                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen GmbH
       Protzer, Ulrike
       Bauer, Tanja
       Kosinska, Anna
       Mck-Husl, Martin
 
<120>  Means and methods for treating HBV

<130>  HEL15387PCT

<150>  LU 92942
<151>  2016-01-12

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV genotype C large envelope protein consensus sequence

<400>  1

Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
        35                  40                  45              


Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His 
        115                 120                 125             


Gln Ala Leu Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly 
    130                 135                 140                 


Gly Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro 
145                 150                 155                 160 


Ile Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu 
                165                 170                 175     


Asn Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly 
            180                 185                 190         


Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser 
        195                 200                 205             


Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr Cys Pro Gly 
    210                 215                 220                 


Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro 
225                 230                 235                 240 


Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 
                245                 250                 255     


Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 
            260                 265                 270         


Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr Ser 
        275                 280                 285             


Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Ile Pro Ala Gln Gly 
    290                 295                 300                 


Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn 
305                 310                 315                 320 


Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe Leu 
                325                 330                 335     


Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro 
            340                 345                 350         


Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
        355                 360                 365             


Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser 
    370                 375                 380                 


Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
385                 390                 395                 400 


<210>  2
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV genotype C core protein consensus sequence

<400>  2

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser 
                165                 170                 175     


Gln Ser Arg Glu Ser Gln Cys 
            180             


<210>  3
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV RT domain of polymerase consensus sequence

<400>  3

Glu Asp Trp Gly Pro Cys Thr Glu His Gly Glu His His Ile Arg Ile 
1               5                   10                  15      


Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 
            20                  25                  30          


Asn Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser Gln 
        35                  40                  45              


Phe Ser Arg Gly Asn Thr Arg Val Ser Trp Pro Lys Phe Ala Val Pro 
    50                  55                  60                  


Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 
65                  70                  75                  80  


Ser Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala 
                85                  90                  95      


Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val 
            100                 105                 110         


Ala Arg Leu Ser Ser Asn Ser Arg Ile Ile Asn His Gln His Gly Thr 
        115                 120                 125             


Met Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu 
    130                 135                 140                 


Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His 
145                 150                 155                 160 


Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser 
                165                 170                 175     


Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg 
            180                 185                 190         


Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 
        195                 200                 205             


Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Tyr Thr Ala Val 
    210                 215                 220                 


Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr 
225                 230                 235                 240 


Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser 
                245                 250                 255     


Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile Lys Gln Cys 
            260                 265                 270         


Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln 
        275                 280                 285             


Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly 
    290                 295                 300                 


Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ala Lys Gln Ala 
305                 310                 315                 320 


Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu 
                325                 330                 335     


Asn Leu Tyr Pro Val Ala Arg 
            340             


<210>  4
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV large envelope protein

<400>  4

Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
        35                  40                  45              


Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His 
        115                 120                 125             


Gln Ala Leu Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly 
    130                 135                 140                 


Gly Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro 
145                 150                 155                 160 


Ile Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu 
                165                 170                 175     


Asn Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly 
            180                 185                 190         


Phe Leu Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser 
        195                 200                 205             


Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr Cys Pro Gly 
    210                 215                 220                 


Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro 
225                 230                 235                 240 


Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 
                245                 250                 255     


Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 
            260                 265                 270         


Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr Ser 
        275                 280                 285             


Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Thr Ile Pro Ala Gln Gly 
    290                 295                 300                 


Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn 
305                 310                 315                 320 


Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Phe Leu 
                325                 330                 335     


Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro 
            340                 345                 350         


Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
        355                 360                 365             


Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser 
    370                 375                 380                 


Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
385                 390                 395                 400 


<210>  5
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core protein

<400>  5

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser 
                165                 170                 175     


Gln Ser Arg Glu Ser Gln Cys 
            180             


<210>  6
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV RT domain of polymerase

<400>  6

Glu Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile Arg Ile 
1               5                   10                  15      


Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 
            20                  25                  30          


Asn Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser Gln 
        35                  40                  45              


Phe Ser Arg Gly Lys Thr Arg Val Ser Trp Pro Lys Phe Ala Val Pro 
    50                  55                  60                  


Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 
65                  70                  75                  80  


Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro Leu His Pro Ala 
                85                  90                  95      


Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val 
            100                 105                 110         


Ala Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn His Gln His Gly Asn 
        115                 120                 125             


Leu Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu 
    130                 135                 140                 


Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His 
145                 150                 155                 160 


Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser 
                165                 170                 175     


Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg 
            180                 185                 190         


Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 
        195                 200                 205             


Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala Val 
    210                 215                 220                 


Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr 
225                 230                 235                 240 


Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser 
                245                 250                 255     


Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile Lys Gln Cys 
            260                 265                 270         


Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln 
        275                 280                 285             


Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly 
    290                 295                 300                 


Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala 
305                 310                 315                 320 


Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu 
                325                 330                 335     


Asn Leu Tyr Pro Val Ala Arg Gln 
            340                 


<210>  7
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion polypeptide

<400>  7

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
225                 230                 235                 240 


Asp Val Glu Glu Asn Pro Gly Pro Met Asp Ile Asp Pro Tyr Lys Glu 
                245                 250                 255     


Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 
            260                 265                 270         


Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu 
        275                 280                 285             


Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg 
    290                 295                 300                 


Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val 
305                 310                 315                 320 


Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Tyr 
                325                 330                 335     


Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp Phe His 
            340                 345                 350         


Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr Leu Val 
        355                 360                 365             


Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 
    370                 375                 380                 


Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Ser Gly 
385                 390                 395                 400 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                405                 410                 415     


Pro Gly Pro Glu Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His 
            420                 425                 430         


Ile Arg Ile Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu 
        435                 440                 445             


Val Asp Lys Asn Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp 
    450                 455                 460                 


Phe Ser Gln Phe Ser Arg Gly Lys Thr Arg Val Ser Trp Pro Lys Phe 
465                 470                 475                 480 


Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 
                485                 490                 495     


Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro Leu 
            500                 505                 510         


His Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser 
        515                 520                 525             


Arg Tyr Val Ala Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn His Gln 
    530                 535                 540                 


His Gly Asn Leu Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr 
545                 550                 555                 560 


Val Ser Leu Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu 
                565                 570                 575     


Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val 
            580                 585                 590         


Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser 
        595                 600                 605             


Val Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp 
    610                 615                 620                 


Asp Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe 
625                 630                 635                 640 


Thr Ala Val Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro 
                645                 650                 655     


Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val 
            660                 665                 670         


Ile Gly Ser Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile 
        675                 680                 685             


Lys Gln Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 
    690                 695                 700                 


Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr 
705                 710                 715                 720 


Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser 
                725                 730                 735     


Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys 
            740                 745                 750         


Gln Tyr Leu Asn Leu Tyr Pro Val Ala Arg Gln Gly Ser Gly Glu Gly 
        755                 760                 765             


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
    770                 775                 780                 


Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu 
785                 790                 795                 800 


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
                805                 810                 815     


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
            820                 825                 830         


Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe Gly 
        835                 840                 845             


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
    850                 855                 860                 


Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser 
865                 870                 875                 880 


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu 
                885                 890                 895     


Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His 
            900                 905                 910         


Gln Ala Leu Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly 
        915                 920                 925             


Gly Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro 
    930                 935                 940                 


Ile Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu 
945                 950                 955                 960 


Asn Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly 
                965                 970                 975     


Phe Leu Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser 
            980                 985                 990         


Trp Trp Thr Ser Leu Asn Phe Leu  Gly Gly Ala Pro Thr  Cys Pro Gly 
        995                 1000                 1005             


Gln Asn  Ser Gln Ser Pro Thr  Ser Asn His Ser Pro  Thr Ser Cys 
    1010                 1015                 1020             


Pro Pro  Ile Cys Pro Gly Tyr  Arg Trp Met Cys Leu  Arg Arg Phe 
    1025                 1030                 1035             


Ile Ile  Phe Leu Phe Ile Leu  Leu Leu Cys Leu Ile  Phe Leu Leu 
    1040                 1045                 1050             


Val Leu  Leu Asp Tyr Gln Gly  Met Leu Pro Val Cys  Pro Leu Leu 
    1055                 1060                 1065             


Pro Gly  Thr Ser Thr Thr Ser  Thr Gly Pro Cys Arg  Thr Cys Thr 
    1070                 1075                 1080             


Ile Pro  Ala Gln Gly Thr Ser  Met Phe Pro Ser Cys  Cys Cys Thr 
    1085                 1090                 1095             


Lys Pro  Ser Asp Gly Asn Cys  Thr Cys Ile Pro Ile  Pro Ser Ser 
    1100                 1105                 1110             


Trp Ala  Phe Ala Lys Phe Leu  Trp Glu Trp Ala Ser  Val Arg Phe 
    1115                 1120                 1125             


Ser Trp  Leu Ser Leu Leu Val  Pro Phe Val Gln Trp  Phe Val Gly 
    1130                 1135                 1140             


Leu Ser  Pro Thr Val Trp Leu  Ser Val Ile Trp Met  Met Trp Tyr 
    1145                 1150                 1155             


Trp Gly  Pro Ser Leu Tyr Asn  Ile Leu Ser Pro Phe  Leu Pro Leu 
    1160                 1165                 1170             


Leu Pro  Ile Phe Phe Cys Leu  Trp Val Tyr Ile Gly  Ser Gly Glu 
    1175                 1180                 1185             


Gly Arg  Gly Ser Leu Leu Thr  Cys Gly Asp Val Glu  Glu Asn Pro 
    1190                 1195                 1200             


Gly Pro  Met Asp Ile Asp Pro  Tyr Lys Glu Phe Gly  Ala Ser Val 
    1205                 1210                 1215             


Glu Leu  Leu Ser Phe Leu Pro  Ser Asp Phe Phe Pro  Ser Ile Arg 
    1220                 1225                 1230             


Asp Leu  Leu Asp Thr Ala Ser  Ala Leu Tyr Arg Glu  Ala Leu Glu 
    1235                 1240                 1245             


Ser Pro  Glu His Cys Ser Pro  His His Thr Ala Leu  Arg Gln Ala 
    1250                 1255                 1260             


Ile Leu  Cys Trp Gly Glu Leu  Met Asn Leu Ala Thr  Trp Val Gly 
    1265                 1270                 1275             


Ser Asn  Leu Glu Asp Pro Ala  Ser Arg Glu Leu Val  Val Ser Tyr 
    1280                 1285                 1290             


Val Asn  Val Asn Met Gly Leu  Lys Ile Arg Gln Leu  Leu Trp Phe 
    1295                 1300                 1305             


His Ile  Ser Cys Leu Thr Phe  Gly Arg Glu Thr Val  Leu Glu Tyr 
    1310                 1315                 1320             


Leu Val  Ser Phe Gly Val Trp  Ile Arg Thr Pro Pro  Ala Tyr Arg 
    1325                 1330                 1335             


Pro Pro  Asn Ala Pro Ile Leu  Ser Thr Leu Pro Glu  Thr Thr Val 
    1340                 1345                 1350             


Val Arg  Arg Arg Gly Arg Ser  Pro Arg Arg Arg Thr  Pro Ser Pro 
    1355                 1360                 1365             


Arg Arg  Arg Arg Ser Gln Ser  Pro Arg Arg Arg Arg  Ser Gln Ser 
    1370                 1375                 1380             


Arg Glu  Ser Gln Cys 
    1385             


<210>  8
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV small envelope protein

<400>  8

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A cleavage fragment

<400>  9

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly 
            20      


<210>  10
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HBV small envelope protein

<400>  10

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
225                 230                 235                 240 


Asp Val Glu Glu Asn Pro Gly 
                245         


<210>  11
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core protein amino acids 1-149

<400>  11

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys 
                85                  90                  95      


Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val 
145                 


<210>  12
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core protein amino acids 1-149

<400>  12

Pro Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu 
            20                  25                  30          


Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His 
        35                  40                  45              


Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly 
    50                  55                  60                  


Glu Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro 
65                  70                  75                  80  


Ala Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu 
                85                  90                  95      


Lys Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
            100                 105                 110         


Arg Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
        115                 120                 125             


Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 
    130                 135                 140                 


Pro Glu Thr Thr Val Val Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
145                 150                 155                 160 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                165                 170     


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A cleavage fragment

<400>  13

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly 
            20  


<210>  14
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV large envelope protein

<400>  14

Pro Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn 
1               5                   10                  15      


Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp 
            20                  25                  30          


Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro 
        35                  40                  45              


Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe 
    50                  55                  60                  


Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro 
65                  70                  75                  80  


Gln Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala 
                85                  90                  95      


Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro 
            100                 105                 110         


Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 
        115                 120                 125             


His Gln Ala Leu Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala 
    130                 135                 140                 


Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser 
145                 150                 155                 160 


Pro Ile Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met 
                165                 170                 175     


Glu Asn Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala 
            180                 185                 190         


Gly Phe Leu Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 
        195                 200                 205             


Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr Cys Pro 
    210                 215                 220                 


Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys 
225                 230                 235                 240 


Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 
                245                 250                 255     


Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 
            260                 265                 270         


Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr 
        275                 280                 285             


Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Thr Ile Pro Ala Gln 
    290                 295                 300                 


Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly 
305                 310                 315                 320 


Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Phe 
                325                 330                 335     


Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 
            340                 345                 350         


Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 
        355                 360                 365             


Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu 
    370                 375                 380                 


Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 
385                 390                 395                 400 


Ile Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                405                 410                 415     


Glu Glu Asn Pro Gly 
            420     


<210>  15
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core protein

<400>  15

Pro Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu 
            20                  25                  30          


Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His 
        35                  40                  45              


Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly 
    50                  55                  60                  


Glu Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro 
65                  70                  75                  80  


Ala Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu 
                85                  90                  95      


Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
            100                 105                 110         


Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
        115                 120                 125             


Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 
    130                 135                 140                 


Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg 
145                 150                 155                 160 


Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg 
                165                 170                 175     


Ser Gln Ser Arg Glu Ser Gln Cys 
            180                 


<210>  16
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV RT domain of polymerase

<400>  16

Pro Glu Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile Arg 
1               5                   10                  15      


Ile Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp 
            20                  25                  30          


Lys Asn Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser 
        35                  40                  45              


Gln Phe Ser Arg Gly Lys Thr Arg Val Ser Trp Pro Lys Phe Ala Val 
    50                  55                  60                  


Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 
65                  70                  75                  80  


Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro Leu His Pro 
                85                  90                  95      


Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr 
            100                 105                 110         


Val Ala Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn His Gln His Gly 
        115                 120                 125             


Asn Leu Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser 
    130                 135                 140                 


Leu Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu Tyr Ser 
145                 150                 155                 160 


His Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu 
                165                 170                 175     


Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 
            180                 185                 190         


Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val 
        195                 200                 205             


Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala 
    210                 215                 220                 


Val Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 
225                 230                 235                 240 


Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly 
                245                 250                 255     


Ser Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile Lys Gln 
            260                 265                 270         


Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys 
        275                 280                 285             


Gln Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys 
    290                 295                 300                 


Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln 
305                 310                 315                 320 


Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr 
                325                 330                 335     


Leu Asn Leu Tyr Pro Val Ala Arg Gln Gly Ser Gly Glu Gly Arg Gly 
            340                 345                 350         


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        355                 360                 365 


<210>  17
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P7.5 promoter

<400>  17
tccaaaccca cccgcttttt atagtaagtt tttcaccata aataataaat aaataattaa       60

tttctcgtaa aagtagaaaa tatattctaa tttattgcac gg                         102


<210>  18
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PH5 promoter

<400>  18
taatcgtgtc atattagtat aaaaagtgat ttatttttac aaaattatgt attttgttct       60

atcaactacc tataaaactt tccctgcagg tcagcttaaa aattgaaatt ttattttttt      120

tttttggaat ataaataa                                                    138


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S190 peptide

<400>  19

Val Trp Leu Ser Val Ile Trp Met 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MVA B8R peptide

<400>  20

Thr Ser Tyr Lys Phe Glu Ser Val 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S208 peptide

<400>  21

Ile Leu Ser Pro Phe Leu Pro Leu 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S208 adw peptide

<400>  22

Ile Val Ser Pro Phe Ile Pro Leu 
1               5               


<210>  23
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S Pool peptide

<400>  23

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Thr Ala 
        115                 120                 125             


Gln Gly Thr Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 


Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C93 peptide

<400>  24

Met Gly Leu Lys Phe Arg Gln Leu 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-Gal96 peptide

<400>  25

Asp Ala Pro Ile Tyr Thr Asn Val 
1               5               


<210>  26
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  27
<211>  6512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vaccination vector

<400>  27
cctgggacat acgtatattt ctatgatctg tcttatatga agtctataca gcgaatagat       60

tcagaatttc tacataatta tatattgtac gctaataagt ttaatctaac actccccgaa      120

gatttgttta taatccctac aaatttggat attctatggc gtacaaagga atatatagac      180

tcgttcgata ttagtacaga aacatggaat aaattattat ccaattatta tatgaagatg      240

atagagtatg ctaaacttta tgtactaagt cctattctcg ctgaggagtt ggataatttt      300

gagaggacgg gagaattaac tcgaggccgc tggtacccaa cctaaaaatt gaaaataaat      360

acaaaggttc ttgagggttg tgttaaattg aaagcgagaa ataatcataa ataagcccgg      420

ggatcaacca tggacatcga cccttataaa gaatttggag ctactgtgga gttactctcg      480

tttttgcctt ctgacttctt tccttcagta cgagatcttc tagataccgc ctcagctctg      540

tatcgggaag ccttagagtc tcctgagcat tgttcacctc accatactgc actcaggcaa      600

gcaattcttt gctgggggga actaatgact ctagctacct gggtgggtgt taatttggaa      660

gatccagcgt ctagagacct agtagtcagt tatgtcaaca ctaatatggg cctaaagttc      720

aggcaactct tgtggtttca catttcttgt ctcacttttg gaagagaaac agttatagag      780

tatttggtgt ctttcggagt gtggattcgc actcctccag cttatagacc accaaatgcc      840

cctatcctat caacacttcc ggagactact gttgttagac gacgaggcag gtcccctaga      900

agaagaactc cctcgcctcg cagacgaagg tctcaatcgc cgcgtcgcag aagatctcaa      960

tctcgggaat ctcaatgtgg ctccggagcc accaacttct ccctgctgaa gcaggccggc     1020

gacgtggagg agaaccccgg cccttgctgg aattcgccct tatcgaccca agtaccgcca     1080

cctaaggcga tgccggagga gggttcgggc tgctcggtgc ggcgcaggcc ctatgggtgc     1140

gtcctgcggg ctgctttggt cccattggtc gcgggcttgg tgatctgcct cgtggtgtgc     1200

atccagcgct tcgcacaggc tcagcagcag ctgccgctcg agtcacttgg gtgggacgta     1260

gctgagctgc agctgaatca cacaggacct cagcaggacc ccaggctata ctggcagggg     1320

ggcccagcac tgggccgctc cttcctgcat ggaccagagc tggacaaggg gcagctacgt     1380

atccatcgtg atggcatcta catggtacac atccaggtga cgctggccat ctgctcctcc     1440

acgacggcct ccaggcacca ccccaccacc ctggccgtgg gaatctgctc tcccgcctcc     1500

cgtagcatca gcctgctgcg tctcagcttc caccaaggtt gtaccattgc ctcccagcgc     1560

ctgacgcccc tggcccgagg ggacacactc tgcaccaacc tcactgggac acttttgcct     1620

tcccgaaaca ctgatgagac cttctttgga gtgcagtggg tgcgcccctg attgacccgc     1680

gggcccggga tccgcccctc tccctccccc ccccctaacg ttactggccg aagccgcttg     1740

gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc gtcttttggc     1800

aatgtgaggg cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc     1860

cctctcgcca aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa     1920

gcttcttgaa gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct     1980

ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca     2040

caaccccagt gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca     2100

agcgtattca acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat     2160

ctggggcctc ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc     2220

cccccgaacc acggggacgt ggttttcctt tgaaaaacac gatgataata tggccacaac     2280

catggtgagc aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga     2340

cggcgacgta aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta     2400

cggcaagctg accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac     2460

cctcgtgacc accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa     2520

gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt     2580

cttcaaggac gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct     2640

ggtgaaccgc atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca     2700

caagctggag tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa     2760

cggcatcaag gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc     2820

cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca     2880

ctacctgagc acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt     2940

cctgctggag ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta     3000

aagcggccgc gactctagat cataatcagc cataccacat ttgtagaggt tttacttgct     3060

ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt     3120

gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     3180

acaaataaag catttttttc actgcattct agttgtggtt tgtcgtcgac ctgcagtcaa     3240

actctaatga ccacatcttt ttttagagat gaaaaatttt ccacatctcc ttttgtagac     3300

acgactaaac attttgcaga aaaaagttta ttagtgttta gataatcgta tacttcatca     3360

gtgtagatag taaatgtgaa cagataaaag gtattcttgc tcaatagatt ggtaaattcc     3420

atagaatata ttaatccttt cttcttgaga tcccacatca tttcaaccag agacgtttta     3480

tccaatgatt tacctcgtac tataccacat acaaaactag attttgcagt gacgtcgtat     3540

ctggtattcc taccaaacaa aattttactt ttagttcttt tagaaaattc taaggtagaa     3600

tctctatttg ccaatatgtc atctatggaa ttaccactag caaaaaatga tagaaatata     3660

tattgataca tcgcagctgg ttttgatcta ctatacttta aaaacgaatc agattccata     3720

attgcctgta tatcatcagc tgaaaaacta tgttttacac gtattccttc ggcatttctt     3780

tttaatgata tatcttgttt agacaatgat aaagttatca tgtccatgag agacgcgtct     3840

ccgtatcgta taaatatttc attagatgtt agacgcttca ttaggggtat acttctataa     3900

ggtttcttaa tcagtccatc attggttgcg tcaagaacta ctatcggatg ttgttgggta     3960

tctctagtgt tacacatggc cttactaaag tttgggtaaa taactatgat atctctatta     4020

attatagatg catatatttc atttgtcaag gatattagta tcgacttgct atcgtcatta     4080

atacgtgtaa tgtaatcata taaatcatgc gatagccaag gaaaatttaa atagatgttc     4140

atcatataat cgtcgctata attcatatta atacgttgac attgactaat ttgtaatata     4200

gcctcgccac gaagaaagct ctcgtattca gtttcatcga taaaggatac cgttaaatat     4260

aactggttgc cgatagtctc atagtctatt aagtggtaag tttcgtacaa atacagaatc     4320

cctaaaatat tatctaatgt tggattaatc tttaccataa ctgtataaaa tggagacgga     4380

gtcataacta ttttaccgtt tgtacttact ggaatagacg aaggaataat ctccggacat     4440

gctggtaaag acccaaatgt ctgtttgaag aaatccaatg ttccaggtcc taatctctta     4500

acaaaaatta cgatattcga tcccgatatc ctttgcattc tatttaccag catatcacga     4560

actatattaa gattatctat catgtctatt ctcccaccgt tatataaatc gcctccgcta     4620

agaaacgtta gtatatccat acaatggaat acttcatttc taaaatagta ttcgttttct     4680

aattctttaa tgtgaaatcg tatactagaa agggaaaaat tatctttgag ttttccgtta     4740

gaaaagaacc acgaaactaa tgttctgatt gcgtccgatt ccgttgctga attaatggat     4800

ttacaccaaa aactcatata acttctagat gtagaagcat tcgctaaaaa attagtagaa     4860

tcaaaggata taagtagatg ttccaacaag tgagcaattc ccaagatttc atctatatca     4920

ttctcgaatc cgaaattaga aattcccaag tagatatcct ttttcatccg atcgttgatg     4980

aaaatacgaa ctttattcgg taagacaatc atatggaaaa gaatttacca gatatcttct     5040

tttttccaaa ctgcgttaat gtattctctt acaaatattc acaagatgaa ttcagtaata     5100

tgagtaaaac ggaacgtgat agtttctcat tggcggtgtt tccagttata aaacatagat     5160

ggcataacgc acacgttgta aaacataaag gaatatacaa agttagtaca gaagcacgtg     5220

gaaaaaaagt atctcctcca tcactaggaa aacccgcaca cataaaccta accgcgaagc     5280

aatatatata cagtgaacac acaataagct ttgaatgtta tagttttcta aaatgtataa     5340

caaatacaga aatcaattcg ttcgatgagt atatattaag aggactatta gaagctggta     5400

atagtttaca gatattttcc aattccgtag gtaaacgaac agatactata ggtgtactag     5460

ggaataagta tccatttagc aaaattccat tggcctcatt aactcctaaa gcacaacgag     5520

agatattttc agcgtggatt tctcatagac ctgtagtttt aactggagga actggagtgg     5580

gtaagacgtc acaggtaccc aagttattgc tttggtttaa ttatttattt ggtggattct     5640

ctactctaga taaaatcact gactttcacg aaagaccagt cattctatct cttcctagga     5700

tagctttagt tagattgcat agcaatacca ttttaaaatc attgggattt aaggtactag     5760

atggatctcc tatttcttta cggtacggat ctataccgga agaattaata aacaaacaac     5820

caaaaaaata tggaattgta ttttctaccc ataagttatc tctaacaaaa ctatttagtt     5880

atggcactct tattatagac gaagttcatg agcatgatca aataggagat attattatag     5940

cagtagcgag aaagcatcat acgaaaatag attctatgtt tttaatgact gccacgttag     6000

aggatgacag ggaacggcta aaagtatttt tacctaatcc cgcatttata catattcctg     6060

gagatacact gtttaaaatt agcgaggtat ttattcataa taagataaat ccatcttcca     6120

gaatggcata catagaagaa gaaaagagaa atttagttac tgctatacag atgtatactc     6180

ctcctgatgg atcatccggt atagtctttg tggcatccgt tgcacagtgt cacgaatata     6240

aatcatattt agaaaaaaga ttaccgtatg atatgtatat tattcatggt aaggtcttag     6300

atatagacga aatattagaa aaagtgtatt catcacctaa tgtatcgata attatttcta     6360

ctccttattt ggaatccagc gttactatac gcaatgttac acacatttat gatatgggta     6420

gagtttttgt ccccgctcct tttggaggat cgcaagaatt tatttctaaa tctatgagag     6480

atcaacgaaa aggaagagta ggaagagtta at                                   6512


