                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  Խĸϸ

<130>  PIDC1154557P

<160>  143   

<170>  PatentIn version 3.3

<210>  1
<211>  503
<212>  PRT
<213>  Artificial

<220>
<223>  ǶϿԭİ

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Gly Ile Arg Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Ile Val Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
            100                 105                 110         


Gln His His Ser Tyr Pro Leu Thr Ser Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Gly Ser Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Phe Val Pro Val Phe Leu 
            260                 265                 270         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  2
<211>  1512
<212>  DNA
<213>  Artificial

<220>
<223>  ǶϿԭĺӵĺ

<400>  2
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aa                                                       1512


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  3
ggccaggatg gttcttagac t                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  4
ggatttccag tggcgagaga a                                               21


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  5
gccuguguuc ucuguggacu aug                                             23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  6
ggugcugcua gucugggucc ugg                                             23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  7
gacagagaga agggcagaag ugc                                             23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  8
cagcuucucc aacacaucgg aga                                             23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  9
ccgugucaca caacugccca acg                                             23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  10
uaugccacca uugucuuucc uag                                             23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  11
ugcuaaacug guaccgcaug agc                                             23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  12
gugacagaga gaagggcaga agu                                             23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  13
cugaggaugg acacugcucu ugg                                             23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  14
aucggagagc uucgugcuaa acu                                             23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  15
ggcaacggaa cccagattta t                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  16
ggaacccaaa ttacgtgtac t                                               21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  17
gaacccaaat tacgtgtact a                                               21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  18
gggagaagac tatattgtac a                                               21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  19
gacgtttata gccgaaatga t                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  20
gacactaata caccaggtag a                                               21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  21
accucacuau ccaaggacug agg                                             23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  22
augaguugac cuuccuagau gau                                             23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  23
ggggaaugag uugaccuucc uag                                             23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  24
cucuggaucc uugcagcagu uag                                             23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  25
cuccucugga uccuugcagc agu                                             23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  26
uuugugugug aguaugcauc ucc                                             23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  27
caccuccagu ggaaaucaag uga                                             23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  28
cacgggacuc uacaucugca agg                                             23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  29
uucugacuuc cuccucugga ucc                                             23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  30
aagucugugc ggcaaccuac aug                                             23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  31
ggtcggtcag aatgcctatc t                                               21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  32
gccaatgact tacgggactc t                                               21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  33
gcagagggaa ttcgctcaga a                                               21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  34
ggaaattcgg gcacatcata t                                               21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  35
gattaagaga tgactggact a                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  36
gagatgactg gactaggtct a                                               21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  37
aggaaauucg ggcacaucau aug                                             23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  38
gacugaugaa agggauguga auu                                             23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  39
gccacugauu uucaaagaga ucu                                             23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  40
agcagaguuu ucccauuuuc aga                                             23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  41
aacuuaaaca ggcaugucau ugc                                             23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  42
uucagaagau aaugacucac aug                                             23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  43
gccucuguau uuaagccaac aga                                             23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  44
ugcucaugug auuguggagu aga                                             23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  45
auguuuucac aucuucccuu uga                                             23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  46
gagagacuuc acugcagccu uuc                                             23


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  47
gattgcctct actcatcact a                                               21


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  48
uccuaaugac aaugggucau acc                                             23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  49
aagacauugc cugccaugcu ugg                                             23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  50
gucauaccgc uguucugcaa auu                                             23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  51
cuccuguaua guuuacuucc uuu                                             23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  52
uaccgcuguu cugcaaauuu uca                                             23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  53
aaaacaaacc aggcauuguu uau                                             23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  54
aacuagaaug cccugugaaa uac                                             23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  55
gugacuuggu gcaagcucaa ugg                                             23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  56
auccauggga aagaaucaug uga                                             23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  57
uggugcaagc ucaauggaac aac                                             23


<210>  58
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  58
gctgctcacc cttatgaacc t                                               21


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  59
aggacauggu gguggacgag ugc                                             23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  60
ugcucuuccu gcacgauauc agu                                             23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  61
accucuacug guuccuguac auc                                             23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  62
cccuccaacu cugcuccucu agg                                             23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  63
cccugagugg acagucgucu ucg                                             23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  64
cugcuccagg gaagcuucua ugg                                             23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  65
cgcucaaggu ccuguaugcc acc                                             23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  66
gaguucacca agcucaacau uua                                             23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  67
ugcugcugcu cacccuuaug aac                                             23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  68
cccaucuccg ugcucuucuu uga                                             23


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  69
gggacatcgt cgagctattc a                                               21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  70
ggacatcgtc gagctattca t                                               21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  71
gccaatgtca ccgtggataa t                                               21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  72
gtcatctgtg gcagtatatc a                                               21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  73
ggatgtagag tagtgttaga t                                               21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  74
ggcaaagtta agaccatcaa t                                               21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  75
gaccaaatcc acgctcaatt a                                               21


<210>  76
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  76
uacugcuuaa aucuuccauc agc                                             23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  77
gacugagaag uucugucuga uuu                                             23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  78
cuguuucauc acccaaacau acu                                             23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  79
gaagauccuc ccacaucacu aaa                                             23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  80
uagaccaagg uaaaagugga aca                                             23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  81
aagagguuuu uaucugagcu uga                                             23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  82
uaccugcaca acguucaacc aug                                             23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  83
gccuggauuc augucucuca uuu                                             23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  84
cccucggaau uucucugcca agc                                             23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  85
ugcugaagau ccucccacau cac                                             23


<210>  86
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  86
gcacctccta cctcttcatg t                                               21


<210>  87
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  87
cgcacuuccg cacauuccgu ucg                                             23


<210>  88
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  88
ggggaggguc ucuggcuuua uuu                                             23


<210>  89
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  89
cagcauuaac ugggaugccg ugu                                             23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  90
ccaggaccug aacucgcacc ucc                                             23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  91
uacauauacc caguaucuuu gca                                             23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  92
gccgacaaug cagucuccac agc                                             23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  93
ccccugguug uuguagcagc uua                                             23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  94
cugcugugca gaauccuauu uua                                             23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  95
ugggaugccg uguuauuuug uua                                             23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  96
ucgcaccucc uaccucuuca ugu                                             23


<210>  97
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  97
gcggaaagct gtgaagatac g                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  98
acaaagccct catcgacaga a                                               21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  99
atgccacttc tcagtacatg t                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  100
gtggacttca gtacaactca c                                               21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  101
gtggaattta cttgcctctc c                                               21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  102
gttggatgaa gctaacttac c                                               21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  103
actgggaaga cgtgtaactc t                                               21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  104
aaggaattgc atccaaggta t                                               21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  105
ggaattgcat ccaaggtata c                                               21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  106
ggatgagact ggcaatggtc a                                               21


<210>  107
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  107
uccucaguuu cgggagauca ucc                                             23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  108
gagucucuca aaucucagga auu                                             23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  109
agcucuaguc cuuuuugugu aau                                             23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  110
cacuggaaau guucagaacu ugc                                             23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  111
augaugaaug ggacaaucuu auc                                             23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  112
cacacugugu uucaucgagu aca                                             23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  113
gcagaaccau ccauggacug uga                                             23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  114
aaagaugugg ccuuuuguga ugg                                             23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  115
uucagaacuu gccaguuuug ucc                                             23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  116
augagacugg caauggucac agg                                             23


<210>  117
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  117
gtcaattcca gggagataac t                                               21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  118
gcctggaagc aatggctcta a                                               21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  119
gcaccaaacc cggaagctat a                                               21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  120
gttgcactcg attgggacag t                                               21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  121
ggattatgtg aacctacacc t                                               21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  122
ggaatcacag cgagttcaaa t                                               21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  123
gcaaggcata gtctcattga a                                               21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  124
ggtgaagaga gccttagaga t                                               21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  125
gtgaagagag ccttagagat a                                               21


<210>  126
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  126
aggagcuaag gucuuuucca aug                                             23


<210>  127
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  127
augucgaugc aaaaauugca aaa                                             23


<210>  128
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  128
gucacaugcu ggcagaaauc aaa                                             23


<210>  129
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  129
uccagguuac auggcauuuc uca                                             23


<210>  130
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  130
uugaacuuug aaccugugaa aug                                             23


<210>  131
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  131
uccacaucaa cagcuaaauc auu                                             23


<210>  132
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  132
augcuggcag aaaucaaagc aau                                             23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  133
ugcagagaau gacaaagaug uca                                             23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  134
ggcagaacuc accagucaca uca                                             23


<210>  135
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  135
ucgguccugu gauaaugguc acu                                             23


<210>  136
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  ޹EGFRİ

<400>  136

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Arg Lys Val Cys Asn Gly Ile Gly Ile 
            20                  25                  30          


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        35                  40                  45              


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    50                  55                  60                  


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
65                  70                  75                  80  


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                85                  90                  95      


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            100                 105                 110         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        115                 120                 125             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    130                 135                 140                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
145                 150                 155                 160 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                165                 170                 175     


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
            180                 185                 190         


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
        195                 200                 205             


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
    210                 215                 220                 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
225                 230                 235                 240 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
                245                 250                 255     


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
            260                 265                 270         


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
        275                 280                 285             


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
    290                 295                 300                 


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
305                 310                 315                 320 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                325                 330                 335     


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            340                 345                 350         


Gly Ile Gly Leu Phe Met Arg Arg 
        355                 360 


<210>  137
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  ޹EGFRĺӵĺ

<400>  137
atggctctgc ccgtcaccgc tctgctgctg cctctggctc tgctgctgca cgccgcacgc     60

cctgggagtc gcaaagtctg taatgggatc ggcatcggcg agttcaagga cagcctgtcc    120

atcaacgcca ccaatatcaa gcactttaag aattgcacat ctatcagcgg cgacctgcac    180

atcctgccag tggccttccg gggcgattct tttacccaca caccccctct ggaccctcag    240

gagctggata tcctgaagac cgtgaaggag atcacaggct tcctgctgat ccaggcctgg    300

cctgagaaca gaaccgatct gcacgccttt gagaatctgg agatcatccg gggcagaaca    360

aagcagcacg gccagttctc cctggccgtg gtgtctctga acatcaccag cctgggcctg    420

aggtccctga aggagatctc tgacggcgat gtgatcatct ccggcaacaa gaacctgtgc    480

tacgccaaca caatcaattg gaagaagctg tttggcacct ctggccagaa gacaaagatc    540

atctctaacc ggggcgagaa tagctgcaag gcaaccggac aggtgtgcca cgcactgtgc    600

agcccagagg gatgttgggg cccagagcca cgggactgcg tgagctgtag aaacgtgtcc    660

aggggccgcg agtgcgtgga taagtgtaat ctgctggagg gcgagccaag ggagttcgtg    720

gagaactccg agtgcatcca gtgtcacccc gagtgcctgc ctcaggccat gaacatcacc    780

tgtacaggcc gcggccccga caattgcatc cagtgtgccc actatatcga tggccctcac    840

tgcgtgaaga cctgtccagc cggcgtgatg ggcgagaaca atacactggt gtggaagtac    900

gcagacgcag gacacgtgtg ccacctgtgc caccccaatt gcacctatgg ctgtacagga    960

ccaggcctgg agggatgccc aaccaacggc cctaagatcc caagcatcgc cacaggcatg   1020

gtgggggcac tgctgctgct gctggtggtg gctctgggga ttgggctgtt tatgagaagg   1080

taa                                                                 1083


<210>  138
<211>  4128
<212>  DNA
<213>  Artificial

<220>
<223>  EvIII-CAR/iPD1-CBL-B/ tEGFRĺ

<400>  138
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aatcctactg cgtcgacttc gaatttaaat cggatccgcg gccgcgcccc   1560

tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg   1620

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa   1680

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg   1740

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca   1800

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc   1860

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt   1920

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg   1980

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca   2040

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac   2100

gtggttttcc tttgaaaaac acgatgataa tatggccaca accatggcgt ccggatctag   2160

aatggctctg cccgtcaccg ctctgctgct gcctctggct ctgctgctgc acgccgcacg   2220

ccctgggagt cgcaaagtct gtaatgggat cggcatcggc gagttcaagg acagcctgtc   2280

catcaacgcc accaatatca agcactttaa gaattgcaca tctatcagcg gcgacctgca   2340

catcctgcca gtggccttcc ggggcgattc ttttacccac acaccccctc tggaccctca   2400

ggagctggat atcctgaaga ccgtgaagga gatcacaggc ttcctgctga tccaggcctg   2460

gcctgagaac agaaccgatc tgcacgcctt tgagaatctg gagatcatcc ggggcagaac   2520

aaagcagcac ggccagttct ccctggccgt ggtgtctctg aacatcacca gcctgggcct   2580

gaggtccctg aaggagatct ctgacggcga tgtgatcatc tccggcaaca agaacctgtg   2640

ctacgccaac acaatcaatt ggaagaagct gtttggcacc tctggccaga agacaaagat   2700

catctctaac cggggcgaga atagctgcaa ggcaaccgga caggtgtgcc acgcactgtg   2760

cagcccagag ggatgttggg gcccagagcc acgggactgc gtgagctgta gaaacgtgtc   2820

caggggccgc gagtgcgtgg ataagtgtaa tctgctggag ggcgagccaa gggagttcgt   2880

ggagaactcc gagtgcatcc agtgtcaccc cgagtgcctg cctcaggcca tgaacatcac   2940

ctgtacaggc cgcggccccg acaattgcat ccagtgtgcc cactatatcg atggccctca   3000

ctgcgtgaag acctgtccag ccggcgtgat gggcgagaac aatacactgg tgtggaagta   3060

cgcagacgca ggacacgtgt gccacctgtg ccaccccaat tgcacctatg gctgtacagg   3120

accaggcctg gagggatgcc caaccaacgg ccctaagatc ccaagcatcg ccacaggcat   3180

ggtgggggca ctgctgctgc tgctggtggt ggctctgggg attgggctgt ttatgagaag   3240

gtaatcctac tgcgaattcg tcgaccgact gtgccttcta gttgccagcc atctgttgtt   3300

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa   3360

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg   3420

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg   3480

gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg cctatttccc atgattcctt   3540

catatttgca tatacgatac aaggctgtta gagagataat tagaattaat ttgactgtaa   3600

acacaaagat attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg   3660

cagttttaaa attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt   3720

tcgatttctt ggctttatat atcttgtgga aaggacgaaa cacctcccca ggcgcagatc   3780

aaagagagtt caagagactc tctttgatct gcgccttttt tagctatcga tagctaaaaa   3840

aacacagacg ccatgatttg ctctcttgaa gcaaatcatg gcgtctgtgt tggggaagat   3900

ctgtggtctc atacagaact tataagattc ccaaatccaa agacatttca cgtttatggt   3960

gatttcccag aacacatagc gacatgcaaa tattgcaggg cgccactccc ctgtccctca   4020

cagccatctt cctgccaggg cgcacgcgcg ctgggtgttc ccgcctagtg acactgggcc   4080

cgcgattcct tggagcgggt tgatgacgtc agcgttcgaa ttgtcgac                4128


<210>  139
<211>  3802
<212>  DNA
<213>  Artificial

<220>
<223>  EvIII-CAR/iCBL-B/tEGFRĺ

<400>  139
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aatcctactg cgtcgacttc gaatttaaat cggatccgcg gccgcgcccc   1560

tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg   1620

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa   1680

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg   1740

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca   1800

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc   1860

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt   1920

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg   1980

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca   2040

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac   2100

gtggttttcc tttgaaaaac acgatgataa tatggccaca accatggcgt ccggatctag   2160

aatggctctg cccgtcaccg ctctgctgct gcctctggct ctgctgctgc acgccgcacg   2220

ccctgggagt cgcaaagtct gtaatgggat cggcatcggc gagttcaagg acagcctgtc   2280

catcaacgcc accaatatca agcactttaa gaattgcaca tctatcagcg gcgacctgca   2340

catcctgcca gtggccttcc ggggcgattc ttttacccac acaccccctc tggaccctca   2400

ggagctggat atcctgaaga ccgtgaagga gatcacaggc ttcctgctga tccaggcctg   2460

gcctgagaac agaaccgatc tgcacgcctt tgagaatctg gagatcatcc ggggcagaac   2520

aaagcagcac ggccagttct ccctggccgt ggtgtctctg aacatcacca gcctgggcct   2580

gaggtccctg aaggagatct ctgacggcga tgtgatcatc tccggcaaca agaacctgtg   2640

ctacgccaac acaatcaatt ggaagaagct gtttggcacc tctggccaga agacaaagat   2700

catctctaac cggggcgaga atagctgcaa ggcaaccgga caggtgtgcc acgcactgtg   2760

cagcccagag ggatgttggg gcccagagcc acgggactgc gtgagctgta gaaacgtgtc   2820

caggggccgc gagtgcgtgg ataagtgtaa tctgctggag ggcgagccaa gggagttcgt   2880

ggagaactcc gagtgcatcc agtgtcaccc cgagtgcctg cctcaggcca tgaacatcac   2940

ctgtacaggc cgcggccccg acaattgcat ccagtgtgcc cactatatcg atggccctca   3000

ctgcgtgaag acctgtccag ccggcgtgat gggcgagaac aatacactgg tgtggaagta   3060

cgcagacgca ggacacgtgt gccacctgtg ccaccccaat tgcacctatg gctgtacagg   3120

accaggcctg gagggatgcc caaccaacgg ccctaagatc ccaagcatcg ccacaggcat   3180

ggtgggggca ctgctgctgc tgctggtggt ggctctgggg attgggctgt ttatgagaag   3240

gtaatcctac tgcgaattcg tcgaccgact gtgccttcta gttgccagcc atctgttgtt   3300

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa   3360

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg   3420

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg   3480

gtgggctcta tgggtcgaca tcgatagcta aaaaaacaca gacgccatga tttgctctct   3540

tgaagcaaat catggcgtct gtgttgggga agatctgtgg tctcatacag aacttataag   3600

attcccaaat ccaaagacat ttcacgttta tggtgatttc ccagaacaca tagcgacatg   3660

caaatattgc agggcgccac tcccctgtcc ctcacagcca tcttcctgcc agggcgcacg   3720

cgcgctgggt gttcccgcct agtgacactg ggcccgcgat tccttggagc gggttgatga   3780

cgtcagcgtt cgaattgtcg ac                                            3802


<210>  140
<211>  3831
<212>  DNA
<213>  Artificial

<220>
<223>  EvIII-CAR/iPD1/ tEGFRĺ

<400>  140
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aatcctactg cgtcgacttc gaatttaaat cggatccgcg gccgcgcccc   1560

tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg   1620

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa   1680

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg   1740

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca   1800

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc   1860

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt   1920

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg   1980

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca   2040

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac   2100

gtggttttcc tttgaaaaac acgatgataa tatggccaca accatggcgt ccggatctag   2160

aatggctctg cccgtcaccg ctctgctgct gcctctggct ctgctgctgc acgccgcacg   2220

ccctgggagt cgcaaagtct gtaatgggat cggcatcggc gagttcaagg acagcctgtc   2280

catcaacgcc accaatatca agcactttaa gaattgcaca tctatcagcg gcgacctgca   2340

catcctgcca gtggccttcc ggggcgattc ttttacccac acaccccctc tggaccctca   2400

ggagctggat atcctgaaga ccgtgaagga gatcacaggc ttcctgctga tccaggcctg   2460

gcctgagaac agaaccgatc tgcacgcctt tgagaatctg gagatcatcc ggggcagaac   2520

aaagcagcac ggccagttct ccctggccgt ggtgtctctg aacatcacca gcctgggcct   2580

gaggtccctg aaggagatct ctgacggcga tgtgatcatc tccggcaaca agaacctgtg   2640

ctacgccaac acaatcaatt ggaagaagct gtttggcacc tctggccaga agacaaagat   2700

catctctaac cggggcgaga atagctgcaa ggcaaccgga caggtgtgcc acgcactgtg   2760

cagcccagag ggatgttggg gcccagagcc acgggactgc gtgagctgta gaaacgtgtc   2820

caggggccgc gagtgcgtgg ataagtgtaa tctgctggag ggcgagccaa gggagttcgt   2880

ggagaactcc gagtgcatcc agtgtcaccc cgagtgcctg cctcaggcca tgaacatcac   2940

ctgtacaggc cgcggccccg acaattgcat ccagtgtgcc cactatatcg atggccctca   3000

ctgcgtgaag acctgtccag ccggcgtgat gggcgagaac aatacactgg tgtggaagta   3060

cgcagacgca ggacacgtgt gccacctgtg ccaccccaat tgcacctatg gctgtacagg   3120

accaggcctg gagggatgcc caaccaacgg ccctaagatc ccaagcatcg ccacaggcat   3180

ggtgggggca ctgctgctgc tgctggtggt ggctctgggg attgggctgt ttatgagaag   3240

gtaatcctac tgcgaattcg tcgaccgact gtgccttcta gttgccagcc atctgttgtt   3300

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa   3360

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg   3420

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg   3480

gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg cctatttccc atgattcctt   3540

catatttgca tatacgatac aaggctgtta gagagataat tagaattaat ttgactgtaa   3600

acacaaagat attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg   3660

cagttttaaa attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt   3720

tcgatttctt ggctttatat atcttgtgga aaggacgaaa cacctcccca ggcgcagatc   3780

aaagagagtt caagagactc tctttgatct gcgccttttt tagctgtcga c            3831


<210>  141
<211>  4128
<212>  DNA
<213>  Artificial

<220>
<223>  EvIII-CAR/iPD1- CTLA4/ tEGFRĺ

<400>  141
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aatcctactg cgtcgacttc gaatttaaat cggatccgcg gccgcgcccc   1560

tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg   1620

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa   1680

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg   1740

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca   1800

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc   1860

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt   1920

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg   1980

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca   2040

tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac   2100

gtggttttcc tttgaaaaac acgatgataa tatggccaca accatggcgt ccggatctag   2160

aatggctctg cccgtcaccg ctctgctgct gcctctggct ctgctgctgc acgccgcacg   2220

ccctgggagt cgcaaagtct gtaatgggat cggcatcggc gagttcaagg acagcctgtc   2280

catcaacgcc accaatatca agcactttaa gaattgcaca tctatcagcg gcgacctgca   2340

catcctgcca gtggccttcc ggggcgattc ttttacccac acaccccctc tggaccctca   2400

ggagctggat atcctgaaga ccgtgaagga gatcacaggc ttcctgctga tccaggcctg   2460

gcctgagaac agaaccgatc tgcacgcctt tgagaatctg gagatcatcc ggggcagaac   2520

aaagcagcac ggccagttct ccctggccgt ggtgtctctg aacatcacca gcctgggcct   2580

gaggtccctg aaggagatct ctgacggcga tgtgatcatc tccggcaaca agaacctgtg   2640

ctacgccaac acaatcaatt ggaagaagct gtttggcacc tctggccaga agacaaagat   2700

catctctaac cggggcgaga atagctgcaa ggcaaccgga caggtgtgcc acgcactgtg   2760

cagcccagag ggatgttggg gcccagagcc acgggactgc gtgagctgta gaaacgtgtc   2820

caggggccgc gagtgcgtgg ataagtgtaa tctgctggag ggcgagccaa gggagttcgt   2880

ggagaactcc gagtgcatcc agtgtcaccc cgagtgcctg cctcaggcca tgaacatcac   2940

ctgtacaggc cgcggccccg acaattgcat ccagtgtgcc cactatatcg atggccctca   3000

ctgcgtgaag acctgtccag ccggcgtgat gggcgagaac aatacactgg tgtggaagta   3060

cgcagacgca ggacacgtgt gccacctgtg ccaccccaat tgcacctatg gctgtacagg   3120

accaggcctg gagggatgcc caaccaacgg ccctaagatc ccaagcatcg ccacaggcat   3180

ggtgggggca ctgctgctgc tgctggtggt ggctctgggg attgggctgt ttatgagaag   3240

gtaatcctac tgcgaattcg tcgaccgact gtgccttcta gttgccagcc atctgttgtt   3300

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa   3360

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg   3420

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg   3480

gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg cctatttccc atgattcctt   3540

catatttgca tatacgatac aaggctgtta gagagataat tagaattaat ttgactgtaa   3600

acacaaagat attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg   3660

cagttttaaa attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt   3720

tcgatttctt ggctttatat atcttgtgga aaggacgaaa cacctcccca ggcgcagatc   3780

aaagagagtt caagagactc tctttgatct gcgccttttt tagctatcga tagctaaaaa   3840

aacacagacg ccatgatttg ctctcttgaa gcaaatcatg gcgtctgtgt tggggaagat   3900

ctgtggtctc atacagaact tataagattc ccaaatccaa agacatttca cgtttatggt   3960

gatttcccag aacacatagc gacatgcaaa tattgcaggg cgccactccc ctgtccctca   4020

cagccatctt cctgccaggg cgcacgcgcg ctgggtgttc ccgcctagtg acactgggcc   4080

cgcgattcct tggagcgggt tgatgacgtc agcgttcgaa ttgtcgac                4128


<210>  142
<211>  616
<212>  DNA
<213>  Artificial

<220>
<223>  ڲλĺ

<400>  142
tttaaatcgg atccgcggcc gcgcccctct ccctcccccc cccctaacgt tactggccga     60

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg    120

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg    180

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt    240

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac    300

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca    360

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg    420

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg    480

ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa    540

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat    600

ggccacaacc atggcg                                                    616


<210>  143
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  143

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


