                         SEQUENCE LISTING

<110>  Universiteit Gent
 
<120>  Vaccine strains of brachyspira hyodysenteriae

<130>  P2015/061 PCT

<150>  EP16150392.5
<151>  2016-01-07

<150>  EP16170374.9
<151>  2016-05-19

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  1272
<212>  DNA
<213>  Brachyspira

<400>  1
atgcgtttag taagagaaaa aaaaataaaa gaagaggata aaaagtattg ggaaaaatca       60

agttctatga tacctaccct attagttggc aataacatag taaatatatc tgcgagttct      120

attataacag tatttgcagt aaggcttgct gatattctgc cgcatgtatc aacaaatata      180

atggttacaa tatcaactgc tacaataaca atacttatta ttatatttgg tgaaatactg      240

ccaaaagtct taatgagagt aaatgctgaa aaagtaatgc cttatctttt atactttatg      300

aaattttgcc attttatatt caagcctata acctttttaa tggataaagt aactactttt      360

ataatgaatt atttcgttcc taaaagatta agagatgctg aaaaaagaag tgcattatca      420

agtatggacg atataacaac aataatacat ttggggcata aagaaggtat aataaaagaa      480

tatacacatg aaatgcttac aggtgtaata gatttcagaa ataaaactgt agaagaaata      540

atgactcctc gtgttgatat ggtatgtatt gaggctgaaa ctgatgtaaa tgaaataata      600

aaacttactg tagaaacagg gctttcaaga tttccggttt atgaggaaac tgttgatcat      660

ataataggaa ttttccatac tagagcttta tttaaagagt atgttaaagg cggcggaaaa      720

atgaataaaa taaaaaagaa agcaatagat tatataatgc ttccctactt tgtacctgaa      780

actaaaacta taagcagctt atttagtgat atgcaaaaga aaaaacttca gatggtaatt      840

actattgatg aatacggcgg aactgctggg cttgttacta tggaagatat aatagaagag      900

ataatgggtg atatagaaga tgaaagtgat aaaaaagaag ctgatgtaat aagatttaag      960

ggaaaaagaa ttataataaa tggaaatgct tctatagaag atgtcaacaa aactttaaaa     1020

ttagaattag agcatgaaga atatcaaact atagcaggat atgttattga tatgcttgat     1080

catatacctg aaacaaatga gagattcata ttaaaaggat atagagtaag aataatgaaa     1140

gttgaagaca gaagaatagt tgaaatggaa tttactccta taaaatttgc aagaacaaat     1200

gaaagtgata atattgatat acaagagaca tctgattcag aaaaaaatga tttagaaatt     1260

ttaaatgaat aa                                                         1272


<210>  2
<211>  612
<212>  DNA
<213>  Brachyspira

<400>  2
atggagaaaa gtgcttttta tatagatata caaaacaaat ctaataaatc aaaaaagata       60

ggggagctat actcagcaat atcccatggc ataggagctt tacttggtat tgctggactt      120

gttcttatgc ttgtaaaaat aaaaatgaat cctataccta taattattta tggagttggt      180

ataatctttt tatatacatt cagttcttta tatcatttct ttcctgacgg taaaataaaa      240

caaatattta gaaaatttga tcacatagga atatatgtgt ttatagccgc aacttatact      300

ccagtttgta tattttcact tcctagaaac ataggaatac caatattatc agtaatatgg      360

tcttgtgctt tgataggtat attatctaat acagttataa aatataaaaa tattgttcta      420

aggctagttt tatatatatt aatgggctgg ataataatat ttgcattcaa accattaatg      480

aatagatttg atattttgca tttaaattgg cttatatggg gaggaatatt ttatactata      540

ggtgctttct tatatgcttt aggtaaaaaa tgcaatgata aaactaagca attcactcat      600

gatattttcc at                                                          612


<210>  3
<211>  672
<212>  DNA
<213>  Brachyspira

<400>  3
atgaatgctg atttgaataa taatatagta aagaattctg tttctaagat aagcgctgtt       60

atatgcataa tatgtgctag ttcggcaata gctgtcttag tgcttttaat aattaattct      120

aaaactgcaa gggaaattac ttcattttct ctatactcaa gttttttaac aatattttat      180

ataataaatt cgatatatca tttttttcct tttaacaata aagcaaaaaa agttttttat      240

atattatccc atgcattttt tattatgatg atatggggta tatacattcc tccatgccta      300

atatcattac aaaatggatg gggatggagt ttctttggta ttattacagg tttatgtgca      360

ttaggcatca cattaagaag cgtattcgga tacagatggc gtggtgctac agaaactata      420

tattattttc tattaaattg ggtttggctt atagcaattt caaaaatatc tactgctgta      480

ggtgaatatg gagcaatatt atatttaaca ggttttcttc tgctcaatat agcaatggta      540

ttttacagac tcgctatgta tgaagccaat agaagatata ctttattttt acctttattt      600

tattcgcttt taataatatc aaatatatgc catgcagtat ttatgtttag atatgttgct      660

aacattttct aa                                                          672


<210>  4
<211>  925
<212>  DNA
<213>  Brachyspira

<400>  4
tatactgaaa cttttgaatc agtttatata acttcaaata tattagaaag caatcatact       60

caaatgcttt taaaagtaaa tatgagagat aaagaaagaa attctctttc tataataaaa      120

tctttccttg gattataata ctaatataaa tgcgattaga tgaatatgtg catagtgaat      180

gctatacaga aagcagatct aaagcacagg atataatact agccggttgt gtttttgtta      240

atggagtaaa ggtaacttct aaggctcata aaataaaaga tactgataat atagaagttg      300

ttcagaatat aaaatatgta tcaagagctg gagaaaaatt agaaaaggcg tttgtagaat      360

ttggaatatc tgtagaaaat aaaatatgtt tagatatagg agcttctaca ggaggattta      420

cagattgtct gcttaagcat ggtgctaaaa aagtttatgc tcttgatgta ggacataatc      480

agctagttta taaacttcgt aatgataata gggtagtgtc aatagaagat ttcaatgcca      540

aagatataaa taaagaaatg ttcaatgatg aaatcccatc tgtaatagta agtgacgtat      600

catttatatc aataacaaaa atagcaccaa tcatatttaa agaattaaat aatttagagt      660

tttgggtaac tttaataaaa ccacaatttg aagctgaaag aggtgatgtt tcaaaaggcg      720

gtataatacg agatgatata cttagagaaa aaatattaaa taatgctatt tcaaagataa      780

tagactgcgg atttaaagaa gttaatagaa ccatctctcc tataaaaggt gctaaaggta      840

atatagaata tttagctcat tttattattt aatcattttc tattttatgt gtatttctct      900

gtttatatat ttcatattct ttata                                            925


<210>  5
<211>  2731
<212>  DNA
<213>  Brachyspira

<400>  5
taataaggac aattctcata agactaatac tgcatcatct agtaagacta acataaatgt       60

tgttaatgta gctaatagta gttttattta aaatttaaaa cctataatag aaattctaaa      120

ttatacatta gcattccttt atgttaatgt ataattttgt tttatttata atagtatttc      180

tattatatcc gataatgatt attaaaatat tttatatacg taaaatataa tacaggatta      240

taatatgttt caatttcatt taacaagcaa agcaaaaaag gtaatagaat tatatgctca      300

ggaagaagca aaaagattaa atcatgatat ggttacacct gaacatatac ttttggggct      360

tcttcatgaa tcagaggctt tggcaacacg tgttttgatg agattgaaaa ttgatttgga      420

cagacttaaa ttagaattag aatcagctat ggtaaaatct tcaactacaa aagtatttgg      480

aactttacct acagctccaa gagtacagaa acttataagc agatctgctg aagaggctag      540

ggctttaagt cataactata taggtactga acatttactt cttggacttc taagagaaga      600

aagtggtaca gcttataatg tacttacaag tatggggctt gagcttacta tattaagaca      660

agaaatatta aaaatgcttg gtgttgctgg aagtaatatt tcttctatgg aacagacaag      720

tcaggaagat aatgtaaaaa aggtaaaaac acctacttta gatcaatttg ccagagattt      780

aactaaaatg gctagagaca aggctttaga cagagttata ggcagagaaa atgaagtaat      840

gagagttgtt cagattttat caagaagaaa gaaaaataat cctatacttc ttggtgagcc      900

tggtgtaggt aaaacagcta tagtagaggg acttgctgaa aagatagtag ctgctgatgt      960

acctgatata cttctaaaaa aacgtgtatt aactttagat ttgtcttcag ttgttgctgg     1020

tacaaaatac agaggtgaat ttgaagagag aataaaaaac atagttttag aaataaaaaa     1080

agctagtaat attattatat tcatagatga gcttcataca ttaatagggg caggtggtgc     1140

tgaaggtgct ttagatgctg ctaatatgtt aaagccggca ctttcaagag gcgagattca     1200

atgtataggt gccactacta taaatgaata taaaaaatat atagaaaaag acggtgcttt     1260

ggttagaaga ttccagccta taaatgttga agagcctagt atagaggata ctattgaaat     1320

attgaatggt atcaaaggta aatatgaaga acatcataaa gtaaaatata ctgatgaagc     1380

aataaatgct gctactgtat tgagtaagag atatattttt gaaagacatt tgcctgataa     1440

agctatagac ttaatagatg aggcaggttc aagagcaaga cttcttaata tgacaagacc     1500

tcaggagttt aaagatttag aaaagaaaat agaagagctt aatcagcaaa agaaaagagt     1560

tgttgagagt cagaatttcg aagatgctgc taaaataaga gatgaaatta cttctttaca     1620

ggaagagctt tctaaaaaag aagaaaaatg gcgtgaagaa agagaaaaga tagaaacatt     1680

tattgaagaa gatgatataa gacatgttat atcagaaata actaatatac ctataaaaag     1740

attattaaac tcagaaagta aaagacttat aggtatggaa gaagaattgc atcagaaagt     1800

cgtaggacag aaagaagcta tatcttctat atctaaggct ataagaagaa gcagagcagg     1860

acttaaaaca tcaaaaagac ctcttggaag ttttattttc ctgggaccta caggtgttgg     1920

taaaactgct ttagctaaag ttctttcaga gtttatgttt ggagacagcg atgctcttat     1980

cagaatagat atgagtgagt ttatggaaaa gtttgcggta agcagactta taggagctcc     2040

tcctggatat gttggttatg aagagggagg cggacttact gaaaaggtga gaagaaagcc     2100

ttattctctt atactttttg atgaaataga aaaagctcat cctgatgtta ctaatatact     2160

tttacaagta cttgaagaag gacagcttac tgataatttt ggaagaaaag ttgatttttc     2220

aaatactatt ataataataa caagtaactt aggtgcaaga gatattgtaa aaggaagttc     2280

tttaggattt aatgctgttg gaagcgaaaa agatgctaat gatattaaaa attttgcttt     2340

agaagaatta aaacagaatt ttaatcctga gtttttaaat agaattgatg atatcatagt     2400

attccatact ttaagtaaag aggatttgaa agatattatt aatataatgc ttaaagagct     2460

taatgaagct attaaagaaa gaaatattgt tattaattta agcgaagaag ctaagaatta     2520

tatcatagat aaaggattcg ataagaagta tggtgctaga agtttaagaa gggctataca     2580

gaaagagata gaggattatg tgagtaccga aatattattc ggtaatattg aagatggtga     2640

tactattaac gttgatgcta atgatggctc tttgatattt tcttatgata agtcagttaa     2700

gactgagaat aaggaattat ctaaaagtta g                                    2731


<210>  6
<211>  934
<212>  DNA
<213>  Brachyspira

<400>  6
taaaagggat acatcataat tatactagaa aatcattaat ggaaaataat aagaaaatga       60

aggaattata caaaaaagtg ataaaaacaa taaaagaaaa taaatcataa tttaaggata      120

tatataaaat gccaataaaa aaattaatat ctaagatagt gaaaaaaaaa gatagtgata      180

ctgaaaaaaa taattatata aatttatccg cattaacaga agcagaaaga gaaattataa      240

ctaatactat agaattgaaa tcaaagagcg taagagaaat aatggtgcct agggttgatg      300

ttgttatgat acctatggaa tcttcttatg ataaggttat aaaggctttt aatagagata      360

gaaattccag aattcctgta tacaaagacg gcatagatga tatagtaggg gttttgtatg      420

taaaagattt gattgatgca gaagaaaaaa atttctcact taaaaaaatt ctacataaac      480

ctttattcgt accaatatca atttcattaa tggaattatt aaaaaatttc agagaaaagc      540

aaattcatat tgctatggtt gttgatgaat atggcggatt ttctggtatt gtttctatgg      600

aagatgtgct tgagcagatt ataggtgata ttagagatga atacgatgaa gaagacgaag      660

aaataaagag caatgatgat ggaacatatt tagttgatgc aagaactaga atagatgatt      720

ttaataaata tgagatactt ccgcctatac cggatgatga ggcagataca gttggaggat      780

ttttattttc atacttgggc aggcttccta aaagaaatga ggatatagaa tataatggat      840

attcatttac tgtagttggt aaaagcggaa atattgttac taaaataaga atagaaaaat      900

taaaaaaaga taatacagca aaaaataaag atta                                  934


<210>  7
<211>  468
<212>  DNA
<213>  Brachyspira

<400>  7
cggttgacgg cggaatgtca atgtaattat aaaaaagtat ataatgtgtt taaaaacact       60

ttattaataa acaatataca atttaaggag aattaaaaat ggcattaatc gatgaaatta      120

aagatgttgt tgctaatcaa ttaaacatct cagacaaaag taaaatcact gatacagctt      180

ctttcgtaga tgatttaaac gctgattcac ttgatttagt agaattaatc atggaattag      240

aaaaacgtta tgaaatcaaa attcctcaag aagatcaaga aaaaatcaaa aatgtagctg      300

atgctgctaa atacattgaa gaacataaaa aataattata ctatttaaat ttcccgtaaa      360

tagaattatg tcttttacgg gaaatttttc gatatagttc aaaatcatag gagttttata      420

tatgagtgaa cgtagagttg taattacggg gcttggaata gtaagttc                   468


<210>  8
<211>  1005
<212>  DNA
<213>  Brachyspira

<400>  8
ctatgctagt cctgaaagtt tgagaggtga aggcatcgat gtttatatgg gacatgatgt       60

tactaaaata gactgggcta acaaaaaatt atgtgtaaaa gaactaaaaa caggaaaaga      120

gtttgaagac acttacgata aacttattct tgctactggt tcttggcctg taactcctcc      180

tatcgaaggc ttaaaacaag aaggaactac ttacggactt aaaaaaggta ttttcttctc      240

taagctttat cagcaaggac aagaaattat tgatgaaata gctaaaccag atgttaaaaa      300

agttatggta gttggtgctg gatacatagg tgttgaactt atagaagcat tcaaaaacca      360

tggtaaagaa gttatcttaa tggaagctat gcctagagtt atggctaact actttgataa      420

agaaatcact gatgaagctg aaaaaagaat caaagaagct ggcatagaaa tgcatttagg      480

tgaaactgtt aagaaatttg aaggtgatga cagagttaaa aaagttgtta ctgacaaagg      540

ttcttatgat gtagatatgg tagttatgtc tgttggtttc agacctaata atgaacttta      600

taaagattat ttagaaactt tacctaatgg tgctattgta gtagatacta ctatgaaaac      660

tactaaagat cctgatgtat ttgctatagg tgactgtgct actgtatatt caagagcttc      720

tgaaaaacaa gaatatattg ctttagctac taatgctgta agaatgggta ttgttgctgc      780

taataatgct ttaggaaaac atgttgaata ttgcggtact caaggttcta atgctatttg      840

tgtatttgga tacaatatgg cttctactgg ttggtctgaa gaaactgcta agaaaaaagg      900

attaaaagta aaatctaact tcttcaaaga ttctgaaaga ccagaattta tgcctactaa      960

tgaagatgtt ttagtaaaaa tcatttatga agaaggcagc agacg                     1005


<210>  9
<211>  1182
<212>  DNA
<213>  Brachyspira

<400>  9
cgcatatact cttgctacat aagtagagta gaggaaagga gcaatccgct ttacgatgag       60

cctgcggcct attagcctgt tggtggggta acggcctacc aaagctacga taggtagccg      120

acctgagagg gtgaccggcc acattgggac tgagatacgg cccagactcc tacgggaggc      180

agcagctgag aatcttccac aatggacgaa agtctgatgg agcgacatcg cgtgagggat      240

gaaggccttc gggttgtaaa cctcggaaat tatcgaagaa tgagtgacag tagataatgt      300

aagcctcggc taactacgtg ccagcagccg cggtaatacg taggaggcaa acgttgctcg      360

gatttactgg gcgtaaaggg tgagtaggcg gacttataag tctaaggtga aagaccgaag      420

ctcaacttcg gaaacgcctc ggatactgta agtcttggat attgtagggg atgatggaat      480

tctcggtgta gcggtggaat gcgcagatat cgagaggaac acctatagcg aaggcagtca      540

tctgggcatt tatcgacgct gaatcacgaa agctagggga gcaaacaggc ttagataccc      600

tggtagtcct agccgtaaac gttgtacact aggtgcttct atttaaatag gagtgccgta      660

gctaacgtct taagtgtacc gcctgaggag tatgcccgca agggtgaaac tcaaagaaat      720

tgacgggtcc ccgcacaagt ggtggagcat gtggtttaat tcgatgatac gcgaaaaacc      780

ttacctgggt ttgaattgta agatgaatga tttagagata agtcagaccg caaggacgtt      840

ttacataggt gctgcatggc tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg      900

caacgagcgc aaccctcacc ctttgttgct accgagtaat gtcgggcact cttaggggac      960

tgcctacgtt caagtaggag gaaggtgggg atgatgtcaa gtcctcatgg cccttatgtc     1020

cagggctaca cacgtgctac aatggcaagt acaaagagaa gcaagaccgc gaggtggagc     1080

aaaactcaaa aaagttgcct cagttcggat tggagtctga aactcgactc catgaagttg     1140

gaatcactag taatcgtaga tcagaacgct acggtgaata cg                        1182


<210>  10
<211>  423
<212>  PRT
<213>  Brachyspira

<400>  10

Met Arg Leu Val Arg Glu Lys Lys Ile Lys Glu Glu Asp Lys Lys Tyr 
1               5                   10                  15      


Trp Glu Lys Ser Ser Ser Met Ile Pro Thr Leu Leu Val Gly Asn Asn 
            20                  25                  30          


Ile Val Asn Ile Ser Ala Ser Ser Ile Ile Thr Val Phe Ala Val Arg 
        35                  40                  45              


Leu Ala Asp Ile Leu Pro His Val Ser Thr Asn Ile Met Val Thr Ile 
    50                  55                  60                  


Ser Thr Ala Thr Ile Thr Ile Leu Ile Ile Ile Phe Gly Glu Ile Leu 
65                  70                  75                  80  


Pro Lys Val Leu Met Arg Val Asn Ala Glu Lys Val Met Pro Tyr Leu 
                85                  90                  95      


Leu Tyr Phe Met Lys Phe Cys His Phe Ile Phe Lys Pro Ile Thr Phe 
            100                 105                 110         


Leu Met Asp Lys Val Thr Thr Phe Ile Met Asn Tyr Phe Val Pro Lys 
        115                 120                 125             


Arg Leu Arg Asp Ala Glu Lys Arg Ser Ala Leu Ser Ser Met Asp Asp 
    130                 135                 140                 


Ile Thr Thr Ile Ile His Leu Gly His Lys Glu Gly Ile Ile Lys Glu 
145                 150                 155                 160 


Tyr Thr His Glu Met Leu Thr Gly Val Ile Asp Phe Arg Asn Lys Thr 
                165                 170                 175     


Val Glu Glu Ile Met Thr Pro Arg Val Asp Met Val Cys Ile Glu Ala 
            180                 185                 190         


Glu Thr Asp Val Asn Glu Ile Ile Lys Leu Thr Val Glu Thr Gly Leu 
        195                 200                 205             


Ser Arg Phe Pro Val Tyr Glu Glu Thr Val Asp His Ile Ile Gly Ile 
    210                 215                 220                 


Phe His Thr Arg Ala Leu Phe Lys Glu Tyr Val Lys Gly Gly Gly Lys 
225                 230                 235                 240 


Met Asn Lys Ile Lys Lys Lys Ala Ile Asp Tyr Ile Met Leu Pro Tyr 
                245                 250                 255     


Phe Val Pro Glu Thr Lys Thr Ile Ser Ser Leu Phe Ser Asp Met Gln 
            260                 265                 270         


Lys Lys Lys Leu Gln Met Val Ile Thr Ile Asp Glu Tyr Gly Gly Thr 
        275                 280                 285             


Ala Gly Leu Val Thr Met Glu Asp Ile Ile Glu Glu Ile Met Gly Asp 
    290                 295                 300                 


Ile Glu Asp Glu Ser Asp Lys Lys Glu Ala Asp Val Ile Arg Phe Lys 
305                 310                 315                 320 


Gly Lys Arg Ile Ile Ile Asn Gly Asn Ala Ser Ile Glu Asp Val Asn 
                325                 330                 335     


Lys Thr Leu Lys Leu Glu Leu Glu His Glu Glu Tyr Gln Thr Ile Ala 
            340                 345                 350         


Gly Tyr Val Ile Asp Met Leu Asp His Ile Pro Glu Thr Asn Glu Arg 
        355                 360                 365             


Phe Ile Leu Lys Gly Tyr Arg Val Arg Ile Met Lys Val Glu Asp Arg 
    370                 375                 380                 


Arg Ile Val Glu Met Glu Phe Thr Pro Ile Lys Phe Ala Arg Thr Asn 
385                 390                 395                 400 


Glu Ser Asp Asn Ile Asp Ile Gln Glu Thr Ser Asp Ser Glu Lys Asn 
                405                 410                 415     


Asp Leu Glu Ile Leu Asn Glu 
            420             


<210>  11
<211>  224
<212>  PRT
<213>  Brachyspira

<400>  11

Met Glu Lys Ser Ala Phe Tyr Ile Asp Ile Gln Asn Lys Ser Asn Lys 
1               5                   10                  15      


Ser Lys Lys Ile Gly Glu Leu Tyr Ser Ala Ile Ser His Gly Ile Gly 
            20                  25                  30          


Ala Leu Leu Gly Ile Ala Gly Leu Val Leu Met Leu Val Lys Ile Lys 
        35                  40                  45              


Met Asn Pro Ile Pro Ile Ile Ile Tyr Gly Val Gly Ile Ile Phe Leu 
    50                  55                  60                  


Tyr Thr Phe Ser Ser Leu Tyr His Phe Phe Pro Asp Gly Lys Ile Lys 
65                  70                  75                  80  


Gln Ile Phe Arg Lys Phe Asp His Ile Gly Ile Tyr Val Phe Ile Ala 
                85                  90                  95      


Ala Thr Tyr Thr Pro Val Cys Ile Phe Ser Leu Pro Arg Asn Ile Gly 
            100                 105                 110         


Ile Pro Ile Leu Ser Val Ile Trp Ser Cys Ala Leu Ile Gly Ile Leu 
        115                 120                 125             


Ser Asn Thr Val Ile Lys Tyr Lys Asn Ile Val Leu Arg Leu Val Leu 
    130                 135                 140                 


Tyr Ile Leu Met Gly Trp Ile Ile Ile Phe Ala Phe Lys Pro Leu Met 
145                 150                 155                 160 


Asn Arg Phe Asp Ile Leu His Leu Asn Trp Leu Ile Trp Gly Gly Ile 
                165                 170                 175     


Phe Tyr Thr Ile Gly Ala Phe Leu Tyr Ala Leu Gly Lys Lys Cys Asn 
            180                 185                 190         


Asp Lys Thr Lys Gln Phe Thr His Asp Ile Phe His Ile Phe Val Leu 
        195                 200                 205             


Met Gly Ser Phe Cys His Tyr Trp Phe Leu Tyr Ser Tyr Val Ile Asn 
    210                 215                 220                 


<210>  12
<211>  223
<212>  PRT
<213>  Brachyspira

<400>  12

Met Asn Ala Asp Leu Asn Asn Asn Ile Val Lys Asn Ser Val Ser Lys 
1               5                   10                  15      


Ile Ser Ala Val Ile Cys Ile Ile Cys Ala Ser Ser Ala Ile Ala Val 
            20                  25                  30          


Leu Val Leu Leu Ile Ile Asn Ser Lys Thr Ala Arg Glu Ile Thr Ser 
        35                  40                  45              


Phe Ser Leu Tyr Ser Ser Phe Leu Thr Ile Phe Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ile Tyr His Phe Phe Pro Phe Asn Asn Lys Ala Lys Lys Val Phe Tyr 
65                  70                  75                  80  


Ile Leu Ser His Ala Phe Phe Ile Met Met Ile Trp Gly Ile Tyr Ile 
                85                  90                  95      


Pro Pro Cys Leu Ile Ser Leu Gln Asn Gly Trp Gly Trp Ser Phe Phe 
            100                 105                 110         


Gly Ile Ile Thr Gly Leu Cys Ala Leu Gly Ile Thr Leu Arg Ser Val 
        115                 120                 125             


Phe Gly Tyr Arg Trp Arg Gly Ala Thr Glu Thr Ile Tyr Tyr Phe Leu 
    130                 135                 140                 


Leu Asn Trp Val Trp Leu Ile Ala Ile Ser Lys Ile Ser Thr Ala Val 
145                 150                 155                 160 


Gly Glu Tyr Gly Ala Ile Leu Tyr Leu Thr Gly Phe Leu Leu Leu Asn 
                165                 170                 175     


Ile Ala Met Val Phe Tyr Arg Leu Ala Met Tyr Glu Ala Asn Arg Arg 
            180                 185                 190         


Tyr Thr Leu Phe Leu Pro Leu Phe Tyr Ser Leu Leu Ile Ile Ser Asn 
        195                 200                 205             


Ile Cys His Ala Val Phe Met Phe Arg Tyr Val Ala Asn Ile Phe 
    210                 215                 220             


<210>  13
<211>  240
<212>  PRT
<213>  Brachyspira

<400>  13

Met Arg Leu Asp Glu Tyr Val His Ser Glu Cys Tyr Thr Glu Ser Arg 
1               5                   10                  15      


Ser Lys Ala Gln Asp Ile Ile Leu Ala Gly Cys Val Phe Val Asn Gly 
            20                  25                  30          


Val Lys Val Thr Ser Lys Ala His Lys Ile Lys Asp Thr Asp Asn Ile 
        35                  40                  45              


Glu Val Val Gln Asn Ile Lys Tyr Val Ser Arg Ala Gly Glu Lys Leu 
    50                  55                  60                  


Glu Lys Ala Phe Val Glu Phe Gly Ile Ser Val Glu Asn Lys Ile Cys 
65                  70                  75                  80  


Leu Asp Ile Gly Ala Ser Thr Gly Gly Phe Thr Asp Cys Leu Leu Lys 
                85                  90                  95      


His Gly Ala Lys Lys Val Tyr Ala Leu Asp Val Gly His Asn Gln Leu 
            100                 105                 110         


Val Tyr Lys Leu Arg Asn Asp Asn Arg Val Val Ser Ile Glu Asp Phe 
        115                 120                 125             


Asn Ala Lys Asp Ile Asn Lys Glu Met Phe Asn Asp Glu Ile Pro Ser 
    130                 135                 140                 


Val Ile Val Ser Asp Val Ser Phe Ile Ser Ile Thr Lys Ile Ala Pro 
145                 150                 155                 160 


Ile Ile Phe Lys Glu Leu Asn Asn Leu Glu Phe Trp Val Thr Leu Ile 
                165                 170                 175     


Lys Pro Gln Phe Glu Ala Glu Arg Gly Asp Val Ser Lys Gly Gly Ile 
            180                 185                 190         


Ile Arg Asp Asp Ile Leu Arg Glu Lys Ile Leu Asn Asn Ala Ile Ser 
        195                 200                 205             


Lys Ile Ile Asp Cys Gly Phe Lys Glu Val Asn Arg Thr Ile Ser Pro 
    210                 215                 220                 


Ile Lys Gly Ala Lys Gly Asn Ile Glu Tyr Leu Ala His Phe Ile Ile 
225                 230                 235                 240 


<210>  14
<211>  828
<212>  PRT
<213>  Brachyspira

<400>  14

Met Phe Gln Phe His Leu Thr Ser Lys Ala Lys Lys Val Ile Glu Leu 
1               5                   10                  15      


Tyr Ala Gln Glu Glu Ala Lys Arg Leu Asn His Asp Met Val Thr Pro 
            20                  25                  30          


Glu His Ile Leu Leu Gly Leu Leu His Glu Ser Glu Ala Leu Ala Thr 
        35                  40                  45              


Arg Val Leu Met Arg Leu Lys Ile Asp Leu Asp Arg Leu Lys Leu Glu 
    50                  55                  60                  


Leu Glu Ser Ala Met Val Lys Ser Ser Thr Thr Lys Val Phe Gly Thr 
65                  70                  75                  80  


Leu Pro Thr Ala Pro Arg Val Gln Lys Leu Ile Ser Arg Ser Ala Glu 
                85                  90                  95      


Glu Ala Arg Ala Leu Ser His Asn Tyr Ile Gly Thr Glu His Leu Leu 
            100                 105                 110         


Leu Gly Leu Leu Arg Glu Glu Ser Gly Thr Ala Tyr Asn Val Leu Thr 
        115                 120                 125             


Ser Met Gly Leu Glu Leu Thr Ile Leu Arg Gln Glu Ile Leu Lys Met 
    130                 135                 140                 


Leu Gly Val Ala Gly Ser Asn Ile Ser Ser Met Glu Gln Thr Ser Gln 
145                 150                 155                 160 


Glu Asp Asn Val Lys Lys Val Lys Thr Pro Thr Leu Asp Gln Phe Ala 
                165                 170                 175     


Arg Asp Leu Thr Lys Met Ala Arg Asp Lys Ala Leu Asp Arg Val Ile 
            180                 185                 190         


Gly Arg Glu Asn Glu Val Met Arg Val Val Gln Ile Leu Ser Arg Arg 
        195                 200                 205             


Lys Lys Asn Asn Pro Ile Leu Leu Gly Glu Pro Gly Val Gly Lys Thr 
    210                 215                 220                 


Ala Ile Val Glu Gly Leu Ala Glu Lys Ile Val Ala Ala Asp Val Pro 
225                 230                 235                 240 


Asp Ile Leu Leu Lys Lys Arg Val Leu Thr Leu Asp Leu Ser Ser Val 
                245                 250                 255     


Val Ala Gly Thr Lys Tyr Arg Gly Glu Phe Glu Glu Arg Ile Lys Asn 
            260                 265                 270         


Ile Val Leu Glu Ile Lys Lys Ala Ser Asn Ile Ile Ile Phe Ile Asp 
        275                 280                 285             


Glu Leu His Thr Leu Ile Gly Ala Gly Gly Ala Glu Gly Ala Leu Asp 
    290                 295                 300                 


Ala Ala Asn Met Leu Lys Pro Ala Leu Ser Arg Gly Glu Ile Gln Cys 
305                 310                 315                 320 


Ile Gly Ala Thr Thr Ile Asn Glu Tyr Lys Lys Tyr Ile Glu Lys Asp 
                325                 330                 335     


Gly Ala Leu Val Arg Arg Phe Gln Pro Ile Asn Val Glu Glu Pro Ser 
            340                 345                 350         


Ile Glu Asp Thr Ile Glu Ile Leu Asn Gly Ile Lys Gly Lys Tyr Glu 
        355                 360                 365             


Glu His His Lys Val Lys Tyr Thr Asp Glu Ala Ile Asn Ala Ala Thr 
    370                 375                 380                 


Val Leu Ser Lys Arg Tyr Ile Phe Glu Arg His Leu Pro Asp Lys Ala 
385                 390                 395                 400 


Ile Asp Leu Ile Asp Glu Ala Gly Ser Arg Ala Arg Leu Leu Asn Met 
                405                 410                 415     


Thr Arg Pro Gln Glu Phe Lys Asp Leu Glu Lys Lys Ile Glu Glu Leu 
            420                 425                 430         


Asn Gln Gln Lys Lys Arg Val Val Glu Ser Gln Asn Phe Glu Asp Ala 
        435                 440                 445             


Ala Lys Ile Arg Asp Glu Ile Thr Ser Leu Gln Glu Glu Leu Ser Lys 
    450                 455                 460                 


Lys Glu Glu Lys Trp Arg Glu Glu Arg Glu Lys Ile Glu Thr Phe Ile 
465                 470                 475                 480 


Glu Glu Asp Asp Ile Arg His Val Ile Ser Glu Ile Thr Asn Ile Pro 
                485                 490                 495     


Ile Lys Arg Leu Leu Asn Ser Glu Ser Lys Arg Leu Ile Gly Met Glu 
            500                 505                 510         


Glu Glu Leu His Gln Lys Val Val Gly Gln Lys Glu Ala Ile Ser Ser 
        515                 520                 525             


Ile Ser Lys Ala Ile Arg Arg Ser Arg Ala Gly Leu Lys Thr Ser Lys 
    530                 535                 540                 


Arg Pro Leu Gly Ser Phe Ile Phe Leu Gly Pro Thr Gly Val Gly Lys 
545                 550                 555                 560 


Thr Ala Leu Ala Lys Val Leu Ser Glu Phe Met Phe Gly Asp Ser Asp 
                565                 570                 575     


Ala Leu Ile Arg Ile Asp Met Ser Glu Phe Met Glu Lys Phe Ala Val 
            580                 585                 590         


Ser Arg Leu Ile Gly Ala Pro Pro Gly Tyr Val Gly Tyr Glu Glu Gly 
        595                 600                 605             


Gly Gly Leu Thr Glu Lys Val Arg Arg Lys Pro Tyr Ser Leu Ile Leu 
    610                 615                 620                 


Phe Asp Glu Ile Glu Lys Ala His Pro Asp Val Thr Asn Ile Leu Leu 
625                 630                 635                 640 


Gln Val Leu Glu Glu Gly Gln Leu Thr Asp Asn Phe Gly Arg Lys Val 
                645                 650                 655     


Asp Phe Ser Asn Thr Ile Ile Ile Ile Thr Ser Asn Leu Gly Ala Arg 
            660                 665                 670         


Asp Ile Val Lys Gly Ser Ser Leu Gly Phe Asn Ala Val Gly Ser Glu 
        675                 680                 685             


Lys Asp Ala Asn Asp Ile Lys Asn Phe Ala Leu Glu Glu Leu Lys Gln 
    690                 695                 700                 


Asn Phe Asn Pro Glu Phe Leu Asn Arg Ile Asp Asp Ile Ile Val Phe 
705                 710                 715                 720 


His Thr Leu Ser Lys Glu Asp Leu Lys Asp Ile Ile Asn Ile Met Leu 
                725                 730                 735     


Lys Glu Leu Asn Glu Ala Ile Lys Glu Arg Asn Ile Val Ile Asn Leu 
            740                 745                 750         


Ser Glu Glu Ala Lys Asn Tyr Ile Ile Asp Lys Gly Phe Asp Lys Lys 
        755                 760                 765             


Tyr Gly Ala Arg Ser Leu Arg Arg Ala Ile Gln Lys Glu Ile Glu Asp 
    770                 775                 780                 


Tyr Val Ser Thr Glu Ile Leu Phe Gly Asn Ile Glu Asp Gly Asp Thr 
785                 790                 795                 800 


Ile Asn Val Asp Ala Asn Asp Gly Ser Leu Ile Phe Ser Tyr Asp Lys 
                805                 810                 815     


Ser Val Lys Thr Glu Asn Lys Glu Leu Ser Lys Ser 
            820                 825             


<210>  15
<211>  268
<212>  PRT
<213>  Brachyspira

<400>  15

Met Pro Ile Lys Lys Leu Ile Ser Lys Ile Val Lys Lys Lys Asp Ser 
1               5                   10                  15      


Asp Thr Glu Lys Asn Asn Tyr Ile Asn Leu Ser Ala Leu Thr Glu Ala 
            20                  25                  30          


Glu Arg Glu Ile Ile Thr Asn Thr Ile Glu Leu Lys Ser Lys Ser Val 
        35                  40                  45              


Arg Glu Ile Met Val Pro Arg Val Asp Val Val Met Ile Pro Met Glu 
    50                  55                  60                  


Ser Ser Tyr Asp Lys Val Ile Lys Ala Phe Asn Arg Asp Arg Asn Ser 
65                  70                  75                  80  


Arg Ile Pro Val Tyr Lys Asp Gly Ile Asp Asp Ile Val Gly Val Leu 
                85                  90                  95      


Tyr Val Lys Asp Leu Ile Asp Ala Glu Glu Lys Asn Phe Ser Leu Lys 
            100                 105                 110         


Lys Ile Leu His Lys Pro Leu Phe Val Pro Ile Ser Ile Ser Leu Met 
        115                 120                 125             


Glu Leu Leu Lys Asn Phe Arg Glu Lys Gln Ile His Ile Ala Met Val 
    130                 135                 140                 


Val Asp Glu Tyr Gly Gly Phe Ser Gly Ile Val Ser Met Glu Asp Val 
145                 150                 155                 160 


Leu Glu Gln Ile Ile Gly Asp Ile Arg Asp Glu Tyr Asp Glu Glu Asp 
                165                 170                 175     


Glu Glu Ile Lys Ser Asn Asp Asp Gly Thr Tyr Leu Val Asp Ala Arg 
            180                 185                 190         


Thr Arg Ile Asp Asp Phe Asn Lys Tyr Glu Ile Leu Pro Pro Ile Pro 
        195                 200                 205             


Asp Asp Glu Ala Asp Thr Val Gly Gly Phe Leu Phe Ser Tyr Leu Gly 
    210                 215                 220                 


Arg Leu Pro Lys Arg Asn Glu Asp Ile Glu Tyr Asn Gly Tyr Ser Phe 
225                 230                 235                 240 


Thr Val Val Gly Lys Ser Gly Asn Ile Val Thr Lys Ile Arg Ile Glu 
                245                 250                 255     


Lys Leu Lys Lys Asp Asn Thr Ala Lys Asn Lys Asp 
            260                 265             


<210>  16
<211>  78
<212>  PRT
<213>  Brachyspira

<400>  16

Met Ala Leu Ile Asp Glu Ile Lys Asp Val Val Ala Asn Gln Leu Asn 
1               5                   10                  15      


Ile Ser Asp Lys Ser Lys Ile Thr Asp Thr Ala Ser Phe Val Asp Asp 
            20                  25                  30          


Leu Asn Ala Asp Ser Leu Asp Leu Val Glu Leu Ile Met Glu Leu Glu 
        35                  40                  45              


Lys Arg Tyr Glu Ile Lys Ile Pro Gln Glu Asp Gln Glu Lys Ile Lys 
    50                  55                  60                  


Asn Val Ala Asp Ala Ala Lys Tyr Ile Glu Glu His Lys Lys 
65                  70                  75              


<210>  17
<211>  335
<212>  PRT
<213>  Brachyspira

<400>  17

Tyr Ala Ser Pro Glu Ser Leu Arg Gly Glu Gly Ile Asp Val Tyr Met 
1               5                   10                  15      


Gly His Asp Val Thr Lys Ile Asp Trp Ala Asn Lys Lys Leu Cys Val 
            20                  25                  30          


Lys Glu Leu Lys Thr Gly Lys Glu Phe Glu Asp Thr Tyr Asp Lys Leu 
        35                  40                  45              


Ile Leu Ala Thr Gly Ser Trp Pro Val Thr Pro Pro Ile Glu Gly Leu 
    50                  55                  60                  


Lys Gln Glu Gly Thr Thr Tyr Gly Leu Lys Lys Gly Ile Phe Phe Ser 
65                  70                  75                  80  


Lys Leu Tyr Gln Gln Gly Gln Glu Ile Ile Asp Glu Ile Ala Lys Pro 
                85                  90                  95      


Asp Val Lys Lys Val Met Val Val Gly Ala Gly Tyr Ile Gly Val Glu 
            100                 105                 110         


Leu Ile Glu Ala Phe Lys Asn His Gly Lys Glu Val Ile Leu Met Glu 
        115                 120                 125             


Ala Met Pro Arg Val Met Ala Asn Tyr Phe Asp Lys Glu Ile Thr Asp 
    130                 135                 140                 


Glu Ala Glu Lys Arg Ile Lys Glu Ala Gly Ile Glu Met His Leu Gly 
145                 150                 155                 160 


Glu Thr Val Lys Lys Phe Glu Gly Asp Asp Arg Val Lys Lys Val Val 
                165                 170                 175     


Thr Asp Lys Gly Ser Tyr Asp Val Asp Met Val Val Met Ser Val Gly 
            180                 185                 190         


Phe Arg Pro Asn Asn Glu Leu Tyr Lys Asp Tyr Leu Glu Thr Leu Pro 
        195                 200                 205             


Asn Gly Ala Ile Val Val Asp Thr Thr Met Lys Thr Thr Lys Asp Pro 
    210                 215                 220                 


Asp Val Phe Ala Ile Gly Asp Cys Ala Thr Val Tyr Ser Arg Ala Ser 
225                 230                 235                 240 


Glu Lys Gln Glu Tyr Ile Ala Leu Ala Thr Asn Ala Val Arg Met Gly 
                245                 250                 255     


Ile Val Ala Ala Asn Asn Ala Leu Gly Lys His Val Glu Tyr Cys Gly 
            260                 265                 270         


Thr Gln Gly Ser Asn Ala Ile Cys Val Phe Gly Tyr Asn Met Ala Ser 
        275                 280                 285             


Thr Gly Trp Ser Glu Glu Thr Ala Lys Lys Lys Gly Leu Lys Val Lys 
    290                 295                 300                 


Ser Asn Phe Phe Lys Asp Ser Glu Arg Pro Glu Phe Met Pro Thr Asn 
305                 310                 315                 320 


Glu Asp Val Leu Val Lys Ile Ile Tyr Glu Glu Gly Ser Arg Arg 
                325                 330                 335 


<210>  18
<211>  25
<212>  DNA
<213>  Brachyspira

<400>  18
gtttgatyct ggctcagarc kaacg                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Brachyspira

<400>  19
cttccggtac ggmtgccttg ttacg                                             25


<210>  20
<211>  21
<212>  DNA
<213>  Brachyspira

<400>  20
tagcytgcgg tatygcwctt t                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  Brachyspira

<400>  21
gcmtgwatag cttcrgcatg rt                                                22


<210>  22
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  22
ggtattggag atgaatatac                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  23
tgatgtagaa ggcttctata                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  24
ggagtggaga gaaagtatta                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  25
tgctgtaagc agacttatag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  26
agctgtcctt cttcaagtac                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  27
agtcgtagga cagaaagaag                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  28
ccctcttcat aaccaacata                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  29
agggacttgc tgaaaagata                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  30
ttgtaccagc aacaactgaa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  31
agctctatct acagcaatac                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  32
ttacgaatgc ctgctatttg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  33
ctatttttag gcgaggcttt                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  34
ggaaaaaggg atcctggaac                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  35
tcctgcttgt tatcagcaca                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  36
ctattggaga gcgtacatct                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  37
taccctgtac ctacagaaca                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  38
ctcctcccgt tcaatatgta                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  39
aatccgccat gtaaaactgc                                                   20


<210>  40
<211>  18
<212>  DNA
<213>  Brachyspira

<400>  40
tggtgaaata ctgccaaa                                                     18


<210>  41
<211>  20
<212>  DNA
<213>  Brachyspira

<400>  41
tgttgttata tcgtccatac                                                   20


<210>  42
<211>  21
<212>  DNA
<213>  Brachyspira

<400>  42
gttaatgctg aaaaaatgat g                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Brachyspira

<400>  43
aagctcttgt atggaatata c                                                 21


<210>  44
<211>  19
<212>  DNA
<213>  Brachyspira

<400>  44
caagttctat gatacctac                                                    19


<210>  45
<211>  21
<212>  DNA
<213>  Brachyspira

<400>  45
gccgccttta acataytctt t                                                 21


