<110>  ϴѧ
 
<120>  һ֬øںϱԴױķ

<160>  20    

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  ˹

<400>  1
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  2
<211>  2085
<212>  DNA
<213>  ˹

<400>  2
gctccacctc aggctgctcc agctgataaa cctcaagttt tagcttcctt tacccaaact     60
tccgctagtt ctcagaatgc atggctggcc gcaaatcgta accaatctgc atgggccgct    120
tacgaatttg attggtcaac tgacttgtgt tcccaagctc cagataaccc attcggcttt    180
ccctttaaca cagcttgtgc taggcatgat ttcggttaca gaaattacaa ggcagccggt    240
tctttcgatg caaacaagtc acgaatcgac agtgccttct atgaagacat gaagagagtc    300
tgcactgggt ataccggaga gaaaaacact gcctgtaatt ctacagcctg gacgtattac    360
caggccgtga aaattcttgg tggtggtggt tctggtggtg gtggttcttt aggattgttt    420
agaggctcta gatacatgag agaacttcaa ctggcagcag agcttaacct agatcctaga    480
agtctttcta agaaaaacac agtccacagt gttctggcca aagctaacac tcagattgaa    540
aaagtgacca cagaatacat cacaatcccc atcgatcaca acgatacctc agttggaact    600
tatcagaaca gattttgggt taacgacgac tattacgaag ccggaagacc tatcatcatg    660
tacgatgcag gagaaaccaa tgctgaatct attgccaaga accatctaac ttcatcccta    720
tcctttttca gaaaaatatt ggaagacaca catgccatgg gtatcatttg ggaacataga    780
tactatggaa atagtacccc tttccccatt tctagagaca ctcctcccga acattttaag    840
tatctgacta ccaaacaggc cctggaagat attccctatt tcgctagaaa tttctcaaga    900
cctaaatttg ctgagcatga cttgacccca tcttcaaccc cttgggtctt ggttggtgga    960
tcatatgctg gtattagagc tgcatttgcc agaaataaat atccagacgt catttttgct   1020
gcatactctt catctgcccc agtacaagct cagttgaata tgtccatata ctatgatcaa   1080
gtctatagag gcttggtggg tcatggtttt gaaaactgcg ccaaggatat acacgctgct   1140
ctgggttaca ttgatcagca gttaagtaac aatcacacag cagccgctat taagaaattg   1200
ttctttggcc caggcgctga tcagaatagt aacgaaggtt ttactgctgc tctagctacc   1260
atttactcct actttcaaaa ttacggattg gatggtccag aaggaacttt gagagaatta   1320
tgtgaacatt tagaagtcga tccaactaca aaggaggctg ctggaccaga tggatttgca   1380
cctgtaagag gatcaaagca tgttgccgag agatgggcag catggccagc ttttacccca   1440
ttggttaaca acttcatgga gactaattgc agaggcttat ctgatcctgc taagccatct   1500
tgtaagcttg atatgacata ctacgacccc gactctatta gttggagttg gcagtattgt   1560
actgagtggg gtttctatca atcctccaat ttcggtcccc actcccttct ttccagatac   1620
caaaccctgg agtatcaaca agaggtttgt aataatcaat ttgctttggc agttgctaac   1680
ggtgtgttgc cttcataccc acaaactgaa gcactgaata aggagtatgg tggttggaac   1740
ataagaccta gtaatacatt cttcaccggt ggagagttcg atccatggag aacattgtcc   1800
atgcttacta ccgaggacat cgccccagag gtagcccctg acggtatcac tttctcaact   1860
aagattccta actgcggcga gacttccgag gataaagttt ttggttactt attgaaagat   1920
tccgagcact gttacgactt tcaaggttta tctactgaag gaaaggctgc cagagacctg   1980
ttcaaggaag ctctaacaaa atggttgcct tgtttcaagc catcatcttc taaagcttct   2040
atggtgaacg ttacacaagc cgaaattact aagggtgcag ttatg                   2085


<210>  3
<211>  126
<212>  PRT
<213>  ˹

<400>  3
Ala Pro Pro Gln Ala Ala Pro Ala Asp Lys Pro Gln Val Leu Ala Ser 
1               5                   10                  15      
Phe Thr Gln Thr Ser Ala Ser Ser Gln Asn Ala Trp Leu Ala Ala Asn 
            20                  25                  30          
Arg Asn Gln Ser Ala Trp Ala Ala Tyr Glu Phe Asp Trp Ser Thr Asp 
        35                  40                  45              
Leu Cys Ser Gln Ala Pro Asp Asn Pro Phe Gly Phe Pro Phe Asn Thr 
    50                  55                  60                  
Ala Cys Ala Arg His Asp Phe Gly Tyr Arg Asn Tyr Lys Ala Ala Gly 
65                  70                  75                  80  
Ser Phe Asp Ala Asn Lys Ser Arg Ile Asp Ser Ala Phe Tyr Glu Asp 
                85                  90                  95      
Met Lys Arg Val Cys Thr Gly Tyr Thr Gly Glu Lys Asn Thr Ala Cys 
            100                 105                 110         
Asn Ser Thr Ala Trp Thr Tyr Tyr Gln Ala Val Lys Ile Leu 
        115                 120                 125     


<210>  4
<211>  559
<212>  PRT
<213>  ˹

<400>  4
Leu Gly Leu Phe Arg Gly Ser Arg Tyr Met Arg Glu Leu Gln Leu Ala 
1               5                   10                  15      
Ala Glu Leu Asn Leu Asp Pro Arg Ser Leu Ser Lys Lys Asn Thr Val 
            20                  25                  30          
His Ser Val Leu Ala Lys Ala Asn Thr Gln Ile Glu Lys Val Thr Thr 
        35                  40                  45              
Glu Tyr Ile Thr Ile Pro Ile Asp His Asn Asp Thr Ser Val Gly Thr 
    50                  55                  60                  
Tyr Gln Asn Arg Phe Trp Val Asn Asp Asp Tyr Tyr Glu Ala Gly Arg 
65                  70                  75                  80  
Pro Ile Ile Met Tyr Asp Ala Gly Glu Thr Asn Ala Glu Ser Ile Ala 
                85                  90                  95      
Lys Asn His Leu Thr Ser Ser Leu Ser Phe Phe Arg Lys Ile Leu Glu 
            100                 105                 110         
Asp Thr His Ala Met Gly Ile Ile Trp Glu His Arg Tyr Tyr Gly Asn 
        115                 120                 125             
Ser Thr Pro Phe Pro Ile Ser Arg Asp Thr Pro Pro Glu His Phe Lys 
    130                 135                 140                 
Tyr Leu Thr Thr Lys Gln Ala Leu Glu Asp Ile Pro Tyr Phe Ala Arg 
145                 150                 155                 160 
Asn Phe Ser Arg Pro Lys Phe Ala Glu His Asp Leu Thr Pro Ser Ser 
                165                 170                 175     
Thr Pro Trp Val Leu Val Gly Gly Ser Tyr Ala Gly Ile Arg Ala Ala 
            180                 185                 190         
Phe Ala Arg Asn Lys Tyr Pro Asp Val Ile Phe Ala Ala Tyr Ser Ser 
        195                 200                 205             
Ser Ala Pro Val Gln Ala Gln Leu Asn Met Ser Ile Tyr Tyr Asp Gln 
    210                 215                 220                 
Val Tyr Arg Gly Leu Val Gly His Gly Phe Glu Asn Cys Ala Lys Asp 
225                 230                 235                 240 
Ile His Ala Ala Leu Gly Tyr Ile Asp Gln Gln Leu Ser Asn Asn His 
                245                 250                 255     
Thr Ala Ala Ala Ile Lys Lys Leu Phe Phe Gly Pro Gly Ala Asp Gln 
            260                 265                 270         
Asn Ser Asn Glu Gly Phe Thr Ala Ala Leu Ala Thr Ile Tyr Ser Tyr 
        275                 280                 285             
Phe Gln Asn Tyr Gly Leu Asp Gly Pro Glu Gly Thr Leu Arg Glu Leu 
    290                 295                 300                 
Cys Glu His Leu Glu Val Asp Pro Thr Thr Lys Glu Ala Ala Gly Pro 
305                 310                 315                 320 
Asp Gly Phe Ala Pro Val Arg Gly Ser Lys His Val Ala Glu Arg Trp 
                325                 330                 335     
Ala Ala Trp Pro Ala Phe Thr Pro Leu Val Asn Asn Phe Met Glu Thr 
            340                 345                 350         
Asn Cys Arg Gly Leu Ser Asp Pro Ala Lys Pro Ser Cys Lys Leu Asp 
        355                 360                 365             
Met Thr Tyr Tyr Asp Pro Asp Ser Ile Ser Trp Ser Trp Gln Tyr Cys 
    370                 375                 380                 
Thr Glu Trp Gly Phe Tyr Gln Ser Ser Asn Phe Gly Pro His Ser Leu 
385                 390                 395                 400 
Leu Ser Arg Tyr Gln Thr Leu Glu Tyr Gln Gln Glu Val Cys Asn Asn 
                405                 410                 415     
Gln Phe Ala Leu Ala Val Ala Asn Gly Val Leu Pro Ser Tyr Pro Gln 
            420                 425                 430         
Thr Glu Ala Leu Asn Lys Glu Tyr Gly Gly Trp Asn Ile Arg Pro Ser 
        435                 440                 445             
Asn Thr Phe Phe Thr Gly Gly Glu Phe Asp Pro Trp Arg Thr Leu Ser 
    450                 455                 460                 
Met Leu Thr Thr Glu Asp Ile Ala Pro Glu Val Ala Pro Asp Gly Ile 
465                 470                 475                 480 
Thr Phe Ser Thr Lys Ile Pro Asn Cys Gly Glu Thr Ser Glu Asp Lys 
                485                 490                 495     
Val Phe Gly Tyr Leu Leu Lys Asp Ser Glu His Cys Tyr Asp Phe Gln 
            500                 505                 510         
Gly Leu Ser Thr Glu Gly Lys Ala Ala Arg Asp Leu Phe Lys Glu Ala 
        515                 520                 525             
Leu Thr Lys Trp Leu Pro Cys Phe Lys Pro Ser Ser Ser Lys Ala Ser 
    530                 535                 540                 
Met Val Asn Val Thr Gln Ala Glu Ile Thr Lys Gly Ala Val Met 
545                 550                 555                 


<210>  5
<211>  376
<212>  PRT
<213>  ˹

<400>  5
Ala Ser Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
1               5                   10                  15      
Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
            20                  25                  30          
Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
        35                  40                  45              
Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
    50                  55                  60                  
Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
65                  70                  75                  80  
Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
                85                  90                  95      
Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
            100                 105                 110         
Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
        115                 120                 125             
Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
    130                 135                 140                 
Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
145                 150                 155                 160 
Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
                165                 170                 175     
Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
            180                 185                 190         
Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
        195                 200                 205             
Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
    210                 215                 220                 
Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
225                 230                 235                 240 
Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
                245                 250                 255     
Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
            260                 265                 270         
Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
        275                 280                 285             
Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
    290                 295                 300                 
Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
305                 310                 315                 320 
Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
                325                 330                 335     
Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
            340                 345                 350         
Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365             
Leu Ile Asn Gly Asp Gly Ala Gly 
    370                 375     


<210>  6
<211>  36
<212>  PRT
<213>  ˹

<400>  6
Gln Gln Thr Val Trp Gly Gln Cys Gly Gly Gln Gly Trp Ser Gly Pro 
1               5                   10                  15      
Thr Ser Cys Val Ala Gly Ser Ala Cys Ser Thr Leu Asn Pro Tyr Tyr 
            20                  25                  30          
Ala Gln Cys Ile 
        35      


<210>  7
<211>  105
<212>  PRT
<213>  ˹

<400>  7
Gly His His His His His His Gly Ser Leu Gln Glu Glu Lys Pro Lys 
1               5                   10                  15      
Glu Gly Val Lys Thr Glu Asn Asp His Ile Asn Leu Lys Val Ala Gly 
            20                  25                  30          
Gln Asp Gly Ser Val Val Gln Phe Lys Ile Lys Arg His Thr Pro Leu 
        35                  40                  45              
Ser Lys Leu Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met Arg 
    50                  55                  60                  
Gln Ile Arg Phe Arg Phe Asp Gly Gln Pro Ile Asn Glu Thr Asp Thr 
65                  70                  75                  80  
Pro Ala Gln Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln 
                85                  90                  95      
Gln Gln Thr Gly Gly Glu Phe Asp Pro 
            100                 105 


<210>  8
<211>  378
<212>  DNA
<213>  ˹

<400>  8
gctccacctc aggctgctcc agctgataaa cctcaagttt tagcttcctt tacccaaact     60
tccgctagtt ctcagaatgc atggctggcc gcaaatcgta accaatctgc atgggccgct    120
tacgaatttg attggtcaac tgacttgtgt tcccaagctc cagataaccc attcggcttt    180
ccctttaaca cagcttgtgc taggcatgat ttcggttaca gaaattacaa ggcagccggt    240
tctttcgatg caaacaagtc acgaatcgac agtgccttct atgaagacat gaagagagtc    300
tgcactgggt ataccggaga gaaaaacact gcctgtaatt ctacagcctg gacgtattac    360
caggccgtga aaattctt                                                  378


<210>  9
<211>  27
<212>  DNA
<213>  ˹

<400>  9
atcagaattc gctccacctc aggctgc                                         27


<210>  10
<211>  50
<212>  DNA
<213>  ˹

<400>  10
acaatcctaa agaaccacca ccaccagaac caccaccacc aagaattttc                50


<210>  11
<211>  27
<212>  DNA
<213>  ˹

<400>  11
agaattccag cagactgtct ggggaca                                         27


<210>  12
<211>  30
<212>  DNA
<213>  ˹

<400>  12
agaaccacca ccaccaatgc attgggcata                                      30


<210>  13
<211>  27
<212>  DNA
<213>  ˹

<400>  13
agaattcggt caccatcatc atcatca                                         27


<210>  14
<211>  30
<212>  DNA
<213>  ˹

<400>  14
agaaccacca ccaccgggat caaactcacc                                      30


<210>  15
<211>  27
<212>  DNA
<213>  ˹

<400>  15
agaattcgct agtaagatcg aagaagg                                         27


<210>  16
<211>  30
<212>  DNA
<213>  ˹

<400>  16
agaaccacca ccacctccag caccatcgcc                                      30


<210>  17
<211>  40
<212>  DNA
<213>  ˹

<400>  17
ggtggtggtg gttctggtgg tggtggttct ttaggattgt                           40


<210>  18
<211>  26
<212>  DNA
<213>  ˹

<400>  18
agcggccgcc ataactgcac ccttag                                          26


<210>  19
<211>  12
<212>  PRT
<213>  ˹

<400>  19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Arg 
1               5                   10          


<210>  20
<211>  15
<212>  PRT
<213>  ˹

<400>  20
Leu Glu Val Leu Phe Gln Gly Pro Glu Asn Leu Tyr Phe Gln Ser 
1               5                   10                  15  

