                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  MIC-1 RECEPTOR AND USES THEREOF

<130>  160001WO02

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  1
ttattctgga cagttactct taagaaagtt gtcagaagaa acgcatctgc cttttttttc       60

caggtgaact gccgtgagtt gtccagcatg atagtgttta ttttcttggc tatggggtta      120

agcttggaaa atgaatacac ttcccaaacc aataattgca catatttaag agagcaatgc      180

ttacgtgatg caaatggatg taaacatgct tggagagtaa tggaagatgc ctgcaatgat      240

tcagatccag gtgacccctg caagatgagg aattcatcat actgtaacct gagtatccag      300

tacttagtgg aaagcaattt ccaatttaaa gagtgtcttt gcactgatga cttctattgt      360

actgtgaaca aactgcttgg aaaaaaatgt atcaataaat cagataacgt gaaagaggat      420

aaattcaaat ggaatctaac tacacgttcc catcatggat tcaaagggat gtggtcctgt      480

ttggaagtgg cagaggcatg tgtaggggat gtggtctgta atgcacagtt ggcctcttac      540

cttaaagctt gctcagcaaa tggaaatccg tgtgatctga aacagtgcca agcagccata      600

cggttcttct atcaaaatat accttttaac attgcccaga tgttggcttt ttgtgactgt      660

gctcaatctg atataccttg tcagcagtcc aaagaagctc ttcacagcaa gacatgtgca      720

gtgaacatgg ttccaccccc tacttgcctc agtgtaattc gcagctgcca aaatgatgaa      780

ttatgcagga ggcactatag aacatttcag tcaaaatgct ggcagcgtgt gactagaaag      840

tgccatgaag atgagaattg cattagcacc ttaagcaaac aggacctcac ttgttcagga      900

agtgatgact gcaaagctgc ttacatagat atccttggga cggtccttca agtgcaatgt      960

acctgtagga ccattacaca aagtgaggaa tctttgtgta agattttcca gcacatgctt     1020

catagaaaat catgtttcaa ttatccaacc ctgtctaatg tcaaaggcat ggcattgtat     1080

acaagaaaac atgcaaacaa aatcacttta actggatttc attccccctt caatggagaa     1140

gtaatctatg ctgccatgtg catgacagtc acctgtggaa tccttctgtt ggttatggtc     1200

aagcttagaa cttccagaat atcaagtaaa gcaagagatc cttcaccgat ccaaatacct     1260

ggagaactct gattcattag gagtcatgga cctataacaa tcactctttt ctctgctttt     1320

cttctttcct cttttcttct cttctctcct ctcctctctt ctcctctcct cccctcccct     1380

ctctgtttct ttttcttttt cttttctttt ttgtggtgga gttttgctct tgttgcccag     1440

gctgcagtac aatggctcaa tctcggttca ctgcaacctc tgcctccaag gttcaagtga     1500

ttttcctgcc tcagcctccc gagtagctgg gattacaggt acccgccacc acgcccagct     1560

aatttttttg tatttttagt agagatgggg ttttgccaaa ttggccaggg tggtctcaaa     1620

ctcctgacct caggtgatcc acccacctcg gcctcccaaa gtgctgggat tacaggcgtg     1680

agcaaccacg tcaagacaac aatcactttc tttaaagcaa atcctacagc tggtcaacac     1740

actattccat ctgtcatcga gaaagaaaat gttaaaatag acttaaaaat attgctttgt     1800

tacatataat aatatggcat gatgatgtta tttttttctt aatactcaag aaaaatatat     1860

ggtggtatct tttacaacac tggaacagaa ataaagtttc ccttgaaggc                1910


<210>  2
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  TRANSMEM
<222>  (352)..(371)

<400>  2

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  3
<211>  2080
<212>  DNA
<213>  Mus musculus

<400>  3
aacaattgaa tttgaataca attaggaaag ttcacagctc aaaacaaact ggtgaggaac       60

agctgacacc agaagctgac tctaattggc tggctcttag gaagcaaaac ctttacacag      120

aaacttcagt tgggatgttg gttggtgtca gctcatccgc ctttctccca gggagaccat      180

cttgagttgt ccaacatgct agtgttcatt ttcctggctg ttacgttaag ctcagaaaat      240

gaatcctctt cccaaacaaa tgattgtgca catttaatac agaaatgctt gattgatgca      300

aatggctgtg agcagtcatg gagatcaatg gaagacacct gccttactcc aggtgactcc      360

tgcaagataa ataattcact acattgtaac ctgagtatcc aggctttggt ggaaaaaaat      420

ttccaattta aagagtgtct ttgtatggat gacctccact gtacagtaaa caaacttttt      480

ggaaaaaagt gcaccaataa gacagataac atggaaaagg acaataaaga taaatggaat      540

ctaactacta ctcctttcta tcatggattc aaacagatgc agtcttgttt ggaggtgaca      600

gaggcgtgtg taggggatgt ggtttgtaat gcacagttgg ccctttacct taaagcatgc      660

tcagcaaatg gaaatctgtg tgatgtgaaa cactgccaag cagccatacg gttcttctat      720

caaaatatgc cttttaacac tgcccagatg ttggcttttt gtgactgtgc tcaatctgat      780

ataccctgtc agcaatccaa agaaactctt cacagcaagc catgtgcact gaatatagtt      840

ccacccccca cttgcctcag tgtaattcac acttgccgaa atgatgaatt atgcaggaca      900

cactaccgaa cattccagac agaatgctgg ccccacataa ctgggaagtg ccatgaagat      960

gagacctgca ttagcatgtt aggcaagcaa gaccttactt gttctgggag tgagagctgc     1020

agggctgcct tcctaggaac ctttgggaca gtcctgcaag taccctgtgc ttgcaggggc     1080

gttacacagg ctgaagaaca cgtgtgcatg attttccagc acatgcttca tagcaaatcg     1140

tgtttcaatt acccaactcc taatgtcaaa gacatttcct catatgaaaa aaagaattca     1200

aaagaaatta ctctgactgg attcaattct ttcttcaatg gagaactact ctatgttgtt     1260

gtatgcatgg cagttacctg tggaattctt ttcttggtga tgctcaagtt aaggatacaa     1320

agtgaaaaaa gagatccctc atccatcgaa atagctggag gtgtcatcat tcagtgagct     1380

gcagatcact taccaaccac atgtctgtgt gactaaccaa tggaaaatta catttgccaa     1440

taacgcaatt taagatggat ttgacaatat ttagtcatta tatgtaacag tgactggtac     1500

agtaatatac cacaatgatc acagatctgt ttttgttttt gtttttaatg tttgagtaaa     1560

tacttgttgt ggtgtcataa ctagttgata acattttctt taaagacaac aggtgtcatg     1620

taaaatgtga caaatttgct ggaagactat caatccacat atcaacttct atcttatgga     1680

actaatcata attagtgtgt gcagttttct gaacaaggtt atagttttcc attaagttgg     1740

taaaattaaa atgctaagta gaatattgag tatacttgtt atttatatat tcttacttag     1800

tgtccaatca ttaaacaaat tggtaacatt gaacatattt agttagatga ctgcttatga     1860

aaataagaac tgacatctta caaattttat aatttaaata gtattgaatt ttacttttta     1920

tttggtatgt taagattcat aatatataaa gcagctacat tggttgagaa aagtcaatgg     1980

ttactccagt aatgatatac tttgtgaatt tatttatttt tgctaattaa tgatcctgaa     2040

tgtaatcatg atgaaataaa aaagacatac ttaaattgct                           2080


<210>  4
<211>  393
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  VARSPLIC
<222>  (1)..(393)
<223>  membrane protein; alternatively spliced

<220>
<221>  TRANSMEM
<222>  (350)..(370)

<400>  4

Met Leu Val Phe Ile Phe Leu Ala Val Thr Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu 
            20                  25                  30          


Ile Asp Ala Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr 
        35                  40                  45              


Cys Leu Thr Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu 
65                  70                  75                  80  


Cys Leu Cys Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp 
            100                 105                 110         


Lys Trp Asn Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met 
        115                 120                 125             


Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Glu Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu 
                245                 250                 255     


Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Glu Ser Cys Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln 
        275                 280                 285             


Val Pro Cys Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys 
    290                 295                 300                 


Met Ile Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys 
                325                 330                 335     


Glu Ile Thr Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Glu Leu Leu 
            340                 345                 350         


Tyr Val Val Val Cys Met Ala Val Thr Cys Gly Ile Leu Phe Leu Val 
        355                 360                 365             


Met Leu Lys Leu Arg Ile Gln Ser Glu Lys Arg Asp Pro Ser Ser Ile 
    370                 375                 380                 


Glu Ile Ala Gly Gly Val Ile Ile Gln 
385                 390             


<210>  5
<211>  1114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(28)

<220>
<221>  VARSPLIC
<222>  (1)..(1114)
<223>  alternatively spliced

<220>
<221>  TRANSMEM
<222>  (637)..(667)

<400>  5

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  6
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(348)
<223>  hGFRAL extracellular region

<220>
<221>  MISC_FEATURE
<222>  (349)..(358)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (359)..(577)
<223>  mouse Anti-TNP light chain

<400>  6

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
            20                  25                  30          


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
        35                  40                  45              


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
    50                  55                  60                  


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
65                  70                  75                  80  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
            100                 105                 110         


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
        115                 120                 125             


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
    130                 135                 140                 


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
145                 150                 155                 160 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
                165                 170                 175     


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
            180                 185                 190         


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
        195                 200                 205             


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
    210                 215                 220                 


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
225                 230                 235                 240 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
                245                 250                 255     


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
            260                 265                 270         


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
        275                 280                 285             


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
    290                 295                 300                 


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
305                 310                 315                 320 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
                325                 330                 335     


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser 
        355                 360                 365             


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
    370                 375                 380                 


Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
385                 390                 395                 400 


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
                405                 410                 415     


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            420                 425                 430         


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
        435                 440                 445             


Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly 
    450                 455                 460                 


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
465                 470                 475                 480 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
                485                 490                 495     


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
            500                 505                 510         


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
        515                 520                 525             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
    530                 535                 540                 


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
545                 550                 555                 560 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
                565                 570                 575     


Cys 
    


<210>  7
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(340)
<223>  hGFRAL extracellular region

<220>
<221>  MISC_FEATURE
<222>  (341)..(575)
<223>  hIgG1.1_Fc

<400>  7

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
            20                  25                  30          


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
        35                  40                  45              


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
    50                  55                  60                  


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
65                  70                  75                  80  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
            100                 105                 110         


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
        115                 120                 125             


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
    130                 135                 140                 


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
145                 150                 155                 160 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
                165                 170                 175     


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
            180                 185                 190         


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
        195                 200                 205             


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
    210                 215                 220                 


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
225                 230                 235                 240 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
                245                 250                 255     


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
            260                 265                 270         


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
        275                 280                 285             


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
    290                 295                 300                 


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
305                 310                 315                 320 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
                325                 330                 335     


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
465                 470                 475                 480 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570                 575 


<210>  8
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(345)
<223>  mGFRAL extracellular region

<220>
<221>  MISC_FEATURE
<222>  (346)..(355)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (357)..(575)
<223>  mouse Anti-TNP light chain

<400>  8

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu Ile Asp Ala 
            20                  25                  30          


Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr Cys Leu Thr 
        35                  40                  45              


Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys Asn Leu Ser 
    50                  55                  60                  


Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu Cys Leu Cys 
65                  70                  75                  80  


Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly Lys Lys Cys 
                85                  90                  95      


Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp Lys Trp Asn 
            100                 105                 110         


Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met Gln Ser Cys 
        115                 120                 125             


Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
    130                 135                 140                 


Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Leu Cys Asp 
145                 150                 155                 160 


Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Met Pro 
                165                 170                 175     


Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
            180                 185                 190         


Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys Pro Cys Ala 
        195                 200                 205             


Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile His Thr Cys 
    210                 215                 220                 


Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe Gln Thr Glu 
225                 230                 235                 240 


Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu Thr Cys Ile 
                245                 250                 255     


Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser Glu Ser Cys 
            260                 265                 270         


Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln Val Pro Cys 
        275                 280                 285             


Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys Met Ile Phe 
    290                 295                 300                 


Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro Thr Pro Asn 
305                 310                 315                 320 


Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys Glu Ile Thr 
                325                 330                 335     


Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
        355                 360                 365             


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
    370                 375                 380                 


Leu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
385                 390                 395                 400 


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
                405                 410                 415     


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            420                 425                 430         


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
        435                 440                 445             


Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
    450                 455                 460                 


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
465                 470                 475                 480 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
                485                 490                 495     


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
            500                 505                 510         


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
        515                 520                 525             


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
    530                 535                 540                 


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
545                 550                 555                 560 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
                565                 570                 


<210>  9
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(127)
<223>  hGFRAL extracellular C1 domain

<220>
<221>  MISC_FEATURE
<222>  (128)..(137)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (138)..(356)
<223>  mouse Anti-TNP light chain

<400>  9

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
            20                  25                  30          


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
        35                  40                  45              


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
    50                  55                  60                  


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
65                  70                  75                  80  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
            100                 105                 110         


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
            180                 185                 190         


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr 
                245                 250                 255     


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
            260                 265                 270         


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
        275                 280                 285             


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
    290                 295                 300                 


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr 
305                 310                 315                 320 


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
                325                 330                 335     


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
            340                 345                 350         


Arg Asn Glu Cys 
        355     


<210>  10
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(105)
<223>  hGFRAL extracellular C2 domain

<220>
<221>  MISC_FEATURE
<222>  (106)..(115)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (116)..(334)
<223>  mouse Anti-TNP light chain

<400>  10

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
            20                  25                  30          


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
        35                  40                  45              


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
    50                  55                  60                  


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
65                  70                  75                  80  


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
                85                  90                  95      


Ala Val Asn Met Val Pro Pro Pro Thr Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
        115                 120                 125             


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
    130                 135                 140                 


Leu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
                165                 170                 175     


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            180                 185                 190         


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
        195                 200                 205             


Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
225                 230                 235                 240 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
                245                 250                 255     


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
            260                 265                 270         


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
        275                 280                 285             


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
    290                 295                 300                 


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
305                 310                 315                 320 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
                325                 330                 


<210>  11
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(148)
<223>  hGFRAL extracellular C3 domain

<220>
<221>  MISC_FEATURE
<222>  (149)..(158)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (159)..(377)
<223>  mouse Anti-TNP light chain

<400>  11

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Cys Leu Ser Val Ile Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg 
            20                  25                  30          


His Tyr Arg Thr Phe Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys 
        35                  40                  45              


Cys His Glu Asp Glu Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu 
    50                  55                  60                  


Thr Cys Ser Gly Ser Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu 
65                  70                  75                  80  


Gly Thr Val Leu Gln Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser 
                85                  90                  95      


Glu Glu Ser Leu Cys Lys Ile Phe Gln His Met Leu His Arg Lys Ser 
            100                 105                 110         


Cys Phe Asn Tyr Pro Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr 
        115                 120                 125             


Thr Arg Lys His Ala Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro 
    130                 135                 140                 


Phe Asn Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly 
            180                 185                 190         


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
225                 230                 235                 240 


Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His 
                245                 250                 255     


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            260                 265                 270         


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
        275                 280                 285             


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
    290                 295                 300                 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
305                 310                 315                 320 


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
                325                 330                 335     


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
            340                 345                 350         


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
        355                 360                 365             


Val Lys Ser Phe Asn Arg Asn Glu Cys 
    370                 375         


<210>  12
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(216)
<223>  hGFRAL extracellular C1 and C2 domains

<220>
<221>  MISC_FEATURE
<222>  (217)..(226)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (227)..(445)
<223>  mouse Anti-TNP light chain

<400>  12

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
            20                  25                  30          


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
        35                  40                  45              


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
    50                  55                  60                  


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
65                  70                  75                  80  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
            100                 105                 110         


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
        115                 120                 125             


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
    130                 135                 140                 


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
145                 150                 155                 160 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
                165                 170                 175     


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
            180                 185                 190         


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
        195                 200                 205             


Val Asn Met Val Pro Pro Pro Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
225                 230                 235                 240 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                245                 250                 255     


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
            260                 265                 270         


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
        275                 280                 285             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
305                 310                 315                 320 


Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                325                 330                 335     


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
            340                 345                 350         


Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
        355                 360                 365             


Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
    370                 375                 380                 


Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
385                 390                 395                 400 


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
                405                 410                 415     


Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
            420                 425                 430         


Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
        435                 440                 445 


<210>  13
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CD33 Signal sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(237)
<223>  hGFRAL extracellular C2 and C3 domains

<220>
<221>  MISC_FEATURE
<222>  (238)..(247)
<223>  GGGGSGGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (248)..(466)
<223>  mouse Anti-TNP light chain

<400>  13

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
            20                  25                  30          


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
        35                  40                  45              


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
    50                  55                  60                  


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
65                  70                  75                  80  


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
                85                  90                  95      


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
            100                 105                 110         


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
        115                 120                 125             


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
    130                 135                 140                 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
145                 150                 155                 160 


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
                165                 170                 175     


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
            180                 185                 190         


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
        195                 200                 205             


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
    210                 215                 220                 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu 
                245                 250                 255     


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
            260                 265                 270         


Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
        275                 280                 285             


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
    290                 295                 300                 


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
                325                 330                 335     


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
        355                 360                 365             


Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val 
    370                 375                 380                 


Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp 
385                 390                 395                 400 


Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr 
                405                 410                 415     


Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr 
            420                 425                 430         


Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala 
        435                 440                 445             


Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn 
    450                 455                 460                 


Glu Cys 
465     


<210>  14
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  signal sequence of mouse Ig heavy chain

<220>
<221>  MISC_FEATURE
<222>  (19)..(236)
<223>  mouse Anti-TNP fab heavy chain

<220>
<221>  MISC_FEATURE
<222>  (237)..(285)
<223>  human PDGFRB gene region containing the TM

<220>
<221>  MISC_FEATURE
<222>  (257)..(277)
<223>  human PDGFRB Transmembrane

<400>  14

Met Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Leu Pro Gly Ile 
1               5                   10                  15      


Leu Ser Glu Val Gln Ile Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly His Lys Ile Glu 
    50                  55                  60                  


Tyr Met Gly Thr Ile Ser Tyr Ser Gly Asp Thr Tyr Tyr Asn Pro Ser 
65                  70                  75                  80  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr 
                85                  90                  95      


Tyr Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Tyr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Ala Val Gly Gln 
225                 230                 235                 240 


Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val 
                245                 250                 255     


Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser 
            260                 265                 270         


Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
        275                 280                 285 


<210>  15
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  signal sequence of mouse Ig heavy chain

<220>
<221>  MISC_FEATURE
<222>  (19)..(236)
<223>  mouse Anti-TNP fab heavy chain

<220>
<221>  MISC_FEATURE
<222>  (237)..(241)
<223>  GGGGS linker

<220>
<221>  MISC_FEATURE
<222>  (242)..(253)
<223>  HPC4 tag

<400>  15

Met Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Leu Pro Gly Ile 
1               5                   10                  15      


Leu Ser Glu Val Gln Ile Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly His Lys Ile Glu 
    50                  55                  60                  


Tyr Met Gly Thr Ile Ser Tyr Ser Gly Asp Thr Tyr Tyr Asn Pro Ser 
65                  70                  75                  80  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr 
                85                  90                  95      


Tyr Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Tyr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
                245                 250             


<210>  16
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (7)..(14)

<220>
<221>  DISULFID
<222>  (15)..(78)

<220>
<221>  DISULFID
<222>  (44)..(109)

<220>
<221>  DISULFID
<222>  (48)..(111)

<220>
<221>  DISULFID
<222>  (77)..(77)

<400>  16

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  17
<211>  1105
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Asp Ala Gln  His Ser Ser 
    1055                 1060                 1065             


Ser Leu  Val Gly Ala Ala Phe  Gly Lys Ser Gln Gln  Leu Phe Trp 
    1070                 1075                 1080             


Leu Cys  Cys Gln His Cys Asn  Phe Ala Glu Lys Ser  Arg Ile Thr 
    1085                 1090                 1095             


Lys Leu  Pro Ala Leu Gln Thr  
    1100                 1105 


<210>  18
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  19
<211>  1115
<212>  PRT
<213>  Mus musculus

<400>  19

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Gly Leu Lys Leu Ile 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Glu Ala Pro Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Val Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asp Trp Ile Arg Ile Asn Glu Thr Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg 
            100                 105                 110         


Asn Gly Gly Phe Pro Leu Leu Thr Ile Phe Leu Gln Val Phe Leu Gly 
        115                 120                 125             


Ser Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Thr Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe 
145                 150                 155                 160 


Lys Ala Gln Asp Leu Cys Ile Pro Glu Thr Ala Val Ser Phe Arg Val 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe Tyr His Phe His Met Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Ser Leu Leu Gly 
        195                 200                 205             


Gly Asp Ser Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Leu Arg Glu Lys Tyr Val Leu Glu 
225                 230                 235                 240 


Ala Leu Cys Ile Val Ala Gly Pro Gly Ala Asn Lys Glu Thr Val Thr 
                245                 250                 255     


Leu Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr 
            260                 265                 270         


Phe Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg 
        275                 280                 285             


Lys Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val 
    290                 295                 300                 


Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Asn Thr Leu Leu 
305                 310                 315                 320 


Ser Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Ser Pro 
                325                 330                 335     


Ile Glu Thr Leu Val Gln Val Asn Asn Asn Ser Val Arg Ala Thr Met 
            340                 345                 350         


His Asn Tyr Lys Leu Ile Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser 
        355                 360                 365             


Arg Val Leu Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly 
    370                 375                 380                 


Pro Gly Ala Gly Gly Ile Leu Val Leu His Phe Asn Val Ser Val Leu 
385                 390                 395                 400 


Pro Val Thr Leu Asn Leu Pro Arg Ala Tyr Ser Phe Pro Val Asn Lys 
                405                 410                 415     


Arg Ala Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys 
            420                 425                 430         


Gln Glu Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser 
        435                 440                 445             


Ile Asn Cys Thr Ala Leu Gly Val Val Thr Ser Pro Glu Asp Thr Ser 
    450                 455                 460                 


Gly Thr Leu Phe Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys 
465                 470                 475                 480 


Thr Lys Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg 
                485                 490                 495     


Gln Thr Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Ser Ile Thr 
            500                 505                 510         


Glu Glu Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro 
        515                 520                 525             


Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu 
    530                 535                 540                 


Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys 
545                 550                 555                 560 


Ser Pro Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Val Glu 
                565                 570                 575     


Ser Arg Asp Ala Asn Ile Cys Pro Gln Asp Cys Leu Arg Ala Asp Ile 
            580                 585                 590         


Val Gly Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr 
        595                 600                 605             


Gly Ile Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro 
    610                 615                 620                 


Glu Asp Ser Gln Gly Pro Leu Cys Asp Ala Leu Cys Arg Thr Ile Ile 
625                 630                 635                 640 


Thr Ala Ala Leu Phe Ser Leu Ile Ile Ser Ile Leu Leu Ser Ile Phe 
                645                 650                 655     


Cys Val Cys His His His Lys His Gly His Lys Pro Pro Ile Ala Ser 
            660                 665                 670         


Ala Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr 
        675                 680                 685             


Ser Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Thr Glu Asn Gln 
    690                 695                 700                 


Val Pro Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe 
705                 710                 715                 720 


Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
                725                 730                 735     


Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly 
            740                 745                 750         


Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser 
        755                 760                 765             


Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn 
    770                 775                 780                 


His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro 
785                 790                 795                 800 


Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe 
                805                 810                 815     


Leu Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Gly Gly Gly 
            820                 825                 830         


Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr 
        835                 840                 845             


Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln 
    850                 855                 860                 


Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn 
865                 870                 875                 880 


Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu 
                885                 890                 895     


Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly 
            900                 905                 910         


Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile 
        915                 920                 925             


Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
    930                 935                 940                 


Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg 
945                 950                 955                 960 


Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn 
                965                 970                 975     


Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu 
            980                 985                 990         


Pro Asp Lys Arg Pro Val Phe Ala  Asp Ile Ser Lys Asp  Leu Glu Lys 
        995                 1000                 1005             


Met Met  Val Lys Ser Arg Asp  Tyr Leu Asp Leu Ala  Ala Ser Thr 
    1010                 1015                 1020             


Pro Ser  Asp Ser Leu Leu Tyr  Asp Asp Gly Leu Ser  Glu Glu Glu 
    1025                 1030                 1035             


Thr Pro  Leu Val Asp Cys Asn  Asn Ala Pro Leu Pro  Arg Ser Leu 
    1040                 1045                 1050             


Pro Ser  Thr Trp Ile Glu Asn  Lys Leu Tyr Gly Met  Ser Asp Pro 
    1055                 1060                 1065             


Asn Trp  Pro Gly Glu Ser Pro  Val Pro Leu Thr Arg  Ala Asp Gly 
    1070                 1075                 1080             


Thr Ser  Thr Gly Phe Pro Arg  Tyr Ala Asn Asp Ser  Val Tyr Ala 
    1085                 1090                 1095             


Asn Trp  Met Val Ser Pro Ser  Ala Ala Lys Leu Met  Asp Thr Phe 
    1100                 1105                 1110             


Asp Ser  
    1115 


<210>  20
<211>  394
<212>  PRT
<213>  Macaca fascicularis

<400>  20

Met Ile Val Leu Ile Phe Leu Ala Leu Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


His Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Leu Ser Gln Val Pro Gly Glu Leu 
385                 390                 


<210>  21
<211>  1117
<212>  PRT
<213>  Macaca fascicularis

<400>  21

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu 
            20                  25                  30          


Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Pro 
        35                  40                  45              


Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu 
    50                  55                  60                  


Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg 
65                  70                  75                  80  


Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly 
                85                  90                  95      


Leu Leu Tyr Leu Asn Arg Ser Leu Asp Arg Ser Ser Trp Glu Lys Leu 
            100                 105                 110         


Ser Gly Arg Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val 
        115                 120                 125             


Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly 
    130                 135                 140                 


Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys 
145                 150                 155                 160 


Thr Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser 
                165                 170                 175     


Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg 
            180                 185                 190         


Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg 
        195                 200                 205             


Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu 
    210                 215                 220                 


Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr 
225                 230                 235                 240 


Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val 
                245                 250                 255     


Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala 
            260                 265                 270         


Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe 
        275                 280                 285             


Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala 
    290                 295                 300                 


Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr 
305                 310                 315                 320 


Leu Leu Pro Gly Asp Thr Trp Thr Gln Gln Thr Phe Arg Val Glu His 
                325                 330                 335     


Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala 
            340                 345                 350         


Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser 
        355                 360                 365             


Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe 
    370                 375                 380                 


Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val 
385                 390                 395                 400 


Leu Pro Val Ser Leu His Leu Pro Ser Ser Tyr Ser Leu Ser Val Ser 
                405                 410                 415     


Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn 
            420                 425                 430         


Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Glu Leu His Ser Ser 
        435                 440                 445             


Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr 
    450                 455                 460                 


Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys 
465                 470                 475                 480 


Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asn His Gln Thr Ser 
                485                 490                 495     


Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Leu Tyr Val 
            500                 505                 510         


Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg 
        515                 520                 525             


Pro Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys 
    530                 535                 540                 


Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr 
545                 550                 555                 560 


Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val 
                565                 570                 575     


Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser 
            580                 585                 590         


Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly 
        595                 600                 605             


Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu 
    610                 615                 620                 


Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val 
625                 630                 635                 640 


Ile Ala Ala Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser 
                645                 650                 655     


Ala Phe Cys Ile His Arg Tyr His Lys Phe Ala His Lys Pro Pro Ile 
            660                 665                 670         


Pro Ser Ala Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val 
        675                 680                 685             


Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu 
    690                 695                 700                 


Asn Gln Val Ser Val Asp Ala Phe Lys Ile Pro Glu Asp Pro Lys Trp 
705                 710                 715                 720 


Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly 
                725                 730                 735     


Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg 
            740                 745                 750         


Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser 
        755                 760                 765             


Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln 
    770                 775                 780                 


Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp 
785                 790                 795                 800 


Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg 
                805                 810                 815     


Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser 
            820                 825                 830         


Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala 
        835                 840                 845             


Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly 
    850                 855                 860                 


Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala 
865                 870                 875                 880 


Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe 
                885                 890                 895     


Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser 
            900                 905                 910         


Lys Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp 
        915                 920                 925             


His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
    930                 935                 940                 


Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro 
945                 950                 955                 960 


Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro 
                965                 970                 975     


Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys 
            980                 985                 990         


Gln Glu Pro Asp Lys Arg Pro Val  Phe Ala Asp Ile Ser  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Met Met Val Lys Ser  Arg Asp Tyr Leu Asp  Leu Ala Ala 
    1010                 1015                 1020             


Ser Thr  Pro Ser Asp Ser Leu  Leu Tyr Asp Asp Gly  Leu Ser Glu 
    1025                 1030                 1035             


Glu Glu  Thr Pro Leu Val Asp  Cys Asn Asn Ala Pro  Leu Pro Arg 
    1040                 1045                 1050             


Ala Leu  Pro Ser Thr Trp Ile  Glu Asn Lys Leu Tyr  Gly Met Ser 
    1055                 1060                 1065             


Asp Pro  Asn Trp Pro Gly Glu  Ser Pro Val Pro Leu  Thr Arg Ala 
    1070                 1075                 1080             


Asp Gly  Thr Asn Thr Gly Phe  Pro Arg Tyr Ala Asn  Asp Ser Val 
    1085                 1090                 1095             


Tyr Ala  Asn Trp Met Leu Ser  Pro Ser Ala Ala Lys  Leu Met Asp 
    1100                 1105                 1110             


Thr Phe  Asp Ser 
    1115         


<210>  22
<211>  394
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Leu Val Phe Ile Phe Leu Ala Val Arg Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala Tyr Phe Met Arg Gln Cys Leu 
            20                  25                  30          


Thr Asp Thr Asp Gly Cys Lys Gln Ser Trp Arg Ser Met Glu Asp Ala 
        35                  40                  45              


Cys Leu Val Ser Gly Asp Ser Cys Lys Ile Asn Asn Pro Leu Pro Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ser Leu Val Glu Lys His Phe Gln Phe Lys Gly 
65                  70                  75                  80  


Cys Leu Cys Thr Asp Asp Leu His Cys Thr Val Asn Lys Ile Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Ser Met Lys Lys Asp Asn Lys Tyr 
            100                 105                 110         


Lys Arg Asn Leu Thr Thr Pro Leu Tyr His Asp Thr Gly Phe Lys Gln 
        115                 120                 125             


Met Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Thr Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Val Val Pro Pro Pro Thr Cys Leu Ser Val 
    210                 215                 220                 


Ile His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr Tyr Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Thr Glu Cys Trp Pro His Val Ala Gly Lys Cys Arg Glu Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Ser Cys Arg Ala Ala Tyr Leu Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Pro Cys Ala Cys Arg Ser Ile Thr Gln Gly Glu Glu Pro Leu 
    290                 295                 300                 


Cys Met Ala Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Arg Lys His Ser 
                325                 330                 335     


Lys Glu Ile Thr Leu Thr Gly Phe Asn Ser Pro Phe Ser Gly Glu Leu 
            340                 345                 350         


Ile Tyr Val Val Val Cys Met Val Val Thr Ser Gly Ile Leu Ser Leu 
        355                 360                 365             


Val Met Leu Lys Leu Arg Ile Pro Ser Lys Lys Arg Asp Pro Ala Pro 
    370                 375                 380                 


Ile Glu Ile Ala Gly Ala Val Ile Ile Gln 
385                 390                 


<210>  23
<211>  1115
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Met Ala Lys Ala Arg Ser Gly Ala Ala Gly Leu Gly Leu Lys Leu Phe 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Glu Ala Pro Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln Tyr Leu Tyr Gly Val Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asp Trp Ile His Ile Asp Ser Gly Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg 
            100                 105                 110         


Asn Gly Gly Phe Pro Leu Leu Thr Val Phe Leu Gln Val Phe Leu Gly 
        115                 120                 125             


Ser Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe 
145                 150                 155                 160 


Lys Ala Arg Asp Leu Cys Thr Pro Glu Thr Gly Val Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe Tyr Gln Phe Arg Met Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Lys Leu Leu Glu 
        195                 200                 205             


Gly Asp Gly Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Leu Gln Glu Lys Tyr Val Leu Glu 
225                 230                 235                 240 


Ala Glu Cys Ala Val Ala Gly Pro Gly Ala Asn Lys Glu Lys Val Ala 
                245                 250                 255     


Val Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Pro Pro Thr 
            260                 265                 270         


Phe Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg 
        275                 280                 285             


Lys Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val 
    290                 295                 300                 


Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu 
305                 310                 315                 320 


Ser Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Thr Pro 
                325                 330                 335     


Asn Glu Thr Leu Val Gln Ser Asn Asn Asn Ser Val Arg Ala Thr Met 
            340                 345                 350         


His Asn Tyr Lys Leu Val Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser 
        355                 360                 365             


Arg Val Leu Gln Leu Val Val Leu Val Asn Asp Ser Asp Phe Gln Gly 
    370                 375                 380                 


Pro Gly Ser Gly Val Leu Phe Leu His Phe Asn Val Ser Val Leu Pro 
385                 390                 395                 400 


Val Thr Leu Asn Leu Pro Met Ala Tyr Ser Phe Pro Val Asn Arg Arg 
                405                 410                 415     


Ala Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln 
            420                 425                 430         


Glu Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser Thr 
        435                 440                 445             


Asn Cys Ser Ala Leu Gly Val Val Thr Ser Thr Glu Asp Thr Ser Gly 
    450                 455                 460                 


Thr Leu Tyr Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys Thr 
465                 470                 475                 480 


Glu Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg Gln 
                485                 490                 495     


Thr Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Tyr Ile Ala Glu 
            500                 505                 510         


Glu Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro Glu 
        515                 520                 525             


Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp 
    530                 535                 540                 


Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser 
545                 550                 555                 560 


Pro Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Leu Glu Ser 
                565                 570                 575     


Arg Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Pro Ile Val 
            580                 585                 590         


Gly Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr Gly 
        595                 600                 605             


Ile Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro Glu 
    610                 615                 620                 


Asp Ser Gln Gly Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Thr 
625                 630                 635                 640 


Ala Ala Val Leu Phe Ser Phe Ile Ile Ser Val Leu Leu Ser Thr Phe 
                645                 650                 655     


Cys Ile His Arg Tyr His Lys His Ala His Lys Pro Pro Ile Ala Ser 
            660                 665                 670         


Ala Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr 
        675                 680                 685             


Ser Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln 
    690                 695                 700                 


Val Ser Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe 
705                 710                 715                 720 


Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
                725                 730                 735     


Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly 
            740                 745                 750         


Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser 
        755                 760                 765             


Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn 
    770                 775                 780                 


His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro 
785                 790                 795                 800 


Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe 
                805                 810                 815     


Leu Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Ser Gly Gly 
            820                 825                 830         


Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr 
        835                 840                 845             


Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln 
    850                 855                 860                 


Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn 
865                 870                 875                 880 


Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu 
                885                 890                 895     


Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly 
            900                 905                 910         


Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile 
        915                 920                 925             


Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
    930                 935                 940                 


Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg 
945                 950                 955                 960 


Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn 
                965                 970                 975     


Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu 
            980                 985                 990         


Pro Asp Lys Arg Pro Val Phe Ala  Asp Ile Ser Lys Asp  Leu Glu Lys 
        995                 1000                 1005             


Met Met  Val Lys Ser Arg Asp  Tyr Leu Asp Leu Ala  Ala Ser Thr 
    1010                 1015                 1020             


Pro Ser  Asp Ser Leu Leu Tyr  Asp Asp Gly Leu Ser  Glu Glu Glu 
    1025                 1030                 1035             


Thr Pro  Leu Val Asp Cys Asn  Ser Ala Pro Leu Pro  Arg Ser Leu 
    1040                 1045                 1050             


Pro Ser  Thr Trp Ile Glu Asn  Lys Leu Tyr Gly Met  Ser Asp Pro 
    1055                 1060                 1065             


Asn Trp  Pro Gly Glu Ser Pro  Val Pro Leu Thr Arg  Ala Asp Gly 
    1070                 1075                 1080             


Thr Ser  Thr Gly Phe Pro Arg  Tyr Ala Asn Asp Ser  Val Tyr Ala 
    1085                 1090                 1095             


Asn Trp  Met Val Ser Pro Ser  Ala Ala Lys Leu Met  Asp Thr Phe 
    1100                 1105                 1110             


Asp Ser  
    1115 


