                         SEQUENCE LISTING

<110>  The Trustees of The University of Pennsylvania
       Powell, Daniel
       Tsourkas, Andrew
 
<120>  SPYCATCHER AND SPYTAG: UNIVERSAL IMMUNE RECEPTORS FOR T CELLS

<130>  046483-7094WO1(01238)

<150>  US 62/271,071
<151>  2015-12-22

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  1
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagaa tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac      840

gccgccaggc cgggatccgc ccacattgtg atggtggacg cctacaagcc caccaaggct      900

agcaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      960

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1020

ctggacttcg cctgtgattt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat     1080

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc     1140

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1200

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccatcgatag agtgaagttc     1260

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1320

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1380

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1440

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1500

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1560

cacatgcagg ccctgccccc tcgctaa                                         1587


<210>  2
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  2

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Arg Met Ala Leu Pro Val Thr Ala Leu Leu 
            260                 265                 270         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Ala His 
        275                 280                 285             


Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Ala Ser Thr Thr Thr 
    290                 295                 300                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
305                 310                 315                 320 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                325                 330                 335     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
            340                 345                 350         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        355                 360                 365             


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
    370                 375                 380                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
385                 390                 395                 400 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  3
<211>  1650
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  3
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagaa tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac      840

gccgccaggc cgggatccgc ccacatcgtg atggtggacg cctacaagcc caccaagggc      900

ggcagcggcg gcagcggcgg cagcggcggc agcggcggca gcggcggcag cggcggcagc      960

gctagcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     1020

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     1080

gggctggact tcgcctgtga tttttgggtg ctggtggtgg ttggtggagt cctggcttgc     1140

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg     1200

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1260

taccagccct atgccccacc acgcgacttc gcagcctatc gctccatcga tagagtgaag     1320

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1380

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1440

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1500

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1560

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1620

cttcacatgc aggccctgcc ccctcgctaa                                      1650


<210>  4
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  4

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Arg Met Ala Leu Pro Val Thr Ala Leu Leu 
            260                 265                 270         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Ala His 
        275                 280                 285             


Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly Ser Gly Gly 
    290                 295                 300                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
305                 310                 315                 320 


Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                325                 330                 335     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            340                 345                 350         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        355                 360                 365             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    370                 375                 380                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
385                 390                 395                 400 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                405                 410                 415     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            420                 425                 430         


Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        435                 440                 445             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    450                 455                 460                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
465                 470                 475                 480 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                485                 490                 495     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            500                 505                 510         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        515                 520                 525             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    530                 535                 540                 


Ala Leu Pro Pro Arg 
545                 


<210>  5
<211>  1017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  5
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg gaagcggaga tagcgccacc cacatcaagt tcagcaagcg ggacgaggac      120

ggcaaagagc tggctggcgc caccatggaa ctgcgggata gcagcggcaa gaccatcagc      180

acctggatca gcgacggcca ggtcaaagac ttctacctgt accccggcaa gtacaccttc      240

gtggaaacag ccgcccctga cggctatgag gtggccacag ccatcacctt caccgtgaac      300

gagcagggac aggtcacagt gaacggcgct agcaccacga cgccagcgcc gcgaccacca      360

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      420

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgattt ttgggtgctg      480

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      540

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc      600

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca      660

gcctatcgct ccatcgatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      720

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      780

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct      840

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt      900

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt      960

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1017


<210>  6
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Ser Gly Asp Ser Ala Thr His Ile 
            20                  25                  30          


Lys Phe Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr 
        35                  40                  45              


Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser 
    50                  55                  60                  


Asp Gly Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe 
65                  70                  75                  80  


Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr 
                85                  90                  95      


Phe Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Ala Ser Thr 
            100                 105                 110         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        115                 120                 125             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    130                 135                 140                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
145                 150                 155                 160 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                165                 170                 175     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            180                 185                 190         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        195                 200                 205             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220                 


Ile Asp Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
225                 230                 235                 240 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                245                 250                 255     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            260                 265                 270         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        275                 280                 285             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    290                 295                 300                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
305                 310                 315                 320 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                325                 330                 335     


Pro Arg 
        


<210>  7
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  7
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg gaagcggcga tagcgccacc cacatcaagt tcagcaagcg ggacgaggac      120

ggcaaagagc tggctggcgc caccatggaa ctgcgggaca gcagcggcaa gaccatcagc      180

acctggatca gcgacggcca ggtcaaagac ttctacctgt accccggcaa gtacaccttc      240

gtggaaacag ccgcccctga cggctacgag gtggccacag ccatcacctt caccgtgaac      300

gagcagggac aggtcacagt gaacggcggc ggcagcggcg gcagcggcgg cagcggcggc      360

agcggcggca gcggcggcag cggcggcagc gctagcacca cgacgccagc gccgcgacca      420

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      480

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tttttgggtg      540

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt      600

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact      660

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc      720

gcagcctatc gctccatcga tagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      780

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      840

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      900

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag      960

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1020

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1080


<210>  8
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gly Ser Gly Asp Ser Ala Thr His Ile 
            20                  25                  30          


Lys Phe Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr 
        35                  40                  45              


Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser 
    50                  55                  60                  


Asp Gly Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe 
65                  70                  75                  80  


Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr 
                85                  90                  95      


Phe Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    130                 135                 140                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
145                 150                 155                 160 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                165                 170                 175     


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            180                 185                 190         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        195                 200                 205             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    210                 215                 220                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
225                 230                 235                 240 


Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg Ser Ala Asp 
                245                 250                 255     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            260                 265                 270         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        275                 280                 285             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    290                 295                 300                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
305                 310                 315                 320 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                325                 330                 335     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            340                 345                 350         


Met Gln Ala Leu Pro Pro Arg 
        355                 


<210>  9
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg cccacattgt gatggtggac gcctacaagc ccaccaaggc tagcaccacg      120

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      180

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      240

gcctgtgatt tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      300

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt      360

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      420

gccccaccac gcgacttcgc agcctatcgc tccatcgata gagtgaagtt cagcaggagc      480

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga      540

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga      600

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg      660

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat      720

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag      780

gccctgcccc ctcgctaa                                                    798


<210>  10
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ala His Ile Val Met Val Asp Ala Tyr 
            20                  25                  30          


Lys Pro Thr Lys Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        35                  40                  45              


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    50                  55                  60                  


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
65                  70                  75                  80  


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                85                  90                  95      


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
            100                 105                 110         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        115                 120                 125             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    130                 135                 140                 


Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg Ser 
145                 150                 155                 160 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                165                 170                 175     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            180                 185                 190         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        195                 200                 205             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    210                 215                 220                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
225                 230                 235                 240 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                245                 250                 255     


Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265 


<210>  11
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  11
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg cccacatcgt gatggtggac gcctacaagc ccaccaaggg cggcagcggc      120

ggcagcggcg gcagcggcgg cagcggcggc agcggcggca gcggcggcag cgctagcacc      180

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      240

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      300

ttcgcctgtg atttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      360

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      420

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      480

tatgccccac cacgcgactt cgcagcctat cgctccatcg atagagtgaa gttcagcagg      540

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta      600

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      660

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      720

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac      780

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg      840

caggccctgc cccctcgcta a                                                861


<210>  12
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ala His Ile Val Met Val Asp Ala Tyr 
            20                  25                  30          


Lys Pro Thr Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala Ser Thr Thr Thr Pro Ala 
    50                  55                  60                  


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
65                  70                  75                  80  


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                85                  90                  95      


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
            100                 105                 110         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        115                 120                 125             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    130                 135                 140                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
145                 150                 155                 160 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val 
                165                 170                 175     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            180                 185                 190         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    210                 215                 220                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
225                 230                 235                 240 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                245                 250                 255     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            260                 265                 270         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 285     


<210>  13
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  13
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagaa tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac      840

gccgccaggc cgggatccgg aagcggagat agcgccaccc acatcaagtt cagcaagcgg      900

gacgaggacg gcaaagagct ggctggcgcc accatggaac tgcgggatag cagcggcaag      960

accatcagca cctggatcag cgacggccag gtcaaagact tctacctgta ccccggcaag     1020

tacaccttcg tggaaacagc cgcccctgac ggctatgagg tggccacagc catcaccttc     1080

accgtgaacg agcagggaca ggtcacagtg aacggcgcta gcaccacgac gccagcgccg     1140

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1200

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatttt     1260

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1320

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1380

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1440

gacttcgcag cctatcgctc catcgataga gtgaagttca gcaggagcgc agacgccccc     1500

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1560

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1620

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1680

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1740

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1800

cgctaa                                                                1806


<210>  14
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  14

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Arg Met Ala Leu Pro Val Thr Ala Leu Leu 
            260                 265                 270         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Gly Ser 
        275                 280                 285             


Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly 
    290                 295                 300                 


Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys 
305                 310                 315                 320 


Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu 
                325                 330                 335     


Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr 
            340                 345                 350         


Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val 
        355                 360                 365             


Thr Val Asn Gly Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    370                 375                 380                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
385                 390                 395                 400 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                405                 410                 415     


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg Ser 
                485                 490                 495     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            500                 505                 510         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        515                 520                 525             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    530                 535                 540                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
545                 550                 555                 560 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                565                 570                 575     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            580                 585                 590         


Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600     


<210>  15
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  15
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagaa tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac      840

gccgccaggc cgggatccgg aagcggcgat agcgccaccc acatcaagtt cagcaagcgg      900

gacgaggacg gcaaagagct ggctggcgcc accatggaac tgcgggacag cagcggcaag      960

accatcagca cctggatcag cgacggccag gtcaaagact tctacctgta ccccggcaag     1020

tacaccttcg tggaaacagc cgcccctgac ggctacgagg tggccacagc catcaccttc     1080

accgtgaacg agcagggaca ggtcacagtg aacggcggcg gcagcggcgg cagcggcggc     1140

agcggcggca gcggcggcag cggcggcagc ggcggcagcg ctagcaccac gacgccagcg     1200

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag     1260

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat     1320

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1380

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1440

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1500

cgcgacttcg cagcctatcg ctccatcgat agagtgaagt tcagcaggag cgcagacgcc     1560

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1620

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1680

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1740

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1800

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1860

cctcgctaa                                                             1869


<210>  16
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially Synthesized

<400>  16

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Arg Met Ala Leu Pro Val Thr Ala Leu Leu 
            260                 265                 270         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Gly Ser 
        275                 280                 285             


Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly 
    290                 295                 300                 


Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys 
305                 310                 315                 320 


Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu 
                325                 330                 335     


Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr 
            340                 345                 350         


Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val 
        355                 360                 365             


Thr Val Asn Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala Ser Thr Thr Thr Pro Ala 
385                 390                 395                 400 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
                405                 410                 415     


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
            420                 425                 430         


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
        435                 440                 445             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    450                 455                 460                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
465                 470                 475                 480 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                485                 490                 495     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val 
            500                 505                 510         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        515                 520                 525             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    530                 535                 540                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
545                 550                 555                 560 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                565                 570                 575     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            580                 585                 590         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        595                 600                 605             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620         


