                         SEQUENCE LISTING

<110>  Vaccibody AS
 
<120>  Therapeutic anticancer neoepitope vaccine

<130>  P4068PC00

<160>  131   

<170>  PatentIn version 3.5

<210>  1
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  2
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector

<400>  2
atgcaggtct ccactgctgc ccttgccgtc ctcctctgca ccatggctct ctgcaaccag       60

gtcctctctg caccacttgc tgctgacacg ccgaccgcct gctgcttcag ctacacctcc      120

cgacagattc cacagaattt catagctgac tactttgaga cgagcagcca gtgctccaag      180

cccagtgtca tcttcctaac caagagaggc cggcaggtct gtgctgaccc cagtgaggag      240

tgggtccaga aatacgtcag tgacctggag ctgagtgccg agctcaaaac cccacttggt      300

gacacaactc acacagagcc caaatcttgt gacacacctc ccccgtgccc aaggtgccca      360

ggcggtggaa gcagcggagg tggaagtgga ggacagcccc gagaaccaca ggtgtacacc      420

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      480

ggcttctacc ccagcgacat cgccgtggag tgggagagca gcgggcagcc ggagaacaac      540

tacaacacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc      600

accgtggaca agagcaggtg gcagcagggg aacatcttct catgctccgt gatgcatgag      660

gctctgcaca accgcttcac gcagaagagc ctctccctgt ctccgggtaa aggcctcggt      720

ggcctg                                                                 726


<210>  3
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homodimeric construct

<400>  3

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu 
            


<210>  4
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  4

Pro Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser 
1               5                   10                  15      


Pro Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu 
            20                  25          


<210>  5
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg 
1               5                   10                  15      


His Gly Thr Thr His Ser Leu Val Ile His Asp 
            20                  25          


<210>  6
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  6

Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val 
1               5                   10                  15      


His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser 
            20                  25          


<210>  7
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln 
1               5                   10                  15      


Val Leu Leu Gly Arg Lys Val Val Val Val Arg 
            20                  25          


<210>  8
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  8

Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Ala Met Asp 
1               5                   10                  15      


Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met 
            20                  25          


<210>  9
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  9

Val Val Asp Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu 
1               5                   10                  15      


Met Lys Gly Leu Cys Glu Lys Pro Leu Ala Ser 
            20                  25          


<210>  10
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly 
1               5                   10                  15      


Phe Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met 
            20                  25          


<210>  11
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro 
1               5                   10                  15      


Gly Pro Met Val Val Phe Ala Thr Pro Gly Met 
            20                  25          


<210>  12
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  12

Ser Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln 
1               5                   10                  15      


Ile Phe Glu Asn Pro Val Asp Trp Lys Glu Lys 
            20                  25          


<210>  13
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu 
1               5                   10                  15      


His Met Ala Arg Gly Leu Lys Tyr Leu His Gln 
            20                  25          


<210>  14
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  14

Val Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu 
1               5                   10                  15      


Gln Pro Ala Gln Ala Gln Met Leu Thr Pro Pro 
            20                  25          


<210>  15
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  15

Leu His Ser Gly Gln Asn His Leu Lys Glu Met Ala Ile Ser Val Leu 
1               5                   10                  15      


Glu Ala Arg Ala Cys Ala Ala Ala Gly Gln Ser 
            20                  25          


<210>  16
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  16

Pro Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu 
1               5                   10                  15      


Glu Leu Asn Ser Ser Ala Leu Pro Pro Thr Glu 
            20                  25          


<210>  17
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  17

Ala Gly Thr Gln Cys Glu Tyr Trp Ala Ser Arg Ala Leu Asp Ser Glu 
1               5                   10                  15      


His Ser Ile Gly Ser Met Ile Gln Leu Pro Gln 
            20                  25          


<210>  18
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  18

Ala Ala Tyr Lys Gly His His Tyr Pro Gly Pro Gly Asn Tyr Phe Trp 
1               5                   10                  15      


Lys Cys Leu Phe Met Ser Gly Leu Ser Glu Val 
            20                  25          


<210>  19
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Val Leu Leu 
1               5                   10                  15      


Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr 
            20                  25          


<210>  20
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala 
1               5                   10                  15      


Ile Cys Gly Met Pro Leu Asp Ser Phe Arg Ala 
            20                  25          


<210>  21
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile 
1               5                   10                  15      


Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro His 
            20                  25          


<210>  22
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  22

Gly Tyr Ile Ser Arg Val Thr Ala Gly Lys Asp Ser Tyr Ile Ala Leu 
1               5                   10                  15      


Val Asp Lys Asn Ile Met Gly Tyr Ile Ala Ser 
            20                  25          


<210>  23
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  23

Glu His Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln 
1               5                   10                  15      


Val Gly Phe Gly Arg Ile Gly Lys His Phe Trp 
            20                  25          


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Gly Leu Ser Gly Leu 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Leu Gly Gly Leu 
1               5   


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge region

<400>  26

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge region

<400>  27

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  29
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  30
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  30

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Val 
            340                 345                 350         


Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln 
        355                 360                 365             


Pro Ala Gln Ala Gln Met Leu Thr Pro Pro Gly Gly Gly Gly Ser Leu 
    370                 375                 380                 


His Ser Gly Gln Asn His Leu Lys Glu Met Ala Ile Ser Val Leu Glu 
385                 390                 395                 400 


Ala Arg Ala Cys Ala Ala Ala Gly Gln Ser Gly Gly Gly Gly Ser Pro 
                405                 410                 415     


Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu 
            420                 425                 430         


Leu Asn Ser Ser Ala Leu Pro Pro Thr Glu Gly Gly Gly Gly Ser Ala 
        435                 440                 445             


Gly Thr Gln Cys Glu Tyr Trp Ala Ser Arg Ala Leu Asp Ser Glu His 
    450                 455                 460                 


Ser Ile Gly Ser Met Ile Gln Leu Pro Gln Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Ala Tyr Lys Gly His His Tyr Pro Gly Pro Gly Asn Tyr Phe Trp Lys 
                485                 490                 495     


Cys Leu Phe Met Ser Gly Leu Ser Glu Val Gly Gly Gly Gly Ser Asp 
            500                 505                 510         


Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Val Leu Leu Gln 
        515                 520                 525             


Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Gly Gly Gly Gly Ser Asp 
    530                 535                 540                 


Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile 
545                 550                 555                 560 


Cys Gly Met Pro Leu Asp Ser Phe Arg Ala Gly Gly Gly Gly Ser Glu 
                565                 570                 575     


Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu 
            580                 585                 590         


Ser Ala Trp Leu Leu Glu Leu Ala Pro His Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Tyr Ile Ser Arg Val Thr Ala Gly Lys Asp Ser Tyr Ile Ala Leu Val 
    610                 615                 620                 


Asp Lys Asn Ile Met Gly Tyr Ile Ala Ser Gly Gly Gly Gly Ser Glu 
625                 630                 635                 640 


His Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val 
                645                 650                 655     


Gly Phe Gly Arg Ile Gly Lys His Phe Trp 
            660                 665     


<210>  31
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  31

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Val 
            340                 345                 350         


Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln 
        355                 360                 365             


Pro Ala Gln Ala Gln Met Leu Thr Pro Pro Gly Gly Gly Gly Ser Leu 
    370                 375                 380                 


His Ser Gly Gln Asn His Leu Lys Glu Met Ala Ile Ser Val Leu Glu 
385                 390                 395                 400 


Ala Arg Ala Cys Ala Ala Ala Gly Gln Ser Gly Gly Gly Gly Ser Pro 
                405                 410                 415     


Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu 
            420                 425                 430         


Leu Asn Ser Ser Ala Leu Pro Pro Thr Glu 
        435                 440         


<210>  32
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  32

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Met Gln Val Ser Thr Ala Ala Leu Ala 
145                 150                 155                 160 


Val Leu Leu Cys Thr Met Ala Leu Cys Asn Gln Val Leu Ser Ala Pro 
                165                 170                 175     


Leu Ala Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr Ser Arg 
            180                 185                 190         


Gln Ile Pro Gln Asn Phe Ile Ala Asp Tyr Phe Glu Thr Ser Ser Gln 
        195                 200                 205             


Cys Ser Lys Pro Ser Val Ile Phe Leu Thr Lys Arg Gly Arg Gln Val 
    210                 215                 220                 


Cys Ala Asp Pro Ser Glu Glu Trp Val Gln Lys Tyr Val Ser Asp Leu 
225                 230                 235                 240 


Glu Leu Ser Ala Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
                245                 250                 255     


Ile Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            260                 265                 270         


Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro 
        275                 280                 285             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    290                 295                 300                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
305                 310                 315                 320 


Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr 
                325                 330                 335     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            340                 345                 350         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser 
        355                 360                 365             


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
    370                 375                 380                 


Leu Ser Pro Gly Lys Gly Leu Gly Gly Leu Met His Gly Asp Thr Pro 
385                 390                 395                 400 


Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu 
                405                 410                 415     


Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile 
            420                 425                 430         


Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
        435                 440                 445             


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
    450                 455                 460                 


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
465                 470                 475                 480 


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Gly Gly Ser 
                485                 490                 495     


Ser Gly Gly Gly Ser Gly Pro Ser Lys Pro Ser Phe Gln Glu Phe Val 
            500                 505                 510         


Asp Trp Glu Asn Val Ser Pro Glu Leu Asn Ser Thr Asp Gln Pro Phe 
        515                 520                 525             


Leu Gly Gly Gly Gly Ser Arg Glu Gly Val Glu Leu Cys Pro Gly Asn 
    530                 535                 540                 


Lys Tyr Glu Met Arg Arg His Gly Thr Thr His Ser Leu Val Ile His 
545                 550                 555                 560 


Asp Gly Gly Gly Gly Ser Ser His Cys His Trp Asn Asp Leu Ala Val 
                565                 570                 575     


Ile Pro Ala Gly Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val 
            580                 585                 590         


Ser Gly Gly Gly Gly Ser Gly Arg Gly His Leu Leu Gly Arg Leu Ala 
        595                 600                 605             


Ala Ile Val Gly Lys Gln Val Leu Leu Gly Arg Lys Val Val Val Val 
    610                 615                 620                 


Arg Gly Gly Gly Gly Ser Phe Arg Arg Lys Ala Phe Leu His Trp Tyr 
625                 630                 635                 640 


Thr Gly Glu Ala Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn 
                645                 650                 655     


Met Gly Gly Gly Gly Ser Val Val Asp Arg Asn Pro Gln Phe Leu Asp 
            660                 665                 670         


Pro Val Leu Ala Tyr Leu Met Lys Gly Leu Cys Glu Lys Pro Leu Ala 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Ser Ser Pro Asp Glu Val Ala Leu Val Glu 
    690                 695                 700                 


Gly Val Gln Ser Leu Gly Phe Thr Tyr Leu Arg Leu Lys Asp Asn Tyr 
705                 710                 715                 720 


Met Gly Gly Gly Gly Ser Glu Phe Lys His Ile Lys Ala Phe Asp Arg 
                725                 730                 735     


Thr Phe Ala Asn Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly 
            740                 745                 750         


Met Gly Gly Gly Gly Ser Ser Thr Ala Asn Tyr Asn Thr Ser His Leu 
        755                 760                 765             


Asn Asn Asp Val Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys Glu 
    770                 775                 780                 


Lys Gly Gly Gly Gly Ser Asp Ser Gly Ser Pro Phe Pro Ala Ala Val 
785                 790                 795                 800 


Ile Leu Arg Asp Ala Leu His Met Ala Arg Gly Leu Lys Tyr Leu His 
                805                 810                 815     


Gln 
    


<210>  33
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  33

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Arg 
    370                 375                 380                 


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
385                 390                 395                 400 


Gly Thr Thr His Ser Leu Val Ile His Asp Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            420                 425                 430         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser 
        435                 440         


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  34

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  35
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  35

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro 
            20          


<210>  36
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  36

Ala Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met Phe 
1               5                   10                  15      


Thr Ala Thr Met Pro Pro Ala Val Glu Arg Leu 
            20                  25          


<210>  37
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  37

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr 
385                 390                 395                 400 


Glu Met Arg Arg His Gly Thr Thr His Ser Leu Val Ile His Asp Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Cys His Trp Asn Asp 
            420                 425                 430         


Leu Ala Val Ile Pro Ala Gly Val Val His Asn Trp Asp Phe Glu Pro 
        435                 440                 445             


Arg Lys Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg 
    450                 455                 460                 


Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val Leu 
465                 470                 475                 480 


Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu 
            500                 505                 510         


Ala Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Val Val Asp Arg Asn Pro Gln Phe 
    530                 535                 540                 


Leu Asp Pro Val Leu Ala Tyr Leu Met Lys Gly Leu Cys Glu Lys Pro 
545                 550                 555                 560 


Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Pro 
                565                 570                 575     


Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe Thr Tyr 
            580                 585                 590         


Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn 
    610                 615                 620                 


Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Ser Thr Ala Asn Tyr Asn Thr Ser His 
                645                 650                 655     


Leu Asn Asn Asp Val Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys 
            660                 665                 670         


Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Gly Ser 
        675                 680                 685             


Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His Met Ala Arg 
    690                 695                 700                 


Gly Leu Lys Tyr Leu His Gln 
705                 710     


<210>  38
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  38

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr 
385                 390                 395                 400 


Glu Met Arg Arg His Gly Thr Thr His Ser Leu Val Ile His Asp Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Cys His Trp Asn Asp 
            420                 425                 430         


Leu Ala Val Ile Pro Ala Gly Val Val His Asn Trp Asp Phe Glu Pro 
        435                 440                 445             


Arg Lys Val Ser 
    450         


<210>  39
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  39

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Ser 
            340                 345                 350         


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
        355                 360                 365             


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Phe 
    370                 375                 380                 


Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Ala Met Asp Glu 
385                 390                 395                 400 


Met Glu Phe Thr Glu Ala Glu Ser Asn Met Gly Gly Gly Gly Ser Pro 
                405                 410                 415     


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
            420                 425                 430         


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
    450                 455                 460                 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Val 
465                 470                 475                 480 


Val Asp Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu Met 
                485                 490                 495     


Lys Gly Leu Cys Glu Lys Pro Leu Ala Ser Gly Gly Gly Gly Ser Glu 
            500                 505                 510         


Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly 
        515                 520                 525             


Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly Gly Ser Asp 
    530                 535                 540                 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
545                 550                 555                 560 


Met Ala Arg Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Ser 
                565                 570                 575     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            580                 585                 590         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
    610                 615                 620                 


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Arg 
625                 630                 635                 640 


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
                645                 650                 655     


Gly Thr Thr His Ser Leu Val Ile His Asp 
            660                 665     


<210>  40
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  40

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly 
385                 390                 395                 400 


Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            420                 425                 430         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser 
        435                 440         


<210>  41
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  41

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Ser 
    370                 375                 380                 


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
385                 390                 395                 400 


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Arg 
                405                 410                 415     


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
            420                 425                 430         


Gly Thr Thr His Ser Leu Val Ile His Asp 
        435                 440         


<210>  42
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  42

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Arg 
    370                 375                 380                 


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
385                 390                 395                 400 


Gly Thr Thr His Ser Leu Val Ile His Asp Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            420                 425                 430         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
    450                 455                 460                 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met Phe Thr 
                485                 490                 495     


Ala Thr Met Pro Pro Ala Val Glu Arg Leu Gly Gly Gly Gly Ser Val 
            500                 505                 510         


Val Asp Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu Met 
        515                 520                 525             


Lys Gly Leu Cys Glu Lys Pro Leu Ala Ser Gly Gly Gly Gly Ser Ser 
    530                 535                 540                 


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
545                 550                 555                 560 


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Glu 
                565                 570                 575     


Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly 
            580                 585                 590         


Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    610                 615                 620                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                645                 650                 655     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln 
            660                 665     


<210>  43
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  43

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Arg 
    370                 375                 380                 


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
385                 390                 395                 400 


Gly Thr Thr His Ser Leu Val Ile His Asp Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            420                 425                 430         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
    450                 455                 460                 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met Phe Thr 
                485                 490                 495     


Ala Thr Met Pro Pro Ala Val Glu Arg Leu Gly Gly Gly Gly Ser Val 
            500                 505                 510         


Val Asp Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu Met 
        515                 520                 525             


Lys Gly Leu Cys Glu Lys Pro Leu Ala Ser Gly Gly Gly Gly Ser Ser 
    530                 535                 540                 


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
545                 550                 555                 560 


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Glu 
                565                 570                 575     


Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly 
            580                 585                 590         


Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    610                 615                 620                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                645                 650                 655     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Pro 
            660                 665                 670         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        675                 680                 685             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Arg 
    690                 695                 700                 


Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His 
705                 710                 715                 720 


Gly Thr Thr His Ser Leu Val Ile His Asp Gly Gly Gly Gly Ser Ser 
                725                 730                 735     


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
            740                 745                 750         


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
        755                 760                 765             


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
    770                 775                 780                 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ala 
785                 790                 795                 800 


Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met Phe Thr 
                805                 810                 815     


Ala Thr Met Pro Pro Ala Val Glu Arg Leu Gly Gly Gly Gly Ser Val 
            820                 825                 830         


Val Asp Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu Met 
        835                 840                 845             


Lys Gly Leu Cys Glu Lys Pro Leu Ala Ser Gly Gly Gly Gly Ser Ser 
    850                 855                 860                 


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
865                 870                 875                 880 


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Glu 
                885                 890                 895     


Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly 
            900                 905                 910         


Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly Gly Ser Ser 
        915                 920                 925             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    930                 935                 940                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
945                 950                 955                 960 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                965                 970                 975     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln 
            980                 985     


<210>  44
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  44

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Ser 
            340                 345                 350         


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
        355                 360                 365             


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
385                 390                 395                 400 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
            420                 425                 430         


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Ser 
        435                 440                 445             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    450                 455                 460                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
465                 470                 475                 480 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                485                 490                 495     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Ser 
            500                 505                 510         


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
        515                 520                 525             


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
545                 550                 555                 560 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ser 
                565                 570                 575     


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
            580                 585                 590         


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    610                 615                 620                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                645                 650                 655     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln 
            660                 665     


<210>  45
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  45

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Ser 
            340                 345                 350         


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
        355                 360                 365             


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
385                 390                 395                 400 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ser 
                405                 410                 415     


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
            420                 425                 430         


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Ser 
        435                 440                 445             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    450                 455                 460                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
465                 470                 475                 480 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                485                 490                 495     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Ser 
            500                 505                 510         


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
        515                 520                 525             


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
545                 550                 555                 560 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ser 
                565                 570                 575     


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
            580                 585                 590         


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    610                 615                 620                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                645                 650                 655     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Ser 
            660                 665                 670         


His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His 
        675                 680                 685             


Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Gly Gly Gly Gly Ser Gly 
    690                 695                 700                 


Arg Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val 
705                 710                 715                 720 


Leu Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Ser 
                725                 730                 735     


Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe 
            740                 745                 750         


Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Ser 
        755                 760                 765             


Thr Ala Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile 
    770                 775                 780                 


Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Gly Gly Gly Gly Ser Asp 
785                 790                 795                 800 


Ser Gly Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His 
                805                 810                 815     


Met Ala Arg Gly Leu Lys Tyr Leu His Gln 
            820                 825     


<210>  46
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB construct

<400>  46

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr 
385                 390                 395                 400 


Glu Met Arg Arg His Gly Thr Thr His Ser Leu Val Ile His Asp Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Cys His Trp Asn Asp 
            420                 425                 430         


Leu Ala Val Ile Pro Ala Gly Val Val His Asn Trp Asp Phe Glu Pro 
        435                 440                 445             


Arg Lys Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg 
    450                 455                 460                 


Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val Leu 
465                 470                 475                 480 


Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu 
            500                 505                 510         


Ala Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Val Val Asp Arg Asn Pro Gln Phe 
    530                 535                 540                 


Leu Asp Pro Val Leu Ala Tyr Leu Met Lys Gly Leu Cys Glu Lys Pro 
545                 550                 555                 560 


Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Pro 
                565                 570                 575     


Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe Thr Tyr 
            580                 585                 590         


Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn 
    610                 615                 620                 


Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Ser Thr Ala Asn Tyr Asn Thr Ser His 
                645                 650                 655     


Leu Asn Asn Asp Val Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys 
            660                 665                 670         


Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Gly Ser 
        675                 680                 685             


Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His Met Ala Arg 
    690                 695                 700                 


Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Ala Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met 
                725                 730                 735     


Phe Thr Ala Thr Met Pro Pro Ala Val Glu Arg Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asn His Ser Gly Leu Val Thr Phe Gln Ala 
        755                 760                 765             


Phe Ile Asp Val Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp 
    770                 775                 780                 


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Gly Thr Ala Phe 
785                 790                 795                 800 


Phe Ile Asn Phe Ile Ala Ile Tyr His His Ala Ser Arg Ala Ile Pro 
                805                 810                 815     


Phe Gly Thr Met Val Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            820                 825                 830         


Phe Val Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr 
        835                 840                 845             


Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala Gly Gly Gly Gly Ser 
    850                 855                 860                 


Gly Gly Gly Gly Ser Thr Pro Pro Pro Glu Glu Ala Met Pro Phe Glu 
865                 870                 875                 880 


Phe Asn Gly Pro Ala Gln Gly Asp His Ser Gln Pro Pro Leu Gln Val 
                885                 890                 895     


<210>  47
<211>  1081
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB vector

<400>  47

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro 
        355                 360                 365             


Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr 
385                 390                 395                 400 


Glu Met Arg Arg His Gly Thr Thr His Ser Leu Val Ile His Asp Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Cys His Trp Asn Asp 
            420                 425                 430         


Leu Ala Val Ile Pro Ala Gly Val Val His Asn Trp Asp Phe Glu Pro 
        435                 440                 445             


Arg Lys Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg 
    450                 455                 460                 


Gly His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val Leu 
465                 470                 475                 480 


Leu Gly Arg Lys Val Val Val Val Arg Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu 
            500                 505                 510         


Ala Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Val Val Asp Arg Asn Pro Gln Phe 
    530                 535                 540                 


Leu Asp Pro Val Leu Ala Tyr Leu Met Lys Gly Leu Cys Glu Lys Pro 
545                 550                 555                 560 


Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Pro 
                565                 570                 575     


Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe Thr Tyr 
            580                 585                 590         


Leu Arg Leu Lys Asp Asn Tyr Met Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn 
    610                 615                 620                 


Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly Met Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Ser Thr Ala Asn Tyr Asn Thr Ser His 
                645                 650                 655     


Leu Asn Asn Asp Val Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys 
            660                 665                 670         


Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Gly Ser 
        675                 680                 685             


Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His Met Ala Arg 
    690                 695                 700                 


Gly Leu Lys Tyr Leu His Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Ala Asn Phe Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met 
                725                 730                 735     


Phe Thr Ala Thr Met Pro Pro Ala Val Glu Arg Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asn His Ser Gly Leu Val Thr Phe Gln Ala 
        755                 760                 765             


Phe Ile Asp Val Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp 
    770                 775                 780                 


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Gly Thr Ala Phe 
785                 790                 795                 800 


Phe Ile Asn Phe Ile Ala Ile Tyr His His Ala Ser Arg Ala Ile Pro 
                805                 810                 815     


Phe Gly Thr Met Val Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            820                 825                 830         


Phe Val Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr 
        835                 840                 845             


Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala Gly Gly Gly Gly Ser 
    850                 855                 860                 


Gly Gly Gly Gly Ser Thr Pro Pro Pro Glu Glu Ala Met Pro Phe Glu 
865                 870                 875                 880 


Phe Asn Gly Pro Ala Gln Gly Asp His Ser Gln Pro Pro Leu Gln Val 
                885                 890                 895     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Lys Pro Asp Phe Ser 
            900                 905                 910         


Gln Leu Gln Arg Asn Ile Leu Pro Ser Asn Pro Arg Val Thr Arg Phe 
        915                 920                 925             


His Ile Asn Trp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
    930                 935                 940                 


Pro Ser Gly Thr Thr Ile Leu Asn Cys Phe His Asp Val Leu Ser Gly 
945                 950                 955                 960 


Lys Leu Ser Gly Gly Ser Pro Gly Val Pro Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Phe Ser Gln Pro Leu Arg Arg Leu Val Leu His 
            980                 985                 990         


Val Val Ser Ala Ala Gln Ala Glu  Arg Leu Ala Arg Ala  Glu Glu Gly 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Glu Cys Arg  Ile Thr Ser 
    1010                 1015                 1020             


Asn Phe  Val Ile Pro Ser Glu  Tyr Trp Val Glu Glu  Lys Glu Glu 
    1025                 1030                 1035             


Lys Gln  Lys Leu Ile Gln Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1040                 1045                 1050             


Ser Asn  Ile Glu Gly Ile Asp  Lys Leu Thr Gln Leu  Lys Lys Pro 
    1055                 1060                 1065             


Phe Leu  Val Asn Asn Lys Ile  Asn Lys Ile Glu Asn  Ile 
    1070                 1075                 1080     


<210>  48
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB construct

<400>  48

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Val 
            340                 345                 350         


Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln 
        355                 360                 365             


Pro Ala Gln Ala Gln Met Leu Thr Pro Pro Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Leu His Ser Gly Gln Asn His Leu Lys Glu Met Ala 
385                 390                 395                 400 


Ile Ser Val Leu Glu Ala Arg Ala Cys Ala Ala Ala Gly Gln Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Leu Leu Pro Phe Tyr Pro 
            420                 425                 430         


Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu Leu Asn Ser Ser Ala Leu 
        435                 440                 445             


Pro Pro Thr Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly 
    450                 455                 460                 


Thr Gln Cys Glu Tyr Trp Ala Ser Arg Ala Leu Asp Ser Glu His Ser 
465                 470                 475                 480 


Ile Gly Ser Met Ile Gln Leu Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Ala Tyr Lys Gly His His Tyr Pro Gly Pro Gly Asn 
            500                 505                 510         


Tyr Phe Trp Lys Cys Leu Phe Met Ser Gly Leu Ser Glu Val Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Leu Ser Ala Met Ser Asn 
    530                 535                 540                 


Pro Arg Ala Met Gln Val Leu Leu Gln Ile Gln Gln Gly Leu Gln Thr 
545                 550                 555                 560 


Leu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Pro 
                565                 570                 575     


Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile Cys Gly 
            580                 585                 590         


Met Pro Leu Asp Ser Phe Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile 
    610                 615                 620                 


Ala Ile Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro His Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Tyr Ile Ser Arg Val Thr Ala Gly 
                645                 650                 655     


Lys Asp Ser Tyr Ile Ala Leu Val Asp Lys Asn Ile Met Gly Tyr Ile 
            660                 665                 670         


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu His Ile His 
        675                 680                 685             


Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val Gly Phe Gly 
    690                 695                 700                 


Arg Ile Gly Lys His Phe Trp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Gln Ala Ile Val Arg Gly Cys Ser Met Pro Gly Pro Trp Arg Ser 
                725                 730                 735     


Gly Arg Leu Leu Val Ser Arg Arg Trp Ser Val Glu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asp Gly Gln Leu Glu Leu Leu Ala Gln Gly 
        755                 760                 765             


Ala Leu Asp Asn Ala Leu Ser Ser Met Gly Ala Leu His Ala Leu Arg 
    770                 775                 780                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Asp Ser Arg 
785                 790                 795                 800 


Lys Ser Thr Ser Phe Met Ser Val Asn Pro Ser Lys Glu Ile Lys Ile 
                805                 810                 815     


Val Ser Ala Val Arg Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            820                 825                 830         


His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Ile Lys Arg 
        835                 840                 845             


Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Gly Gly Gly Gly Ser 
    850                 855                 860                 


Gly Gly Gly Gly Ser Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala Lys 
865                 870                 875                 880 


Thr Gly Phe Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr Glu 
                885                 890                 895     


<210>  49
<211>  1081
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB construct

<400>  49

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Ile Glu Pro Lys Ser Cys Asp 
            100                 105                 110         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu 
225                 230                 235                 240 


Gly Gly Leu Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                245                 250                 255     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn 
            260                 265                 270         


Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala 
        275                 280                 285             


Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
    290                 295                 300                 


Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
305                 310                 315                 320 


Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                325                 330                 335     


Cys Ser Gln Lys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Val 
            340                 345                 350         


Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln 
        355                 360                 365             


Pro Ala Gln Ala Gln Met Leu Thr Pro Pro Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Leu His Ser Gly Gln Asn His Leu Lys Glu Met Ala 
385                 390                 395                 400 


Ile Ser Val Leu Glu Ala Arg Ala Cys Ala Ala Ala Gly Gln Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Leu Leu Pro Phe Tyr Pro 
            420                 425                 430         


Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu Leu Asn Ser Ser Ala Leu 
        435                 440                 445             


Pro Pro Thr Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly 
    450                 455                 460                 


Thr Gln Cys Glu Tyr Trp Ala Ser Arg Ala Leu Asp Ser Glu His Ser 
465                 470                 475                 480 


Ile Gly Ser Met Ile Gln Leu Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Ala Tyr Lys Gly His His Tyr Pro Gly Pro Gly Asn 
            500                 505                 510         


Tyr Phe Trp Lys Cys Leu Phe Met Ser Gly Leu Ser Glu Val Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Leu Ser Ala Met Ser Asn 
    530                 535                 540                 


Pro Arg Ala Met Gln Val Leu Leu Gln Ile Gln Gln Gly Leu Gln Thr 
545                 550                 555                 560 


Leu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Pro 
                565                 570                 575     


Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile Cys Gly 
            580                 585                 590         


Met Pro Leu Asp Ser Phe Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile 
    610                 615                 620                 


Ala Ile Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro His Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Tyr Ile Ser Arg Val Thr Ala Gly 
                645                 650                 655     


Lys Asp Ser Tyr Ile Ala Leu Val Asp Lys Asn Ile Met Gly Tyr Ile 
            660                 665                 670         


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu His Ile His 
        675                 680                 685             


Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val Gly Phe Gly 
    690                 695                 700                 


Arg Ile Gly Lys His Phe Trp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Gln Ala Ile Val Arg Gly Cys Ser Met Pro Gly Pro Trp Arg Ser 
                725                 730                 735     


Gly Arg Leu Leu Val Ser Arg Arg Trp Ser Val Glu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asp Gly Gln Leu Glu Leu Leu Ala Gln Gly 
        755                 760                 765             


Ala Leu Asp Asn Ala Leu Ser Ser Met Gly Ala Leu His Ala Leu Arg 
    770                 775                 780                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser His Asp Ser Arg 
785                 790                 795                 800 


Lys Ser Thr Ser Phe Met Ser Val Asn Pro Ser Lys Glu Ile Lys Ile 
                805                 810                 815     


Val Ser Ala Val Arg Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            820                 825                 830         


His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Ile Lys Arg 
        835                 840                 845             


Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Gly Gly Gly Gly Ser 
    850                 855                 860                 


Gly Gly Gly Gly Ser Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala Lys 
865                 870                 875                 880 


Thr Gly Phe Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr Glu 
                885                 890                 895     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Gly Asp Pro Cys Leu 
            900                 905                 910         


Arg Ser Ser Asp Cys Ile Asp Glu Phe Cys Cys Ala Arg His Phe Trp 
        915                 920                 925             


Thr Lys Ile Cys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp 
    930                 935                 940                 


Lys Gly Gly Pro Val Lys Ile Asp Pro Leu Ala Leu Met Gln Ala Ile 
945                 950                 955                 960 


Glu Arg Tyr Leu Val Val Arg Gly Tyr Gly Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Val Thr Ser Ile Pro Ser Val Ser Asn Ala Leu Asn 
            980                 985                 990         


Trp Lys Glu Phe Ser Phe Ile Gln  Ser Thr Leu Gly Tyr  Val Ala Gly 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Tyr Arg Gly  Ala Asn Leu 
    1010                 1015                 1020             


His Leu  Glu Glu Thr Leu Ala  Gly Phe Trp Ala Arg  Leu Leu Glu 
    1025                 1030                 1035             


Arg Leu  Phe Lys Gln Leu Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1040                 1045                 1050             


Ser Lys  Thr Thr Leu Ser His  Thr Gln Asp Ser Ser  Gln Ser Leu 
    1055                 1060                 1065             


Gln Ser  Ser Ser Asp Ser Ser  Lys Ser Ser Arg Cys  Ser 
    1070                 1075                 1080     


<210>  50
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  50

Gln Ala Ile Val Arg Gly Cys Ser Met Pro Gly Pro Trp Arg Ser Gly 
1               5                   10                  15      


Arg Leu Leu Val Ser Arg Arg Trp Ser Val Glu 
            20                  25          


<210>  51
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  51

Asp Gly Gln Leu Glu Leu Leu Ala Gln Gly Ala Leu Asp Asn Ala Leu 
1               5                   10                  15      


Ser Ser Met Gly Ala Leu His Ala Leu Arg Pro 
            20                  25          


<210>  52
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  52

Ser His Asp Ser Arg Lys Ser Thr Ser Phe Met Ser Val Asn Pro Ser 
1               5                   10                  15      


Lys Glu Ile Lys Ile Val Ser Ala Val Arg Arg 
            20                  25          


<210>  53
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  53

His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Ile Lys Arg 
1               5                   10                  15      


Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg 
            20                  25          


<210>  54
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  54

Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala Lys Thr Gly Phe Thr Lys 
1               5                   10                  15      


Leu Ile Asp Ala Ser Arg Val Ser Glu Thr Glu 
            20                  25          


<210>  55
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  55

Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Asp Glu Phe Cys 
1               5                   10                  15      


Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25          


<210>  56
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  56

Trp Lys Gly Gly Pro Val Lys Ile Asp Pro Leu Ala Leu Met Gln Ala 
1               5                   10                  15      


Ile Glu Arg Tyr Leu Val Val Arg Gly Tyr Gly 
            20                  25          


<210>  57
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  57

Val Thr Ser Ile Pro Ser Val Ser Asn Ala Leu Asn Trp Lys Glu Phe 
1               5                   10                  15      


Ser Phe Ile Gln Ser Thr Leu Gly Tyr Val Ala 
            20                  25          


<210>  58
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  58

Tyr Arg Gly Ala Asn Leu His Leu Glu Glu Thr Leu Ala Gly Phe Trp 
1               5                   10                  15      


Ala Arg Leu Leu Glu Arg Leu Phe Lys Gln Leu 
            20                  25          


<210>  59
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  59

Lys Thr Thr Leu Ser His Thr Gln Asp Ser Ser Gln Ser Leu Gln Ser 
1               5                   10                  15      


Ser Ser Asp Ser Ser Lys Ser Ser Arg Cys Ser 
            20                  25          


<210>  60
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  60

Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Val Met Ser 
1               5                   10                  15      


Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln 
            20                  25          


<210>  61
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  61

Cys Gly Thr Ala Phe Phe Ile Asn Phe Ile Ala Ile Tyr His His Ala 
1               5                   10                  15      


Ser Arg Ala Ile Pro Phe Gly Thr Met Val Ala 
            20                  25          


<210>  62
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  62

Phe Val Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr 
1               5                   10                  15      


Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala 
            20                  25          


<210>  63
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  63

Thr Pro Pro Pro Glu Glu Ala Met Pro Phe Glu Phe Asn Gly Pro Ala 
1               5                   10                  15      


Gln Gly Asp His Ser Gln Pro Pro Leu Gln Val 
            20                  25          


<210>  64
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  64

Pro Lys Pro Asp Phe Ser Gln Leu Gln Arg Asn Ile Leu Pro Ser Asn 
1               5                   10                  15      


Pro Arg Val Thr Arg Phe His Ile Asn Trp Asp 
            20                  25          


<210>  65
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  65

Ile Pro Ser Gly Thr Thr Ile Leu Asn Cys Phe His Asp Val Leu Ser 
1               5                   10                  15      


Gly Lys Leu Ser Gly Gly Ser Pro Gly Val Pro 
            20                  25          


<210>  66
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  66

Gly Phe Ser Gln Pro Leu Arg Arg Leu Val Leu His Val Val Ser Ala 
1               5                   10                  15      


Ala Gln Ala Glu Arg Leu Ala Arg Ala Glu Glu 
            20                  25          


<210>  67
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  67

Glu Cys Arg Ile Thr Ser Asn Phe Val Ile Pro Ser Glu Tyr Trp Val 
1               5                   10                  15      


Glu Glu Lys Glu Glu Lys Gln Lys Leu Ile Gln 
            20                  25          


<210>  68
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  68

Asn Ile Glu Gly Ile Asp Lys Leu Thr Gln Leu Lys Lys Pro Phe Leu 
1               5                   10                  15      


Val Asn Asn Lys Ile Asn Lys Ile Glu Asn Ile 
            20                  25          


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Gly Gly Gly Ser Ser 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Gly Gly Gly Ser Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Leu Gly Gly Gly Ser 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  73

Gly Leu Gly Gly Ser 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  74

Gly Gly Leu Gly Ser 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  75

Gly Gly Gly Leu Ser 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  76

Gly Gly Gly Gly Leu 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  77

Leu Gly Gly Ser Gly 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  78

Gly Leu Gly Ser Gly 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  79

Gly Gly Leu Ser Gly 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  80

Gly Gly Gly Leu Gly 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  81

Gly Gly Gly Ser Leu 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  82

Leu Gly Gly Ser Ser 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  83

Gly Leu Gly Ser Ser 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  84

Gly Gly Leu Ser Ser 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  85

Gly Gly Gly Leu Ser 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  86

Gly Gly Gly Ser Leu 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  87

Leu Gly Leu Gly Ser 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  88

Gly Leu Gly Leu Ser 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  89

Gly Leu Leu Gly Ser 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  90

Leu Gly Gly Leu Ser 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  91

Gly Leu Gly Gly Leu 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Leu Gly Leu Ser Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  93

Gly Leu Leu Ser Gly 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  94

Gly Gly Leu Ser Leu 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  95

Gly Gly Leu Leu Gly 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  96

Gly Leu Gly Ser Leu 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  97

Leu Gly Leu Ser Ser 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  98

Gly Leu Gly Leu Ser 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  99

Gly Gly Leu Leu Ser 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  100

Gly Leu Gly Ser Leu 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  101

Gly Leu Gly Ser Leu 
1               5   


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  102

Leu Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  103

Gly Leu Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  104

Gly Gly Leu Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  105

Gly Gly Gly Leu Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  106

Gly Gly Gly Gly Leu Gly Gly Gly Gly Ser 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  107

Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  108

Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  109

Gly Gly Leu Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  110

Gly Gly Gly Leu Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  111

Gly Gly Gly Ser Leu Gly Gly Gly Ser Gly 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  112

Gly Gly Gly Ser Leu Gly Gly Gly Ser Gly 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  113

Gly Leu Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  114

Gly Gly Leu Ser Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  115

Gly Gly Gly Leu Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  116

Gly Gly Gly Ser Leu Gly Gly Gly Ser Ser 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  117

Leu Gly Gly Gly Ser Leu Gly Gly Gly Ser 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  118

Gly Leu Gly Gly Ser Gly Leu Gly Gly Ser 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  119

Gly Gly Leu Gly Ser Gly Gly Leu Gly Ser 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  120

Gly Gly Gly Leu Ser Gly Gly Gly Leu Ser 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  121

Gly Gly Gly Gly Leu Gly Gly Gly Gly Leu 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  122

Leu Gly Gly Ser Gly Leu Gly Gly Ser Gly 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  123

Gly Leu Gly Ser Gly Gly Leu Gly Ser Gly 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  124

Gly Gly Leu Ser Gly Gly Gly Leu Ser Gly 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  125

Gly Gly Gly Leu Gly Gly Gly Gly Leu Gly 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  126

Gly Gly Gly Ser Leu Gly Gly Gly Ser Leu 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  127

Leu Gly Gly Ser Ser Leu Gly Gly Ser Ser 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  128

Gly Leu Gly Ser Ser Gly Leu Gly Ser Ser 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  129

Gly Gly Leu Ser Ser Gly Gly Leu Ser Ser 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  130

Gly Gly Gly Leu Ser Gly Gly Gly Leu Ser 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  131

Gly Gly Gly Ser Leu Gly Gly Gly Ser Leu 
1               5                   10  


