                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       DIKSTEIN, Rivka
       ASHKENAZI, Shaked
 
<120>  NF-kappaB INHIBITORS

<130>  68614

<150>  US 62/277,498
<151>  2016-01-12

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly 
                405                 410                 415     


Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly 
            420                 425                 430         


Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu 
        435                 440                 445             


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr 
    450                 455                 460                 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
465                 470                 475                 480 


Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr 
                485                 490                 495     


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp 
            500                 505                 510         


Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu 
        515                 520                 525             


Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala 
    530                 535                 540                 


Leu Leu Ser Gln Ile Ser Ser 
545                 550     


<210>  2
<211>  298
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(298)
<223>  Amino acids 1-298 of p65/RelA   (SEQ ID NO: 1)

<400>  2

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile 
    290                 295             


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  3

Gly Gly Gly Gly Ser 
1               5   


<210>  4
<211>  311
<212>  PRT
<213>  Renilla reniformis

<400>  4

Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln 
305                 310     


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding protein linker (SEQ ID NO: 3)

<400>  5
ggtggcggag ggagc                                                        15


<210>  6
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Gly Ala Tyr Asn Pro Tyr Ile Glu Ile Ile Glu Gln Pro 
1               5                   10                  15      


Arg Gln Arg Gly Met Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala 
            20                  25                  30          


Gly Ser Ile Pro Gly Glu His Ser Thr Asp Asn Asn Arg Thr Tyr Pro 
        35                  40                  45              


Ser Ile Gln Ile Met Asn Tyr Tyr Gly Lys Gly Lys Val Arg Ile Thr 
    50                  55                  60                  


Leu Val Thr Lys Asn Asp Pro Tyr Lys Pro His Pro His Asp Leu Val 
65                  70                  75                  80  


Gly Lys Asp Cys Arg Asp Gly Tyr Tyr Glu Ala Glu Phe Gly Gln Glu 
                85                  90                  95      


Arg Arg Pro Leu Phe Phe Gln Asn Leu Gly Ile Arg Cys Val Lys Lys 
            100                 105                 110         


Lys Glu Val Lys Glu Ala Ile Ile Thr Arg Ile Lys Ala Gly Ile Asn 
        115                 120                 125             


Pro Phe Asn Val Pro Glu Lys Gln Leu Asn Asp Ile Glu Asp Cys Asp 
    130                 135                 140                 


Leu Asn Val Val Arg Leu Cys Phe Gln Val Phe Leu Pro Asp Glu His 
145                 150                 155                 160 


Gly Asn Leu Thr Thr Ala Leu Pro Pro Val Val Ser Asn Pro Ile Tyr 
                165                 170                 175     


Asp Asn Arg Ala Pro Asn Thr Ala Glu Leu Arg Ile Cys Arg Val Asn 
            180                 185                 190         


Lys Asn Cys Gly Ser Val Arg Gly Gly Asp Glu Ile Phe Leu Leu Cys 
        195                 200                 205             


Asp Lys Val Gln Lys Asp Asp Ile Glu Val Arg Phe Val Leu Asn Asp 
    210                 215                 220                 


Trp Glu Ala Lys Gly Ile Phe Ser Gln Ala Asp Val His Arg Gln Val 
225                 230                 235                 240 


Ala Ile Val Phe Lys Thr Pro Pro Tyr Cys Lys Ala Ile Thr Glu Pro 
                245                 250                 255     


Val Thr Val Lys Met Gln Leu Arg Arg Pro Ser Asp Gln Glu Val Ser 
            260                 265                 270         


Glu Ser Met Asp Phe Arg Tyr Leu Pro Asp Glu Lys Asp Thr Tyr Gly 
        275                 280                 285             


Asn Lys Ala Lys Lys Gln Lys Thr Thr Leu Leu Phe Gln Lys Leu Cys 
    290                 295                 300                 


Gln Asp His Val Glu Thr Gly Phe Arg His Val Asp Gln Asp Gly Leu 
305                 310                 315                 320 


Glu Leu Leu Thr Ser Gly Asp Pro Pro Thr Leu Ala Ser Gln Ser Ala 
                325                 330                 335     


Gly Ile Thr Val Asn Phe Pro Glu Arg Pro Arg Pro Gly Leu Leu Gly 
            340                 345                 350         


Ser Ile Gly Glu Gly Arg Tyr Phe Lys Lys Glu Pro Asn Leu Phe Ser 
        355                 360                 365             


His Asp Ala Val Val Arg Glu Met Pro Thr Gly Val Ser Ser Gln Ala 
    370                 375                 380                 


Glu Ser Tyr Tyr Pro Ser Pro Gly Pro Ile Ser Ser Gly Leu Ser His 
385                 390                 395                 400 


His Ala Ser Met Ala Pro Leu Pro Ser Ser Ser Trp Ser Ser Val Ala 
                405                 410                 415     


His Pro Thr Pro Arg Ser Gly Asn Thr Asn Pro Leu Ser Ser Phe Ser 
            420                 425                 430         


Thr Arg Thr Leu Pro Ser Asn Ser Gln Gly Ile Pro Pro Phe Leu Arg 
        435                 440                 445             


Ile Pro Val Gly Asn Asp Leu Asn Ala Ser Asn Ala Cys Ile Tyr Asn 
    450                 455                 460                 


Asn Ala Asp Asp Ile Val Gly Met Glu Ala Ser Ser Met Pro Ser Ala 
465                 470                 475                 480 


Asp Leu Tyr Gly Ile Ser Asp Pro Asn Met Leu Ser Asn Cys Ser Val 
                485                 490                 495     


Asn Met Met Thr Thr Ser Ser Asp Ser Met Gly Glu Thr Asp Asn Pro 
            500                 505                 510         


Arg Leu Leu Ser Met Asn Leu Glu Asn Pro Ser Cys Asn Ser Val Leu 
        515                 520                 525             


Asp Pro Arg Asp Leu Arg Gln Leu His Gln Met Ser Ser Ser Ser Met 
    530                 535                 540                 


Ser Ala Gly Ala Asn Ser Asn Thr Thr Val Phe Val Ser Gln Ser Asp 
545                 550                 555                 560 


Ala Phe Glu Gly Ser Asp Phe Ser Cys Ala Asp Asn Ser Met Ile Asn 
                565                 570                 575     


Glu Ser Gly Pro Ser Asn Ser Thr Asn Pro Asn Ser His Gly Phe Val 
            580                 585                 590         


Gln Asp Ser Gln Tyr Ser Gly Ile Gly Ser Met Gln Asn Glu Gln Leu 
        595                 600                 605             


Ser Asp Ser Phe Pro Tyr Glu Phe Phe Gln Val 
    610                 615                 


<210>  7
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Arg Ser Gly Pro Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      


Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Pro Glu Leu 
            20                  25                  30          


Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              


Arg Ser Thr Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn 
    50                  55                  60                  


Gly Phe Gly Leu Asp Gly Gly Gln Pro Gly Pro Gly Glu Gly Leu Pro 
65                  70                  75                  80  


Arg Leu Val Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly 
                85                  90                  95      


Pro Val Ala Pro Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly 
            100                 105                 110         


Arg Leu Val Ser Pro Ala Pro Gly Pro Gly Pro Gln Pro His Leu Val 
        115                 120                 125             


Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys 
    130                 135                 140                 


Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala 
145                 150                 155                 160 


Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg 
                165                 170                 175     


Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg 
            180                 185                 190         


Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Ile Cys 
        195                 200                 205             


Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn 
    210                 215                 220                 


Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu 
225                 230                 235                 240 


Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys 
                245                 250                 255     


Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala 
            260                 265                 270         


Ser Tyr Arg Asp Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu 
        275                 280                 285             


Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg 
    290                 295                 300                 


Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu 
305                 310                 315                 320 


Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val 
                325                 330                 335     


Phe Ser Arg Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp 
            340                 345                 350         


Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp 
        355                 360                 365             


Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu 
    370                 375                 380                 


Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg 
385                 390                 395                 400 


Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro 
                405                 410                 415     


Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser 
            420                 425                 430         


Lys Arg Arg Lys Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Asn 
        435                 440                 445             


His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro 
    450                 455                 460                 


Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly 
465                 470                 475                 480 


Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro 
                485                 490                 495     


Thr Leu Phe Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala 
            500                 505                 510         


Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Thr 
        515                 520                 525             


Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro 
    530                 535                 540                 


Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
545                 550                 555                 560 


His Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
                565                 570                 575     


Glu Ala Thr 
            


<210>  8
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Asp Gly Pro Tyr Leu Gln Ile Leu Glu 
        35                  40                  45              


Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro 
    50                  55                  60                  


Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser 
65                  70                  75                  80  


Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile 
                85                  90                  95      


Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser 
            100                 105                 110         


Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly 
        115                 120                 125             


Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val 
    130                 135                 140                 


Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala 
145                 150                 155                 160 


Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala 
                165                 170                 175     


Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu 
            180                 185                 190         


Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp 
        195                 200                 205             


Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr 
    210                 215                 220                 


Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr 
225                 230                 235                 240 


Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met Asp 
                245                 250                 255     


Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu Cys 
            260                 265                 270         


Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu Glu 
        275                 280                 285             


Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr Asp 
    290                 295                 300                 


Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys Asp 
305                 310                 315                 320 


Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg Lys 
                325                 330                 335     


Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro Glu 
            340                 345                 350         


Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met Pro 
        355                 360                 365             


Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly 
    370                 375                 380                 


Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr 
385                 390                 395                 400 


Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly 
                405                 410                 415     


Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His 
            420                 425                 430         


Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp Lys 
        435                 440                 445             


Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu Thr 
    450                 455                 460                 


Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly Glu 
465                 470                 475                 480 


Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly Val 
                485                 490                 495     


Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg His 
            500                 505                 510         


Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu 
        515                 520                 525             


Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp 
    530                 535                 540                 


Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val Arg 
545                 550                 555                 560 


Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile Asn 
                565                 570                 575     


Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr 
            580                 585                 590         


Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp Leu 
        595                 600                 605             


Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala Lys 
    610                 615                 620                 


Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys Ala 
625                 630                 635                 640 


Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile His 
                645                 650                 655     


Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val Ala 
            660                 665                 670         


Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala 
        675                 680                 685             


Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys Leu 
    690                 695                 700                 


Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly Thr 
705                 710                 715                 720 


Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala 
                725                 730                 735     


Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro 
            740                 745                 750         


Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu Gly 
        755                 760                 765             


Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln Val 
    770                 775                 780                 


Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser Asp 
785                 790                 795                 800 


Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val Lys 
                805                 810                 815     


Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp 
            820                 825                 830         


Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe 
        835                 840                 845             


Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val 
    850                 855                 860                 


Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met Gly 
865                 870                 875                 880 


Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val Lys 
                885                 890                 895     


Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr Arg 
            900                 905                 910         


Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly 
        915                 920                 925             


Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr Ser 
    930                 935                 940                 


Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly Gln 
945                 950                 955                 960 


Glu Gly Pro Leu Glu Gly Lys Ile 
                965             


<210>  9
<211>  900
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Ser Cys Tyr Asn Pro Gly Leu Asp Gly Ile Ile Glu Tyr Asp 
1               5                   10                  15      


Asp Phe Lys Leu Asn Ser Ser Ile Val Glu Pro Lys Glu Pro Ala Pro 
            20                  25                  30          


Glu Thr Ala Asp Gly Pro Tyr Leu Val Ile Val Glu Gln Pro Lys Gln 
        35                  40                  45              


Arg Gly Phe Arg Phe Arg Tyr Gly Cys Glu Gly Pro Ser His Gly Gly 
    50                  55                  60                  


Leu Pro Gly Ala Ser Ser Glu Lys Gly Arg Lys Thr Tyr Pro Thr Val 
65                  70                  75                  80  


Lys Ile Cys Asn Tyr Glu Gly Pro Ala Lys Ile Glu Val Asp Leu Val 
                85                  90                  95      


Thr His Ser Asp Pro Pro Arg Ala His Ala His Ser Leu Val Gly Lys 
            100                 105                 110         


Gln Cys Ser Glu Leu Gly Ile Cys Ala Val Ser Val Gly Pro Lys Asp 
        115                 120                 125             


Met Thr Ala Gln Phe Asn Asn Leu Gly Val Leu His Val Thr Lys Lys 
    130                 135                 140                 


Asn Met Met Gly Thr Met Ile Gln Lys Leu Gln Arg Gln Arg Leu Arg 
145                 150                 155                 160 


Ser Arg Pro Gln Gly Leu Thr Glu Ala Glu Gln Arg Glu Leu Glu Gln 
                165                 170                 175     


Glu Ala Lys Glu Leu Lys Lys Val Met Asp Leu Ser Ile Val Arg Leu 
            180                 185                 190         


Arg Phe Ser Ala Phe Leu Arg Ala Ser Asp Gly Ser Phe Ser Leu Pro 
        195                 200                 205             


Leu Lys Pro Val Ile Ser Gln Pro Ile His Asp Ser Lys Ser Pro Gly 
    210                 215                 220                 


Ala Ser Asn Leu Lys Ile Ser Arg Met Asp Lys Thr Ala Gly Ser Val 
225                 230                 235                 240 


Arg Gly Gly Asp Glu Val Tyr Leu Leu Cys Asp Lys Val Gln Lys Asp 
                245                 250                 255     


Asp Ile Glu Val Arg Phe Tyr Glu Asp Asp Glu Asn Gly Trp Gln Ala 
            260                 265                 270         


Phe Gly Asp Phe Ser Pro Thr Asp Val His Lys Gln Tyr Ala Ile Val 
        275                 280                 285             


Phe Arg Thr Pro Pro Tyr His Lys Met Lys Ile Glu Arg Pro Val Thr 
    290                 295                 300                 


Val Phe Leu Gln Leu Lys Arg Lys Arg Gly Gly Asp Val Ser Asp Ser 
305                 310                 315                 320 


Lys Gln Phe Thr Tyr Tyr Pro Leu Val Glu Asp Lys Glu Glu Val Gln 
                325                 330                 335     


Arg Lys Arg Arg Lys Ala Leu Pro Thr Phe Ser Gln Pro Phe Gly Gly 
            340                 345                 350         


Gly Ser His Met Gly Gly Gly Ser Gly Gly Ala Ala Gly Gly Tyr Gly 
        355                 360                 365             


Gly Ala Gly Gly Gly Gly Ser Leu Gly Phe Phe Pro Ser Ser Leu Ala 
    370                 375                 380                 


Tyr Ser Pro Tyr Gln Ser Gly Ala Gly Pro Met Gly Cys Tyr Pro Gly 
385                 390                 395                 400 


Gly Gly Gly Gly Ala Gln Met Ala Ala Thr Val Pro Ser Arg Asp Ser 
                405                 410                 415     


Gly Glu Glu Ala Ala Glu Pro Ser Ala Pro Ser Arg Thr Pro Gln Cys 
            420                 425                 430         


Glu Pro Gln Ala Pro Glu Met Leu Gln Arg Ala Arg Glu Tyr Asn Ala 
        435                 440                 445             


Arg Leu Phe Gly Leu Ala Gln Arg Ser Ala Arg Ala Leu Leu Asp Tyr 
    450                 455                 460                 


Gly Val Thr Ala Asp Ala Arg Ala Leu Leu Ala Gly Gln Arg His Leu 
465                 470                 475                 480 


Leu Thr Ala Gln Asp Glu Asn Gly Asp Thr Pro Leu His Leu Ala Ile 
                485                 490                 495     


Ile His Gly Gln Thr Ser Val Ile Glu Gln Ile Val Tyr Val Ile His 
            500                 505                 510         


His Ala Gln Asp Leu Gly Val Val Asn Leu Thr Asn His Leu His Gln 
        515                 520                 525             


Thr Pro Leu His Leu Ala Val Ile Thr Gly Gln Thr Ser Val Val Ser 
    530                 535                 540                 


Phe Leu Leu Arg Val Gly Ala Asp Pro Ala Leu Leu Asp Arg His Gly 
545                 550                 555                 560 


Asp Ser Ala Met His Leu Ala Leu Arg Ala Gly Ala Gly Ala Pro Glu 
                565                 570                 575     


Leu Leu Arg Ala Leu Leu Gln Ser Gly Ala Pro Ala Val Pro Gln Leu 
            580                 585                 590         


Leu His Met Pro Asp Phe Glu Gly Leu Tyr Pro Val His Leu Ala Val 
        595                 600                 605             


Arg Ala Arg Ser Pro Glu Cys Leu Asp Leu Leu Val Asp Ser Gly Ala 
    610                 615                 620                 


Glu Val Glu Ala Thr Glu Arg Gln Gly Gly Arg Thr Ala Leu His Leu 
625                 630                 635                 640 


Ala Thr Glu Met Glu Glu Leu Gly Leu Val Thr His Leu Val Thr Lys 
                645                 650                 655     


Leu Arg Ala Asn Val Asn Ala Arg Thr Phe Ala Gly Asn Thr Pro Leu 
            660                 665                 670         


His Leu Ala Ala Gly Leu Gly Tyr Pro Thr Leu Thr Arg Leu Leu Leu 
        675                 680                 685             


Lys Ala Gly Ala Asp Ile His Ala Glu Asn Glu Glu Pro Leu Cys Pro 
    690                 695                 700                 


Leu Pro Ser Pro Pro Thr Ser Asp Ser Asp Ser Asp Ser Glu Gly Pro 
705                 710                 715                 720 


Glu Lys Asp Thr Arg Ser Ser Phe Arg Gly His Thr Pro Leu Asp Leu 
                725                 730                 735     


Thr Cys Ser Thr Lys Val Lys Thr Leu Leu Leu Asn Ala Ala Gln Asn 
            740                 745                 750         


Thr Met Glu Pro Pro Leu Thr Pro Pro Ser Pro Ala Gly Pro Gly Leu 
        755                 760                 765             


Ser Leu Gly Asp Thr Ala Leu Gln Asn Leu Glu Gln Leu Leu Asp Gly 
    770                 775                 780                 


Pro Glu Ala Gln Gly Ser Trp Ala Glu Leu Ala Glu Arg Leu Gly Leu 
785                 790                 795                 800 


Arg Ser Leu Val Asp Thr Tyr Arg Gln Thr Thr Ser Pro Ser Gly Ser 
                805                 810                 815     


Leu Leu Arg Ser Tyr Glu Leu Ala Gly Gly Asp Leu Ala Gly Leu Leu 
            820                 825                 830         


Glu Ala Leu Ser Asp Met Gly Leu Glu Glu Gly Val Arg Leu Leu Arg 
        835                 840                 845             


Gly Pro Glu Thr Arg Asp Lys Leu Pro Ser Thr Ala Glu Val Lys Glu 
    850                 855                 860                 


Asp Ser Ala Tyr Gly Ser Gln Ser Val Glu Gln Glu Ala Glu Lys Leu 
865                 870                 875                 880 


Gly Pro Pro Pro Glu Pro Pro Gly Gly Leu Cys His Gly His Pro Gln 
                885                 890                 895     


Pro Gln Val His 
            900 


<210>  10
<211>  827
<212>  PRT
<213>  Mus musculus

<400>  10

Met Pro Ser Thr Ser Phe Pro Val Pro Ser Lys Phe Pro Leu Gly Pro 
1               5                   10                  15      


Pro Ala Ala Val Cys Gly Ser Gly Glu Thr Leu Arg Pro Ala Pro Pro 
            20                  25                  30          


Ser Gly Gly Thr Met Lys Ala Ala Glu Glu Glu His Tyr Ser Tyr Val 
        35                  40                  45              


Ser Pro Ser Val Thr Ser Thr Leu Pro Leu Pro Thr Ala His Ser Ala 
    50                  55                  60                  


Leu Pro Ala Ala Cys His Asp Leu Gln Thr Ser Thr Pro Gly Ile Ser 
65                  70                  75                  80  


Ala Val Pro Ser Ala Asn His Pro Pro Ser Tyr Gly Gly Ala Val Asp 
                85                  90                  95      


Ser Gly Pro Ser Gly Tyr Phe Leu Ser Ser Gly Asn Thr Arg Pro Asn 
            100                 105                 110         


Gly Ala Pro Thr Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Tyr Leu 
        115                 120                 125             


Gly Leu His His Gly Ser Gly Gln Phe Phe His Asp Val Glu Val Glu 
    130                 135                 140                 


Asp Val Leu Pro Ser Cys Lys Arg Ser Pro Ser Thr Ala Thr Leu His 
145                 150                 155                 160 


Leu Pro Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro Ala 
                165                 170                 175     


Ser Ser Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr Glu 
            180                 185                 190         


Ser Asn Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp Gln 
        195                 200                 205             


Ser Pro Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe Pro 
    210                 215                 220                 


Arg Ser Leu Gly Ala Cys His Leu Leu Gly Ser Pro Arg His Ser Pro 
225                 230                 235                 240 


Ser Thr Ser Pro Arg Ala Ser Ile Thr Glu Glu Ser Trp Leu Gly Ala 
                245                 250                 255     


Arg Gly Ser Arg Pro Thr Ser Pro Cys Asn Lys Arg Lys Tyr Ser Leu 
            260                 265                 270         


Asn Gly Arg Gln Pro Ser Cys Ser Pro His His Ser Pro Thr Pro Ser 
        275                 280                 285             


Pro His Gly Ser Pro Arg Val Ser Val Thr Glu Asp Thr Trp Leu Gly 
    290                 295                 300                 


Asn Thr Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn Ala 
305                 310                 315                 320 


Leu Thr Thr Asp Ser Thr Leu Asp Leu Gly Asp Gly Val Pro Ile Lys 
                325                 330                 335     


Ser Arg Lys Thr Ala Leu Glu His Ala Pro Ser Val Ala Leu Lys Val 
            340                 345                 350         


Glu Pro Ala Gly Glu Asp Leu Gly Thr Thr Pro Pro Thr Ser Asp Phe 
        355                 360                 365             


Pro Pro Glu Glu Tyr Thr Phe Gln His Leu Arg Lys Gly Ala Phe Cys 
    370                 375                 380                 


Glu Gln Tyr Leu Ser Val Pro Gln Ala Ser Tyr Gln Trp Ala Lys Pro 
385                 390                 395                 400 


Lys Ser Leu Ser Pro Thr Ser Tyr Met Ser Pro Ser Leu Pro Ala Leu 
                405                 410                 415     


Asp Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg Ile Glu 
            420                 425                 430         


Val Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu Gly Ser 
        435                 440                 445             


Arg Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val Gln Leu 
    450                 455                 460                 


His Gly Tyr Leu Glu Asn Glu Pro Leu Thr Leu Gln Leu Phe Ile Gly 
465                 470                 475                 480 


Thr Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln Val His 
                485                 490                 495     


Arg Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ile Ile Leu 
            500                 505                 510         


Ser Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn Asn Met 
        515                 520                 525             


Arg Ala Ile Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp 
    530                 535                 540                 


Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg 
545                 550                 555                 560 


Val Arg Leu Val Phe Arg Val His Ile Pro Gln Pro Asn Gly Arg Thr 
                565                 570                 575     


Leu Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser 
            580                 585                 590         


Ala Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser Tyr Pro 
        595                 600                 605             


Val Ile Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe Leu Gln 
    610                 615                 620                 


Asp Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His His Val 
625                 630                 635                 640 


Trp Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro Asn Ser 
                645                 650                 655     


Leu Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr Ser Pro 
            660                 665                 670         


Val Gln Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg Ser Gln 
        675                 680                 685             


Tyr Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile Lys Thr 
    690                 695                 700                 


Glu Pro Thr Asp Asp Phe Glu Pro Ala Leu Thr Cys Gly Pro Met Ser 
705                 710                 715                 720 


Gln Gly Ile Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln Leu Thr 
                725                 730                 735     


Met Pro Pro Asp Pro Gly Ser Cys Leu Val Ala Gly Phe Ala Pro Cys 
            740                 745                 750         


Ser Gln Arg Asn Thr Leu Met Pro Thr Pro Pro Asn Ala Ser Pro Lys 
        755                 760                 765             


Leu His Asp Leu Ser Ser Pro Ala Tyr Thr Lys Gly Leu Thr Asn Pro 
    770                 775                 780                 


Gly His Ser Gly His Leu Gly Leu Gln Pro Pro Ala Ser Glu Ala Pro 
785                 790                 795                 800 


Thr Met Gln Glu Val Pro Arg Pro Met Ala Ile Gln Pro Asn Ser Pro 
                805                 810                 815     


Glu Gln Pro Pro Ser Ala Arg Leu Gln Pro Gln 
            820                 825         


<210>  11
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr 
            900                 905                 910         


His Leu Ser Trp Ile Gln Asn Ile Leu 
        915                 920     


