                         SEQUENCE LISTING

<110>  STALLERGENES
 
<120>  IL-10 AS A PREDICTIVE BIOMARKER OF RESPONSIVENESS TO HOUSE DUST 
       MITE ALLERGEN IMMUNOTHERAPY

<130>  BET 16P3585

<150>  EP16305026.3
<151>  2016-01-13

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  1
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210>  2
<211>  4892
<212>  DNA
<213>  Homo sapiens

<400>  2
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttgtgagt atgattcctt      240

cctgtccttt ctctcttcct gggactgcct gaactagaca ttctcctgga actataagaa      300

ccctcctcct gcgcctccac ctccatcccc aacacctatt cccccaaact taaattctta      360

agagaatcct agatcaagcc atgggtttgg tgagttaagc taagccagat gatacagtaa      420

atgtgcagga aacctgcctt ataaagtaaa tgcgttctct ctcgtgctga gaaacttata      480

agatcctgct ggcgctctat actttattgg ctaggagaag taaagaaatg tctgattcga      540

ggtgaagatg ctccccatgc cttgcagcag ggaaatttaa attgcctctg cttagagcgt      600

ttccagacct gaaagaccag tggtttaggg aagcactcta catgagggaa acctgcatta      660

gaaggagctt cttaatccct gggatctttc caagctaaac tggatgtcta cagtggggag      720

aaagaaaagc agagaacagg acatgagggg ggctcaaggc cccgaagggt tgacataggt      780

gtcccttaaa gccgaatgta gctccgcaga aagaagacca ggactgagtc aagcttctgc      840

tttcccttca aaatcggcca gattttttaa ataacttgac tctgaggagg aggacctgat      900

ttaagtgatg gtcccatcac tgttgaatcc tctgttttta aaactcccct tttgattttt      960

ttgggccaga gccaatttta tttaaaaaaa aaaatctcta aatgaaaggg catcaaaaag     1020

accgcatttc agttatttcc ccaaacctca agttcattct ccttttgttc ttcctgcagc     1080

aaatgaagga tcagctggac aacttgttgt taaaggagtc cttgctggag gactttaagg     1140

tgagagcagg ggcggggtgc tgggggagtg tgcagcatga ttaagggaag ggagactctg     1200

cttcctgatt gcagggaatt gggtttgttt ccttcgcttt gaaaaggaga agtgggaaga     1260

tgttaactca gcacatccag cagccagagg gtttacaaag ggctcagtcc cttcggggag     1320

gcttctggtg aaggaggatc gctagaacca agctgtcctc ttaagctagt tgcagcagcc     1380

cctcctccca gccacctccg ccaatctctc actcaccttt ggctcctgcc cttagggtta     1440

cctgggttgc caagccttgt ctgagatgat ccagttttac ctggaggagg tgatgcccca     1500

agctgagaac caagacccag acatcaaggc gcatgtgaac tccctggggg agaacctgaa     1560

gaccctcagg ctgaggctac ggcgctgtgt aagtagcaga tcagtttttt cccttgcagc     1620

tgcccccaaa ataccatctc ctacagacca gcagggacac tcacatccac agacacagca     1680

aagacacaga ctggcagagc tagctgtaaa tgaggaaaga ctcctggagt cagatctctt     1740

gctcatttct ctttgagcag gcgttggggg tggctgctag gcatttacat gtgaaatttg     1800

caaacagctt tcctgttatt tgtgagtcat ttgtgggtta ttaactactc ccctctctct     1860

tcataaaagg agcccagagc ttcagtcagg cctccactgc ctctttgtaa ctagaccctg     1920

ggcggggagc taaggttccc aagcagagga aacatcattc acctctttta atctcaatgt     1980

tttgaaagca aagctctaag aagggcccaa ttgactgaca ggatttcccc tggcatttta     2040

gaagggacaa gggggctatt catccccagg ctagtgtcta tgagtaattc ctccaggtaa     2100

tttatttctc caactgaaat gatgccctca ctactaatgg tttcccctgt tctgtcacca     2160

atattggaaa atcagttggt gtctatttgt aggacaaggc tatgtgaagg gtttggtccc     2220

agtagcttcc ctcctcagat gcttagaagt gttcctcggt ggctgtgact gacggggagg     2280

aacaggagag agaggcagaa aaggacaggc tgaagaatgc ctcgctcagc actgcaggag     2340

atactgtaga gttctggggg aggaaggaat cccaagacct gggttgtcat ccaagccttg     2400

caaacatctt ggagtgagtc ctggagaaat acatttaact cccagggcca tggaagcagg     2460

gctcagttct ctctgggagc tgtgaggcaa ggcatttgga taaatctggc ctcctcatga     2520

tgccaccagc ttgtccccta agtgtgatgg acatggagct ggaagccagg atcaccaaca     2580

ctttctcttt tcttccacag catcgatttc ttccctgtga aaacaagagc aaggccgtgg     2640

agcaggtgaa gaatgccttt aataaggtga gcttggatgg tggcagagag ggtctgcaga     2700

gcacaaccca tgcccactcc ccaaccccaa agcatggaag gtggtgggga ctcaataggc     2760

cccattcttc attggagaga gtgtgggaac ctgacagatg gtatgacctg ctcagccagt     2820

gaggagctgc tgccttgatt gtatttgttt tctgttaagt gtctttgggg gtttctaaat     2880

gactgctcgc tgcctttgca ggcttgcggg ttaggctggc cggccagcct gtgaacacag     2940

tgagctgcat gctggggaga gtgacaaagg aaacagaaag tacagaaagt agcttgttgg     3000

gaatctaggc tgaacccaca cgtgcaggaa gctggcacat aaatgtgcac atacaaatac     3060

acctgggggt tcagcccaga ctccccagaa ctcagaatga gcaggaagct ggattctcac     3120

ttaacctgga gttggttcaa gcccgctttc catctgccct tcgcacctgc ggaggtgcct     3180

gagaatgtca gttcccaaac gaaatggggt ttcacacttc caactgtgcg tgaacttttt     3240

cagtctgatt tcccagaaac cgtgcggcct atgtcctcct cgtgggctgg ggacagacac     3300

tgcacagagt gccaacatca gggggtgtga atttctcata gtaggtcagg gcggcagggc     3360

agggcctgct cagtgtgttg gtgggagaac acagacattt aaaaggctcc ctcctctcct     3420

ctcaccgtct tgctttcgaa gcgcttcctc taatgtcttt tcatcaaact ctgcataatc     3480

atcatgtgaa tacgtgacct ttaaaattgt tgaaaaggca tcattttgaa gacagtgctt     3540

tgcaaaatga atgctcccct tgctaggggg aggcctggag gagatgaagg tcaatgcaca     3600

gcctttccca aggcagctag gcctatcctc tggtttactt cccagcgtga gggagaacaa     3660

gcaacctctg cactcaaggt catgcccatc catgagcatg agggagggga gcctatttag     3720

tccccagaaa ggattttaac tgtatgtttc ttatctctct gcacagctcc aagagaaagg     3780

catctacaaa gccatgagtg agtttgacat cttcatcaac tacatagaag cctacatgac     3840

aatgaagata cgaaactgag acatcagggt ggcgactcta tagactctag gacataaatt     3900

agaggtctcc aaaatcggat ctggggctct gggatagctg acccagcccc ttgagaaacc     3960

ttattgtacc tctcttatag aatatttatt acctctgata cctcaacccc catttctatt     4020

tatttactga gcttctctgt gaacgattta gaaagaagcc caatattata atttttttca     4080

atatttatta ttttcacctg tttttaagct gtttccatag ggtgacacac tatggtattt     4140

gagtgtttta agataaatta taagttacat aagggaggaa aaaaaatgtt ctttggggag     4200

ccaacagaag cttccattcc aagcctgacc acgctttcta gctgttgagc tgttttccct     4260

gacctccctc taatttatct tgtctctggg cttggggctt cctaactgct acaaatactc     4320

ttaggaagag aaaccaggga gcccctttga tgattaattc accttccagt gtctcggagg     4380

gattccccta acctcattcc ccaaccactt cattcttgaa agctgtggcc agcttgttat     4440

ttataacaac ctaaatttgg ttctaggccg ggcgcggtgg ctcacgcctg taatcccagc     4500

actttgggag gctgaggcgg gtggatcact tgaggtcagg agttcctaac cagcctggtc     4560

aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgggcat ggtggcgcgc     4620

acctgtaatc ccagctactt gggaggctga ggcaagagaa ttgcttgaac ccaggagatg     4680

gaagttgcag tgagctgata tcatgcccct gtactccagc ctgggtgaca gagcaagact     4740

ctgtctcaaa aaataaaaat aaaaataaat ttggttctaa tagaactcag ttttaactag     4800

aatttattca attcctctgg gaatgttaca ttgtttgtct gtcttcatag cagattttaa     4860

ttttgaataa ataaatgtat cttattcaca tc                                   4892


<210>  3
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  3

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  4
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


