                 135                 140                 


Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn 
145                 150                 155                 160 


Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr 
                165                 170                 175     


Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg 
            180                 185                 190         


Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr 
        195                 200                 205             


Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser 
    210                 215                 220                 


Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Leu Val Leu Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp Arg 
                245                 250                 255     


Ser Gln Asn Arg Ala Pro Ala Gly Ile Arg Pro 
            260                 265         


<210>  2
<211>  265
<212>  PRT
<213>  Mus Musculus

<400>  2

Met Val Leu Ser Leu Ile Leu Gln Leu Ser Thr Leu Trp Pro Ala Cys 
1               5                   10                  15      


Arg Ala Asp Phe Thr Pro Thr Ala Pro Leu Ala Ser Tyr Pro Gln Pro 
            20                  25                  30          


Trp Leu Gly Ala His Pro Ala Ala Val Val Thr Pro Gly Ile Asn Val 
        35                  40                  45              


Thr Leu Thr Cys Arg Ala Pro Gln Ser Ala Trp Arg Phe Ala Leu Phe 
    50                  55                  60                  


Lys Ser Gly Leu Val Thr Pro Leu Leu Leu Arg Asp Val Ser Val Glu 
65                  70                  75                  80  


Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly Ser 
                85                  90                  95      


Tyr His Cys Arg Tyr Arg Lys Thr Asp Trp Gly Pro Gly Val Trp Ser 
            100                 105                 110         


Gln Pro Ser Asn Val Leu Glu Leu Leu Val Thr Asp Gln Leu Pro Arg 
        115                 120                 125             


Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Ala Pro Gly Ala Asn 
    130                 135                 140                 


Val Ser Leu Arg Cys Ala Gly Arg Ile Pro Gly Met Ser Phe Ala Leu 
145                 150                 155                 160 


Tyr Arg Val Gly Val Ala Thr Pro Leu Gln Tyr Ile Asp Ser Val Gln 
                165                 170                 175     


Pro Trp Ala Asp Phe Leu Leu Ile Gly Thr His Thr Pro Gly Thr Tyr 
            180                 185                 190         


Cys Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln Arg 
        195                 200                 205             


Ser Gln Pro Leu Val Ile Ser Phe Glu Gly Ser Gly Ser Leu Asp Tyr 
    210                 215                 220                 


Thr Gln Gly Asn Leu Ile Arg Leu Gly Leu Ala Gly Met Val Leu Ile 
225                 230                 235                 240 


Cys Leu Gly Ile Ile Val Thr Cys Asp Trp His Ser Arg Ser Ser Ala 
                245                 250                 255     


Phe Asp Gly Leu Leu Pro Gln Gln Asn 
            260                 265 


<210>  3
<211>  278
<212>  PRT
<213>  Canis lupus familiaris

<400>  3

Met Ala Leu Ala Leu Ile Leu Glu Leu Leu Ile Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Ser Asp Ile Thr Pro Thr Val Thr Arg Ile Val Ser Pro Ala Leu 
            20                  25                  30          


Tyr Pro Lys Pro Trp Leu Glu Ala Gln Pro Ala Ala Ile Val Thr Pro 
        35                  40                  45              


Gly Val Asn Val Thr Leu Arg Cys Gln Ala Pro Gln Leu Ala Trp Arg 
    50                  55                  60                  


Phe Ala Leu Phe Lys Ser Gly Glu Ile Thr Pro Val Leu Tyr Arg Asp 
65                  70                  75                  80  


Val Ser Met Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala 
                85                  90                  95      


Gln Gly Gly Ser Tyr His Cys Cys Tyr Arg Ser Leu Gly Trp Asp Leu 
            100                 105                 110         


Gly Ile Trp Ser His Pro Ser Asp Thr Leu Glu Leu Leu Val Thr Asp 
        115                 120                 125             


Gln Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Ala 
    130                 135                 140                 


Pro Asp Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Gly Met 
145                 150                 155                 160 


Ser Phe Ala Leu Tyr Arg Val Gly Val Ala Ala Pro Leu Gln Tyr Arg 
                165                 170                 175     


Asp Ser Ala Glu Pro Trp Ala Asp Phe Pro Leu Pro Gly Ala Arg Ala 
            180                 185                 190         


Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ser Pro Tyr Val 
        195                 200                 205             


Leu Ser Leu Arg Ser Glu Pro Leu Val Ile Ser Ala Asp Gly Ser Gly 
    210                 215                 220                 


Ser Leu Asp Tyr Thr Gln Ser Asn Leu Val Arg Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Leu Val Leu Ile Ser Leu Gly Thr Leu Val Val Phe Asp Trp His Ser 
                245                 250                 255     


Gln Ser Arg Thr Gln Ala Ala Ser Gly Pro Glu Pro Gln Arg Thr Gly 
            260                 265                 270         


Tyr Arg Cys Leu Gln Val 
        275             


<210>  4
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220         


<210>  5
<211>  10
<212>  PRT
<213>  Linaria vulgaris

<400>  5

Gly Gln Ala Gly Gln Glu Pro Lys Ser Ser 
1               5                   10  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  7
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro 
            20                  25                  30          


Ala Ser Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val 
        35                  40                  45              


Val Thr Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro 
    50                  55                  60                  


Ala Trp Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu 
65                  70                  75                  80  


Phe Arg Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val 
                85                  90                  95      


Thr Pro Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp 
            100                 105                 110         


Trp Gly Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu 
        115                 120                 125             


Val Thr Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro 
    130                 135                 140                 


Val Val Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu 
145                 150                 155                 160 


Arg Asn Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu 
                165                 170                 175     


Gln Tyr Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly 
            180                 185                 190         


Ala Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala 
        195                 200                 205             


Pro Tyr Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu 
    210                 215                 220                 


Asp Ser Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly 
225                 230                 235                 240 


Leu Ala Gly Leu Val Gly Gln Ala Gly Gln Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475         


<210>  8
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  8

Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser Tyr His 
1               5                   10                  15      


Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly 
            20                  25                  30          


Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe 
        35                  40                  45              


Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val 
    50                  55                  60                  


Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln 
65                  70                  75                  80  


Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly 
                85                  90                  95      


Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu 
            100                 105                 110         


Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro 
        115                 120                 125             


Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser 
    130                 135                 140                 


Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His 
145                 150                 155                 160 


Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro 
                165                 170                 175     


Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu 
            180                 185                 190         


Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser Gly Ser 
        195                 200                 205             


Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala Gly Leu 
    210                 215                 220                 


Val 
225 


<210>  9
<211>  1449
<212>  DNA
<213>  Homo Sapiens

<400>  9
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg gtcgactggt       60

gacatcactc cgtctgtggc cattatagtc cccccagctt cataccaccc taagccatgg      120

ctgggagctc agccggctac agttgtgacc cctggggtca acgtgacctt gagatgccgg      180

gcaccccaac ccgcttggag atttggactt ttcaagcctg gagagatcgc tccccttctc      240

ttccgggatg tgtcctccga gctggcagaa ttctttctgg aggaggtgac tccagcccaa      300

gggggaagtt accgctgctg ctaccgaagg ccagactggg ggccgggtgt ctggtcccag      360

cccagcgatg tcctggagct gctggtgaca gaggagctgc cgcggccgtc gctggtggcg      420

ctgcccgggc cggtggtggg tcctggcgcc aacgtgagcc tgcgctgcgc gggccgcctg      480

cggaacatga gcttcgtgct gtaccgcgag ggcgtggcgg ccccgctgca gtaccgccac      540

tccgcgcagc cctgggccga cttcacgctg ctgggcgccc gcgcccccgg cacctacagc      600

tgctactatc acacgccctc cgcgccctac gtgctgtcgc agcgcagcga ggtgctggtc      660

atcagctggg aagactctgg ctcctccgac tacacccggg ggaacctagt ccgcctgggg      720

ctggccgggc tggtcggcca ggccggccag gagcccaaat ctagcgacaa aactcacaca      780

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      840

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      900

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      960

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1020

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1080

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1140

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1200

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1260

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1320

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1380

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtccccg     1440

ggtaaatga                                                             1449


<210>  10
<211>  1566
<212>  DNA
<213>  Canis lupus familiaris

<400>  10
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg gtcgactggt       60

gacatcactc caactgtgac caggatagtc tccccagcct tataccccaa gccatggctg      120

gaggctcagc ctgctgcaat tgtaacccct ggggtcaacg tgaccttgag gtgccaggca      180

cctcaacttg cctggaggtt tgcactcttc aagtctggag aaatcactcc tgtgctgtac      240

cgggatgtgt ccatggagct ggcagagttc ttcctggagg aggtgacccc agcccagggg      300

ggcagttacc actgctgcta ccggagtctt ggctgggacc tgggtatctg gtcccacccc      360

agtgatacac tggaactgct ggtgacagac cagctgccgc gcccgtcgct cgtggcgctg      420

cccgggccgg tggtggcgcc cgatgccaac gtgagcctgc gctgcgccgg ccgcctgcgg      480

ggcatgagct tcgcgctgta ccgcgtgggg gtggcggcgc cgctgcagta ccgcgactcg      540

gcggagccct gggccgactt cccgctgccc ggagcccgcg cgccgggcac ctacagctgc      600

tactaccaca cgccgtcctc cccgtacgtg ctgtcgctgc gcagcgagcc gctggtcatc      660

agcgctgacg gctcaggctc cttggactac actcagagca acctcgtccg cctggggttg      720

gctggcctgg tcctcatctc cctgggcaca ctggttgttt ttgactggca cagccagagt      780

cgcacccagg cagcgtcagg ccctgagccc cagaggactg gatacagatg cctccaagtc      840

ggatccccca aaagagaaaa tggaagagtt cctcgcccac ctgattgtcc caaatgccca      900

gcccctgaaa tgctgggagg gccttcggtc ttcatctttc ccccgaaacc caaggacacc      960

ctcttgattg cccgaacacc tgaggtcaca tgtgtggtgg tggatctgga cccagaagac     1020

cctgaggtgc agatcagctg gttcgtggac ggtaagcaga tgcaaacagc caagactcag     1080

cctcgtgagg agcagttcaa tggcacctac cgtgtggtca gtgtcctccc cattgggcac     1140

caggactggc tcaaggggaa gcagttcacg tgcaaagtca acaacaaagc cctcccatcc     1200

ccgatcgaga ggaccatctc caaggccaga gggcaggccc atcaacccag tgtgtatgtc     1260

ctgccgccat cccgggagga gttgagcaag aacacagtca gcttgacatg cctgatcaaa     1320

gacttcttcc cacctgacat tgatgtggag tggcagagca atggacagca ggagcctgag     1380

agcaagtacc gcacgacccc gccccagctg gacgaggacg ggtcctactt cctgtacagc     1440

aagctctctg tggacaagag ccgctggcag cggggagaca ccttcatatg tgcggtgatg     1500

catgaagctc tacacaacca ctacacacag gaatccctct cccattctcc gggtaaatga     1560

ggccgc                                                                1566


<210>  11
<211>  512
<212>  PRT
<213>  Canis lupus familiaris

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Thr Pro Thr Val Thr Arg Ile Val Ser Pro 
            20                  25                  30          


Ala Leu Tyr Pro Lys Pro Trp Leu Glu Ala Gln Pro Ala Ala Ile Val 
        35                  40                  45              


Thr Pro Gly Val Asn Val Thr Leu Arg Cys Gln Ala Pro Gln Leu Ala 
    50                  55                  60                  


Trp Arg Phe Ala Leu Phe Lys Ser Gly Glu Ile Thr Pro Val Leu Tyr 
65                  70                  75                  80  


Arg Asp Val Ser Met Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr 
                85                  90                  95      


Pro Ala Gln Gly Gly Ser Tyr His Cys Cys Tyr Arg Ser Leu Gly Trp 
            100                 105                 110         


Asp Leu Gly Ile Trp Ser His Pro Ser Asp Thr Leu Glu Leu Leu Val 
        115                 120                 125             


Thr Asp Gln Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val 
    130                 135                 140                 


Val Ala Pro Asp Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg 
145                 150                 155                 160 


Gly Met Ser Phe Ala Leu Tyr Arg Val Gly Val Ala Ala Pro Leu Gln 
                165                 170                 175     


Tyr Arg Asp Ser Ala Glu Pro Trp Ala Asp Phe Pro Leu Pro Gly Ala 
            180                 185                 190         


Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ser Pro 
        195                 200                 205             


Tyr Val Leu Ser Leu Arg Ser Glu Pro Leu Val Ile Ser Ala Asp Gly 
    210                 215                 220                 


Ser Gly Ser Leu Asp Tyr Thr Gln Ser Asn Leu Val Arg Leu Gly Leu 
225                 230                 235                 240 


Ala Gly Leu Val Leu Ile Ser Leu Gly Thr Leu Val Val Phe Asp Trp 
                245                 250                 255     


His Ser Gln Ser Arg Thr Gln Ala Ala Ser Gly Pro Glu Pro Gln Arg 
            260                 265                 270         


Thr Gly Tyr Arg Cys Leu Gln Val Gly Ser Pro Lys Ile Glu Asn Gly 
        275                 280                 285             


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Ile Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile 
                325                 330                 335     


Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro 
            340                 345                 350         


Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro 
        355                 360                 365             


Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val 
    370                 375                 380                 


Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg 
                405                 410                 415     


Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp 
            420                 425                 430         


Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln 
        435                 440                 445             


Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp 
    450                 455                 460                 


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Gly Ala 
            500                 505                 510         


