                         SEQUENCE LISTING

<110>  Intervet International BV
 
<120>  BVDV marker vaccine

<130>  24249

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  681
<212>  DNA
<213>  Bovine viral diarrhea virus


<220>
<221>  CDS
<222>  (1)..(681)
<223>  BVDV Erns

<400>  1
gag aac ata acg caa tgg aac tta caa gat aat gga acg gaa ggc ata         48
Glu Asn Ile Thr Gln Trp Asn Leu Gln Asp Asn Gly Thr Glu Gly Ile           
1               5                   10                  15                

caa cga gcc atg ttt caa aga gga gtg aat aga agt tta cat ggg atc         96
Gln Arg Ala Met Phe Gln Arg Gly Val Asn Arg Ser Leu His Gly Ile           
            20                  25                  30                    

tgg cca gag aaa atc tgt aca ggt gtt cct tcc cac ctg gcc act gac        144
Trp Pro Glu Lys Ile Cys Thr Gly Val Pro Ser His Leu Ala Thr Asp           
        35                  40                  45                        

aca gaa ttg aag gca att cat ggt atg atg gat gca agt gag aag aca        192
Thr Glu Leu Lys Ala Ile His Gly Met Met Asp Ala Ser Glu Lys Thr           
    50                  55                  60                            

aat tat acg tgc tgc aga ctc caa cgc cat gaa tgg aac aaa cat ggt        240
Asn Tyr Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His Gly           
65                  70                  75                  80            

tgg tgc aac tgg tac aac att gaa cct tgg atc ctc ctt atg aat aaa        288
Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Leu Leu Met Asn Lys           
                85                  90                  95                

act cag gcc aac ctt act gag ggt cag cca cta agg gag tgt gcc gtc        336
Thr Gln Ala Asn Leu Thr Glu Gly Gln Pro Leu Arg Glu Cys Ala Val           
            100                 105                 110                   

aca tgc cgg tat gat cga gat agt gac ctg aat gta gta aca caa gcc        384
Thr Cys Arg Tyr Asp Arg Asp Ser Asp Leu Asn Val Val Thr Gln Ala           
        115                 120                 125                       

agg gat agc ccc aca cca tta aca ggt tgc aag aaa ggc aaa aac ttt        432
Arg Asp Ser Pro Thr Pro Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe           
    130                 135                 140                           

tcc ttt gca ggc ata ttg gta caa ggg cct tgc aac ttt gaa ata gcc        480
Ser Phe Ala Gly Ile Leu Val Gln Gly Pro Cys Asn Phe Glu Ile Ala           
145                 150                 155                 160           

gta agt gat gtg ctg ttc aaa gag cat gat tgc act agt gtg att caa        528
Val Ser Asp Val Leu Phe Lys Glu His Asp Cys Thr Ser Val Ile Gln           
                165                 170                 175               

gac aca gct cac tac ctc gta gac ggg atg acc aac tcc cta gag agt        576
Asp Thr Ala His Tyr Leu Val Asp Gly Met Thr Asn Ser Leu Glu Ser           
            180                 185                 190                   

gcc agg caa ggg acc gcg aaa cta aca act tgg ctg ggc agg cag ctt        624
Ala Arg Gln Gly Thr Ala Lys Leu Thr Thr Trp Leu Gly Arg Gln Leu           
        195                 200                 205                       

ggg ata cta gga aag aaa ctg gaa aac aag agt aag aca tgg ttt ggg        672
Gly Ile Leu Gly Lys Lys Leu Glu Asn Lys Ser Lys Thr Trp Phe Gly           
    210                 215                 220                           

gca tat gca                                                            681
Ala Tyr Ala                                                               
225                                                                       


<210>  2
<211>  227
<212>  PRT
<213>  Bovine viral diarrhea virus

<400>  2

Glu Asn Ile Thr Gln Trp Asn Leu Gln Asp Asn Gly Thr Glu Gly Ile 
1               5                   10                  15      


Gln Arg Ala Met Phe Gln Arg Gly Val Asn Arg Ser Leu His Gly Ile 
            20                  25                  30          


Trp Pro Glu Lys Ile Cys Thr Gly Val Pro Ser His Leu Ala Thr Asp 
        35                  40                  45              


Thr Glu Leu Lys Ala Ile His Gly Met Met Asp Ala Ser Glu Lys Thr 
    50                  55                  60                  


Asn Tyr Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His Gly 
65                  70                  75                  80  


Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Leu Leu Met Asn Lys 
                85                  90                  95      


Thr Gln Ala Asn Leu Thr Glu Gly Gln Pro Leu Arg Glu Cys Ala Val 
            100                 105                 110         


Thr Cys Arg Tyr Asp Arg Asp Ser Asp Leu Asn Val Val Thr Gln Ala 
        115                 120                 125             


Arg Asp Ser Pro Thr Pro Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe 
    130                 135                 140                 


Ser Phe Ala Gly Ile Leu Val Gln Gly Pro Cys Asn Phe Glu Ile Ala 
145                 150                 155                 160 


Val Ser Asp Val Leu Phe Lys Glu His Asp Cys Thr Ser Val Ile Gln 
                165                 170                 175     


Asp Thr Ala His Tyr Leu Val Asp Gly Met Thr Asn Ser Leu Glu Ser 
            180                 185                 190         


Ala Arg Gln Gly Thr Ala Lys Leu Thr Thr Trp Leu Gly Arg Gln Leu 
        195                 200                 205             


Gly Ile Leu Gly Lys Lys Leu Glu Asn Lys Ser Lys Thr Trp Phe Gly 
    210                 215                 220                 


Ala Tyr Ala 
225         


<210>  3
<211>  666
<212>  DNA
<213>  Bungowannah virus


<220>
<221>  CDS
<222>  (1)..(666)

<400>  3
acc aac gtg aca caa tgg aac tta tgg gac aat aaa agt act aca gac         48
Thr Asn Val Thr Gln Trp Asn Leu Trp Asp Asn Lys Ser Thr Thr Asp           
1               5                   10                  15                

ata cat agc gtc atg ttt tct aga ggg att aaa agg agt ctg cat gga         96
Ile His Ser Val Met Phe Ser Arg Gly Ile Lys Arg Ser Leu His Gly           
            20                  25                  30                    

att tgg ccc aca caa atc tgc aaa ggg atc cct aca cat cta gca gca        144
Ile Trp Pro Thr Gln Ile Cys Lys Gly Ile Pro Thr His Leu Ala Ala           
        35                  40                  45                        

gac tat gaa ctg aaa agg att cac ggg atg gtg gat gca agc ccc atg        192
Asp Tyr Glu Leu Lys Arg Ile His Gly Met Val Asp Ala Ser Pro Met           
    50                  55                  60                            

acc aac ttc aca tgt tgt agg cta cag aga cat gag tgg aac aag cat        240
Thr Asn Phe Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His           
65                  70                  75                  80            

ggg tgg tgc aac tgg tac aat ata gag ccg tgg atc aat ctc atg aat        288
Gly Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Asn Leu Met Asn           
                85                  90                  95                

aat acc caa gga cta tta aac act gga gac aat ttc act gag tgc gca        336
Asn Thr Gln Gly Leu Leu Asn Thr Gly Asp Asn Phe Thr Glu Cys Ala           
            100                 105                 110                   

gtc aca tgc agg tat gat gca gac tta ggg gtg aat ata gtg act caa        384
Val Thr Cys Arg Tyr Asp Ala Asp Leu Gly Val Asn Ile Val Thr Gln           
        115                 120                 125                       

gcc agg act act cca act atc ctg act ggc tgt aag aaa ggg cac aac        432
Ala Arg Thr Thr Pro Thr Ile Leu Thr Gly Cys Lys Lys Gly His Asn           
    130                 135                 140                           

ttc tct ttc tca ggg gag gtc agg gcc tca ccc tgc aac ttt gag tta        480
Phe Ser Phe Ser Gly Glu Val Arg Ala Ser Pro Cys Asn Phe Glu Leu           
145                 150                 155                 160           

act gct gaa gac ttg ctc agg atc atg gat cac acc aac tgc gag gga        528
Thr Ala Glu Asp Leu Leu Arg Ile Met Asp His Thr Asn Cys Glu Gly           
                165                 170                 175               

ttt acc tac ttc ggg gaa gga atc gtt gac ggt tac acc gag gta gta        576
Phe Thr Tyr Phe Gly Glu Gly Ile Val Asp Gly Tyr Thr Glu Val Val           
            180                 185                 190                   

gag aag gcc agg tca agt ggt ttc agg gct ctc aca tgg ttg tcg agt        624
Glu Lys Ala Arg Ser Ser Gly Phe Arg Ala Leu Thr Trp Leu Ser Ser           
        195                 200                 205                       

aag att gaa aac acc aag aaa aaa ata ttc gga gct gaa gcc                666
Lys Ile Glu Asn Thr Lys Lys Lys Ile Phe Gly Ala Glu Ala                   
    210                 215                 220                           


<210>  4
<211>  222
<212>  PRT
<213>  Bungowannah virus

<400>  4

Thr Asn Val Thr Gln Trp Asn Leu Trp Asp Asn Lys Ser Thr Thr Asp 
1               5                   10                  15      


Ile His Ser Val Met Phe Ser Arg Gly Ile Lys Arg Ser Leu His Gly 
            20                  25                  30          


Ile Trp Pro Thr Gln Ile Cys Lys Gly Ile Pro Thr His Leu Ala Ala 
        35                  40                  45              


Asp Tyr Glu Leu Lys Arg Ile His Gly Met Val Asp Ala Ser Pro Met 
    50                  55                  60                  


Thr Asn Phe Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His 
65                  70                  75                  80  


Gly Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Asn Leu Met Asn 
                85                  90                  95      


Asn Thr Gln Gly Leu Leu Asn Thr Gly Asp Asn Phe Thr Glu Cys Ala 
            100                 105                 110         


Val Thr Cys Arg Tyr Asp Ala Asp Leu Gly Val Asn Ile Val Thr Gln 
        115                 120                 125             


Ala Arg Thr Thr Pro Thr Ile Leu Thr Gly Cys Lys Lys Gly His Asn 
    130                 135                 140                 


Phe Ser Phe Ser Gly Glu Val Arg Ala Ser Pro Cys Asn Phe Glu Leu 
145                 150                 155                 160 


Thr Ala Glu Asp Leu Leu Arg Ile Met Asp His Thr Asn Cys Glu Gly 
                165                 170                 175     


Phe Thr Tyr Phe Gly Glu Gly Ile Val Asp Gly Tyr Thr Glu Val Val 
            180                 185                 190         


Glu Lys Ala Arg Ser Ser Gly Phe Arg Ala Leu Thr Trp Leu Ser Ser 
        195                 200                 205             


Lys Ile Glu Asn Thr Lys Lys Lys Ile Phe Gly Ala Glu Ala 
    210                 215                 220         


<210>  5
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heterologous Pestivrus Erns gene: Bungowannah + BVDV1 CP7


<220>
<221>  CDS
<222>  (1)..(687)

<400>  5
acc aac gtg aca caa tgg aac tta tgg gac aat aaa agt act aca gac         48
Thr Asn Val Thr Gln Trp Asn Leu Trp Asp Asn Lys Ser Thr Thr Asp           
1               5                   10                  15                

ata cat agc gtc atg ttt tct aga ggg att aaa agg agt ctg cat gga         96
Ile His Ser Val Met Phe Ser Arg Gly Ile Lys Arg Ser Leu His Gly           
            20                  25                  30                    

att tgg ccc aca caa atc tgc aaa ggg atc cct aca cat cta gca gca        144
Ile Trp Pro Thr Gln Ile Cys Lys Gly Ile Pro Thr His Leu Ala Ala           
        35                  40                  45                        

gac tat gaa ctg aaa agg att cac ggg atg gtg gat gca agc ccc atg        192
Asp Tyr Glu Leu Lys Arg Ile His Gly Met Val Asp Ala Ser Pro Met           
    50                  55                  60                            

acc aac ttc aca tgt tgt agg cta cag aga cat gag tgg aac aag cat        240
Thr Asn Phe Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His           
65                  70                  75                  80            

ggg tgg tgc aac tgg tac aat ata gag ccg tgg atc aat ctc atg aat        288
Gly Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Asn Leu Met Asn           
                85                  90                  95                

aat acc caa gga cta tta aac act gga gac aat ttc act gag tgc gca        336
Asn Thr Gln Gly Leu Leu Asn Thr Gly Asp Asn Phe Thr Glu Cys Ala           
            100                 105                 110                   

gtc aca tgc agg tat gat gca gac tta ggg gtg aat ata gtg act caa        384
Val Thr Cys Arg Tyr Asp Ala Asp Leu Gly Val Asn Ile Val Thr Gln           
        115                 120                 125                       

gcc agg act act cca act atc ctg act ggc tgt aag aaa ggg cac aac        432
Ala Arg Thr Thr Pro Thr Ile Leu Thr Gly Cys Lys Lys Gly His Asn           
    130                 135                 140                           

ttc tct ttc tca ggg gag gtc agg gcc tca ccc tgc aac ttt gag tta        480
Phe Ser Phe Ser Gly Glu Val Arg Ala Ser Pro Cys Asn Phe Glu Leu           
145                 150                 155                 160           

act gct gaa gac ttg ctc agg atc atg gat cac acc aac tgc gag gga        528
Thr Ala Glu Asp Leu Leu Arg Ile Met Asp His Thr Asn Cys Glu Gly           
                165                 170                 175               

ttt acc tac ttc ggg gaa gga atc gtt gac ggt tac acc gag gta gta        576
Phe Thr Tyr Phe Gly Glu Gly Ile Val Asp Gly Tyr Thr Glu Val Val           
            180                 185                 190                   

gag agt gcc agg caa ggg acc gcg aaa cta aca act tgg ctg ggc agg        624
Glu Ser Ala Arg Gln Gly Thr Ala Lys Leu Thr Thr Trp Leu Gly Arg           
        195                 200                 205                       

cag ctt ggg ata cta gga aag aaa ctg gaa aac aag agt aag aca tgg        672
Gln Leu Gly Ile Leu Gly Lys Lys Leu Glu Asn Lys Ser Lys Thr Trp           
    210                 215                 220                           

ttt ggg gca tat gca                                                    687
Phe Gly Ala Tyr Ala                                                       
225                                                                       


<210>  6
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Thr Asn Val Thr Gln Trp Asn Leu Trp Asp Asn Lys Ser Thr Thr Asp 
1               5                   10                  15      


Ile His Ser Val Met Phe Ser Arg Gly Ile Lys Arg Ser Leu His Gly 
            20                  25                  30          


Ile Trp Pro Thr Gln Ile Cys Lys Gly Ile Pro Thr His Leu Ala Ala 
        35                  40                  45              


Asp Tyr Glu Leu Lys Arg Ile His Gly Met Val Asp Ala Ser Pro Met 
    50                  55                  60                  


Thr Asn Phe Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His 
65                  70                  75                  80  


Gly Trp Cys Asn Trp Tyr Asn Ile Glu Pro Trp Ile Asn Leu Met Asn 
                85                  90                  95      


Asn Thr Gln Gly Leu Leu Asn Thr Gly Asp Asn Phe Thr Glu Cys Ala 
            100                 105                 110         


Val Thr Cys Arg Tyr Asp Ala Asp Leu Gly Val Asn Ile Val Thr Gln 
        115                 120                 125             


Ala Arg Thr Thr Pro Thr Ile Leu Thr Gly Cys Lys Lys Gly His Asn 
    130                 135                 140                 


Phe Ser Phe Ser Gly Glu Val Arg Ala Ser Pro Cys Asn Phe Glu Leu 
145                 150                 155                 160 


Thr Ala Glu Asp Leu Leu Arg Ile Met Asp His Thr Asn Cys Glu Gly 
                165                 170                 175     


Phe Thr Tyr Phe Gly Glu Gly Ile Val Asp Gly Tyr Thr Glu Val Val 
            180                 185                 190         


Glu Ser Ala Arg Gln Gly Thr Ala Lys Leu Thr Thr Trp Leu Gly Arg 
        195                 200                 205             


Gln Leu Gly Ile Leu Gly Lys Lys Leu Glu Asn Lys Ser Lys Thr Trp 
    210                 215                 220                 


Phe Gly Ala Tyr Ala 
225                 


<210>  7
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  7
ctttcaagtc acaatgggaa ccaacgtgac acaatggaac                             40


<210>  8
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  8
cgcggtccct tgcctggcac tctctactac ctcggtgtaa ccgtcaac                    48


<210>  9
<211>  13743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA of mutant Pestivirus: pBVDV-1_dNpro_Erns-Bungo/CP7

<400>  9
gctagctaat acgactcact atagtatacg agaattagaa aaggcactcg tatacatatt       60

ggacactcta aaaaaaaaaa ataattaggc ctaggggaca aaaatcctcc ttagcgaagg      120

ccgaaaagag gctaaccatg cccttagtag gactagcaaa ataagggggg tagcaacagt      180

ggcgagttcg ttggatggct gaagccctga gtacagggta gtcgtcagtg gttcgacgct      240

ttggaggaca agcctcgaga tgccacgtgg acgagggcat gcccacagca catcttaacc      300

tggacagggg tcgttcaggt gaaaacggtt taaccaaccg ctacgaatac agtctgatag      360

gatgctgcag aggcccactg tattgctact gaaaatctct gctgtacatg gcacatggag      420

ttgatcacaa atgaactttt atacaaaaca ttaattaact ccgacacaaa agatgaaggg      480

gtggtgagga agaagcaaca aaagccagat aggttggaaa aggggagaat gaagataaca      540

cctaaggagt cagagaaaga cagtaagacc aagccgccag atgctacgat agtggtagat      600

ggagtcaagt atcaggtaaa gaaaaaagga aaagtcaaga gcaagaacac ccaggacggc      660

ttataccaca acaaaaataa acctcaagag tcgcgcaaga aactagagaa agccctattg      720

gcctgggcaa taatagccct ggttttcttt caagtcacaa tgggaaccaa cgtgacacaa      780

tggaacttat gggacaataa aagtactaca gacatacata gcgtcatgtt ttcgaggggg      840

attaaaagga gtctgcatgg aatttggccc acacaaatct gcaaagggat ccctacacat      900

ctagcagcag actatgaact gaaaaggatt cacgggatgg tggatgcaag ccccatgacc      960

aacttcacat gttgtaggct acagagacat gagtggaaca agcatgggtg gtgcaactgg     1020

tacaatatag agccgtggat caatctcatg aataataccc aaggactatt aaacactgga     1080

gacaatttca ctgagtgcgc agtcacatgc aggtatgatg cagacttagg ggtgaatata     1140

gtgactcaag ccaggactac tccaactatc ctgactggct gtaagaaagg gcacaacttc     1200

tctttctcag gggaggtcag ggcctcaccc tgcaactttg agttaactgc tgaagacttg     1260

ctcaggatca tggatcacac caactgcgag ggatttacct acttcgggga aggaatcgtt     1320

gacggttaca ccgaggtagt agagagtgcc aggcaaggga ccgcgaaact aacaacttgg     1380

ctgggcaggc agcttgggat actaggaaag aaactggaaa acaagagtaa gacatggttt     1440

ggggcatatg cagcctctcc ctattgtgag gtagaacgga agcttggtta catctggtat     1500

acaaagaatt gcactccagc ctgtttgcct aggaatacaa agatcatcgg ccccggtagg     1560

tttgacacca atgccgagga tggtaaaata ctgcatgaga tggggggtca cttgtcggag     1620

gtgctactac tctcagtggt agtgctgtcc gatttcgctc cagagacagc cagtgtgata     1680

tacttgattc ttcatttctc catcccacaa ggacacactg atatacaaga ttgtgacaaa     1740

aaccaactaa acctcaccgt agaactcaca acagcagaag taataccagg ctcagtttgg     1800

aacttgggta aatatgtttg tgtaagacca gattggtggc cttatgagac agccacagtc     1860

ctggtgattg aagaggtggg tcaagtaatt aaggttgtct taagggcgtt aaaagatctg     1920

acgcgcattt ggaccgctgc tacaaccact gcattcttgg tttgtctggt gaaggtagtg     1980

agaggccaag tgttacaagg tatactgtgg ctgatgctca taacaggggc gcaaggatat     2040

ccagactgca aacccggctt ttcatacgcc atagccaaaa atgatgagat tggcccactt     2100

ggagctacag gcctcaccac tcagtggtac gaatactcgg atgggatgcg gctgcaggac     2160

tcagtagttg aagtttggtg taaaaatgga gagatcaaat atctaatcag atgcgggagg     2220

gaagccaggt atctggctgt tctacacacg agagccttgc cgacatctgt agtatttgaa     2280

aaaatttttg atgggaaaga acaagaggac atagtagaaa tggatgacaa ctttgaattc     2340

ggtctttgcc cgtgtgatgc tagacccttg ataaggggaa aatttaatac aacacttcta     2400

aatgggccag ccttccagat ggtttgccct ataggatgga cagggactgt aagctgtaca     2460

ctggccaata aggatacgtt agccacaatc gttgtgagaa cgtataagag ggtcaggcct     2520

tttccatata ggcaggactg tgtcacccag aaaaccatcg gggaagacct ctacgactgt     2580

gccttaggag ggaattggac ttgtgtgccg ggggatgcac tacgatatgt agctgggccc     2640

gttgagtctt gtgagtggtg tggttacaag tttttaaaaa gtgagggtct gccgcatttc     2700

ccaatcggca aatgcaggct gaagaatgag agtggctata gacaagtgga tgagacttct     2760

tgcaacagaa acggcgtggc tatagtgcca tctggcacgg tcaaatgcaa gataggggac     2820

acggtggtgc aagtcattgc aatggatgat aaactagggc ctatgccttg caaaccacat     2880

gaaatcatat ccagtgaggg gccagtggaa aagacggcat gcaccttcaa ctacacaaga     2940

acattaaaaa acaagtactt tgagcccagg gataactatt ttcaacaata catgttaaag     3000

ggggagtacc aatattggtt tgacctagag atcactgacc accaccgaga ttacttcgct     3060

gagtccctgt tggtgatagt agttgcactc ctgggtggca ggtacgtgct ttggctgctg     3120

gtcacataca tgatcttatc agaacagatg gcctcgggtg tccagtatgg ggcaggtgaa     3180

atagtgatga tgggcaactt gttaacacat gacagtgttg aagtggtgac atatttctta     3240

ctactatacc tactactaag agaggaaaac accaaaaaat gggtcatact tatataccac     3300

atcatagtaa tgcatcctct aaaatcggtg acggtgatat tgctaatggt tggggggatg     3360

gcaaaggctg aaccaggtgc ccaggggtac ctagagcagg tagaccttag ttttacgatg     3420

attacgatca tcgtaatagg tctggttata gctaggcgtg atcccactgt ggtgccacta     3480

gtcactatag tcgcggcact gaagatcaca ggactaggct ttgggcccgg agtggatgca     3540

gctatggcag ttctcacctt aaccctactg atgactagtt atgtgacaga ctacttcagg     3600

tataaaaggt ggatacaatg tatcctcagc ttagtagccg gggtgttcct tatccggacc     3660

ctcaaacatc taggtgaact caaaacccct gagctgacca taccaaattg gaggccacta     3720

accttcatac tattatacct gacttcagca acagttgtta caagatggaa aattgatata     3780

gctggcatat tcctgcaagg ggcccctatc cttttgatga tcgccaccct atgggctgac     3840

ttcttgactc ttgttctgat cctacccacc tacgaattag ccaagctgta ctacctaaag     3900

aacgtcaaga ctgacgtgga gaagagttgg ggtgttcctt atccggaccc tcaaacgctg     3960

ggggggttag actacaggac aattgactct gtctatgatg tggatgaaag tggagaaggc     4020

gtgtacctct tcccgtccag acagaagaaa aataagaata tcagcatact cttgcccctc     4080

atcagagcta cgctaataag ttgtattagc agcaaatggc agatggtgta tatggcttac     4140

ttaaccctgg actttatgta ctacatgcac agaaaggtta ttgaagagat atcagggagt     4200

accaatgtga tgtctagagt gatagcagca cttatagaat taaactggtc catggaagaa     4260

gaagagagca agggcttaaa gaagtttttt atactatctg gaaggttgag gaaccttata     4320

ataaagcata aggttaggaa ccagactgtg gcaagctggt atggggagga agaagtctac     4380

ggcatgccaa aagtcgtaac cataataagg gcctgcacgc taaacaagaa caaacattgc     4440

ataatatgca cagtatgtga ggctagaaag tggaagggag gcaactgccc taaatgcggc     4500

cgccacggga agcccatcat ttgtgggatg actctagcgg attttgaaga aaggcactac     4560

aagagaattt ttataaggga aggtaacttt gaaggaccct tcaggcagga atacaatggg     4620

tttgtacaat acaccgctag ggggcaattg ttcctgagaa atttacccat attggcaacc     4680

aaagtaaaaa tgatcatggt aggcaaccta ggagaggaaa tcggtgatct agaacaccta     4740

ggatggatcc taaggggacc tgccgtgtgc aagaaaataa ctgagcacga aaaatgccat     4800

gtcaacatac tggacaagct gactgcgttt tttggagtta tgccaagagg gactacacca     4860

agggctccgg tgagattccc aacagcacta ctaaaggtaa ggaggggatt ggaaaccggt     4920

tgggcttaca cgcatcaagg tggcataagc tcagtagacc atgtgaccgc tggcaaggat     4980

ctattggttt gtgacagtat gggtagaact agagtggttt gccaaagcaa caacaagtta     5040

actgatgaga cagaatatgg tgtcaagacg gactccggat gtccagatgg tgccagatgc     5100

tatgtattaa acccagaggc agtaaatata tcagggtcca agggagctgt cgtacacctc     5160

caaaaaacgg gtggggaatt tacatgtgtt actgcatcag gtacaccggc cttcttcgac     5220

ctgaaaaatt tgaaaggatg gtcgggtcta cccatatttg aagcctccag cggcagagtg     5280

gttggcagag tcaaagtggg aaagaatgag gaatccaaac ccacaaaatt aatgagtggt     5340

atccaaactg tttctaaaaa tacggccgat ttaacagaaa tggtcaagaa gataaccagc     5400

atgaacaggg gggactttag gcagataacc cttgcaacag gggcagggaa gaccactgag     5460

ctcccaaaag cagtgataga ggagatagga cgacacaaac gggtactagt gctcatacca     5520

ttaagagcag cagctgagtc agtctatcaa tacatgagat tgaaacaccc aagtatctcc     5580

tttaacctga gaatagggga catgaaagaa ggggatatgg caaccgggat cacctacgcc     5640

tcatatggat atttttgcca aatgccacaa ccaaagctca gagcagcaat gatagagtat     5700

tcatacatat ttctggatga gtatcactgc gctactcctg agcagttggc tgttatagga     5760

aaaattcaca gattttctga gagcataaga gtggttgcca tgactgccac cccagcaggg     5820

tcagtaacca caacagggca aaaacaccca atagaagaat tcatagcccc tgaggtgatg     5880

aaaggggagg accttggaag ccagttcctt gacatagcgg ggttaaagat ccctgtagag     5940

gagatgaagg gtaacatgtt ggttttcgtg cccacgagga acatggcagt tgaagtagcc     6000

aagaaactaa aagccaaggg ctacaactca gggtattact acagtgggga agacccagct     6060

aacttgagag tggtaacatc acagtcccca tacgtcgtgg tagccactaa tgccatcgag     6120

tcaggggtaa cgctgccaga tttagataca gttgttgaca caggtctgaa atgtgagaag     6180

agggtgaggg tgtcttccaa aatacccttt atagtaacag gccttaagag aatggctgtc     6240

actgtgggcg aacaggctca gcggagaggc agggtaggta gagtgaaacc cggtaggtat     6300

tatagaagtc aggaaacagc aaccgggtca aaggactacc actatgactt gttacaggca     6360

cagaggtacg ggatcgaaga tgggatcaac gtaacaaagt cctttaggga gatgaattat     6420

gactggagcc tgtatgagga agacagcttg ctgataaccc agctggagat actgaacaat     6480

ctactcatct ctgaagattt accagcagct gttaaaaaca tcatggcaag aactgatcac     6540

ccagagccta tccagcttgc atataacagt tatgaggtcc aagtccctgt gctgttccca     6600

aaaataagga atggggaggt cacagacact tacgagaact actcattcct aaatgcaagg     6660

aaactagggg aagacgtgcc cgtgtacgtt tatgccaccg aagatgaaga tctggctgtg     6720

gaccttctag gcttggactg gccagaccca gggaatcagc aagtagtgga gactgggaag     6780

gcactgaagc aagtggtagg actgtcctct gccgaaaatg ccttgctcat agccctattt     6840

gggtatgtag gataccaagc cttgtcaaaa agacacgtcc caatgatcac agacatatac     6900

actatagaag atcaaagact agaggacaca acccaccttc aatatgcgcc caatgccata     6960

agaactgagg ggaaggagac tgaactaaag gaattagcag tgggtgactt ggacaaaatc     7020

atgggttcca tctcggacta tgcatcagag ggattgaatt tcgtaaggtc ccaagcagaa     7080

aagatgagat ctgcccccgc tttcaaagaa aacgtggaag ctgctaaagg gtacgtccaa     7140

aagtttattg attctctcat agaaaataaa gaaaccataa tcagatatgg cctgtgggga     7200

acacacacgg cactctacaa gagtattgcc gcgagattgg gtcatgaaac tgcattcgct     7260

acactagtga taaagtggct ggccttcggg ggtgagtcgg tgtcagacca catgagacaa     7320

gcagctgtcg acctggttgt ttattatgtg atcaataagc cctccttccc aggggattct     7380

gaaacccaac aggaaggaag gcgattcgtc gccagcctgt tcatctccgc tttggcaacc     7440

tacacataca aaacttggaa ttacaacaac ctctccaagg tagtagaacc agccttagca     7500

tacctcccct atgctaccaa tgcactaaaa atgtttaccc cgaccagact ggagagcgta     7560

gttatactta gtaccacaat atacaaaact tacctctcaa taaggaaggg aaagagtgat     7620

ggactgttgg gtacagggat cagtgcagca atggagattc tatcacagaa cccagtgtcg     7680

gtaggtatat ctgtcatgct gggggtgggg gcgattgccg cgcacaatgc cattgagtct     7740

agtgaacaaa aaaggaccct gttgatgaaa gtgtttgtaa aaaacttcct ggaccaggcg     7800

gcaacagatg agctggtaaa ggaaaaccca gagaaaataa taatggccct atttgaagca     7860

gtccagacaa ttggcaaccc cttgaggctc atatatcacc tgtatggggt ttactacaaa     7920

ggctgggaag caaaagaact atcagagaga acagcaggca ggaacctgtt caccttgata     7980

atgttcgaag ccttcgagct actagggatg gactctgaag ggaagataag gaacctgtct     8040

gggaattatg tcctggattt gatctacagc ctacataaac agataaatag aggcttgaaa     8100

aaaatagtct tggggtgggc tcccgcacca tttagttgcg actggactcc tagtgatgag     8160

agaattaggt tacccacaaa caactatcta agagtagaaa ctaagtgtcc atgtggctat     8220

gagatgaaag cactaaggaa cgttggtggc agtcttacca aagtggagga gaaaggacct     8280

tttctctgca ggaacaggct tggtagaggg ccggtcaact atagagtcac aaagtactat     8340

gatgacaacc tcaaagagat aaaaccagtt gctaaactag aaggatttgt ggatcactat     8400

tacaaaggtg ttacagcaag gatagattat ggcagaggga aaatgctatt agctactgat     8460

aaatgggagg tggagcacgg tgttgtcact aggttggcaa agagatatac cggagttgga     8520

ttcaagggag catacctggg tgatgaaccc aaccaccgcg acctagtaga aagagactgt     8580

gcaactataa caaaaaatac agtgcagttt ttaaaaatga agaaaggctg tgcatttacc     8640

tatgacttaa ccctgtccaa tttaaccagg ttaattgaat tggtacacaa aaataaccta     8700

gaagagaaag acataccagc agccacagta acgacatggc tggcttatac ttttgtaaat     8760

gaagatattg ggactataaa accagtacta ggagagagag tggtcaccga cccagtggtg     8820

gatgttaact tacaaccaga agtacaagtg gatacatcag aggttgggat cactttagtt     8880

ggtagggcag ccttaatgac gacaggtact acacccgtag tcgaaaaaac agagcccaat     8940

gctgatggtg gtccaagctc cataaagatt gggttggatg aaggaagata cccaggacct     9000

ggactgcaag accgcacctt gaccgatgaa atacattcta gggatgaaag gccctttgtt     9060

ctagtcctgg gctcaaaaaa ttctatgtca aatagagcta aaactgctag aaacatcaac     9120

ttatacaagg ggaataaccc cagggagatt agagatctga tggcacaggg gcgtatgcta     9180

gttgtggcct taaaggattt taaccctgag ttgtctgaac tagttgattt caaggggact     9240

ttcttagaca gggaagcctt ggaagctctc agcctggggc ggccaaagtc caagcaggtg     9300

accacagcca cagttaggga gttattagag caggaggtac aagttgagat ccccagttgg     9360

tttggagcag gtgatccagt cttcttggaa gtgactttga agggtgacag atatcactta     9420

gtaggagatg tagatagagt gaaagatcaa gcgaaggagc ttggggccac ggaccagaca     9480

agaatagtga aggaagtggg tgcaagaacc tataccatga agctgtctag ttggtttctt     9540

caggcaacaa ataaacagat gagcttgacc cctttatttg aggagctatt gctacgttgc     9600

ccccctaaaa taaagagcaa taaagggcac atggcatcag cttaccaact agcacaggga     9660

aactgggagc cccttgactg tggagttcac ctgggcacca tacctgccag gagggtaaaa     9720

atccacccat atgaagctta cctgaaactg aaggatttat tggaagaaga agaaaagaaa     9780

ccaaagtgta gagacacagt aataagagaa cacaacaagt ggatcctcaa aaaagtgagg     9840

caccagggta atctcaatac aaagaaaatc ctcaaccctg gaaagctatc agaacagcta     9900

gatagagaag ggcataaaag aaacatttat aacaatcaga ttggcaccat aatgacggaa     9960

gcaggaagta ggttggaaaa attaccagtc gtcagagccc aaactgacac taaaagcttc    10020

catgaggcaa tcagagataa gatagacaag aatgaaaatc agcagagccc aggactgcat    10080

gataaattgt tagagatctt tcatacaata gcccaaccca gcctaagaca cacctacagt    10140

gacgtgacgt gggagcaact tgaggcaggg gttaatagaa agggggctgc tggctttcta    10200

gagaagaaga atgttggaga agtactggac tcagagaagc acctggtgga acaactgatc    10260

agagatttga aaacaggaag gaagataaga tattatgaga cagcaatacc aaaaaatgag    10320

aagagagatg tcagtgatga ttggcaatca ggggacttag tagatgagaa gaaaccaagg    10380

gtgattcaat accctgaagc taaaacaaga ctagccatca ctaaagtaat gtacaactgg    10440

gtgaaacagc agcccgtcgt gatcccaggg tatgaaggga agaccccatt atttaacatt    10500

ttcaacaagg tgaggaagga atgggatttg ttcaatgaac cagtagctgt gagtttcgac    10560

actaaggctt gggacaccca agtaactagt agagatctac ggcttattgg tgaaattcaa    10620

aaatattact acaggaaaga gtggcacaaa ttcatcgata ccattactga ccatatggtg    10680

gaggtgcccg tcataacggc agatggtgag gtatacataa gaaatggaca aaggggtagt    10740

ggccagccag acacaagtgc aggcaatagc atgctaaacg tgttaacaat gatgtatgcc    10800

ttctgtgaaa gtacgggggt tccatacaag agtttcaata gggttgcaag gatccatgtc    10860

tgtggggatg acggcttcct aataacagag aaggggctgg gattaaagtt tgccaacaat    10920

gggatgcaaa ttctgcacga agcaggcaag cctcaaaaga taactgaggg ggaaagaatg    10980

aaagttgcct ataggttcga ggacatagaa ttctgctctc atacaccagt ccccgttagg    11040

tggtctgata acaccagcag ttacatggcc ggcagagaca ctgccgttat attatcaaag    11100

atggcaacaa gattggattc aagtggagaa aggggtacta tagcatatga aaaagcagtg    11160

gcctttagtt ttttgctgat gtactcctgg aatcctcttg tgaggaggat ctgtctactg    11220

gtcctttcac agcagccaga gacaactcca tcaacccaga ccacttacta ttataaagga    11280

gacccaatag gagcctacaa agatgtaata ggtaagaatt tgtgtgaatt aaaaaggacg    11340

ggttttgaaa aattggccaa tttaaaccta agcctgtcca cgttaggaat ctggtccaaa    11400

catacaagta aaagaatcat ccaagactgt gtaaccatcg ggaaagagga aggcaattgg    11460

ctggtcaatg ccgacaggtt gatatctagc aaaactggcc atttgtacat acctgacaaa    11520

ggttatacat tacaagggaa acattatgaa caacttcaac tgcaggcaag aactagccca    11580

gtcacgggag tagggacgga gagatataaa ctaggcccta tagtaaacct gctgctgagg    11640

aggttgagag ttctgcttat ggcagctgtc ggtgccagca gttgaaataa tgtatgtata    11700

tattgtatat aaatctgtat ttgtatatat tatgtttaaa tttagttgag attagtagtg    11760

atatatagtt atctacctca agctaacact acactcaatg cacacagcac tttagctgta    11820

tgagggtaca cccgacgtca cccccggggg atccactagt tctagagcgg ccattgaaaa    11880

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt    11940

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag    12000

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt    12060

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg    12120

gtattatccc gtgttgacgc cgggcaagag caactcggtc gccgcataca ctattctcag    12180

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta    12240

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg    12300

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta    12360

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac    12420

accacgatgc ctgcagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt    12480

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca    12540

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag    12600

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta    12660

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag    12720

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt    12780

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat    12840

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agacccctta    12900

ataagatgat cttcttgaga tcgttttggt ctgcgcgtaa tctcttgctc tgaaaacgaa    12960

aaaaccgcct tgcagggcgg tttttcgaag gttctctgag ctaccaactc tttgaaccga    13020

ggtaactggc ttggaggagc gcagtcacca aaacttgtcc tttcagttta gccttaaccg    13080

gcgcatgact tcaagactaa ctcctctaaa tcaattacca gtggctgctg ccagtggtgc    13140

ttttgcatgt ctttccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc    13200

ggactgaacg gggggttcgt gcatacagtc cagcttggag cgaactgcct acccggaact    13260

gagtgtcagg cgtggaatga gacaaacgcg gccataacag cggaatgaca ccggtaaacc    13320

gaaaggcagg aacaggagag cgcacgaggg agccgccagg gggaaacgcc tggtatcttt    13380

atagtcctgt cgggtttcgc caccactgat ttgagcgtca gatttcgtga tgcttgtcag    13440

gggggcggag cctatggaaa aacggctttg ccgcggccct ctcacttccc tgttaagtat    13500

cttcctggca tcttccagga aatctccgcc ccgttcgtaa gccatttccg ctcgccgcag    13560

tcgaacgacc gagcgtagcg agtcagtgag cgaggaagcg gaatatatcc tgtatcacat    13620

attctgctga cgcaccggtg cagccttttt tctcctgcca catgaagcac ttcactgaca    13680

ccctcatcag tgccaacata gtaagccagt atacactccg ctagaactag tggatcccgc    13740

gcg                                                                  13743


