                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
       LYERLY, Herbert K.
       OSADA, Takuya
       HARTMAN, Zachary C.
 
<120>  CANCER VACCINES AND METHODS OF DELIVERY

<130>  5667-00376

<150>  US 62/275,952
<151>  2016-01-07

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(331)
<223>  Human HER3 Protein amino acid sequence

<400>  1

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe 
                325                 330     


<210>  2
<211>  1342
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1342)
<223>  Human HER3 Protein Precursor amino acid sequence

<400>  2

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Gly 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Gly Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  3
<211>  1239
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1239)
<223>  Homo sapiens HER2 polypeptide

<400>  3

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Pro Leu Thr Ser Ile Val Ser 
625                 630                 635                 640 


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
                645                 650                 655     


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
            660                 665                 670         


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
        675                 680                 685             


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
    690                 695                 700                 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
705                 710                 715                 720 


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
                725                 730                 735     


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
            740                 745                 750         


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
        755                 760                 765             


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
    770                 775                 780                 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
785                 790                 795                 800 


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
                805                 810                 815     


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
            820                 825                 830         


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
        835                 840                 845             


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
    850                 855                 860                 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
865                 870                 875                 880 


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
                885                 890                 895     


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
            900                 905                 910         


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
        915                 920                 925             


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
    930                 935                 940                 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
945                 950                 955                 960 


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
                965                 970                 975     


Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu 
            980                 985                 990         


Leu Glu Asp Asp Asp Met Gly Asp  Leu Val Asp Ala Glu  Glu Tyr Leu 
        995                 1000                 1005             


Val Pro  Gln Gln Gly Phe Phe  Cys Pro Asp Pro Ala  Pro Gly Ala 
    1010                 1015                 1020             


Gly Gly  Met Val His His Arg  His Arg Ser Ser Ser  Thr Arg Ser 
    1025                 1030                 1035             


Gly Gly  Gly Asp Leu Thr Leu  Gly Leu Glu Pro Ser  Glu Glu Glu 
    1040                 1045                 1050             


Ala Pro  Arg Ser Pro Leu Ala  Pro Ser Glu Gly Ala  Gly Ser Asp 
    1055                 1060                 1065             


Val Phe  Asp Gly Asp Leu Gly  Met Gly Ala Ala Lys  Gly Leu Gln 
    1070                 1075                 1080             


Ser Leu  Pro Thr His Asp Pro  Ser Pro Leu Gln Arg  Tyr Ser Glu 
    1085                 1090                 1095             


Asp Pro  Thr Val Pro Leu Pro  Ser Glu Thr Asp Gly  Tyr Val Ala 
    1100                 1105                 1110             


Pro Leu  Thr Cys Ser Pro Gln  Pro Glu Tyr Val Asn  Gln Pro Asp 
    1115                 1120                 1125             


Val Arg  Pro Gln Pro Pro Ser  Pro Arg Glu Gly Pro  Leu Pro Ala 
    1130                 1135                 1140             


Ala Arg  Pro Ala Gly Ala Thr  Leu Glu Arg Ala Lys  Thr Leu Ser 
    1145                 1150                 1155             


Pro Gly  Lys Asn Gly Val Val  Lys Asp Val Phe Ala  Phe Gly Gly 
    1160                 1165                 1170             


Ala Val  Glu Asn Pro Glu Tyr  Leu Thr Pro Gln Gly  Gly Ala Ala 
    1175                 1180                 1185             


Pro Gln  Pro His Pro Pro Pro  Ala Phe Ser Pro Ala  Phe Asp Asn 
    1190                 1195                 1200             


Leu Tyr  Tyr Trp Asp Gln Asp  Pro Pro Glu Arg Gly  Ala Pro Pro 
    1205                 1210                 1215             


Ser Thr  Phe Lys Gly Thr Pro  Thr Ala Glu Asn Pro  Glu Tyr Leu 
    1220                 1225                 1230             


Gly Leu  Asp Val Pro Val 
    1235                 


<210>  4
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  Homo sapiens HER2 polypeptide

<400>  4

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
            100                 105                 110     


<210>  5
<211>  668
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(668)
<223>  Homo sapiens HER2 polypeptide

<400>  5

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Pro Leu Thr Ser Ile Val Ser 
625                 630                 635                 640 


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
                645                 650                 655     


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys 
            660                 665             


<210>  6
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens ESR1 polypeptide

<400>  6

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Asn Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  7
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens ESR1 polypeptide

<400>  7

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Ser Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  8
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens ESR1 polypeptide

<400>  8

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Gly Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  9
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens ESR1 polypeptide

<400>  9

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Arg Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  10
<211>  315
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(315)
<223>  Lactadherin C1C2

<400>  10

Ser Thr Gln Leu Gly Met Glu Gly Gly Ala Ile Ala Asp Ser Gln Ile 
1               5                   10                  15      


Ser Ala Ser Ser Val Tyr Met Gly Phe Met Gly Leu Gln Arg Trp Gly 
            20                  25                  30          


Pro Glu Leu Ala Arg Leu Tyr Arg Thr Gly Ile Val Asn Ala Trp Thr 
        35                  40                  45              


Ala Ser Asn Tyr Asp Ser Lys Pro Trp Ile Gln Val Asn Leu Leu Arg 
    50                  55                  60                  


Lys Met Arg Val Ser Gly Val Met Thr Gln Gly Ala Ser Arg Ala Gly 
65                  70                  75                  80  


Arg Ala Glu Tyr Leu Lys Thr Phe Lys Val Ala Tyr Ser Leu Asp Gly 
                85                  90                  95      


Arg Lys Phe Glu Phe Ile Gln Asp Glu Ser Gly Gly Asp Lys Glu Phe 
            100                 105                 110         


Leu Gly Asn Leu Asp Asn Asn Ser Leu Lys Val Asn Met Phe Asn Pro 
        115                 120                 125             


Thr Leu Glu Ala Gln Tyr Ile Lys Leu Tyr Pro Val Ser Cys His Arg 
    130                 135                 140                 


Gly Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu His Gly Cys 
145                 150                 155                 160 


Ser Glu Pro Leu Gly Leu Lys Asn Asn Thr Ile Pro Asp Ser Gln Met 
                165                 170                 175     


Ser Ala Ser Ser Ser Tyr Lys Thr Trp Asn Leu Arg Ala Phe Gly Trp 
            180                 185                 190         


Tyr Pro His Leu Gly Arg Leu Asp Asn Gln Gly Lys Ile Asn Ala Trp 
        195                 200                 205             


Thr Ala Gln Ser Asn Ser Ala Lys Glu Trp Leu Gln Val Asp Leu Gly 
    210                 215                 220                 


Thr Gln Arg Gln Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asp Phe 
225                 230                 235                 240 


Gly His Ile Gln Tyr Val Ala Ser Tyr Lys Val Ala His Ser Asp Asp 
                245                 250                 255     


Gly Val Gln Trp Thr Val Tyr Glu Glu Gln Gly Ser Ser Lys Val Phe 
            260                 265                 270         


Gln Gly Asn Leu Asp Asn Asn Ser His Lys Lys Asn Ile Phe Glu Lys 
        275                 280                 285             


Pro Phe Met Ala Arg Tyr Val Arg Val Leu Pro Val Ser Trp His Asn 
    290                 295                 300                 


Arg Ile Thr Leu Arg Leu Glu Leu Leu Gly Cys 
305                 310                 315 


<210>  11
<211>  2880
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2880)
<223>  DNA sequence of Human Her3ECDC1C2

<400>  11
accatgaggg cgaacgacgc tctgcaggtg ctgggcttgc ttttcagcct ggcccggggc       60

tccgaggtgg gcaactctca ggcagtgtgt cctgggactc tgaatggcct gagtgtgacc      120

ggcgatgctg agaaccaata ccagacactg tacaagctct acgagaggtg tgaggtggtg      180

atggggaacc ttgagattgt gctcacggga cacaatgccg acctctcctt cctgcagtgg      240

attcgagaag tgacaggcta tgtcctcgtg gccatgaatg aattctctac tctaccattg      300

cccaacctcc gcgtggtgcg agggacccag gtctacgatg ggaagtttgc catcttcgtc      360

atgttgaact ataacaccaa ctccagccac gctctgcgcc agctccgctt gactcagctc      420

accgagattc tgtcaggggg tgtttatatt gagaagaacg ataagctttg tcacatggac      480

acaattgact ggagggacat cgtgagggac cgagatgctg agatagtggt gaaggacaat      540

ggcagaagct gtcccccctg tcatgaggtt tgcaaggggc gatgctgggg tcctggatca      600

gaagactgcc agacattgac caagaccatc tgtgctcctc agtgtaatgg tcactgcttt      660

gggcccaacc ccaaccagtg ctgccatgat gagtgtgccg ggggctgctc aggccctcag      720

gacacagact gctttgcctg ccggcacttc aatgacagtg gagcctgtgt acctcgctgt      780

ccacagcctc ttgtctacaa caagctaact ttccagctgg aacccaatcc ccacaccaag      840

tatcagtatg gaggagtttg tgtagccagc tgtccccata actttgtggt ggatcaaaca      900

tcctgtgtca gggcctgtcc tcctgacaag atggaagtag ataaaaatgg gctcaagatg      960

tgtgagcctt gtgggggact atgtcccaaa gcctgtgagg gaacaggctc tgggagccgc     1020

ttccagactg tggactcgag caacattgat ggatttgtga actgcaccaa gatcctgggc     1080

aacctggact ttctgatcac cggcctcaat ggagacccct ggcacaagat ccctgccctg     1140

gacccagaga agctcaatgt cttccggaca gtacgggaga tcacaggtta cctgaacatc     1200

cagtcctggc cgccccacat gcacaacttc agtgtttttt ccaatttgac aaccattgga     1260

ggcagaagcc tctacaaccg gggcttctca ttgttgatca tgaagaactt gaatgtcaca     1320

tctctgggct tccgatccct gaaggaaatt agtgctgggc gtatctatat aagtgccaat     1380

aggcagctct gctaccacca ctctttgaac tggaccaagg tgcttcgggg gcctacggaa     1440

gagcgactag acatcaagca taatcggccg cgcagagact gcgtggcaga gggcaaagtg     1500

tgtgacccac tgtgctcctc tgggggatgc tggggcccag gccctggtca gtgcttgtcc     1560

tgtcgaaatt atagccgagg aggtgtctgt gtgacccact gcaactttct gaatggggag     1620

cctcgagaat ttgcccatga ggccgaatgc ttctcctgcc acccggaatg ccaacccatg     1680

gagggcactg ccacatgcaa tggctcgggc tctgatactt gtgctcaatg tgcccatttt     1740

cgagatgggc cccactgtgt gagcagctgc ccccatggag tcctaggtgc caagggccca     1800

atctacaagt acccagatgt tcagaatgaa tgtcggccct gccatgagaa ctgcacccag     1860

gggtgtaaag gaccagagct tcaagactgt ttaggacaaa cactggtgct gatcggcaaa     1920

acccatctga catctacaca gctgggcatg gaagggggcg ccattgctga ttcacagatt     1980

tccgcctcgt ctgtgtatat gggtttcatg ggcttgcagc gctggggccc ggagctggct     2040

cgtctgtacc gcacagggat cgtcaatgcc tggacagcca gcaactatga tagcaagccc     2100

tggatccagg tgaaccttct gcggaagatg cgggtatcag gtgtgatgac gcagggtgcc     2160

agccgtgccg ggagggcgga gtacctgaag accttcaagg tggcttacag cctcgacgga     2220

cgcaagtttg agttcatcca ggatgaaagc ggtggagaca aggagttttt gggtaacctg     2280

gacaacaaca gcctgaaggt taacatgttc aacccgactc tggaggcaca gtacataaag     2340

ctgtaccctg tttcgtgcca ccgcggctgc accctccgct tcgagctcct gggctgtgag     2400

ttgcacggat gttctgagcc cctgggcctg aagaataaca caattcctga cagccagatg     2460

tcagcctcca gcagctacaa gacatggaac ctgcgtgctt ttggctggta cccccacttg     2520

ggaaggctgg ataatcaggg caagatcaat gcctggacgg ctcagagcaa cagtgccaag     2580

gaatggctgc aggttgacct gggcactcag aggcaagtga caggaatcat cacccagggg     2640

gcccgtgact ttggccacat ccagtatgtg gcgtcctaca aggtagccca cagtgatgat     2700

ggtgtgcagt ggactgtata tgaggagcaa ggaagcagca aggtcttcca gggcaacttg     2760

gacaacaact cccacaagaa gaacatcttc gagaaaccct tcatggctcg ctacgtgcgt     2820

gtccttccag tgtcctggca taaccgcatc accctgcgcc tggagctgct gggctgttaa     2880


<210>  12
<211>  958
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(958)
<223>  HER3C1C2-lactadherin  protein (polypeptide) sequence

<400>  12

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Ser Thr Gln Leu Gly Met Glu Gly Gly Ala Ile Ala Asp 
                645                 650                 655     


Ser Gln Ile Ser Ala Ser Ser Val Tyr Met Gly Phe Met Gly Leu Gln 
            660                 665                 670         


Arg Trp Gly Pro Glu Leu Ala Arg Leu Tyr Arg Thr Gly Ile Val Asn 
        675                 680                 685             


Ala Trp Thr Ala Ser Asn Tyr Asp Ser Lys Pro Trp Ile Gln Val Asn 
    690                 695                 700                 


Leu Leu Arg Lys Met Arg Val Ser Gly Val Met Thr Gln Gly Ala Ser 
705                 710                 715                 720 


Arg Ala Gly Arg Ala Glu Tyr Leu Lys Thr Phe Lys Val Ala Tyr Ser 
                725                 730                 735     


Leu Asp Gly Arg Lys Phe Glu Phe Ile Gln Asp Glu Ser Gly Gly Asp 
            740                 745                 750         


Lys Glu Phe Leu Gly Asn Leu Asp Asn Asn Ser Leu Lys Val Asn Met 
        755                 760                 765             


Phe Asn Pro Thr Leu Glu Ala Gln Tyr Ile Lys Leu Tyr Pro Val Ser 
    770                 775                 780                 


Cys His Arg Gly Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu 
785                 790                 795                 800 


His Gly Cys Ser Glu Pro Leu Gly Leu Lys Asn Asn Thr Ile Pro Asp 
                805                 810                 815     


Ser Gln Met Ser Ala Ser Ser Ser Tyr Lys Thr Trp Asn Leu Arg Ala 
            820                 825                 830         


Phe Gly Trp Tyr Pro His Leu Gly Arg Leu Asp Asn Gln Gly Lys Ile 
        835                 840                 845             


Asn Ala Trp Thr Ala Gln Ser Asn Ser Ala Lys Glu Trp Leu Gln Val 
    850                 855                 860                 


Asp Leu Gly Thr Gln Arg Gln Val Thr Gly Ile Ile Thr Gln Gly Ala 
865                 870                 875                 880 


Arg Asp Phe Gly His Ile Gln Tyr Val Ala Ser Tyr Lys Val Ala His 
                885                 890                 895     


Ser Asp Asp Gly Val Gln Trp Thr Val Tyr Glu Glu Gln Gly Ser Ser 
            900                 905                 910         


Lys Val Phe Gln Gly Asn Leu Asp Asn Asn Ser His Lys Lys Asn Ile 
        915                 920                 925             


Phe Glu Lys Pro Phe Met Ala Arg Tyr Val Arg Val Leu Pro Val Ser 
    930                 935                 940                 


Trp His Asn Arg Ile Thr Leu Arg Leu Glu Leu Leu Gly Cys 
945                 950                 955             


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  13

Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr 
1               5                   10      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  14

Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp Arg Asp Ile Val 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  15

Pro Cys His Glu Val Cys Lys 
1               5           


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  16

Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro 
1               5                   10                  15  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  17

Asn Gly Asp Pro Trp His Lys 
1               5           


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  18

Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  19

Cys Pro His Gly Val Leu Gly Ala Lys Gly Pro 
1               5                   10      


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  20

Ile Ala Gly Leu Val Val Ile Phe Met Met Leu Gly Gly Thr Phe 
1               5                   10                  15  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  21

Leu Glu Arg Gly Glu Ser Ile Glu Pro Leu Asp 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  22

Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile 
1               5                   10      


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  23

Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  24

Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu 
1               5                   10                  15  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  25

Glu Ser Gly Pro Gly Ile Ala Pro 
1               5               


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  26

Thr Leu Asn Arg Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  27

Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser 
1               5                   10                  15  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  28

Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  29

Met Pro Thr Ala Gly Thr Thr 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide derived from HER3 protein sequence

<400>  30

Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met 
1               5                   10          


<210>  31
<211>  3720
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3720)
<223>  Homo sapiens HER2 polynucleotide

<400>  31
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactccc ctctgacgtc catcgtctct     1920

gcggtggttg gcattctgct ggtcgtggtc ttgggggtgg tctttgggat cctcatcaag     1980

cgacggcagc agaagatccg gaagtacacg atgcggagac tgctgcagga aacggagctg     2040

gtggagccgc tgacacctag cggagcgatg cccaaccagg cgcagatgcg gatcctgaaa     2100

gagacggagc tgaggaaggt gaaggtgctt ggatctggcg cttttggcac agtctacaag     2160

ggcatctgga tccctgatgg ggagaatgtg aaaattccag tggccatcaa agtgttgagg     2220

gaaaacacat cccccaaagc caacaaagaa atcttagacg aagcatacgt gatggctggt     2280

gtgggctccc catatgtctc ccgccttctg gggatctgcc tgacatccac ggtgcagctg     2340

gtgacacagc ttatgcccta tggctgcctc ttagaccatg tccgggaaaa ccgcggacgc     2400

ctgggctccc aggacctgct gaactggtgt atgcagattg ccaaggggat gagctacctg     2460

gaggatgtgc ggctcgtaca cagggacttg gccgctcgga acgtgctggt caagagtccc     2520

aaccatgtca aaattacaga cttcgggctg gctcggctgc tggacattga cgagacagag     2580

taccatgcag atgggggcaa ggtgcccatc aagtggatgg cgctggagtc cattctccgc     2640

cggcggttca cccaccagag tgatgtgtgg agttatggtg tgactgtgtg ggagctgatg     2700

acttttgggg ccaaacctta cgatgggatc ccagcccggg agatccctga cctgctggaa     2760

aagggggagc ggctgcccca gccccccatc tgcaccattg atgtctacat gatcatggtc     2820

aaatgttgga tgattgactc tgaatgtcgg ccaagattcc gggagttggt gtctgaattc     2880

tcccgcatgg ccagggaccc ccagcgcttt gtggtcatcc agaatgagga cttgggccca     2940

gccagtccct tggacagcac cttctaccgc tcactgctgg aggacgatga catgggggac     3000

ctggtggatg ctgaggagta tctggtaccc cagcagggct tcttctgtcc agaccctgcc     3060

ccgggcgctg ggggcatggt ccaccacagg caccgcagct catctaccag gagtggcggt     3120

ggggacctga cactagggct ggagccctct gaagaggagg cccccaggtc tccactggca     3180

ccctccgaag gggctggctc cgatgtattt gatggtgacc tgggaatggg ggcagccaag     3240

gggctgcaaa gcctccccac acatgacccc agccctctac agcggtacag tgaggacccc     3300

acagtacccc tgccctctga gactgatggc tacgttgccc ccctgacctg cagcccccag     3360

cctgaatatg tgaaccagcc agatgttcgg ccccagcccc cttcgccccg agagggccct     3420

ctgcctgctg cccgacctgc tggtgccact ctggaaaggg ccaagactct ctccccaggg     3480

aagaatgggg tcgtcaaaga cgtttttgcc tttgggggtg ccgtggagaa ccccgagtac     3540

ttgacacccc agggaggagc tgcccctcag ccccaccctc ctcctgcctt cagcccagcc     3600

ttcgacaacc tctattactg ggaccaggac ccaccagagc ggggggctcc acccagcacc     3660

ttcaaaggga cacctacggc agagaaccca gagtacctgg gtctggacgt gccagtgtga     3720


<210>  32
<211>  335
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(335)
<223>  Homo sapiens HER2 polynucleotide

<400>  32
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aacta                                 335


<210>  33
<211>  3720
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3720)
<223>  Homo sapiens HER2 polynucleotide

<400>  33
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactccc ctctgacgtc catcgtctct     1920

gcggtggttg gcattctgct ggtcgtggtc ttgggggtgg tctttgggat cctcatcaag     1980

cgacggcagc agaagatccg gaagtagacg atgcggagac tgctgcagga aacggagctg     2040

gtggagccgc tgacacctag cggagcgatg cccaaccagg cgcagatgcg gatcctgaaa     2100

gagacggagc tgaggaaggt gaaggtgctt ggatctggcg cttttggcac agtctacaag     2160

ggcatctgga tccctgatgg ggagaatgtg aaaattccag tggccatcaa agtgttgagg     2220

gaaaacacat cccccaaagc caacaaagaa atcttagacg aagcatacgt gatggctggt     2280

gtgggctccc catatgtctc ccgccttctg gggatctgcc tgacatccac ggtgcagctg     2340

gtgacacagc ttatgcccta tggctgcctc ttagaccatg tccgggaaaa ccgcggacgc     2400

ctgggctccc aggacctgct gaactggtgt atgcagattg ccaaggggat gagctacctg     2460

gaggatgtgc ggctcgtaca cagggacttg gccgctcgga acgtgctggt caagagtccc     2520

aaccatgtca aaattacaga cttcgggctg gctcggctgc tggacattga cgagacagag     2580

taccatgcag atgggggcaa ggtgcccatc aagtggatgg cgctggagtc cattctccgc     2640

cggcggttca cccaccagag tgatgtgtgg agttatggtg tgactgtgtg ggagctgatg     2700

acttttgggg ccaaacctta cgatgggatc ccagcccggg agatccctga cctgctggaa     2760

aagggggagc ggctgcccca gccccccatc tgcaccattg atgtctacat gatcatggtc     2820

aaatgttgga tgattgactc tgaatgtcgg ccaagattcc gggagttggt gtctgaattc     2880

tcccgcatgg ccagggaccc ccagcgcttt gtggtcatcc agaatgagga cttgggccca     2940

gccagtccct tggacagcac cttctaccgc tcactgctgg aggacgatga catgggggac     3000

ctggtggatg ctgaggagta tctggtaccc cagcagggct tcttctgtcc agaccctgcc     3060

ccgggcgctg ggggcatggt ccaccacagg caccgcagct catctaccag gagtggcggt     3120

ggggacctga cactagggct ggagccctct gaagaggagg cccccaggtc tccactggca     3180

ccctccgaag gggctggctc cgatgtattt gatggtgacc tgggaatggg ggcagccaag     3240

gggctgcaaa gcctccccac acatgacccc agccctctac agcggtacag tgaggacccc     3300

acagtacccc tgccctctga gactgatggc tacgttgccc ccctgacctg cagcccccag     3360

cctgaatatg tgaaccagcc agatgttcgg ccccagcccc cttcgccccg agagggccct     3420

ctgcctgctg cccgacctgc tggtgccact ctggaaaggg ccaagactct ctccccaggg     3480

aagaatgggg tcgtcaaaga cgtttttgcc tttgggggtg ccgtggagaa ccccgagtac     3540

ttgacacccc agggaggagc tgcccctcag ccccaccctc ctcctgcctt cagcccagcc     3600

ttcgacaacc tctattactg ggaccaggac ccaccagagc ggggggctcc acccagcacc     3660

ttcaaaggga cacctacggc agagaaccca gagtacctgg gtctggacgt gccagtgtga     3720


<210>  34
<211>  331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(331)
<223>  Homo sapiens HER2 polypeptide

<400>  34

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe 
                325                 330     


<210>  35
<211>  1342
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1342)
<223>  Homo sapiens HER2 polypeptide

<400>  35

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Gly 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Gly Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  36
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens HER2 polypeptide

<400>  36

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Asn Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  37
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens HER2 polypeptide

<400>  37

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Ser Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  38
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens HER polypeptide

<400>  38

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Gly Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  39
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Homo sapiens HER2 polypeptide

<400>  39

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Arg Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  40
<211>  1239
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1239)
<223>  Homo sapiens ESR1 polypeptide

<400>  40

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Pro Leu Thr Ser Ile Val Ser 
625                 630                 635                 640 


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
                645                 650                 655     


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
            660                 665                 670         


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
        675                 680                 685             


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
    690                 695                 700                 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
705                 710                 715                 720 


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
                725                 730                 735     


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
            740                 745                 750         


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
        755                 760                 765             


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
    770                 775                 780                 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
785                 790                 795                 800 


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
                805                 810                 815     


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
            820                 825                 830         


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
        835                 840                 845             


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
    850                 855                 860                 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
865                 870                 875                 880 


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
                885                 890                 895     


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
            900                 905                 910         


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
        915                 920                 925             


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
    930                 935                 940                 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
945                 950                 955                 960 


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
                965                 970                 975     


Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu 
            980                 985                 990         


Leu Glu Asp Asp Asp Met Gly Asp  Leu Val Asp Ala Glu  Glu Tyr Leu 
        995                 1000                 1005             


Val Pro  Gln Gln Gly Phe Phe  Cys Pro Asp Pro Ala  Pro Gly Ala 
    1010                 1015                 1020             


Gly Gly  Met Val His His Arg  His Arg Ser Ser Ser  Thr Arg Ser 
    1025                 1030                 1035             


Gly Gly  Gly Asp Leu Thr Leu  Gly Leu Glu Pro Ser  Glu Glu Glu 
    1040                 1045                 1050             


Ala Pro  Arg Ser Pro Leu Ala  Pro Ser Glu Gly Ala  Gly Ser Asp 
    1055                 1060                 1065             


Val Phe  Asp Gly Asp Leu Gly  Met Gly Ala Ala Lys  Gly Leu Gln 
    1070                 1075                 1080             


Ser Leu  Pro Thr His Asp Pro  Ser Pro Leu Gln Arg  Tyr Ser Glu 
    1085                 1090                 1095             


Asp Pro  Thr Val Pro Leu Pro  Ser Glu Thr Asp Gly  Tyr Val Ala 
    1100                 1105                 1110             


Pro Leu  Thr Cys Ser Pro Gln  Pro Glu Tyr Val Asn  Gln Pro Asp 
    1115                 1120                 1125             


Val Arg  Pro Gln Pro Pro Ser  Pro Arg Glu Gly Pro  Leu Pro Ala 
    1130                 1135                 1140             


Ala Arg  Pro Ala Gly Ala Thr  Leu Glu Arg Ala Lys  Thr Leu Ser 
    1145                 1150                 1155             


Pro Gly  Lys Asn Gly Val Val  Lys Asp Val Phe Ala  Phe Gly Gly 
    1160                 1165                 1170             


Ala Val  Glu Asn Pro Glu Tyr  Leu Thr Pro Gln Gly  Gly Ala Ala 
    1175                 1180                 1185             


Pro Gln  Pro His Pro Pro Pro  Ala Phe Ser Pro Ala  Phe Asp Asn 
    1190                 1195                 1200             


Leu Tyr  Tyr Trp Asp Gln Asp  Pro Pro Glu Arg Gly  Ala Pro Pro 
    1205                 1210                 1215             


Ser Thr  Phe Lys Gly Thr Pro  Thr Ala Glu Asn Pro  Glu Tyr Leu 
    1220                 1225                 1230             


Gly Leu  Asp Val Pro Val 
    1235                 


<210>  41
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  Homo sapiens ESR1 polypeptide

<400>  41

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
            100                 105                 110     


<210>  42
<211>  668
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(668)
<223>  Homo sapiens ESR1 polypeptide

<400>  42

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Pro Leu Thr Ser Ile Val Ser 
625                 630                 635                 640 


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
                645                 650                 655     


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys 
            660                 665             


<210>  43
<211>  331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(331)
<223>  Homo sapiens ESR1 polypeptide

<400>  43

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe 
                325                 330     


<210>  44
<211>  1342
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1342)
<223>  Homo sapiens ESR1 polypeptide

<400>  44

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Gly 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Gly Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


