                         SEQUENCE LISTING

<110>  MEDGENICS MEDICAL ISRAEL LTD.
       NEIL, Garry
       SHAPIR, Nir
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM 
       DISEASES

<130>  01118-0025-00PCT

<150>  US 62/277,365
<151>  2016-01-11

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  744
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized light chain sequence from adalimumab contained in TNF1 
       construct

<400>  1
gacatccaaa tgacacagag tccttcctcc ttgtcagcta gtgttggaga ccgcgttact       60

atcacatgca gggcgtcaca aggcatcagg aattacttgg cgtggtacca gcagaagcct      120

ggaaaagccc caaaactgct gatatacgca gccagcacac ttcaatcagg cgtgccctct      180

aggttctctg gctccggttc cggaaccgac ttcacactca ccatatcctc actgcaacct      240

gaagacgtgg ccacatacta ttgtcagcgc tataataggg caccctacac ttttggccaa      300

gggacgaaag tggaaataaa aaggacagtg gcagctccgt ccgtttttat cttccctcca      360

tccgatgagc agcttaagtc tgggactgct tccgtagtgt gtttgctgaa taatttttat      420

ccccgagaag caaaggttca gtggaaggtc gataatgccc tgcagagtgg caatagtcag      480

gagtccgtaa ccgagcagga ctctaaggac tccacctatt ccctgagttc caccttgacc      540

ctttccaagg ccgactatga gaagcacaaa gtatacgcct gcgaggtaac tcaccaggga      600

ttgagctccc cagtgacaaa gtcatttaat cggggcgagt gcctgtccaa ggccgactac      660

gaaaagcaca aagtgtacgc ctgtgaagtc acccatcagg gcctgtcatc tccagtcacg      720

aagtcattca atcgagggga gtgc                                             744


<210>  2
<211>  744
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized light chain sequence from adalimumab contained in TNF3 
       construct

<400>  2
gacatccaga tgacgcagtc cccaagctca ctgtccgcct ctgtaggtga ccgggtaact       60

atcacctgca gagcatccca gggcatccgc aattacctgg cctggtatca gcagaaacct      120

ggcaaggccc caaaactcct catctacgca gcatccaccc ttcagagtgg cgtaccaagc      180

cgattctccg gaagcggtag tggaaccgac tttaccctca caatctcaag tctgcagcct      240

gaagatgtcg ctacatatta ttgccagaga tacaataggg ccccatacac ctttgggcag      300

ggcacgaaag tggaaattaa gcgcacagtt gcggcaccaa gtgtgtttat tttcccgccc      360

agcgatgaac agctgaaatc cggcacggcc agcgttgtat gcttgctgaa taacttttac      420

cctagagagg ccaaggtcca atggaaggtt gacaacgcac tgcagtccgg caacagtcaa      480

gagagcgtca ctgaacaaga ttccaaggac agtacatact cactcagctc cacactgaca      540

ctctccaagg ccgactacga gaagcataag gtctacgctt gcgaggtaac gcatcagggc      600

ctttctagcc cagttaccaa aagtttcaat cgaggcgaat gcctgtcaaa agcagactac      660

gagaaacaca aggtttacgc ctgtgaagtg acacaccagg gcttgagctc ccctgtgaca      720

aaatctttta ataggggaga gtgt                                             744


<210>  3
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized heavy chain sequence from adalimumab contained in TNF1 
       construct

<400>  3
gaagtgcagc ttgtggagtc tggcggtggc ctcgtgcagc caggccggag cctgcggctg       60

agctgtgcag ccagcgggtt caccttcgat gattatgcta tgcactgggt tcgccaggcc      120

cccggaaagg gcctggagtg ggtctcagct atcacatgga attccggaca catcgactac      180

gccgacagcg tggaggggcg ctttaccatt tcaagggaca acgctaaaaa cagcctgtac      240

cttcagatga actccctgcg ggcggaagac acagcggtgt actactgtgc caaggtgagc      300

tacctgtcca cagcatcctc attggactat tggggccaag gcacgctggt taccgtttcc      360

agcgcaagca caaagggacc tagtgtgttc ccgttggccc cttcaagcaa atccacgagt      420

ggaggcaccg ctgcactggg ctgccttgta aaggactact tcccggagcc agtgactgtg      480

tcatggaaca gtggcgccct gacaagcgga gtccacactt ttcctgcggt cctccagtcc      540

tccgggcttt acagcctgag tagtgtggtt accgtcccct catcctccct gggtacccag      600

acctacattt gtaatgtgaa ccataagcca agcaatacaa aggtggataa aaaggtggag      660

ccaaaaagct gcgataaaac acatacttgc cctccttgcc cagcgcccga gttgctcggc      720

ggcccttccg tatttctttt tccaccgaaa ccgaaggata cactgatgat ctctcggacc      780

cctgaggtca cttgtgtggt ggttgacgtt tcacacgagg acccagaagt gaagtttaat      840

tggtacgtgg atggggttga ggtgcacaat gctaaaacca agccgcgcga ggagcaatat      900

aactctacct atcgagtggt gagcgtgctc accgtactcc atcaggactg gctgaacggg      960

aaggagtaca agtgcaaggt ttcaaacaag gctctccctg ccccaataga gaagaccata     1020

agtaaagcca agggacagcc tcgcgagcca caggtctata ctctgcctcc tagtagggac     1080

gagctcacca agaaccaggt aagcctcacc tgcttggtca agggctttta tccatccgac     1140

atcgccgtgg aatgggagag caacggacag cctgaaaaca actacaaaac taccccaccc     1200

gttcttgatt cagatgggag cttttttctg tacagcaagt tgaccgtcga taaatcccga     1260

tggcagcagg gaaatgtttt ctcttgctca gtgatgcatg aagcgctgca caaccactat     1320

acacagaaga gccttagctt gtctccagga aaa                                  1353


<210>  4
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized heavy chain sequence from adalimumab contained in TNF3 
       construct

<400>  4
gaagtgcagt tggtcgagtc cggtggaggg ctggtccagc ctggcagaag tctccggctg       60

agttgcgcag ccagcggatt caccttcgac gattacgcca tgcactgggt gcggcaggcc      120

ccgggcaagg gccttgaatg ggtgtctgcg atcacatgga attccggaca tattgattac      180

gccgacagcg tggagggccg attcaccatc agtagggata atgctaagaa ctccctgtac      240

ctgcagatga atagtctgag ggctgaagac acagccgtgt actattgcgc aaaagtcagc      300

tacctctcca ctgcttctag tctggactac tggggtcagg ggacgctggt gacggtttct      360

tccgcatcca ctaaaggtcc tagcgttttc cccctcgccc cctcttctaa gagcacctcc      420

ggaggaactg cagcccttgg atgcttggtt aaagattact ttcccgaacc cgtaaccgta      480

agctggaaca gtggcgccct gacttcaggg gtacacacct ttccggccgt gctgcagagc      540

agcgggctct atagccttag ctcagtcgtg acggtcccat cctctagtct tggtactcaa      600

acctacatct gcaatgtgaa tcacaagcct tctaacacaa aagttgataa gaaagtagaa      660

cccaagagct gtgataagac acatacttgt cctccctgtc cggcccccga attgcttggg      720

gggccgagtg tcttcctctt ccctccaaaa cccaaggaca ctctcatgat ttcaaggacc      780

cctgaagtga cttgtgtggt agttgacgtg agccacgagg accctgaagt gaagttcaat      840

tggtatgtgg atggcgttga ggtgcataat gcaaagacaa agccacgcga ggagcagtac      900

aattccacct atagggtggt atccgtgctg accgtgttgc atcaggactg gctcaatggg      960

aaagagtata aatgtaaggt gtccaataag gccctgcccg ctcccattga aaaaacaatt     1020

tcaaaggcta agggccaacc ccgcgaacca caagtctaca cactcccccc tagtagagat     1080

gagctgacaa aaaatcaggt gtctctcaca tgtctggtaa aaggcttcta tccttcagat     1140

attgctgtgg aatgggaatc aaatgggcag ccagagaata actacaaaac gacaccccca     1200

gtccttgata gtgacgggtc cttcttcctc tactctaaac tcaccgtgga caagagtaga     1260

tggcaacagg gcaatgtgtt ctcctgtagc gtcatgcatg aagcactgca caatcattat     1320

actcagaaga gcttgtccct tagtccagga aaa                                  1353


<210>  5
<211>  136
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain signal sequence containing intron

<400>  5
ggatggagct gtatcatcct cttcttggta gcaacagcta caggtaaggg gttaacagta       60

gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg cctttctctc      120

cacaggcgcg cactcc                                                      136


<210>  6
<211>  423
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV enhancer

<400>  6
gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg       60

ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc      120

caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg      180

ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt      240

ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt      300

ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt      360

caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg      420

gtg                                                                    423


<210>  7
<211>  224
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1-alpha promoter

<400>  7
actagtggag aagagcatgc ttgagggctg agtgcccctc agtgggcaga gagcacatgg       60

cccacagtcc ctgagaagtt ggggggaggg gtgggcaatt gaactggtgc ctagagaagg      120

tggggcttgg gtaaactggg aaagtgatgt ggtgtactgg ctccaccttt ttccccaggg      180

tgggggagaa ccatatataa gtgcagtagt ctctgtgaac attc                       224


<210>  8
<211>  427
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG-free MAR from human beta-globin gene

<400>  8
ttaattaaaa ttatctctaa ggcatgtgaa ctggctgtct tggttttcat ctgtacttca       60

tctgctacct ctgtgacctg aaacatattt ataattccat taagctgtgc atatgataga      120

tttatcatat gtattttcct taaaggattt ttgtaagaac taattgaatt gatacctgta      180

aagtctttat cacactaccc aataaataat aaatctcttt gttcagctct ctgtttctat      240

aaatatgtac cagttttatt gtttttagtg gtagtgattt tattctcttt ctatatatat      300

acacacacat gtgtgcattc ataaatatat acaattttta tgaataaaaa attattagca      360

atcaatattg aaaaccactg atttttgttt atgtgagcaa acagcagatt aaaaggctag      420

cctgcag                                                                427


<210>  9
<211>  808
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAR 5' region from human IFN-beta gene

<400>  9
agtcaatatg ttcaccccaa aaaagctgtt tgttaacttg ccaacctcat tctaaaatgt       60

atatagaagc ccaaaagaca ataacaaaaa tattcttgta gaacaaaatg ggaaagaatg      120

ttccactaaa tatcaagatt tagagcaaag catgagatgt gtggggatag acagtgaggc      180

tgataaaata gagtagagct cagaaacaga cccattgata tatgtaagtg acctatgaaa      240

aaaatatggc attttacaat gggaaaatga tggtcttttt cttttttaga aaaacaggga      300

aatatattta tatgtaaaaa ataaaaggga acccatatgt cataccatac acacaaaaaa      360

attccagtga attataagtc taaatggaga aggcaaaact ttaaatcttt tagaaaataa      420

tatagaagca tgccatcaag acttcagtgt agagaaaaat ttcttatgac tcaaagtcct      480

aaccacaaag aaaagattgt taattagatt gcatgaatat taagacttat ttttaaaatt      540

aaaaaaccat taagaaaagt caggccatag aatgacagaa aatatttgca acaccccagt      600

aaagagaatt gtaatatgca gattataaaa agaagtctta caaatcagta aaaaataaaa      660

ctagacaaaa atttgaacag atgaaagaga aactctaaat aatcattaca catgagaaac      720

tcaatctcag aaatcagaga actatcattg catatacact aaattagaga aatattaaaa      780

ggctaagtaa catctgtggc ttaattaa                                         808


<210>  10
<211>  231
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 polyadenylation signal

<400>  10
ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa       60

aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc      120

aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg      180

tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt c               231


<210>  11
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Furin sequence

<400>  11
cgggcaaaac gg                                                           12


<210>  12
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  2A sequence

<400>  12
gctcccgtta aacagacgct gaatttcgat ctcctgaagt tggccggaga cgtcgaatca       60

aaccccggcc ca                                                           72


<210>  13
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IRES sequence

<400>  13
atgataatat ggccacaacc atg                                               23


<210>  14
<211>  2540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of the TNF1 construct

<400>  14
gttggtgtac agtagtagca agcttgcatg cctgcaggtc gactctagac tgccatggga       60

tggagctgta tcatcctctt cttggtagca acagctacag gtaaggggtt aacagtagca      120

ggcttgaggt ctggacatat atatgggtga caatgacatc cactttgcct ttctctccac      180

aggcgcgcac tccgacatcc aaatgacaca gagtccttcc tccttgtcag ctagtgttgg      240

agaccgcgtt acttcacatg cagggcgtca caaggcatca ggaattactt ggcgtggtac      300

cagcagaagc ctggaaaagc cccaaaactg ctgatatacg cagccagcac acttcaatca      360

ggcgtgccct ctaggttctc tggctccggt tccggaaccg acttcacact caccatatcc      420

tcactgcaac ctgaagacgt ggccacatac tattgtcagc gctataatag ggcaccctac      480

acttttggcc aagggacgaa agtggaaata aaaaggacag tggcagctcc gtccgttttt      540

atcttccctc catccgatga gcagcttaag tctgggactg cttccgtagt gtgtttgctg      600

aataattttt atccccgaga agcaaaggtt cagtggaagg tcgataatgc cctgcagagt      660

ggcaatagtc aggagtccgt aaccgagcag gactctaagg actccaccta ttccctgagt      720

tccaccttga ccctttccaa ggccgactat gagaagcaca aagtatacgc ctgcgaggta      780

actcaccagg gattgagctc cccagtgaca aagtcattta atcggggcga gtgcctgtcc      840

aaggccgact acgaaaagca caaagtgtac gcctgtgaag tcacccatca gggcctgtca      900

tctccagtca cgaagtcatt caatcgaggg gagtgccggg caaaacgggc tcccgttaaa      960

cagacgctga atttcgatct cctgaagttg gccggagacg tcgaatcaaa ccccggccca     1020

ggatggagct gtatcatcct cttcttggta gcaacagcta caggtaaggg gttaacagta     1080

gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg cctttctctc     1140

cacaggcgcg cactccgaag tgcagcttgt ggagtctggc ggtggcctcg tgcagccagg     1200

ccggagcctg cggctgagct gtgcagccag cgggttcacc ttcgatgatt atgctatgca     1260

ctgggttcgc caggcccccg gaaagggcct ggagtgggtc tcagctatca catggaattc     1320

cggacacatc gactacgccg acagcgtgga ggggcgcttt accatttcaa gggacaacgc     1380

taaaaacagc ctgtaccttc agatgaactc cctgcgggcg gaagacacag cggtgtacta     1440

ctgtgccaag gtgagctacc tgtccacagc atcctcattg gactattggg gccaaggcac     1500

gctggttacc gtttccagcg caagcacaaa gggacctagt gtgttcccgt tggccccttc     1560

aagcaaatcc acgagtggag gcaccgctgc actgggctgc cttgtaaagg actacttccc     1620

ggagccagtg actgtgtcat ggaacagtgg cgccctgaca agcggagtcc acacttttcc     1680

tgcggtcctc cagtcctccg ggctttacag cctgagtagt gtggttaccg tcccctcatc     1740

ctccctgggt acccagacct acatttgtaa tgtgaaccat aagccaagca atacaaaggt     1800

ggataaaaag gtggagccaa aaagctgcga taaaacacat acttgccctc cttgcccagc     1860

gcccgagttg ctcggcggcc cttccgtatt tctttttcca ccgaaaccga aggatacact     1920

gatgatctct cggacccctg aggtcacttg tgtggtggtt gacgtttcac acgaggaccc     1980

agaagtgaag tttaattggt acgtggatgg ggttgaggtg cacaatgcta aaaccaagcc     2040

gcgcgaggag caatataact ctacctatcg agtggtgagc gtgctcaccg tactccatca     2100

ggactggctg aacgggaagg agtacaagtg caaggtttca aacaaggctc tccctgcccc     2160

aatagagaag accataagta aagccaaggg acagcctcgc gagccacagg tctatactct     2220

gcctcctagt agggacgagc tcaccaagaa ccaggtaagc ctcacctgct tggtcaaggg     2280

cttttatcca tccgacatcg ccgtggaatg ggagagcaac ggacagcctg aaaacaacta     2340

caaaactacc ccacccgttc ttgattcaga tgggagcttt tttctgtaca gcaagttgac     2400

cgtcgataaa tcccgatggc agcagggaaa tgttttctct tgctcagtga tgcatgaagc     2460

gctgcacaac cactatacac agaagagcct tagcttgtct ccaggaaaat gaggatcccc     2520

gggagatatc ctaggcttgg                                                 2540


<210>  15
<211>  2486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of the TNF3 construct

<400>  15
gttggtgtac agtagtagca agcttgcatg cctgcaggtc gactctagac tgccatggga       60

tggagctgta tcatcctctt cttggtagca acagctacag gtaaggggtt aacagtagca      120

ggcttgaggt ctggacatat atatgggtga caatgacatc cactttgcct ttctctccac      180

aggcgcgcac tccgacatcc agatgacgca gtccccaagc tcactgtccg cctctgtagg      240

tgaccgggta actatcacct gcagagcatc ccagggcatc cgcaattacc tggcctggta      300

tcagcagaaa cctggcaagg ccccaaaact cctcatctac gcagcatcca cccttcagag      360

tggcgtacca agccgattct ccggaagcgg tagtggaacc gactttaccc tcacaatctc      420

aagtctgcag cctgaagatg tcgctacata ttattgccag agatacaata gggccccata      480

cacctttggg cagggcacga aagtggaaat taagcgcaca gttgcggcac caagtgtgtt      540

tattttcccg cccagcgatg aacagctgaa atccggcacg gccagcgttg tatgcttgct      600

gaataacttt taccctagag aggccaaggt ccaatggaag gttgacaacg cactgcagtc      660

cggcaacagt caagagagcg tcactgaaca agattccaag gacagtacat actcactcag      720

ctccacactg acactctcca aggccgacta cgagaagcat aaggtctacg cttgcgaggt      780

aacgcatcag ggcctttcta gcccagttac caaaagtttc aatcgaggcg aatgcctgtc      840

aaaagcagac tacgagaaac acaaggttta cgcctgtgaa gtgacacacc agggcttgag      900

ctcccctgtg acaaaatctt ttaatagggg agagtgttga atgataatat ggccacaacc      960

atgatgggat ggagctgtat catcctcttc ttggtagcaa cagctacagg taaggggtta     1020

acagtagcag gcttgaggtc tggacatata tatgggtgac aatgacatcc actttgcctt     1080

tctctccaca ggcgcgcact ccgaagtgca gttggtcgag tccggtggag ggctggtcca     1140

gcctggcaga agtctccggc tgagttgcgc agccagcgga ttcaccttcg acgattacgc     1200

catgcactgg gtgcggcagg ccccgggcaa gggccttgaa tgggtgtctg cgatcacatg     1260

gaattccgga catattgatt acgccgacag cgtggagggc cgattcacca tcagtaggga     1320

taatgctaag aactccctgt acctgcagat gaatagtctg agggctgaag acacagccgt     1380

gtactattgc gcaaaagtca gctacctctc cactgcttct agtctggact actggggtca     1440

ggggacgctg gtgacggttt cttccgcatc cactaaaggt cctagcgttt tccccctcgc     1500

cccctcttct aagagcacct ccggaggaac tgcagccctt ggatgcttgg ttaaagatta     1560

ctttcccgaa cccgtaaccg taagctggaa cagtggcgcc ctgacttcag gggtacacac     1620

ctttccggcc gtgctgcaga gcagcgggct ctatagcctt agctcagtcg tgacggtccc     1680

atcctctagt cttggtactc aaacctacat ctgcaatgtg aatcacaagc cttctaacac     1740

aaaagttgat aagaaagtag aacccaagag ctgtgataag acacatactt gtcctccctg     1800

tccggccccc gaattgcttg gggggccgag tgtcttcctc ttccctccaa aacccaagga     1860

cactctcatg atttcaagga cccctgaagt gacttgtgtg gtagttgacg tgagccacga     1920

ggaccctgaa gtgaagttca attggtatgt ggatggcgtt gaggtgcata atgcaaagac     1980

aaagccacgc gaggagcagt acaattccac ctatagggtg gtatccgtgc tgaccgtgtt     2040

gcatcaggac tggctcaatg ggaaagagta taaatgtaag gtgtccaata aggccctgcc     2100

cgctcccatt gaaaaaacaa tttcaaaggc taagggccaa ccccgcgaac cacaagtcta     2160

cacactcccc cctagtagag atgagctgac aaaaaatcag gtgtctctca catgtctggt     2220

aaaaggcttc tatccttcag atattgctgt ggaatgggaa tcaaatgggc agccagagaa     2280

taactacaaa acgacacccc cagtccttga tagtgacggg tccttcttcc tctactctaa     2340

actcaccgtg gacaagagta gatggcaaca gggcaatgtg ttctcctgta gcgtcatgca     2400

tgaagcactg cacaatcatt atactcagaa gagcttgtcc cttagtccag gaaaatgagg     2460

atccccggga gatatcctag gcttgg                                          2486


<210>  16
<211>  8101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of pAd-MAR-EF1a-opt hTNF1

<400>  16
ggccgattca ttaatgcagg ggccgctgcg gccatcatca ataatatacc ttattttgga       60

ttgaagccaa tatgataatg agggggtgga gtttgtgacg tggcgcgggg cgtgggaacg      120

gggcgggtga cgtagtagtg tggcggaagt gtgatgttgc aagtgtggcg gaacacatgt      180

aagcgacgga tgtggcaaaa gtgacgtttt tggtgtgcgc cggtgtacac aggaagtgac      240

aattttcgcg cggttttagg cggatgttgt agtaaatttg ggcgtaaccg agtaagattt      300

ggccattttc gcgggaaaac tgaataagag gaagtgaaat ctgaataatt ttgtgttact      360

catagcgcgt aatatttgtc tagggccgcg gggactttga ccgtttacgt ggagactcgc      420

ccaggtgttt ttctcaggtg ttttccgcgt tccgggtcaa agttggcgtt ttattattat      480

agtcagctga cgtgtagtgt atttataccc ggtgagttcc tcaagaggcc actcttgagt      540

gccagcgagt agagttttct cctccgagcc gctccgacac cgggaggcgc gccttaatta      600

aaattatctc taaggcatgt gaactggctg tcttggtttt catctgtact tcatctgcta      660

cctctgtgac ctgaaacata tttataattc cattaagctg tgcatatgat agatttatca      720

tatgtatttt ccttaaagga tttttgtaag aactaattga attgatacct gtaaagtctt      780

tatcacacta cccaataaat aataaatctc tttgttcagc tctctgtttc tataaatatg      840

taccagtttt attgttttta gtggtagtga ttttattctc tttctatata tatacacaca      900

catgtgtgca ttcataaata tatacaattt ttatgaataa aaaattatta gcaatcaata      960

ttgaaaacca ctgatttttg tttatgtgag caaacagcag attaaaaggc tagcctgcag     1020

gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg     1080

ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc     1140

caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg     1200

ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt     1260

ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt     1320

ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt     1380

caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg     1440

gtgactagtg gagaagagca tgcttgaggg ctgagtgccc ctcagtgggc agagagcaca     1500

tggcccacag tccctgagaa gttgggggga ggggtgggca attgaactgg tgcctagaga     1560

aggtggggct tgggtaaact gggaaagtga tgtggtgtac tggctccacc tttttcccca     1620

gggtggggga gaaccatata taagtgcagt agtctctgtg aacattcaag catctgcctt     1680

ctccctcctg tgagtttggt aagtcactga ctgtctatgc ctgggaaagg gtgggcagga     1740

ggtggggcag tgcaggaaaa gtggcactgt gaaccctgca gccctagaca attgtactaa     1800

ccttcttctc tttcctctcc tgacaggttg gtgtacagta gtagcaagct tgcatgcctg     1860

caggtcgact ctagactgcc atgggatgga gctgtatcat cctcttcttg gtagcaacag     1920

ctacaggtaa ggggttaaca gtagcaggct tgaggtctgg acatatatat gggtgacaat     1980

gacatccact ttgcctttct ctccacaggc gcgcactccg acatccaaat gacacagagt     2040

ccttcctcct tgtcagctag tgttggagac cgcgttacta tcacatgcag ggcgtcacaa     2100

ggcatcagga attacttggc gtggtaccag cagaagcctg gaaaagcccc aaaactgctg     2160

atatacgcag ccagcacact tcaatcaggc gtgccctcta ggttctctgg ctccggttcc     2220

ggaaccgact tcacactcac catatcctca ctgcaacctg aagacgtggc cacatactat     2280

tgtcagcgct ataatagggc accctacact tttggccaag ggacgaaagt ggaaataaaa     2340

aggacagtgg cagctccgtc cgtttttatc ttccctccat ccgatgagca gcttaagtct     2400

gggactgctt ccgtagtgtg tttgctgaat aatttttatc cccgagaagc aaaggttcag     2460

tggaaggtcg ataatgccct gcagagtggc aatagtcagg agtccgtaac cgagcaggac     2520

tctaaggact ccacctattc cctgagttcc accttgaccc tttccaaggc cgactatgag     2580

aagcacaaag tatacgcctg cgaggtaact caccagggat tgagctcccc agtgacaaag     2640

tcatttaatc ggggcgagtg cctgtccaag gccgactacg aaaagcacaa agtgtacgcc     2700

tgtgaagtca cccatcaggg cctgtcatct ccagtcacga agtcattcaa tcgaggggag     2760

tgccgggcaa aacgggctcc cgttaaacag acgctgaatt tcgatctcct gaagttggcc     2820

ggagacgtcg aatcaaaccc cggcccagga tggagctgta tcatcctctt cttggtagca     2880

acagctacag gtaaggggtt aacagtagca ggcttgaggt ctggacatat atatgggtga     2940

caatgacatc cactttgcct ttctctccac aggcgcgcac tccgaagtgc agcttgtgga     3000

gtctggcggt ggcctcgtgc agccaggccg gagcctgcgg ctgagctgtg cagccagcgg     3060

gttcaccttc gatgattatg ctatgcactg ggttcgccag gcccccggaa agggcctgga     3120

gtgggtctca gctatcacat ggaattccgg acacatcgac tacgccgaca gcgtggaggg     3180

gcgctttacc atttcaaggg acaacgctaa aaacagcctg taccttcaga tgaactccct     3240

gcgggcggaa gacacagcgg tgtactactg tgccaaggtg agctacctgt ccacagcatc     3300

ctcattggac tattggggcc aaggcacgct ggttaccgtt tccagcgcaa gcacaaaggg     3360

acctagtgtg ttcccgttgg ccccttcaag caaatccacg agtggaggca ccgctgcact     3420

gggctgcctt gtaaaggact acttcccgga gccagtgact gtgtcatgga acagtggcgc     3480

cctgacaagc ggagtccaca cttttcctgc ggtcctccag tcctccgggc tttacagcct     3540

gagtagtgtg gttaccgtcc cctcatcctc cctgggtacc cagacctaca tttgtaatgt     3600

gaaccataag ccaagcaata caaaggtgga taaaaaggtg gagccaaaaa gctgcgataa     3660

aacacatact tgccctcctt gcccagcgcc cgagttgctc ggcggccctt ccgtatttct     3720

ttttccaccg aaaccgaagg atacactgat gatctctcgg acccctgagg tcacttgtgt     3780

ggtggttgac gtttcacacg aggacccaga agtgaagttt aattggtacg tggatggggt     3840

tgaggtgcac aatgctaaaa ccaagccgcg cgaggagcaa tataactcta cctatcgagt     3900

ggtgagcgtg ctcaccgtac tccatcagga ctggctgaac gggaaggagt acaagtgcaa     3960

ggtttcaaac aaggctctcc ctgccccaat agagaagacc ataagtaaag ccaagggaca     4020

gcctcgcgag ccacaggtct atactctgcc tcctagtagg gacgagctca ccaagaacca     4080

ggtaagcctc acctgcttgg tcaagggctt ttatccatcc gacatcgccg tggaatggga     4140

gagcaacgga cagcctgaaa acaactacaa aactacccca cccgttcttg attcagatgg     4200

gagctttttt ctgtacagca agttgaccgt cgataaatcc cgatggcagc agggaaatgt     4260

tttctcttgc tcagtgatgc atgaagcgct gcacaaccac tatacacaga agagccttag     4320

cttgtctcca ggaaaatgag gatccccggg agatatccta ggcttggcca gacatgataa     4380

gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt     4440

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta     4500

acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt     4560

aaagcaagta aaacctctac aaatgtggta tggaattcag tcaatatgtt caccccaaaa     4620

aagctgtttg ttaacttgcc aacctcattc taaaatgtat atagaagccc aaaagacaat     4680

aacaaaaata ttcttgtaga acaaaatggg aaagaatgtt ccactaaata tcaagattta     4740

gagcaaagca tgagatgtgt ggggatagac agtgaggctg ataaaataga gtagagctca     4800

gaaacagacc cattgatata tgtaagtgac ctatgaaaaa aatatggcat tttacaatgg     4860

gaaaatgatg gtctttttct tttttagaaa aacagggaaa tatatttata tgtaaaaaat     4920

aaaagggaac ccatatgtca taccatacac acaaaaaaat tccagtgaat tataagtcta     4980

aatggagaag gcaaaacttt aaatctttta gaaaataata tagaagcatg ccatcaagac     5040

ttcagtgtag agaaaaattt cttatgactc aaagtcctaa ccacaaagaa aagattgtta     5100

attagattgc atgaatatta agacttattt ttaaaattaa aaaaccatta agaaaagtca     5160

ggccatagaa tgacagaaaa tatttgcaac accccagtaa agagaattgt aatatgcaga     5220

ttataaaaag aagtcttaca aatcagtaaa aaataaaact agacaaaaat ttgaacagat     5280

gaaagagaaa ctctaaataa tcattacaca tgagaaactc aatctcagaa atcagagaac     5340

tatcattgca tatacactaa attagagaaa tattaaaagg ctaagtaaca tctgtggctt     5400

aattaaggcg cgccgggccc ctacgtcacc cgccccgttc ccacgccccg cgccacgtca     5460

caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat attattgatg     5520

atggccgcag cggccctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca     5580

gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg     5640

tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt     5700

cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg     5760

ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga     5820

ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac     5880

gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc     5940

tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa     6000

aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgcttacaat     6060

ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     6120

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     6180

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     6240

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     6300

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     6360

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     6420

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     6480

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     6540

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     6600

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     6660

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     6720

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     6780

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     6840

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     6900

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     6960

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     7020

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     7080

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     7140

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7200

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7260

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7320

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg     7380

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7440

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7500

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     7560

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     7620

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     7680

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     7740

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     7800

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     7860

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     7920

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     7980

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     8040

taatgcaggg gccgctgcgg ccatcatcaa taatatacct tattttggat tgaagccaat     8100

a                                                                     8101


<210>  17
<211>  8042
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of pAd-MAR-EF1a-opt hTNF3

<400>  17
ggccgattca ttaatgcagg ggccgctgcg gccatcatca ataatatacc ttattttgga       60

ttgaagccaa tatgataatg agggggtgga gtttgtgacg tggcgcgggg cgtgggaacg      120

gggcgggtga cgtagtagtg tggcggaagt gtgatgttgc aagtgtggcg gaacacatgt      180

aagcgacgga tgtggcaaaa gtgacgtttt tggtgtgcgc cggtgtacac aggaagtgac      240

aattttcgcg cggttttagg cggatgttgt agtaaatttg ggcgtaaccg agtaagattt      300

ggccattttc gcgggaaaac tgaataagag gaagtgaaat ctgaataatt ttgtgttact      360

catagcgcgt aatatttgtc tagggccgcg gggactttga ccgtttacgt ggagactcgc      420

ccaggtgttt ttctcaggtg ttttccgcgt tccgggtcaa agttggcgtt ttattattat      480

agtcagctga cgtgtagtgt atttataccc ggtgagttcc tcaagaggcc actcttgagt      540

gccagcgagt agagttttct cctccgagcc gctccgacac cgggaggcgc gccttaatta      600

aaattatctc taaggcatgt gaactggctg tcttggtttt catctgtact tcatctgcta      660

cctctgtgac ctgaaacata tttataattc cattaagctg tgcatatgat agatttatca      720

tatgtatttt ccttaaagga tttttgtaag aactaattga attgatacct gtaaagtctt      780

tatcacacta cccaataaat aataaatctc tttgttcagc tctctgtttc tataaatatg      840

taccagtttt attgttttta gtggtagtga ttttattctc tttctatata tatacacaca      900

catgtgtgca ttcataaata tatacaattt ttatgaataa aaaattatta gcaatcaata      960

ttgaaaacca ctgatttttg tttatgtgag caaacagcag attaaaaggc tagcctgcag     1020

gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg     1080

ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc     1140

caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg     1200

ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt     1260

ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt     1320

ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt     1380

caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg     1440

gtgactagtg gagaagagca tgcttgaggg ctgagtgccc ctcagtgggc agagagcaca     1500

tggcccacag tccctgagaa gttgggggga ggggtgggca attgaactgg tgcctagaga     1560

aggtggggct tgggtaaact gggaaagtga tgtggtgtac tggctccacc tttttcccca     1620

gggtggggga gaaccatata taagtgcagt agtctctgtg aacattcaag catctgcctt     1680

ctccctcctg tgagtttggt aagtcactga ctgtctatgc ctgggaaagg gtgggcagga     1740

ggtggggcag tgcaggaaaa gtggcactgt gaaccctgca gccctagaca attgtactaa     1800

ccttcttctc tttcctctcc tgacaggttg gtgtacagta gtagcaagct tgcatgcctg     1860

caggtcgact ctagactgcc atgggatgga gctgtatcat cctcttcttg gtagcaacag     1920

ctacaggtaa ggggttaaca gtagcaggct tgaggtctgg acatatatat gggtgacaat     1980

gacatccact ttgcctttct ctccacaggc gcgcactccg acatccagat gacgcagtcc     2040

ccaagctcac tgtccgcctc tgtaggtgac cgggtaacta tcacctgcag agcatcccag     2100

ggcatccgca attacctggc ctggtatcag cagaaacctg gcaaggcccc aaaactcctc     2160

atctacgcag catccaccct tcagagtggc gtaccaagcc gattctccgg aagcggtagt     2220

ggaaccgact ttaccctcac aatctcaagt ctgcagcctg aagatgtcgc tacatattat     2280

tgccagagat acaatagggc cccatacacc tttgggcagg gcacgaaagt ggaaattaag     2340

cgcacagttg cggcaccaag tgtgtttatt ttcccgccca gcgatgaaca gctgaaatcc     2400

cggccagcgt tgtatgcttg ctgaataact tttaccctag agaggccaag gtccaatgga     2460

aggttgacaa cgcactgcag tccggcaaca gtcaagagag cgtcactgaa caagattcca     2520

aggacagtac atactcactc agctccacac tgacactctc caaggccgac tacgagaagc     2580

ataaggtcta cgcttgcgag gtaacgcatc agggcctttc tagcccagtt accaaaagtt     2640

tcaatcgagg cgaatgcctg tcaaaagcag actacgagaa acacaaggtt tacgcctgtg     2700

aagtgacaca ccagggcttg agctcccctg tgacaaaatc ttttaatagg ggagagtgtt     2760

gaatgataat atggccacaa ccatgatggg atggagctgt atcatcctct tcttggtagc     2820

aacagctaca ggtaaggggt taacagtagc aggcttgagg tctggacata tatatgggtg     2880

acaatgacat ccactttgcc tttctctcca caggcgcgca ctccgaagtg cagttggtcg     2940

agtccggtgg agggctggtc cagcctggca gaagtctccg gctgagttgc gcagccagcg     3000

gattcacctt cgacgattac gccatgcact gggtgcggca ggccccgggc aagggccttg     3060

aatgggtgtc tgcgatcaca tggaattccg gacatattga ttacgccgac agcgtggagg     3120

gccgattcac catcagtagg gataatgcta agaactccct gtacctgcag atgaatagtc     3180

tgagggctga agacacagcc gtgtactatt gcgcaaaagt cagctacctc tccactgctt     3240

ctagtctgga ctactggggt caggggacgc tggtgacggt ttcttccgca tccactaaag     3300

gtcctagcgt tttccccctc gccccctctt ctaagagcac ctccggagga actgcagccc     3360

ttggatgctt ggttaaagat tactttcccg aacccgtaac cgtaagctgg aacagtggcg     3420

ccctgacttc aggggtacac acctttccgg ccgtgctgca gagcagcggg ctctatagcc     3480

ttagctcagt cgtgacggtc ccatcctcta gtcttggtac tcaaacctac atctgcaatg     3540

tgaatcacaa gccttctaac acaaaagttg ataagaaagt agaacccaag agctgtgata     3600

agacacatac ttgtcctccc tgtccggccc ccgaattgct tggggggccg agtgtcttcc     3660

tcttccctcc aaaacccaag gacactctca tgatttcaag gacccctgaa gtgacttgtg     3720

tggtagttga cgtgagccac gaggaccctg aagtgaagtt caattggtat gtggatggcg     3780

ttgaggtgca taatgcaaag acaaagccac gcgaggagca gtacaattcc acctataggg     3840

tggtatccgt gctgaccgtg ttgcatcagg actggctcaa tgggaaagag tataaatgta     3900

aggtgtccaa taaggccctg cccgctccca ttgaaaaaac aatttcaaag gctaagggcc     3960

aaccccgcga accacaagtc tacacactcc cccctagtag agatgagctg acaaaaaatc     4020

aggtgtctct cacatgtctg gtaaaaggct tctatccttc agatattgct gtggaatggg     4080

aatcaaatgg gcagccagag aataactaca aaacgacacc cccagtcctt gatagtgacg     4140

ggtccttctt cctctactct aaactcaccg tggacaagag tagatggcaa cagggcaatg     4200

tgttctcctg tagcgtcatg catgaagcac tgcacaatca ttatactcag aagagcttgt     4260

cccttagtcc aggaaaatga ggatccccgg gagatatcct aggcttggcc agacatgata     4320

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     4380

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     4440

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     4500

taaagcaagt aaaacctcta caaatgtggt atggaattca gtcaatatgt tcaccccaaa     4560

aaagctgttt gttaacttgc caacctcatt ctaaaatgta tatagaagcc caaaagacaa     4620

taacaaaaat attcttgtag aacaaaatgg gaaagaatgt tccactaaat atcaagattt     4680

agagcaaagc atgagatgtg tggggataga cagtgaggct gataaaatag agtagagctc     4740

agaaacagac ccattgatat atgtaagtga cctatgaaaa aaatatggca ttttacaatg     4800

ggaaaatgat ggtctttttc ttttttagaa aaacagggaa atatatttat atgtaaaaaa     4860

taaaagggaa cccatatgtc ataccataca cacaaaaaaa ttccagtgaa ttataagtct     4920

aaatggagaa ggcaaaactt taaatctttt agaaaataat atagaagcat gccatcaaga     4980

cttcagtgta gagaaaaatt tcttatgact caaagtccta accacaaaga aaagattgtt     5040

aattagattg catgaatatt aagacttatt tttaaaatta aaaaaccatt aagaaaagtc     5100

aggccataga atgacagaaa atatttgcaa caccccagta aagagaattg taatatgcag     5160

attataaaaa gaagtcttac aaatcagtaa aaaataaaac tagacaaaaa tttgaacaga     5220

tgaaagagaa actctaaata atcattacac atgagaaact caatctcaga aatcagagaa     5280

ctatcattgc atatacacta aattagagaa atattaaaag gctaagtaac atctgtggct     5340

taattaaggc gcgccgggcc cctacgtcac ccgccccgtt cccacgcccc gcgccacgtc     5400

acaaactcca ccccctcatt atcatattgg cttcaatcca aaataaggta tattattgat     5460

gatggccgca gcggccctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac     5520

agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg     5580

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     5640

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     5700

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     5760

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     5820

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     5880

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     5940

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa     6000

tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat     6060

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg     6120

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc     6180

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga     6240

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga     6300

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg     6360

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc     6420

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac     6480

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact     6540

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca     6600

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg     6660

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact     6720

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg     6780

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg     6840

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat     6900

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc     6960

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat     7020

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt     7080

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7140

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7200

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7260

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     7320

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7380

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7440

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7500

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     7560

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     7620

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     7680

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     7740

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7800

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7860

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7920

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7980

ttaatgcagg ggccgctgcg gccatcatca ataatatacc ttattttgga ttgaagccaa     8040

ta                                                                    8042


<210>  18
<211>  33057
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HD-delta-28E4-MAR-EF1a-optHumanEPO-1

<400>  18
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag      240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga      300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg      360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc      420

cgggtcaaag ttggcgtttt gatatcaagc ttatcgatac cgtaaacaag tctttaattc      480

aagcaagact ttaacaagtt aaaaggagct tatgggtagg aagtagtgtt atgatgtatg      540

ggcataaagg gttttaatgg gatagtgaaa atgtctataa taatacttaa atggctgccc      600

aatcacctac aggattgatg taaacatgga aaaggtcaaa aacttgggtc actaaaatag      660

atgattaatg gagaggatga ggttgatagt taaatgtaga taagtggtct tattctcaat      720

aaaaatgtga acataaggcg agtttctaca aagatggaca ggactcattc atgaaacagc      780

aaaaactgga catttgttct aatctttgaa gagtatgaaa aattcctatt ttaaaggtaa      840

aacagtaact cacaggaaat accaacccaa cataaaatca gaaacaatag tctaaagtaa      900

taaaaatcaa acgtttgcac gatcaaatta tgaatgaaat tcactactaa aattcacact      960

gattttgttt catccacagt gtcaatgttg tgatgcattt caattgtgtg acacaggcag     1020

actgtggatc aaaagtggtt tctggtgcga cttactctct tgagtatacc tgcagtcccc     1080

tttcttaagt gtgttaaaaa aaaaggggga tttcttcaat tcgccaatac tctagctctc     1140

catgtgcttt ctaggaaaca agtgttaacc caccttattt gtcaaaccta gctccaaagg     1200

acttttgact ccccacaaac cgatgtagct caagagaggg tatctgtcac cagtatgtat     1260

agtgaaaaaa gtatcccaag tcccaacagc aattcctaaa aggagtttat ttaaaaaacc     1320

acacacacct gtaaaataag tatatatcct ccaaggtgac tagttttaaa aaaacagtat     1380

tggctttgat gtaaagtact agtgaatatg ttagaaaaat ctcactgtaa ccaagtgaaa     1440

tgaaagcaag tatggtttgc agagattcaa agaaaatata agaaaaccta ctgttgccac     1500

taaaaagaat catatattaa atatactcac acaatagctc ttcagtctga taaaatctac     1560

agtcatagga atggatctat cactatttct attcagtgct ttgatgtaat ccagcaggtc     1620

agcaaagaat ttatagcccc ccttgagcac acagagggct acaatgtgat ggcctcccat     1680

ctccttcatc acatctcgag caagacgttc agtcctacag aaataaaatc aggaatttaa     1740

tagaaagttt catacattaa actttataac aaacacctct tagtcattaa acttccacac     1800

caacctgggc aatatagtga gaccccatgc ctgcaaaaaa aaaaaaatta gccaggcatg     1860

gtagcatgta cctgtagtcc cagctacttg agaggtgagg tgggaaaatc actttagtgc     1920

aggatgttga ggctggagtg aactgtgatt gtgccactgc actccagcct ggacaataga     1980

gcaagacctt gtctcaaaaa aatgcattaa aaattttttt taaatcttcc acgtatcaca     2040

tcctttgccc tcatgtttca taaggtaaaa aatttgatac cttcaaaaaa accaagcata     2100

ccactatcat aatttttttt aaatgcaaat aaaaacaaga taccattttc acctatcaga     2160

ctggcaggtt ctgattaaat gaaattttct ggataatata caatattaag agagactgta     2220

gaaactgggc cagtggctca tgcctgtaat cccagcactt tgggaggctg ggtaacatgg     2280

cgaaccctgt ttctacaaaa taaaaatatt agctgggagt ggtggcgcac acctatagtc     2340

ccagctactc aggaggctga ggtggaagga tcgcttgaac ccaggaggtt gagactgcag     2400

tgaactgtga tcattctgct gcactgcacc ccagcctggg caacagagac cttgtctcaa     2460

aaaaaaaaaa aaaagagaca aattgtgaag agaaaggtac tctcatataa catcaggagt     2520

ataaaatgat tcaacttctt agaggaaaat ttggcaatac caaaatattc aataaactct     2580

ttccccttga cccagaaatt ccacttgaat aaagctgaac aagtaccaaa catgtaaaag     2640

aatgtttctt ctagtacagt cggtaagaac aaaatagtgt ctatcaatag tggactggtt     2700

aaatcagtta tggtatctcc ataagacaga atgctatgca acctttaaaa tatattagat     2760

agctctagac acactaatat taaaagtgtc caataacatt taaaactata ctcatacgtt     2820

aaaatataaa tgtatatatg tacttttgca tatagtatac atgcataggc cagtgcttga     2880

gaagaaatgt gtacagaagg ctgaaaggag agaactttag tcttcttgtt tatggcctcc     2940

atagttagaa tattttataa cacaaatatt ttgatattat aattttaaaa taaaaacaca     3000

gaatagccag acatacaatg caagcattca ataccaggta aggtttttca ctgtaattga     3060

cttaacagaa aattttcaag ctagatgtgc ataataataa aaatctgacc ttgccttcat     3120

gtgattcagc cccagtccat taccctgttt aggactgaga aatgcaagac tctggctaga     3180

gttccttctt ccatctccct tcaatgttta ctttgttctg gtccctacag agtcccacta     3240

taccacaact gatactaagt aattagtaag gccctcctct tttattttta ataaagaaga     3300

ttttagaaag catcagttat ttaataagtt ggcctagttt atgttcaaat agcaagtact     3360

cagaacagct gctgatgttt gaaattaaca caagaaaaag taaaaaacct cattttaaga     3420

tcttacttac ctgtccataa ttagtccatg aggaataaac accctttcca aatcctcagc     3480

ataatgatta ggtatgcaaa ataaatcaag gtcataacct ggttcatcat cactaatctg     3540

aaaaagaaat atagctgttt caatgagagc attacaggat acaaacattt gattggatta     3600

agatgttaaa aaataacctt agtctatcag agaaatttag gtgtaagatg atattagtaa     3660

ctgttaactt tgtaggtatg ataatgaatt atgtaagaaa acaacaggcc gggcgggttg     3720

gttcacacgt gtaatcccag cactttggga ggctgaggca ggcagactgc ctgagctcag     3780

gagttcgaga ccagcctggg caacacggtg aaatcccgtc tctactaaaa atacaaaaaa     3840

attagccggg tgtggtgaca catgcctgta gtcccagcta cttgggaggc tgaggcagga     3900

gaatcacttg aacctgggag gtgaaggttg cagtgagcca agatggcacc acttcactcc     3960

agcctgggaa acagagcaag actctgtctc tgagctgaga tggcaccact tcactccagc     4020

ctgggaaaca gagcaagact ctgtctcaaa aaaaacaaaa cacacaaaca aaaaaacagg     4080

ctgggcgcgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggtggatc     4140

acctgaggtc aggagttcca gaccagcctt gtcaacatgg tgaaacctcc ccccgccgtc     4200

tctactaaaa atacaaaaat tagccaggcg tggtggcagg agcctgtaat cccagctact     4260

tgggaggctg aggcaggaga atcgcttgta cccagaaggc agaggttgca ctgagctgag     4320

atggcaccat tgcactccag cctgggggac aagagcgaga tttcgtcttt aaaaaacaaa     4380

aacaaaacaa aaaaccatgt aactatatgt cttagtcatc ttagtcaaga atgtagaagt     4440

aaagtgataa gatatggaat ttcctttagg tcacaaagag aaaaagaaaa attttaaaga     4500

gctaagacaa acgcagcaaa atctttatat ttaataatat tctaaacatg ggtgatgaac     4560

atacgggtat tcattatact attctctcca cttttgagta tgtttgaaaa tttagtaaaa     4620

caagttttaa cacactgtag tctaacaaga taaaatatca cactgaacag gaaaaactgg     4680

catggtgtgg tggctcacac ttgtaatccc agtgctttgg gaggctgaga caggagagtt     4740

gcttgaggcc aggagttcaa gaccgacatg gggaatgtag caagaccccg tccctacaaa     4800

aaactttgta aaaatttgcc aggtatggtg gtgcatacct gtagtcccag ctactcggga     4860

ggcggaggca gaaggaatca cttgagccca ggagtttgag gctgcagtga gctacgatca     4920

taccacagca ctccagcgtg gacaacagag taagacccta tctcaaaaac aaaacaaaac     4980

aaaacaaaca aaaaaaacca caagaaaaac tgctggctga tgcagcggct catgcctgta     5040

atcccagtat tttgggaggc ccaggtgggc gtatcacctg aggtcaggag ttagagacca     5100

gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcatgtg     5160

gcacgcgcct gtagtcccag ttactgggag gctgaagcag gaggatcacc tgagcccggg     5220

aggtggaggt tgcagtgagc cgagatcaca ccactgcact ccagcctggg tgacacagca     5280

ataccctacc tcaaaataaa aaagaaaaag aaaagaaaag ttgctgtccc cgctacccca     5340

atcccaaatc caaacagcct ctctcatctc acagtaaggg ggaaaaatca cccaaaaaag     5400

ctaagtgatc ttttgaaaac ccaaactctt agaagtctaa gattattata gtcaactcat     5460

gaagtgtcat cataaaagat actctaatat tatttaagta gaaccacata ttggttgtct     5520

tggtatgtct agcccctggc atacaaaata tttaataaca ctgatatggt acctgtgatg     5580

tgaaaatgta ctatgagtac agctttataa atactatata tgtacctata tacagaaaaa     5640

aatacaacaa aatcataaaa gcacttatct ttgaaagagg agttacagca attttattta     5700

gttctttatt gctttgctat atattctaaa tttttttcaa tgaatatata tcacttttaa     5760

aaaaattcaa tggtctttct tataaattat ctttggcagc atgcgttttt atatatacat     5820

ataaaatgta tgggaaattt ttaaaggata cattaaatta aagcaaaata tacaaacaaa     5880

aaatcagaat acaaaaagat aaaaagattg ggaagggagg gagggagtaa ggaggaaggg     5940

tgggtgggta tagagaaata taccaaataa tggtaagaag tggggtcttg acactttcta     6000

cacttttttt aaataaaaaa aatttttttc tctctctttt ttttttttag agacgaagtc     6060

tcgctatgtt gcccaggctg gtcttgaact cctgggatca agagatcctc ctgcctcagc     6120

ctcccaaggt gcttggatta caggtgtgag ccaccacgcc tggtcacttt ctacacttta     6180

atatatatat tttttcattt tcaatgtcat ttttattagt taatttataa tacccattca     6240

ccattatatt caaagtctat ttgaagaaat aaaccagaaa gaatgaaata ctctagctca     6300

catgctattc aatactaaat tacctttcaa atcacattca agaagctgat gatttaagct     6360

ttggcggttt ccaataaata ttggtcaaac cataattaaa tctcaatata tcagttagta     6420

cctattgagc atctcctttt acaacctaag cattgtatta ggtgcttaaa tacaagcagc     6480

ttgactttta atacatttaa aaatacatat ttaagactta aaatcttatt tatggaattc     6540

agttatattt tgaggtttcc agtgctgaga aatttgaggt ttgtgctgtc tttcagtccc     6600

caaagctcag ttctgagttc tcagactttg gtggaacttc atgtattgtc aggttggccc     6660

gtaatacctg tgggacaact tcagcccctg tgcacatggc caggaggctg gttgcaaaca     6720

ttttcaggta ggtggaccag gacatgcccc tggtcatggc caggtggagg catagtgcta     6780

tacagcaggc agaagtcaat attgatttgt ttttaaagaa acatgtacta ctttcataag     6840

cagaaaaaat ttctattctt gggggaaaag attatgccag atcctctagg attaaatgct     6900

gatgcatctg ctaaaccttc acatatcaga acatatttac tatagaaaga atgaaaatgg     6960

gacatttgtg tgtcacctat gtgaacattc caaaaatatt ttacaacaac taagtatttt     7020

ataaatttta tgaactgaaa tttagttcaa gttctaggaa aatacaaacc ttgctagata     7080

ttataaaaat gatacaatat atattcattt caggctcatc agaatatatc tgttatcact     7140

tgacaagaat gaaaatgcac cattttgtag tgctttaaaa tcaggaagat ccagagtact     7200

aaaaatgact tcttccttga agcttactca ccaacttcct cccagttact cactgcttct     7260

gccacaagca taaactagga cccagccaga actcccttga aatatacact tgcaacgatt     7320

actgcatcta tcaaaatggt tcagtgcctg gctacaggtt ctgcagatcg actaagaatt     7380

tgaaaagtct tgtttatttc aaaggaagcc catgtgaatt ctgcccagag ttcatcccag     7440

atatgcagtc taagaataca gacagatcag cagagatgta ttctaaaaca ggaattctgg     7500

caatataaca aattgatttc caatcaaaac agatttacat accatactta tgtcaagaag     7560

ttgttttgtt ttattgcatc ctagatttta tttttttgat ttatggttta ctttaagcat     7620

aaaaaatttg tcaatacaac tcttcccaaa aggcataaac aaaaattcat aaaacttgca     7680

tcacttgaga tacttcaggt atgaattcac aactttgtta caacttacta tatatatgca     7740

cacatatata tatatttggg tatattgggg gggttctaat ttaagaaatg cataattggc     7800

tatagacaga cagttgtcag aacttggcaa tgggtacgtg caggttcatt ataccaagtc     7860

tacttgtagt tgttcaaaat gtatcataat acaaggccgg gcgaggtcgt cacgcctgta     7920

atcccagcat tttgggaggc taaggcagga ggattgcttg aggtcaggag tttgtgacca     7980

gcctgggcaa cagagcaaga ccctgtctcc aaaaagaaaa aaaataattt tttacaaaat     8040

aaaaacaaaa tgtatcatca gacgaaatta aataagaggc aattcattta aatgacaact     8100

tttcccagct tgacatttaa caaaaagtct aagtcctctt aattcatatt taatgatcaa     8160

atatcaaata ctaatttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc     8220

caggctggag tgcagtggcg cgatcctggc tcactgcaag ctccgcctcc cgggttcacg     8280

ccattctcct gcctcagcct cccgagtagc tgggattaca gacatgcgcc accacgcccg     8340

gctaattttg tatttttagt agagatgggg tttctccatg ttggtcaggc tggtcttgaa     8400

tttcccacct caggtgatct gcctgcctca gcctcacaaa gcagtagctg ggactacagg     8460

cacccaccac cacacttggt taattctttt gtattttttt tgtaaagacg ggatttcacc     8520

atgttagcca ggatggtctc gatctcctga tctcatgatc cgcccgcctc agcctcccaa     8580

agtgctggga ttacaggcgt gagccacccc gcccggccat caaatactaa ttcttaaatg     8640

gtaaggaccc actattcaga acctgtatcc ttatcactaa tatgcaaata tttattgaat     8700

acttactatg tcatgcatac tagagagagt tagataaatt tgatacagct accctcacag     8760

aacttacagt gtaatagatg gcatgacatg tacatgagta actgtgaaca gtgttaaatt     8820

gctatttaaa aaaaaagacg gctgggcgct gtggctcatg cctgtaatcc cagcactttg     8880

ggaggccaag gcaagttgat cgctcgaggt caagagttcg agaccagcct ggccaacgtg     8940

gtaaaacccc gtctctacta aaaatacaaa aaaaaaatta gccaggcatg gtggcacagg     9000

cctgtaatcc cagctactag ggaggctgag acatggagaa ctgcttgaat ccaggaggca     9060

gaggttacag tgagccgaga tcataccact acactccagc ctgagtgaca gagcgagact     9120

cctgtctaaa aaaaaaaaaa aaaaaaaaga tacaggttaa gtgttatggt agttgaagag     9180

agaactcaaa ctctgtctca gaagcctcac ttgcatgtgg accactgata tgaaataata     9240

taaataggta taattcaata aataggaact tcagttttaa tcatcccaaa caccaaaact     9300

tcctatcaaa caggtccaat aaactcaatc tctataagag ctagacagaa atctacttgg     9360

tggcctataa tcttattagc ccttacttgt cccatctgat attaattaac cccatctaat     9420

atggattagt taacaatcca gtggctgctt tgacaggaac agttggagag agttggggat     9480

tgcaacatat tcaattatac aaaaatgcat tcagcatcta ccttgattaa ggcagtgtgc     9540

aacagaattt gcaggagagt aaaagaatga ttataaattt acaaccctta aagagctata     9600

gctgggcgtg gtggctcatg cctgtaaatc ccagcacttt gggaggctga ggcgggtgga     9660

tcacctgagg ccagaagttc aagaccagcc tagccaacat ggcgaaaccc tgtctctaca     9720

aaaaatacaa aaattagccg ggtgtggtgg cacgtgcctg tagtcccagt tacttgggag     9780

gccgaggcag gagaatcgct tgaacctagg aggtggaggc tgcagtgagc cgagattgtg     9840

ccactgcact ccacttcagc ctgggcgaca agagcaagac tccgtcacaa aaaaaaaaaa     9900

aaaaaaaaag cttaaaatct agtgggaaag gcatatatac atacaactaa ctgtatagca     9960

taataaagct cataatctgt aacaaaatct aattcgacaa gcccagaaac ttgtgattta    10020

ccaaaaacag ttatatatac acaaaaagta aacctagaac ccaaagttac ccagcaccaa    10080

tgattctctc cctaagcagt atcaagttta aagcagtgat tacattctac tgcctagatt    10140

gtaaactgag taaaggagac cagcaccttt ctgctactga actagcacag ccgtgtaaac    10200

caacaaggca atggcagtgc ccaactttct gtatgaatat aagttacatc tgttttatta    10260

tttgtgactt ggtgttgcat gtggttatta tcaacacctt ctgaaagaac aactacctgc    10320

tcaggctgcc ataacaaaat accacagact gagtgactta acagaaactt atttctcaca    10380

gttttggagg ctgggaagtc caaaattaag gtacctgcaa ggtaggtttc aatctcaggc    10440

ctcttctttg gcttgaaggt cttctaactg tgtgctcaca tgacctcttc taacaagctc    10500

tctggtgtct cttttttttt ttttttcttt tttgagacag agtctcactc tgtcacccag    10560

gctggagtac agtggcacaa tctgggctca ctgcaacctc caactcccgg gttcaagtga    10620

ttctcatgcc tcaccctccc gagtagcttg gatgacagga gcccgctacc acacccagct    10680

aatttttgta tttttagtag agatggtgtt tcactacatt ggccaggctg gtctcaaact    10740

cctgacctcg tgatccaccc accttggcct cccaaagtgc tgggattaca ggtgtgagcc    10800

actgcgcccg tcctggtgtc ttttcatata agggcactaa tccaatcaga cctgggccca    10860

accctcccga cttcttctaa ctgtaattac cttccaaagg ccctgtctcc aaataccatc    10920

acactggggg ttaggacttc aaaaaaggta tggggggggt gtgggaggac ataaatgctc    10980

agtccataac aagcacccaa cataaaaatg gctagaacag atcacaaaaa aaaggtcctg    11040

tatggctttg gggaagggct caaccccaaa atatctgaga gctctggagg ggcctagaag    11100

tggtaaatga atgaaaacgt ggttactctc cagatctgcc tttcccaaat atggccattc    11160

ttggctgaat cagaaatcaa aggacaggtt attaattact agctctaagt tacttaccat    11220

ttgctgagac agttcagaaa tctgactgca tctcctcaga gatctagaac acagttctca    11280

aattctaact tacttgtgat atacttgtga atgataaaaa tcgctacagg tacttttatt    11340

aatctgaaag agtattgaga aattaccttt cattctgact tttgtctgga atgaaaatca    11400

atacttttgc tataatcgat tactgaaata attttacttt ccagtaaaac tggcattata    11460

atttttttta atttttaaaa cttcataatt ttttgccaga ctgacccatg taaacataca    11520

aattactaat aattatgcac gtcacatctg taataatggc cttcatgtaa acatttttgt    11580

ggtttacaca taaaatctct aattacaaag ctatattatc taaaattaca gtaagcaaga    11640

aaattaatcc aagctaagac aatacttgca acatcaattc atcatctgtg acaaggactg    11700

cttaagtctc tttgtggtta aaaaggaaaa aaaaaaaaaa gacatgttgg ccagatgcgg    11760

tggctcacac ctgtaatccc agcactttgg gaggctgagg tgggcggatc acccctggcc    11820

tgcccaacat ggtgaaaccc cgtctctact aaaaacacaa aaattagctg ggcgtggtgg    11880

cgggcgcctg taattccagc tactcgggag gctgaggcag gagaattgct agaacccagg    11940

aggcagagat tgcagtgagc tgagattgca ccattgcact acagtctggg caacaaaagt    12000

gaaactccat cttaaaaaaa aaaagacaat gttcgtgggt ccaaacaaga cttaatggaa    12060

gtgagtctaa aaatgagcta tgtgggccag gcgtagtggc tcccacctgt aatcccagca    12120

ctttgggagg ccgaagcagg cagatcatga ggtcaggaga tggagaccat cctggccaac    12180

acggtgaaat cctgtctcta caaaaattag ctgggcgtgg tggtgcctgc ctgtaatccc    12240

agctactcag aaggctcagg caggagaatc gcttgaacca gggagtcggt ggctagagtg    12300

agccgagatt tgcatcactg cactcctgcc tggtgacaga gcaagactcc atctcaaaaa    12360

aaacaaacaa aaataaaaga taaaaatgag ctatgtgaat taaaagaggt ataacaatag    12420

ataaaccata ttttatttaa ttcctagtaa tgagtaatat ttccaaactt ctggaatggg    12480

cagaaattgc tagttggcat atttttacct tttatattca gatacattaa aattctcaaa    12540

aaaaaacacc tcaaagcaga tgatccgcca tctccttgga taatttgtgt taactcagga    12600

taacagaaaa ccaaaattat gagttactga tgcaatattc ctaaatgtaa aaataattaa    12660

agctaatagt agattcatct tccaatttca tatcagtctt acaaataaac tacatatata    12720

acttgcttgc cttcccttct gagggataaa gctgttagaa gaattaaaat cagcattctt    12780

gactattcaa ccaagggagg gataaattat tactcattct agggacatgg gctcataact    12840

actacatgtg taaggacatg aatttaccca atattacaat ttttcctttt attagtgtgt    12900

acagtggaag aatagacatg ttcactctgg acaaaaaaaa aattatactt atcagttatc    12960

agaagcacaa tgctgaagac agtagttcca taacaatttg aagtatgtga tcgaactagt    13020

agattatctt agtagtagtg aattattgta aatgttagta atttggcagc cactgggcag    13080

aaaaataaga attgaggctc aatattgata ttaatggtgg tgattgacac ataaatttta    13140

tcaagtctac acaatataaa attacagaaa ggtagaagag tataccagta caacttcaac    13200

atatcttcac tacaagggag taaaatgaca tggcctagtt actatctaat gaactgcaga    13260

aaactaaaag aaaactccaa ggcaactctt ctctgctgat ctggttggtc cttttcctac    13320

cttttgcaat acccagatac aaacaatgga tagaaaacaa agtagacttg tagtatgcag    13380

gtcacagtgc taaattcaca gaaagaaacc cctgaactga actgctctat ttcctggtgg    13440

tcacaaagag taattctggt ttacacctac agattgatgt caatctacac cctgttgata    13500

acagtgtggc caaggacaaa aaaaaggtgc tccgttttac caattctgta aaaaattatt    13560

ggcagggtaa gctcggctag ggcaggatta catttctagg actaccatcc ccgaaattta    13620

gaagatatta tatccacata aagcatatct ttcacattaa tttgcaaaaa tctaaaagct    13680

ttttcttagc tcaagtgtgt ccaagtttac cctggcagtt taaaacgata gttacaagca    13740

gcatgggttg tatcagacac atttgagggc caatttcatg taagtgatat tgggcaagtt    13800

acttcaacta tctgtgcctc caaggtcata ctagtgttta tttacctaaa gggtacctgt    13860

tatgtaactt tagggtgttt acattagata atgcctgcaa aatatttact tcaacgccta    13920

aaacatagtt aagtattcaa taaataccta ctattgtcac tactaactta aaagtttaga    13980

gattaagagc agaatctggg gtgagacaaa cttaggttca aatcctagta ttgttgggta    14040

atcttgggca agttacttaa cctctctgat ttgtgtaatt taaaaaatta gttaatatac    14100

ataacagggc ttagaagagt atctagcaca tagcaccatt taagcatttg ttattgctaa    14160

catgcaaaca atttaaggga aagaaatttt ttaaaaagga agagggattt gcaaactaaa    14220

aacaatgagt atcttatgtt caaagaaaac taacaaacag ccagctctag caataattaa    14280

attcactata tactggggca ggcatcacac cccaaagcta aaagcgtcta cctaggccag    14340

gcacggtggc tcatgcctgt aatcccagca ctttgggaag cagaggcggg cagatcgctt    14400

gagctcagga gttcaagacc agcctggaca acatggcaaa acaccatctc tacaaaaaat    14460

acaaatatta ggccgggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccaa    14520

ggcgggtgga tcacctgaga tcaggagttc gagagtagcc tggccaacat ggtgaaacct    14580

cgtctctatt aaaaatacaa aaaattagcc aggcatggtg gcaggcgcct gtaatcccag    14640

ctactcaggg ggatgaggta ggagaatcgc ttgaacccgg gaggcagagg ttgcactgag    14700

ccgagatcat gccactgtac tccagcccgg gcaacaagag cgaaactcca tctcaaaaaa    14760

taaataaata aataaataaa ataaagtaca aatattagcc agggatggtg gtgcgcacct    14820

gtagtcccag ctacttggga ggctgaagtg ggagaatccc ctgagcctgg ggagaatcac    14880

ccgagcccgg gaagtcgagg ctgcagtgag cagtgattgt gccactgcac tccatcctag    14940

gtgacagagt gagaccctgt ctcaaaaaaa agaaattggc agaattaagt aagttgatgt    15000

ttagagatga aaaatcaaca ttttttcctc agcaactgaa taaaaacaac agccactacc    15060

atttttttga gtacctattt gtagcctatt ttttaactgg tattactcga gagagagaga    15120

gctaggttcg agacagagct ccttctctta ataactgtat gacctagggt atgtctgtta    15180

gcctctctga ggcttcaaag gttcctcatc tgtaaaatgg taataatcat accattgcta    15240

cagggctgtt ttgaagacta attaggacta tgtaagtaaa catgatgatg gctattatta    15300

ctgttccccg ccaggggcca tgcaagggtt gctgattcac atagactgtc ttataatcct    15360

ctcaataact ccaagaggta gccagcacct cagatataca taaaatgact taagcccaga    15420

gaggtgaagt aagttgccca cagccacaca actagtaaat agcccaaaca agctggattc    15480

ccagttagac tccgttaata gcactgctct ttaccttaag tcattacaat gcctaatatg    15540

aaatagaatc gcttctttct tagggttcaa gtggttaatt atttaatgta ttcattcaac    15600

aaaccatcat cgaggacctc ttacaagcca agtactgtgc taagtgctag agttacggcg    15660

gtgattcctg cccttaaaaa gttttagtgg gagaaacaac aggtaaccag gtcattgcca    15720

aaacaacaaa aataatcata ataaagcagg ctaaagcata tttaactggc cggggttttg    15780

actattttag caagcatgat cagaacggtt gaggagggag gccagcagct tggccggttc    15840

aacaaacaag aaaaaaccag tgagggtgga gctaagatac cagaggctga ttacggttaa    15900

gaatgttctt gaaggtaagg accagattct cattttctat atcctggggc atcggtcagc    15960

atggaatctg gattctagca catgtgaatt tcggcttgaa atgacctaat gccttttccc    16020

tagttccttc gtgtgtcaaa tacgcatggt taccgctacc agagctgtag tggggcttca    16080

atgaggccat gagcatctcc ataaagatga actacagtgt gtgcaaaact aaaggcaaaa    16140

cctggtcccc acacgccctc ccaggtggtc gctttccgtg ccgaggcccc tccagaggtg    16200

ccccgagaac ctcaccatcg caccccaaac ttccagggaa gggcctctcc cgagaaagcc    16260

cccacgcccc caccccgcgc catcattccc gaatctgccc tcggcccctc cccgcagcac    16320

gctcgcaggc ggcacatgtc aaccaaaacg ccatttccac cttctcttcc cacacgcagt    16380

cctcttttcc cagggctccc ccgaggaggg acccacccca aaccccgcca ttccgtcctc    16440

cctgccgccc tcgcgtgacg taaagccgaa cccgggaaac tggccgcccc cgcctgcggg    16500

gttccctggg cccggccgct ctagaactag tggatcccaa ttgaaggcct ggtctaaatg    16560

actccaaaat caccacttaa ttcaagagac tgatttccct gagtcaggcc ccttaaagca    16620

gctatttcaa tgggacaggg aaacaaccct aggatctgga ttagaatcac ttgggggctg    16680

ccacaccccc agggctctga tcctgccctt ctcccacacg cacattcaca tactgctgca    16740

gtgaccttcc atttctaatg ggttcctggg ccatctgtca ggtataggga atggaaaagg    16800

ggttggggag gctctgcttc agaaagtttg tgtcaggggc tcccagagcc tccacagata    16860

gatagcaggg gtccccaccc taccatggca gctataaatg tgatcaacat ttattggcct    16920

aggatacagc agttagcaaa atgcctgatg tagttcccac tccgtggagg ttgcaggcta    16980

gccaagaagt catgagttca gcaaccctta cgcaccagtg ggatgagatt ggaccaggcc    17040

gagggtagtc ttgggaacac tcagcatttg tctgagggcc agaagaggct gcttgccctc    17100

agacaggagg tcagcatctt tattgtagcc catgacacct ctacaccatt gctcttctgg    17160

tcttatggaa gacatctttg ggcctgataa cagcggagtc tgtgtcccac ttgtccaggc    17220

tggagtgcca catcaggcac actccagttg cagggacagc acagacaagt ttcaggaagg    17280

ctggtggcct ccaggaggtt aaccttataa ggccagattg taacctagtt gaaaaacata    17340

cacatgccat gataataaaa gaacctaggc accattacaa gagaaaaaat catttttgta    17400

gatacgagca tggattcttg ggtgggtcag acacactggg cttgtgctct gactgcactg    17460

tctcccctac ctgaccttgg gtaaaccata agactgctgc atgactcagt gtccacccca    17520

aaaaagtacc ggtagatatt ggccacagta gatatcagct agagtggact ctcatgacaa    17580

tgaggggaga tgtattcccc atcttaggca cctgggactc taccttccat cttctgctcc    17640

gtgtctctcc atccccaggc tcttcagaac tcagggagtc cagaatgtca gctcccagat    17700

ttcagccttc agaaaggaaa cccattaccg ttcagttgaa caaatgttgt ctgagcccca    17760

gatctgggct cagaggccat ctaggctatg agacaagagg ggaacaaagc accgtctgca    17820

ctcactcacc acactcactt gctgtcccag gtcacatcca tcgggtagag aatctaagag    17880

gctgagctag ctcccgccac cagcccagcc caccccacct ggccccttcc ttccttctac    17940

aaaatatgca ccacctgtca aagggtgggc agtgccaggc ctgcatacag agcactgagt    18000

gtaaaagcag acatggaccc tgacctccag gagcttccaa ttttcttgaa gagacaaatc    18060

agctggcatt tcagtccagt gtgatctgct cttggtgagc acagacctag ggagttgggg    18120

cagcttccca gaagaactgc agtccaggct gagggcagag aaatgagggg aatggcgagg    18180

aattggggag caggggggag ctcagtagag agccaagggc gggaggtgag aagtccgtgt    18240

tgggccagga gctaccctcc ggtggccaca gccgaagtcg aggatgcctt tggaactcat    18300

ccccacttct ctctttctgt atgtagccgt ccaagaacaa gtcacctcca agtgtagccg    18360

gatcaaggca agccccccat ctagcaagca cttgatgcca cccagaactg ggcttcttca    18420

gaacaatctg agtccaggaa tgatcccact caccaggcac cagagctgcg agggcatggg    18480

agtgatctca ccaactctgg ggaagcggca aggaattttc acctccagcc cccagtgtcc    18540

catcctctca cactcaggcc agactcccct gggcagactt gactctgtct gccagcatat    18600

gcagagcccc aaggccaccc caccagaagt gcccctgcct gggttctgtc ccagctccct    18660

gggcacccag tccttgagtc cccaccagct cagacggcct agtgtgccaa gaatgcccac    18720

tgcgttcaac aatgctgcat gggtcacagc ggcagcagct gtgaccacag cagtttcggg    18780

gaaaacaccc ctcagccaag tggataatag cgttcagcag cactcacctt ctggccaggc    18840

ctgccttcag aggccatctg attgggaggc acaagtgccc gctgcgatgg gaacacaagt    18900

gcccctggcc aacaacccca gcttcagcct gctgggcagc cagagcctca ggcagagccc    18960

ggtacagggc ccggtgcctg tagcaaacac caccaagttc ctccagcagg gtatggccag    19020

ctttagtccc ctgagcccca tacagggcat cgagccacca agctatgtgg ctgctgctgc    19080

caccgctgct gctgcttctg ccgttgctgc cagccagttc ccaggtccgt tcgacagaac    19140

ggatattccc cctgagctgc cacctgccga ctttttgcgc cagccccaac ccccactaaa    19200

tgatctgatt tcgtcacctg actgcaatga ggtagatttc attgaagctc tcttgaaagg    19260

ctcctgtgtg agcccagatg aagactgggt gtgcaacttg aggctgatcg acgacatttt    19320

ggaacagcat gctgctgctc aaaatgccac agcccagaat tctgggcaag tcacccagga    19380

tgctggggca ctttaaatct gagcaggatg cccatagaaa cccccatggt gacatcactc    19440

taggaagtgg tgtcgatcca tacccgcagt tgtctcccgt tacaatttga gtggtgttgt    19500

cagcccatgc ttatccctct ctctacctgt gacaaaatgg aaagctggtg atttttcaag    19560

ctacgtgtac atatttgaaa attttgtaaa tggttttcct aaacattaat gacagaagta    19620

tttatacttc attttgtgac tttgtaaata aagcgacggc ttttgtttca gtagagttgt    19680

gtttactatg cattgttttg tgtttattat acaatgttac aaatatgcag accgtgttgt    19740

ttgctccagt gataccttgt taagctaggt ggctgagtcg cttatggttt taatgcaatg    19800

agcaatgtgg atatgaccaa gagttgttgt gcaagttgac aaatgccaaa tagaaaacca    19860

cttggccatt tatttctatg ttcactaaaa atcctattgc cttgtgtgat tcttaatctc    19920

ttttgcgaac ctttcagtct ccgctagctc tttcctaatg agctttacag cagaagctgt    19980

tttatcgtta agtgccccac agagacactt taccaggagg ctgggagagt tctccagatt    20040

tgggagaggc gcagagacag tgtgtgagcc gagccctgtc tcagcaatcc acctggagga    20100

gctagagtat cctcctccct ttaccattca gaccgagaga aaaagcccag cttgtgtgca    20160

ccctcgtggg gttaaggcga gctgttcctg gtttaaagcc tttcagtatt tgttttgatg    20220

taaggctctg tggtttgggg gggaacatct gtaaacatta ttagttgatt tggggtttgt    20280

ctttgatggt ttctatctgc aattatcgtc atgtatattt aagtgtctgt tatagaaaac    20340

ccacacccac tgtcctgtaa acttttctca gtgtccagac tttctgtaat cacattttaa    20400

ttgccacctc gtatttcacc tctacatttg aaatctggcg tctgtttcaa gccagtgtgt    20460

tttttcttcg ttctgtaata aacagccagg agaaaagtgc ctctatgttt ttatttttca    20520

agggagtatt cagtacctac aaacccaagt caggaagcct gctagtggct ttggttcttt    20580

cagaggctgc tcgatgcctt gtgtgtcaga aagaaagatt cagcagtttt gcatcatggc    20640

aaagaagcct gttattttgg ggctcagccc ctcattttat agaggatgaa acagaggggg    20700

atgggaggtc acaaagacaa ctgccccggg agcaggtgtg ggggagactt gccctgaggg    20760

tctagacgct ctgcaccacc gtcctgtctc ccttgctgaa gaccacacat gcccttcttt    20820

gaccagaccc tgccacctga taggccagga cctggtaggc gggtacccag gtttcatgga    20880

tggaaccaca tctccccaaa agtggggagg tagctactgg gatgcacgcc tcccgccatg    20940

tgctatagga gagcagctga agcaacagtt gggatcagat gtagtcacaa ttgaatgcat    21000

catcacattt atccctctaa gtggctggga gagttgatat cctcatccct aaggtacaaa    21060

atgttccaat ttgatcagtg gctttcagga gctgagaaag gcatgtgctc tgaggcagag    21120

ctgttatgtc ccgcagagcc taaaaatgct ctaagaacat gctccctgcc aaaattctca    21180

atggctgtga caagggacaa cgatcgacca atgggggtgg aagcagacct ccgcagtcca    21240

ggggccagag ctaggacaga ggggtcggag aaagagtcat tttcccaaca ctccagctct    21300

tggccagtcc tcacacagtc ccctcctgct tcctgctgag agagatatcc tcataggtct    21360

gggtaaagtc cttcagtcag ctttcattcc ctgtcaccaa ctttgtctct gttctccctg    21420

cccgtctcag gcagcactcc tcaggaaacc tctccaagag ccagcctcac tgcagcgccc    21480

actattgtcc ctctgcctca agtgtcccat ccatgccagg ccccaggcag gctgcagctt    21540

tccctcaggg ccacaccaaa gcacttgggc tcagctgtgc tgtccccctc catcactgag    21600

ctcaggggca gcaggggtgg ggtgccagga ggcccattca cccttctctg gctctgtgtt    21660

ggacccacct gcccagccac tgctgcttag aacctacccg ctgggaaaat gaagccctcc    21720

cggaggggcc acctcaacct gagagcctca cggatcacag ttgtccccac tcagctctgc    21780

cagccctcag agacccatag ataaaagctg agcttggctc gcagagctgg ttccatcttc    21840

cattcccaga gggttcaact tcctacccca accacacagg gaacctcaag gctgagccag    21900

tgtgggctgc agtgcagacc agcttcctgg acacgtcctg ccacctgacc ccaggctggc    21960

ctcactgccc ctggcactcc tgaccctatc ctcattcctc ctggcagtgc gtgttctgcc    22020

attccgcttt cccttagctg tcctctcact gtactgtcag cttctccttt tccaggtgcc    22080

ccccaggggc tttccacatg accctgtcac cccacagccc atccagcacc aattccagct    22140

ctctgccacc cttcaaagga gtgacagtgc cctgcttcac ctcccactca cccctcaacc    22200

cagagcaatc tggctccagt cttgcctcct tccccctaag tactctagtc acagttccaa    22260

attcctcctg gtcataaagc caaatgaagc ttcctggtcc tcagcggact tgccacttca    22320

gcagtactgg actctctcct cccagaaacc tgtttcccct tggctcctgg agcccacact    22380

ctgctggaat ccttctgcct ctctggcctg tagcctggcc ctctctccca acctgaggtc    22440

cattctctcc tgctcctcca caagatgttg ctccttccat tacttcctcc ctctcaacca    22500

aagctccttc attagctctt tatcttctgg tttcttcccc tgggcagacg aatggattca    22560

agagcctgtg gcccagcagc ccagcactcc aggatctcag cacttcagca tcccagtacc    22620

ctagcatctc aataccccag caccccagca ccatagtatt ccagcacccc attgtccaag    22680

catctcagca ctccagcatc ccagcacccc aacactccag cagcccagaa tctcagcacc    22740

ctagcactgc agcatctcag gaccccagca cttcagcatc ccagcacact agtactccag    22800

catctcggca ccccagcacc taggcatccc aacacccagc accccagcac ttaagcatcc    22860

caccactaca gtatctcaac actccagcac cccagcacca tagtgttcca gcaccccagc    22920

atcccaacac cccagcactt aagcatccca acacctcggc atcccaacac cccagcactg    22980

cagcatctca gcaccttagc atcccagtgc cctagcatct caatgctcca gcacaccagt    23040

actacagtat tccagcaccc cagcactcca gcatctcagc actgcagcac tgcagcactc    23100

cagcatccca aaatcccagc atcccaacac cccagcagac cagcagacca gcatctcagc    23160

accgcagcat ccaaggacta tcccagcatc ccagcaaccc agcacctcag catcccaaca    23220

ccccagcatt tcagcatggc aacaccccag taccccagca cttcagcacc ccagtatccc    23280

agcatctcag cgacccagta tcacaaaacc tcagcatcct agcaccccag caccccagca    23340

ccttagcacc ttagcatccc agcatctcag cgcctcagca tcttgatatt ctggctgagg    23400

tcagcgtggt gtatctagtc agggtcctaa ctttcacttc gcagggaaat gctgctggac    23460

tgggtctcat gttgggctga agctctctag accccttgaa gacagcataa aagagcttgg    23520

agacgctggg tgtcccccat ggaagagttc actctcatcc tgctttgaca acagccttct    23580

ctggggtccc tcacgggccc ctctttctta ctgcaagttt gtctctgaga agactgtgat    23640

gcagaagtca ctcagctgcc tgtggctcct gaagagctga aggtggaggc ctgtaggcct    23700

ccctatgaga ggcgcagaaa aaaccatgat tgctagtggg gaggtgctcc ctctacaacc    23760

cactccataa tctgcccccg cccagctctg aggccagccc caggggaaaa tgccagatcc    23820

ccagggaggt gtgtgagacc tcaggggctc cctcctccct tacagcaggc tcaggcccct    23880

gggggcctca gggccaaggt ctgtgggtaa gctactatct ctcacttgtc ctctagccac    23940

aaaagccagg gagatctggc aatggacatg aggttctgaa gaagcacata tgactggctt    24000

cctaatgcgt ggttgttcag tgattcaata aacacgcatg ggccaggcat ggggaaatag    24060

acaaacatga tccccaacct ctcccagagt gaactgggag ggaggagtgt tcatccctca    24120

ggattacacc agagaaacaa accagcagga gatatatatg gttttggggg gtcaagaaag    24180

aggaaaaacc tggcaaggca agtccaaaat cataggacag gctgtcagga agggcagcct    24240

ggaacctctc aagcaggagc tgatgctgca gtccacaggc agaatttctt cttcctcggg    24300

gaaatctcag ctttgttctt aaggcctttc aactgattgg ctgaggtctg ccccttcccc    24360

cacattctcc aggataatct tccttactta aagtcaacta ttaatcacag ctacaaaatc    24420

ccttcacagc tacacataga tcagtgtttg attgacgaac agcccctaca gcctagccaa    24480

gttgacacat aaaactaacc atcacagggg gacaaatgat gtaaacacat caacaaataa    24540

aacagtaaca agttaaggtc tatggaaaaa acacagaagg ggcagagaga aagaaagcaa    24600

gaaggagagt cccagtttgc tagggcttgt gggaagtggg gagcagttct ctttagctag    24660

gatatttggg aaaggcatat ctgaaggagt gatatttgag cttagattaa aagatgggaa    24720

ggagcaagcc atgcaaagag ctaggatgtt ccaagcagag acggaacagc aagtgcaaat    24780

gtcaggagga atagaaggag gctggtgggt ggggtccagt gagcaagagg agggcaggca    24840

ggagagggga tggggaggtg ggcaggccca gaccacccag ggccctggag actatcctga    24900

tccaacaagg gaagccttga gtcacttcag tgtccatgtg gagaatggac ctcagactga    24960

atgagggagg cagtaaggag ggcctctacc tccagggctt cgccctgtgg actgcgcata    25020

gacatctcca actcagaaag tctgaaccaa actttccata gttcccccaa gtctgggcat    25080

cctcctactc agtgaaaggc agccatcaca cctccctgcc ctgctcccgg atgccccaaa    25140

tcctcttggt ctccaagtcc agaacctgag acttgtcctt gatgtttgtc tttccctcac    25200

cctttctgta ttctgggaag atgggttttt ttcccccaga tgaatctgta aaacttctgt    25260

gatcacaata aaaattctgg cagtattatt ttctggaaca tgacaaagtg attcaaaatt    25320

atttatctgg aagactacaa aacaagaata gccaggaaat ttctaaaaag aaagaagaag    25380

gaggaggaga aagaaggagg aggaaaagga ggagaagaag aaaagaaaaa gaaccaagaa    25440

agggttctag ctctaccaaa tattaaaaca tatcatgaag ctatttaaaa caatatggtt    25500

gtggatactg aaaaagatgt gaataaagtg gaaggaaaat aaatagaaat gcacatgggg    25560

attgagactg tgaaaaaggc agcatctcac atcagtgagg gatgttcaac acctggtgtt    25620

gggaaaactg gctagtcatt taaaccaaac aactgggtcc tctacctcac tcctgacatt    25680

aagatacatt tagatgattc aaagagtaag acagaaaaaa taacacgtga aaacactatc    25740

agaaaacaac gtgggccagg tgtggtgggt cacgcctgta atcccagcac tttgggaggc    25800

cgaggcagac agatcacctg aggtggggag ttcaagacca gcctgaccaa catggtgaaa    25860

tcctgtctct actaaaaata caaaattagc tgagcgtggt ggcgcatgcc tgtaatccca    25920

gctactcagg aggccgaggc aggagaatca cttgaacctg ggaggcagag gttgtggtga    25980

gccgagatca cgccattgca ctccagcctg ggcaacaaga gtgaaaatcc atctaaaaaa    26040

aaaaaaaaaa gccaaggtgg atatttttat agtatcaggg tagatcaagc ttctccaatc    26100

atgacatgaa acccagaaac cataaaagaa aagaatgata aaattgccca cgtaaagtaa    26160

aaagcttgca cacagaaaaa caccatacag gttacaagat gagcagcaaa atcagagaaa    26220

aaacattgca attcaggaca cacagaggct attgttccta atatttaaaa ataaaagtag    26280

tggattgtct acaaaaagat gaagacaaga atttcagaaa accaaatact gcatgttttc    26340

acttacaagt ggaagctaaa cactgagtac acgtgtacac aaagaatgga accataggcc    26400

aggcaccgtg gctcacgcct gtaatcccag tactttgcga ggccgaagcg ggcggatcac    26460

ctgaggtgag gagttcgaga ccatcctggc caacatggtg aaacccagtc tctactaaaa    26520

atacaaaaat tagccgggcg tggtggtggg tgcctgtaat cccagctact cgggaggctg    26580

cggcagtaga atcgcttgaa ccctggaggt ggaccttgca gtgagccgag atcgcaccac    26640

tgcactccag cctgggcaac agagtgagac tccatctcaa aaaaaaaaaa aaggaataga    26700

acaatagaca ctggggccta cttgagggag gagggtgagg atcaaaaacc tgcctatcag    26760

gtactatgct tattacctgg gtggtgaaat aatctgtaca ccaaacccca gtgacatgca    26820

atttaccgat gtaacaaacc tgcccatgta cccgctgaac ctaaaataaa agttggaaaa    26880

aaatatagaa attttctttg taatagccaa aaactgcaaa cagcccaggt gtctattagt    26940

agaatgcata aacaaactcg ggcatgttca tacaatgtaa aactactcat caataaaaag    27000

tgatacttct cagcaatgaa aagaaactag ctactgatac cagctacaac atggatggat    27060

ttcaagtgct ttatgatgag agcaagaagc cagacacaaa agtgtctata tatatataca    27120

gtatatatac gtatatatac acatatatac agtatatata tacatataca tgtatatata    27180

tactgtatat atactgtata tatatacaca gtatatatat acatatatac agtgtatata    27240

tactgtgtat atatacatgt atatatactg tgtatatata catgtatata tactgtgtat    27300

atatacatgt atatatactg tgtatatata catgtatata tatgtatact gtatatatac    27360

tgtatatata tatacacata tatacagtat atatatacag tatatactgt atatatacag    27420

tatatacgtg tatatataca tatatacagt atatatgtaa atatacatat atacagtata    27480

tatgtaaata tacatatata catgtatata tatacactat atatatacat atatagtgta    27540

tatatacata tatacatgta tatatttact atatgattcc atttatataa agtgccaaaa    27600

cagtcaaaaa taatctatgt ggaaaaaatc aacaaaggga tcccccgggc tgcaggaatt    27660

cgatggcgcg ccttaattaa aattatctct aaggcatgtg aactggctgt cttggttttc    27720

atctgtactt catctgctac ctctgtgacc tgaaacatat ttataattcc attaagctgt    27780

gcatatgata gatttatcat atgtattttc cttaaaggat ttttgtaaga actaattgaa    27840

ttgatacctg taaagtcttt atcacactac ccaataaata ataaatctct ttgttcagct    27900

ctctgtttct ataaatatgt accagtttta ttgtttttag tggtagtgat tttattctct    27960

ttctatatat atacacacac atgtgtgcat tcataaatat atacaatttt tatgaataaa    28020

aaattattag caatcaatat tgaaaaccac tgatttttgt ttatgtgagc aaacagcaga    28080

ttaaaaggct agcctgcagg agtcaatggg aaaaacccat tggagccaag tacactgact    28140

caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg gtgagtcaac    28200

aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa tgggttttgc    28260

ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact gacatgtata    28320

ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa taggggtgaa    28380

tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt tccattgggt    28440

tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca ttattggcac    28500

atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc tgagtgcccc    28560

tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag gggtgggcaa    28620

ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat gtggtgtact    28680

ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta gtctctgtga    28740

acattcaagc atctgccttc tccctcctgt gagtttggta agtcactgac tgtctatgcc    28800

tgggaaaggg tgggcaggag gtggggcagt gcaggaaaag tggcactgtg aaccctgcag    28860

ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg tgtacagtag    28920

tagcaagctt aaggatctag actgccatgg gcgtgcacga gtgccccgcc tggctgtggc    28980

tgctgctgtc cctgctgtct ctgcccctgg gcctgcctgt gctgggagcc cctccccggc    29040

tgatctgcga cagccgggtg ctggaaagat acctgctgga agccaaagag gccgagaaca    29100

tcaccaccgg ctgcgccgag cactgcagcc tgaacgagaa tatcaccgtg cccgacacca    29160

aggtgaactt ctacgcctgg aagcggatgg aagtgggcca gcaggccgtg gaagtgtggc    29220

agggcctggc cctgctgtcc gaggccgtgc tgagagggca ggccctgctg gtgaacagca    29280

gccagccctg ggagcctctg cagctgcacg tggacaaggc cgtgagcggc ctgcggagcc    29340

tgaccaccct gctgagggcc ctgggcgccc agaaagaggc catcagcccc cctgatgccg    29400

cctctgccgc ccctctgcgg accatcaccg ccgacacctt ccggaagctg ttccgggtgt    29460

acagcaactt cctgcggggc aagctgaagc tgtacaccgg cgaggcctgc cggaccggcg    29520

atcgctgagg atccccatcc agcttggcca gacatgataa gatacattga tgagtttgga    29580

caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt    29640

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat    29700

tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac    29760

aaatgtggta tggaattcag tcaatatgtt caccccaaaa aagctgtttg ttaacttgcc    29820

aacctcattc taaaatgtat atagaagccc aaaagacaat aacaaaaata ttcttgtaga    29880

acaaaatggg aaagaatgtt ccactaaata tcaagattta gagcaaagca tgagatgtgt    29940

ggggatagac agtgaggctg ataaaataga gtagagctca gaaacagacc cattgatata    30000

tgtaagtgac ctatgaaaaa aatatggcat tttacaatgg gaaaatgatg gtctttttct    30060

tttttagaaa aacagggaaa tatatttata tgtaaaaaat aaaagggaac ccatatgtca    30120

taccatacac acaaaaaaat tccagtgaat tataagtcta aatggagaag gcaaaacttt    30180

aaatctttta gaaaataata tagaagcatg ccatcaagac ttcagtgtag agaaaaattt    30240

cttatgactc aaagtcctaa ccacaaagaa aagattgtta attagattgc atgaatatta    30300

agacttattt ttaaaattaa aaaaccatta agaaaagtca ggccatagaa tgacagaaaa    30360

tatttgcaac accccagtaa agagaattgt aatatgcaga ttataaaaag aagtcttaca    30420

aatcagtaaa aaataaaact agacaaaaat ttgaacagat gaaagagaaa ctctaaataa    30480

tcattacaca tgagaaactc aatctcagaa atcagagaac tatcattgca tatacactaa    30540

attagagaaa tattaaaagg ctaagtaaca tctgtggctt aattaaggcg cgcccctagg    30600

ggccggcctt aattaaatca agcttatcga taccgtcgaa cctcgagggg gggcatcact    30660

ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt cacaaactcc    30720

accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga tgatgtttaa    30780

actacggccc ggtacccagc ttttgttccc tttagtgagg gttaatttcg agcttggcgt    30840

aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca    30900

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat    30960

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt    31020

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct    31080

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa    31140

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa    31200

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc    31260

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga    31320

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc    31380

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt    31440

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct    31500

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg    31560

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta    31620

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct    31680

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa    31740

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt    31800

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta    31860

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat    31920

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa    31980

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct    32040

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta    32100

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct    32160

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg    32220

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa    32280

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt    32340

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta    32400

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca    32460

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta    32520

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct    32580

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg    32640

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac    32700

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact    32760

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa    32820

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt    32880

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat    32940

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgcgacgcg    33000

gacgcgcgta atacgactca ctatagggcg aattggagct ccactacgta gtttaaa       33057


<210>  19
<211>  582
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human EPO

<400>  19
atgggggtgc acgaatgtcc tgcctggctg tggcttctcc tgtccctgct gtcgctccct       60

ctgggcctcc cagtcctggg cgccccacca cgcctcatct gtgacagccg agtcctggag      120

aggtacctct tggaggccaa ggaggccgag aatatcacga cgggctgtgc tgaacactgc      180

agcttgaatg agaatatcac tgtcccagac accaaagtta atttctatgc ctggaagagg      240

atggaggtcg ggcagcaggc cgtagaagtc tggcagggcc tggccctgct gtcggaagct      300

gtcctgcggg gccaggccct gttggtcaac tcttcccagc cgtgggagcc cctgcagctg      360

catgtggata aagccgtcag tggccttcgc agcctcacca ctctgcttcg ggctctggga      420

gcccagaagg aagccatctc ccctccagat gcggcctcag ctgctccact ccgaacaatc      480

actgctgaca ctttccgcaa actcttccga gtctactcca atttcctccg gggaaagctg      540

aagctgtaca caggggaggc ctgcaggaca ggggacagat ga                         582


<210>  20
<211>  582
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optimized sequence of human EPO

<400>  20
atgggcgtgc acgagtgccc cgcctggctg tggctgctgc tgtccctgct gtctctgccc       60

ctgggcctgc ctgtgctggg agcccctccc cggctgatct gcgacagccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

agcctgaacg agaatatcac cgtgcccgac accaaggtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc cgtggaagtg tggcagggcc tggccctgct gtccgaggcc      300

gtgctgagag ggcaggccct gctggtgaac agcagccagc cctgggagcc tctgcagctg      360

cacgtggaca aggccgtgag cggcctgcgg agcctgacca ccctgctgag ggccctgggc      420

gcccagaaag aggccatcag cccccctgat gccgcctctg ccgcccctct gcggaccatc      480

accgccgaca ccttccggaa gctgttccgg gtgtacagca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ctgccggacc ggcgatcgct ga                         582


