                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  ￹EGFRvIIIǶϿԭ߼Ʒӵתܰϸ
       ;

<130>  PIDC1153485P

<160>  139   

<170>  PatentIn version 3.3

<210>  1
<211>  503
<212>  PRT
<213>  Artificial

<220>
<223>  ǶϿԭİ

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Gly Ile Arg Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Ile Val Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
            100                 105                 110         


Gln His His Ser Tyr Pro Leu Thr Ser Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Gly Ser Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Phe Val Pro Val Phe Leu 
            260                 265                 270         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  2
<211>  1512
<212>  DNA
<213>  Artificial

<220>
<223>  ǶϿԭĺӵĺ

<400>  2
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccgggatccg acatccagat gacccagagc cctagcagcc tgagcgccag cgtgggcgac    120

agagtgacca tcacctgtcg ggccagccag ggcatcagaa acaacctggc ctggtatcag    180

cagaagcccg gcaaggcccc caagagactg atctacgctg ccagcaatct gcagagcggc    240

gtgcccagca gattcaccgg aagcggctcc ggcaccgagt tcaccctgat cgtgtccagc    300

ctgcagcccg aggacttcgc cacctactac tgcctgcagc accacagcta ccctctgacc    360

agcggcggag gcaccaaggt ggagatcaag cggaccggca gcaccagcgg cagcggcaag    420

cctggcagcg gcgagggaag cgaggtccag gtgctggaat ctggcggcgg actggtgcag    480

cctggcggca gcctgagact gagctgtgcc gccagcggct tcaccttcag cagctacgcc    540

atgtcttggg tccggcaggc tcctggaaag ggcctggaat gggtgtccgc catcagcggc    600

tctggcggct ccaccaacta cgccgacagc gtgaagggcc ggttcaccat cagccgggac    660

aacagcaaga acaccctgta tctgcagatg aacagcctga gagccgagga caccgccgtg    720

tactactgtg ccggcagcag cgggtggagc gagtactggg gccagggcac actggtcaca    780

gtgtctagcg cggccgcatt cgtgccggtc ttcctgccag cgaagcccac cacgacgcca    840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca    900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt    960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt   1020

atcacccttt actgcaacca caggaacaaa cggggcagaa agaaactcct gtatatattc   1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac   1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga   1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg   1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag   1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt   1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1500

ccccctcgct aa                                                       1512


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  3
ggccaggatg gttcttagac t                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  4
ggatttccag tggcgagaga a                                               21


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  5
gccuguguuc ucuguggacu aug                                             23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  6
ggugcugcua gucugggucc ugg                                             23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  7
gacagagaga agggcagaag ugc                                             23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  8
cagcuucucc aacacaucgg aga                                             23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  9
ccgugucaca caacugccca acg                                             23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  10
uaugccacca uugucuuucc uag                                             23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  11
ugcuaaacug guaccgcaug agc                                             23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  12
gugacagaga gaagggcaga agu                                             23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  13
cugaggaugg acacugcucu ugg                                             23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1siRNA

<400>  14
aucggagagc uucgugcuaa acu                                             23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  15
ggcaacggaa cccagattta t                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  16
ggaacccaaa ttacgtgtac t                                               21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  17
gaacccaaat tacgtgtact a                                               21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  18
gggagaagac tatattgtac a                                               21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  19
gacgtttata gccgaaatga t                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  20
gacactaata caccaggtag a                                               21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  21
accucacuau ccaaggacug agg                                             23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  22
augaguugac cuuccuagau gau                                             23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  23
ggggaaugag uugaccuucc uag                                             23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  24
cucuggaucc uugcagcagu uag                                             23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  25
cuccucugga uccuugcagc agu                                             23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  26
uuugugugug aguaugcauc ucc                                             23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  27
caccuccagu ggaaaucaag uga                                             23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  28
cacgggacuc uacaucugca agg                                             23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  29
uucugacuuc cuccucugga ucc                                             23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4siRNA

<400>  30
aagucugugc ggcaaccuac aug                                             23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  31
ggtcggtcag aatgcctatc t                                               21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  32
gccaatgact tacgggactc t                                               21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  33
gcagagggaa ttcgctcaga a                                               21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  34
ggaaattcgg gcacatcata t                                               21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  35
gattaagaga tgactggact a                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  36
gagatgactg gactaggtct a                                               21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  37
aggaaauucg ggcacaucau aug                                             23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  38
gacugaugaa agggauguga auu                                             23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  39
gccacugauu uucaaagaga ucu                                             23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  40
agcagaguuu ucccauuuuc aga                                             23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  41
aacuuaaaca ggcaugucau ugc                                             23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  42
uucagaagau aaugacucac aug                                             23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  43
gccucuguau uuaagccaac aga                                             23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  44
ugcucaugug auuguggagu aga                                             23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  45
auguuuucac aucuucccuu uga                                             23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3siRNA

<400>  46
gagagacuuc acugcagccu uuc                                             23


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  47
gattgcctct actcatcact a                                               21


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  48
uccuaaugac aaugggucau acc                                             23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  49
aagacauugc cugccaugcu ugg                                             23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  50
gucauaccgc uguucugcaa auu                                             23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  51
cuccuguaua guuuacuucc uuu                                             23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  52
uaccgcuguu cugcaaauuu uca                                             23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  53
aaaacaaacc aggcauuguu uau                                             23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  54
aacuagaaug cccugugaaa uac                                             23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  55
gugacuuggu gcaagcucaa ugg                                             23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  56
auccauggga aagaaucaug uga                                             23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLAsiRNA

<400>  57
uggugcaagc ucaauggaac aac                                             23


<210>  58
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  58
gctgctcacc cttatgaacc t                                               21


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  59
aggacauggu gguggacgag ugc                                             23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  60
ugcucuuccu gcacgauauc agu                                             23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  61
accucuacug guuccuguac auc                                             23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  62
cccuccaacu cugcuccucu agg                                             23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  63
cccugagugg acagucgucu ucg                                             23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  64
cugcuccagg gaagcuucua ugg                                             23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  65
cgcucaaggu ccuguaugcc acc                                             23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  66
gaguucacca agcucaacau uua                                             23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  67
ugcugcugcu cacccuuaug aac                                             23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG3siRNA

<400>  68
cccaucuccg ugcucuucuu uga                                             23


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  69
gggacatcgt cgagctattc a                                               21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  70
ggacatcgtc gagctattca t                                               21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  71
gccaatgtca ccgtggataa t                                               21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  72
gtcatctgtg gcagtatatc a                                               21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  73
ggatgtagag tagtgttaga t                                               21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  74
ggcaaagtta agaccatcaa t                                               21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  75
gaccaaatcc acgctcaatt a                                               21


<210>  76
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  76
uacugcuuaa aucuuccauc agc                                             23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  77
gacugagaag uucugucuga uuu                                             23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  78
cuguuucauc acccaaacau acu                                             23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  79
gaagauccuc ccacaucacu aaa                                             23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  80
uagaccaagg uaaaagugga aca                                             23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  81
aagagguuuu uaucugagcu uga                                             23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  82
uaccugcaca acguucaacc aug                                             23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  83
gccuggauuc augucucuca uuu                                             23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  84
cccucggaau uucucugcca agc                                             23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M (ϸ-1ؼø3) siRNA

<400>  85
ugcugaagau ccucccacau cac                                             23


<210>  86
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  86
gcacctccta cctcttcatg t                                               21


<210>  87
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  87
cgcacuuccg cacauuccgu ucg                                             23


<210>  88
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  88
ggggaggguc ucuggcuuua uuu                                             23


<210>  89
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  89
cagcauuaac ugggaugccg ugu                                             23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  90
ccaggaccug aacucgcacc ucc                                             23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  91
uacauauacc caguaucuuu gca                                             23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  92
gccgacaaug cagucuccac agc                                             23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  93
ccccugguug uuguagcagc uua                                             23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  94
cugcugugca gaauccuauu uua                                             23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  95
ugggaugccg uguuauuuug uua                                             23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1ϸźת1siRNA

<400>  96
ucgcaccucc uaccucuuca ugu                                             23


<210>  97
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  97
gcggaaagct gtgaagatac g                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  98
acaaagccct catcgacaga a                                               21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  99
atgccacttc tcagtacatg t                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  100
gtggacttca gtacaactca c                                               21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  101
gtggaattta cttgcctctc c                                               21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  102
gttggatgaa gctaacttac c                                               21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  103
actgggaaga cgtgtaactc t                                               21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  104
aaggaattgc atccaaggta t                                               21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  105
ggaattgcat ccaaggtata c                                               21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  106
ggatgagact ggcaatggtc a                                               21


<210>  107
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  107
uccucaguuu cgggagauca ucc                                             23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  108
gagucucuca aaucucagga auu                                             23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  109
agcucuaguc cuuuuugugu aau                                             23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  110
cacuggaaau guucagaacu ugc                                             23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  111
augaugaaug ggacaaucuu auc                                             23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  112
cacacugugu uucaucgagu aca                                             23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  113
gcagaaccau ccauggacug uga                                             23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  114
aaagaugugg ccuuuuguga ugg                                             23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  115
uucagaacuu gccaguuuug ucc                                             23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  116
augagacugg caauggucac agg                                             23


<210>  117
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  117
gtcaattcca gggagataac t                                               21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  118
gcctggaagc aatggctcta a                                               21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  119
gcaccaaacc cggaagctat a                                               21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  120
gttgcactcg attgggacag t                                               21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  121
ggattatgtg aacctacacc t                                               21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  122
ggaatcacag cgagttcaaa t                                               21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  123
gcaaggcata gtctcattga a                                               21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  124
ggtgaagaga gccttagaga t                                               21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  125
gtgaagagag ccttagagat a                                               21


<210>  126
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  126
aggagcuaag gucuuuucca aug                                             23


<210>  127
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  127
augucgaugc aaaaauugca aaa                                             23


<210>  128
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  128
gucacaugcu ggcagaaauc aaa                                             23


<210>  129
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  129
uccagguuac auggcauuuc uca                                             23


<210>  130
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  130
uugaacuuug aaccugugaa aug                                             23


<210>  131
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  131
uccacaucaa cagcuaaauc auu                                             23


<210>  132
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  132
augcuggcag aaaucaaagc aau                                             23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  133
ugcagagaau gacaaagaug uca                                             23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  134
ggcagaacuc accagucaca uca                                             23


<210>  135
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-BE3صøCBL-BsiRNA

<400>  135
ucgguccugu gauaaugguc acu                                             23


<210>  136
<211>  2143
<212>  DNA
<213>  Artificial

<220>
<223>  ￹EGFRvIIIǶϿԭͳĬϸ߼PD1ĺ
       EGFRvIII-CAR/iPD1

<400>  136
tctagagcta gcagatctat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     60

ctgctccacg ccgccaggcc gggatccgac atccagatga cccagagccc tagcagcctg    120

agcgccagcg tgggcgacag agtgaccatc acctgtcggg ccagccaggg catcagaaac    180

aacctggcct ggtatcagca gaagcccggc aaggccccca agagactgat ctacgctgcc    240

agcaatctgc agagcggcgt gcccagcaga ttcaccggaa gcggctccgg caccgagttc    300

accctgatcg tgtccagcct gcagcccgag gacttcgcca cctactactg cctgcagcac    360

cacagctacc ctctgaccag cggcggaggc accaaggtgg agatcaagcg gaccggcagc    420

accagcggca gcggcaagcc tggcagcggc gagggaagcg aggtccaggt gctggaatct    480

ggcggcggac tggtgcagcc tggcggcagc ctgagactga gctgtgccgc cagcggcttc    540

accttcagca gctacgccat gtcttgggtc cggcaggctc ctggaaaggg cctggaatgg    600

gtgtccgcca tcagcggctc tggcggctcc accaactacg ccgacagcgt gaagggccgg    660

ttcaccatca gccgggacaa cagcaagaac accctgtatc tgcagatgaa cagcctgaga    720

gccgaggaca ccgccgtgta ctactgtgcc ggcagcagcg ggtggagcga gtactggggc    780

cagggcacac tggtcacagt gtctagcgcg gccgcattcg tgccggtctt cctgccagcg    840

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag    900

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg    960

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc   1020

cttctcctgt cactggttat caccctttac tgcaaccaca ggaacaaacg gggcagaaag   1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa   1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa tcctactgcg tcgacttcga actcgagcga   1560

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1620

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1680

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1740

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1800

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1860

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1920

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1980

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   2040

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2100

ctgcgccttt tttagctatc gataagcttg gctgcaggtc gac                     2143


<210>  137
<211>  2133
<212>  DNA
<213>  Artificial

<220>
<223>  ￹EGFRvIIIǶϿԭͳĬϸ߼CBL-Bĺ
       EGFRvIII-CAR/iCBL-B

<400>  137
tctagagcta gcagatctat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     60

ctgctccacg ccgccaggcc gggatccgac atccagatga cccagagccc tagcagcctg    120

agcgccagcg tgggcgacag agtgaccatc acctgtcggg ccagccaggg catcagaaac    180

aacctggcct ggtatcagca gaagcccggc aaggccccca agagactgat ctacgctgcc    240

agcaatctgc agagcggcgt gcccagcaga ttcaccggaa gcggctccgg caccgagttc    300

accctgatcg tgtccagcct gcagcccgag gacttcgcca cctactactg cctgcagcac    360

cacagctacc ctctgaccag cggcggaggc accaaggtgg agatcaagcg gaccggcagc    420

accagcggca gcggcaagcc tggcagcggc gagggaagcg aggtccaggt gctggaatct    480

ggcggcggac tggtgcagcc tggcggcagc ctgagactga gctgtgccgc cagcggcttc    540

accttcagca gctacgccat gtcttgggtc cggcaggctc ctggaaaggg cctggaatgg    600

gtgtccgcca tcagcggctc tggcggctcc accaactacg ccgacagcgt gaagggccgg    660

ttcaccatca gccgggacaa cagcaagaac accctgtatc tgcagatgaa cagcctgaga    720

gccgaggaca ccgccgtgta ctactgtgcc ggcagcagcg ggtggagcga gtactggggc    780

cagggcacac tggtcacagt gtctagcgcg gccgcattcg tgccggtctt cctgccagcg    840

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag    900

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg    960

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc   1020

cttctcctgt cactggttat caccctttac tgcaaccaca ggaacaaacg gggcagaaag   1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa   1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa tcctactgcg tcgacttcga actcgagcga   1560

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1620

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1680

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1740

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1800

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1860

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1920

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1980

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   2040

gaaaggacga aacacctccc caacacagac gccatgattt gcttcaagag agcaaatcat   2100

ggcgtctgtg tttttttagc tgctagcgtc gac                                2133


<210>  138
<211>  2426
<212>  DNA
<213>  Artificial

<220>
<223>  ￹EGFRvIIIǶϿԭ塢Ĭϸ߼PD1ͳĬϸ
       ߼CBL-BĺӣEGFRvIII-CAR/iPD1- CBL-B

<400>  138
tctagagcta gcagatctat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     60

ctgctccacg ccgccaggcc gggatccgac atccagatga cccagagccc tagcagcctg    120

agcgccagcg tgggcgacag agtgaccatc acctgtcggg ccagccaggg catcagaaac    180

aacctggcct ggtatcagca gaagcccggc aaggccccca agagactgat ctacgctgcc    240

agcaatctgc agagcggcgt gcccagcaga ttcaccggaa gcggctccgg caccgagttc    300

accctgatcg tgtccagcct gcagcccgag gacttcgcca cctactactg cctgcagcac    360

cacagctacc ctctgaccag cggcggaggc accaaggtgg agatcaagcg gaccggcagc    420

accagcggca gcggcaagcc tggcagcggc gagggaagcg aggtccaggt gctggaatct    480

ggcggcggac tggtgcagcc tggcggcagc ctgagactga gctgtgccgc cagcggcttc    540

accttcagca gctacgccat gtcttgggtc cggcaggctc ctggaaaggg cctggaatgg    600

gtgtccgcca tcagcggctc tggcggctcc accaactacg ccgacagcgt gaagggccgg    660

ttcaccatca gccgggacaa cagcaagaac accctgtatc tgcagatgaa cagcctgaga    720

gccgaggaca ccgccgtgta ctactgtgcc ggcagcagcg ggtggagcga gtactggggc    780

cagggcacac tggtcacagt gtctagcgcg gccgcattcg tgccggtctt cctgccagcg    840

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag    900

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg    960

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc   1020

cttctcctgt cactggttat caccctttac tgcaaccaca ggaacaaacg gggcagaaag   1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa   1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa tcctactgcg tcgacttcga actcgagcga   1560

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1620

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1680

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1740

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1800

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1860

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1920

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1980

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   2040

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2100

ctgcgccttt tttagctatc gatatcgata gctaaaaaaa cacagacgcc atgatttgct   2160

ctcttgaagc aaatcatggc gtctgtgttg gggaagatct gtggtctcat acagaactta   2220

taagattccc aaatccaaag acatttcacg tttatggtga tttcccagaa cacatagcga   2280

catgcaaata ttgcagggcg ccactcccct gtccctcaca gccatcttcc tgccagggcg   2340

cacgcgcgct gggtgttccc gcctagtgac actgggcccg cgattccttg gagcgggttg   2400

atgacgtcag cgttcgaatt gtcgac                                        2426


<210>  139
<211>  2422
<212>  DNA
<213>  Artificial

<220>
<223>  ￹EGFRvIIIǶϿԭ塢Ĭϸ߼PD1ͳĬһ
       ϸ߼CTLA4ĺӣEGFRvIII-CAR/iPD1-CTLA4

<400>  139
tctagagcta gcagatctat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     60

ctgctccacg ccgccaggcc gggatccgac atccagatga cccagagccc tagcagcctg    120

agcgccagcg tgggcgacag agtgaccatc acctgtcggg ccagccaggg catcagaaac    180

aacctggcct ggtatcagca gaagcccggc aaggccccca agagactgat ctacgctgcc    240

agcaatctgc agagcggcgt gcccagcaga ttcaccggaa gcggctccgg caccgagttc    300

accctgatcg tgtccagcct gcagcccgag gacttcgcca cctactactg cctgcagcac    360

cacagctacc ctctgaccag cggcggaggc accaaggtgg agatcaagcg gaccggcagc    420

accagcggca gcggcaagcc tggcagcggc gagggaagcg aggtccaggt gctggaatct    480

ggcggcggac tggtgcagcc tggcggcagc ctgagactga gctgtgccgc cagcggcttc    540

accttcagca gctacgccat gtcttgggtc cggcaggctc ctggaaaggg cctggaatgg    600

gtgtccgcca tcagcggctc tggcggctcc accaactacg ccgacagcgt gaagggccgg    660

ttcaccatca gccgggacaa cagcaagaac accctgtatc tgcagatgaa cagcctgaga    720

gccgaggaca ccgccgtgta ctactgtgcc ggcagcagcg ggtggagcga gtactggggc    780

cagggcacac tggtcacagt gtctagcgcg gccgcattcg tgccggtctt cctgccagcg    840

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag    900

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg    960

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc   1020

cttctcctgt cactggttat caccctttac tgcaaccaca ggaacaaacg gggcagaaag   1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa   1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa tcctactgcg tcgacttcga actcgagcga   1560

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1620

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1680

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1740

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1800

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1860

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1920

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1980

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   2040

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2100

ctgcgccttt tttagctatc gatatcgata gctaaaaagc atcacttggg attaatatct   2160

cttgaatatt aatcccaagt gatgcgggga agatctgtgg tctcatacag aacttataag   2220

attcccaaat ccaaagacat ttcacgttta tggtgatttc ccagaacaca tagcgacatg   2280

caaatattgc agggcgccac tcccctgtcc ctcacagcca tcttcctgcc agggcgcacg   2340

cgcgctgggt gttcccgcct agtgacactg ggcccgcgat tccttggagc gggttgatga   2400

cgtcagcgtt cgaattgtcg ac                                            2422


