                         SEQUENCE LISTING

<110>  The Schepens Eye Research Institute, Inc.
 
<120>  THERAPEUTICS FOR OCULAR IMMUNOINFLAMMATORY DISEASES

<130>  36770-547001WO

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             


Gly Thr Lys Glu His 
    130             


<210>  3
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
1               5                   10                  15      


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys Ser Leu Lys 
            20                  25                  30          


Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln 
        35                  40                  45              


Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
    50                  55                  60                  


<210>  4
<211>  2089
<212>  DNA
<213>  Homo sapiens

<400>  4
acatccgcgg caacgcctcc ttggtgtcgt ccgcttccaa taacccagct tgcgtcctgc       60

acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc      120

gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag      180

gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag      240

gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc      300

caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat      360

cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc      420

ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc      480

ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc      540

ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac      600

catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt      660

gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt      720

tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct      780

gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg aaggtatgtt      840

tttattccgt gctgctcgca agttgaggca atttcttaaa atgaatagca ctggtgattt      900

tgatctccac ttattaaaag tttcagaagg cacaacaata ctgttgaact gcactggcca      960

ggttaaagga agaaaaccag ctgccctggg tgaagcccaa ccaacaaaga gtttggaaga     1020

aaataaatct ttaaaggaac agaaaaaact gaatgacttg tgtttcctaa agagactatt     1080

acaagagata aaaacttgtt ggaataaaat tttgatgggc actaaagaac actgaaaaat     1140

atggagtggc aatatagaaa cacgaacttt agctgcatcc tccaagaatc tatctgctta     1200

tgcagttttt cagagtggaa tgcttcctag aagttactga atgcaccatg gtcaaaacgg     1260

attagggcat ttgagaaatg catattgtat tactagaaga tgaatacaaa caatggaaac     1320

tgaatgctcc agtcaacaaa ctatttctta tatatgtgaa catttatcaa tcagtataat     1380

tctgtactga tttttgtaag acaatccatg taaggtatca gttgcaataa tacttctcaa     1440

acctgtttaa atatttcaag acattaaatc tatgaagtat ataatggttt caaagattca     1500

aaattgacat tgctttactg tcaaaataat tttatggctc actatgaatc tattatactg     1560

tattaagagt gaaaattgtc ttcttctgtg ctggagatgt tttagagtta acaatgatat     1620

atggataatg ccggtgagaa taagagagtc ataaacctta agtaagcaac agcataacaa     1680

ggtccaagat acctaaaaga gatttcaaga gatttaatta atcatgaatg tgtaacacag     1740

tgccttcaat aaatggtata gcaaatgttt tgacatgaaa aaaggacaat ttcaaaaaaa     1800

taaaataaaa taaaaataaa ttcacctagt ctaaggatgc taaaccttag tactgagtta     1860

cattgtcatt tatatagatt ataacttgtc taaataagtt tgcaatttgg gagatatatt     1920

tttaagataa taatatatgt ttacctttta attaatgaaa tatctgtatt taattttgac     1980

actatatctg tatataaaat attttcatac agcattacaa attgcttact ttggaataca     2040

tttctccttt gataaaataa atgagctatg tattaaaaaa aaaaaaaaa                 2089


<210>  5
<211>  1957
<212>  DNA
<213>  Homo sapiens

<400>  5
acatccgcgg caacgcctcc ttggtgtcgt ccgcttccaa taacccagct tgcgtcctgc       60

acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc      120

gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag      180

gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag      240

gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc      300

caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat      360

cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc      420

ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc      480

ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc      540

ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac      600

catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt      660

gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt      720

tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct      780

gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg ttaaaggaag      840

aaaaccagct gccctgggtg aagcccaacc aacaaagagt ttggaagaaa ataaatcttt      900

aaaggaacag aaaaaactga atgacttgtg tttcctaaag agactattac aagagataaa      960

aacttgttgg aataaaattt tgatgggcac taaagaacac tgaaaaatat ggagtggcaa     1020

tatagaaaca cgaactttag ctgcatcctc caagaatcta tctgcttatg cagtttttca     1080

gagtggaatg cttcctagaa gttactgaat gcaccatggt caaaacggat tagggcattt     1140

gagaaatgca tattgtatta ctagaagatg aatacaaaca atggaaactg aatgctccag     1200

tcaacaaact atttcttata tatgtgaaca tttatcaatc agtataattc tgtactgatt     1260

tttgtaagac aatccatgta aggtatcagt tgcaataata cttctcaaac ctgtttaaat     1320

atttcaagac attaaatcta tgaagtatat aatggtttca aagattcaaa attgacattg     1380

ctttactgtc aaaataattt tatggctcac tatgaatcta ttatactgta ttaagagtga     1440

aaattgtctt cttctgtgct ggagatgttt tagagttaac aatgatatat ggataatgcc     1500

ggtgagaata agagagtcat aaaccttaag taagcaacag cataacaagg tccaagatac     1560

ctaaaagaga tttcaagaga tttaattaat catgaatgtg taacacagtg ccttcaataa     1620

atggtatagc aaatgttttg acatgaaaaa aggacaattt caaaaaaata aaataaaata     1680

aaaataaatt cacctagtct aaggatgcta aaccttagta ctgagttaca ttgtcattta     1740

tatagattat aacttgtcta aataagtttg caatttggga gatatatttt taagataata     1800

atatatgttt accttttaat taatgaaata tctgtattta attttgacac tatatctgta     1860

tataaaatat tttcatacag cattacaaat tgcttacttt ggaatacatt tctcctttga     1920

taaaataaat gagctatgta ttaaaaaaaa aaaaaaa                              1957


<210>  6
<211>  2035
<212>  DNA
<213>  Homo sapiens

<400>  6
acatccgcgg caacgcctcc ttggtgtcgt ccgcttccaa taacccagct tgcgtcctgc       60

acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc      120

gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag      180

gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag      240

gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc      300

caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat      360

cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc      420

ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc      480

ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc      540

ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac      600

catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt      660

gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt      720

tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct      780

gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg aaggtatgtt      840

tttattccgt gctgctcgca agttgaggca atttcttaaa atgaatagca ctggtgattt      900

tgatctccac ttattaaaag tttcagaagg cacaacaata ctgttgaact gcactggcca      960

ggaagaaaat aaatctttaa aggaacagaa aaaactgaat gacttgtgtt tcctaaagag     1020

actattacaa gagataaaaa cttgttggaa taaaattttg atgggcacta aagaacactg     1080

aaaaatatgg agtggcaata tagaaacacg aactttagct gcatcctcca agaatctatc     1140

tgcttatgca gtttttcaga gtggaatgct tcctagaagt tactgaatgc accatggtca     1200

aaacggatta gggcatttga gaaatgcata ttgtattact agaagatgaa tacaaacaat     1260

ggaaactgaa tgctccagtc aacaaactat ttcttatata tgtgaacatt tatcaatcag     1320

tataattctg tactgatttt tgtaagacaa tccatgtaag gtatcagttg caataatact     1380

tctcaaacct gtttaaatat ttcaagacat taaatctatg aagtatataa tggtttcaaa     1440

gattcaaaat tgacattgct ttactgtcaa aataatttta tggctcacta tgaatctatt     1500

atactgtatt aagagtgaaa attgtcttct tctgtgctgg agatgtttta gagttaacaa     1560

tgatatatgg ataatgccgg tgagaataag agagtcataa accttaagta agcaacagca     1620

taacaaggtc caagatacct aaaagagatt tcaagagatt taattaatca tgaatgtgta     1680

acacagtgcc ttcaataaat ggtatagcaa atgttttgac atgaaaaaag gacaatttca     1740

aaaaaataaa ataaaataaa aataaattca cctagtctaa ggatgctaaa ccttagtact     1800

gagttacatt gtcatttata tagattataa cttgtctaaa taagtttgca atttgggaga     1860

tatattttta agataataat atatgtttac cttttaatta atgaaatatc tgtatttaat     1920

tttgacacta tatctgtata taaaatattt tcatacagca ttacaaattg cttactttgg     1980

aatacatttc tcctttgata aaataaatga gctatgtatt aaaaaaaaaa aaaaa          2035


<210>  7
<211>  1903
<212>  DNA
<213>  Homo sapiens

<400>  7
acatccgcgg caacgcctcc ttggtgtcgt ccgcttccaa taacccagct tgcgtcctgc       60

acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc      120

gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag      180

gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag      240

gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc      300

caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat      360

cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc      420

ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc      480

ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc      540

ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac      600

catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt      660

gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt      720

tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct      780

gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg aagaaaataa      840

atctttaaag gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga      900

gataaaaact tgttggaata aaattttgat gggcactaaa gaacactgaa aaatatggag      960

tggcaatata gaaacacgaa ctttagctgc atcctccaag aatctatctg cttatgcagt     1020

ttttcagagt ggaatgcttc ctagaagtta ctgaatgcac catggtcaaa acggattagg     1080

gcatttgaga aatgcatatt gtattactag aagatgaata caaacaatgg aaactgaatg     1140

ctccagtcaa caaactattt cttatatatg tgaacattta tcaatcagta taattctgta     1200

ctgatttttg taagacaatc catgtaaggt atcagttgca ataatacttc tcaaacctgt     1260

ttaaatattt caagacatta aatctatgaa gtatataatg gtttcaaaga ttcaaaattg     1320

acattgcttt actgtcaaaa taattttatg gctcactatg aatctattat actgtattaa     1380

gagtgaaaat tgtcttcttc tgtgctggag atgttttaga gttaacaatg atatatggat     1440

aatgccggtg agaataagag agtcataaac cttaagtaag caacagcata acaaggtcca     1500

agatacctaa aagagatttc aagagattta attaatcatg aatgtgtaac acagtgcctt     1560

caataaatgg tatagcaaat gttttgacat gaaaaaagga caatttcaaa aaaataaaat     1620

aaaataaaaa taaattcacc tagtctaagg atgctaaacc ttagtactga gttacattgt     1680

catttatata gattataact tgtctaaata agtttgcaat ttgggagata tatttttaag     1740

ataataatat atgtttacct tttaattaat gaaatatctg tatttaattt tgacactata     1800

tctgtatata aaatattttc atacagcatt acaaattgct tactttggaa tacatttctc     1860

ctttgataaa ataaatgagc tatgtattaa aaaaaaaaaa aaa                       1903


<210>  8
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  9
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Val Ser Val Phe Gly Ala 
    290                 295             


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 


Tyr Gly Pro Val Ser Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val 
                245                 250                 255     


Arg Asn Gln Glu Lys 
            260     


<210>  11
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 


Tyr Gly Pro Val Ser Pro Ile Ile Arg Gln Glu Leu 
                245                 250         


<210>  12
<211>  4617
<212>  DNA
<213>  Homo sapiens

<400>  12
atctaagctt ctctgtcttc ctccctccct cccttcctct tactctcatt catttcatac       60

acactggctc acacatctac tctctctctc tatctctctc agaatgacaa ttctaggtac      120

aacttttggc atggtttttt ctttacttca agtcgtttct ggagaaagtg gctatgctca      180

aaatggagac ttggaagatg cagaactgga tgactactca ttctcatgct atagccagtt      240

ggaagtgaat ggatcgcagc actcactgac ctgtgctttt gaggacccag atgtcaacat      300

caccaatctg gaatttgaaa tatgtggggc cctcgtggag gtaaagtgcc tgaatttcag      360

gaaactacaa gagatatatt tcatcgagac aaagaaattc ttactgattg gaaagagcaa      420

tatatgtgtg aaggttggag aaaagagtct aacctgcaaa aaaatagacc taaccactat      480

agttaaacct gaggctcctt ttgacctgag tgtcgtctat cgggaaggag ccaatgactt      540

tgtggtgaca tttaatacat cacacttgca aaagaagtat gtaaaagttt taatgcacga      600

tgtagcttac cgccaggaaa aggatgaaaa caaatggacg catgtgaatt tatccagcac      660

aaagctgaca ctcctgcaga gaaagctcca accggcagca atgtatgaga ttaaagttcg      720

atccatccct gatcactatt ttaaaggctt ctggagtgaa tggagtccaa gttattactt      780

cagaactcca gagatcaata atagctcagg ggagatggat cctatcttac taaccatcag      840

cattttgagt tttttctctg tcgctctgtt ggtcatcttg gcctgtgtgt tatggaaaaa      900

aaggattaag cctatcgtat ggcccagtct ccccgatcat aagaagactc tggaacatct      960

ttgtaagaaa ccaagaaaaa atttaaatgt gagtttcaat cctgaaagtt tcctggactg     1020

ccagattcat agggtggatg acattcaagc tagagatgaa gtggaaggtt ttctgcaaga     1080

tacgtttcct cagcaactag aagaatctga gaagcagagg cttggagggg atgtgcagag     1140

ccccaactgc ccatctgagg atgtagtcat cactccagaa agctttggaa gagattcatc     1200

cctcacatgc ctggctggga atgtcagtgc atgtgacgcc cctattctct cctcttccag     1260

gtccctagac tgcagggaga gtggcaagaa tgggcctcat gtgtaccagg acctcctgct     1320

tagccttggg actacaaaca gcacgctgcc ccctccattt tctctccaat ctggaatcct     1380

gacattgaac ccagttgctc agggtcagcc cattcttact tccctgggat caaatcaaga     1440

agaagcatat gtcaccatgt ccagcttcta ccaaaaccag tgaagtgtaa gaaacccaga     1500

ctgaacttac cgtgagcgac aaagatgatt taaaagggaa gtctagagtt cctagtctcc     1560

ctcacagcac agagaagaca aaattagcaa aaccccacta cacagtctgc aagattctga     1620

aacattgctt tgaccactct tcctgagttc agtggcactc aacatgagtc aagagcatcc     1680

tgcttctacc atgtggattt ggtcacaagg tttaaggtga cccaatgatt cagctattta     1740

aaaaaaaaag aggaaagaat gaaagagtaa aggaaatgat tgaggagtga ggaaggcagg     1800

aagagagcat gagaggaaag aaagaaagga aaataaaaaa tgatagttgc cattattagg     1860

atttaatata tatccagtgc tttgcaagtg ctctgcgcac cttgtctcac tccatcctga     1920

caataatcct gggaggtgtg tgcaattact acgactactc tcttttttat agatcattaa     1980

attcagaact aaggagttaa gtaacttgtc caagttgttc acacagtgaa gggaggggcc     2040

aagatatgat ggctgggagt ctaattgcag ttccctgagc catgtgcctt tctcttcact     2100

gaggactgcc ccattcttga gtgccaaacg tcactagtaa cagggtgtgc ctagataatt     2160

tatgatccaa actgagtcag tttggaaagt gaaagggaaa cttacatata atccctccgg     2220

gacaatgagc aaaaactagg actgtcccca gacaaatgtg aacatacata tcatcactta     2280

aattaaaatg gctatgagaa agaaagaggg ggagaaacag tcttgcgggt gtgaagtccc     2340

atgaccagcc atgtcaaaag aaggtaaaga agtcaagaaa aagccatgaa gcccatttgg     2400

tttcattttt ctgaaaatag gctcaagagg gaataaatta gaaactcaca atttctcttg     2460

tttgttacca agacagtgat tctcttgctg ctaccaccca actgcatccg tccatgatct     2520

cagaggaaac tgtcgctgac cctggacatg ggtacgtttg acgagtgaga ggaggcatga     2580

cccctcccat gtgtatagac actaccccaa cctaaattca tccctaaatt gtcccaagtt     2640

ctccagcaat agaggctgcc acaaacttca gggagaaaga gttacaagta catgcaatga     2700

gtgaactgac tgtggctaca atcttgaaga tatacggaag agacgtatta ttaatgcttg     2760

acatatatca tcttgccttt cttggtctag actgacttct aatgactaac tcaaagtcaa     2820

ggcaactgag taatgtcagc tcagcaaagt gcagcaaacc catctcccac aggcctccaa     2880

accctggctg ttcacagaac cacaaagggc agatgctgca cagaaaacta gagaaggggt     2940

cataggttca tggttttgtt tgagatttgt tgctactgtt tttctgtttt gaattttctt     3000

ctttgttctg tttttacttt atttaggggg actaggtgtt tctgatattt tagttttctt     3060

gtttgttttg ttttgtgttg tctgtgaatg gggttttaac tgtggatgaa tggaccttat     3120

ctgttggctt aaaggactgg taagatcaga ccatcttatt cttcaggtga atgttttact     3180

ttccaaagtg ctctcctctg caccagcagt aataaataca atgccataat cccttaggtt     3240

tgcctagtgc ttttgcaatt ttcaaagcac ttccataagc attccttcca cctccttgat     3300

aggcatttat ggaaagcctg ctacatgtca atcatactgt taggcacagg ggacctaaag     3360

acacataaaa ggatggcatt ctgcctcata aattgcaaaa cctaatgaaa gtgactgctt     3420

ggtaaacaaa ttattattat attataaaat gctataaaag agccatattg aaagtgccct     3480

gttggagaca gggcaaatgc cacaaaaatg atgtaaattt acatggagga aaagtagaat     3540

ctgcctggtt tgtaggcagc agaagacatt tttcatcagt gggcaggtgt tctttacctt     3600

ttgtagaaat gggagtcaag tctcaaatag gaggctccac aaaatctcat gccaggtctc     3660

tgatacctta ttcacagaag ttctttgaag tatttattgt tattttcttt gacttatggg     3720

aaaactggga cacaggaaga caggtaaatt acccaacctc acacgttaag tcagaactgg     3780

gagccataat tttgtatccc tggtataaat agacaatctc ttgaagaaat gaagagatga     3840

ccatagaaaa acatcgagat atctccagct ctaaaatcct ttgtttcaat gttgtttggc     3900

atatgttatc tttggaattt agtgtctgag cctctgtctg ttactgtagt atttaaaatg     3960

catgtattat aatcatataa tcataactgc tgttaattct tgattatata cctagggaca     4020

atgtgtaatg taagattact aattggttct gcccaatctc ctttcagatt ttattaggaa     4080

aaaaaaataa acctcctgat cggagacaat gtattaatca gaagtgtaaa ctgccagttc     4140

tatatagcat gaaatgaaaa gacagctaat ttggtccaac aaacatgact gggtctaggg     4200

cacccaggct gattcagctg atttcctacc agcctttgcc tcttccttca atgtggtttc     4260

catgggaatt tgcttcagaa aagccaagta tgggctgttc agaggtgcac acctgcattt     4320

tcttagctct tctagagggg ctaagagact tggtacgggc caggaagaat atgtggcaga     4380

gctcctggaa atgatgcaga ttaggtggca tttttgtcag ctctgtggtt tattgttggg     4440

actattcttt aaaatatcca ttgttcacta cagtgaagat ctctgattta accgtgtact     4500

atccacatgc attacaaaca tttcgcagag ctgcttagta tataagcgta caatgtatgt     4560

aataaccatc tcatatttaa ttaaatggta tagaagaaca aaaaaaaaaa aaaaaaa        4617


<210>  13
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  14
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Met Lys Thr Pro Gln Leu Glu Gln Ser Val Asp Tyr Arg His 
1               5                   10                  15      


Lys Phe Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg 
            20                  25                  30          


Val Arg Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser 
        35                  40                  45              


Glu Trp Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn 
    50                  55                  60                  


Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met 
65                  70                  75                  80  


Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr 
                85                  90                  95      


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
            100                 105                 110         


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
        115                 120                 125             


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
    130                 135                 140                 


Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro 
145                 150                 155                 160 


Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys 
                165                 170                 175     


Pro Glu Thr 
            


<210>  15
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  15
agaggaaacg tgtgggtggg gaggggtagt gggtgaggga cccaggttcc tgacacagac       60

agactacacc cagggaatga agagcaagcg ccatgttgaa gccatcatta ccattcacat      120

ccctcttatt cctgcagctg cccctgctgg gagtggggct gaacacgaca attctgacgc      180

ccaatgggaa tgaagacacc acagctgatt tcttcctgac cactatgccc actgactccc      240

tcagtgtttc cactctgccc ctcccagagg ttcagtgttt tgtgttcaat gtcgagtaca      300

tgaattgcac ttggaacagc agctctgagc cccagcctac caacctcact ctgcattatt      360

ggtacaagaa ctcggataat gataaagtcc agaagtgcag ccactatcta ttctctgaag      420

aaatcacttc tggctgtcag ttgcaaaaaa aggagatcca cctctaccaa acatttgttg      480

ttcagctcca ggacccacgg gaacccagga gacaggccac acagatgcta aaactgcaga      540

atctggtgat cccctgggct ccagagaacc taacacttca caaactgagt gaatcccagc      600

tagaactgaa ctggaacaac agattcttga accactgttt ggagcacttg gtgcagtacc      660

ggactgactg ggaccacagc tggactgaac aatcagtgga ttatagacat aagttctcct      720

tgcctagtgt ggatgggcag aaacgctaca cgtttcgtgt tcggagccgc tttaacccac      780

tctgtggaag tgctcagcat tggagtgaat ggagccaccc aatccactgg gggagcaata      840

cttcaaaaga gaatcctttc ctgtttgcat tggaagccgt ggttatctct gttggctcca      900

tgggattgat tatcagcctt ctctgtgtgt atttctggct ggaacggacg atgccccgaa      960

ttcccaccct gaagaaccta gaggatcttg ttactgaata ccacgggaac ttttcggcct     1020

ggagtggtgt gtctaaggga ctggctgaga gtctgcagcc agactacagt gaacgactct     1080

gcctcgtcag tgagattccc ccaaaaggag gggcccttgg ggaggggcct ggggcctccc     1140

catgcaacca gcatagcccc tactgggccc ccccatgtta caccctaaag cctgaaacct     1200

gaaccccaat cctctgacag aagaacccca gggtcctgta gccctaagtg gtactaactt     1260

tccttcattc aacccacctg cgtctcatac tcacctcacc ccactgtggc tgatttggaa     1320

ttttgtgccc ccatgtaagc accccttcat ttggcattcc ccacttgaga attacccttt     1380

tgccccgaac atgtttttct tctccctcag tctggccctt ccttttcgca ggattcttcc     1440

tccctccctc tttccctccc ttcctctttc catctaccct ccgattgttc ctgaaccgat     1500

gagaaataaa gtttctgttg ataatcatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560


<210>  16
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  17
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210>  18
<211>  2012
<212>  DNA
<213>  Homo sapiens

<400>  18
gttgggactc cgggtggcag gcgcccgggg gaatcccagc tgactcgctc actgccttcg       60

aagtccggcg ccccccggga gggaactggg tggccgcacc ctcccggctg cggtggctgt      120

cgccccccac cctgcagcca ggactcgatg gagaatccat tccaatatat ggccatgtgg      180

ctctttggag caatgttcca tcatgttcca tgctgctgac gtcacatgga gcacagaaat      240

caatgttagc agatagccag cccatacaag atcgtattgt attgtaggag gcattgtgga      300

tggatggctg ctggaaaccc cttgccatag ccagctcttc ttcaatactt aaggatttac      360

cgtggctttg agtaatgaga atttcgaaac cacatttgag aagtatttcc atccagtgct      420

acttgtgttt acttctaaac agtcattttc taactgaagc tggcattcat gtcttcattt      480

tgggctgttt cagtgcaggg cttcctaaaa cagaagccaa ctgggtgaat gtaataagtg      540

atttgaaaaa aattgaagat cttattcaat ctatgcatat tgatgctact ttatatacgg      600

aaagtgatgt tcaccccagt tgcaaagtaa cagcaatgaa gtgctttctc ttggagttac      660

aagttatttc acttgagtcc ggagatgcaa gtattcatga tacagtagaa aatctgatca      720

tcctagcaaa caacagtttg tcttctaatg ggaatgtaac agaatctgga tgcaaagaat      780

gtgaggaact ggaggaaaaa aatattaaag aatttttgca gagttttgta catattgtcc      840

aaatgttcat caacacttct tgattgcaat tgattctttt taaagtgttt ctgttattaa      900

caaacatcac tctgctgctt agacataaca aaacactcgg catttcaaat gtgctgtcaa      960

aacaagtttt tctgtcaaga agatgatcag accttggatc agatgaactc ttagaaatga     1020

aggcagaaaa atgtcattga gtaatatagt gactatgaac ttctctcaga cttactttac     1080

tcattttttt aatttattat tgaaattgta catatttgtg gaataatgta aaatgttgaa     1140

taaaaatatg tacaagtgtt gttttttaag ttgcactgat attttacctc ttattgcaaa     1200

atagcatttg tttaagggtg atagtcaaat tatgtattgg tggggctggg taccaatgct     1260

gcaggtcaac agctatgctg gtaggctcct gccagtgtgg aaccactgac tactggctct     1320

cattgacttc cttactaagc atagcaaaca gaggaagaat ttgttatcag taagaaaaag     1380

aagaactata tgtgaatcct cttctttata ctgtaattta gttattgatg tataaagcaa     1440

ctgttatgaa ataaagaaat tgcaataact ggcatataat gtccatcagt aaatcttggt     1500

ggtggtggca ataataaact tctactgata ggtagaatgg tgtgcaagct tgtccaatca     1560

cggattgcag gccacatgcg gcccaggaca actttgaatg tggcccaaca caaattcata     1620

aactttcata catctcgttt ttagctcatc agctatcatt agcggtagtg tatttaaagt     1680

gtggcccaag acaattcttc ttattccaat gtggcccagg gaaatcaaaa gattggatgc     1740

ccctggtata gaaaactaat agtgacagtg ttcatatttc atgctttccc aaatacaggt     1800

attttatttt cacattcttt ttgccatgtt tatataataa taaagaaaaa ccctgttgat     1860

ttgttggagc cattgttatc tgacagaaaa taattgttta tattttttgc actacactgt     1920

ctaaaattag caagctctct tctaatggaa ctgtaagaaa gatgaaatat ttttgtttta     1980

ttataaattt atttcacctt aaaaaaaaaa aa                                   2012


<210>  19
<211>  2333
<212>  DNA
<213>  Homo sapiens

<400>  19
gttgggactc cgggtggcag gcgcccgggg gaatcccagc tgactcgctc actgccttcg       60

aagtccggcg ccccccggga gggaactggg tggccgcacc ctcccggctg cggtggctgt      120

cgccccccac cctgcagcca ggactcgatg gagaatccat tccaatatat ggccatgtgg      180

ctctttggag caatgttcca tcatgttcca tgctgctgac gtcacatgga gcacagaaat      240

caatgttagc agatagccag cccatacaag atcgttttca actagtggcc ccactgtgtc      300

cggaattgat gggttcttgg tctcactgac ttcaagaatg aagccgcgga ccctcgcggt      360

gagtgttaca gctcttaagg tggcgcatct ggagtttgtt ccttctgatg ttcggatgtg      420

ttcggagttt cttccttctg gtgggttcgt ggtctcgctg gctcaggagt gaagctacag      480

accttcgcgg aggcattgtg gatggatggc tgctggaaac cccttgccat agccagctct      540

tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttcgaa accacatttg      600

agaagtattt ccatccagtg ctacttgtgt ttacttctaa acagtcattt tctaactgaa      660

gctggcattc atgtcttcat tttgggatgc agctaatata cccagttggc ccaaagcacc      720

taacctatag ttatataatc tgactctcag ttcagtttta ctctactaat gccttcatgg      780

tattgggaac catagatttg tgcagctgtt tcagtgcagg gcttcctaaa acagaagcca      840

actgggtgaa tgtaataagt gatttgaaaa aaattgaaga tcttattcaa tctatgcata      900

ttgatgctac tttatatacg gaaagtgatg ttcaccccag ttgcaaagta acagcaatga      960

agtgctttct cttggagtta caagttattt cacttgagtc cggagatgca agtattcatg     1020

atacagtaga aaatctgatc atcctagcaa acaacagttt gtcttctaat gggaatgtaa     1080

cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc     1140

agagttttgt acatattgtc caaatgttca tcaacacttc ttgattgcaa ttgattcttt     1200

ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg     1260

gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat     1320

cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa     1380

cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt     1440

ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga     1500

tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg     1560

gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg     1620

gaaccactga ctactggctc tcattgactt ccttactaag catagcaaac agaggaagaa     1680

tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt     1740

agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa     1800

tgtccatcag taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg     1860

gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat     1920

gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat     1980

tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag     2040

ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt     2100

catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata     2160

ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt     2220

atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa     2280

agatgaaata tttttgtttt attataaatt tatttcacct taaaaaaaaa aaa            2333


<210>  20
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  21
<211>  4050
<212>  DNA
<213>  Homo sapiens

<400>  21
gcagccagag ctcagcaggg ccctggagag atggccacgg tcccagcacc ggggaggact       60

ggagagcgcg cgctgccacc gccccatgtc tcagccaggg cttccttcct cggctccacc      120

ctgtggatgt aatggcggcc cctgctctgt cctggcgtct gcccctcctc atcctcctcc      180

tgcccctggc tacctcttgg gcatctgcag cggtgaatgg cacttcccag ttcacatgct      240

tctacaactc gagagccaac atctcctgtg tctggagcca agatggggct ctgcaggaca      300

cttcctgcca agtccatgcc tggccggaca gacggcggtg gaaccaaacc tgtgagctgc      360

tccccgtgag tcaagcatcc tgggcctgca acctgatcct cggagcccca gattctcaga      420

aactgaccac agttgacatc gtcaccctga gggtgctgtg ccgtgagggg gtgcgatgga      480

gggtgatggc catccaggac ttcaagccct ttgagaacct tcgcctgatg gcccccatct      540

ccctccaagt tgtccacgtg gagacccaca gatgcaacat aagctgggaa atctcccaag      600

cctcccacta ctttgaaaga cacctggagt tcgaggcccg gacgctgtcc ccaggccaca      660

cctgggagga ggcccccctg ctgactctca agcagaagca ggaatggatc tgcctggaga      720

cgctcacccc agacacccag tatgagtttc aggtgcgggt caagcctctg caaggcgagt      780

tcacgacctg gagcccctgg agccagcccc tggccttcag gacaaagcct gcagcccttg      840

ggaaggacac cattccgtgg ctcggccacc tcctcgtggg cctcagcggg gcttttggct      900

tcatcatctt agtgtacttg ctgatcaact gcaggaacac cgggccatgg ctgaagaagg      960

tcctgaagtg taacacccca gacccctcga agttcttttc ccagctgagc tcagagcatg     1020

gaggagacgt ccagaagtgg ctctcttcgc ccttcccctc atcgtccttc agccctggcg     1080

gcctggcacc tgagatctcg ccactagaag tgctggagag ggacaaggtg acgcagctgc     1140

tcctgcagca ggacaaggtg cctgagcccg catccttaag cagcaaccac tcgctgacca     1200

gctgcttcac caaccagggt tacttcttct tccacctccc ggatgccttg gagatagagg     1260

cctgccaggt gtactttact tacgacccct actcagagga agaccctgat gagggtgtgg     1320

ccggggcacc cacagggtct tccccccaac ccctgcagcc tctgtcaggg gaggacgacg     1380

cctactgcac cttcccctcc agggatgacc tgctgctctt ctcccccagt ctcctcggtg     1440

gccccagccc cccaagcact gcccctgggg gcagtggggc cggtgaagag aggatgcccc     1500

cttctttgca agaaagagtc cccagagact gggaccccca gcccctgggg cctcccaccc     1560

caggagtccc agacctggtg gattttcagc caccccctga gctggtgctg cgagaggctg     1620

gggaggaggt ccctgacgct ggccccaggg agggagtcag tttcccctgg tccaggcctc     1680

ctgggcaggg ggagttcagg gcccttaatg ctcgcctgcc cctgaacact gatgcctact     1740

tgtccctcca agaactccag ggtcaggacc caactcactt ggtgtagaca gatggccagg     1800

gtgggaggca ggcagctgcc tgctctgcgc cgagcctcag aaggaccctg ttgagggtcc     1860

tcagtccact gctgaggaca ctcagtgtcc agttgcagct ggacttctcc acccggatgg     1920

cccccaccca gtcctgcaca cttggtccat ccatttccaa acctccactg ctgctcccgg     1980

gtcctgctgc ccgagccagg aactgtgtgt gttgcagggg ggcagtaact ccccaactcc     2040

ctcgttaatc acaggatccc acgaatttag gctcagaagc atcgctcctc tccagccctg     2100

cagctattca ccaatatcag tcctcgcggc tctccagggc tccctgccct gacctcttcc     2160

ctgggttttc tgccccagcc tcctccttcc ctcccctccc cgtccacagg gcagcctgag     2220

cgtgctttcc aaaacccaaa tatggccacg ctccccctcg gttcaaaacc ttgcacaggt     2280

cccactgccc tcagccccac ttctcagcct ggtacttgta cctccggtgt cgtgtgggga     2340

catccccttc tgcaatcctc cctaccgtcc tcctgagcca ctcagagctc cctcacaccc     2400

cctctgttgc acatgctatt ccctggggct gctgtgcgct ccccctcatc taggtgacaa     2460

acttccctga ctcttcaagt gccggttttg cttctcctgg agggaagcac tgcctccctt     2520

aatctgccag aaacttctag cgtcagtgct ggagggagaa gctgtcaggg acccagggcg     2580

cctggagaaa gaggccctgt tactattcct ttgggatctc tgaggcctca gagtgcttgg     2640

ctgctgtatc tttaatgctg gggcccaagt aagggcacag atccccccac aaagtggatg     2700

cctgctgcat cttcccacag tggcttcaca gacccacaag agaagctgat ggggagtaaa     2760

ccctggagtc cgaggcccag gcagcagccc cgcctagtgg tgggccctga tgctgccagg     2820

cctgggacct cccactgccc cctccactgg aggggtctcc tctgcagctc agggactggc     2880

acactggcct ccagaagggc agctccacag ggcagggcct cattattttt cactgcccca     2940

gacacagtgc ccaacacccc gtcgtatacc ctggatgaac gaattaatta cctggcacca     3000

cctcgtctgg gctccctgcg cctgacattc acacagagag gcagagtccc gtgcccatta     3060

ggtctggcat gccccctcct gcaaggggct caacccccta ccccgacccc tccacgtatc     3120

tttcctaggc agatcacgtt gcaatggctc aaacaacatt ccaccccagc aggacagtga     3180

ccccagtccc agctaactct gacctgggag ccctcaggca cctgcactta caggccttgc     3240

tcacagctga ttgggcacct gaccacacgc ccccacaggc tctgaccagc agcctatgag     3300

ggggtttggc accaagctct gtccaatcag gtaggctggg cctgaactag ccaatcagat     3360

caactctgtc ttgggcgttt gaactcaggg agggaggccc ttgggagcag gtgcttgtgg     3420

acaaggctcc acaagcgttg agccttggaa aggtagacaa gcgttgagcc actaagcaga     3480

ggaccttggg ttcccaatac aaaaatacct actgctgaga gggctgctga ccatttggtc     3540

aggattcctg ttgcctttat atccaaaata aactcccctt tcttgaggtt gtctgagtct     3600

tgggtctatg ccttgaaaaa agctgaatta ttggacagtc tcacctcctg ccatagggtc     3660

ctgaatgttt cagaccacaa ggggctccac acctttgctg tgtgttctgg ggcaacctac     3720

taatcctctc tgcaagtcgg tctccttatc cccccaaatg gaaattgtat ttgccttctc     3780

cactttggga ggctcccact tcttgggagg gttacatttt ttaagtctta atcatttgtg     3840

acatatgtat ctatacatcc gtatctttta atgatccgtg tgtaccatct ttgtgattat     3900

ttccttaata ttttttcttt aagtcagttc attttcgttg aaatacattt atttaaagaa     3960

aaatctttgt tactctgtaa atgaaaaaac ccattttcgc tataaataaa aggtaactgt     4020

acaaaataag tacaatgcaa caaaaaaaaa                                      4050


<210>  22
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  23
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
        195                 200                 205             


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
    210                 215                 220                 


Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 


<210>  24
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg 
225                 230                 235                 240 


Ser Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
                245                 250         


<210>  25
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser 
        195                 200                 205             


Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
    210                 215                 


<210>  26
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asp Pro 
            20                  25                  30          


Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala 
        35                  40                  45              


Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro 
    50                  55                  60                  


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
65                  70                  75                  80  


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
                85                  90                  95      


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
            100                 105                 110         


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
        115                 120                 125             


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
    130                 135                 140                 


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
145                 150                 155                 160 


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
                165                 170                 175     


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
            180                 185                 190         


Glu Asp Leu Glu Asn Cys Ser His His Leu 
        195                 200         


<210>  27
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asp Pro 
            20                  25                  30          


Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala 
        35                  40                  45              


Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro 
    50                  55                  60                  


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
65                  70                  75                  80  


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
                85                  90                  95      


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
            100                 105                 110         


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
        115                 120                 125             


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
    130                 135                 140                 


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
145                 150                 155                 160 


Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser 
                165                 170                 175     


Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
            180                 185         


<210>  28
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Glu Pro Ala 
            20                  25                  30          


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
        35                  40                  45              


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
    50                  55                  60                  


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
65                  70                  75                  80  


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
                85                  90                  95      


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr 
            100                 105                 110         


Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys 
        115                 120                 125             


Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu 
    130                 135                 140                 


Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu 
145                 150                 155                 160 


Asp Leu Glu Asn Cys Ser His His Leu 
                165                 


<210>  29
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Glu Pro Ala 
            20                  25                  30          


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
        35                  40                  45              


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
    50                  55                  60                  


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
65                  70                  75                  80  


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
                85                  90                  95      


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr 
            100                 105                 110         


Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys 
        115                 120                 125             


Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser Ala 
    130                 135                 140                 


Gly His Thr Cys Ser Val Gly Ser Val Cys 
145                 150                 


<210>  30
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
    50                  55                  60                  


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
                85                  90                  95      


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
            100                 105                 110         


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
        115                 120                 125             


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
    130                 135                 140                 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
145                 150                 155                 160 


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
                165                 170                 175     


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
            180                 185                 190         


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
        195                 200                 205             


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
    210                 215                 220                 


Glu Asn Cys Ser His His Leu 
225                 230     


<210>  31
<211>  1657
<212>  DNA
<213>  Homo sapiens

<400>  31
aaaagcgaaa gcgaatgcga ctggcggggc ggcaggtccc agagcagcgc tcgccacctc       60

cccccggcct gggcagcgct cgcccgggga gtccagcggt gtcctgtgga gctgccgcca      120

tggccccgcg gcgggcgcgc ggctgccgga ccctcggtct cccggcgctg ctactgctgc      180

tgctgctccg gccgccggcg acgcggggca tcacgtgccc tccccccatg tccgtggaac      240

acgcagacat ctgggtcaag agctacagct tgtactccag ggagcggtac atttgtaact      300

ctggtttcaa gcgtaaagcc ggcacgtcca gcctgacgga gtgcgtgttg aacaaggcca      360

cgaatgtcgc ccactggaca acccccagtc tcaaatgcat tagagaccct gccctggttc      420

accaaaggcc agcgccaccc tccacagtaa cgacggcagg ggtgacccca cagccagaga      480

gcctctcccc ttctggaaaa gagcccgcag cttcatctcc cagctcaaac aacacagcgg      540

ccacaacagc agctattgtc ccgggctccc agctgatgcc ttcaaaatca ccttccacag      600

gaaccacaga gataagcagt catgagtcct cccacggcac cccctctcag acaacagcca      660

agaactggga actcacagca tccgcctccc accagccgcc aggtgtgtat ccacagggcc      720

acagcgacac cactgtggct atctccacgt ccactgtcct gctgtgtggg ctgagcgctg      780

tgtctctcct ggcatgctac ctcaagtcaa ggcaaactcc cccgctggcc agcgttgaaa      840

tggaagccat ggaggctctg ccggtgactt gggggaccag cagcagagat gaagacttgg      900

aaaactgctc tcaccaccta tgaaactcgg ggaaaccagc ccagctaagt ccggagtgaa      960

ggagcctctc tgctttagct aaagacgact gagaagaggt gcaaggaagc gggctccagg     1020

agcaagctca ccaggcctct cagaagtccc agcaggatct cacggactgc cgggtcggcg     1080

cctcctgcgc gagggagcag gttctccgca ttcccatggg caccacctgc ctgcctgtcg     1140

tgccttggac ccagggccca gcttcccagg agagaccaaa ggcttctgag caggattttt     1200

atttcattac agtgtgagct gcctggaata catgtggtaa tgaaataaaa accctgcccc     1260

gaatcttccg tccctcatcc taactttcag ttcacagaga aaagtgacat acccaaagct     1320

ctctgtcaat tacaaggctt ctcctggcgt gggagacgtc tacagggaag acaccagcgt     1380

ttgggcttct aaccaccctg tctccagctg ctctgcacac atggacaggg acctgggaaa     1440

ggtgggagag atgctgagcc cagcgaatcc tctccattga aggattcagg aagaagaaaa     1500

ctcaactcag tgccatttta cgaatatatg cgtttatatt tatacttcct tgtctattat     1560

atctatacat tatatattat ttgtattttg acattgtacc ttgtataaac aaaataaaac     1620

atctattttc aatattttta aaatgcaaaa aaaaaaa                              1657


<210>  32
<211>  1558
<212>  DNA
<213>  Homo sapiens

<400>  32
aaaagcgaaa gcgaatgcga ctggcggggc ggcaggtccc agagcagcgc tcgccacctc       60

cccccggcct gggcagcgct cgcccgggga gtccagcggt gtcctgtgga gctgccgcca      120

tggccccgcg gcgggcgcgc ggctgccgga ccctcggtct cccggcgctg ctactgctgc      180

tgctgctccg gccgccggcg acgcggggca tcacgtgccc tccccccatg tccgtggaac      240

acgcagacat ctgggtcaag agctacagct tgtactccag ggagcggtac atttgtaact      300

ctggtttcaa gcgtaaagcc ggcacgtcca gcctgacgga gtgcgtgttg aacaaggcca      360

cgaatgtcgc ccactggaca acccccagtc tcaaatgcat taagcccgca gcttcatctc      420

ccagctcaaa caacacagcg gccacaacag cagctattgt cccgggctcc cagctgatgc      480

cttcaaaatc accttccaca ggaaccacag agataagcag tcatgagtcc tcccacggca      540

ccccctctca gacaacagcc aagaactggg aactcacagc atccgcctcc caccagccgc      600

caggtgtgta tccacagggc cacagcgaca ccactgtggc tatctccacg tccactgtcc      660

tgctgtgtgg gctgagcgct gtgtctctcc tggcatgcta cctcaagtca aggcaaactc      720

ccccgctggc cagcgttgaa atggaagcca tggaggctct gccggtgact tgggggacca      780

gcagcagaga tgaagacttg gaaaactgct ctcaccacct atgaaactcg gggaaaccag      840

cccagctaag tccggagtga aggagcctct ctgctttagc taaagacgac tgagaagagg      900

tgcaaggaag cgggctccag gagcaagctc accaggcctc tcagaagtcc cagcaggatc      960

tcacggactg ccgggtcggc gcctcctgcg cgagggagca ggttctccgc attcccatgg     1020

gcaccacctg cctgcctgtc gtgccttgga cccagggccc agcttcccag gagagaccaa     1080

aggcttctga gcaggatttt tatttcatta cagtgtgagc tgcctggaat acatgtggta     1140

atgaaataaa aaccctgccc cgaatcttcc gtccctcatc ctaactttca gttcacagag     1200

aaaagtgaca tacccaaagc tctctgtcaa ttacaaggct tctcctggcg tgggagacgt     1260

ctacagggaa gacaccagcg tttgggcttc taaccaccct gtctccagct gctctgcaca     1320

catggacagg gacctgggaa aggtgggaga gatgctgagc ccagcgaatc ctctccattg     1380

aaggattcag gaagaagaaa actcaactca gtgccatttt acgaatatat gcgtttatat     1440

ttatacttcc ttgtctatta tatctataca ttatatatta tttgtatttt gacattgtac     1500

cttgtataaa caaaataaaa catctatttt caatattttt aaaatgcaaa aaaaaaaa       1558


<210>  33
<211>  1861
<212>  DNA
<213>  Homo sapiens

<400>  33
agctgcagca ggaattcggc gaagtggcgg agctggggcc ccagcgggcg ccgggggccg       60

cgggagccag caggtggcgg gggctgcgct ccgcccgggc cagagcgcac caggcaggtg      120

cccgcgcctc cgcaccgcgg cgacacctcc gcgggcactc acccaggccg gccgctcaca      180

accgagcgca gggccgcgga gggagaccag gaaagccgaa ggcggagcag ctggaggcga      240

ccagcgccgg gcgaggtcaa gtggatccga gccgcagaga gggctggaga gagtctgctc      300

tccgatgact ttgcccactc tcttcgcagt ggggacaccg gaccgagtgc acactggagg      360

tcccagagca cgacgagcgc ggaggaccgg gaggctcccg ggcttgcgtg ggcatcacgt      420

gccctccccc catgtccgtg gaacacgcag acatctgggt caagagctac agcttgtact      480

ccagggagcg gtacatttgt aactctggtt tcaagcgtaa agccggcacg tccagcctga      540

cggagtgcgt gttgaacaag gccacgaatg tcgcccactg gacaaccccc agtctcaaat      600

gcattagaga ccctgccctg gttcaccaaa ggccagcgcc accctccaca gtaacgacgg      660

caggggtgac cccacagcca gagagcctct ccccttctgg aaaagagccc gcagcttcat      720

ctcccagctc aaacaacaca gcggccacaa cagcagctat tgtcccgggc tcccagctga      780

tgccttcaaa atcaccttcc acaggaacca cagagataag cagtcatgag tcctcccacg      840

gcaccccctc tcagacaaca gccaagaact gggaactcac agcatccgcc tcccaccagc      900

cgccaggtgt gtatccacag ggccacagcg acaccactgt ggctatctcc acgtccactg      960

tcctgctgtg tgggctgagc gctgtgtctc tcctggcatg ctacctcaag tcaaggcaaa     1020

ctcccccgct ggccagcgtt gaaatggaag ccatggaggc tctgccggtg acttggggga     1080

ccagcagcag agatgaagac ttggaaaact gctctcacca cctatgaaac tcggggaaac     1140

cagcccagct aagtccggag tgaaggagcc tctctgcttt agctaaagac gactgagaag     1200

aggtgcaagg aagcgggctc caggagcaag ctcaccaggc ctctcagaag tcccagcagg     1260

atctcacgga ctgccgggtc ggcgcctcct gcgcgaggga gcaggttctc cgcattccca     1320

tgggcaccac ctgcctgcct gtcgtgcctt ggacccaggg cccagcttcc caggagagac     1380

caaaggcttc tgagcaggat ttttatttca ttacagtgtg agctgcctgg aatacatgtg     1440

gtaatgaaat aaaaaccctg ccccgaatct tccgtccctc atcctaactt tcagttcaca     1500

gagaaaagtg acatacccaa agctctctgt caattacaag gcttctcctg gcgtgggaga     1560

cgtctacagg gaagacacca gcgtttgggc ttctaaccac cctgtctcca gctgctctgc     1620

acacatggac agggacctgg gaaaggtggg agagatgctg agcccagcga atcctctcca     1680

ttgaaggatt caggaagaag aaaactcaac tcagtgccat tttacgaata tatgcgttta     1740

tatttatact tccttgtcta ttatatctat acattatata ttatttgtat tttgacattg     1800

taccttgtat aaacaaaata aaacatctat tttcaatatt tttaaaatgc aaaaaaaaaa     1860

a                                                                     1861


<210>  34
<211>  1810
<212>  DNA
<213>  Homo sapiens

<400>  34
aaaagcgaaa gcgaatgcga ctggcggggc ggcaggtccc agagcagcgc tcgccacctc       60

cccccggcct gggcagcgct cgcccgggga gtccagcggt gtcctgtgga gctgccgcca      120

tggccccgcg gcgggcgcgc ggctgccgga ccctcggtct cccggcgctg ctactgctgc      180

tgctgctccg gccgccggcg acgcgggatg caagagacag gctggctgtc ctggcgggaa      240

ggagcagaat atctgaaagc ttcaaccatg aggtccagac acacgaggcc tgcgtgagac      300

tcaggacaat ggaaaactgc ccccagtgcc accaccatcg gacaagcagg cagcaagcag      360

gcatcacgtg ccctcccccc atgtccgtgg aacacgcaga catctgggtc aagagctaca      420

gcttgtactc cagggagcgg tacatttgta actctggttt caagcgtaaa gccggcacgt      480

ccagcctgac ggagtgcgtg ttgaacaagg ccacgaatgt cgcccactgg acaaccccca      540

gtctcaaatg cattagagac cctgccctgg ttcaccaaag gccagcgcca ccctccacag      600

taacgacggc aggggtgacc ccacagccag agagcctctc cccttctgga aaagagcccg      660

cagcttcatc tcccagctca aacaacacag cggccacaac agcagctatt gtcccgggct      720

cccagctgat gccttcaaaa tcaccttcca caggaaccac agagataagc agtcatgagt      780

cctcccacgg caccccctct cagacaacag ccaagaactg ggaactcaca gcatccgcct      840

cccaccagcc gccaggtgtg tatccacagg gccacagcga caccactgtg gctatctcca      900

cgtccactgt cctgctgtgt gggctgagcg ctgtgtctct cctggcatgc tacctcaagt      960

caaggcaaac tcccccgctg gccagcgttg aaatggaagc catggaggct ctgccggtga     1020

cttgggggac cagcagcaga gatgaagact tggaaaactg ctctcaccac ctatgaaact     1080

cggggaaacc agcccagcta agtccggagt gaaggagcct ctctgcttta gctaaagacg     1140

actgagaaga ggtgcaagga agcgggctcc aggagcaagc tcaccaggcc tctcagaagt     1200

cccagcagga tctcacggac tgccgggtcg gcgcctcctg cgcgagggag caggttctcc     1260

gcattcccat gggcaccacc tgcctgcctg tcgtgccttg gacccagggc ccagcttccc     1320

aggagagacc aaaggcttct gagcaggatt tttatttcat tacagtgtga gctgcctgga     1380

atacatgtgg taatgaaata aaaaccctgc cccgaatctt ccgtccctca tcctaacttt     1440

cagttcacag agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg     1500

cgtgggagac gtctacaggg aagacaccag cgtttgggct tctaaccacc ctgtctccag     1560

ctgctctgca cacatggaca gggacctggg aaaggtggga gagatgctga gcccagcgaa     1620

tcctctccat tgaaggattc aggaagaaga aaactcaact cagtgccatt ttacgaatat     1680

atgcgtttat atttatactt ccttgtctat tatatctata cattatatat tatttgtatt     1740

ttgacattgt accttgtata aacaaaataa aacatctatt ttcaatattt ttaaaatgca     1800

aaaaaaaaaa                                                            1810


<210>  35
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
        195                 200                 205             


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
    210                 215                 220                 


Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 


<210>  36
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg 
                85                  90                  95      


Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr 
            100                 105                 110         


Lys Glu His 
        115 


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Polypeptide in soluble human IL-7R alpha (CD127)-Fc 
       chimera

<400>  37

Ile Ile Glu Gly Arg Met Asp 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Linker in soluble human IL-15R alpha-Fc chimera

<400>  38

Ile Glu Gly Arg Asp Met Asp 
1               5           


