                           б

<110> տҽҩƼ޹˾	
<120> вڻԵ鲹HCFH-򵰰ףIgںϵ
ƱӦ
<130> CPB165190W

<160>  14

<210>  1
<211>  1213
<212>  PRT
<213>  ȫCFH

<400>  1
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 
Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     
Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         
His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             
Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 
Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 
Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     
Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         
Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             
Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 
Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 
Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     
Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         
Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             
Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 
Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 
Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     
Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         
Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             
Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 
Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 
Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     
Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         
Gly Glu Gln Val Thr Tyr Thr Cys  Ala Thr Tyr Tyr Lys  Met Asp Gly 
        995                 1000                 1005             
Ala Ser  Asn Val Thr Cys Ile  Asn Ser Arg Trp Thr  Gly Arg Pro 
    1010                 1015                 1020             
Thr Cys  Arg Asp Thr Ser Cys  Val Asn Pro Pro Thr  Val Gln Asn 
    1025                 1030                 1035             
Ala Tyr  Ile Val Ser Arg Gln  Met Ser Lys Tyr Pro  Ser Gly Glu 
    1040                 1045                 1050             
Arg Val  Arg Tyr Gln Cys Arg  Ser Pro Tyr Glu Met  Phe Gly Asp 
    1055                 1060                 1065             
Glu Glu  Val Met Cys Leu Asn  Gly Asn Trp Thr Glu  Pro Pro Gln 
    1070                 1075                 1080             
Cys Lys  Asp Ser Thr Gly Lys  Cys Gly Pro Pro Pro  Pro Ile Asp 
    1085                 1090                 1095             
Asn Gly  Asp Ile Thr Ser Phe  Pro Leu Ser Val Tyr  Ala Pro Ala 
    1100                 1105                 1110             
Ser Ser  Val Glu Tyr Gln Cys  Gln Asn Leu Tyr Gln  Leu Glu Gly 
    1115                 1120                 1125             
Asn Lys  Arg Ile Thr Cys Arg  Asn Gly Gln Trp Ser  Glu Pro Pro 
    1130                 1135                 1140             
Lys Cys  Leu His Pro Cys Val  Ile Ser Arg Glu Ile  Met Glu Asn 
    1145                 1150                 1155             
Tyr Asn  Ile Ala Leu Arg Trp  Thr Ala Lys Gln Lys  Leu Tyr Ser 
    1160                 1165                 1170             
Arg Thr  Gly Glu Ser Val Glu  Phe Val Cys Lys Arg  Gly Tyr Arg 
    1175                 1180                 1185             
Leu Ser  Ser Arg Ser His Thr  Leu Arg Thr Thr Cys  Trp Asp Gly 
    1190                 1195                 1200             
Lys Leu  Glu Tyr Pro Thr Cys  Ala Lys Arg 
    1205                 1210             

<210>  2
<211>  246
<212>  PRT
<213>  CFH SCR (1-4)
<400>  2
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu 
                245     

<210>  3
<211>  424
<212>  PRT
<213>  CFH SCR (1-7)
<400>  3
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
305                 310                 315                 320 
Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
                325                 330                 335     
Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
            340                 345                 350         
Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg 
        355                 360                 365             
Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
    370                 375                 380                 
Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
385                 390                 395                 400 
Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
                405                 410                 415     
Trp Ser Pro Thr Pro Arg Cys Ile 
            420                 

<210>  4
<211>  187
<212>  PRT
<213>  CFH SCR (18-20)
<400>  4
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
1               5                   10                  15      
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
            20                  25                  30          
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
        35                  40                  45              
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
    50                  55                  60                  
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
65                  70                  75                  80  
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
                85                  90                  95      
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
            100                 105                 110         
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
        115                 120                 125             
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
    130                 135                 140                 
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
145                 150                 155                 160 
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
                165                 170                 175     
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            180                 185         

<210>  5
<211>  127
<212>  PRT
<213>  CFH SCR (19-20)
<400>  5
Asp Ser Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
1               5                   10                  15      
Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
            20                  25                  30          
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
        35                  40                  45              
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
    50                  55                  60                  
Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
65                  70                  75                  80  
Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
                85                  90                  95      
Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
            100                 105                 110         
Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
        115                 120                 125         

<210>  6
<211>  229
<212>  PRT
<213>  򵰰IgG1 Fc
<400>  6
Val Pro Arg Asn Cys Gly Gly Asp Cys Lys Pro Cys Ile Cys Thr Gly 
1               5                   10                  15      
Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp Val 
            20                  25                  30          
Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
        35                  40                  45              
Ser Gln Asn Asp Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp Val 
    50                  55                  60                  
Glu Val His Thr Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn Ser 
65                  70                  75                  80  
Thr Leu Arg Ser Val Ser Glu Leu Pro Ile Val His Arg Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Thr Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro Ala 
            100                 105                 110         
Pro Ile Glu Lys Ser Ile Ser Lys Pro Glu Gly Arg Thr Gln Val Pro 
        115                 120                 125             
His Val Tyr Thr Met Ser Pro Thr Lys Glu Glu Met Thr Gln Asn Glu 
    130                 135                 140                 
Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr 
145                 150                 155                 160 
Val Glu Trp Gln Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr 
                165                 170                 175     
Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         
Asn Val Lys Lys Glu Lys Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser 
        195                 200                 205             
Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
    210                 215                 220                 
His Ser Pro Gly Lys 
225  

<210>  7
<211>  227
<212>  PRT
<213>  С򵰰IgG1 Fc
<400>  7
Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      
Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          
Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              
Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  
His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Ala Ser Thr Phe 
65                  70                  75                  80  
Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             
Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 
Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 
Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     
Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         
Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             
His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 
Pro Gly Lys 
225         

<210>  8
<211>  232
<212>  PRT
<213>  ˵򵰰IgG1 Fc
<400>  8
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  9
<211>  656
<212>  PRT
<213>  ںϵhSCR (1-7)-hFc
<400>  9
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
305                 310                 315                 320 
Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
                325                 330                 335     
Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
            340                 345                 350         
Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg 
        355                 360                 365             
Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
    370                 375                 380                 
Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
385                 390                 395                 400 
Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
                405                 410                 415     
Trp Ser Pro Thr Pro Arg Cys Ile Glu Pro Lys Ser Cys Asp Lys Thr 
            420                 425                 430         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        435                 440                 445             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    450                 455                 460                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
465                 470                 475                 480 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                485                 490                 495     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            500                 505                 510         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        515                 520                 525             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    530                 535                 540                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
545                 550                 555                 560 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                565                 570                 575     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            580                 585                 590         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        595                 600                 605             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    610                 615                 620                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
625                 630                 635                 640 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655     

<210>  10
<211>  652
<212>  PRT
<213>  ںϵhSCR (1-7)-mFc
<400>  10
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 
Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     
Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         
His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             
Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn His 
    370                 375                 380                 
Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 
Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     
Gly Trp Ser Pro Thr Pro Arg Cys Ile Val Pro Arg Asp Cys Gly Cys 
            420                 425                 430         
Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
        435                 440                 445             
Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
    450                 455                 460                 
Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
465                 470                 475                 480 
Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
                485                 490                 495     
Arg Glu Glu Gln Phe Ala Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
            500                 505                 510         
Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
        515                 520                 525             
Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
    530                 535                 540                 
Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
545                 550                 555                 560 
Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
                565                 570                 575     
Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
            580                 585                 590         
Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
        595                 600                 605             
Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
    610                 615                 620                 
Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
625                 630                 635                 640 
His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                645                 650         
<210>  11
<211>  611
<212>  PRT
<213>  ںϵhSCR (1-7)-hSCR (18-20)-hFc
<400>  11
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
305                 310                 315                 320 
Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
                325                 330                 335     
Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
            340                 345                 350         
Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg 
        355                 360                 365             
Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
    370                 375                 380                 
Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
385                 390                 395                 400 
Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
                405                 410                 415     
Trp Ser Pro Thr Pro Arg Cys Ile Asp Thr Ser Cys Val Asn Pro Pro 
            420                 425                 430         
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
        435                 440                 445             
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
    450                 455                 460                 
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
465                 470                 475                 480 
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
                485                 490                 495     
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
            500                 505                 510         
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
        515                 520                 525             
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
    530                 535                 540                 
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
545                 550                 555                 560 
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
                565                 570                 575     
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
            580                 585                 590         
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
        595                 600                 605             
Ala Lys Arg 
    610     

<210>  12
<211>  2079
<212>  DNA
<213>  ںϻXho I-CFHź-hSCR (1-7)-hFc-6His-Xba I 
<400>  12
ctcgagatga gacttctagc aaagattatt tgccttatgt tatgggctat ttgtgtagca       60
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct      120
gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      180
cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      240
aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      300
acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      360
caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      420
cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      480
agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      540
aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      600
agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      660
tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      720
atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      780
ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      840
cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      900
tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      960
agatgtacct tgaaaccttg tgattatcca gacattaaac atggaggtct atatcatgag     1020
aatatgcgta gaccatactt tccagtagct gtaggaaaat attactccta ttactgtgat     1080
gaacattttg agactccgtc aggaagttac tgggatcaca ttcattgcac acaagatgga     1140
tggtcgccag cagtaccatg cctcagaaaa tgttattttc cttatttgga aaatggatat     1200
aatcaaaatc atggaagaaa gtttgtacag ggtaaatcta tagacgttgc ctgccatcct     1260
ggctacgctc ttccaaaagc gcagaccaca gttacatgta tggagaatgg ctggtctcct     1320
actcccagat gcatcgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca     1380
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1440
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1500
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1560
ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac     1620
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1680
cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1740
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1800
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1860
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1920
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1980
gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa agagaacctg     2040
tacttccagg gacaccacca ccaccaccac tagtctaga                            2079

<210>  13
<211>  2064
<212>  DNA
<213>  ںϻXho I-CFHź-hSCR (1-7)-mFc-6His-Xba I
<400>  13
ctcgagatga gacttctagc aaagattatt tgccttatgt tatgggctat ttgtgtagca        60
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct       120
gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct       180
cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg       240
aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt       300
acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat       360
caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt       420
cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc       480
agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt       540
aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg       600
agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga       660
tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac       720
atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg       780
ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca       840
cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt       900
tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg       960
agatgtacct tgaaaccttg tgattatcca gacattaaac atggaggtct atatcatgag      1020
aatatgcgta gaccatactt tccagtagct gtaggaaaat attactccta ttactgtgat      1080
gaacattttg agactccgtc aggaagttac tgggatcaca ttcattgcac acaagatgga      1140
tggtcgccag cagtaccatg cctcagaaaa tgttattttc cttatttgga aaatggatat      1200
aatcaaaatc atggaagaaa gtttgtacag ggtaaatcta tagacgttgc ctgccatcct      1260
ggctacgctc ttccaaaagc gcagaccaca gttacatgta tggagaatgg ctggtctcct      1320
actcccagat gcatcgtgcc cagggattgt ggttgtaagc cttgcatatg tacagtccca      1380
gaagtatcat ctgtcttcat cttcccccca aagcccaagg atgtgctcac cattactctg      1440
actcctaagg tcacgtgtgt tgtggtagac atcagcaagg atgatcccga ggtccagttc      1500
agctggtttg tagatgatgt ggaggtgcac acagctcaga cgcaaccccg ggaggagcag      1560
ttcgctagca ctttccgctc agtcagtgaa cttcccatca tgcaccagga ctggctcaat      1620
ggcaaggagt tcaaatgcag ggtaaacagt gcagctttcc ctgcccccat cgagaaaacc      1680
atctccaaaa ccaaaggcag accgaaggct ccacaggtgt acaccattcc acctcccaag      1740
gagcagatgg ccaaggataa agtcagtctg acctgcatga taacagactt cttccctgaa      1800
gacattactg tggagtggca gtggaatggg cagccagcgg agaactacaa gaacactcag      1860
cccatcatgg acacagatgg ctcttacttc gtctacagca agctcaatgt gcagaagagc      1920
aactgggagg caggaaatac tttcacctgc tctgtgttac atgagggcct gcacaaccac      1980
catactgaga agagcctctc ccactctcct ggtaaagaga acctgtactt ccagggacac      2040
caccaccacc accactagtc taga                                            2064

<210>  14
<211>  2640
<212>  DNA
<213> ںϻXho I-CFHź-hSCR (1-7)-hSCR (18-20)-hFc-6His-Xba I
<400>  14
ctcgagatga gacttctagc aaagattatt tgccttatgt tatgggctat ttgtgtagca       60
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct      120
gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      180
cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      240
aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      300
acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      360
caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      420
cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      480
agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      540
aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      600
agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      660
tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      720
atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      780
ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      840
cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      900
tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      960
agatgtacct tgaaaccttg tgattatcca gacattaaac atggaggtct atatcatgag     1020
aatatgcgta gaccatactt tccagtagct gtaggaaaat attactccta ttactgtgat     1080
gaacattttg agactccgtc aggaagttac tgggatcaca ttcattgcac acaagatgga     1140
tggtcgccag cagtaccatg cctcagaaaa tgttattttc cttatttgga aaatggatat     1200
aatcaaaatc atggaagaaa gtttgtacag ggtaaatcta tagacgttgc ctgccatcct     1260
ggctacgctc ttccaaaagc gcagaccaca gttacatgta tggagaatgg ctggtctcct     1320
actcccagat gcatcgacac ctcctgtgtg aatccgccca cagtacaaaa tgcttatata     1380
gtgtcgagac agatgagtaa atatccatct ggtgagagag tacgttatca atgtaggagc     1440
ccttatgaaa tgtttgggga tgaagaagtg atgtgtttaa atggaaactg gacggaacca     1500
cctcaatgca aagattctac aggaaaatgt gggccccctc cacctattga caatggggac     1560
attacttcat tcccgttgtc agtatatgct ccagcttcat cagttgagta ccaatgccag     1620
aacttgtatc aacttgaggg taacaagcga ataacatgta gaaatggaca atggtcagaa     1680
ccaccaaaat gcttacatcc gtgtgtaata tcccgagaaa ttatggaaaa ttataacata     1740
gcattaaggt ggacagccaa acagaagctt tattcgagaa caggtgaatc agttgaattt     1800
gtgtgtaaac ggggatatcg tctttcatca cgttctcaca cattgcgaac aacatgttgg     1860
gatgggaaac tggagtatcc aacttgtgca aaaagagagc ccaaatcttg tgacaaaact     1920
cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc     1980
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     2040
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     2100
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc     2160
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     2220
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     2280
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     2340
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     2400
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     2460
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     2520
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2580
tctccgggta aagagaacct gtacttccag ggacaccacc accaccacca ctagtctaga     2640







