﻿               SEQUENCE LISTING

<110> INSERM
      LFB

<120> Fragment du facteur H pour son utilisation comme agent anti-angiogénique

<130> BCT160432 QT

<160> 19

<170> BiSSAP 1.3

<210> 1
<211> 1231
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         
Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             
Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 
Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 
Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     
Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         
Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             
Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 
Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 
Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     
Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
        995                 1000                1005            
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
    1010                1015                1020                
Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
1025                1030                1035                1040
Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
                1045                1050                1055    
Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
            1060                1065                1070        
Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
        1075                1080                1085            
Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp 
    1090                1095                1100                
Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
1105                1110                1115                1120
Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
                1125                1130                1135    
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
            1140                1145                1150        
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
        1155                1160                1165            
Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
    1170                1175                1180                
Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
1185                1190                1195                1200
Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
                1205                1210                1215    
Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            1220                1225                1230    

<210> 2
<211> 54
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR7

<400> 2
Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly Arg 
1               5                   10                  15      
Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly Tyr 
            20                  25                  30          
Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly Trp 
        35                  40                  45              
Ser Pro Thr Pro Arg Cys 
    50                  

<210> 3
<211> 162
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR7 -DNA

<400> 3
tgttatttcc cttacctgga gaacggctac aaccagaatt acgggcgcaa atttgtgcag     60

ggcaagagca tcgacgtggc ttgccatccc ggctatgctc tgcctaaggc acagaccaca    120

gtgacctgta tggagaatgg gtggtcccct acaccaaggt gc                       162


<210> 4
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR1-7

<400> 4
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Ser His His His His His His 
    450                 455             

<210> 5
<211> 1440
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR1-7 DNA

<400> 5
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac      60

tgtaacgaac tgcccccacg aaggaatacc gaaatcctga cagggagttg gtcagaccag     120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga     180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc     240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc     300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg     360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt     420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc     480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc     540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag     600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca     660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc     720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct     780

tcctgcgagg aaaaatcttg tgacaacccc tacatcccta atggggatta ttccccactg     840

cgcatcaagc accgaactgg agacgagatt acctaccagt gcaggaatgg cttctacccc     900

gctacacgcg gcaacactgc aaagtgtact tctaccggat ggattcccgc tccccggtgc     960

acactgaaac cttgtgacta cccagatatt aagcacggag gcctgtacca tgagaatatg    1020

cggagaccat atttccccgt ggcagtcggc aagtactatt cctactattg cgatgaacac    1080

tttgagaccc ccagcggctc ctattgggac cacatccatt gcacacagga tgggtggtct    1140

cctgccgtgc catgcctgcg aaaatgttat ttcccttacc tggagaacgg ctacaaccag    1200

aattacgggc gcaaatttgt gcagggcaag agcatcgacg tggcttgcca tcccggctat    1260

gctctgccta aggcacagac cacagtgacc tgtatggaga atgggtggtc ccctacacca    1320

aggtgcatcc gcgtgaaaac tggcgctagc ggcagccacc accatcacca ccattgataa    1380

ggatccagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg    1440


<210> 6
<211> 1102
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 1-18

<400> 6
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         
Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             
Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 
Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 
Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     
Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         
Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             
Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 
Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 
Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     
Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
        995                 1000                1005            
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
    1010                1015                1020                
Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
1025                1030                1035                1040
Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
                1045                1050                1055    
Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
            1060                1065                1070        
Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
        1075                1080                1085            
Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys 
    1090                1095                1100        

<210> 7
<211> 3306
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR1-18 DNA

<400> 7
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac       60

tgtaacgaac tgcccccacg aaggaatacc gaaatcctga cagggagttg gtcagaccag      120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga      180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc      240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc      300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg      360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt      420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc      480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc      540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag      600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca      660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc      720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct      780

tcctgcgagg aaaaatcttg tgacaacccc tacatcccta atggggatta ttccccactg      840

cgcatcaagc accgaactgg agacgagatt acctaccagt gcaggaatgg cttctacccc      900

gctacacgcg gcaacactgc aaagtgtact tctaccggat ggattcccgc tccccggtgc      960

acactgaaac cttgtgacta cccagatatt aagcacggag gcctgtacca tgagaatatg     1020

cggagaccat atttccccgt ggcagtcggc aagtactatt cctactattg cgatgaacac     1080

tttgagaccc ccagcggctc ctattgggac cacatccatt gcacacagga tgggtggtct     1140

cctgccgtgc catgcctgcg aaaatgttat ttcccttacc tggagaacgg ctacaaccag     1200

aattacgggc gcaaatttgt gcagggcaag agcatcgacg tggcttgcca tcccggctat     1260

gctctgccta aggcacagac cacagtgacc tgtatggaga atgggtggtc ccctacacca     1320

aggtgcatcc gcgtgaaaac ttgttctaag agcagcatcg acattgaaaa cgggttcatt     1380

tctgagagtc agtatacata cgccctgaaa gagaaggcta aataccagtg caagctggga     1440

tatgtgacag ccgacggcga aacttcaggg agcatcacct gcgggaaaga tggatggtcc     1500

gcccagccta cctgcatcaa gtcttgtgac attccagtgt ttatgaacgc tagaacaaag     1560

aacgatttca cttggttcaa gctgaatgac actctggatt acgaatgcca cgacggctat     1620

gagtccaata ccggatctac taccggcagt atcgtgtgcg gctacaacgg gtggagcgac     1680

ctgcccatct gctatgagcg ggaatgtgag ctgccaaaaa ttgatgtgca cctggtcccc     1740

gacagaaaga aagatcagta caaagtgggc gaggtcctga aattcagctg caagcccggg     1800

tttaccatcg tgggacctaa cagcgtccag tgttatcatt tcgggctgtc ccccgatctg     1860

cctatttgca aggagcaggt gcagagctgt ggaccacctc cagaactgct gaacggaaat     1920

gtgaaggaga aaacaaagga ggaatacggc cacagcgaag tggtcgagta ctattgcaat     1980

ccacggtttc tgatgaaagg ccccaacaag atccagtgcg tggacgggga gtggacaact     2040

ctgcccgtgt gcatcgtcga ggaatccacc tgtggcgata ttccagaact ggagcatggg     2100

tgggcacagc tgtcaagccc cccttactat tacggcgaca gcgtggaatt caactgctcc     2160

gagtctttta caatgatcgg acacagatcc atcacttgta ttcatggcgt gtggacccag     2220

ctgccacagt gcgtcgccat tgacaaactg aagaaatgca agtcctctaa tctgatcatt     2280

ctggaggaac acctgaagaa caagaaggaa ttcgatcata actctaatat caggtaccgc     2340

tgccgaggaa aggagggctg gattcacacc gtgtgcatta atgggaggtg ggaccccgaa     2400

gtcaactgct ctatggcaca gatccagctg tgcccaccac ctccacagat tcctaacagt     2460

cataatatga ccacaactct gaattacagg gacggcgaga aggtgtctgt cctgtgccag     2520

gaaaactatc tgatccagga gggagaggaa attacctgta aagatggccg ctggcagtca     2580

atccctctgt gcgtggaaaa gattccatgt agccagcccc ctcagatcga gcacggaaca     2640

attaatagtt cacggagctc ccaggagagt tacgctcatg gcaccaagct gtcatataca     2700

tgcgaagggg gattcagaat cagcgaggaa aacgagacca catgttacat gggcaaatgg     2760

tctagtccac cccagtgcga agggctgcct tgtaagagtc ctccagagat ttcacacgga     2820

gtggtcgcac atatgagtga ctcatatcag tacggcgagg aagtgacata caaatgcttc     2880

gagggctttg ggatcgacgg ccctgccatt gctaaatgtc tgggagaaaa gtggtcacac     2940

ccccctagct gcatcaagac tgactgtctg tcactgccca gctttgaaaa tgctattcct     3000

atgggggaga agaaagacgt gtacaaagca ggagagcagg tcacatatac ttgcgccaca     3060

tattacaaga tggacggcgc ttcaaacgtg acttgtatca atagccggtg gaccgggaga     3120

cctacatgca gggatactag ctgcgtgaac ccacccaccg tccagaatgc ctacatcgtg     3180

agccggcaga tgtctaagta tccaagtggc gaacgggtga gataccagtg ccgcagcccc     3240

tatgagatgt tcggcgacga ggaagtgatg tgcctgaacg ggaattggac cgagcctcca     3300

cagtgc                                                                3306


<210> 8
<211> 874
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 7-20

<400> 8
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Ala Ser Gly Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn 
            20                  25                  30          
Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala 
        35                  40                  45              
Cys His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys 
    50                  55                  60                  
Met Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr 
65                  70                  75                  80  
Cys Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser 
                85                  90                  95      
Gln Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu 
            100                 105                 110         
Gly Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly 
        115                 120                 125             
Lys Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile 
    130                 135                 140                 
Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys 
145                 150                 155                 160 
Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn 
                165                 170                 175     
Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser 
            180                 185                 190         
Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp 
        195                 200                 205             
Val His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu 
    210                 215                 220                 
Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn 
225                 230                 235                 240 
Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys 
                245                 250                 255     
Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly 
            260                 265                 270         
Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val 
        275                 280                 285             
Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile 
    290                 295                 300                 
Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu 
305                 310                 315                 320 
Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln 
                325                 330                 335     
Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys 
            340                 345                 350         
Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His 
        355                 360                 365             
Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys 
    370                 375                 380                 
Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn 
385                 390                 395                 400 
Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly 
                405                 410                 415     
Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro 
            420                 425                 430         
Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro 
        435                 440                 445             
Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp 
    450                 455                 460                 
Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu 
465                 470                 475                 480 
Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu 
                485                 490                 495     
Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly 
            500                 505                 510         
Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr 
        515                 520                 525             
Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn 
    530                 535                 540                 
Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu 
545                 550                 555                 560 
Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala 
                565                 570                 575     
His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys 
            580                 585                 590         
Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly 
        595                 600                 605             
Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser 
    610                 615                 620                 
Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val 
625                 630                 635                 640 
Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys 
                645                 650                 655     
Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly 
            660                 665                 670         
Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln 
        675                 680                 685             
Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu 
    690                 695                 700                 
Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu 
705                 710                 715                 720 
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys 
                725                 730                 735     
Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
            740                 745                 750         
Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
        755                 760                 765             
Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
    770                 775                 780                 
Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
785                 790                 795                 800 
Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
                805                 810                 815     
Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
            820                 825                 830         
Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
        835                 840                 845             
Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
    850                 855                 860                 
Gly Gly Ser Gly His His His His His His 
865                 870                 

<210> 9
<211> 2622
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 7-20 DNA

<400> 9
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgctagc      60

ggctgttatt tcccttacct ggagaacggc tacaaccaga attacgggcg caaatttgtg     120

cagggcaaga gcatcgacgt ggcttgccat cccggctatg ctctgcctaa ggcacagacc     180

acagtgacct gtatggagaa tgggtggtcc cctacaccaa ggtgcatccg cgtgaaaact     240

tgttctaaga gcagcatcga cattgaaaac gggttcattt ctgagagtca gtatacatac     300

gccctgaaag agaaggctaa ataccagtgc aagctgggat atgtgacagc cgacggcgaa     360

acttcaggga gcatcacctg cgggaaagat ggatggtccg cccagcctac ctgcatcaag     420

tcttgtgaca ttccagtgtt tatgaacgct agaacaaaga acgatttcac ttggttcaag     480

ctgaatgaca ctctggatta cgaatgccac gacggctatg agtccaatac cggatctact     540

accggcagta tcgtgtgcgg ctacaacggg tggagcgacc tgcccatctg ctatgagcgg     600

gaatgtgagc tgccaaaaat tgatgtgcac ctggtccccg acagaaagaa agatcagtac     660

aaagtgggcg aggtcctgaa attcagctgc aagcccgggt ttaccatcgt gggacctaac     720

agcgtccagt gttatcattt cgggctgtcc cccgatctgc ctatttgcaa ggagcaggtg     780

cagagctgtg gaccacctcc agaactgctg aacggaaatg tgaaggagaa aacaaaggag     840

gaatacggcc acagcgaagt ggtcgagtac tattgcaatc cacggtttct gatgaaaggc     900

cccaacaaga tccagtgcgt ggacggggag tggacaactc tgcccgtgtg catcgtcgag     960

gaatccacct gtggcgatat tccagaactg gagcatgggt gggcacagct gtcaagcccc    1020

ccttactatt acggcgacag cgtggaattc aactgctccg agtcttttac aatgatcgga    1080

cacagatcca tcacttgtat tcatggcgtg tggacccagc tgccacagtg cgtcgccatt    1140

gacaaactga agaaatgcaa gtcctctaat ctgatcattc tggaggaaca cctgaagaac    1200

aagaaggaat tcgatcataa ctctaatatc aggtaccgct gccgaggaaa ggagggctgg    1260

attcacaccg tgtgcattaa tgggaggtgg gaccccgaag tcaactgctc tatggcacag    1320

atccagctgt gcccaccacc tccacagatt cctaacagtc ataatatgac cacaactctg    1380

aattacaggg acggcgagaa ggtgtctgtc ctgtgccagg aaaactatct gatccaggag    1440

ggagaggaaa ttacctgtaa agatggccgc tggcagtcaa tccctctgtg cgtggaaaag    1500

attccatgta gccagccccc tcagatcgag cacggaacaa ttaatagttc acggagctcc    1560

caggagagtt acgctcatgg caccaagctg tcatatacat gcgaaggggg attcagaatc    1620

agcgaggaaa acgagaccac atgttacatg ggcaaatggt ctagtccacc ccagtgcgaa    1680

gggctgcctt gtaagagtcc tccagagatt tcacacggag tggtcgcaca tatgagtgac    1740

tcatatcagt acggcgagga agtgacatac aaatgcttcg agggctttgg gatcgacggc    1800

cctgccattg ctaaatgtct gggagaaaag tggtcacacc cccctagctg catcaagact    1860

gactgtctgt cactgcccag ctttgaaaat gctattccta tgggggagaa gaaagacgtg    1920

tacaaagcag gagagcaggt cacatatact tgcgccacat attacaagat ggacggcgct    1980

tcaaacgtga cttgtatcaa tagccggtgg accgggagac ctacatgcag ggatactagc    2040

tgcgtgaacc cacccaccgt ccagaatgcc tacatcgtga gccggcagat gtctaagtat    2100

ccaagtggcg aacgggtgag ataccagtgc cgcagcccct atgagatgtt cggcgacgag    2160

gaagtgatgt gcctgaacgg gaattggacc gagcctccac agtgcaaaga tagcaccggg    2220

aagtgtggac cccctccacc catcgacaac ggcgatatta cttcatttcc actgagcgtg    2280

tacgcacccg cctcaagcgt cgaataccag tgccagaacc tgtatcagct ggagggaaac    2340

aagcgcatca cctgtcgaaa cggccagtgg agtgagcctc caaagtgcct gcacccatgc    2400

gtgatctcac gggaaattat ggagaactac aatattgcac tgagatggac tgccaaacag    2460

aagctgtata gcaggaccgg agaatccgtg gagttcgtct gcaagcgagg ctaccggctg    2520

tcctctagaa gccataccct gagaactact tgttgggacg ggaaactgga ataccctact    2580

tgtgctaaga gaggcggaag cggccaccac catcaccacc at                       2622


<210> 10
<211> 744
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 7-18

<400> 10
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
            20                  25                  30          
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
        35                  40                  45              
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
    50                  55                  60                  
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
65                  70                  75                  80  
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
                85                  90                  95      
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
            100                 105                 110         
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
        115                 120                 125             
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
    130                 135                 140                 
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
145                 150                 155                 160 
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
                165                 170                 175     
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
            180                 185                 190         
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
        195                 200                 205             
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
    210                 215                 220                 
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
225                 230                 235                 240 
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
                245                 250                 255     
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
            260                 265                 270         
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
        275                 280                 285             
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
    290                 295                 300                 
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
305                 310                 315                 320 
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
                325                 330                 335     
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
            340                 345                 350         
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
        355                 360                 365             
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
    370                 375                 380                 
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
385                 390                 395                 400 
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
                405                 410                 415     
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
            420                 425                 430         
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
        435                 440                 445             
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
    450                 455                 460                 
Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
465                 470                 475                 480 
Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
                485                 490                 495     
Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
            500                 505                 510         
Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
        515                 520                 525             
Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
    530                 535                 540                 
Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
545                 550                 555                 560 
Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
                565                 570                 575     
Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
            580                 585                 590         
Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
        595                 600                 605             
Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
    610                 615                 620                 
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
625                 630                 635                 640 
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
                645                 650                 655     
Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
            660                 665                 670         
Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
        675                 680                 685             
Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
    690                 695                 700                 
Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
705                 710                 715                 720 
Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Gly Gly 
                725                 730                 735     
Ser Gly His His His His His His 
            740                 

<210> 11
<211> 2232
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 7-18 DNA

<400> 11
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac      60

tgttatttcc cttacctgga gaacggctac aaccagaatt acgggcgcaa atttgtgcag     120

ggcaagagca tcgacgtggc ttgccatccc ggctatgctc tgcctaaggc acagaccaca     180

gtgacctgta tggagaatgg gtggtcccct acaccaaggt gcatccgcgt gaaaacttgt     240

tctaagagca gcatcgacat tgaaaacggg ttcatttctg agagtcagta tacatacgcc     300

ctgaaagaga aggctaaata ccagtgcaag ctgggatatg tgacagccga cggcgaaact     360

tcagggagca tcacctgcgg gaaagatgga tggtccgccc agcctacctg catcaagtct     420

tgtgacattc cagtgtttat gaacgctaga acaaagaacg atttcacttg gttcaagctg     480

aatgacactc tggattacga atgccacgac ggctatgagt ccaataccgg atctactacc     540

ggcagtatcg tgtgcggcta caacgggtgg agcgacctgc ccatctgcta tgagcgggaa     600

tgtgagctgc caaaaattga tgtgcacctg gtccccgaca gaaagaaaga tcagtacaaa     660

gtgggcgagg tcctgaaatt cagctgcaag cccgggttta ccatcgtggg acctaacagc     720

gtccagtgtt atcatttcgg gctgtccccc gatctgccta tttgcaagga gcaggtgcag     780

agctgtggac cacctccaga actgctgaac ggaaatgtga aggagaaaac aaaggaggaa     840

tacggccaca gcgaagtggt cgagtactat tgcaatccac ggtttctgat gaaaggcccc     900

aacaagatcc agtgcgtgga cggggagtgg acaactctgc ccgtgtgcat cgtcgaggaa     960

tccacctgtg gcgatattcc agaactggag catgggtggg cacagctgtc aagcccccct    1020

tactattacg gcgacagcgt ggaattcaac tgctccgagt cttttacaat gatcggacac    1080

agatccatca cttgtattca tggcgtgtgg acccagctgc cacagtgcgt cgccattgac    1140

aaactgaaga aatgcaagtc ctctaatctg atcattctgg aggaacacct gaagaacaag    1200

aaggaattcg atcataactc taatatcagg taccgctgcc gaggaaagga gggctggatt    1260

cacaccgtgt gcattaatgg gaggtgggac cccgaagtca actgctctat ggcacagatc    1320

cagctgtgcc caccacctcc acagattcct aacagtcata atatgaccac aactctgaat    1380

tacagggacg gcgagaaggt gtctgtcctg tgccaggaaa actatctgat ccaggaggga    1440

gaggaaatta cctgtaaaga tggccgctgg cagtcaatcc ctctgtgcgt ggaaaagatt    1500

ccatgtagcc agccccctca gatcgagcac ggaacaatta atagttcacg gagctcccag    1560

gagagttacg ctcatggcac caagctgtca tatacatgcg aagggggatt cagaatcagc    1620

gaggaaaacg agaccacatg ttacatgggc aaatggtcta gtccacccca gtgcgaaggg    1680

ctgccttgta agagtcctcc agagatttca cacggagtgg tcgcacatat gagtgactca    1740

tatcagtacg gcgaggaagt gacatacaaa tgcttcgagg gctttgggat cgacggccct    1800

gccattgcta aatgtctggg agaaaagtgg tcacaccccc ctagctgcat caagactgac    1860

tgtctgtcac tgcccagctt tgaaaatgct attcctatgg gggagaagaa agacgtgtac    1920

aaagcaggag agcaggtcac atatacttgc gccacatatt acaagatgga cggcgcttca    1980

aacgtgactt gtatcaatag ccggtggacc gggagaccta catgcaggga tactagctgc    2040

gtgaacccac ccaccgtcca gaatgcctac atcgtgagcc ggcagatgtc taagtatcca    2100

agtggcgaac gggtgagata ccagtgccgc agcccctatg agatgttcgg cgacgaggaa    2160

gtgatgtgcc tgaacgggaa ttggaccgag cctccacagt gcggcggaag cggccaccac    2220

catcaccacc at                                                        2232


<210> 12
<211> 211
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 6-8

<400> 12
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
            20                  25                  30          
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
        35                  40                  45              
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
    50                  55                  60                  
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
65                  70                  75                  80  
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
                85                  90                  95      
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
            100                 105                 110         
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
        115                 120                 125             
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
    130                 135                 140                 
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
145                 150                 155                 160 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
                165                 170                 175     
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
            180                 185                 190         
Asp Gly Trp Ser Ala Gln Pro Thr Cys Gly Gly Ser Gly His His His 
        195                 200                 205             
His His His 
    210     

<210> 13
<211> 633
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 6-8 DNA

<400> 13
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac      60

tgtgactacc cagatattaa gcacggaggc ctgtaccatg agaatatgcg gagaccatat     120

ttccccgtgg cagtcggcaa gtactattcc tactattgcg atgaacactt tgagaccccc     180

agcggctcct attgggacca catccattgc acacaggatg ggtggtctcc tgccgtgcca     240

tgcctgcgaa aatgttattt cccttacctg gagaacggct acaaccagaa ttacgggcgc     300

aaatttgtgc agggcaagag catcgacgtg gcttgccatc ccggctatgc tctgcctaag     360

gcacagacca cagtgacctg tatggagaat gggtggtccc ctacaccaag gtgcatccgc     420

gtgaaaactt gttctaagag cagcatcgac attgaaaacg ggttcatttc tgagagtcag     480

tatacatacg ccctgaaaga gaaggctaaa taccagtgca agctgggata tgtgacagcc     540

gacggcgaaa cttcagggag catcacctgc gggaaagatg gatggtccgc ccagcctacc     600

tgcggcggaa gcggccacca ccatcaccac cat                                  633


<210> 14
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 1-4

<400> 14
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Ser His 
            260                 265                 270         
His His His His His 
        275         

<210> 15
<211> 831
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 1-4 DNA

<400> 15
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac      60

tgtaacgaac tgcccccacg aaggaatacc gaaatcctga cagggagttg gtcagaccag     120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga     180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc     240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc     300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg     360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt     420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc     480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc     540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag     600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca     660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc     720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct     780

tcctgcgagg aaaaatctgg cgctagcggc agccaccacc atcaccacca t              831


<210> 16
<211> 399
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 1-6

<400> 16
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Gly Ala Ser Gly Ser His His His His His His 
385                 390                 395                 

<210> 17
<211> 1197
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 1-6 DNA

<400> 17
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaggac      60

tgtaacgaac tgcccccacg aaggaatacc gaaatcctga cagggagttg gtcagaccag     120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga     180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc     240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc     300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg     360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt     420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc     480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc     540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag     600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca     660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc     720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct     780

tcctgcgagg aaaaatcttg tgacaacccc tacatcccta atggggatta ttccccactg     840

cgcatcaagc accgaactgg agacgagatt acctaccagt gcaggaatgg cttctacccc     900

gctacacgcg gcaacactgc aaagtgtact tctaccggat ggattcccgc tccccggtgc     960

acactgaaac cttgtgacta cccagatatt aagcacggag gcctgtacca tgagaatatg    1020

cggagaccat atttccccgt ggcagtcggc aagtactatt cctactattg cgatgaacac    1080

tttgagaccc ccagcggctc ctattgggac cacatccatt gcacacagga tgggtggtct    1140

cctgccgtgc catgcctgcg aaaaggcgct agcggcagcc accaccatca ccaccat       1197


<210> 18
<211> 815
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCR 8-20

<400> 18
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Ala Ser Gly Cys Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly 
            20                  25                  30          
Phe Ile Ser Glu Ser Gln Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys 
        35                  40                  45              
Tyr Gln Cys Lys Leu Gly Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly 
    50                  55                  60                  
Ser Ile Thr Cys Gly Lys Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile 
65                  70                  75                  80  
Lys Ser Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp 
                85                  90                  95      
Phe Thr Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp 
            100                 105                 110         
Gly Tyr Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly 
        115                 120                 125             
Tyr Asn Gly Trp Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu 
    130                 135                 140                 
Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln 
145                 150                 155                 160 
Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr 
                165                 170                 175     
Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro 
            180                 185                 190         
Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro 
        195                 200                 205             
Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly 
    210                 215                 220                 
His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys 
225                 230                 235                 240 
Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro 
                245                 250                 255     
Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu 
            260                 265                 270         
His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser 
        275                 280                 285             
Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser 
    290                 295                 300                 
Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala 
305                 310                 315                 320 
Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu 
                325                 330                 335     
Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg 
            340                 345                 350         
Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn 
        355                 360                 365             
Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu 
    370                 375                 380                 
Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr 
385                 390                 395                 400 
Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn 
                405                 410                 415     
Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp 
            420                 425                 430         
Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro 
        435                 440                 445             
Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser 
    450                 455                 460                 
Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg 
465                 470                 475                 480 
Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser 
                485                 490                 495     
Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser 
            500                 505                 510         
His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu 
        515                 520                 525             
Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile 
    530                 535                 540                 
Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys 
545                 550                 555                 560 
Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly 
                565                 570                 575     
Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys 
            580                 585                 590         
Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn 
        595                 600                 605             
Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn 
    610                 615                 620                 
Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys 
625                 630                 635                 640 
Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
                645                 650                 655     
Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 
            660                 665                 670         
Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
        675                 680                 685             
Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
    690                 695                 700                 
Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
705                 710                 715                 720 
Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
                725                 730                 735     
Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
            740                 745                 750         
Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
        755                 760                 765             
Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
    770                 775                 780                 
Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
785                 790                 795                 800 
Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
                805                 810                 815 

<210> 19
<211> 2445
<212> DNA
<213> Artificial Sequence

<220> 
<223> SCR 8-20 DNA

<400> 19
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgctagc      60

ggctgttcta agagcagcat cgacattgaa aacgggttca tttctgagag tcagtataca     120

tacgccctga aagagaaggc taaataccag tgcaagctgg gatatgtgac agccgacggc     180

gaaacttcag ggagcatcac ctgcgggaaa gatggatggt ccgcccagcc tacctgcatc     240

aagtcttgtg acattccagt gtttatgaac gctagaacaa agaacgattt cacttggttc     300

aagctgaatg acactctgga ttacgaatgc cacgacggct atgagtccaa taccggatct     360

actaccggca gtatcgtgtg cggctacaac gggtggagcg acctgcccat ctgctatgag     420

cgggaatgtg agctgccaaa aattgatgtg cacctggtcc ccgacagaaa gaaagatcag     480

tacaaagtgg gcgaggtcct gaaattcagc tgcaagcccg ggtttaccat cgtgggacct     540

aacagcgtcc agtgttatca tttcgggctg tcccccgatc tgcctatttg caaggagcag     600

gtgcagagct gtggaccacc tccagaactg ctgaacggaa atgtgaagga gaaaacaaag     660

gaggaatacg gccacagcga agtggtcgag tactattgca atccacggtt tctgatgaaa     720

ggccccaaca agatccagtg cgtggacggg gagtggacaa ctctgcccgt gtgcatcgtc     780

gaggaatcca cctgtggcga tattccagaa ctggagcatg ggtgggcaca gctgtcaagc     840

cccccttact attacggcga cagcgtggaa ttcaactgct ccgagtcttt tacaatgatc     900

ggacacagat ccatcacttg tattcatggc gtgtggaccc agctgccaca gtgcgtcgcc     960

attgacaaac tgaagaaatg caagtcctct aatctgatca ttctggagga acacctgaag    1020

aacaagaagg aattcgatca taactctaat atcaggtacc gctgccgagg aaaggagggc    1080

tggattcaca ccgtgtgcat taatgggagg tgggaccccg aagtcaactg ctctatggca    1140

cagatccagc tgtgcccacc acctccacag attcctaaca gtcataatat gaccacaact    1200

ctgaattaca gggacggcga gaaggtgtct gtcctgtgcc aggaaaacta tctgatccag    1260

gagggagagg aaattacctg taaagatggc cgctggcagt caatccctct gtgcgtggaa    1320

aagattccat gtagccagcc ccctcagatc gagcacggaa caattaatag ttcacggagc    1380

tcccaggaga gttacgctca tggcaccaag ctgtcatata catgcgaagg gggattcaga    1440

atcagcgagg aaaacgagac cacatgttac atgggcaaat ggtctagtcc accccagtgc    1500

gaagggctgc cttgtaagag tcctccagag atttcacacg gagtggtcgc acatatgagt    1560

gactcatatc agtacggcga ggaagtgaca tacaaatgct tcgagggctt tgggatcgac    1620

ggccctgcca ttgctaaatg tctgggagaa aagtggtcac acccccctag ctgcatcaag    1680

actgactgtc tgtcactgcc cagctttgaa aatgctattc ctatggggga gaagaaagac    1740

gtgtacaaag caggagagca ggtcacatat acttgcgcca catattacaa gatggacggc    1800

gcttcaaacg tgacttgtat caatagccgg tggaccggga gacctacatg cagggatact    1860

agctgcgtga acccacccac cgtccagaat gcctacatcg tgagccggca gatgtctaag    1920

tatccaagtg gcgaacgggt gagataccag tgccgcagcc cctatgagat gttcggcgac    1980

gaggaagtga tgtgcctgaa cgggaattgg accgagcctc cacagtgcaa agatagcacc    2040

gggaagtgtg gaccccctcc acccatcgac aacggcgata ttacttcatt tccactgagc    2100

gtgtacgcac ccgcctcaag cgtcgaatac cagtgccaga acctgtatca gctggaggga    2160

aacaagcgca tcacctgtcg aaacggccag tggagtgagc ctccaaagtg cctgcaccca    2220

tgcgtgatct cacgggaaat tatggagaac tacaatattg cactgagatg gactgccaaa    2280

cagaagctgt atagcaggac cggagaatcc gtggagttcg tctgcaagcg aggctaccgg    2340

ctgtcctcta gaagccatac cctgagaact acttgttggg acgggaaact ggaataccct    2400

acttgtgcta agagaggcgg aagcggccac caccatcacc accat                    2445


