
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Adaptive Biotechnologies Corporation
      Schmitt, Thomas M.
      Greenberg, Philip D.
      Chapuis, Aude G.
      Robins, Harlan S.
      Sherwood, Anna M.

<120> HIGH AFFINITY T CELL RECEPTORS AND USES
  THEREOF

<130> 360056.439WO

<140> US                  
<141> 2016-12-23  

<150> US 62/387,546       
<151> 2015-12-23  

<160> 258

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201alpha chain variable domain

<400> 1
Met Asn Ser Ser Leu Asp Phe Leu Ile Leu Ile Leu Met Phe Gly Gly
 1               5                  10                  15
Thr Ser Ser Asn Ser Val Lys Gln Thr Gly Gln Ile Thr Val Ser Glu
            20                  25                  30
Gly Ala Ser Val Thr Met Asn Cys Thr Tyr Thr Ser Thr Gly Tyr Pro
        35                  40                  45
Thr Leu Phe Trp Tyr Val Glu Tyr Pro Ser Lys Pro Leu Gln Leu Leu
    50                  55                  60
Gln Arg Glu Thr Met Glu Asn Ser Lys Asn Phe Gly Gly Gly Asn Ile
65                  70                  75                  80
Lys Asp Lys Asn Ser Pro Ile Val Lys Tyr Ser Val Gln Val Ser Asp
                85                  90                  95
Ser Ala Val Tyr Tyr Cys Leu Leu Arg Asn His Asp Lys Leu Ile Phe
            100                 105                 110
Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn
        115                 120

<210> 2
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201alpha  chain constant domain

<400> 2
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 3
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201alpha (T170C) chain constant domain

<400> 3
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 4
<211> 263
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201alpha chain

<400> 4
Met Asn Ser Ser Leu Asp Phe Leu Ile Leu Ile Leu Met Phe Gly Gly
 1               5                  10                  15
Thr Ser Ser Asn Ser Val Lys Gln Thr Gly Gln Ile Thr Val Ser Glu
            20                  25                  30
Gly Ala Ser Val Thr Met Asn Cys Thr Tyr Thr Ser Thr Gly Tyr Pro
        35                  40                  45
Thr Leu Phe Trp Tyr Val Glu Tyr Pro Ser Lys Pro Leu Gln Leu Leu
    50                  55                  60
Gln Arg Glu Thr Met Glu Asn Ser Lys Asn Phe Gly Gly Gly Asn Ile
65                  70                  75                  80
Lys Asp Lys Asn Ser Pro Ile Val Lys Tyr Ser Val Gln Val Ser Asp
                85                  90                  95
Ser Ala Val Tyr Tyr Cys Leu Leu Arg Asn His Asp Lys Leu Ile Phe
            100                 105                 110
Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn Ile Gln Asn Pro Asp
        115                 120                 125
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val
    130                 135                 140
Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys
145                 150                 155                 160
Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser
                165                 170                 175
Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp
            180                 185                 190
Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr
        195                 200                 205
Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys
    210                 215                 220
Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile
225                 230                 235                 240
Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met
                245                 250                 255
Thr Leu Arg Leu Trp Ser Ser
            260

<210> 5
<211> 263
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201alpha (T170C) chain

<400> 5
Met Asn Ser Ser Leu Asp Phe Leu Ile Leu Ile Leu Met Phe Gly Gly
 1               5                  10                  15
Thr Ser Ser Asn Ser Val Lys Gln Thr Gly Gln Ile Thr Val Ser Glu
            20                  25                  30
Gly Ala Ser Val Thr Met Asn Cys Thr Tyr Thr Ser Thr Gly Tyr Pro
        35                  40                  45
Thr Leu Phe Trp Tyr Val Glu Tyr Pro Ser Lys Pro Leu Gln Leu Leu
    50                  55                  60
Gln Arg Glu Thr Met Glu Asn Ser Lys Asn Phe Gly Gly Gly Asn Ile
65                  70                  75                  80
Lys Asp Lys Asn Ser Pro Ile Val Lys Tyr Ser Val Gln Val Ser Asp
                85                  90                  95
Ser Ala Val Tyr Tyr Cys Leu Leu Arg Asn His Asp Lys Leu Ile Phe
            100                 105                 110
Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn Ile Gln Asn Pro Asp
        115                 120                 125
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val
    130                 135                 140
Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys
145                 150                 155                 160
Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser
                165                 170                 175
Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp
            180                 185                 190
Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr
        195                 200                 205
Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys
    210                 215                 220
Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile
225                 230                 235                 240
Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met
                245                 250                 255
Thr Leu Arg Leu Trp Ser Ser
            260

<210> 6
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201beta chain variable domain

<400> 6
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Asp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu
    130

<210> 7
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201beta chain constant domain

<400> 7
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 8
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201beta (S188C) chain constant domain

<400> 8
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 9
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201beta chain

<400> 9
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Asp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 10
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201 beta (S188C) chain

<400> 10
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Asp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 11
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201beta (S188C)-P2A-ME201alpha (T170C)

<400> 11
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Asp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asn Ser Ser
                325                 330                 335
Leu Asp Phe Leu Ile Leu Ile Leu Met Phe Gly Gly Thr Ser Ser Asn
            340                 345                 350
Ser Val Lys Gln Thr Gly Gln Ile Thr Val Ser Glu Gly Ala Ser Val
        355                 360                 365
Thr Met Asn Cys Thr Tyr Thr Ser Thr Gly Tyr Pro Thr Leu Phe Trp
    370                 375                 380
Tyr Val Glu Tyr Pro Ser Lys Pro Leu Gln Leu Leu Gln Arg Glu Thr
385                 390                 395                 400
Met Glu Asn Ser Lys Asn Phe Gly Gly Gly Asn Ile Lys Asp Lys Asn
                405                 410                 415
Ser Pro Ile Val Lys Tyr Ser Val Gln Val Ser Asp Ser Ala Val Tyr
            420                 425                 430
Tyr Cys Leu Leu Arg Asn His Asp Lys Leu Ile Phe Gly Thr Gly Thr
        435                 440                 445
Arg Leu Gln Val Phe Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
    450                 455                 460
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
465                 470                 475                 480
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                485                 490                 495
Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys
            500                 505                 510
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
        515                 520                 525
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
    530                 535                 540
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
545                 550                 555                 560
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                565                 570                 575
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
            580                 585                 590
Trp Ser Ser
        595

<210> 12
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301alpha chain variable domain

<400> 12
Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu
 1               5                  10                  15
Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln
            20                  25                  30
Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp
        35                  40                  45
Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu
    50                  55                  60
Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met
65                  70                  75                  80
Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala
                85                  90                  95
Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Gly Asn Tyr
            100                 105                 110
Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser
        115                 120                 125
Val Lys Pro Asn
    130

<210> 13
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301alpha chain

<400> 13
Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu
 1               5                  10                  15
Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln
            20                  25                  30
Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp
        35                  40                  45
Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu
    50                  55                  60
Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met
65                  70                  75                  80
Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala
                85                  90                  95
Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Gly Asn Tyr
            100                 105                 110
Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser
        115                 120                 125
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 14
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301alpha (T179C) chain

<400> 14
Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu
 1               5                  10                  15
Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln
            20                  25                  30
Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp
        35                  40                  45
Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu
    50                  55                  60
Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met
65                  70                  75                  80
Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala
                85                  90                  95
Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Gly Asn Tyr
            100                 105                 110
Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser
        115                 120                 125
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 15
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301beta chain variable domain

<400> 15
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ala Gly Gly Tyr Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu
    130

<210> 16
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301beta chain

<400> 16
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ala Gly Gly Tyr Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 17
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301 beta (S190C) chain

<400> 17
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ala Gly Gly Tyr Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 18
<211> 606
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301 beta (S190C)-P2A-ME5301 alpha (T179C)

<400> 18
Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His
        35                  40                  45
Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro
65                  70                  75                  80
Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ala Gly Gly Tyr Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser
305                 310                 315                 320
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys
                325                 330                 335
Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu Ser Gly
            340                 345                 350
Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln Glu Gly
        355                 360                 365
Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp Arg Leu
    370                 375                 380
Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val
385                 390                 395                 400
Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met Ala Ser
                405                 410                 415
Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala Ala Val
            420                 425                 430
His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Gly Asn Tyr Gly Gly
        435                 440                 445
Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys
    450                 455                 460
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
465                 470                 475                 480
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
                485                 490                 495
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
            500                 505                 510
Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
        515                 520                 525
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
    530                 535                 540
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
545                 550                 555                 560
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
                565                 570                 575
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
            580                 585                 590
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 19
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain variable domain

<400> 19
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys
        115                 120                 125
Gly Thr Lys Leu Ser Val Lys Pro Asn
    130                 135

<210> 20
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain

<400> 20
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys
        115                 120                 125
Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala
    130                 135                 140
Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
145                 150                 155                 160
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
                165                 170                 175
Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp
            180                 185                 190
Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala
        195                 200                 205
Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe
    210                 215                 220
Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe
225                 230                 235                 240
Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe
                245                 250                 255
Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu
            260                 265                 270
Arg Leu Trp Ser Ser
        275

<210> 21
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 alpha (T184C) chain

<400> 21
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys
        115                 120                 125
Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala
    130                 135                 140
Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
145                 150                 155                 160
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
                165                 170                 175
Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp
            180                 185                 190
Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala
        195                 200                 205
Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe
    210                 215                 220
Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe
225                 230                 235                 240
Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe
                245                 250                 255
Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu
            260                 265                 270
Arg Leu Trp Ser Ser
        275

<210> 22
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 beta chain variable domain

<400> 22
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile
            20                  25                  30
Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His
        35                  40                  45
Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu
    50                  55                  60
Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro
65                  70                  75                  80
Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Thr Glu
    130

<210> 23
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 beta chain

<400> 23
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile
            20                  25                  30
Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His
        35                  40                  45
Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu
    50                  55                  60
Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro
65                  70                  75                  80
Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 24
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 beta (S188C) chain

<400> 24
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile
            20                  25                  30
Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His
        35                  40                  45
Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu
    50                  55                  60
Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro
65                  70                  75                  80
Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 25
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 beta (S188C)-P2A-WT374 alpha (T184C)

<400> 25
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile
            20                  25                  30
Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His
        35                  40                  45
Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu
    50                  55                  60
Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro
65                  70                  75                  80
Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Met Leu
                325                 330                 335
Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro Asp Trp Val Asn
            340                 345                 350
Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln Asn Ser Pro Ser
        355                 360                 365
Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn Cys Asp Tyr Thr
    370                 375                 380
Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys Tyr Pro Ala Glu
385                 390                 395                 400
Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys Asp Lys Asn Glu
                405                 410                 415
Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala Lys His Leu Ser
            420                 425                 430
Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys
        435                 440                 445
Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu
    450                 455                 460
Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
465                 470                 475                 480
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
                485                 490                 495
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
            500                 505                 510
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
        515                 520                 525
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
    530                 535                 540
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
545                 550                 555                 560
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
                565                 570                 575
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
            580                 585                 590
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
        595                 600                 605
Ser


<210> 26
<211> 138
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain variable domain

<400> 26
Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser
 1               5                  10                  15
Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val
            20                  25                  30
Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly
        35                  40                  45
Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln
    50                  55                  60
Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys
                85                  90                  95
Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val
            100                 105                 110
Arg Asp Ile Arg Tyr Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly
        115                 120                 125
Lys Gly Thr Lys Leu Ser Val Lys Pro Asn
    130                 135

<210> 27
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain

<400> 27
Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser
 1               5                  10                  15
Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val
            20                  25                  30
Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly
        35                  40                  45
Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln
    50                  55                  60
Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys
                85                  90                  95
Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val
            100                 105                 110
Arg Asp Ile Arg Tyr Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly
        115                 120                 125
Lys Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro
    130                 135                 140
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
145                 150                 155                 160
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                165                 170                 175
Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met
            180                 185                 190
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        195                 200                 205
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    210                 215                 220
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
225                 230                 235                 240
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                245                 250                 255
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            260                 265                 270
Leu Arg Leu Trp Ser Ser
        275

<210> 28
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 alpha (T185C) chain

<400> 28
Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser
 1               5                  10                  15
Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val
            20                  25                  30
Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly
        35                  40                  45
Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln
    50                  55                  60
Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys
                85                  90                  95
Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val
            100                 105                 110
Arg Asp Ile Arg Tyr Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly
        115                 120                 125
Lys Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro
    130                 135                 140
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
145                 150                 155                 160
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                165                 170                 175
Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met
            180                 185                 190
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        195                 200                 205
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    210                 215                 220
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
225                 230                 235                 240
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                245                 250                 255
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            260                 265                 270
Leu Arg Leu Trp Ser Ser
        275

<210> 29
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 beta chain variable domain

<400> 29
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Pro Gly Pro Ser Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
        115                 120                 125
Leu Thr Val Leu Glu
    130

<210> 30
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 beta chain

<400> 30
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Pro Gly Pro Ser Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 31
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 beta (S189C) chain

<400> 31
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Pro Gly Pro Ser Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 32
<211> 611
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 beta (S189C)-P2A-WT375 alpha (T185C)

<400> 32
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Pro Gly Pro Ser Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu
305                 310                 315                 320
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser
                325                 330                 335
Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser Gly Leu Arg
            340                 345                 350
Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly
        355                 360                 365
Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr
    370                 375                 380
Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu
385                 390                 395                 400
Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu
                405                 410                 415
Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser
            420                 425                 430
Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile
        435                 440                 445
Arg Tyr Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr
    450                 455                 460
Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
465                 470                 475                 480
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
                485                 490                 495
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
            500                 505                 510
Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys
        515                 520                 525
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
    530                 535                 540
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
545                 550                 555                 560
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
                565                 570                 575
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
            580                 585                 590
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
        595                 600                 605
Trp Ser Ser
    610

<210> 33
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain variable domain

<400> 33
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro
            20                  25                  30
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys
    50                  55                  60
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp
65                  70                  75                  80
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu
                85                  90                  95
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110
Ile Tyr Gly Trp Gly Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr
        115                 120                 125
Gly Thr Leu Leu Ala Val Gln Pro Asn
    130                 135

<210> 34
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain

<400> 34
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro
            20                  25                  30
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys
    50                  55                  60
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp
65                  70                  75                  80
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu
                85                  90                  95
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110
Ile Tyr Gly Trp Gly Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr
        115                 120                 125
Gly Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala
    130                 135                 140
Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
145                 150                 155                 160
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
                165                 170                 175
Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp
            180                 185                 190
Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala
        195                 200                 205
Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe
    210                 215                 220
Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe
225                 230                 235                 240
Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe
                245                 250                 255
Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu
            260                 265                 270
Arg Leu Trp Ser Ser
        275

<210> 35
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 alpha (T184C) chain

<400> 35
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro
            20                  25                  30
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys
    50                  55                  60
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp
65                  70                  75                  80
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu
                85                  90                  95
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110
Ile Tyr Gly Trp Gly Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr
        115                 120                 125
Gly Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala
    130                 135                 140
Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
145                 150                 155                 160
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
                165                 170                 175
Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp
            180                 185                 190
Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala
        195                 200                 205
Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe
    210                 215                 220
Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe
225                 230                 235                 240
Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe
                245                 250                 255
Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu
            260                 265                 270
Arg Leu Trp Ser Ser
        275

<210> 36
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 beta chain variable domain

<400> 36
Met Gly Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr
            20                  25                  30
Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu
                85                  90                  95
Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Gly Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu
    130                 135

<210> 37
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 beta chain

<400> 37
Met Gly Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr
            20                  25                  30
Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu
                85                  90                  95
Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Gly Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 38
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 beta (S191C) chain

<400> 38
Met Gly Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr
            20                  25                  30
Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu
                85                  90                  95
Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Gly Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 39
<211> 612
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 beta (S191C)-P2A-WT378 alpha (T184C)

<400> 39
Met Gly Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr
            20                  25                  30
Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu
                85                  90                  95
Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala
            100                 105                 110
Ser Ser Leu Tyr Gly Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe
305                 310                 315                 320
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
                325                 330                 335
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
            340                 345                 350
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu
        355                 360                 365
Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn
    370                 375                 380
Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly
385                 390                 395                 400
Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly
                405                 410                 415
Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe
            420                 425                 430
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ile
        435                 440                 445
Tyr Gly Trp Gly Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly
    450                 455                 460
Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val
465                 470                 475                 480
Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
                485                 490                 495
Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
            500                 505                 510
Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe
        515                 520                 525
Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
    530                 535                 540
Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
545                 550                 555                 560
Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
                565                 570                 575
Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
            580                 585                 590
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
        595                 600                 605
Leu Trp Ser Ser
    610

<210> 40
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain variable domain

<400> 40
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Gly Gly Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys
        115                 120                 125
Leu Gln Val Ile Pro Asn
    130

<210> 41
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain

<400> 41
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Gly Gly Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys
        115                 120                 125
Leu Gln Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175
Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270
Ser Ser


<210> 42
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 alpha (T181C) chain

<400> 42
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Gly Gly Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys
        115                 120                 125
Leu Gln Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175
Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270
Ser Ser


<210> 43
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 beta chain variable domain

<400> 43
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gly Arg Ala Gly Val Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu
    130

<210> 44
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 beta chain

<400> 44
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gly Arg Ala Gly Val Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 45
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 beta (S189C) chain

<400> 45
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gly Arg Ala Gly Val Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 46
<211> 607
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 beta (S189C)-P2A-WT379 alpha (T181C)

<400> 46
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gly Arg Ala Gly Val Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu
305                 310                 315                 320
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ser
                325                 330                 335
Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp
            340                 345                 350
Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro
        355                 360                 365
Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser
    370                 375                 380
Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu
385                 390                 395                 400
Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr
                405                 410                 415
Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp
            420                 425                 430
Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Gly Gly Ser
        435                 440                 445
Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val
    450                 455                 460
Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp
465                 470                 475                 480
Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser
                485                 490                 495
Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp
            500                 505                 510
Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala
        515                 520                 525
Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn
    530                 535                 540
Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser
545                 550                 555                 560
Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu
                565                 570                 575
Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys
            580                 585                 590
Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 47
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain variable domain

<400> 47
Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe
            20                  25                  30
Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn
        35                  40                  45
Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu
    50                  55                  60
Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg
65                  70                  75                  80
Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile
                85                  90                  95
Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys
            100                 105                 110
Pro Asp Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr
        115                 120                 125
Lys Leu Ser Val Ile Pro Asn
    130                 135

<210> 48
<211> 275
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain

<400> 48
Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe
            20                  25                  30
Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn
        35                  40                  45
Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu
    50                  55                  60
Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg
65                  70                  75                  80
Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile
                85                  90                  95
Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys
            100                 105                 110
Pro Asp Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr
        115                 120                 125
Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
    130                 135                 140
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
145                 150                 155                 160
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                165                 170                 175
Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
            180                 185                 190
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
        195                 200                 205
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
    210                 215                 220
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
225                 230                 235                 240
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                245                 250                 255
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
            260                 265                 270
Trp Ser Ser
        275

<210> 49
<211> 275
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 alpha (T182C) chain

<400> 49
Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe
            20                  25                  30
Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn
        35                  40                  45
Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu
    50                  55                  60
Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg
65                  70                  75                  80
Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile
                85                  90                  95
Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys
            100                 105                 110
Pro Asp Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr
        115                 120                 125
Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
    130                 135                 140
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
145                 150                 155                 160
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                165                 170                 175
Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys
            180                 185                 190
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
        195                 200                 205
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
    210                 215                 220
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
225                 230                 235                 240
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                245                 250                 255
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
            260                 265                 270
Trp Ser Ser
        275

<210> 50
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain variable domain

<400> 50
Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly
                85                  90                  95
Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu
    130

<210> 51
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain

<400> 51
Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly
                85                  90                  95
Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 52
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 beta (S190C) chain

<400> 52
Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly
                85                  90                  95
Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 53
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 beta (S190C)-P2A-WT3710 alpha (T182C)

<400> 53
Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly
                85                  90                  95
Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser
305                 310                 315                 320
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile
                325                 330                 335
Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val
            340                 345                 350
Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val
        355                 360                 365
Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala
    370                 375                 380
Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys
385                 390                 395                 400
Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr
                405                 410                 415
Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp
            420                 425                 430
Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys Pro Asp
        435                 440                 445
Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu
    450                 455                 460
Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
465                 470                 475                 480
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
                485                 490                 495
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
            500                 505                 510
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
        515                 520                 525
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
    530                 535                 540
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
545                 550                 555                 560
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
                565                 570                 575
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
            580                 585                 590
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
        595                 600                 605
Ser


<210> 54
<211> 138
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain variable domain

<400> 54
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Met Arg Ala Arg Glu Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly
        115                 120                 125
Glu Gly Thr Gln Leu Thr Val Asn Pro Asp
    130                 135

<210> 55
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain

<400> 55
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Met Arg Ala Arg Glu Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly
        115                 120                 125
Glu Gly Thr Gln Leu Thr Val Asn Pro Asp Ile Gln Asn Pro Asp Pro
    130                 135                 140
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
145                 150                 155                 160
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                165                 170                 175
Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met
            180                 185                 190
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        195                 200                 205
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    210                 215                 220
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
225                 230                 235                 240
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                245                 250                 255
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            260                 265                 270
Leu Arg Leu Trp Ser Ser
        275

<210> 56
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 alpha (T185C) chain

<400> 56
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Met Arg Ala Arg Glu Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly
        115                 120                 125
Glu Gly Thr Gln Leu Thr Val Asn Pro Asp Ile Gln Asn Pro Asp Pro
    130                 135                 140
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
145                 150                 155                 160
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                165                 170                 175
Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met
            180                 185                 190
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        195                 200                 205
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    210                 215                 220
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
225                 230                 235                 240
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                245                 250                 255
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            260                 265                 270
Leu Arg Leu Trp Ser Ser
        275

<210> 57
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta chain variable domain

<400> 57
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Gln Asp Gly Arg Ser Arg Pro Gln His Phe Gly Asp Gly Thr Arg
        115                 120                 125
Leu Ser Ile Leu Glu
    130

<210> 58
<211> 176
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta chain constant domain

<400> 58
Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
                165                 170                 175

<210> 59
<211> 176
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta (S189C) chain constant domain

<400> 59
Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
                165                 170                 175

<210> 60
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta chain

<400> 60
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Gln Asp Gly Arg Ser Arg Pro Gln His Phe Gly Asp Gly Thr Arg
        115                 120                 125
Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe
305

<210> 61
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta (S189C) chain

<400> 61
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Gln Asp Gly Arg Ser Arg Pro Gln His Phe Gly Asp Gly Thr Arg
        115                 120                 125
Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 62
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta (S189C)-P2A-WT371 alpha (T185C)

<400> 62
Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala
 1               5                  10                  15
Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr
            20                  25                  30
Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His
        35                  40                  45
Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile
    50                  55                  60
Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro
65                  70                  75                  80
Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His
                85                  90                  95
Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Gln Asp Gly Arg Ser Arg Pro Gln His Phe Gly Asp Gly Thr Arg
        115                 120                 125
Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Leu Ser Ser
                325                 330                 335
Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu Gly Pro Gly Ile Ala
            340                 345                 350
Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys Glu
        355                 360                 365
Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr Gly
    370                 375                 380
Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile
385                 390                 395                 400
Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr Ser
                405                 410                 415
Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser Ala
            420                 425                 430
Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Ala Arg
        435                 440                 445
Glu Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu
    450                 455                 460
Thr Val Asn Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
465                 470                 475                 480
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
                485                 490                 495
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
            500                 505                 510
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
        515                 520                 525
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
    530                 535                 540
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
545                 550                 555                 560
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
                565                 570                 575
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
            580                 585                 590
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
        595                 600                 605
Ser


<210> 63
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain variable domain

<400> 63
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Pro Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu
        115                 120                 125
Lys Val Leu Ala Asn
    130

<210> 64
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain

<400> 64
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Pro Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu
        115                 120                 125
Lys Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
    130                 135                 140
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
145                 150                 155                 160
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
                165                 170                 175
Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
            180                 185                 190
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
        195                 200                 205
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
    210                 215                 220
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
225                 230                 235                 240
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
                245                 250                 255
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
            260                 265                 270
Ser


<210> 65
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 alpha (T180C) chain

<400> 65
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Pro Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu
        115                 120                 125
Lys Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
    130                 135                 140
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
145                 150                 155                 160
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
                165                 170                 175
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
            180                 185                 190
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
        195                 200                 205
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
    210                 215                 220
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
225                 230                 235                 240
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
                245                 250                 255
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
            260                 265                 270
Ser


<210> 66
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 beta chain variable domain

<400> 66
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ile Arg Asp Ser Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr
        115                 120                 125
Arg Leu Ser Ile Leu Glu
    130

<210> 67
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 beta chain

<400> 67
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ile Arg Asp Ser Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr
        115                 120                 125
Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Phe
305                 310

<210> 68
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 beta (S190C) chain

<400> 68
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ile Arg Asp Ser Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr
        115                 120                 125
Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 69
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 beta (S190C)-P2A-WT372 alpha (T180C)

<400> 69
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ile Arg Asp Ser Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr
        115                 120                 125
Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ser Leu
                325                 330                 335
Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser
            340                 345                 350
Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu
        355                 360                 365
Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln
    370                 375                 380
Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile
385                 390                 395                 400
Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala
                405                 410                 415
Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser
            420                 425                 430
Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Pro Thr Ser Gly
        435                 440                 445
Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu Ala
    450                 455                 460
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 70
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain variable domain

<400> 70
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Gly Ala Arg Gly Gly Thr Ser Tyr Gly Lys
        115                 120                 125
Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn
    130                 135                 140

<210> 71
<211> 282
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain

<400> 71
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Gly Ala Arg Gly Gly Thr Ser Tyr Gly Lys
        115                 120                 125
Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln
    130                 135                 140
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
145                 150                 155                 160
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser
                165                 170                 175
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp
            180                 185                 190
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn
        195                 200                 205
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro
    210                 215                 220
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu
225                 230                 235                 240
Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu
                245                 250                 255
Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn
            260                 265                 270
Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        275                 280

<210> 72
<211> 282
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 alpha (T189C) chain

<400> 72
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro
 1               5                  10                  15
Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln
            20                  25                  30
Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn
        35                  40                  45
Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys
    50                  55                  60
Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys
65                  70                  75                  80
Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala
                85                  90                  95
Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala
            100                 105                 110
Val Tyr Phe Cys Ala Ala Gly Ala Arg Gly Gly Thr Ser Tyr Gly Lys
        115                 120                 125
Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln
    130                 135                 140
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
145                 150                 155                 160
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser
                165                 170                 175
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp
            180                 185                 190
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn
        195                 200                 205
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro
    210                 215                 220
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu
225                 230                 235                 240
Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu
                245                 250                 255
Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn
            260                 265                 270
Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        275                 280

<210> 73
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 beta chain variable domain

<400> 73
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ala Gln Gly Ala Tyr Gly Asn Gln Pro Gln His Phe Gly Asp Gly
        115                 120                 125
Thr Arg Leu Ser Ile Leu Glu
    130                 135

<210> 74
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 beta chain

<400> 74
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ala Gln Gly Ala Tyr Gly Asn Gln Pro Gln His Phe Gly Asp Gly
        115                 120                 125
Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Phe
305                 310

<210> 75
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 beta (S191C) chain

<400> 75
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ala Gln Gly Ala Tyr Gly Asn Gln Pro Gln His Phe Gly Asp Gly
        115                 120                 125
Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 76
<211> 615
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 beta (S191C)-P2A-WT373 alpha (T189C)

<400> 76
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Ala Gln Gly Ala Tyr Gly Asn Gln Pro Gln His Phe Gly Asp Gly
        115                 120                 125
Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu
305                 310                 315                 320
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Met
                325                 330                 335
Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro Asp Trp Val
            340                 345                 350
Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln Asn Ser Pro
        355                 360                 365
Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn Cys Asp Tyr
    370                 375                 380
Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys Tyr Pro Ala
385                 390                 395                 400
Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys Asp Lys Asn
                405                 410                 415
Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala Lys His Leu
            420                 425                 430
Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe
        435                 440                 445
Cys Ala Ala Gly Ala Arg Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe
    450                 455                 460
Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp
465                 470                 475                 480
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val
                485                 490                 495
Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys
            500                 505                 510
Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser
        515                 520                 525
Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp
    530                 535                 540
Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr
545                 550                 555                 560
Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys
                565                 570                 575
Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile
            580                 585                 590
Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met
        595                 600                 605
Thr Leu Arg Leu Trp Ser Ser
    610                 615

<210> 77
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain variable domain

<400> 77
Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln
 1               5                  10                  15
Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln
            20                  25                  30
Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser
        35                  40                  45
Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu
    50                  55                  60
Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr
65                  70                  75                  80
Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala
                85                  90                  95
Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Arg Thr Ser
            100                 105                 110
Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser Leu Ser Val Ile Pro
        115                 120                 125
Asn


<210> 78
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain

<400> 78
Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln
 1               5                  10                  15
Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln
            20                  25                  30
Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser
        35                  40                  45
Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu
    50                  55                  60
Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr
65                  70                  75                  80
Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala
                85                  90                  95
Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Arg Thr Ser
            100                 105                 110
Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser Leu Ser Val Ile Pro
        115                 120                 125
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
    130                 135                 140
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
145                 150                 155                 160
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr
                165                 170                 175
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
            180                 185                 190
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
        195                 200                 205
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
    210                 215                 220
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
225                 230                 235                 240
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
                245                 250                 255
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265

<210> 79
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 alpha (T176C) chain

<400> 79
Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln
 1               5                  10                  15
Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln
            20                  25                  30
Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser
        35                  40                  45
Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu
    50                  55                  60
Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr
65                  70                  75                  80
Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala
                85                  90                  95
Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Arg Thr Ser
            100                 105                 110
Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser Leu Ser Val Ile Pro
        115                 120                 125
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
    130                 135                 140
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
145                 150                 155                 160
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
                165                 170                 175
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
            180                 185                 190
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
        195                 200                 205
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
    210                 215                 220
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
225                 230                 235                 240
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
                245                 250                 255
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265

<210> 80
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 beta chain variable domain

<400> 80
Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr
 1               5                  10                  15
Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr
            20                  25                  30
Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His
        35                  40                  45
Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser
65                  70                  75                  80
Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser
                85                  90                  95
Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr
            100                 105                 110
Ser Ala Gly Thr Val Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu
    130

<210> 81
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 beta chain

<400> 81
Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr
 1               5                  10                  15
Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr
            20                  25                  30
Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His
        35                  40                  45
Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser
65                  70                  75                  80
Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser
                85                  90                  95
Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr
            100                 105                 110
Ser Ala Gly Thr Val Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe
305

<210> 82
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 beta (S189C) chain

<400> 82
Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr
 1               5                  10                  15
Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr
            20                  25                  30
Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His
        35                  40                  45
Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser
65                  70                  75                  80
Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser
                85                  90                  95
Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr
            100                 105                 110
Ser Ala Gly Thr Val Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 83
<211> 600
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 beta (S189C)-P2A-WT376 alpha (T176C)

<400> 83
Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr
 1               5                  10                  15
Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr
            20                  25                  30
Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His
        35                  40                  45
Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser
65                  70                  75                  80
Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser
                85                  90                  95
Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr
            100                 105                 110
Ser Ala Gly Thr Val Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Ile Thr
                325                 330                 335
Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln Val Asn Gly Gln Gln
            340                 345                 350
Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu Asp Phe
        355                 360                 365
Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln Trp Tyr
    370                 375                 380
Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu Val Lys
385                 390                 395                 400
Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe Gly Glu
                405                 410                 415
Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr Thr Asp
            420                 425                 430
Val Gly Thr Tyr Phe Cys Ala Gly Arg Thr Ser Tyr Asp Lys Val Ile
        435                 440                 445
Phe Gly Pro Gly Thr Ser Leu Ser Val Ile Pro Asn Ile Gln Asn Pro
    450                 455                 460
Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser
465                 470                 475                 480
Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser
                485                 490                 495
Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg
            500                 505                 510
Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser
        515                 520                 525
Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp
    530                 535                 540
Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu
545                 550                 555                 560
Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val
                565                 570                 575
Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu
            580                 585                 590
Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 84
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain variable domain

<400> 84
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu
        115                 120                 125
Ser Val Ile Ala Asn
    130

<210> 85
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain

<400> 85
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu
        115                 120                 125
Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
    130                 135                 140
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
145                 150                 155                 160
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
                165                 170                 175
Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
            180                 185                 190
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
        195                 200                 205
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
    210                 215                 220
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
225                 230                 235                 240
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
                245                 250                 255
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
            260                 265                 270
Ser


<210> 86
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 alpha (T180C) chain

<400> 86
Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu
 1               5                  10                  15
Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe
            20                  25                  30
Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu
    50                  55                  60
Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn
                85                  90                  95
Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys
            100                 105                 110
Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu
        115                 120                 125
Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
    130                 135                 140
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
145                 150                 155                 160
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
                165                 170                 175
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
            180                 185                 190
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
        195                 200                 205
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
    210                 215                 220
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
225                 230                 235                 240
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
                245                 250                 255
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
            260                 265                 270
Ser


<210> 87
<211> 143
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 beta chain variable domain

<400> 87
Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu
 1               5                  10                  15
Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly
            20                  25                  30
Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala
        35                  40                  45
Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr
    50                  55                  60
Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu
65                  70                  75                  80
Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln
                85                  90                  95
Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu
            100                 105                 110
Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu
        115                 120                 125
Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu
    130                 135                 140

<210> 88
<211> 319
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 beta chain

<400> 88
Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu
 1               5                  10                  15
Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly
            20                  25                  30
Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala
        35                  40                  45
Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr
    50                  55                  60
Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu
65                  70                  75                  80
Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln
                85                  90                  95
Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu
            100                 105                 110
Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu
        115                 120                 125
Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp
    130                 135                 140
Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu
145                 150                 155                 160
Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr
                165                 170                 175
Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys
            180                 185                 190
Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln
        195                 200                 205
Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val
    210                 215                 220
Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val
225                 230                 235                 240
Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala
                245                 250                 255
Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp
            260                 265                 270
Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr
        275                 280                 285
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu
    290                 295                 300
Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
305                 310                 315

<210> 89
<211> 321
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 beta (S199C) chain

<400> 89
Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu
 1               5                  10                  15
Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly
            20                  25                  30
Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala
        35                  40                  45
Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr
    50                  55                  60
Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu
65                  70                  75                  80
Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln
                85                  90                  95
Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu
            100                 105                 110
Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu
        115                 120                 125
Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp
    130                 135                 140
Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu
145                 150                 155                 160
Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr
                165                 170                 175
Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys
            180                 185                 190
Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln
        195                 200                 205
Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val
    210                 215                 220
Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val
225                 230                 235                 240
Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala
                245                 250                 255
Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp
            260                 265                 270
Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr
        275                 280                 285
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu
    290                 295                 300
Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg
305                 310                 315                 320
Gly


<210> 90
<211> 614
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 beta (S199C)-P2A-WT377 alpha (T180C)

<400> 90
Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu
 1               5                  10                  15
Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly
            20                  25                  30
Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala
        35                  40                  45
Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr
    50                  55                  60
Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu
65                  70                  75                  80
Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln
                85                  90                  95
Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu
            100                 105                 110
Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu
        115                 120                 125
Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp
    130                 135                 140
Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu
145                 150                 155                 160
Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr
                165                 170                 175
Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys
            180                 185                 190
Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln
        195                 200                 205
Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val
    210                 215                 220
Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val
225                 230                 235                 240
Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala
                245                 250                 255
Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp
            260                 265                 270
Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr
        275                 280                 285
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu
    290                 295                 300
Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Gly
305                 310                 315                 320
Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu
                325                 330                 335
Glu Asn Pro Gly Pro Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr
            340                 345                 350
Ala Ser Leu Trp Leu Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr
        355                 360                 365
Gln Pro Gly Met Phe Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys
    370                 375                 380
Thr Tyr Asp Thr Ser Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln
385                 390                 395                 400
Pro Ser Ser Gly Glu Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp
                405                 410                 415
Gln Gln Asn Ala Thr Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala
            420                 425                 430
Arg Lys Ser Ala Asn Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser
        435                 440                 445
Ala Met Tyr Phe Cys Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly
    450                 455                 460
Lys Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro
465                 470                 475                 480
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
                485                 490                 495
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
            500                 505                 510
Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met
        515                 520                 525
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
    530                 535                 540
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
545                 550                 555                 560
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
                565                 570                 575
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
            580                 585                 590
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
        595                 600                 605
Leu Arg Leu Trp Ser Ser
    610

<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201 alpha CDR3

<400> 91
Cys Leu Leu Arg Asn His Asp Lys Leu Ile Phe
 1               5                  10

<210> 92
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301 alpha CDR3

<400> 92
Cys Ala Val Gly Asn Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe
 1               5                  10                  15

<210> 93
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 alpha CDR3

<400> 93
Cys Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe
 1               5                  10

<210> 94
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 alpha CDR3

<400> 94
Cys Ala Val Arg Asp Ile Arg Tyr Tyr Gly Gly Ser Gln Gly Asn Leu
 1               5                  10                  15
Ile Phe


<210> 95
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 alpha CDR3

<400> 95
Cys Ala Ile Tyr Gly Trp Gly Gly Gly Ala Thr Asn Lys Leu Ile Phe
 1               5                  10                  15

<210> 96
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 alpha CDR3

<400> 96
Cys Ala Val Gly Gly Ser Gly Gly Tyr Gln Lys Val Thr Phe
 1               5                  10

<210> 97
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 alpha CDR3

<400> 97
Cys Val Val Lys Pro Asp Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe
 1               5                  10                  15

<210> 98
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 alpha CDR3

<400> 98
Cys Ala Met Arg Ala Arg Glu Glu Thr Ser Gly Ser Arg Leu Thr Phe
 1               5                  10                  15

<210> 99
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 alpha CDR3

<400> 99
Cys Ala Val Pro Thr Ser Gly Thr Tyr Lys Tyr Ile Phe
 1               5                  10

<210> 100
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 alpha CDR3

<400> 100
Cys Ala Ala Gly Ala Arg Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe
 1               5                  10                  15

<210> 101
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 alpha CDR3

<400> 101
Cys Ala Gly Arg Thr Ser Tyr Asp Lys Val Ile Phe
 1               5                  10

<210> 102
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 alpha CDR3

<400> 102
Cys Ala Ile Ser Gly Asn Thr Pro Leu Val Phe
 1               5                  10

<210> 103
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME201 beta CDR3

<400> 103
Cys Ala Ser Ser Gln Asp Ser Tyr Asn Glu Gln Phe Phe
 1               5                  10

<210> 104
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> ME5301 beta CDR3

<400> 104
Cys Ala Ser Ser Leu Ala Gly Gly Tyr Gly Asp Thr Gln Tyr Phe
 1               5                  10                  15

<210> 105
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT374 beta CDR3

<400> 105
Cys Ala Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe
 1               5                  10

<210> 106
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT375 beta CDR3

<400> 106
Cys Ala Ser Ser Pro Gly Pro Ser Asn Asn Glu Gln Phe Phe
 1               5                  10

<210> 107
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT378 beta CDR3

<400> 107
Cys Ala Ser Ser Leu Tyr Gly Gly Ser Ser Tyr Glu Gln Tyr Phe
 1               5                  10                  15

<210> 108
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT379 beta CDR3

<400> 108
Cys Ala Ser Ser Gly Arg Ala Gly Val Gly Glu Leu Phe Phe
 1               5                  10

<210> 109
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT3710 beta CDR3

<400> 109
Cys Ala Ser Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe
 1               5                  10                  15

<210> 110
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT371 beta CDR3

<400> 110
Cys Ala Ser Ser Gln Asp Gly Arg Ser Arg Pro Gln His Phe
 1               5                  10

<210> 111
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT372 beta CDR3

<400> 111
Cys Ala Ser Ser Ile Arg Asp Ser Ser Asn Gln Pro Gln His Phe
 1               5                  10                  15

<210> 112
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT373 beta CDR3

<400> 112
Cys Ala Ser Ser Ala Gln Gly Ala Tyr Gly Asn Gln Pro Gln His Phe
 1               5                  10                  15

<210> 113
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT376 beta CDR3

<400> 113
Cys Ala Thr Ser Ala Gly Thr Val Gly Asn Thr Ile Tyr Phe
 1               5                  10

<210> 114
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT377 beta CDR3

<400> 114
Cys Ala Ser Ser Leu Arg Gly Gly Leu Glu Lys Leu Phe Phe
 1               5                  10

<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mesothelin (20-28) Peptide Antigen

<400> 115
Ser Leu Leu Phe Leu Leu Phe Ser Leu
 1               5

<210> 116
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mesothelin (530-538) Peptide Antigen

<400> 116
Val Leu Pro Leu Thr Val Ala Glu Val
 1               5

<210> 117
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> WT-1 Peptide Antigen

<400> 117
Val Leu Asp Phe Ala Pro Pro Gly Ala
 1               5

<210> 118
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide

<400> 118
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 119
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thoseaasigna virus 2A (T2A) peptide

<400> 119
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 120
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Equine rhinitis A virus (ERAV) 2A (E2A) peptide

<400> 120
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15
Val Glu Ser Asn Pro Gly Pro
            20

<210> 121
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Foot-and-Mouth disease virus 2A (F2A) peptide

<400> 121
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 122
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain variable domain WT

<400> 122
atgaactcct ctctggactt tctaattctg atcttaatgt ttggaggaac cagcagcaat      60
tcagtcaagc agacgggcca aataaccgtc tcggagggag catctgtgac tatgaactgc     120
acatacacat ccacggggta ccctaccctt ttctggtatg tggaataccc cagcaaacct     180
ctgcagcttc ttcagagaga gacaatggaa aacagcaaaa acttcggagg cggaaatatt     240
aaagacaaaa actcccccat tgtgaaatat tcagtccagg tatcagactc agccgtgtac     300
tactgtcttc tgaggaatca cgacaagctc atctttggga ctgggaccag attacaagtc     360
tttccaaat                                                             369

<210> 123
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain variable domain - Codon
      Optimized

<400> 123
atgaacagca gcctggactt cctgatcctg attctgatgt tcggcggcac cagcagcaac      60
agcgtgaagc agacaggcca gatcaccgtg tctgagggcg ccagcgtgac catgaactgc     120
acctacacca gcaccggcta ccccaccctg ttttggtacg tggaataccc cagcaagccc     180
ctccagctgc tccagcggga aaccatggaa aacagcaaga acttcggcgg aggcaacatc     240
aaggacaaga acagccccat cgtgaagtac agcgtgcagg tgtccgacag cgccgtgtac     300
tactgcctgc tgcggaacca cgacaagctg atcttcggca ccggcacccg gctccaggtg     360
ttccccaac                                                             369

<210> 124
<211> 423
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain constant domain WT

<400> 124
atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct      60
gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat     120
gtgtatatca cagacaaaac tgtgctagac atgaggtcta tggacttcaa gagcaacagt     180
gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt     240
attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag     300
aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga     360
atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc     420
tga                                                                   423

<210> 125
<211> 423
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain constant domain -
      Codon-Optimized

<400> 125
atccagaacc ccgaccccgc agtgtaccag ctgcgggaca gcaagagcag cgacaagagc      60
gtgtgcctgt tcaccgactt cgacagccag accaacgtgt cccagagcaa ggacagcgac     120
gtgtacatca ccgataagac cgtgctggac atgcggagca tggacttcaa gagcaacagc     180
gccgtggcct ggtccaacaa gagcgacttc gcctgcgcca acgccttcaa caacagcatt     240
atccccgagg acacattctt cccaagcccc gagagcagct gcgacgtgaa gctggtggaa     300
aagagcttcg agacagacac caacctgaac ttccagaacc tcagcgtgat cggcttccgg     360
atcctgctgc tgaaggtggc cggcttcaac ctgctgatga ccctgcggct gtggtccagc     420
tga                                                                   423

<210> 126
<211> 423
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain constant domain - Cys Modified

<400> 126
atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct      60
gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat     120
gtgtatatca cagacaaatg cgtgctagac atgaggtcta tggacttcaa gagcaacagt     180
gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt     240
attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag     300
aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga     360
atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc     420
tga                                                                   423

<210> 127
<211> 423
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain constant domain -
      Codon-Optimized, Cys Modified

<400> 127
atccagaacc ccgaccccgc agtgtaccag ctgcgggaca gcaagagcag cgacaagagc      60
gtgtgcctgt tcaccgactt cgacagccag accaacgtgt cccagagcaa ggacagcgac     120
gtgtacatca ccgataagtg cgtgctggac atgcggagca tggacttcaa gagcaacagc     180
gccgtggcct ggtccaacaa gagcgacttc gcctgcgcca acgccttcaa caacagcatt     240
atccccgagg acacattctt cccaagcccc gagagcagct gcgacgtgaa gctggtggaa     300
aagagcttcg agacagacac caacctgaac ttccagaacc tcagcgtgat cggcttccgg     360
atcctgctgc tgaaggtggc cggcttcaac ctgctgatga ccctgcggct gtggtccagc     420
tga                                                                   423

<210> 128
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha chain WT

<400> 128
atgaactcct ctctggactt tctaattctg atcttaatgt ttggaggaac cagcagcaat      60
tcagtcaagc agacgggcca aataaccgtc tcggagggag catctgtgac tatgaactgc     120
acatacacat ccacggggta ccctaccctt ttctggtatg tggaataccc cagcaaacct     180
ctgcagcttc ttcagagaga gacaatggaa aacagcaaaa acttcggagg cggaaatatt     240
aaagacaaaa actcccccat tgtgaaatat tcagtccagg tatcagactc agccgtgtac     300
tactgtcttc tgaggaatca cgacaagctc atctttggga ctgggaccag attacaagtc     360
tttccaaata tccagaaccc tgaccctgcc gtgtaccagc tgagagactc taaatccagt     420
gacaagtctg tctgcctatt caccgatttt gattctcaaa caaatgtgtc acaaagtaag     480
gattctgatg tgtatatcac agacaaaact gtgctagaca tgaggtctat ggacttcaag     540
agcaacagtg ctgtggcctg gagcaacaaa tctgactttg catgtgcaaa cgccttcaac     600
aacagcatta ttccagaaga caccttcttc cccagcccag aaagttcctg tgatgtcaag     660
ctggtcgaga aaagctttga aacagatacg aacctaaact ttcaaaacct gtcagtgatt     720
gggttccgaa tcctcctcct gaaagtggcc gggtttaatc tgctcatgac gctgcggctg     780
tggtccagct ga                                                         792

<210> 129
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 alpha  chain - Codon-Optimized, Cys Modified

<400> 129
atgaacagca gcctggactt cctgatcctg attctgatgt tcggcggcac cagcagcaac      60
agcgtgaagc agacaggcca gatcaccgtg tctgagggcg ccagcgtgac catgaactgc     120
acctacacca gcaccggcta ccccaccctg ttttggtacg tggaataccc cagcaagccc     180
ctccagctgc tccagcggga aaccatggaa aacagcaaga acttcggcgg aggcaacatc     240
aaggacaaga acagccccat cgtgaagtac agcgtgcagg tgtccgacag cgccgtgtac     300
tactgcctgc tgcggaacca cgacaagctg atcttcggca ccggcacccg gctccaggtg     360
ttccccaaca tccagaaccc cgaccccgca gtgtaccagc tgcgggacag caagagcagc     420
gacaagagcg tgtgcctgtt caccgacttc gacagccaga ccaacgtgtc ccagagcaag     480
gacagcgacg tgtacatcac cgataagtgc gtgctggaca tgcggagcat ggacttcaag     540
agcaacagcg ccgtggcctg gtccaacaag agcgacttcg cctgcgccaa cgccttcaac     600
aacagcatta tccccgagga cacattcttc ccaagccccg agagcagctg cgacgtgaag     660
ctggtggaaa agagcttcga gacagacacc aacctgaact tccagaacct cagcgtgatc     720
ggcttccgga tcctgctgct gaaggtggcc ggcttcaacc tgctgatgac cctgcggctg     780
tggtccagct ga                                                         792

<210> 130
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain variable domain WT

<400> 130
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagcc aagactcgta caatgagcag     360
ttcttcgggc cagggacacg gctcaccgtg ctagag                               396

<210> 131
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain variable domain - Codon Optimized

<400> 131
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gccagcagcc aggacagcta caacgagcag     360
ttcttcggcc ctggcacccg gctgaccgtg ctggaa                               396

<210> 132
<211> 534
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain constant domain WT

<400> 132
gacctgaaaa acgtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc      60
tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttctaccc cgaccacgtg     120
gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac agacccgcag     180
cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg     240
gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac     300
gggctctcgg agaatgacga gtggacccag gatagggcca aacctgtcac ccagatcgtc     360
agcgccgagg cctggggtag agcagactgt ggcttcacct ccgagtctta ccagcaaggg     420
gtcctgtctg ccaccatcct ctatgagatc ttgctaggga aggccacctt gtatgccgtg     480
ctggtcagtg ccctcgtgct gatggccatg gtcaagagaa aggattccag aggc           534

<210> 133
<211> 534
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain constant domain - Cys Modified

<400> 133
gacctgaaaa acgtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc      60
tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttctaccc cgaccacgtg     120
gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtctgcac agacccgcag     180
cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg     240
gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac     300
gggctctcgg agaatgacga gtggacccag gatagggcca aacctgtcac ccagatcgtc     360
agcgccgagg cctggggtag agcagactgt ggcttcacct ccgagtctta ccagcaaggg     420
gtcctgtctg ccaccatcct ctatgagatc ttgctaggga aggccacctt gtatgccgtg     480
ctggtcagtg ccctcgtgct gatggccatg gtcaagagaa aggattccag aggc           534

<210> 134
<211> 534
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain constant domain - Codon Optimized

<400> 134
gatctgaaga acgtgttccc cccagaggtg gccgtgttcg agcctagcga ggccgagatc      60
agccacaccc agaaagccac cctcgtgtgc ctggccaccg gcttttaccc cgaccacgtg     120
gaactgtctt ggtgggtcaa cggcaaagag gtgcacagcg gcgtcagcac cgacccccag     180
cccctgaaag agcagcccgc cctgaacgac agccggtact gtctgagcag cagactgaga     240
gtgtccgcca ccttctggca gaacccccgg aaccacttca gatgccaggt gcagttctac     300
ggcctgagcg agaacgacga gtggacccag gaccgggcca agcccgtgac ccagatcgtg     360
tctgctgagg cctggggcag agccgattgc ggcttcacca gcgagagcta ccagcagggc     420
gtgctgagcg ccaccatcct gtacgagatc ctgctgggca aggccaccct gtacgccgtg     480
ctggtgtccg ccctggtgct gatggccatg gtcaagcgga aggacagccg gggc           534

<210> 135
<211> 534
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain constant domain -
      Codon-Optimized, Cys Modified

<400> 135
gatctgaaga acgtgttccc cccagaggtg gccgtgttcg agcctagcga ggccgagatc      60
agccacaccc agaaagccac cctcgtgtgc ctggccaccg gcttttaccc cgaccacgtg     120
gaactgtctt ggtgggtcaa cggcaaagag gtgcacagcg gcgtctgcac cgacccccag     180
cccctgaaag agcagcccgc cctgaacgac agccggtact gtctgagcag cagactgaga     240
gtgtccgcca ccttctggca gaacccccgg aaccacttca gatgccaggt gcagttctac     300
ggcctgagcg agaacgacga gtggacccag gaccgggcca agcccgtgac ccagatcgtg     360
tctgctgagg cctggggcag agccgattgc ggcttcacca gcgagagcta ccagcagggc     420
gtgctgagcg ccaccatcct gtacgagatc ctgctgggca aggccaccct gtacgccgtg     480
ctggtgtccg ccctggtgct gatggccatg gtcaagcgga aggacagccg gggc           534

<210> 136
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain WT

<400> 136
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagcc aagactcgta caatgagcag     360
ttcttcgggc cagggacacg gctcaccgtg ctagaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc                                      930

<210> 137
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta chain - Codon-Optimized, Cys Modified

<400> 137
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gccagcagcc aggacagcta caacgagcag     360
ttcttcggcc ctggcacccg gctgaccgtg ctggaagatc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc                                      930

<210> 138
<211> 1788
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta-P2A-ME201 alpha Construct - WT

<400> 138
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagcc aagactcgta caatgagcag     360
ttcttcgggc cagggacacg gctcaccgtg ctagaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatga actcctctct ggactttcta    1020
attctgatct taatgtttgg aggaaccagc agcaattcag tcaagcagac gggccaaata    1080
accgtctcgg agggagcatc tgtgactatg aactgcacat acacatccac ggggtaccct    1140
acccttttct ggtatgtgga ataccccagc aaacctctgc agcttcttca gagagagaca    1200
atggaaaaca gcaaaaactt cggaggcgga aatattaaag acaaaaactc ccccattgtg    1260
aaatattcag tccaggtatc agactcagcc gtgtactact gtcttctgag gaatcacgac    1320
aagctcatct ttgggactgg gaccagatta caagtctttc caaatatcca gaaccctgac    1380
cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc    1440
gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac    1500
aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc    1560
aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc    1620
ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca    1680
gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa    1740
gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                 1788

<210> 139
<211> 1788
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME201 beta-P2A-ME201 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 139
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gccagcagcc aggacagcta caacgagcag     360
ttcttcggcc ctggcacccg gctgaccgtg ctggaagatc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatga acagcagcct ggacttcctg    1020
atcctgattc tgatgttcgg cggcaccagc agcaacagcg tgaagcagac aggccagatc    1080
accgtgtctg agggcgccag cgtgaccatg aactgcacct acaccagcac cggctacccc    1140
accctgtttt ggtacgtgga ataccccagc aagcccctcc agctgctcca gcgggaaacc    1200
atggaaaaca gcaagaactt cggcggaggc aacatcaagg acaagaacag ccccatcgtg    1260
aagtacagcg tgcaggtgtc cgacagcgcc gtgtactact gcctgctgcg gaaccacgac    1320
aagctgatct tcggcaccgg cacccggctc caggtgttcc ccaacatcca gaaccccgac    1380
cccgcagtgt accagctgcg ggacagcaag agcagcgaca agagcgtgtg cctgttcacc    1440
gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta catcaccgat    1500
aagtgcgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc    1560
aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcattatccc cgaggacaca    1620
ttcttcccaa gccccgagag cagctgcgac gtgaagctgg tggaaaagag cttcgagaca    1680
gacaccaacc tgaacttcca gaacctcagc gtgatcggct tccggatcct gctgctgaag    1740
gtggccggct tcaacctgct gatgaccctg cggctgtggt ccagctga                 1788

<210> 140
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 alpha chain variable domain WT

<400> 140
atgaagaagc tactagcaat gattctgtgg cttcaactag accggttaag tggagagctg      60
aaagtggaac aaaaccctct gttcctgagc atgcaggagg gaaaaaacta taccatctac     120
tgcaattatt caaccacttc agacagactg tattggtaca ggcaggatcc tgggaaaagt     180
ctggaatctc tgtttgtgtt gctatcaaat ggagcagtga agcaggaggg acgattaatg     240
gcctcacttg ataccaaagc ccgtctcagc accctccaca tcacagctgc cgtgcatgac     300
ctctctgcca cctacttctg tgccgtgggc aattatggag gaagccaagg aaatctcatc     360
tttggaaaag gcactaaact ctctgttaaa ccaaat                               396

<210> 141
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 alpha chain variable domain - Codon
      Optimized

<400> 141
atgaagaaac tgctggccat gatcctgtgg ctgcagctgg acagactgag cggcgagctg      60
aaggtggaac agaaccccct gttcctgagc atgcaggaag gcaagaacta caccatctac     120
tgcaactaca gcaccaccag cgaccggctg tactggtaca gacaggaccc cggcaagagc     180
ctggaaagcc tgttcgtgct gctgagcaat ggcgccgtga agcaggaagg acggctgatg     240
gccagcctgg acaccaaggc cagactgtcc accctgcaca tcacagccgc cgtgcacgat     300
ctgagcgcca cctacttttg cgccgtgggc aattacggcg gcagccaggg caatctgatc     360
ttcggcaagg gcaccaagct gagcgtgaag cccaac                               396

<210> 142
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 alhpa chain WT

<400> 142
atgaagaagc tactagcaat gattctgtgg cttcaactag accggttaag tggagagctg      60
aaagtggaac aaaaccctct gttcctgagc atgcaggagg gaaaaaacta taccatctac     120
tgcaattatt caaccacttc agacagactg tattggtaca ggcaggatcc tgggaaaagt     180
ctggaatctc tgtttgtgtt gctatcaaat ggagcagtga agcaggaggg acgattaatg     240
gcctcacttg ataccaaagc ccgtctcagc accctccaca tcacagctgc cgtgcatgac     300
ctctctgcca cctacttctg tgccgtgggc aattatggag gaagccaagg aaatctcatc     360
tttggaaaag gcactaaact ctctgttaaa ccaaatatcc agaaccctga ccctgccgtg     420
taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     480
tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     540
ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     600
gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     660
agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac     720
ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg     780
tttaatctgc tcatgacgct gcggctgtgg tccagctga                            819

<210> 143
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301alpha chain - Codon-Optimized, Cys Modified

<400> 143
atgaagaaac tgctggccat gatcctgtgg ctgcagctgg acagactgag cggcgagctg      60
aaggtggaac agaaccccct gttcctgagc atgcaggaag gcaagaacta caccatctac     120
tgcaactaca gcaccaccag cgaccggctg tactggtaca gacaggaccc cggcaagagc     180
ctggaaagcc tgttcgtgct gctgagcaat ggcgccgtga agcaggaagg acggctgatg     240
gccagcctgg acaccaaggc cagactgtcc accctgcaca tcacagccgc cgtgcacgat     300
ctgagcgcca cctacttttg cgccgtgggc aattacggcg gcagccaggg caatctgatc     360
ttcggcaagg gcaccaagct gagcgtgaag cccaacatcc agaaccccga ccccgcagtg     420
taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac     480
agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg     540
ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc     600
gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca     660
agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac     720
ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc     780
ttcaacctgc tgatgaccct gcggctgtgg tccagctga                            819

<210> 144
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta chain variable domain WT

<400> 144
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagct tggcgggagg atacggagat     360
acgcagtatt ttggcccagg cacccggctg acagtgctcg ag                        402

<210> 145
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta chain variable domain - Codon
      Optimized

<400> 145
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gcctcttctc tggctggcgg ctacggcgac     360
acccagtatt ttggccctgg caccagactg accgtgctgg aa                        402

<210> 146
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta chain WT

<400> 146
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagct tggcgggagg atacggagat     360
acgcagtatt ttggcccagg cacccggctg acagtgctcg aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggc                               936

<210> 147
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta chain - Codon-Optimized, Cys Modified

<400> 147
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gcctcttctc tggctggcgg ctacggcgac     360
acccagtatt ttggccctgg caccagactg accgtgctgg aagatctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggc                               936

<210> 148
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta-P2A-ME5301 alpha Construct - WT

<400> 148
atgggccctg ggctcctctg ctgggtgctg ctttgtctcc tgggagcagg ctcagtggag      60
actggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctt ctcagtctgg gcacaacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatagg gaggaagaga atggcagagg aaacttccct     240
cctagattct caggtctcca gttccctaat tatagctctg agctgaatgt gaacgccttg     300
gagctggacg actcggccct gtatctctgt gccagcagct tggcgggagg atacggagat     360
acgcagtatt ttggcccagg cacccggctg acagtgctcg aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgaagaa gctactagca    1020
atgattctgt ggcttcaact agaccggtta agtggagagc tgaaagtgga acaaaaccct    1080
ctgttcctga gcatgcagga gggaaaaaac tataccatct actgcaatta ttcaaccact    1140
tcagacagac tgtattggta caggcaggat cctgggaaaa gtctggaatc tctgtttgtg    1200
ttgctatcaa atggagcagt gaagcaggag ggacgattaa tggcctcact tgataccaaa    1260
gcccgtctca gcaccctcca catcacagct gccgtgcatg acctctctgc cacctacttc    1320
tgtgccgtgg gcaattatgg aggaagccaa ggaaatctca tctttggaaa aggcactaaa    1380
ctctctgtta aaccaaatat ccagaaccct gaccctgccg tgtaccagct gagagactct    1440
aaatccagtg acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca    1500
caaagtaagg attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg    1560
gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac    1620
gccttcaaca acagcattat tccagaagac accttcttcc ccagcccaga aagttcctgt    1680
gatgtcaagc tggtcgagaa aagctttgaa acagatacga acctaaactt tcaaaacctg    1740
tcagtgattg ggttccgaat cctcctcctg aaagtggccg ggtttaatct gctcatgacg    1800
ctgcggctgt ggtccagctg a                                              1821

<210> 149
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> ME5301 beta-P2A-ME5301 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 149
atgggacctg gcctgctgtg ttgggtgctg ctgtgtctgc tgggagccgg cagtgtggaa      60
accggcgtga cacagagccc cacccacctg atcaagacca gaggccagca agtgaccctg     120
cggtgcagct ctcagagcgg ccacaatacc gtgtcctggt atcagcaggc cctgggccag     180
ggaccccagt tcatcttcca gtactacaga gaggaagaga acggcagagg caacttccca     240
ccccggttta gcggcctgca gttccccaac tacagctccg agctgaacgt gaacgccctg     300
gaactggacg acagcgccct gtacctgtgt gcctcttctc tggctggcgg ctacggcgac     360
acccagtatt ttggccctgg caccagactg accgtgctgg aagatctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgaagaa actgctggcc    1020
atgatcctgt ggctgcagct ggacagactg agcggcgagc tgaaggtgga acagaacccc    1080
ctgttcctga gcatgcagga aggcaagaac tacaccatct actgcaacta cagcaccacc    1140
agcgaccggc tgtactggta cagacaggac cccggcaaga gcctggaaag cctgttcgtg    1200
ctgctgagca atggcgccgt gaagcaggaa ggacggctga tggccagcct ggacaccaag    1260
gccagactgt ccaccctgca catcacagcc gccgtgcacg atctgagcgc cacctacttt    1320
tgcgccgtgg gcaattacgg cggcagccag ggcaatctga tcttcggcaa gggcaccaag    1380
ctgagcgtga agcccaacat ccagaacccc gaccccgcag tgtaccagct gcgggacagc    1440
aagagcagcg acaagagcgt gtgcctgttc accgacttcg acagccagac caacgtgtcc    1500
cagagcaagg acagcgacgt gtacatcacc gataagtgcg tgctggacat gcggagcatg    1560
gacttcaaga gcaacagcgc cgtggcctgg tccaacaaga gcgacttcgc ctgcgccaac    1620
gccttcaaca acagcattat ccccgaggac acattcttcc caagccccga gagcagctgc    1680
gacgtgaagc tggtggaaaa gagcttcgag acagacacca acctgaactt ccagaacctc    1740
agcgtgatcg gcttccggat cctgctgctg aaggtggccg gcttcaacct gctgatgacc    1800
ctgcggctgt ggtccagctg a                                              1821

<210> 150
<211> 411
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain variable domain WT

<400> 150
atggccatgc tcctgggggc atcagtgctg attctgtggc ttcagccaga ctgggtaaac      60
agtcaacaga agaatgatga ccagcaagtt aagcaaaatt caccatccct gagcgtccag     120
gaaggaagaa tttctattct gaactgtgac tatactaaca gcatgtttga ttatttccta     180
tggtacaaaa aataccctgc tgaaggtcct acattcctga tatctataag ttccattaag     240
gataaaaatg aagatggaag attcactgtc ttcttaaaca aaagtgccaa gcacctctct     300
ctgcacattg tgccctccca gcctggagac tctgcagtgt acttctgtgc agcaagaggc     360
caaggaaatc tcatctttgg aaaaggcact aaactctctg ttaaaccaaa t              411

<210> 151
<211> 411
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain variable domain - Codon
      Optimized

<400> 151
atggctatgc tgctgggcgc ctctgtgctg atcctgtggc tgcagcccga ctgggtcaac      60
agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcag     120
gaaggccgga tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg     180
tggtacaaga agtaccccgc cgagggcccc accttcctga tctccatcag cagcatcaag     240
gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc     300
ctgcacatcg tgcctagcca gcctggcgat agcgccgtgt acttctgtgc cgccagaggc     360
cagggcaacc tgatctttgg caagggcacc aagctgagcg tgaagcccaa c              411

<210> 152
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain WT

<400> 152
atggccatgc tcctgggggc atcagtgctg attctgtggc ttcagccaga ctgggtaaac      60
agtcaacaga agaatgatga ccagcaagtt aagcaaaatt caccatccct gagcgtccag     120
gaaggaagaa tttctattct gaactgtgac tatactaaca gcatgtttga ttatttccta     180
tggtacaaaa aataccctgc tgaaggtcct acattcctga tatctataag ttccattaag     240
gataaaaatg aagatggaag attcactgtc ttcttaaaca aaagtgccaa gcacctctct     300
ctgcacattg tgccctccca gcctggagac tctgcagtgt acttctgtgc agcaagaggc     360
caaggaaatc tcatctttgg aaaaggcact aaactctctg ttaaaccaaa tatccagaac     420
cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta     480
ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc     540
acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc     600
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa     660
gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt     720
gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc     780
ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctga           834

<210> 153
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain - Codon-Optimized, Cys Modified

<400> 153
atggctatgc tgctgggcgc ctctgtgctg atcctgtggc tgcagcccga ctgggtcaac      60
agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcag     120
gaaggccgga tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg     180
tggtacaaga agtaccccgc cgagggcccc accttcctga tctccatcag cagcatcaag     240
gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc     300
ctgcacatcg tgcctagcca gcctggcgat agcgccgtgt acttctgtgc cgccagaggc     360
cagggcaacc tgatctttgg caagggcacc aagctgagcg tgaagcccaa catccagaac     420
cccgaccccg cagtgtacca gctgcgggac agcaagagca gcgacaagag cgtgtgcctg     480
ttcaccgact tcgacagcca gaccaacgtg tcccagagca aggacagcga cgtgtacatc     540
accgataagt gcgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc     600
tggtccaaca agagcgactt cgcctgcgcc aacgccttca acaacagcat tatccccgag     660
gacacattct tcccaagccc cgagagcagc tgcgacgtga agctggtgga aaagagcttc     720
gagacagaca ccaacctgaa cttccagaac ctcagcgtga tcggcttccg gatcctgctg     780
ctgaaggtgg ccggcttcaa cctgctgatg accctgcggc tgtggtccag ctga           834

<210> 154
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 alpha chain variable domain WT

<400> 154
atgggcacca ggctcctctg ctgggcggcc ctctgtctcc tgggagcaga actcacagaa      60
gctggagttg cccagtctcc cagatataag attatagaga aaaggcagag tgtggctttt     120
tggtgcaatc ctatatctgg ccatgctacc ctttactggt accagcagat cctgggacag     180
ggcccaaagc ttctgattca gtttcagaat aacggtgtag tggatgattc acagttgcct     240
aaggatcgat tttctgcaga gaggctcaaa ggagtagact ccactctcaa gatccaacct     300
gcaaagcttg aggactcggc cgtgtatctc tgtgccagca gcttatatag gggggagcag     360
tacttcgggc cgggcaccag gctcacggtc acagag                               396

<210> 155
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 beta chain variable domain - Codon Optimized

<400> 155
atgggcacca gactgctgtg ttgggccgct ctgtgtctgc tgggagccga actgactgaa      60
gctggcgtgg cccagagccc ccggtacaag atcatcgaga agcggcagag cgtggccttc     120
tggtgcaacc ctatcagcgg acacgccacc ctgtactggt atcagcagat cctgggccag     180
ggccccaagc tgctgattca gttccagaac aacggcgtgg tggacgacag ccagctgccc     240
aaggatagat tcagcgccga gcggctgaag ggcgtggaca gcacactgaa gatccagccc     300
gccaagctgg aagatagcgc cgtgtacctg tgcgccagca gcctgtatag aggcgagcag     360
tacttcggcc ctggcacccg gctgaccgtg accgag                               396

<210> 156
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 beta chain WT

<400> 156
atgggcacca ggctcctctg ctgggcggcc ctctgtctcc tgggagcaga actcacagaa      60
gctggagttg cccagtctcc cagatataag attatagaga aaaggcagag tgtggctttt     120
tggtgcaatc ctatatctgg ccatgctacc ctttactggt accagcagat cctgggacag     180
ggcccaaagc ttctgattca gtttcagaat aacggtgtag tggatgattc acagttgcct     240
aaggatcgat tttctgcaga gaggctcaaa ggagtagact ccactctcaa gatccaacct     300
gcaaagcttg aggactcggc cgtgtatctc tgtgccagca gcttatatag gggggagcag     360
tacttcgggc cgggcaccag gctcacggtc acagaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc                                      930

<210> 157
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 beta chain - Codon-Optimized, Cys Modified

<400> 157
atgggcacca gactgctgtg ttgggccgct ctgtgtctgc tgggagccga actgactgaa      60
gctggcgtgg cccagagccc ccggtacaag atcatcgaga agcggcagag cgtggccttc     120
tggtgcaacc ctatcagcgg acacgccacc ctgtactggt atcagcagat cctgggccag     180
ggccccaagc tgctgattca gttccagaac aacggcgtgg tggacgacag ccagctgccc     240
aaggatagat tcagcgccga gcggctgaag ggcgtggaca gcacactgaa gatccagccc     300
gccaagctgg aagatagcgc cgtgtacctg tgcgccagca gcctgtatag aggcgagcag     360
tacttcggcc ctggcacccg gctgaccgtg accgaggatc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc                                      930

<210> 158
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 beta-P2A-WT374 alpha Construct - WT

<400> 158
atgggcacca ggctcctctg ctgggcggcc ctctgtctcc tgggagcaga actcacagaa      60
gctggagttg cccagtctcc cagatataag attatagaga aaaggcagag tgtggctttt     120
tggtgcaatc ctatatctgg ccatgctacc ctttactggt accagcagat cctgggacag     180
ggcccaaagc ttctgattca gtttcagaat aacggtgtag tggatgattc acagttgcct     240
aaggatcgat tttctgcaga gaggctcaaa ggagtagact ccactctcaa gatccaacct     300
gcaaagcttg aggactcggc cgtgtatctc tgtgccagca gcttatatag gggggagcag     360
tacttcgggc cgggcaccag gctcacggtc acagaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatgg ccatgctcct gggggcatca    1020
gtgctgattc tgtggcttca gccagactgg gtaaacagtc aacagaagaa tgatgaccag    1080
caagttaagc aaaattcacc atccctgagc gtccaggaag gaagaatttc tattctgaac    1140
tgtgactata ctaacagcat gtttgattat ttcctatggt acaaaaaata ccctgctgaa    1200
ggtcctacat tcctgatatc tataagttcc attaaggata aaaatgaaga tggaagattc    1260
actgtcttct taaacaaaag tgccaagcac ctctctctgc acattgtgcc ctcccagcct    1320
ggagactctg cagtgtactt ctgtgcagca agaggccaag gaaatctcat ctttggaaaa    1380
ggcactaaac tctctgttaa accaaatatc cagaaccctg accctgccgt gtaccagctg    1440
agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca    1500
aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg    1560
aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca    1620
tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa    1680
agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt    1740
caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg    1800
ctcatgacgc tgcggctgtg gtccagctga                                     1830

<210> 159
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT374 beta-P2A-WT374 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 159
atgggcacca gactgctgtg ttgggccgct ctgtgtctgc tgggagccga actgactgaa      60
gctggcgtgg cccagagccc ccggtacaag atcatcgaga agcggcagag cgtggccttc     120
tggtgcaacc ctatcagcgg acacgccacc ctgtactggt atcagcagat cctgggccag     180
ggccccaagc tgctgattca gttccagaac aacggcgtgg tggacgacag ccagctgccc     240
aaggatagat tcagcgccga gcggctgaag ggcgtggaca gcacactgaa gatccagccc     300
gccaagctgg aagatagcgc cgtgtacctg tgcgccagca gcctgtatag aggcgagcag     360
tacttcggcc ctggcacccg gctgaccgtg accgaggatc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatgg ctatgctgct gggcgcctct    1020
gtgctgatcc tgtggctgca gcccgactgg gtcaacagcc agcagaagaa cgacgaccag    1080
caagtgaagc agaacagccc cagcctgagc gtgcaggaag gccggatcag catcctgaac    1140
tgcgactaca ccaactctat gttcgactac ttcctgtggt acaagaagta ccccgccgag    1200
ggccccacct tcctgatctc catcagcagc atcaaggaca agaacgagga cggccggttc    1260
accgtgtttc tgaacaagag cgccaagcac ctgagcctgc acatcgtgcc tagccagcct    1320
ggcgatagcg ccgtgtactt ctgtgccgcc agaggccagg gcaacctgat ctttggcaag    1380
ggcaccaagc tgagcgtgaa gcccaacatc cagaaccccg accccgcagt gtaccagctg    1440
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc    1500
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg    1560
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc    1620
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag    1680
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc    1740
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg    1800
ctgatgaccc tgcggctgtg gtccagctga                                     1830

<210> 160
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain variable domain WT

<400> 160
atggcctctg cacccatctc gatgcttgcg atgctcttca cattgagtgg gctgagagct      60
cagtcagtgg ctcagccgga agatcaggtc aacgttgctg aagggaatcc tctgactgtg     120
aaatgcacct attcagtctc tggaaaccct tatctttttt ggtatgttca ataccccaac     180
cgaggcctcc agttccttct gaaatacatc acaggggata acctggttaa aggcagctat     240
ggctttgaag ctgaatttaa caagagccaa acctccttcc acctgaagaa accatctgcc     300
cttgtgagcg actccgcttt gtacttctgt gctgtgagag acattaggta ttatggagga     360
agccaaggaa atctcatctt tggaaaaggc actaaactct ctgttaaacc aaat           414

<210> 161
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain variable domain - Codon
      Optimized

<400> 161
atggccagcg cccccattag catgctggct atgctgttca ccctgagcgg cctgagagcc      60
cagtctgtgg cccagcctga ggaccaagtg aatgtggccg agggcaaccc cctgaccgtg     120
aagtgtacct acagcgtgtc cggcaacccc tacctgtttt ggtacgtgca gtaccccaac     180
cggggcctgc agttcctgct gaagtacatc accggcgaca acctcgtgaa gggcagctac     240
ggcttcgagg ccgagttcaa caagagccag accagcttcc acctgaagaa acccagcgcc     300
ctggtgtccg actccgccct gtatttttgc gccgtgcggg acatccggta ctacggcgga     360
tctcagggca acctgatctt cggcaagggc accaagctga gcgtgaagcc caac           414

<210> 162
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain WT

<400> 162
atggcctctg cacccatctc gatgcttgcg atgctcttca cattgagtgg gctgagagct      60
cagtcagtgg ctcagccgga agatcaggtc aacgttgctg aagggaatcc tctgactgtg     120
aaatgcacct attcagtctc tggaaaccct tatctttttt ggtatgttca ataccccaac     180
cgaggcctcc agttccttct gaaatacatc acaggggata acctggttaa aggcagctat     240
ggctttgaag ctgaatttaa caagagccaa acctccttcc acctgaagaa accatctgcc     300
cttgtgagcg actccgcttt gtacttctgt gctgtgagag acattaggta ttatggagga     360
agccaaggaa atctcatctt tggaaaaggc actaaactct ctgttaaacc aaatatccag     420
aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc     480
ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat     540
atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg     600
gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca     660
gaagacacct tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc     720
tttgaaacag atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc     780
ctcctgaaag tggccgggtt taatctgctc atgacgctgc ggctgtggtc cagctga        837

<210> 163
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 alpha chain - Codon-Optimized, Cys Modified

<400> 163
atggccagcg cccccattag catgctggct atgctgttca ccctgagcgg cctgagagcc      60
cagtctgtgg cccagcctga ggaccaagtg aatgtggccg agggcaaccc cctgaccgtg     120
aagtgtacct acagcgtgtc cggcaacccc tacctgtttt ggtacgtgca gtaccccaac     180
cggggcctgc agttcctgct gaagtacatc accggcgaca acctcgtgaa gggcagctac     240
ggcttcgagg ccgagttcaa caagagccag accagcttcc acctgaagaa acccagcgcc     300
ctggtgtccg actccgccct gtatttttgc gccgtgcggg acatccggta ctacggcgga     360
tctcagggca acctgatctt cggcaagggc accaagctga gcgtgaagcc caacatccag     420
aaccccgacc ccgcagtgta ccagctgcgg gacagcaaga gcagcgacaa gagcgtgtgc     480
ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggacag cgacgtgtac     540
atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     600
gcctggtcca acaagagcga cttcgcctgc gccaacgcct tcaacaacag cattatcccc     660
gaggacacat tcttcccaag ccccgagagc agctgcgacg tgaagctggt ggaaaagagc     720
ttcgagacag acaccaacct gaacttccag aacctcagcg tgatcggctt ccggatcctg     780
ctgctgaagg tggccggctt caacctgctg atgaccctgc ggctgtggtc cagctga        837

<210> 164
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta chain variable domain WT

<400> 164
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc cgggtcctag taacaatgag     360
cagttcttcg ggccagggac acggctcacc gtgctagag                            399

<210> 165
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta chain variable domain - Codon Optimized

<400> 165
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagctctc ccggccctag caacaacgag     360
cagttcttcg gccctggcac ccggctgacc gtgctggaa                            399

<210> 166
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta chain WT

<400> 166
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc cgggtcctag taacaatgag     360
cagttcttcg ggccagggac acggctcacc gtgctagagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggc                                  933

<210> 167
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta chain - Codon-Optimized, Cys Modified

<400> 167
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagctctc ccggccctag caacaacgag     360
cagttcttcg gccctggcac ccggctgacc gtgctggaag atctgaagaa cgtgttcccc     420
ccagaggtgg ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc     600
ctgaacgaca gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga     780
gccgattgcg gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg     900
atggccatgg tcaagcggaa ggacagccgg ggc                                  933

<210> 168
<211> 1836
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta-P2A-WT375 alpha Construct - WT

<400> 168
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc cgggtcctag taacaatgag     360
cagttcttcg ggccagggac acggctcacc gtgctagagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggcctctgc acccatctcg    1020
atgcttgcga tgctcttcac attgagtggg ctgagagctc agtcagtggc tcagccggaa    1080
gatcaggtca acgttgctga agggaatcct ctgactgtga aatgcaccta ttcagtctct    1140
ggaaaccctt atcttttttg gtatgttcaa taccccaacc gaggcctcca gttccttctg    1200
aaatacatca caggggataa cctggttaaa ggcagctatg gctttgaagc tgaatttaac    1260
aagagccaaa cctccttcca cctgaagaaa ccatctgccc ttgtgagcga ctccgctttg    1320
tacttctgtg ctgtgagaga cattaggtat tatggaggaa gccaaggaaa tctcatcttt    1380
ggaaaaggca ctaaactctc tgttaaacca aatatccaga accctgaccc tgccgtgtac    1440
cagctgagag actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgattct    1500
caaacaaatg tgtcacaaag taaggattct gatgtgtata tcacagacaa aactgtgcta    1560
gacatgaggt ctatggactt caagagcaac agtgctgtgg cctggagcaa caaatctgac    1620
tttgcatgtg caaacgcctt caacaacagc attattccag aagacacctt cttccccagc    1680
ccagaaagtt cctgtgatgt caagctggtc gagaaaagct ttgaaacaga tacgaaccta    1740
aactttcaaa acctgtcagt gattgggttc cgaatcctcc tcctgaaagt ggccgggttt    1800
aatctgctca tgacgctgcg gctgtggtcc agctga                              1836

<210> 169
<211> 1836
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT375 beta-P2A-WT375 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 169
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagctctc ccggccctag caacaacgag     360
cagttcttcg gccctggcac ccggctgacc gtgctggaag atctgaagaa cgtgttcccc     420
ccagaggtgg ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc     600
ctgaacgaca gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga     780
gccgattgcg gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg     900
atggccatgg tcaagcggaa ggacagccgg ggcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggccagcgc ccccattagc    1020
atgctggcta tgctgttcac cctgagcggc ctgagagccc agtctgtggc ccagcctgag    1080
gaccaagtga atgtggccga gggcaacccc ctgaccgtga agtgtaccta cagcgtgtcc    1140
ggcaacccct acctgttttg gtacgtgcag taccccaacc ggggcctgca gttcctgctg    1200
aagtacatca ccggcgacaa cctcgtgaag ggcagctacg gcttcgaggc cgagttcaac    1260
aagagccaga ccagcttcca cctgaagaaa cccagcgccc tggtgtccga ctccgccctg    1320
tatttttgcg ccgtgcggga catccggtac tacggcggat ctcagggcaa cctgatcttc    1380
ggcaagggca ccaagctgag cgtgaagccc aacatccaga accccgaccc cgcagtgtac    1440
cagctgcggg acagcaagag cagcgacaag agcgtgtgcc tgttcaccga cttcgacagc    1500
cagaccaacg tgtcccagag caaggacagc gacgtgtaca tcaccgataa gtgcgtgctg    1560
gacatgcgga gcatggactt caagagcaac agcgccgtgg cctggtccaa caagagcgac    1620
ttcgcctgcg ccaacgcctt caacaacagc attatccccg aggacacatt cttcccaagc    1680
cccgagagca gctgcgacgt gaagctggtg gaaaagagct tcgagacaga caccaacctg    1740
aacttccaga acctcagcgt gatcggcttc cggatcctgc tgctgaaggt ggccggcttc    1800
aacctgctga tgaccctgcg gctgtggtcc agctga                              1836

<210> 170
<211> 411
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain variable domain WT

<400> 170
atgatgaaat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg      60
agccaacaga aggaggtgga gcaggatcct ggaccactca gtgttccaga gggagccatt     120
gtttctctca actgcactta cagcaacagt gcttttcaat acttcatgtg gtacagacag     180
tattccagaa aaggccctga gttgctgatg tacacatact ccagtggtaa caaagaagat     240
ggaaggttta cagcacaggt cgataaatcc agcaagtata tctccttgtt catcagagac     300
tcacagccca gtgattcagc cacctacctc tgtgcaattt acgggtgggg tggtggtgct     360
acaaacaagc tcatctttgg aactggcact ctgcttgctg tccagccaaa t              411

<210> 171
<211> 411
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain variable domain - Codon
      Optimized

<400> 171
atgatgaagt ccctgcgggt gctgctcgtg atcctgtggc tgcagctgag ctgggtgtgg      60
tcccagcaga aagaggtgga acaggaccct ggccctctga gcgtgccaga gggcgctatc     120
gtgtccctga actgcaccta cagcaacagc gccttccagt acttcatgtg gtacagacag     180
tacagccgga agggccccga gctgctgatg tacacctact ccagcggcaa caaagaggac     240
ggccggttca cagcccaggt ggacaagagc agcaagtaca tctccctgtt catccgggac     300
agccagccca gcgattccgc cacatacctg tgcgccatct acggctgggg aggcggagcc     360
accaacaagc tgatctttgg caccggcacc ctgctggccg tgcagcccaa t              411

<210> 172
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain WT

<400> 172
atgatgaaat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg      60
agccaacaga aggaggtgga gcaggatcct ggaccactca gtgttccaga gggagccatt     120
gtttctctca actgcactta cagcaacagt gcttttcaat acttcatgtg gtacagacag     180
tattccagaa aaggccctga gttgctgatg tacacatact ccagtggtaa caaagaagat     240
ggaaggttta cagcacaggt cgataaatcc agcaagtata tctccttgtt catcagagac     300
tcacagccca gtgattcagc cacctacctc tgtgcaattt acgggtgggg tggtggtgct     360
acaaacaagc tcatctttgg aactggcact ctgcttgctg tccagccaaa tatccagaac     420
cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta     480
ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc     540
acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc     600
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa     660
gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt     720
gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc     780
ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctga           834

<210> 173
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 alpha chain - Codon-Optimized, Cys Modified

<400> 173
atgatgaagt ccctgcgggt gctgctcgtg atcctgtggc tgcagctgag ctgggtgtgg      60
tcccagcaga aagaggtgga acaggaccct ggccctctga gcgtgccaga gggcgctatc     120
gtgtccctga actgcaccta cagcaacagc gccttccagt acttcatgtg gtacagacag     180
tacagccgga agggccccga gctgctgatg tacacctact ccagcggcaa caaagaggac     240
ggccggttca cagcccaggt ggacaagagc agcaagtaca tctccctgtt catccgggac     300
agccagccca gcgattccgc cacatacctg tgcgccatct acggctgggg aggcggagcc     360
accaacaagc tgatctttgg caccggcacc ctgctggccg tgcagcccaa tatccagaac     420
cccgaccctg cagtgtacca gctgcgggac agcaagagca gcgacaagag cgtgtgcctg     480
ttcaccgact tcgacagcca gaccaacgtg tcccagagca aggacagcga cgtgtacatc     540
accgataagt gcgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc     600
tggtccaaca agagcgactt cgcctgcgcc aacgccttca acaacagcat tatccccgag     660
gacacattct tcccaagccc cgagagcagc tgcgacgtga agctggtgga aaagagcttc     720
gagacagaca ccaacctgaa cttccagaac ctcagcgtga tcggcttccg gatcctgctg     780
ctgaaggtgg ccggcttcaa cctgctgatg accctgcggc tgtggtccag ctga           834

<210> 174
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta chain variable domain WT

<400> 174
atgggcacca gtctcctatg ctgggtggtc ctgggtttcc tagggacaga tcacacaggt      60
gctggagtct cccagtctcc caggtacaaa gtcacaaaga ggggacagga tgtagctctc     120
aggtgtgatc caatttcggg tcatgtatcc ctttattggt accgacaggc cctggggcag     180
ggcccagagt ttctgactta cttcaattat gaagcccaac aagacaaatc agggctgccc     240
aatgatcggt tctctgcaga gaggcctgag ggatccatct ccactctgac gatccagcgc     300
acagagcagc gggactcggc catgtatcgc tgtgccagca gcctctatgg cgggtcttcc     360
tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagag                     405

<210> 175
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta chain variable domain - Codon Optimized

<400> 175
atgggcacaa gcctgctgtg ttgggtggtg ctgggcttcc tgggcaccga tcatacaggc      60
gctggcgtgt cccagagccc ccggtacaaa gtgaccaaga ggggccagga cgtggccctg     120
agatgcgatc ctatcagcgg ccacgtgtcc ctgtactggt acagacaggc cctgggccag     180
ggacccgagt tcctgaccta cttcaactac gaggcccagc aggacaagag cggcctgccc     240
aacgatagat tcagcgccga aagacccgag ggcagcatca gcaccctgac catccagaga     300
accgagcagc gggacagcgc catgtacaga tgtgccagct ctctgtacgg cggcagcagc     360
tacgagcagt actttggccc tggcacccgg ctgaccgtga ccgag                     405

<210> 176
<211> 939
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta chain WT

<400> 176
atgggcacca gtctcctatg ctgggtggtc ctgggtttcc tagggacaga tcacacaggt      60
gctggagtct cccagtctcc caggtacaaa gtcacaaaga ggggacagga tgtagctctc     120
aggtgtgatc caatttcggg tcatgtatcc ctttattggt accgacaggc cctggggcag     180
ggcccagagt ttctgactta cttcaattat gaagcccaac aagacaaatc agggctgccc     240
aatgatcggt tctctgcaga gaggcctgag ggatccatct ccactctgac gatccagcgc     300
acagagcagc gggactcggc catgtatcgc tgtgccagca gcctctatgg cgggtcttcc     360
tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagaggacct gaaaaacgtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc     900
gtgctgatgg ccatggtcaa gagaaaggat tccagaggc                            939

<210> 177
<211> 939
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta chain - Codon-Optimized, Cys Modified

<400> 177
atgggcacaa gcctgctgtg ttgggtggtg ctgggcttcc tgggcaccga tcatacaggc      60
gctggcgtgt cccagagccc ccggtacaaa gtgaccaaga ggggccagga cgtggccctg     120
agatgcgatc ctatcagcgg ccacgtgtcc ctgtactggt acagacaggc cctgggccag     180
ggacccgagt tcctgaccta cttcaactac gaggcccagc aggacaagag cggcctgccc     240
aacgatagat tcagcgccga aagacccgag ggcagcatca gcaccctgac catccagaga     300
accgagcagc gggacagcgc catgtacaga tgtgccagct ctctgtacgg cggcagcagc     360
tacgagcagt actttggccc tggcacccgg ctgaccgtga ccgaggatct gaagaacgtg     420
ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag     600
cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg     780
ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac agccggggc                            939

<210> 178
<211> 1839
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta-P2A-WT378 alpha Construct - WT

<400> 178
atgggcacca gtctcctatg ctgggtggtc ctgggtttcc tagggacaga tcacacaggt      60
gctggagtct cccagtctcc caggtacaaa gtcacaaaga ggggacagga tgtagctctc     120
aggtgtgatc caatttcggg tcatgtatcc ctttattggt accgacaggc cctggggcag     180
ggcccagagt ttctgactta cttcaattat gaagcccaac aagacaaatc agggctgccc     240
aatgatcggt tctctgcaga gaggcctgag ggatccatct ccactctgac gatccagcgc     300
acagagcagc gggactcggc catgtatcgc tgtgccagca gcctctatgg cgggtcttcc     360
tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagaggacct gaaaaacgtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc     900
gtgctgatgg ccatggtcaa gagaaaggat tccagaggcg gttccggagc cacgaacttc     960
tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgat gaaatccttg    1020
agagttttac tggtgatcct gtggcttcag ttaagctggg tttggagcca acagaaggag    1080
gtggagcagg atcctggacc actcagtgtt ccagagggag ccattgtttc tctcaactgc    1140
acttacagca acagtgcttt tcaatacttc atgtggtaca gacagtattc cagaaaaggc    1200
cctgagttgc tgatgtacac atactccagt ggtaacaaag aagatggaag gtttacagca    1260
caggtcgata aatccagcaa gtatatctcc ttgttcatca gagactcaca gcccagtgat    1320
tcagccacct acctctgtgc aatttacggg tggggtggtg gtgctacaaa caagctcatc    1380
tttggaactg gcactctgct tgctgtccag ccaaatatcc agaaccctga ccctgccgtg    1440
taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat    1500
tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg    1560
ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct    1620
gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc    1680
agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac    1740
ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg    1800
tttaatctgc tcatgacgct gcggctgtgg tccagctga                           1839

<210> 179
<211> 1839
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT378 beta-P2A-WT378 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 179
atgggcacaa gcctgctgtg ttgggtggtg ctgggcttcc tgggcaccga tcatacaggc      60
gctggcgtgt cccagagccc ccggtacaaa gtgaccaaga ggggccagga cgtggccctg     120
agatgcgatc ctatcagcgg ccacgtgtcc ctgtactggt acagacaggc cctgggccag     180
ggacccgagt tcctgaccta cttcaactac gaggcccagc aggacaagag cggcctgccc     240
aacgatagat tcagcgccga aagacccgag ggcagcatca gcaccctgac catccagaga     300
accgagcagc gggacagcgc catgtacaga tgtgccagct ctctgtacgg cggcagcagc     360
tacgagcagt actttggccc tggcacccgg ctgaccgtga ccgaggatct gaagaacgtg     420
ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag     600
cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg     780
ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc     960
tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgat gaagtccctg    1020
cgggtgctgc tcgtgatcct gtggctgcag ctgagctggg tgtggtccca gcagaaagag    1080
gtggaacagg accctggccc tctgagcgtg ccagagggcg ctatcgtgtc cctgaactgc    1140
acctacagca acagcgcctt ccagtacttc atgtggtaca gacagtacag ccggaagggc    1200
cccgagctgc tgatgtacac ctactccagc ggcaacaaag aggacggccg gttcacagcc    1260
caggtggaca agagcagcaa gtacatctcc ctgttcatcc gggacagcca gcccagcgat    1320
tccgccacat acctgtgcgc catctacggc tggggaggcg gagccaccaa caagctgatc    1380
tttggcaccg gcaccctgct ggccgtgcag cccaatatcc agaaccccga ccctgcagtg    1440
taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac    1500
agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg    1560
ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc    1620
gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca    1680
agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac    1740
ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc    1800
ttcaacctgc tgatgaccct gcggctgtgg tccagctga                           1839

<210> 180
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain variable domain WT

<400> 180
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc      60
caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc     120
tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat     180
tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga     240
aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc     300
cagcccagtg attcagccac ctacctctgt gccgtgggcg gatctggggg ttaccagaaa     360
gttacctttg gaattggaac aaagctccaa gtcatcccaa at                        402

<210> 181
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain variable domain - Codon
      Optimized

<400> 181
atgaagtccc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgagcg tgccagaagg cgctatcgcc     120
agcctgaact gcacctacag cgacagaggc agccagagct tcttctggta cagacagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggttcaccg cccagctgaa caaggccagc cagtacgtgt ccctgctgat cagagacagc     300
cagcccagcg acagcgccac ctatctgtgt gccgtgggag gctctggcgg ctaccagaaa     360
gtgaccttcg gcatcggcac caagctgcaa gtgatcccca ac                        402

<210> 182
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain WT

<400> 182
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc      60
caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc     120
tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat     180
tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga     240
aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc     300
cagcccagtg attcagccac ctacctctgt gccgtgggcg gatctggggg ttaccagaaa     360
gttacctttg gaattggaac aaagctccaa gtcatcccaa atatccagaa ccctgaccct     420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat     480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa     540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac     600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc     660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat     720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg     780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                     825

<210> 183
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 alpha chain - Codon-Optimized, Cys Modified

<400> 183
atgaagtccc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgagcg tgccagaagg cgctatcgcc     120
agcctgaact gcacctacag cgacagaggc agccagagct tcttctggta cagacagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggttcaccg cccagctgaa caaggccagc cagtacgtgt ccctgctgat cagagacagc     300
cagcccagcg acagcgccac ctatctgtgt gccgtgggag gctctggcgg ctaccagaaa     360
gtgaccttcg gcatcggcac caagctgcaa gtgatcccca acatccagaa ccccgacccc     420
gcagtgtacc agctgcggga cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac     480
ttcgacagcc agaccaacgt gtcccagagc aaggacagcg acgtgtacat caccgataag     540
tgcgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac     600
aagagcgact tcgcctgcgc caacgccttc aacaacagca ttatccccga ggacacattc     660
ttcccaagcc ccgagagcag ctgcgacgtg aagctggtgg aaaagagctt cgagacagac     720
accaacctga acttccagaa cctcagcgtg atcggcttcc ggatcctgct gctgaaggtg     780
gccggcttca acctgctgat gaccctgcgg ctgtggtcca gctga                     825

<210> 184
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta chain variable domain WT

<400> 184
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagcg ggagggccgg ggttggggag     360
ctgttttttg gagaaggctc taggctgacc gtactggag                            399

<210> 185
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta chain variable domain - Codon Optimized

<400> 185
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg gcagagccgg cgtgggcgag     360
ctgttttttg gcgagggcag caggctgacc gtgctggaa                            399

<210> 186
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta chain WT

<400> 186
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagcg ggagggccgg ggttggggag     360
ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggc                                  933

<210> 187
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta chain - Codon-Optimized, Cys Modified

<400> 187
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg gcagagccgg cgtgggcgag     360
ctgttttttg gcgagggcag caggctgacc gtgctggaag atctgaagaa cgtgttcccc     420
ccagaggtgg ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc     600
ctgaacgaca gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga     780
gccgattgcg gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg     900
atggccatgg tcaagcggaa ggacagccgg ggc                                  933

<210> 188
<211> 1824
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta-P2A-WT379 alpha Construct - WT

<400> 188
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagcg ggagggccgg ggttggggag     360
ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tgaaatcctt gagagtttta    1020
ctagtgatcc tgtggcttca gttgagctgg gtttggagcc aacagaagga ggtggagcag    1080
aattctggac ccctcagtgt tccagaggga gccattgcct ctctcaactg cacttacagt    1140
gaccgaggtt cccagtcctt cttctggtac agacaatatt ctgggaaaag ccctgagttg    1200
ataatgttca tatactccaa tggtgacaaa gaagatggaa ggtttacagc acagctcaat    1260
aaagccagcc agtatgtttc tctgctcatc agagactccc agcccagtga ttcagccacc    1320
tacctctgtg ccgtgggcgg atctgggggt taccagaaag ttacctttgg aattggaaca    1380
aagctccaag tcatcccaaa tatccagaac cctgaccctg ccgtgtacca gctgagagac    1440
tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca aacaaatgtg    1500
tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga catgaggtct    1560
atggacttca agagcaacag tgctgtggcc tggagcaaca aatctgactt tgcatgtgca    1620
aacgccttca acaacagcat tattccagaa gacaccttct tccccagccc agaaagttcc    1680
tgtgatgtca agctggtcga gaaaagcttt gaaacagata cgaacctaaa ctttcaaaac    1740
ctgtcagtga ttgggttccg aatcctcctc ctgaaagtgg ccgggtttaa tctgctcatg    1800
acgctgcggc tgtggtccag ctga                                           1824

<210> 189
<211> 1824
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT379 beta-P2A-WT379 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 189
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg gcagagccgg cgtgggcgag     360
ctgttttttg gcgagggcag caggctgacc gtgctggaag atctgaagaa cgtgttcccc     420
ccagaggtgg ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc     600
ctgaacgaca gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga     780
gccgattgcg gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg     900
atggccatgg tcaagcggaa ggacagccgg ggcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tgaagtccct gcgggtgctg    1020
ctcgtgatcc tgtggctgca gctgagctgg gtgtggtccc agcagaaaga ggtggaacag    1080
aacagcggcc ctctgagcgt gccagaaggc gctatcgcca gcctgaactg cacctacagc    1140
gacagaggca gccagagctt cttctggtac agacagtaca gcggcaagag ccccgagctg    1200
atcatgttca tctacagcaa cggcgacaaa gaggacggcc ggttcaccgc ccagctgaac    1260
aaggccagcc agtacgtgtc cctgctgatc agagacagcc agcccagcga cagcgccacc    1320
tatctgtgtg ccgtgggagg ctctggcggc taccagaaag tgaccttcgg catcggcacc    1380
aagctgcaag tgatccccaa catccagaac cccgaccccg cagtgtacca gctgcgggac    1440
agcaagagca gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg    1500
tcccagagca aggacagcga cgtgtacatc accgataagt gcgtgctgga catgcggagc    1560
atggacttca agagcaacag cgccgtggcc tggtccaaca agagcgactt cgcctgcgcc    1620
aacgccttca acaacagcat tatccccgag gacacattct tcccaagccc cgagagcagc    1680
tgcgacgtga agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac    1740
ctcagcgtga tcggcttccg gatcctgctg ctgaaggtgg ccggcttcaa cctgctgatg    1800
accctgcggc tgtggtccag ctga                                           1824

<210> 190
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain variable domain WT

<400> 190
atgatatcct tgagagtttt actggtgatc ctgtggcttc agttaagctg ggtttggagc      60
caacggaagg aggtggagca ggatcctgga cccttcaatg ttccagaggg agccactgtc     120
gctttcaact gtacttacag caacagtgct tctcagtctt tcttctggta cagacaggat     180
tgcaggaaag aacctaagtt gctgatgtcc gtatactcca gtggtaatga agatggaagg     240
tttacagcac agctcaatag agccagccag tatatttccc tgctcatcag agactccaag     300
ctcagtgatt cagccaccta cctctgtgtg gtgaaacccg accctggggc tgggagttac     360
caactcactt tcgggaaggg gaccaaactc tcggtcatac caaat                     405

<210> 191
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain variable domain - Codon
      Optimized

<400> 191
atgatcagcc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcggaaag aggtggaaca ggaccctggc cccttcaacg tgccagaggg cgccaccgtg     120
gccttcaact gcacctacag caacagcgcc agccagagct tcttctggta cagacaggac     180
tgccggaaag aacccaagct gctgatgagc gtgtacagca gcggcaacga ggacggcaga     240
ttcaccgccc agctgaacag agcctcccag tacatctccc tgctgatccg ggacagcaag     300
ctgagcgaca gcgccaccta cctgtgcgtc gtgaagcctg atcctggcgc cggaagctac     360
cagctgacct ttggcaaggg caccaagctg tccgtgatcc ccaac                     405

<210> 192
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain WT

<400> 192
atgatatcct tgagagtttt actggtgatc ctgtggcttc agttaagctg ggtttggagc      60
caacggaagg aggtggagca ggatcctgga cccttcaatg ttccagaggg agccactgtc     120
gctttcaact gtacttacag caacagtgct tctcagtctt tcttctggta cagacaggat     180
tgcaggaaag aacctaagtt gctgatgtcc gtatactcca gtggtaatga agatggaagg     240
tttacagcac agctcaatag agccagccag tatatttccc tgctcatcag agactccaag     300
ctcagtgatt cagccaccta cctctgtgtg gtgaaacccg accctggggc tgggagttac     360
caactcactt tcgggaaggg gaccaaactc tcggtcatac caaatatcca gaaccctgac     420
cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc     480
gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac     540
aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc     600
aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc     660
ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca     720
gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa     780
gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                  828

<210> 193
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 alpha chain - Codon-Optimized, Cys Modified

<400> 193
atgatcagcc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcggaaag aggtggaaca ggaccctggc cccttcaacg tgccagaggg cgccaccgtg     120
gccttcaact gcacctacag caacagcgcc agccagagct tcttctggta cagacaggac     180
tgccggaaag aacccaagct gctgatgagc gtgtacagca gcggcaacga ggacggcaga     240
ttcaccgccc agctgaacag agcctcccag tacatctccc tgctgatccg ggacagcaag     300
ctgagcgaca gcgccaccta cctgtgcgtc gtgaagcctg atcctggcgc cggaagctac     360
cagctgacct ttggcaaggg caccaagctg tccgtgatcc ccaacatcca gaaccccgac     420
cccgcagtgt accagctgcg ggacagcaag agcagcgaca agagcgtgtg cctgttcacc     480
gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta catcaccgat     540
aagtgcgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc     600
aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcattatccc cgaggacaca     660
ttcttcccaa gccccgagag cagctgcgac gtgaagctgg tggaaaagag cttcgagaca     720
gacaccaacc tgaacttcca gaacctcagc gtgatcggct tccggatcct gctgctgaag     780
gtggccggct tcaacctgct gatgaccctg cggctgtggt ccagctga                  828

<210> 194
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain variable domain WT

<400> 194
atgagcctcg ggctcctgtg ctgtggggcc ttttctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccgg gtcctgaaga caggacagag catgacactg     120
ctgtgtgccc aggatatgaa ccatgaatac atgtactggt atcgacaaga cccaggcatg     180
gggctgaggc tgattcatta ctcagttggt gagggtacaa ctgccaaagg agaggtccct     240
gatggctaca atgtctccag attaaaaaaa cagaatttcc tgctggggtt ggagtcggct     300
gctccctccc aaacatctgt gtacttctgt gccagcaggg gttatcacag gttaaacaat     360
gagcagttct tcgggccagg gacacggctc accgtgctag ag                        402

<210> 195
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain variable domain - Codon
      Optimized

<400> 195
atgtctctgg gcctgctgtg ctgtggcgcc ttctctctgc tgtgggccgg acctgtgaat      60
gccggcgtga cccagacccc caagttccgg gtgctgaaaa ccggccagag catgaccctg     120
ctgtgtgccc aggacatgaa ccacgagtac atgtattggt acagacagga ccccggcatg     180
ggcctgcggc tgatccacta ttctgtgggc gagggcacca ccgccaaggg cgaagtgcct     240
gatggctaca acgtgtcccg gctgaagaag cagaacttcc tgctgggcct ggaaagcgcc     300
gctcctagcc agaccagcgt gtacttctgt gccagccggg gctaccaccg gctgaacaac     360
gagcagttct tcggccctgg cacccggctg accgtgctgg aa                        402

<210> 196
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain WT

<400> 196
atgagcctcg ggctcctgtg ctgtggggcc ttttctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccgg gtcctgaaga caggacagag catgacactg     120
ctgtgtgccc aggatatgaa ccatgaatac atgtactggt atcgacaaga cccaggcatg     180
gggctgaggc tgattcatta ctcagttggt gagggtacaa ctgccaaagg agaggtccct     240
gatggctaca atgtctccag attaaaaaaa cagaatttcc tgctggggtt ggagtcggct     300
gctccctccc aaacatctgt gtacttctgt gccagcaggg gttatcacag gttaaacaat     360
gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggc                               936

<210> 197
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta chain - Codon-Optimized, Cys Modified

<400> 197
atgtctctgg gcctgctgtg ctgtggcgcc ttctctctgc tgtgggccgg acctgtgaat      60
gccggcgtga cccagacccc caagttccgg gtgctgaaaa ccggccagag catgaccctg     120
ctgtgtgccc aggacatgaa ccacgagtac atgtattggt acagacagga ccccggcatg     180
ggcctgcggc tgatccacta ttctgtgggc gagggcacca ccgccaaggg cgaagtgcct     240
gatggctaca acgtgtcccg gctgaagaag cagaacttcc tgctgggcct ggaaagcgcc     300
gctcctagcc agaccagcgt gtacttctgt gccagccggg gctaccaccg gctgaacaac     360
gagcagttct tcggccctgg cacccggctg accgtgctgg aagatctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggc                               936

<210> 198
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta-P2A-WT3710 alpha Construct - WT

<400> 198
atgagcctcg ggctcctgtg ctgtggggcc ttttctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccgg gtcctgaaga caggacagag catgacactg     120
ctgtgtgccc aggatatgaa ccatgaatac atgtactggt atcgacaaga cccaggcatg     180
gggctgaggc tgattcatta ctcagttggt gagggtacaa ctgccaaagg agaggtccct     240
gatggctaca atgtctccag attaaaaaaa cagaatttcc tgctggggtt ggagtcggct     300
gctccctccc aaacatctgt gtacttctgt gccagcaggg gttatcacag gttaaacaat     360
gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgatatc cttgagagtt    1020
ttactggtga tcctgtggct tcagttaagc tgggtttgga gccaacggaa ggaggtggag    1080
caggatcctg gacccttcaa tgttccagag ggagccactg tcgctttcaa ctgtacttac    1140
agcaacagtg cttctcagtc tttcttctgg tacagacagg attgcaggaa agaacctaag    1200
ttgctgatgt ccgtatactc cagtggtaat gaagatggaa ggtttacagc acagctcaat    1260
agagccagcc agtatatttc cctgctcatc agagactcca agctcagtga ttcagccacc    1320
tacctctgtg tggtgaaacc cgaccctggg gctgggagtt accaactcac tttcgggaag    1380
gggaccaaac tctcggtcat accaaatatc cagaaccctg accctgccgt gtaccagctg    1440
agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca    1500
aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg    1560
aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca    1620
tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa    1680
agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt    1740
caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg    1800
ctcatgacgc tgcggctgtg gtccagctga                                     1830

<210> 199
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT3710 beta-P2A-WT3710 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 199
atgtctctgg gcctgctgtg ctgtggcgcc ttctctctgc tgtgggccgg acctgtgaat      60
gccggcgtga cccagacccc caagttccgg gtgctgaaaa ccggccagag catgaccctg     120
ctgtgtgccc aggacatgaa ccacgagtac atgtattggt acagacagga ccccggcatg     180
ggcctgcggc tgatccacta ttctgtgggc gagggcacca ccgccaaggg cgaagtgcct     240
gatggctaca acgtgtcccg gctgaagaag cagaacttcc tgctgggcct ggaaagcgcc     300
gctcctagcc agaccagcgt gtacttctgt gccagccggg gctaccaccg gctgaacaac     360
gagcagttct tcggccctgg cacccggctg accgtgctgg aagatctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgatcag cctgcgggtg    1020
ctgctcgtga tcctgtggct gcagctgagc tgggtgtggt cccagcggaa agaggtggaa    1080
caggaccctg gccccttcaa cgtgccagag ggcgccaccg tggccttcaa ctgcacctac    1140
agcaacagcg ccagccagag cttcttctgg tacagacagg actgccggaa agaacccaag    1200
ctgctgatga gcgtgtacag cagcggcaac gaggacggca gattcaccgc ccagctgaac    1260
agagcctccc agtacatctc cctgctgatc cgggacagca agctgagcga cagcgccacc    1320
tacctgtgcg tcgtgaagcc tgatcctggc gccggaagct accagctgac ctttggcaag    1380
ggcaccaagc tgtccgtgat ccccaacatc cagaaccccg accccgcagt gtaccagctg    1440
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc    1500
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg    1560
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc    1620
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag    1680
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc    1740
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg    1800
ctgatgaccc tgcggctgtg gtccagctga                                     1830

<210> 200
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain variable domain WT

<400> 200
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt      60
gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact     120
ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc     180
agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca     240
gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc     300
gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagctcg ggaagaaacc     360
agtggctcta ggttgacctt tggggaagga acacagctca cagtgaatcc tgat           414

<210> 201
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain variable domain - Codon
      Optimized

<400> 201
atgagcctga gcagcctgct gaaagtcgtg accgccagcc tgtggctggg acctggaatc      60
gcccagaaga tcacccagac ccagcccggc atgttcgtgc aggaaaaaga agccgtgacc     120
ctggactgca cctacgacac cagcgaccct agctacggcc tgttctggta caagcagccc     180
agcagcggcg agatgatctt cctgatctac cagggcagct acgaccagca gaacgccacc     240
gagggccggt acagcctgaa cttccagaag gcccggaagt ccgccaacct cgtgatcagc     300
gctagccagc tgggcgacag cgccatgtac ttttgcgcca tgcgggccag agaggaaacc     360
agcggcagca gactgacctt cggcgagggc acacagctga ccgtgaaccc cgac           414

<210> 202
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain WT

<400> 202
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt      60
gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact     120
ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc     180
agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca     240
gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc     300
gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagctcg ggaagaaacc     360
agtggctcta ggttgacctt tggggaagga acacagctca cagtgaatcc tgatatccag     420
aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc     480
ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat     540
atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg     600
gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca     660
gaagacacct tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc     720
tttgaaacag atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc     780
ctcctgaaag tggccgggtt taatctgctc atgacgctgc ggctgtggtc cagctga        837

<210> 203
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 alpha chain - Codon-Optimized, Cys Modified

<400> 203
atgagcctga gcagcctgct gaaagtcgtg accgccagcc tgtggctggg acctggaatc      60
gcccagaaga tcacccagac ccagcccggc atgttcgtgc aggaaaaaga agccgtgacc     120
ctggactgca cctacgacac cagcgaccct agctacggcc tgttctggta caagcagccc     180
agcagcggcg agatgatctt cctgatctac cagggcagct acgaccagca gaacgccacc     240
gagggccggt acagcctgaa cttccagaag gcccggaagt ccgccaacct cgtgatcagc     300
gctagccagc tgggcgacag cgccatgtac ttttgcgcca tgcgggccag agaggaaacc     360
agcggcagca gactgacctt cggcgagggc acacagctga ccgtgaaccc cgacatccag     420
aaccccgatc ccgcagtgta ccagctgcgg gacagcaaga gcagcgacaa gagcgtgtgc     480
ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggacag cgacgtgtac     540
atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     600
gcctggtcca acaagagcga cttcgcctgc gccaacgcct tcaacaacag cattatcccc     660
gaggacacat tcttcccaag ccccgagagc agctgcgacg tgaagctggt ggaaaagagc     720
ttcgagacag acaccaacct gaacttccag aacctcagcg tgatcggctt ccggatcctg     780
ctgctgaagg tggccggctt caacctgctg atgaccctgc ggctgtggtc cagctga        837

<210> 204
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain variable domain WT

<400> 204
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc aagatggccg gtcccggccc     360
cagcattttg gtgatgggac tcgactctcc atcctagag                            399

<210> 205
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain variable domain - Codon Optimized

<400> 205
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagcagcc aggacggcag aagcagacct     360
cagcactttg gcgacggcac ccggctgagc atcctggaa                            399

<210> 206
<211> 528
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain constant domain WT

<400> 206
gacctgaaca aggtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc      60
tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttcttccc cgaccacgtg     120
gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac ggacccgcag     180
cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg     240
gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac     300
gggctctcgg agaatgacga gtggacccag gatagggcca aacccgtcac ccagatcgtc     360
agcgccgagg cctggggtag agcagactgt ggctttacct cggtgtccta ccagcaaggg     420
gtcctgtctg ccaccatcct ctatgagatc ctgctaggga aggccaccct gtatgctgtg     480
ctggtcagcg cccttgtgtt gatggccatg gtcaagagaa aggatttc                  528

<210> 207
<211> 528
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain constant domain - Cys Modified

<400> 207
gacctgaaca aggtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc      60
tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttcttccc cgaccacgtg     120
gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtctgcac ggacccgcag     180
cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg     240
gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac     300
gggctctcgg agaatgacga gtggacccag gatagggcca aacccgtcac ccagatcgtc     360
agcgccgagg cctggggtag agcagactgt ggctttacct cggtgtccta ccagcaaggg     420
gtcctgtctg ccaccatcct ctatgagatc ctgctaggga aggccaccct gtatgctgtg     480
ctggtcagcg cccttgtgtt gatggccatg gtcaagagaa aggatttc                  528

<210> 208
<211> 528
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain constant domain - Codon Optimized

<400> 208
gatctgaaca aggtgttccc cccagaggtg gccgtgttcg agccttctga ggccgagatc      60
tcccacaccc agaaagccac cctcgtgtgc ctggccaccg gctttttccc cgaccacgtg     120
gaactgtctt ggtgggtcaa cggcaaagag gtgcactccg gcgtgagcac cgatccccag     180
cctctgaaag aacagcccgc cctgaacgac agccggtact gcctgagcag cagactgaga     240
gtgtccgcca ccttctggca gaacccccgg aaccacttca gatgccaggt gcagttctac     300
ggcctgagcg agaacgacga gtggacccag gacagagcca agcccgtgac acagatcgtg     360
tctgccgaag cctggggcag agccgattgc ggctttacct ccgtgtccta tcagcagggc     420
gtgctgagcg ccacaatcct gtacgagatc ctgctgggca aggccaccct gtacgccgtg     480
ctggtgtctg ccctggtgct gatggccatg gtcaagcgga aggacttc                  528

<210> 209
<211> 528
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain constant domain -
      Codon-Optimized, Cys Modified

<400> 209
gatctgaaca aggtgttccc cccagaggtg gccgtgttcg agccttctga ggccgagatc      60
tcccacaccc agaaagccac cctcgtgtgc ctggccaccg gctttttccc cgaccacgtg     120
gaactgtctt ggtgggtcaa cggcaaagag gtgcactccg gcgtgtgcac cgatccccag     180
cctctgaaag aacagcccgc cctgaacgac agccggtact gcctgagcag cagactgaga     240
gtgtccgcca ccttctggca gaacccccgg aaccacttca gatgccaggt gcagttctac     300
ggcctgagcg agaacgacga gtggacccag gacagagcca agcccgtgac acagatcgtg     360
tctgccgaag cctggggcag agccgattgc ggctttacct ccgtgtccta tcagcagggc     420
gtgctgagcg ccacaatcct gtacgagatc ctgctgggca aggccaccct gtacgccgtg     480
ctggtgtctg ccctggtgct gatggccatg gtcaagcgga aggacttc                  528

<210> 210
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain WT

<400> 210
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc aagatggccg gtcccggccc     360
cagcattttg gtgatgggac tcgactctcc atcctagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttc                                         927

<210> 211
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta chain - Codon-Optimized, Cys Modified

<400> 211
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagcagcc aggacggcag aagcagacct     360
cagcactttg gcgacggcac ccggctgagc atcctggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttc                                         927

<210> 212
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta-P2A-WT371 alpha Construct - WT

<400> 212
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tcccttggac      60
acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt     120
aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa     180
tttctgaaga taatgtttag ctacaataat aaggagctca ttataaatga aacagttcca     240
aatcgcttct cacctaaatc tccagacaaa gctcacttaa atcttcacat caattccctg     300
gagcttggtg actctgctgt gtatttctgt gccagcagcc aagatggccg gtcccggccc     360
cagcattttg gtgatgggac tcgactctcc atcctagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgtcac tttctagcct gctgaaggtg    1020
gtcacagctt cactgtggct aggacctggc attgcccaga agataactca aacccaacca    1080
ggaatgttcg tgcaggaaaa ggaggctgtg actctggact gcacatatga caccagtgat    1140
ccaagttatg gtctattctg gtacaagcag cccagcagtg gggaaatgat ttttcttatt    1200
tatcaggggt cttatgacca gcaaaatgca acagaaggtc gctactcatt gaatttccag    1260
aaggcaagaa aatccgccaa ccttgtcatc tccgcttcac aactggggga ctcagcaatg    1320
tacttctgtg caatgagagc tcgggaagaa accagtggct ctaggttgac ctttggggaa    1380
ggaacacagc tcacagtgaa tcctgatatc cagaaccctg accctgccgt gtaccagctg    1440
agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca    1500
aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg    1560
aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca    1620
tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa    1680
agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt    1740
caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg    1800
ctcatgacgc tgcggctgtg gtccagctga                                     1830

<210> 213
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT371 beta-P2A-WT371 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 213
atgggctgca gactgctgtg ctgcgtggtg ttctgcctgc tgcaagccgg ccctctggat      60
accgccgtgt ctcagacccc caagtacctc gtgacccaga tgggcaacga caagagcatc     120
aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa     180
ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc     240
aaccggttca gccccaagag ccccgataag gcccacctga acctgcacat caacagcctg     300
gaactgggcg acagcgccgt gtacttctgt gccagcagcc aggacggcag aagcagacct     360
cagcactttg gcgacggcac ccggctgagc atcctggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgagcc tgagcagcct gctgaaagtc    1020
gtgaccgcca gcctgtggct gggacctgga atcgcccaga agatcaccca gacccagccc    1080
ggcatgttcg tgcaggaaaa agaagccgtg accctggact gcacctacga caccagcgac    1140
cctagctacg gcctgttctg gtacaagcag cccagcagcg gcgagatgat cttcctgatc    1200
taccagggca gctacgacca gcagaacgcc accgagggcc ggtacagcct gaacttccag    1260
aaggcccgga agtccgccaa cctcgtgatc agcgctagcc agctgggcga cagcgccatg    1320
tacttttgcg ccatgcgggc cagagaggaa accagcggca gcagactgac cttcggcgag    1380
ggcacacagc tgaccgtgaa ccccgacatc cagaaccccg atcccgcagt gtaccagctg    1440
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc    1500
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg    1560
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc    1620
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag    1680
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc    1740
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg    1800
ctgatgaccc tgcggctgtg gtccagctga                                     1830

<210> 214
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain variable domain WT

<400> 214
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc      60
caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc     120
tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat     180
tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga     240
aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc     300
cagcccagtg attcagccac ctacctctgt gccgttccta cctcaggaac ctacaaatac     360
atctttggaa caggcaccag gctgaaggtt ttagcaaat                            399

<210> 215
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain variable domain - Codon
      Optimized

<400> 215
atgaagtccc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgagcg tgccagaagg cgctatcgcc     120
agcctgaact gcacctacag cgacagaggc agccagagct tcttctggta cagacagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggttcaccg cccagctgaa caaggccagc cagtacgtgt ccctgctgat cagagacagc     300
cagcccagcg acagcgccac ctatctgtgt gccgtgccta ccagcggcac ctacaagtac     360
atcttcggca ccggcacccg gctgaaggtg ctggccaac                            399

<210> 216
<211> 822
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain WT

<400> 216
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc      60
caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc     120
tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat     180
tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga     240
aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc     300
cagcccagtg attcagccac ctacctctgt gccgttccta cctcaggaac ctacaaatac     360
atctttggaa caggcaccag gctgaaggtt ttagcaaata tccagaaccc tgaccctgcc     420
gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt     480
gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaaaact     540
gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa     600
tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc     660
cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg     720
aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc     780
gggtttaatc tgctcatgac gctgcggctg tggtccagct ga                        822

<210> 217
<211> 822
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 alpha chain - Codon-Optimized, Cys Modified

<400> 217
atgaagtccc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgagcg tgccagaagg cgctatcgcc     120
agcctgaact gcacctacag cgacagaggc agccagagct tcttctggta cagacagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggttcaccg cccagctgaa caaggccagc cagtacgtgt ccctgctgat cagagacagc     300
cagcccagcg acagcgccac ctatctgtgt gccgtgccta ccagcggcac ctacaagtac     360
atcttcggca ccggcacccg gctgaaggtg ctggccaaca tccagaaccc cgaccccgca     420
gtgtaccagc tgcgggacag caagagcagc gacaagagcg tgtgcctgtt caccgacttc     480
gacagccaga ccaacgtgtc ccagagcaag gacagcgacg tgtacatcac cgataagtgc     540
gtgctggaca tgcggagcat ggacttcaag agcaacagcg ccgtggcctg gtccaacaag     600
agcgacttcg cctgcgccaa cgccttcaac aacagcatta tccccgagga cacattcttc     660
ccaagccccg agagcagctg cgacgtgaag ctggtggaaa agagcttcga gacagacacc     720
aacctgaact tccagaacct cagcgtgatc ggcttccgga tcctgctgct gaaggtggcc     780
ggcttcaacc tgctgatgac cctgcggctg tggtccagct ga                        822

<210> 218
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta  chain variable domain WT

<400> 218
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagta tcagggattc aagcaatcag     360
ccccagcatt ttggtgatgg gactcgactc tccatcctag ag                        402

<210> 219
<211> 402
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta chain variable domain - Codon Optimized

<400> 219
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgc gccagcagca tccgggacag cagcaatcag     360
cctcagcact tcggcgacgg cacccggctg agcatcctgg aa                        402

<210> 220
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta chain WT

<400> 220
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagta tcagggattc aagcaatcag     360
ccccagcatt ttggtgatgg gactcgactc tccatcctag aggacctgaa caaggtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttcttc cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggctttac ctcggtgtcc taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcctgctagg gaaggccacc ctgtatgctg tgctggtcag cgcccttgtg     900
ttgatggcca tggtcaagag aaaggatttc                                      930

<210> 221
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta chain - Codon-Optimized, Cys Modified

<400> 221
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgc gccagcagca tccgggacag cagcaatcag     360
cctcagcact tcggcgacgg cacccggctg agcatcctgg aagatctgaa caaggtgttc     420
cccccagagg tggccgtgtt cgagccttct gaggccgaga tctcccacac ccagaaagcc     480
accctcgtgt gcctggccac cggctttttc cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcactc cggcgtgtgc accgatcccc agcctctgaa agaacagccc     600
gccctgaacg acagccggta ctgcctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggacagagc caagcccgtg acacagatcg tgtctgccga agcctggggc     780
agagccgatt gcggctttac ctccgtgtcc tatcagcagg gcgtgctgag cgccacaatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc tgccctggtg     900
ctgatggcca tggtcaagcg gaaggacttc                                      930

<210> 222
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta-P2A-WT372 alpha Construct - WT

<400> 222
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagta tcagggattc aagcaatcag     360
ccccagcatt ttggtgatgg gactcgactc tccatcctag aggacctgaa caaggtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttcttc cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggctttac ctcggtgtcc taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcctgctagg gaaggccacc ctgtatgctg tgctggtcag cgcccttgtg     900
ttgatggcca tggtcaagag aaaggatttc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatga aatccttgag agttttacta    1020
gtgatcctgt ggcttcagtt gagctgggtt tggagccaac agaaggaggt ggagcagaat    1080
tctggacccc tcagtgttcc agagggagcc attgcctctc tcaactgcac ttacagtgac    1140
cgaggttccc agtccttctt ctggtacaga caatattctg ggaaaagccc tgagttgata    1200
atgttcatat actccaatgg tgacaaagaa gatggaaggt ttacagcaca gctcaataaa    1260
gccagccagt atgtttctct gctcatcaga gactcccagc ccagtgattc agccacctac    1320
ctctgtgccg ttcctacctc aggaacctac aaatacatct ttggaacagg caccaggctg    1380
aaggttttag caaatatcca gaaccctgac cctgccgtgt accagctgag agactctaaa    1440
tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa    1500
agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac    1560
ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc    1620
ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccagaaag ttcctgtgat    1680
gtcaagctgg tcgagaaaag ctttgaaaca gatacgaacc taaactttca aaacctgtca    1740
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg    1800
cggctgtggt ccagctga                                                  1818

<210> 223
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT372 beta-P2A-WT372 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 223
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgc gccagcagca tccgggacag cagcaatcag     360
cctcagcact tcggcgacgg cacccggctg agcatcctgg aagatctgaa caaggtgttc     420
cccccagagg tggccgtgtt cgagccttct gaggccgaga tctcccacac ccagaaagcc     480
accctcgtgt gcctggccac cggctttttc cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcactc cggcgtgtgc accgatcccc agcctctgaa agaacagccc     600
gccctgaacg acagccggta ctgcctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggacagagc caagcccgtg acacagatcg tgtctgccga agcctggggc     780
agagccgatt gcggctttac ctccgtgtcc tatcagcagg gcgtgctgag cgccacaatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc tgccctggtg     900
ctgatggcca tggtcaagcg gaaggacttc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatga agtccctgcg ggtgctgctc    1020
gtgatcctgt ggctgcagct gagctgggtg tggtcccagc agaaagaggt ggaacagaac    1080
agcggccctc tgagcgtgcc agaaggcgct atcgccagcc tgaactgcac ctacagcgac    1140
agaggcagcc agagcttctt ctggtacaga cagtacagcg gcaagagccc cgagctgatc    1200
atgttcatct acagcaacgg cgacaaagag gacggccggt tcaccgccca gctgaacaag    1260
gccagccagt acgtgtccct gctgatcaga gacagccagc ccagcgacag cgccacctat    1320
ctgtgtgccg tgcctaccag cggcacctac aagtacatct tcggcaccgg cacccggctg    1380
aaggtgctgg ccaacatcca gaaccccgac cccgcagtgt accagctgcg ggacagcaag    1440
agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag    1500
agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac    1560
ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc    1620
ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac    1680
gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc    1740
gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg    1800
cggctgtggt ccagctga                                                  1818

<210> 224
<211> 426
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain variable domain WT

<400> 224
atggccatgc tcctgggggc atcagtgctg attctgtggc ttcagccaga ctgggtaaac      60
agtcaacaga agaatgatga ccagcaagtt aagcaaaatt caccatccct gagcgtccag     120
gaaggaagaa tttctattct gaactgtgac tatactaaca gcatgtttga ttatttccta     180
tggtacaaaa aataccctgc tgaaggtcct acattcctga tatctataag ttccattaag     240
gataaaaatg aagatggaag attcactgtc ttcttaaaca aaagtgccaa gcacctctct     300
ctgcacattg tgccctccca gcctggagac tctgcagtgt acttctgtgc agcaggggct     360
cggggtggta ctagctatgg aaagctgaca tttggacaag ggaccatctt gactgtccat     420
ccaaat                                                                426

<210> 225
<211> 426
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain variable domain - Codon
      Optimized

<400> 225
atggctatgc tgctgggcgc ctctgtgctg atcctgtggc tgcagcccga ctgggtcaac      60
agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcag     120
gaaggccgga tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg     180
tggtacaaga agtaccccgc cgagggcccc accttcctga tctccatcag cagcatcaag     240
gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc     300
ctgcacatcg tgcctagcca gcctggcgat agcgccgtgt acttttgtgc cgctggcgct     360
agaggcggca ccagctatgg caagctgacc tttggccagg gcaccatcct gaccgtgcac     420
cccaac                                                                426

<210> 226
<211> 849
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain WT

<400> 226
atggccatgc tcctgggggc atcagtgctg attctgtggc ttcagccaga ctgggtaaac      60
agtcaacaga agaatgatga ccagcaagtt aagcaaaatt caccatccct gagcgtccag     120
gaaggaagaa tttctattct gaactgtgac tatactaaca gcatgtttga ttatttccta     180
tggtacaaaa aataccctgc tgaaggtcct acattcctga tatctataag ttccattaag     240
gataaaaatg aagatggaag attcactgtc ttcttaaaca aaagtgccaa gcacctctct     300
ctgcacattg tgccctccca gcctggagac tctgcagtgt acttctgtgc agcaggggct     360
cggggtggta ctagctatgg aaagctgaca tttggacaag ggaccatctt gactgtccat     420
ccaaatatcc agaaccctga ccctgccgtg taccagctga gagactctaa atccagtgac     480
aagtctgtct gcctattcac cgattttgat tctcaaacaa atgtgtcaca aagtaaggat     540
tctgatgtgt atatcacaga caaaactgtg ctagacatga ggtctatgga cttcaagagc     600
aacagtgctg tggcctggag caacaaatct gactttgcat gtgcaaacgc cttcaacaac     660
agcattattc cagaagacac cttcttcccc agcccagaaa gttcctgtga tgtcaagctg     720
gtcgagaaaa gctttgaaac agatacgaac ctaaactttc aaaacctgtc agtgattggg     780
ttccgaatcc tcctcctgaa agtggccggg tttaatctgc tcatgacgct gcggctgtgg     840
tccagctga                                                             849

<210> 227
<211> 849
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 alpha chain - Codon-Optimized, Cys Modified

<400> 227
atggctatgc tgctgggcgc ctctgtgctg atcctgtggc tgcagcccga ctgggtcaac      60
agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcag     120
gaaggccgga tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg     180
tggtacaaga agtaccccgc cgagggcccc accttcctga tctccatcag cagcatcaag     240
gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc     300
ctgcacatcg tgcctagcca gcctggcgat agcgccgtgt acttttgtgc cgctggcgct     360
agaggcggca ccagctatgg caagctgacc tttggccagg gcaccatcct gaccgtgcac     420
cccaacatcc agaaccccga ccctgcagtg taccagctgc gggacagcaa gagcagcgac     480
aagagcgtgt gcctgttcac cgacttcgac agccagacca acgtgtccca gagcaaggac     540
agcgacgtgt acatcaccga taagtgcgtg ctggacatgc ggagcatgga cttcaagagc     600
aacagcgccg tggcctggtc caacaagagc gacttcgcct gcgccaacgc cttcaacaac     660
agcattatcc ccgaggacac attcttccca agccccgaga gcagctgcga cgtgaagctg     720
gtggaaaaga gcttcgagac agacaccaac ctgaacttcc agaacctcag cgtgatcggc     780
ttccggatcc tgctgctgaa ggtggccggc ttcaacctgc tgatgaccct gcggctgtgg     840
tccagctga                                                             849

<210> 228
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta chain variable domain WT

<400> 228
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagtg ctcagggggc gtatggcaat     360
cagccccagc attttggtga tgggactcga ctctccatcc tagag                     405

<210> 229
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta chain variable domain - Codon Optimized

<400> 229
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg cccagggcgc ctacggaaat     360
cagcctcagc actttggcga cggcacccgg ctgagcatcc tggaa                     405

<210> 230
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta chain WT

<400> 230
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagtg ctcagggggc gtatggcaat     360
cagccccagc attttggtga tgggactcga ctctccatcc tagaggacct gaacaaggtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc ttccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacggacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaaccc gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt tacctcggtg tcctaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt cagcgccctt     900
gtgttgatgg ccatggtcaa gagaaaggat ttc                                  933

<210> 231
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta chain - Codon-Optimized, Cys Modified

<400> 231
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg cccagggcgc ctacggaaat     360
cagcctcagc actttggcga cggcacccgg ctgagcatcc tggaagatct gaacaaggtg     420
ttccccccag aggtggccgt gttcgagcct tctgaggccg agatctccca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt ttccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca ctccggcgtg tgcaccgatc cccagcctct gaaagaacag     600
cccgccctga acgacagccg gtactgcctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggacag agccaagccc gtgacacaga tcgtgtctgc cgaagcctgg     780
ggcagagccg attgcggctt tacctccgtg tcctatcagc agggcgtgct gagcgccaca     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtctgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac ttc                                  933

<210> 232
<211> 1848
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta-P2A-WT373 alpha Construct - WT

<400> 232
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagtg ctcagggggc gtatggcaat     360
cagccccagc attttggtga tgggactcga ctctccatcc tagaggacct gaacaaggtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc ttccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacggacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaaccc gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt tacctcggtg tcctaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt cagcgccctt     900
gtgttgatgg ccatggtcaa gagaaaggat ttcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggccatgct cctgggggca    1020
tcagtgctga ttctgtggct tcagccagac tgggtaaaca gtcaacagaa gaatgatgac    1080
cagcaagtta agcaaaattc accatccctg agcgtccagg aaggaagaat ttctattctg    1140
aactgtgact atactaacag catgtttgat tatttcctat ggtacaaaaa ataccctgct    1200
gaaggtccta cattcctgat atctataagt tccattaagg ataaaaatga agatggaaga    1260
ttcactgtct tcttaaacaa aagtgccaag cacctctctc tgcacattgt gccctcccag    1320
cctggagact ctgcagtgta cttctgtgca gcaggggctc ggggtggtac tagctatgga    1380
aagctgacat ttggacaagg gaccatcttg actgtccatc caaatatcca gaaccctgac    1440
cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc    1500
gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac    1560
aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc    1620
aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc    1680
ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca    1740
gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa    1800
gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                 1848

<210> 233
<211> 1848
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT373 beta-P2A-WT373 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 233
atgagcaacc aggtgctgtg ctgcgtggtg ctgtgtttcc tgggcgccaa cacagtggac      60
ggcggcatca cacagagccc caagtacctg ttccggaaag agggccagaa cgtgaccctg     120
agctgcgagc agaacctgaa ccacgacgcc atgtactggt acagacagga cccaggccag     180
ggcctgcggc tgatctacta cagccagatc gtgaacgact tccagaaggg cgacattgcc     240
gagggctaca gcgtgtccag agagaagaaa gagtccttcc cactgaccgt gaccagcgcc     300
cagaagaacc ccaccgcctt ctacctgtgt gccagctctg cccagggcgc ctacggaaat     360
cagcctcagc actttggcga cggcacccgg ctgagcatcc tggaagatct gaacaaggtg     420
ttccccccag aggtggccgt gttcgagcct tctgaggccg agatctccca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt ttccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca ctccggcgtg tgcaccgatc cccagcctct gaaagaacag     600
cccgccctga acgacagccg gtactgcctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggacag agccaagccc gtgacacaga tcgtgtctgc cgaagcctgg     780
ggcagagccg attgcggctt tacctccgtg tcctatcagc agggcgtgct gagcgccaca     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtctgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac ttcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggctatgct gctgggcgcc    1020
tctgtgctga tcctgtggct gcagcccgac tgggtcaaca gccagcagaa gaacgacgac    1080
cagcaagtga agcagaacag ccccagcctg agcgtgcagg aaggccggat cagcatcctg    1140
aactgcgact acaccaactc tatgttcgac tacttcctgt ggtacaagaa gtaccccgcc    1200
gagggcccca ccttcctgat ctccatcagc agcatcaagg acaagaacga ggacggccgg    1260
ttcaccgtgt ttctgaacaa gagcgccaag cacctgagcc tgcacatcgt gcctagccag    1320
cctggcgata gcgccgtgta cttttgtgcc gctggcgcta gaggcggcac cagctatggc    1380
aagctgacct ttggccaggg caccatcctg accgtgcacc ccaacatcca gaaccccgac    1440
cctgcagtgt accagctgcg ggacagcaag agcagcgaca agagcgtgtg cctgttcacc    1500
gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta catcaccgat    1560
aagtgcgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc    1620
aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcattatccc cgaggacaca    1680
ttcttcccaa gccccgagag cagctgcgac gtgaagctgg tggaaaagag cttcgagaca    1740
gacaccaacc tgaacttcca gaacctcagc gtgatcggct tccggatcct gctgctgaag    1800
gtggccggct tcaacctgct gatgaccctg cggctgtggt ccagctga                 1848

<210> 234
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain variable domain WT

<400> 234
atgctactca tcacatcaat gttggtctta tggatgcaat tgtcacaggt gaatggacaa      60
caggtaatgc aaattcctca gtaccagcat gtacaagaag gagaggactt caccacgtac     120
tgcaattcct caactacttt aagcaatata cagtggtata agcaaaggcc tggtggacat     180
cccgtttttt tgatacagtt agtgaagagt ggagaagtga agaagcagaa aagactgaca     240
tttcagtttg gagaagcaaa aaagaacagc tccctgcaca tcacagccac ccagactaca     300
gatgtaggaa cctacttctg tgcagggcgc acctcctacg acaaggtgat atttgggcca     360
gggacaagct tatcagtcat tccaaat                                         387

<210> 235
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain variable domain - Codon
      Optimized

<400> 235
atgctgctga tcacctccat gctggtgctg tggatgcagc tgagccaagt gaacggccag      60
caagtgatgc agatccccca gtaccagcac gtgcaggaag gcgaggactt caccacctac     120
tgcaacagca gcaccaccct gagcaacatc cagtggtaca agcagcggcc tggcggccac     180
cccgtgtttc tgatccagct cgtgaagtcc ggcgaagtga agaagcagaa gcggctgacc     240
ttccagttcg gcgaggccaa gaagaacagc agcctgcaca tcaccgccac ccagaccacc     300
gacgtgggca cctacttttg cgccggcaga accagctacg acaaagtgat cttcggccct     360
ggcaccagcc tgtccgtgat ccccaat                                         387

<210> 236
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain WT

<400> 236
atgctactca tcacatcaat gttggtctta tggatgcaat tgtcacaggt gaatggacaa      60
caggtaatgc aaattcctca gtaccagcat gtacaagaag gagaggactt caccacgtac     120
tgcaattcct caactacttt aagcaatata cagtggtata agcaaaggcc tggtggacat     180
cccgtttttt tgatacagtt agtgaagagt ggagaagtga agaagcagaa aagactgaca     240
tttcagtttg gagaagcaaa aaagaacagc tccctgcaca tcacagccac ccagactaca     300
gatgtaggaa cctacttctg tgcagggcgc acctcctacg acaaggtgat atttgggcca     360
gggacaagct tatcagtcat tccaaatatc cagaaccctg accctgccgt gtaccagctg     420
agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca     480
aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg     540
aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca     600
tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa     660
agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt     720
caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg     780
ctcatgacgc tgcggctgtg gtccagctga                                      810

<210> 237
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 alpha chain - Codon-Optimized, Cys Modified

<400> 237
atgctgctga tcacctccat gctggtgctg tggatgcagc tgagccaagt gaacggccag      60
caagtgatgc agatccccca gtaccagcac gtgcaggaag gcgaggactt caccacctac     120
tgcaacagca gcaccaccct gagcaacatc cagtggtaca agcagcggcc tggcggccac     180
cccgtgtttc tgatccagct cgtgaagtcc ggcgaagtga agaagcagaa gcggctgacc     240
ttccagttcg gcgaggccaa gaagaacagc agcctgcaca tcaccgccac ccagaccacc     300
gacgtgggca cctacttttg cgccggcaga accagctacg acaaagtgat cttcggccct     360
ggcaccagcc tgtccgtgat ccccaatatc cagaaccccg accccgcagt gtaccagctg     420
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc     480
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg     540
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc     600
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag     660
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc     720
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg     780
ctgatgaccc tgcggctgtg gtccagctga                                      810

<210> 238
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta chain variable domain WT

<400> 238
atggcctccc tgctcttctt ctgtggggcc ttttatctcc tgggaacagg gtccatggat      60
gctgatgtta cccagacccc aaggaatagg atcacaaaga caggaaagag gattatgctg     120
gaatgttctc agactaaggg tcatgataga atgtactggt atcgacaaga cccaggactg     180
ggcctacggt tgatctatta ctcctttgat gtcaaagata taaacaaagg agagatctct     240
gatggataca gtgtctctcg acaggcacag gctaaattct ccctgtccct agagtctgcc     300
atccccaacc agacagctct ttacttctgt gccaccagtg cagggacggt tggaaacacc     360
atatattttg gagagggaag ttggctcact gttgtagag                            399

<210> 239
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta chain variable domain - Codon Optimized

<400> 239
atggccagcc tgctgttctt ctgcggcgcc ttctacctgc tgggcaccgg ctctatggac      60
gccgatgtga cccagacccc ccggaacaga atcaccaaga ccggcaagcg gatcatgctg     120
gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga ccctggcctg     180
ggcctgcggc tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc     240
gacggctaca gcgtgtccag acaggctcag gccaagttca gcctgtccct ggaaagcgcc     300
atccccaacc agaccgccct gtacttctgt gccacaagcg ccggcaccgt gggcaacacc     360
atctactttg gcgagggcag ctggctgacc gtggtggaa                            399

<210> 240
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta chain WT

<400> 240
atggcctccc tgctcttctt ctgtggggcc ttttatctcc tgggaacagg gtccatggat      60
gctgatgtta cccagacccc aaggaatagg atcacaaaga caggaaagag gattatgctg     120
gaatgttctc agactaaggg tcatgataga atgtactggt atcgacaaga cccaggactg     180
ggcctacggt tgatctatta ctcctttgat gtcaaagata taaacaaagg agagatctct     240
gatggataca gtgtctctcg acaggcacag gctaaattct ccctgtccct agagtctgcc     300
atccccaacc agacagctct ttacttctgt gccaccagtg cagggacggt tggaaacacc     360
atatattttg gagagggaag ttggctcact gttgtagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttc                                         927

<210> 241
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta chain - Codon-Optimized, Cys Modified

<400> 241
atggccagcc tgctgttctt ctgcggcgcc ttctacctgc tgggcaccgg ctctatggac      60
gccgatgtga cccagacccc ccggaacaga atcaccaaga ccggcaagcg gatcatgctg     120
gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga ccctggcctg     180
ggcctgcggc tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc     240
gacggctaca gcgtgtccag acaggctcag gccaagttca gcctgtccct ggaaagcgcc     300
atccccaacc agaccgccct gtacttctgt gccacaagcg ccggcaccgt gggcaacacc     360
atctactttg gcgagggcag ctggctgacc gtggtggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttc                                         927

<210> 242
<211> 1803
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta-P2A-WT376 alpha Construct - WT

<400> 242
atggcctccc tgctcttctt ctgtggggcc ttttatctcc tgggaacagg gtccatggat      60
gctgatgtta cccagacccc aaggaatagg atcacaaaga caggaaagag gattatgctg     120
gaatgttctc agactaaggg tcatgataga atgtactggt atcgacaaga cccaggactg     180
ggcctacggt tgatctatta ctcctttgat gtcaaagata taaacaaagg agagatctct     240
gatggataca gtgtctctcg acaggcacag gctaaattct ccctgtccct agagtctgcc     300
atccccaacc agacagctct ttacttctgt gccaccagtg cagggacggt tggaaacacc     360
atatattttg gagagggaag ttggctcact gttgtagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgctac tcatcacatc aatgttggtc    1020
ttatggatgc aattgtcaca ggtgaatgga caacaggtaa tgcaaattcc tcagtaccag    1080
catgtacaag aaggagagga cttcaccacg tactgcaatt cctcaactac tttaagcaat    1140
atacagtggt ataagcaaag gcctggtgga catcccgttt ttttgataca gttagtgaag    1200
agtggagaag tgaagaagca gaaaagactg acatttcagt ttggagaagc aaaaaagaac    1260
agctccctgc acatcacagc cacccagact acagatgtag gaacctactt ctgtgcaggg    1320
cgcacctcct acgacaaggt gatatttggg ccagggacaa gcttatcagt cattccaaat    1380
atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct    1440
gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat    1500
gtgtatatca cagacaaaac tgtgctagac atgaggtcta tggacttcaa gagcaacagt    1560
gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt    1620
attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag    1680
aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga    1740
atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc    1800
tga                                                                  1803

<210> 243
<211> 1803
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT376 beta-P2A-WT376 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 243
atggccagcc tgctgttctt ctgcggcgcc ttctacctgc tgggcaccgg ctctatggac      60
gccgatgtga cccagacccc ccggaacaga atcaccaaga ccggcaagcg gatcatgctg     120
gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga ccctggcctg     180
ggcctgcggc tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc     240
gacggctaca gcgtgtccag acaggctcag gccaagttca gcctgtccct ggaaagcgcc     300
atccccaacc agaccgccct gtacttctgt gccacaagcg ccggcaccgt gggcaacacc     360
atctactttg gcgagggcag ctggctgacc gtggtggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgctgc tgatcacctc catgctggtg    1020
ctgtggatgc agctgagcca agtgaacggc cagcaagtga tgcagatccc ccagtaccag    1080
cacgtgcagg aaggcgagga cttcaccacc tactgcaaca gcagcaccac cctgagcaac    1140
atccagtggt acaagcagcg gcctggcggc caccccgtgt ttctgatcca gctcgtgaag    1200
tccggcgaag tgaagaagca gaagcggctg accttccagt tcggcgaggc caagaagaac    1260
agcagcctgc acatcaccgc cacccagacc accgacgtgg gcacctactt ttgcgccggc    1320
agaaccagct acgacaaagt gatcttcggc cctggcacca gcctgtccgt gatccccaat    1380
atccagaacc ccgaccccgc agtgtaccag ctgcgggaca gcaagagcag cgacaagagc    1440
gtgtgcctgt tcaccgactt cgacagccag accaacgtgt cccagagcaa ggacagcgac    1500
gtgtacatca ccgataagtg cgtgctggac atgcggagca tggacttcaa gagcaacagc    1560
gccgtggcct ggtccaacaa gagcgacttc gcctgcgcca acgccttcaa caacagcatt    1620
atccccgagg acacattctt cccaagcccc gagagcagct gcgacgtgaa gctggtggaa    1680
aagagcttcg agacagacac caacctgaac ttccagaacc tcagcgtgat cggcttccgg    1740
atcctgctgc tgaaggtggc cggcttcaac ctgctgatga ccctgcggct gtggtccagc    1800
tga                                                                  1803

<210> 244
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain variable domain WT

<400> 244
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt      60
gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact     120
ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc     180
agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca     240
gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc     300
gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tatcgggaaa cacacctctt     360
gtctttggaa agggcacaag actttctgtg attgcaaat                            399

<210> 245
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain variable domain - Codon
      Optimized

<400> 245
atgagcctga gcagcctgct gaaagtcgtg accgccagcc tgtggctggg acctggaatc      60
gcccagaaga tcacccagac ccagcccggc atgttcgtgc aggaaaaaga agccgtgacc     120
ctggactgca cctacgacac cagcgaccct agctacggcc tgttctggta caagcagccc     180
agcagcggcg agatgatctt cctgatctac cagggcagct acgaccagca gaacgccacc     240
gagggccggt acagcctgaa cttccagaag gcccggaagt ccgccaacct cgtgatcagc     300
gctagccagc tgggcgacag cgccatgtac ttttgcgcca tcagcggcaa cacccccctg     360
gtgtttggca agggcacccg gctgagcgtg atcgccaac                            399

<210> 246
<211> 822
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain WT

<400> 246
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt      60
gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact     120
ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc     180
agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca     240
gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc     300
gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tatcgggaaa cacacctctt     360
gtctttggaa agggcacaag actttctgtg attgcaaata tccagaaccc tgaccctgcc     420
gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt     480
gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaaaact     540
gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa     600
tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc     660
cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg     720
aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc     780
gggtttaatc tgctcatgac gctgcggctg tggtccagct ga                        822

<210> 247
<211> 822
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 alpha chain - Codon-Optimized, Cys Modified

<400> 247
atgagcctga gcagcctgct gaaagtcgtg accgccagcc tgtggctggg acctggaatc      60
gcccagaaga tcacccagac ccagcccggc atgttcgtgc aggaaaaaga agccgtgacc     120
ctggactgca cctacgacac cagcgaccct agctacggcc tgttctggta caagcagccc     180
agcagcggcg agatgatctt cctgatctac cagggcagct acgaccagca gaacgccacc     240
gagggccggt acagcctgaa cttccagaag gcccggaagt ccgccaacct cgtgatcagc     300
gctagccagc tgggcgacag cgccatgtac ttttgcgcca tcagcggcaa cacccccctg     360
gtgtttggca agggcacccg gctgagcgtg atcgccaaca tccagaaccc cgaccccgca     420
gtgtaccagc tgcgggacag caagagcagc gacaagagcg tgtgcctgtt caccgacttc     480
gacagccaga ccaacgtgtc ccagagcaag gacagcgacg tgtacatcac cgataagtgc     540
gtgctggaca tgcggagcat ggacttcaag agcaacagcg ccgtggcctg gtccaacaag     600
agcgacttcg cctgcgccaa cgccttcaac aacagcatta tccccgagga cacattcttc     660
ccaagccccg agagcagctg cgacgtgaag ctggtggaaa agagcttcga gacagacacc     720
aacctgaact tccagaacct cagcgtgatc ggcttccgga tcctgctgct gaaggtggcc     780
ggcttcaacc tgctgatgac cctgcggctg tggtccagct ga                        822

<210> 248
<211> 429
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta chain variable domain WT

<400> 248
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg      60
ctttgtctcc tgggagcagt ttcagtggct gctggagtca tccagtcccc aagacatctg     120
atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact     180
gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa     240
aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac     300
tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt     360
gccagcagct tgcgaggggg cctcgaaaaa ctgttttttg gcagtggaac ccagctctct     420
gtcttggag                                                             429

<210> 249
<211> 429
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta chain variable domain - Codon Optimized

<400> 249
atgctgagcc ccgatctgcc tgacagcgcc tggaacacca gactgctgtg ccacgtgatg      60
ctgtgcctgc tgggagccgt gtctgtggct gctggcgtga tccagagccc cagacacctg     120
atcaaagaga agagagagac agccaccctg aagtgctacc ccatccccag gcacgacacc     180
gtgtactggt atcagcaggg cccaggccag gacccccagt tcctgatcag cttctacgag     240
aagatgcaga gcgacaaggg cagcatcccc gacagattca gcgcccagca gttcagcgac     300
taccacagcg agctgaacat gagcagcctg gaactgggcg acagcgccct gtacttctgt     360
gccagctctc tgagaggcgg cctggaaaag ctgttcttcg gcagcggcac ccagctgagc     420
gtgctggaa                                                             429

<210> 250
<211> 957
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta chain WT

<400> 250
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg      60
ctttgtctcc tgggagcagt ttcagtggct gctggagtca tccagtcccc aagacatctg     120
atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact     180
gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa     240
aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac     300
tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt     360
gccagcagct tgcgaggggg cctcgaaaaa ctgttttttg gcagtggaac ccagctctct     420
gtcttggagg acctgaacaa ggtgttccca cccgaggtcg ctgtgtttga gccatcagaa     480
gcagagatct cccacaccca aaaggccaca ctggtgtgcc tggccacagg cttcttcccc     540
gaccacgtgg agctgagctg gtgggtgaat gggaaggagg tgcacagtgg ggtcagcacg     600
gacccgcagc ccctcaagga gcagcccgcc ctcaatgact ccagatactg cctgagcagc     660
cgcctgaggg tctcggccac cttctggcag aacccccgca accacttccg ctgtcaagtc     720
cagttctacg ggctctcgga gaatgacgag tggacccagg atagggccaa acccgtcacc     780
cagatcgtca gcgccgaggc ctggggtaga gcagactgtg gctttacctc ggtgtcctac     840
cagcaagggg tcctgtctgc caccatcctc tatgagatcc tgctagggaa ggccaccctg     900
tatgctgtgc tggtcagcgc ccttgtgttg atggccatgg tcaagagaaa ggatttc        957

<210> 251
<211> 957
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta chain - Codon-Optimized, Cys Modified

<400> 251
atgctgagcc ccgatctgcc tgacagcgcc tggaacacca gactgctgtg ccacgtgatg      60
ctgtgcctgc tgggagccgt gtctgtggct gctggcgtga tccagagccc cagacacctg     120
atcaaagaga agagagagac agccaccctg aagtgctacc ccatccccag gcacgacacc     180
gtgtactggt atcagcaggg cccaggccag gacccccagt tcctgatcag cttctacgag     240
aagatgcaga gcgacaaggg cagcatcccc gacagattca gcgcccagca gttcagcgac     300
taccacagcg agctgaacat gagcagcctg gaactgggcg acagcgccct gtacttctgt     360
gccagctctc tgagaggcgg cctggaaaag ctgttcttcg gcagcggcac ccagctgagc     420
gtgctggaag atctgaacaa ggtgttcccc ccagaggtgg ccgtgttcga gccttctgag     480
gccgagatct cccacaccca gaaagccacc ctcgtgtgcc tggccaccgg ctttttcccc     540
gaccacgtgg aactgtcttg gtgggtcaac ggcaaagagg tgcactccgg cgtgtgcacc     600
gatccccagc ctctgaaaga acagcccgcc ctgaacgaca gccggtactg cctgagcagc     660
agactgagag tgtccgccac cttctggcag aacccccgga accacttcag atgccaggtg     720
cagttctacg gcctgagcga gaacgacgag tggacccagg acagagccaa gcccgtgaca     780
cagatcgtgt ctgccgaagc ctggggcaga gccgattgcg gctttacctc cgtgtcctat     840
cagcagggcg tgctgagcgc cacaatcctg tacgagatcc tgctgggcaa ggccaccctg     900
tacgccgtgc tggtgtctgc cctggtgctg atggccatgg tcaagcggaa ggacttc        957

<210> 252
<211> 1845
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta-P2A-WT377 alpha Construct - WT

<400> 252
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg      60
ctttgtctcc tgggagcagt ttcagtggct gctggagtca tccagtcccc aagacatctg     120
atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact     180
gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa     240
aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac     300
tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt     360
gccagcagct tgcgaggggg cctcgaaaaa ctgttttttg gcagtggaac ccagctctct     420
gtcttggagg acctgaacaa ggtgttccca cccgaggtcg ctgtgtttga gccatcagaa     480
gcagagatct cccacaccca aaaggccaca ctggtgtgcc tggccacagg cttcttcccc     540
gaccacgtgg agctgagctg gtgggtgaat gggaaggagg tgcacagtgg ggtcagcacg     600
gacccgcagc ccctcaagga gcagcccgcc ctcaatgact ccagatactg cctgagcagc     660
cgcctgaggg tctcggccac cttctggcag aacccccgca accacttccg ctgtcaagtc     720
cagttctacg ggctctcgga gaatgacgag tggacccagg atagggccaa acccgtcacc     780
cagatcgtca gcgccgaggc ctggggtaga gcagactgtg gctttacctc ggtgtcctac     840
cagcaagggg tcctgtctgc caccatcctc tatgagatcc tgctagggaa ggccaccctg     900
tatgctgtgc tggtcagcgc ccttgtgttg atggccatgg tcaagagaaa ggatttcggt     960
tccggagcca cgaacttctc tctgttaaag caagcaggag acgtggaaga aaaccccggt    1020
cccatgtcac tttctagcct gctgaaggtg gtcacagctt cactgtggct aggacctggc    1080
attgcccaga agataactca aacccaacca ggaatgttcg tgcaggaaaa ggaggctgtg    1140
actctggact gcacatatga caccagtgat ccaagttatg gtctattctg gtacaagcag    1200
cccagcagtg gggaaatgat ttttcttatt tatcaggggt cttatgacca gcaaaatgca    1260
acagaaggtc gctactcatt gaatttccag aaggcaagaa aatccgccaa ccttgtcatc    1320
tccgcttcac aactggggga ctcagcaatg tacttctgtg caatatcggg aaacacacct    1380
cttgtctttg gaaagggcac aagactttct gtgattgcaa atatccagaa ccctgaccct    1440
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat    1500
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa    1560
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac    1620
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc    1680
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat    1740
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg    1800
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                    1845

<210> 253
<211> 1845
<212> DNA
<213> Artificial Sequence

<220> 
<223> WT377 beta-P2A-WT377 alpha Construct -
      Codon-Optimized, Cys Modified

<400> 253
atgctgagcc ccgatctgcc tgacagcgcc tggaacacca gactgctgtg ccacgtgatg      60
ctgtgcctgc tgggagccgt gtctgtggct gctggcgtga tccagagccc cagacacctg     120
atcaaagaga agagagagac agccaccctg aagtgctacc ccatccccag gcacgacacc     180
gtgtactggt atcagcaggg cccaggccag gacccccagt tcctgatcag cttctacgag     240
aagatgcaga gcgacaaggg cagcatcccc gacagattca gcgcccagca gttcagcgac     300
taccacagcg agctgaacat gagcagcctg gaactgggcg acagcgccct gtacttctgt     360
gccagctctc tgagaggcgg cctggaaaag ctgttcttcg gcagcggcac ccagctgagc     420
gtgctggaag atctgaacaa ggtgttcccc ccagaggtgg ccgtgttcga gccttctgag     480
gccgagatct cccacaccca gaaagccacc ctcgtgtgcc tggccaccgg ctttttcccc     540
gaccacgtgg aactgtcttg gtgggtcaac ggcaaagagg tgcactccgg cgtgtgcacc     600
gatccccagc ctctgaaaga acagcccgcc ctgaacgaca gccggtactg cctgagcagc     660
agactgagag tgtccgccac cttctggcag aacccccgga accacttcag atgccaggtg     720
cagttctacg gcctgagcga gaacgacgag tggacccagg acagagccaa gcccgtgaca     780
cagatcgtgt ctgccgaagc ctggggcaga gccgattgcg gctttacctc cgtgtcctat     840
cagcagggcg tgctgagcgc cacaatcctg tacgagatcc tgctgggcaa ggccaccctg     900
tacgccgtgc tggtgtctgc cctggtgctg atggccatgg tcaagcggaa ggacttcggt     960
tccggagcca cgaacttctc tctgttaaag caagcaggag acgtggaaga aaaccccggt    1020
cccatgagcc tgagcagcct gctgaaagtc gtgaccgcca gcctgtggct gggacctgga    1080
atcgcccaga agatcaccca gacccagccc ggcatgttcg tgcaggaaaa agaagccgtg    1140
accctggact gcacctacga caccagcgac cctagctacg gcctgttctg gtacaagcag    1200
cccagcagcg gcgagatgat cttcctgatc taccagggca gctacgacca gcagaacgcc    1260
accgagggcc ggtacagcct gaacttccag aaggcccgga agtccgccaa cctcgtgatc    1320
agcgctagcc agctgggcga cagcgccatg tacttttgcg ccatcagcgg caacaccccc    1380
ctggtgtttg gcaagggcac ccggctgagc gtgatcgcca acatccagaa ccccgacccc    1440
gcagtgtacc agctgcggga cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac    1500
ttcgacagcc agaccaacgt gtcccagagc aaggacagcg acgtgtacat caccgataag    1560
tgcgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac    1620
aagagcgact tcgcctgcgc caacgccttc aacaacagca ttatccccga ggacacattc    1680
ttcccaagcc ccgagagcag ctgcgacgtg aagctggtgg aaaagagctt cgagacagac    1740
accaacctga acttccagaa cctcagcgtg atcggcttcc ggatcctgct gctgaaggtg    1800
gccggcttca acctgctgat gaccctgcgg ctgtggtcca gctga                    1845

<210> 254
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide

<400> 254
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct      60
ggacct                                                                 66

<210> 255
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide - Codon
      Optimized

<400> 255
ggttccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga agaaaacccc      60
ggtccc                                                                 66

<210> 256
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Thoseaasigna virus 2A (T2A) peptide

<400> 256
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga      60
cct                                                                    63

<210> 257
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> Equine rhinitis A virus (ERAV) 2A (E2A) peptide

<400> 257
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac      60
cctggacct                                                              69

<210> 258
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> Foot-and-Mouth disease virus 2A (F2A) peptide

<400> 258
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag      60
tccaaccctg gacct                                                       75
