                         SEQUENCE LISTING

<110>  McLeod, Rima
       McPhillie, Martin
       Fishwick, Colin W.G.
       Lorenzi, Hernan Alejandro
       Wang, Kai
       Kim, Taekkyun
       Zhou, Yong
       Hood, Leory E.
       Zhou, Ying
 
<120>  Compounds and Methods for Treating, Detecting, and Identifying 
       Compounds to Treat Apicomplexan Parasitic Diseases

<130>  15-2033-PCT

<150>  62/270264
<151>  2015-12-21

<150>  62/306385
<151>  2016-03-10

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Gly Asn Arg Pro His Tyr His Val Ala Lys Gln Glu Trp Arg Val 
1               5                   10                  15      


Arg Tyr Tyr Met Asn Gly Lys Arg Lys Met Arg Thr Tyr Ser Ala Lys 
            20                  25                  30          


Phe Tyr Gly Tyr Glu Thr Ala His Thr Met Ala Glu Asp Phe Ala His 
        35                  40                  45              


Tyr Val Asp Lys His Glu 
    50                  


<210>  2
<211>  2406
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Pro Ala Pro Ser Ala Glu Ala Arg Pro Ala Lys Arg Arg 
1               5                   10                  15      


Cys Phe Pro Leu Pro Arg Glu Thr Pro Val Ser Ser Glu Asp Glu Thr 
            20                  25                  30          


Arg Lys Thr Leu Gln His Asp Thr Leu Gly Cys Leu Pro Arg Ser Ser 
        35                  40                  45              


Ser Gly Gln Pro Glu Leu Ala Ala Ala Ser Ala Ala Ser Gln Val Gly 
    50                  55                  60                  


His Leu Ser Ser Ala Ala Leu Leu Gln Leu Val Gln Thr Gln Ser Ala 
65                  70                  75                  80  


Gly Gly Val Pro Gln Ala Val Leu Arg Asn Leu Phe Ser Ser Ile His 
                85                  90                  95      


Arg Asn Pro Lys Pro Leu Pro Ala Asn Ala Leu Ala Ala Thr Pro Asn 
            100                 105                 110         


Ser Ser Leu Tyr Ala Ser Leu Thr Ser Leu Ser Ser Ala Ala Ala Leu 
        115                 120                 125             


Pro Gly Ala Gly Pro Ala Tyr Ser Gln Ala Pro Ser Pro Ala Ser Ala 
    130                 135                 140                 


Asp Leu Leu Gln Ser Glu Gln Phe Gly Ser Ala Ala Lys Asn Pro Ser 
145                 150                 155                 160 


Pro Asn Glu Ala Ser Pro Ile Leu Ala Leu Leu Gly Glu Ala Ala Arg 
                165                 170                 175     


Ala Ala Thr Thr Pro Arg Thr Val Pro Ala Leu Ser Ala Val Cys Pro 
            180                 185                 190         


Ala Ala Ser Ser Gly Val Ser Leu Pro Ser Ala Ser Asp Thr Leu Ala 
        195                 200                 205             


Leu Ala Gln Ser Ser Leu Ser Ser Ser Thr Gly Cys Ala Ser Asp Val 
    210                 215                 220                 


Lys Ala Ser Arg Pro Glu Glu His Pro Ala Phe Ala Ser Gly Thr Ala 
225                 230                 235                 240 


Asn Arg Gln Ser Leu Leu Gln Ala Leu Leu Leu Ser Thr Ala Pro Leu 
                245                 250                 255     


Ala Phe Ser Gly Pro Ser Leu Ser Ser Ala Ser Thr Thr Leu Pro Ala 
            260                 265                 270         


Ser Ser Gly Ala Val Ser Ser Arg Asn Ala Gly Ala Tyr Gln Phe Glu 
        275                 280                 285             


Arg Leu Leu Gln Ala Glu Ala Ala Lys Val Lys Ala Leu Leu Pro Asn 
    290                 295                 300                 


Ala Thr Ser Lys Ser Met Ser Gln Ser Ser Val Pro Gln Arg Asp Leu 
305                 310                 315                 320 


Thr Arg Lys Thr Ser Leu Phe Pro Asp Pro Arg Gly Leu Ser Ala Asp 
                325                 330                 335     


Asp Ala Ser Arg Arg Tyr Asn Thr Arg Gly Ala Asn Ser Gly Gly Ala 
            340                 345                 350         


Gly Leu Arg Arg Gly Thr Gly Val His Ala Thr Thr Glu Gln Ser Gly 
        355                 360                 365             


Ala Leu Asp Ala Gly Glu Arg Thr Arg Pro Phe Gly Ala Gly Glu Asp 
    370                 375                 380                 


Glu Ser Ala Gln Gly Lys Pro Asp Ser Arg Gly Arg Gln Arg Pro Gly 
385                 390                 395                 400 


Ala Leu Asp Ala Ser Asn Ile Leu Gly Leu Leu Ala Ala Phe Gln Pro 
                405                 410                 415     


Ser Gln Ala Pro Ala Ile Arg Asp Leu Ser Ala Pro Ser His Leu Ser 
            420                 425                 430         


Ala Ala Ala Thr Gly Ala Leu Pro Leu Thr Ala Ser Phe Thr Ala Ser 
        435                 440                 445             


Ala Leu Ala Ser Ser Gln Cys Leu Pro Ala Gly Thr Pro Ala Ser Ser 
    450                 455                 460                 


Ser Ala Ser Pro Pro Phe Ser Glu Val Leu Ser Thr Thr Glu Glu Ser 
465                 470                 475                 480 


Ser Thr Thr Lys Glu Thr Asp Ala Ser Ala Ser Thr Leu Leu Ala Phe 
                485                 490                 495     


Leu Gln Lys Tyr Ser Ala Val Ser Gly Leu Gly Gly Ala Ser Asp Phe 
            500                 505                 510         


Leu Gly Gln Leu Gln Gly Lys Ser Ser Leu Pro Pro Leu Ser Leu Ala 
        515                 520                 525             


Glu Pro Ser Ser Ala Leu Pro Ser Ser Phe Leu Gly Gly Ser Asp Gly 
    530                 535                 540                 


Gly Thr Ile Asp Thr Arg Asn Gly Asn Gly Glu Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Ile His Leu Phe Gln Ser Ala Phe Arg Ile Pro Ser Pro Ser Gln Gln 
                565                 570                 575     


Asn Leu Leu Asp Ala Leu Leu Ala Ser Ser Cys Thr Thr Ala Thr Ser 
            580                 585                 590         


Arg Ser Asp Gly Ser Gly Asn Leu Gly Cys Pro Val Val Asp Glu Arg 
        595                 600                 605             


Asn Ala Lys Leu Ala Gly Pro Ala His Pro Leu Pro Cys Ser Phe Pro 
    610                 615                 620                 


Gln Ile Ser Ser Ser Ser Gly Glu Pro Gly Arg Lys Thr Gly Gly Arg 
625                 630                 635                 640 


Val His Arg Gln Gly Thr Ser Gln Ser Gly Gly Arg Val Arg Ser Gly 
                645                 650                 655     


Lys Asn Gly Gly Ser Ala Ala Pro Pro Arg Gln Ser Ser Ser Glu Asn 
            660                 665                 670         


Val Pro Ser Thr Pro Thr Val Ser Ser His Glu Ala Pro His Arg Ala 
        675                 680                 685             


Gly Phe Pro Ser Gln Thr Pro Tyr Glu Leu Ser Ala Ser Pro Ser His 
    690                 695                 700                 


Gln Leu Asp Leu Leu Arg Leu Gly Ala Phe Leu Gly Gly Ala Gly Lys 
705                 710                 715                 720 


Gln Asp Ala Ser Val His Ser Asp Glu Thr Gly Thr Leu Ser Gly Glu 
                725                 730                 735     


Pro Ser His Arg Ser Cys Ser Leu Ser Arg Gly Leu Thr Gln Glu Ser 
            740                 745                 750         


Val Leu Gln Leu Ser Asp Thr Thr Ser Thr Ser Arg Glu Gly Glu Pro 
        755                 760                 765             


Asn Glu Pro Ser Gln Gly Cys Val Asn Val Ala Ala Ser Leu Pro Ala 
    770                 775                 780                 


Phe Gly Pro Gln Pro Ser Ser Gly Ala Ala Lys Ala Arg Glu Gly Arg 
785                 790                 795                 800 


Arg Gly Ala Gly Gly Ala Gly Ala Ala Pro Pro Val Pro Leu Arg Ala 
                805                 810                 815     


Asp Val Thr Leu Gly Gly Asn Arg Pro His Tyr His Val Ala Lys Gln 
            820                 825                 830         


Glu Trp Arg Val Arg Tyr Tyr Met Asn Gly Lys Arg Lys Met Arg Thr 
        835                 840                 845             


Tyr Ser Ala Lys Phe Tyr Gly Tyr Glu Thr Ala His Thr Met Ala Glu 
    850                 855                 860                 


Asp Phe Ala His Tyr Val Asp Lys His Glu Ala Leu Pro Asp Ser Met 
865                 870                 875                 880 


Met Met Thr Ala Met Met Leu Gln Ala Gln Ala Asn Ser Ala Ala Ser 
                885                 890                 895     


Ser Gly Gln Thr Val Pro Leu Ala Arg Gly Ile Arg Ala Ser Ser Ala 
            900                 905                 910         


Ser Ala Gly Ala Gly Gly His Val Ser Lys Ser Ala Thr Lys Gly Ser 
        915                 920                 925             


Val Ala Ala Ser Ser Glu Gly Ser Thr Ser Met Gly Ser Asp Ala Thr 
    930                 935                 940                 


Arg Ser Gln Glu Gly Glu Ala Ala Glu Leu Cys Pro Leu Ala Ala Gly 
945                 950                 955                 960 


Leu Ser Arg Pro Leu Ala Ser Met His Ser Ala Ala Gly Asn Ala Val 
                965                 970                 975     


Ala Gln Gly Arg Gln Glu Ser Lys Glu Glu Ala Pro Gly Gly Gln Ala 
            980                 985                 990         


Trp Phe Gly Glu Pro Gly Lys Phe  Arg Ala Ser Ser Glu  Ala Ala Leu 
        995                 1000                 1005             


Cys Gly  Ser Gly Ser Ser Ala  Glu Gly Arg Asp Gly  His Glu Ser 
    1010                 1015                 1020             


Glu Val  Leu Trp Ala Thr Leu  Gly Lys Val His Asp  Ala Ser Gln 
    1025                 1030                 1035             


Gly Lys  Lys Ile Lys Pro Glu  Lys Pro Leu Thr Val  Ala Arg Gly 
    1040                 1045                 1050             


Arg Leu  Ala Leu Gly Ala Glu  Asp Lys Ser Gln Asn  Leu Gly Val 
    1055                 1060                 1065             


Asp Leu  Gly Asp Ser Gly Gly  Ala Gln Gly Leu Pro  Gly Val Arg 
    1070                 1075                 1080             


Gln Pro  Arg Gln Met Lys Asn  Ser Glu Glu Cys Ser  Leu Arg Asp 
    1085                 1090                 1095             


Ser Asp  Lys Gly Met Ala Leu  Ser Lys Arg Phe Gly  Phe Leu Pro 
    1100                 1105                 1110             


Ser Gln  Thr Pro Ser Cys Asp  Ser Met Thr Leu Pro  Phe Pro Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ala Leu Ser Leu  Ser Ser Ala Leu Ser  Ser Cys Ala 
    1130                 1135                 1140             


Ser Leu  Pro Val Ala His Glu  Gly Asn Asn Phe Gln  Lys Gly His 
    1145                 1150                 1155             


Thr Gly  Asp Ile Val Ala Leu  Ala Ser Gln Ser Gly  Thr Gln Arg 
    1160                 1165                 1170             


Pro Ala  Ser Val Val Leu Ser  Arg Asp Ala Asn Val  Ser Gly Ser 
    1175                 1180                 1185             


Ser Pro  Ser His Pro Thr Trp  Gln Arg Glu Gly Ala  Ala Val Ser 
    1190                 1195                 1200             


Gly Arg  Ala Asp Glu Phe Ser  Ser Leu Ser Val Thr  Pro Ser Thr 
    1205                 1210                 1215             


Val Pro  Leu Ser Ser Phe Thr  Met Glu Asp Ile Lys  Gly Glu Glu 
    1220                 1225                 1230             


Gly Asp  Pro Ser Arg Arg Phe  Ala Leu Val Gly Glu  Ser Met Lys 
    1235                 1240                 1245             


Asn Val  Ser Ala Pro Glu Val  Gln Ala Leu Phe Pro  Thr Ser Ser 
    1250                 1255                 1260             


Ile Ala  Asn Ala Glu Leu Leu  Pro Val Asp Phe Leu  His Ser Asn 
    1265                 1270                 1275             


Ser Cys  Ser Ala Asp Lys Leu  Glu Ser Ser Ile Pro  Arg Gly Leu 
    1280                 1285                 1290             


Ala Gly  Asn Asn Pro Ser Met  Thr Ala Thr Ala Val  Ala Ala Thr 
    1295                 1300                 1305             


Ala Val  Ser His Gln Ile Phe  Asp Thr Ile Thr Leu  Phe Gly Glu 
    1310                 1315                 1320             


Phe Leu  Arg Glu Phe Ala Lys  Glu Lys Val Asn Glu  Phe His Glu 
    1325                 1330                 1335             


Tyr Gly  Leu Glu Ala Ser Pro  Leu Thr Val Glu Ala  Ser Pro Glu 
    1340                 1345                 1350             


Val Ser  Leu Phe Gly Lys Ala  Thr Phe Gly Arg Cys  Pro Val Ala 
    1355                 1360                 1365             


Gly Gly  Ser Thr Pro Ala Gly  Ile Ser Lys Met Ser  Gly Glu Thr 
    1370                 1375                 1380             


Leu Ser  Gly Leu Ser Ala Ser  Glu Leu Ser Leu Val  Ser Ala Arg 
    1385                 1390                 1395             


Thr Asn  Thr Thr Thr Gly Glu  Glu Gln Phe Ala Leu  Ala Arg Gly 
    1400                 1405                 1410             


Leu Phe  Pro Gly Asp Ser Glu  Gly Asp Arg Asp Glu  Lys Lys Pro 
    1415                 1420                 1425             


Gln Leu  Ser Gln Gln Glu Leu  Leu Val Leu Ser His  Ala Leu Val 
    1430                 1435                 1440             


Asn Leu  Thr Ser Ser Thr Tyr  Val Leu Met His Thr  Leu Lys Ala 
    1445                 1450                 1455             


Ser Leu  Ser Lys Ser Thr Glu  Ala Val Gln Leu His  Gln Pro Leu 
    1460                 1465                 1470             


Leu Glu  Ala Ala Ser Glu Ala  Lys Ala Thr Asp Glu  Ala Lys Thr 
    1475                 1480                 1485             


Arg Glu  Glu Gln Glu Ser Ser  Glu Cys Asp His Glu  Tyr Pro Pro 
    1490                 1495                 1500             


Gly Ser  Ser Leu Glu Ala Thr  Thr Gly Ala Leu Pro  Phe Arg Leu 
    1505                 1510                 1515             


Ser Pro  Ala Leu Ser Ala Ser  Ser Lys Asp Leu Pro  Ser Leu Ser 
    1520                 1525                 1530             


Ala Ser  Ala Ser Leu Glu Ser  Val Thr Pro Phe Ala  Gly Leu Pro 
    1535                 1540                 1545             


Leu Glu  Glu Gly Thr Leu Ser  Ala Ser Val Gly Leu  Ala Ser Ser 
    1550                 1555                 1560             


Asp Asp  Glu His Asp Thr Ser  Leu Leu Phe Lys Thr  Glu Ala Ala 
    1565                 1570                 1575             


Lys Lys  Arg Ser Leu Phe Ser  Thr Ala Ala Asp Gly  Asp Glu Ser 
    1580                 1585                 1590             


Arg Thr  Tyr Asn Asp Gly Leu  Gly Gln Pro Met Glu  Glu Glu Ile 
    1595                 1600                 1605             


Arg Ser  Cys Val Ser Thr Ser  Cys Gly Glu Ala Val  Ala Thr Thr 
    1610                 1615                 1620             


Thr Leu  Ser Ala Ile Gly Pro  Gly Thr Gly Ala Ser  Gly Ala Leu 
    1625                 1630                 1635             


Leu Asp  Ser Glu Ser Arg Glu  Ser Leu Gly Glu Lys  Pro Gly Ala 
    1640                 1645                 1650             


Ala Leu  Arg Ala Gly Ala His  Thr Pro Ala Pro Ser  Arg Ala Pro 
    1655                 1660                 1665             


Thr Pro  Ser Arg Thr Phe Ser  Phe Thr Ser Ser Ser  Thr Ala Thr 
    1670                 1675                 1680             


Ser Ala  Ala Leu Leu Cys Asp  Ser Asn Val Val His  Glu Lys Leu 
    1685                 1690                 1695             


Ser Ala  Gln Gly Lys Asp Ser  Glu Ala Gly Glu Arg  Lys Gly Asp 
    1700                 1705                 1710             


Ser Glu  Lys Glu Glu Glu Val  Glu Met Trp Lys Glu  Glu Asp Glu 
    1715                 1720                 1725             


Glu Val  Gln Arg Cys Thr Gly  Ser Ala Glu Thr Asp  Ser Thr Glu 
    1730                 1735                 1740             


Ala Thr  Arg Gly Glu Glu Ala  Trp Arg Arg Gly Lys  Gln Ser Glu 
    1745                 1750                 1755             


Lys Lys  Pro Ser Val Ile Thr  Thr Ala Leu Asn Leu  Leu Glu Thr 
    1760                 1765                 1770             


His Arg  His Leu Ala Leu Thr  Ile Ser Gln Leu Lys  Arg Pro Val 
    1775                 1780                 1785             


Ala Gln  Gln Leu Arg Phe Ile  Leu Pro Ile Ala Ala  Pro Gln Leu 
    1790                 1795                 1800             


Leu Pro  Cys Ile Leu Pro Pro  Ala Ser Phe Gln Gly  Thr Gly Glu 
    1805                 1810                 1815             


Ser Gly  Asp Gly Lys Ala Glu  Ala Glu Ala Lys Gly  Ser Ser Ser 
    1820                 1825                 1830             


Leu Gly  Gln Val Leu Glu Thr  Ala Leu Gly His Gly  Thr Arg Leu 
    1835                 1840                 1845             


Ala Pro  Ser Ala Ser Ala Met  Val Pro Pro Arg Lys  Asp Glu Ala 
    1850                 1855                 1860             


Ala Ser  Ala Val Pro Glu Ala  Lys Thr Leu Thr Gly  Leu Ala Asn 
    1865                 1870                 1875             


Ala Gly  Val Thr Arg Glu Ala  Ala Ser Arg Thr Leu  Glu Ala Glu 
    1880                 1885                 1890             


Gln Val  Ser Arg Lys Arg Ser  Arg Glu Glu Val Val  Asp Ser Glu 
    1895                 1900                 1905             


Thr Ala  Gly Asp Glu Gly Asp  Met Glu Asn Val Pro  Glu Thr Arg 
    1910                 1915                 1920             


Asp Gly  Thr Thr Arg Pro Gly  Ser Arg Gln Tyr Asp  Thr Ser Pro 
    1925                 1930                 1935             


Ser Asn  Asp Gly Thr Lys Pro  Pro Ala Thr Ala Lys  Ser Arg Val 
    1940                 1945                 1950             


Ile Arg  Asp Gln Ala Ala Leu  Glu Arg Leu Leu Leu  Ala Pro Phe 
    1955                 1960                 1965             


Gln Asp  Thr Pro Thr Cys Ser  Cys Thr Asp Arg Pro  Cys Pro Cys 
    1970                 1975                 1980             


Asp Arg  Gln Gln Val Ala Asp  Met Ile Tyr Leu Phe  Tyr Ala Val 
    1985                 1990                 1995             


Pro Ala  Arg Gln Gln Ala Glu  Ser Ser Lys Glu Gly  Ser Thr Gln 
    2000                 2005                 2010             


Arg Leu  Gln Phe Ala Ala Arg  Asp Thr Asn Glu Arg  Lys Asp Ala 
    2015                 2020                 2025             


Arg Thr  Gly Glu Glu Thr Gln  Gly Gly Glu Thr Glu  Ala Lys Glu 
    2030                 2035                 2040             


Val Ile  Arg Asp Pro Glu Glu  Arg Gly Val Cys Glu  Gly Ser Ser 
    2045                 2050                 2055             


Ser Gln  Asn Ala His Thr Gln  Phe Asp Ala Glu Thr  Ala Ser Ser 
    2060                 2065                 2070             


Ser Met  Ser Ser Asp Pro Arg  Ala Asp Lys Glu Ser  Asn Ala Gln 
    2075                 2080                 2085             


Asp Ala  His Met Ala Asp Lys  Thr Ser Phe Val Ser  Asp Leu Pro 
    2090                 2095                 2100             


Gln Pro  Ser Gly Glu Phe Ala  Pro Ser Leu Leu Ser  Glu Thr Ser 
    2105                 2110                 2115             


Leu Asp  Val Ala Met Ala Asp  Ser Arg Gly Thr Pro  Ser Glu Ile 
    2120                 2125                 2130             


His Gly  Phe Phe Thr Arg Ser  Asp Glu Gln Lys Arg  Ala Ser Phe 
    2135                 2140                 2145             


Ser Ser  Ser Ser Leu Leu Ala  Ala Gly His Ala Val  Ala Ser Phe 
    2150                 2155                 2160             


Ser Ser  Ser Leu Ala Gly Val  Val Ser Gly Ala Gly  Glu Arg Arg 
    2165                 2170                 2175             


Glu Cys  Ala Gly Pro Ser Leu  Gly Asp Leu Ser Thr  Ile Gly Leu 
    2180                 2185                 2190             


Leu Ser  Leu Ser Tyr Pro Ala  Met Leu Ala Phe Ile  Leu Pro Leu 
    2195                 2200                 2205             


Gln Ser  Leu Leu His Thr Val  Ser Gly Met Ile Leu  Thr Leu His 
    2210                 2215                 2220             


Lys Lys  Leu Ile His Arg Phe  Ile Cys Ala His Leu  Arg Leu Val 
    2225                 2230                 2235             


Leu Asp  Asp Asp Met Arg Arg  Pro Ala Gly Gly Ala  Leu Lys Ser 
    2240                 2245                 2250             


Arg Gly  Ala His Gly Asp Thr  Glu Ala Ala Glu Ala  Gln Val Glu 
    2255                 2260                 2265             


Arg Arg  Arg Arg Glu His Glu  Arg Glu Glu Thr Thr  Asn Leu Ala 
    2270                 2275                 2280             


Ile Gly  Tyr Arg Glu Gly Asn  Ala Glu Ala Ala Asn  Thr Phe Pro 
    2285                 2290                 2295             


Leu Val  Asp Thr Val Ser Ser  Leu Leu Ser Pro Gly  Ser Leu Arg 
    2300                 2305                 2310             


Gln Glu  Asn Ser Glu Val Glu  Arg Arg Asp Asn Asp  Glu Glu Arg 
    2315                 2320                 2325             


Leu Glu  Leu Ile Thr Gly Ile  Ala Arg Glu Ser Pro  Lys Pro Ser 
    2330                 2335                 2340             


Glu Lys  Asp Ser Val Ser Pro  Phe Leu Ser Thr Ala  Pro Cys Pro 
    2345                 2350                 2355             


Gly Thr  Glu Ala Glu Ser Ser  Asp Cys Ser Ala Ser  Ser Ala Cys 
    2360                 2365                 2370             


Ser Gly  Thr Pro Thr Glu Gly  Thr Glu Gly Gly Glu  Thr Gly Asp 
    2375                 2380                 2385             


Ile Ala  Ser Phe Leu Ser Pro  Ser Gly Glu Val Lys  Gln Thr Ile 
    2390                 2395                 2400             


Met Leu  Ala 
    2405     


<210>  3
<211>  1217
<212>  DNA
<213>  Homo sapiens

<400>  3
tatccagttg cccggctctg tctaccttct tctcgatgta gcggcggcgt tctgtgttcc       60

ttagagcgag tccacgcacc agcctcgtgg agtcgaacag ttttcgccag agcggggaca      120

gccggtggaa gacagaacag gagggattca ccgtcacctc gtttgcttcc ttctggtgat      180

ggagggaata agccgacaga ctcacttctt aacagttcat ggcagagggg caacgacgtc      240

accatccagc tttccattca cttaaccgca caagcgttct gctcgttagt caagcctcac      300

tcgccagtcg aaagccatta aaagttcgcg tttctggctc tcgtttgtgc cggaagtctg      360

ccaaagcaaa caaaggatct gaaaccgagt agcagtgaac gcgtgacagt gcagaggggt      420

gcccgcgtcg gcgtcctctc tgtccacgaa cagccacaat tctcatcacg agaagtcctc      480

ctcccctgga tcttcctcca gttccccatg actgcctccg gttctcgcac ggacggcgat      540

ccgccttcac gctccccggc ctttgccagt tttgtgcaag aaggtcgccc gtcttattct      600

tgtcacgttc cctgtatcta ctcggttcac tgcgctctac agaagctctt cttcgccttc      660

tactgatcag tgcactctac gagatgcact atcatcagtc ctgaactcca tgtttgggtg      720

gaaacctggg cgtgctgtgt cgcagcgagt cgcgagattg ccggcctgtc gacgagttcc      780

cgtttttcct gcactggcta cagcgtagcg gcttcgcctg ctcactggcg acggtactgg      840

ccgcacggtt tcacgatcct gaggtcggcg agatgcccct gtctggcgag gccttttgtc      900

tacgcagcga cctctgtcta ctagagaaag gcagaaggcc ggagcgtttt ctcagatgtg      960

ctactctttg tcttctgcga tcttccgtgc gttcagctgt gcttttgcca aaggagacct     1020

gtgtgcagag gacttcgctg ctaaaaagca gaagagtgcg cggcgtgtgt agctcagtgg     1080

catttcggga ctcggtcttg cgtcgttcgc gactggacgt cgtcgtctgt gagagcgtca     1140

aactagggag aaggggcggg ccagagcgtt cggaaaatta tctgcaaagc ccaggtcccg     1200

tatgatattc aaaaaag                                                    1217


<210>  4
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  5
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  5
agtgttctcg aaaccatgct aacac                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  6
cctcttacct cagttacaat ttata                                             25


<210>  7
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Ser Arg Arg Cys Lys Arg Ser Ser Ala Glu Asp Ser Gly Ala 
1               5                   10                  15      


Asn Glu Val Gly Ala Asn Ala Asp Gln Ser Lys Arg Leu Arg His Ser 
            20                  25                  30          


Leu Asp Ser Ile Ile Glu Lys Gly Gly Asp Pro Val Asn His Asp Ser 
        35                  40                  45              


Ala Met Leu Leu Asp Cys Ala Pro Thr Gln Thr Gly Arg Ala Phe Ala 
    50                  55                  60                  


Phe Leu Ser Met Pro Ala Pro Ile Glu Pro Ser Gly Asn Glu Glu Ser 
65                  70                  75                  80  


Ala Pro Ala Val His Arg Asp Ser Gly Val Gly Gly Ile Asp Tyr Pro 
                85                  90                  95      


Arg Pro Val Ala Ser Ile Ser Val Glu Ser Ser Ser Gln Val Val Ala 
            100                 105                 110         


Pro Arg Asp Glu Asn Pro Ser Ala Ser Tyr Gln Arg Arg Gly Asp Ser 
        115                 120                 125             


Pro Pro Ser Leu Arg Asn Gly Gly Asp Arg Gln Glu Arg Lys Arg Thr 
    130                 135                 140                 


Ala Val Ala Pro Glu Ala Asn Glu Pro Gln Asp Asn Glu Thr Lys Asn 
145                 150                 155                 160 


Glu Glu Trp Leu Gln Leu Ala Arg Leu Lys Pro Lys Val Glu Gly Val 
                165                 170                 175     


Cys Phe Asp Arg Phe Phe Arg Arg Trp Val Ala Lys Arg Ala Gly Leu 
            180                 185                 190         


Lys Lys Val Tyr Phe Pro Val Tyr Lys Tyr Gly Phe Asp Arg Ala Tyr 
        195                 200                 205             


Glu Leu Ala Val Ala Thr Arg Arg Gly Leu Glu Asn Asp Ala Ala Ala 
    210                 215                 220                 


Gly Ile Arg Ala Val Gly Ala Leu Arg Pro Arg Ile Ser Glu Ala Ala 
225                 230                 235                 240 


Gly Cys Thr Ser Ser Pro Gly Met Leu Ser Glu Asp Ala Cys Pro Glu 
                245                 250                 255     


Lys Pro Pro Val Pro Val Gln Pro Pro Arg Thr Leu Ser Thr Arg Ala 
            260                 265                 270         


Thr Ala Ala Gln Ala Glu Val Lys Ser Gly Asp Ser Ala Glu Ser Thr 
        275                 280                 285             


Lys Asn Asp Ser Glu Gly Ala His Val Leu Glu Gly Ala Glu Leu Gln 
    290                 295                 300                 


Thr Pro Glu Arg Ser Thr Ser Asn Thr Ile Cys Trp Ala Thr Ala Ala 
305                 310                 315                 320 


Glu Gly Ser Ile Ser Lys Thr Asp Gly Phe Gln Asn Arg Ser Ser Pro 
                325                 330                 335     


Ser Gly Phe Gly His Gly Ser Arg Asn Lys Pro Glu Leu Ser Gln Gln 
            340                 345                 350         


Lys Val Glu Thr Thr Ser Arg Gly Ile Arg Ser Ala Ser Ala Ser Cys 
        355                 360                 365             


Asn Arg Glu Lys Asp Gln Gly Gly Ser Ala Cys Ser Val Leu Ser Ile 
    370                 375                 380                 


Ala Ser Phe Ser Leu Ser Gln Ile Asp Glu Glu Leu Glu Gly Ile Asn 
385                 390                 395                 400 


Asp Glu Ala Tyr Glu Ala Glu Arg Leu Gln Ala Asp Glu Asp Arg Ser 
                405                 410                 415     


His Ala Pro Ala Ala Ser His Gly Glu Gly Gly Thr Ser Ala Gly Glu 
            420                 425                 430         


Ser Thr Ala Ala Ser Thr Thr Gly Ser Glu Asp Ser Gly Pro Leu Arg 
        435                 440                 445             


Ala Ala Thr Ser Pro Leu Met Phe Pro Gln Gly Ser Glu Gly Ser Ala 
    450                 455                 460                 


Ser Ser Ala Ser Thr Glu Ile Met Val Leu Asp Asp Glu Ser Met Gln 
465                 470                 475                 480 


Gln Ala Leu Val Thr Ala Ser Ala Glu Thr Leu Asn Lys Leu Arg Ser 
                485                 490                 495     


Thr Leu Pro Ala Gly Val His Phe Asp Phe Ala Ser Lys Arg Trp Phe 
            500                 505                 510         


Ala Val Tyr Ser Ser His Glu Ser Pro Glu Ala Thr Gln Arg Asp Pro 
        515                 520                 525             


Val Arg Pro Lys Glu Arg Val Arg Ile Phe Asp Pro Thr Gln Tyr Glu 
    530                 535                 540                 


Gly Ser Met Leu Lys Ala Phe His Ala Cys Arg Ser Phe Cys Gly Ser 
545                 550                 555                 560 


Val Glu Ala Gly Ala Ser Asp Trp Asp Ser Val Pro Gln Leu Val Pro 
                565                 570                 575     


Glu Gln Arg Lys Gln Gly Glu Cys Gln Asp Thr Ser Gly Ser Ser Asp 
            580                 585                 590         


Gln Gly Ala Asn Arg Leu Ser Pro Thr Glu Thr Glu Asn Pro Pro Thr 
        595                 600                 605             


Ala Asp His Pro Arg Ser Leu Ser Ala Thr Thr Arg Pro Glu Gly Ser 
    610                 615                 620                 


Leu Glu Gln Thr Gln His Pro Gln Arg Asn Arg Gly Ile Leu Gly Ile 
625                 630                 635                 640 


Gln Pro Gly Glu Thr Glu Gly Leu Gln Val Pro Ser Asn Gly His Gly 
                645                 650                 655     


Val Asn Ala Gly Asp Ile Glu Thr Asn Leu Leu Asp Ala Glu Phe Gly 
            660                 665                 670         


Ser Glu Thr Arg Ala Arg Thr Thr Ala Leu Pro His Leu Arg Arg Ser 
        675                 680                 685             


Gln Arg Arg Ala Asp Pro Ala Arg Ser Val His Ser Asn Thr Phe Ala 
    690                 695                 700                 


Gly Gln Glu Leu His Gln Ser Pro Lys Pro Gly Asn Gln Thr Ser Arg 
705                 710                 715                 720 


Gly Glu Ser Gly Arg Ser Ser Leu Arg Arg Lys Asn Gln Val Ser Thr 
                725                 730                 735     


Asn Glu Lys Gly Leu Pro Gly Glu Gly Gly Cys Arg Thr Asp Glu Lys 
            740                 745                 750         


Ser Lys Gln Val Ser Tyr Val Ser Phe Ser Glu Pro Ile Thr Val Arg 
        755                 760                 765             


Tyr Gln Gln Val Pro Thr Glu Ser Ala Ser Thr Arg Gly Cys Ser Gln 
    770                 775                 780                 


Arg Arg Pro Gln Asn Ala Glu Glu Leu Glu Asp Arg Arg Ser Pro Leu 
785                 790                 795                 800 


Thr Arg Gln Glu Glu Arg Thr Glu Ser Asp Pro Arg Thr Thr Ala Gly 
                805                 810                 815     


Leu Cys Gln Glu Asn Pro His Pro Ser Tyr Arg Phe Leu Arg Gln Gln 
            820                 825                 830         


Ser Arg Glu Leu Ala Val Arg Cys Leu Leu Val Ile Phe Gly Asn Leu 
        835                 840                 845             


Ala Asp Val Cys Thr Pro Ala Leu Phe Arg Leu Phe Pro Gln Asp Arg 
    850                 855                 860                 


Cys Arg Arg Val Arg Ala Val Leu Gln His Arg Asp Leu Leu Gln Ser 
865                 870                 875                 880 


Gly Lys His Thr Arg Val Leu Leu Ser Ala Tyr Phe Gln Leu Phe Trp 
                885                 890                 895     


Pro Leu Leu Glu Thr Arg Thr Leu Pro Gln His Tyr Ser Ala Asp Tyr 
            900                 905                 910         


Ile Arg Arg Leu Leu Asn Gly Met His Asn Val Ala Ala Met His Lys 
        915                 920                 925             


Ser Leu Phe Pro Glu Tyr Pro Leu Arg Gly Glu Leu Asp Asn Arg Glu 
    930                 935                 940                 


Gly Pro Tyr Ala Phe Leu Asp Asp Thr Ala Ala Glu Gly Ile Asn Phe 
945                 950                 955                 960 


Phe Glu Thr Asp Phe Asp Glu Pro 
                965             


<210>  8
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Tyr Gln Arg Arg Arg Ala Ala Ala Cys Thr Ile Glu Val Ser 
1               5                   10                  15      


Arg Asp Leu Phe Ser Pro Glu Arg Asn Leu His Asp Asn Phe Ser Ser 
            20                  25                  30          


Leu Ala Ile Thr Met Ala Phe Arg Thr Val Ser Lys Val Leu Pro Thr 
        35                  40                  45              


Leu Ser His Cys Phe Pro Gly Pro Leu Ser Val Ala Ala Ser Ser Ser 
    50                  55                  60                  


Leu Pro Gly His Ser Lys Gly Glu Glu Ser Val Pro Cys Arg Val His 
65                  70                  75                  80  


Arg Ser Phe Arg Leu Ser Pro Val Ala Asp His Glu Ala Glu Ala Leu 
                85                  90                  95      


Ser Gly Ser Gly Asn Asp Thr Ser Gly Cys Ser Gln Arg Asp Arg Phe 
            100                 105                 110         


Cys Ala Gly Asn Gly Ser Asp Cys Lys Ala Arg Arg Thr Ser Asp Gly 
        115                 120                 125             


Asn Gly Ser Pro Pro Thr Asn Ala Arg Met Ser Glu Lys Leu Ser Leu 
    130                 135                 140                 


Phe Lys Asn His Ala Tyr Ser Cys Leu Glu Gln Arg Ala Cys Pro Ala 
145                 150                 155                 160 


Ser Asn Arg Asn Leu Gly Asp Thr Ala Ala Cys Pro Leu Ser Ala Phe 
                165                 170                 175     


Cys Arg Ser Leu Val Arg Arg Thr Pro Ser Arg Leu Trp Leu Pro Pro 
            180                 185                 190         


Gln Cys Ser Leu Leu Ser Gly Cys Ser Ala Arg Ser Cys Pro Pro Lys 
        195                 200                 205             


Ile Ser Val Arg Ala Thr Asn Gly Ala Ser Glu Gln Ala Ser Trp Gln 
    210                 215                 220                 


Asp Phe His Pro Ala Leu Gly Arg Ala Val Val Pro Leu Ser Leu Ser 
225                 230                 235                 240 


Gly Arg Gly Thr Ala Gly Thr His Leu Val Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Arg Val Val Gln Lys Arg Arg His Gln Met Arg Ile Leu His Pro Ala 
            260                 265                 270         


Gln Thr Ala Tyr Val Pro Val Glu Gln Arg Pro Pro Pro Ile Pro His 
        275                 280                 285             


Ser Leu Thr Ala Ser Ser Thr Val Lys Arg Leu Leu Asn Asn Asn Thr 
    290                 295                 300                 


Val Ala Ala Lys Glu Ala Ala Lys Arg Ile Asn Trp Gly Ala Tyr Ile 
305                 310                 315                 320 


Ser His Gln Arg Gly Val Arg Trp His Pro Gln Gly Ala Trp Arg Val 
                325                 330                 335     


Gln Phe Ser Arg Arg Asn His Glu Arg Asn Phe Phe Val Arg Cys Glu 
            340                 345                 350         


Cys Tyr Phe Arg Val Gly Thr Tyr Gly Phe Gln Met Ala Lys Asp Leu 
        355                 360                 365             


Ala Ile Arg Tyr Arg Gln Arg Leu Glu Lys Glu Trp Glu Glu Leu Gln 
    370                 375                 380                 


Glu Gln Trp Thr Lys Leu Asp Ile Leu Glu Ala Glu Gln Arg Ala Lys 
385                 390                 395                 400 


Tyr Lys Glu Lys Arg Glu Glu His Leu Leu Leu Gly Ala Gly Glu Glu 
                405                 410                 415     


Pro Glu Leu His Ser Arg Arg Ser Lys 
            420                 425 


<210>  9
<211>  2674
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Gly Ser Gly Glu Ser Ser Gly His Leu Phe Lys Pro Gly His 
1               5                   10                  15      


Gly Glu Ala Arg Val Ser Val His Arg Gly Ser Leu Thr Asp Ser Gly 
            20                  25                  30          


Ser Leu Pro Ala Ala Ser Arg Cys His Ser Gln Asp Asn Lys Leu Ser 
        35                  40                  45              


Leu Pro Cys Ala Gly Ser Met Leu Pro Ala Ser Ser Gly Arg Phe Ser 
    50                  55                  60                  


Cys Asp Ser Ala Leu Phe Gly Gly Pro Val Asp Ser Ala Cys Ser Ser 
65                  70                  75                  80  


Asp Trp Thr Pro Val Val Ser Pro Ser Arg Asp Leu Ser Ala Asp Gly 
                85                  90                  95      


Thr Asp Ser Ser Ser Val Ser Gly Ser Arg Gly Ser Ser Leu Pro Phe 
            100                 105                 110         


Gly Ser Pro Thr Ser Ala Leu Leu Arg Pro Ser Ser Glu Ala Ser Ala 
        115                 120                 125             


Asn Phe Pro Arg Leu His Lys Ser Val His Ala Leu Asp Asp Lys Met 
    130                 135                 140                 


Arg Gly Leu Asp Ala Gln Leu Tyr Val Arg Pro His Gln Thr Leu Pro 
145                 150                 155                 160 


Leu Gln Pro Arg Leu Arg Glu Thr Asp Leu Cys Arg Asn Gly Glu Asp 
                165                 170                 175     


Gly Arg Pro Gly Lys Phe Asp Ser Pro His Leu Gly Ser Ser Ala Gly 
            180                 185                 190         


Pro Tyr Gly His Ser Phe Leu Ala Asn Pro Gln Leu Thr Pro Phe Val 
        195                 200                 205             


Pro Gln His Leu Ser Ser Ser Pro Pro Gln Pro Val Leu Ser Pro Pro 
    210                 215                 220                 


Gly Glu Glu Gly Arg Asn Ser Ala Ala Phe Gly Lys Thr Val Ser Arg 
225                 230                 235                 240 


Leu Asn Thr Gly Gly Gly Glu Arg Gln Asp Ser Ser Glu Asp Gln Val 
                245                 250                 255     


Gly Gly Thr Gly Arg Gln Ser Asp Gln Ala Thr Lys Ala Asn Ser Gly 
            260                 265                 270         


Ser Thr Pro Ala Gly Cys Ala Gln Thr Ala Gly Leu Leu Thr Asp Val 
        275                 280                 285             


Gln Ser Ser Gly Thr Asn Val Glu His Gly Arg Glu His Phe Ser Thr 
    290                 295                 300                 


Pro Gln Lys Pro Ala Asp Gly Ser Ala Arg Thr Cys Gly Phe Arg Glu 
305                 310                 315                 320 


Thr Arg Val Ser Pro Ser Asn Ser Ser Leu Pro Arg Thr Ala Cys Arg 
                325                 330                 335     


Ser Arg Leu Asp Ala Phe Leu Pro Gln Lys Ser Val Ser Pro Asp His 
            340                 345                 350         


Glu His Val Arg Gly Thr Gly Gly Ala Arg Ala Phe Val Gly Gly Asp 
        355                 360                 365             


Ser Pro Phe Pro Glu Lys Pro Asp Thr Leu Pro Ala Thr Val Thr Ala 
    370                 375                 380                 


Glu Leu Ala Thr Glu Ala Pro Pro Ala Ser Arg Asp Pro Pro Val Glu 
385                 390                 395                 400 


Glu Phe Pro Gly Ala His Glu Leu Glu Ser Leu Pro Pro Pro His Val 
                405                 410                 415     


Asn Ser Gly Arg Pro Pro Ile Gly Glu Lys Asp Gly Ala Ala Ala Ser 
            420                 425                 430         


Pro Gly Val Ser Arg Leu Pro Ser Gln Glu Arg Val His Thr Leu Leu 
        435                 440                 445             


Tyr Pro Asn Glu Lys Asp Ala Ser Ser Leu Ser Arg Cys Cys Pro Ser 
    450                 455                 460                 


Ser Met Gln Pro Pro Pro Ala Gly Pro Arg Gln Glu Glu Ala Arg Ser 
465                 470                 475                 480 


Phe Ser Val Ser Ala Ala Ser Ala Pro Gly Ala Pro Pro Gly Ile Val 
                485                 490                 495     


Tyr Gln Ala Ser Ala Cys Ala Ser Pro Ala Thr Val Ala Ser Phe Ala 
            500                 505                 510         


Thr Pro Leu Thr Thr Pro Val Gly Ala Ser Ala Gln Ser Glu Pro Ala 
        515                 520                 525             


Ala Leu His Ala His Ser Arg Ser Arg Thr Gly Ala His Pro Glu Ala 
    530                 535                 540                 


Leu Pro Pro Gly Val Pro Gly Val Thr Ser Gln Leu Gly Arg Gly Ala 
545                 550                 555                 560 


Arg Gly Asp Arg Glu Thr Leu Ala Gly Gly Ala Arg Pro Gly Gln Asp 
                565                 570                 575     


Gly Val Cys Glu Arg Arg Gly Asp Val Ala Arg Gly Arg Leu Gly Gly 
            580                 585                 590         


Val Ser Val Ala Gly Asp Glu Ala Ala Glu Gly Thr Ser His Lys Ala 
        595                 600                 605             


Ala Leu Glu Gly Ala Tyr Val Gln Asp Gly Cys Ser Pro Gln Pro Leu 
    610                 615                 620                 


Asn Pro His Ala Pro Ser Gly Ile Ser Ala Pro Thr Asn Gly Ser Ser 
625                 630                 635                 640 


Glu Leu Ala Ser Ser Ala Ile Pro Ala Ser Thr Cys His Asp Ala Phe 
                645                 650                 655     


Val Arg Ser Pro Val Ser Gly Ser Asp Cys Met Ser Val Ala Asn Pro 
            660                 665                 670         


Gly Gly Pro Pro Gly Ala Leu Gly Gly Leu Phe Pro Ser Pro Arg Gly 
        675                 680                 685             


Pro Ser Gly Pro Arg Pro Thr Pro His Pro Ala Gln Met Ala Phe Ala 
    690                 695                 700                 


Phe Val Gly Gln Gln Pro Val Phe Pro Gly Phe Asp Ala Ser Gln Pro 
705                 710                 715                 720 


Ala Gly Ser Thr Phe Gln Tyr Pro Pro Ile Arg Gly Ala Val Ser Gly 
                725                 730                 735     


Val Ser Pro Pro Pro Pro Met His Pro Ser Ser Phe Ala Gln Pro Val 
            740                 745                 750         


Trp Ser Pro Thr Ser Val Pro Ser Ser Ser Val Ser Ser Ser Val Ser 
        755                 760                 765             


Ser Ser Gly Val Ser Ser Ser Ala Pro Pro Pro Leu Ala Val Gly Phe 
    770                 775                 780                 


Gln Asn Pro Cys Pro Trp Arg Pro Thr Ala Pro Arg Asp Arg Ser Glu 
785                 790                 795                 800 


Gly Gly Ala Gly Ser Pro Gly Val Ser Cys Gly Ser Ala Pro Pro Ala 
                805                 810                 815     


Pro Thr His Pro Thr Gly Lys Gly Gly Ala Ala Gly Arg Ala Gly Lys 
            820                 825                 830         


Gln Leu Gly Gln Ala Thr Arg Phe Leu Ser Ser Val Ser Gly Val Val 
        835                 840                 845             


Tyr Asp Lys Gly Gly Glu Lys Trp Ile Ala Arg Trp Ser Glu Asn Gly 
    850                 855                 860                 


Lys Pro Phe Lys Lys Thr Phe Ala Val Gly Lys His Gly Phe Asp Ala 
865                 870                 875                 880 


Ala Arg Lys Met Ala Glu Asp Cys Arg Leu Gln Ala Leu Tyr Ala Lys 
                885                 890                 895     


Arg Trp Asn Ser Ala Ser Gly Leu Pro Ala Ser Phe Ser Lys Ser Asn 
            900                 905                 910         


Ser Leu Gly Arg Ser Thr Pro Gly Asp Arg Gly Lys Thr Glu Ser Thr 
        915                 920                 925             


Asn Ser Ala Lys Cys Lys Arg Asp Thr Ser Gly Glu Ser Gly Cys Thr 
    930                 935                 940                 


Asp Thr Gly Leu Arg Ser Leu His Met Gly Gly Ala Gly Asp Leu Ser 
945                 950                 955                 960 


Ser Leu Gly His Pro Gly Thr Pro Pro Arg Asp Gln Glu Gly Ala Pro 
                965                 970                 975     


Ala Ser Phe Leu Leu Glu Gly Thr Gly Val Val Arg Ser Ser Gln Val 
            980                 985                 990         


Gln Thr Pro Phe Arg Leu Tyr Asp  Ser Val Pro Ser Pro  Leu Arg Ser 
        995                 1000                 1005             


Gly Asp  Ala Leu Gly Ala Gln  Arg Gly Leu Val Pro  Gln Leu Leu 
    1010                 1015                 1020             


Asn Asn  Ala Leu Val Gly Val  Pro Phe Ala Pro Pro  Pro Gly Ala 
    1025                 1030                 1035             


Ser His  Ser Gly Cys Ser Ala  Ala Leu Pro Pro Gly  Pro Gly Ala 
    1040                 1045                 1050             


Pro Val  Gln Val Ser Ser Pro  His Thr Gly Phe Val  Ala Pro Ala 
    1055                 1060                 1065             


Asp Val  Asp Ala Pro Pro Arg  Asp Gly Leu Glu Gly  Leu Gly Gly 
    1070                 1075                 1080             


Ala Ala  Glu Val Ser Pro Gln  Ile Ala Val Gln Asp  Gly Gly Lys 
    1085                 1090                 1095             


Lys Gly  Glu Gly Leu Leu Gly  Ser Ala Ser Leu Ser  Val Arg Arg 
    1100                 1105                 1110             


Arg Arg  Lys Arg Glu Pro Asp  Glu Lys Phe Ser Pro  Gly Glu Ser 
    1115                 1120                 1125             


Asn Ala  Ala Val Lys Lys Thr  Pro Arg Pro Gly Ser  Phe His Pro 
    1130                 1135                 1140             


His Ser  Cys Pro Gly Ser Glu  Gly Phe Arg Ser His  Asp Gly Pro 
    1145                 1150                 1155             


Gly Asp  Ser Thr Glu Ala Arg  Cys Ala Gly Leu Pro  Ala Phe Gln 
    1160                 1165                 1170             


His Ala  Thr Ala Pro Ser Ser  Val Cys Trp Pro Ser  Thr Ala Ser 
    1175                 1180                 1185             


Leu Pro  Ser Leu Asp Lys Ala  Gly Gln Arg Ala Glu  His Ala Gly 
    1190                 1195                 1200             


Pro Ser  Ala Phe Ser Ser Phe  Ser Ser Val Gln Gln  Ser Pro Gly 
    1205                 1210                 1215             


Ser Val  Glu Thr Trp Arg Pro  Glu Gly Asp Gly Gly  Pro Ala Ser 
    1220                 1225                 1230             


Pro Ala  Arg Asp Ala Gly Arg  Arg Gly Ala Glu Ser  Glu Glu Arg 
    1235                 1240                 1245             


Glu Thr  Gly Glu Leu Ala Gly  Pro Phe Ala Gly Val  Ser Ala Ser 
    1250                 1255                 1260             


Ala Gly  Ser Ala Ser Arg Lys  Gly Gln Gln Lys Gln  Leu Thr Arg 
    1265                 1270                 1275             


Gln Ile  Gln Arg Gln Gln Gln  Leu Tyr Arg Gln Gln  Glu Ala Leu 
    1280                 1285                 1290             


Leu Gln  Asn Gln Glu Glu Leu  Phe Ser Arg Leu Leu  Arg Arg Arg 
    1295                 1300                 1305             


Ser Arg  Gln Glu Arg Ser Asp  Val Arg Arg Arg Met  Gln Arg Asp 
    1310                 1315                 1320             


Val Ser  Ser Leu Arg Arg Leu  Pro Ala Met Leu Leu  Ser Pro Leu 
    1325                 1330                 1335             


Arg Asp  Thr Leu Val Ala Ser  Ala Ala Arg Leu Pro  Leu Ala Thr 
    1340                 1345                 1350             


Arg Gly  Thr Lys Arg Glu Ser  Gln Lys Glu Arg Arg  Asp Cys Gly 
    1355                 1360                 1365             


Ala Gly  Ile Gly Gly Glu Thr  Ala Ser Glu Lys Lys  Glu Met Ala 
    1370                 1375                 1380             


Glu Pro  Val Arg Val His Arg  Arg Asp Arg Gly Gly  Ala Arg Asp 
    1385                 1390                 1395             


Glu Glu  Lys Pro Ser Thr Glu  Gly Val Arg Gln Ala  Asp Pro Lys 
    1400                 1405                 1410             


Gly Arg  Lys Ala Glu Gly Phe  Pro Thr Trp Val Ile  Pro Pro Asn 
    1415                 1420                 1425             


Glu Glu  Leu Lys Ala Ala Gln  Val Leu Arg Ala Leu  Arg Val Gln 
    1430                 1435                 1440             


Arg Arg  Ala Ala Ala Arg Glu  Gly Lys Leu Leu Glu  Ser Leu Leu 
    1445                 1450                 1455             


Val His  Arg Gly Glu Gly Glu  Gly Thr Phe Ser Glu  Glu Thr Glu 
    1460                 1465                 1470             


Gly Asn  Thr Gly Ile Glu Asp  Ala Gly Thr Glu Ser  Asp Ala Thr 
    1475                 1480                 1485             


Val Thr  Gln Glu Thr Ala Glu  Lys Val Val Glu Asn  Val Gln Lys 
    1490                 1495                 1500             


Met Glu  Glu Leu Glu Ser Lys  Val Glu Lys Glu Asn  Glu Arg Arg 
    1505                 1510                 1515             


Arg Glu  Ala Glu Asp Glu Thr  Pro Lys Gln Ser Ser  Glu Glu Ala 
    1520                 1525                 1530             


Pro Gly  Val Gln Gln Ser Pro  His Lys Leu Ser Thr  Asn Asn Glu 
    1535                 1540                 1545             


Asn Asp  Ala Ser Pro Gln Lys  Leu Thr Lys Ser Val  Arg Phe Ala 
    1550                 1555                 1560             


Glu Ser  Val Ala Gly Ser Ser  Ser Ala Val Gln Thr  Ala Gly Ala 
    1565                 1570                 1575             


Ala Asp  Glu Glu Pro Leu Ala  Thr Glu Thr Leu Glu  Gly Arg Arg 
    1580                 1585                 1590             


Val Gly  Gly Ile Pro Val Pro  Ala Thr Ser Ser Pro  Ala Pro Val 
    1595                 1600                 1605             


Phe Pro  Cys Thr Ala Ala Gln  Leu Gly Asp Leu Cys  Met Asp Thr 
    1610                 1615                 1620             


Leu Tyr  Ala Leu Gly Thr Val  Arg Pro Gln Trp Arg  Arg Gln Asp 
    1625                 1630                 1635             


His Arg  Arg Ala Phe Gly Trp  His Leu Ser Gln Ile  Lys Pro Asp 
    1640                 1645                 1650             


Leu Ile  Leu Pro Ser Leu His  Ala Ser Arg Val Leu  Arg Arg Leu 
    1655                 1660                 1665             


Ser Pro  Arg Pro Ser Asn Ala  Val Glu Phe Pro Arg  Glu Glu Leu 
    1670                 1675                 1680             


Ala Ala  Ala Ser Ser Ala Ala  Gly Leu Val Tyr Gly  Glu Gly Leu 
    1685                 1690                 1695             


Ser Ser  His His Thr Leu Arg  Ser Tyr Val Asp Ala  Phe Arg Pro 
    1700                 1705                 1710             


Leu Phe  Ser Ser Pro Ser Ser  Pro Pro Leu Glu Phe  Leu His Leu 
    1715                 1720                 1725             


Ser Ser  Gly Asp Leu Leu Met  Ser Leu Trp Gln Leu  Glu Glu Gly 
    1730                 1735                 1740             


Gly Arg  Ala Ala Val Ile Asp  Asn Val Leu Leu Ala  Leu Asp Ala 
    1745                 1750                 1755             


Leu Tyr  Glu Arg His Thr Gly  Arg Arg Leu Arg Gly  Thr Ala Pro 
    1760                 1765                 1770             


Pro Pro  Phe Ala Val Ser Ser  Pro Ser Ser Ala Pro  Ser Ser Leu 
    1775                 1780                 1785             


Phe Ala  Leu Ala His Leu Gln  Gly Gly Ala Thr Ser  Thr Thr Pro 
    1790                 1795                 1800             


Leu Pro  Ala Thr Ala Leu Pro  Ser Pro Pro Phe Pro  Arg Val Ser 
    1805                 1810                 1815             


Ser Ala  Pro Asp Ser Pro Val  Phe Ala Pro Asp Ala  Ser His Gly 
    1820                 1825                 1830             


Pro Ser  Gln Arg Arg Gln Val  Ser Pro His Val Thr  Phe Glu Thr 
    1835                 1840                 1845             


Pro Pro  Thr His Pro Arg Asp  Arg Asp Ser Glu Thr  Ser Val Glu 
    1850                 1855                 1860             


Arg Asn  Ala Ser Pro Glu Ala  Ser Pro Gln Ala Ala  Thr Leu Ala 
    1865                 1870                 1875             


Ala Pro  Ala Pro Cys Asp Gly  Asp Arg Glu Glu Asn  Phe Val Leu 
    1880                 1885                 1890             


Ala Tyr  Asn Pro Glu Ala Lys  Ala Leu Arg Gln Val  Asn Phe Leu 
    1895                 1900                 1905             


Ala Val  Gly Val Arg Val Phe  Leu His Leu Glu Val  Val Glu Glu 
    1910                 1915                 1920             


Met Leu  His Leu Gln Ala Lys  Met Gln Arg Thr Pro  Gly Arg Asp 
    1925                 1930                 1935             


Asp Arg  Ala Thr Ala Ser Ser  Gly Pro Ser Val Asp  Asp Gly Ser 
    1940                 1945                 1950             


Gly Leu  Met Thr Ser Leu Pro  Ser Thr Cys Ser Gly  Val Ser Gly 
    1955                 1960                 1965             


Lys Lys  Asp Pro Met His Trp  Ser Ala Leu Phe Val  Thr Val Pro 
    1970                 1975                 1980             


Ala Pro  Ser Val Ser Thr Ala  Ala Ser Lys Pro Leu  Phe Val Val 
    1985                 1990                 1995             


Ala Glu  Met Val Asp Arg Arg  Leu Gln Val Pro Cys  Gly Glu Gln 
    2000                 2005                 2010             


Leu Leu  Phe Arg Pro Leu Pro  Leu Ser Pro Ala Ala  Pro Ser Ala 
    2015                 2020                 2025             


Leu Leu  Ala Phe Ala Pro Ala  Arg Val Cys Gln Leu  Leu Arg Ala 
    2030                 2035                 2040             


Gly Ala  Met Cys Leu Thr Arg  Phe Thr Glu Lys Glu  Gly Gly Lys 
    2045                 2050                 2055             


Arg Pro  Arg Gly Ser Ala Gln  Arg Cys Ser Ala Ala  Ser Ser Phe 
    2060                 2065                 2070             


Phe Tyr  Ser Pro Pro Pro Leu  Asp Leu Ser His Leu  Ala Ser Phe 
    2075                 2080                 2085             


Ala Pro  Ala Ala Ser Thr Leu  Thr Pro Pro Ser Ser  Pro Ala Ser 
    2090                 2095                 2100             


Ser Pro  Ser Ala Ser Ala Ser  Gln Thr Gly Pro Gly  Arg Ala Lys 
    2105                 2110                 2115             


Ser Arg  Gly Thr Ser Pro Val  Gly Pro Glu Ser Pro  Glu Ala Ala 
    2120                 2125                 2130             


Ser Thr  Thr Ser Asp Gly Leu  Ala Val Pro Gly Ser  Ala Ser Ala 
    2135                 2140                 2145             


Val Ser  Thr Pro Gly Val Pro  Ala Gly Ala Ser Gly  Ala Ser Leu 
    2150                 2155                 2160             


Gly Ala  Pro Ala Pro Ser Pro  Met Ala Ser Pro Gly  Gly Ser Pro 
    2165                 2170                 2175             


Gly Arg  Pro Pro Lys Pro Val  Cys Cys Pro Ala Ala  Pro Gly Ile 
    2180                 2185                 2190             


Glu Thr  Ala Trp Arg Cys Lys  Cys Ser His Arg Arg  His Glu Leu 
    2195                 2200                 2205             


Gln Leu  Glu Ile Lys Gln Lys  Leu Arg Gln Asp Lys  Lys Arg Cys 
    2210                 2215                 2220             


Leu Ala  Leu Ile Arg Glu Tyr  Pro Asp Leu Ser Leu  Leu Val Gly 
    2225                 2230                 2235             


Ala Pro  Pro Ala Thr Pro Arg  Glu Lys Glu Thr Gly  Ala Lys Arg 
    2240                 2245                 2250             


Gln Ala  Pro Glu Gly Arg Arg  Thr Ala Thr Pro Ser  Gly Ser Gly 
    2255                 2260                 2265             


Thr Leu  Thr Ala Lys Gly Gly  Asp Leu Gln Gly Ser  Thr Pro Ser 
    2270                 2275                 2280             


Gly Ala  Gly Leu Leu Ser Leu  Ala Arg Thr Ser Gln  Leu Glu Met 
    2285                 2290                 2295             


Leu Ala  Tyr Leu Val Glu Val  Asp Pro Trp Lys Tyr  Ala Lys Asn 
    2300                 2305                 2310             


Arg Gln  Asp Ala Pro Lys Pro  Glu Glu Ile Pro Gly  Leu Leu Ala 
    2315                 2320                 2325             


Lys Tyr  Lys Ala Ala Val Arg  Thr Ala Glu Tyr Gly  Arg Met Leu 
    2330                 2335                 2340             


Gln Lys  Trp Arg Ala Gly Gln  Ser Arg Glu Asp Glu  Gly Arg Gly 
    2345                 2350                 2355             


Gly Ala  Asp Gly Arg Lys Glu  Gly Asp Gly Leu Leu  Ser Pro Thr 
    2360                 2365                 2370             


Ala Ser  Pro Pro Ser Arg Arg  Lys Gln Gly Lys Asp  Ser Ser Pro 
    2375                 2380                 2385             


Asn Ser  Ala Ser Ser Gln Ala  Ser Gly Pro Ala Pro  Ser Pro Ser 
    2390                 2395                 2400             


Leu Ser  Pro Gly Ala Gly Ala  Ala Ala Val Leu Glu  Ala Glu Lys 
    2405                 2410                 2415             


Pro Glu  Pro Gln Ser Pro Gln  Glu Ser Pro Cys Pro  Leu Glu Pro 
    2420                 2425                 2430             


Ala Ala  Gly Gln Glu Pro Arg  Ala Thr Ser Ser Ala  Leu Pro Ala 
    2435                 2440                 2445             


Gly Ser  Pro Pro Trp Ala Leu  Pro Leu Val Pro Pro  Gly Gly Ser 
    2450                 2455                 2460             


Pro Arg  Ala Ser Val Ser Pro  Ser Val Leu Glu Glu  Leu Leu Arg 
    2465                 2470                 2475             


Ile Gln  Thr Ala Met Ser Gln  Leu Ala Ile Gly Thr  Ala Ile Cys 
    2480                 2485                 2490             


Val Arg  Val Lys Ala Leu Leu  Gly Leu Pro Ala Gly  Ala Glu Gln 
    2495                 2500                 2505             


His Ile  Arg Gly Val Val Thr  Arg Asn Ala Leu Lys  Phe Pro Trp 
    2510                 2515                 2520             


Glu Lys  Pro Ala Ala Pro Gln  Val Gln Ala Ala Gly  Pro Ser Val 
    2525                 2530                 2535             


Gly Ala  Ser Arg Thr Ser Pro  Ser Arg Arg Leu Ser  Gly Gly Val 
    2540                 2545                 2550             


Leu Pro  Gly Asp Glu Ala Gly  Glu Arg Arg Glu Lys  Gly Gly Ala 
    2555                 2560                 2565             


Arg Arg  Gly Val Ala Glu Gly  Asp Thr Glu Lys Lys  Glu Asp Glu 
    2570                 2575                 2580             


Gly Thr  Ala Leu Cys Ala Gly  Ser Arg Glu Thr Glu  Ala Asp Gly 
    2585                 2590                 2595             


Ala Gly  Tyr Leu Thr Leu Ser  Leu Asn Asn Arg Lys  Glu Glu Phe 
    2600                 2605                 2610             


Ile Leu  Ser Phe Arg Glu Val  Gln Cys Leu Val Ala  Gln Asp Asp 
    2615                 2620                 2625             


Leu Arg  Leu Val Arg Thr Arg  Ala Arg Gln Trp Val  Ser Ser Phe 
    2630                 2635                 2640             


Gly Pro  Gln Pro Ser Ala Asp  Arg Lys Gly Glu Arg  Glu Glu Glu 
    2645                 2650                 2655             


Lys Glu  Thr Gly Gly Arg Thr  Arg Lys Phe Val Val  Asp Glu Asp 
    2660                 2665                 2670             


Phe 
    


<210>  10
<211>  2282
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Ser Gly Arg Asp Val Lys Asp Gly Thr Ala Gly Ser Arg Pro 
1               5                   10                  15      


Lys Asp Gly Gly Asp Gly Val Gly Glu Thr Arg Ala Ser Gly Arg Glu 
            20                  25                  30          


Ser Glu Glu Arg Ser Leu Gln Leu Glu Ala Asn Glu Cys Pro Gly Ala 
        35                  40                  45              


Val Met Ser Arg Arg Glu Asp Glu Ala Glu Pro Gln Ser Ser Pro Ser 
    50                  55                  60                  


Ser Ser Pro Pro Arg Glu Glu Gly Pro Gln Asn Val Asp Asp Ala Asp 
65                  70                  75                  80  


Thr Ala Asn Gly Ser Gly Glu Ala Gly Leu Gln Arg Pro Pro Gln Lys 
                85                  90                  95      


Arg Arg Leu Glu Gln Gly Leu Glu Ala Glu Ala Gly Val Gly Ser Ser 
            100                 105                 110         


Arg Val Glu Glu Val Glu Ala Val Cys Arg Lys Arg Pro Ala Phe Ser 
        115                 120                 125             


Gly Val Ala Asp Ala Phe Leu Glu Arg Pro Val Thr Leu Lys Asn Ser 
    130                 135                 140                 


Ser Glu Glu Asp Ala Ala Arg Leu Ser Gly Asp Asp Ala Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Leu Ser Val Arg Ser Ala Gly Ala Leu Thr Gly Asp Phe Pro 
                165                 170                 175     


Ser Ser Ser Ser Arg Leu Pro Ala Met Leu Ser Gly Ala Arg Gly Glu 
            180                 185                 190         


Asn Ala Glu Glu Ser Val Arg Asp Ala His Thr Pro Ala Gln Asp Ser 
        195                 200                 205             


Arg Asp Ser Ala Leu Ala Ser Phe Ala Pro Thr Leu Ala Pro Gly Gln 
    210                 215                 220                 


Glu Ser Glu Tyr Thr Arg Ala Lys Leu Trp Ser Ile Glu Lys Ala Phe 
225                 230                 235                 240 


Asp Ala Phe Leu Ala Asp Gln Lys Ala Asn Gly Arg Arg Gln Gly Ser 
                245                 250                 255     


Arg Ser Met Arg Glu Pro Ser His Ala His Pro Gly Leu Ser Ala Glu 
            260                 265                 270         


Arg Glu Thr Ser Ser Gly Ala Ser Ala Ala Thr Ser Asp Leu Ser Arg 
        275                 280                 285             


Glu Asp Val Glu Glu Leu Phe Arg Gln His Gly Val Ser Pro Arg Glu 
    290                 295                 300                 


Leu Val Arg Met Leu Ser Gly Arg Arg Asp Gly Pro Gly Thr Ser Pro 
305                 310                 315                 320 


Glu Glu Leu Arg Ala Ala Val Ala Trp Ala Arg Gln Leu Phe Pro Ala 
                325                 330                 335     


Ala Pro Arg Ser Pro Ser Glu Leu Arg Met Tyr Leu Gln Arg Ala Val 
            340                 345                 350         


Leu Asp Arg Gln Lys Arg Leu Arg Glu Arg Trp Gly Ala Glu Ala Asn 
        355                 360                 365             


Pro Cys Gly Asp Ala Ser Val Tyr Gly Asp Glu Lys Leu Arg Glu His 
    370                 375                 380                 


Leu Ser Asp Leu Ser Ala Phe Met Pro His Leu Asp Ala Gly Arg Glu 
385                 390                 395                 400 


Val Tyr Met Gln Trp Gln Arg Ser Arg Gly Arg Arg Asp Phe Asp Ala 
                405                 410                 415     


Phe Val Arg Pro Pro Gly Leu Thr Pro Phe Arg Asp Ser Ser Ser Arg 
            420                 425                 430         


Gln Gly Asp Phe Ala Ala Ser Pro Leu Tyr Ser Phe Ser Ser Arg Thr 
        435                 440                 445             


Pro Trp Ala Ser Ala Cys Lys Glu Ala Ser Thr Pro Pro Ala Ala Lys 
    450                 455                 460                 


Gln Gln Ala Pro Pro Pro Ser Leu Trp Asn Leu Pro Asn Arg Pro Gln 
465                 470                 475                 480 


Pro Tyr Thr Leu Ala Asp Val Gln Glu Ala Met Glu Gly Pro Glu Gly 
                485                 490                 495     


Val Leu Arg Val Ala Arg Pro Leu Thr Gly Phe Gly Glu Asp Ala Glu 
            500                 505                 510         


Ser Leu Ser Phe Ala Ser Leu Pro Lys Gly Ala Glu Thr Leu Phe Trp 
        515                 520                 525             


Ser Ser Gly Arg Gly Leu Tyr Phe Leu Arg His Leu Glu Arg Thr Lys 
    530                 535                 540                 


Ala Gly Glu His Asp Val Val Gly Glu Ala Gly Val Trp Val Ala Ala 
545                 550                 555                 560 


Ser Glu Glu Glu Phe Gly Gly Phe Ile Ile His Arg Lys Phe Ser Val 
                565                 570                 575     


Ala Lys Phe Gly Phe Glu Arg Ala Lys Met Leu Ala Cys Arg Trp Tyr 
            580                 585                 590         


Asn Asp Arg Gln Glu Ala Arg Arg Gly Gln His Ala Leu Pro His Arg 
        595                 600                 605             


Glu Lys Pro Lys Gly Ile Met Ser Ser Asp Arg Pro Leu Ser Arg Glu 
    610                 615                 620                 


Ala Ala Pro Glu Ala Ser Arg Phe Ser Ala Ser Arg Ala Gly Glu Leu 
625                 630                 635                 640 


Ser Gly Lys Ala Gln Glu Ala Pro Lys Ser Thr Gly Gly Thr Ala Ala 
                645                 650                 655     


Glu His Pro Arg Ala Ser Gln Lys Cys Arg Val Met Asp Thr Thr Cys 
            660                 665                 670         


Pro Val Pro Gly Val Arg Tyr Asp Ser Arg Asp Arg Ala Trp Leu Ala 
        675                 680                 685             


Thr Trp His Asp Gly Val Arg Gln Tyr Lys Arg Cys Phe Ser Ile Lys 
    690                 695                 700                 


Lys Tyr Gly Phe Ala Lys Ala Lys Glu Cys Ala Ile Arg Met Lys Met 
705                 710                 715                 720 


Ser Leu Val Gly Gln Pro Gly Val Ser Gln Ser Gly Arg Gln Ala Pro 
                725                 730                 735     


Phe Pro Val Arg Pro Phe Thr Ser Arg Ala Cys Ser Pro Leu Gln Asp 
            740                 745                 750         


Phe Phe Arg Glu Gly Asp Arg Arg Val Ala Ala Ser Ser Phe Ser Leu 
        755                 760                 765             


Leu Pro Ser Gly Arg Gly Glu Pro Arg Gly Ser Leu Gly Ser Ser Gln 
    770                 775                 780                 


Gly Ala Asp Asp Glu Arg Ser Lys Pro Gln Ser Cys Arg Gly Leu Val 
785                 790                 795                 800 


Glu Gln Leu Leu Ala Arg Phe Gln Asp Ser Glu Gly Phe Thr Arg Gly 
                805                 810                 815     


Leu Pro Gly Asp Asp Glu Asn Arg Gly Lys Arg Leu Ser Lys Gln Ala 
            820                 825                 830         


Gln Asp Asp Phe Gln Ser Trp Arg Pro Pro Pro Gly Ala Arg Phe Gly 
        835                 840                 845             


Ser Ala Ala Gln Ala Ser Arg His Ser Thr Asp Glu Val Gly Gly Phe 
    850                 855                 860                 


Ala Gly Phe Pro Gly Phe Ala Ala Ser His Cys Gly Glu Lys Pro Gly 
865                 870                 875                 880 


Gly Glu Gly Pro Ser Phe Leu Gln Lys Ser Gly Phe Val Gln Glu Asn 
                885                 890                 895     


Ala Phe Ser Pro Pro Ser Glu Arg Phe Glu Thr Gly Val His Arg Arg 
            900                 905                 910         


Val Pro Ser Leu Ser Ser Glu Leu Ala Asn Pro Gln Val Thr Glu Glu 
        915                 920                 925             


Val Glu Glu Phe Leu Phe Ser Leu Ser Thr Arg Ala Arg Gln Ser Leu 
    930                 935                 940                 


Leu Ala Ser Leu Arg Arg Gly Ala Glu Asp Ser Arg Arg Ser Ala Trp 
945                 950                 955                 960 


Pro Gly Ala Ser Arg Asp Cys His Thr Gly Ala Gly Thr Pro Gly Gly 
                965                 970                 975     


Thr Asp Val Ala Asp Arg Arg Ala Thr Arg Glu Thr Arg Arg Asp Arg 
            980                 985                 990         


Glu Gly Glu Glu Ser Thr Ser Glu  Asp Gly Thr Val Arg  Arg Glu Thr 
        995                 1000                 1005             


Asp Ala  Gly Ala Val Ser Pro  Asp Glu Val Ser Arg  Ala Asn Ala 
    1010                 1015                 1020             


Glu Glu  Arg Ala Ala Gly Glu  Lys Thr Arg Ser Ser  Glu Arg Ile 
    1025                 1030                 1035             


Trp Thr  Gly Glu Gly Glu Arg  Ser Ala Gly Asp Arg  Asp Asp Lys 
    1040                 1045                 1050             


Gly Glu  Gly Glu Gly Gly Gly  Gly Val Val Glu Gly  Arg Thr Glu 
    1055                 1060                 1065             


Lys Gly  Gly Asp Asp Asp Lys  Lys Pro Gly Glu Glu  Glu Ser Ala 
    1070                 1075                 1080             


Glu Arg  Glu Glu Glu Leu Lys  Asn Asp Ala Tyr Ala  Tyr Phe Thr 
    1085                 1090                 1095             


His Leu  Thr Asn Arg Glu Trp  Asp Leu Leu Asp Tyr  Leu Asp Thr 
    1100                 1105                 1110             


Leu Asp  Phe Glu Thr Val Asp  Leu Asp Ala Val Met  Pro Phe Ile 
    1115                 1120                 1125             


Asn Gln  Val Pro Lys Val Arg  Gly Val Cys Phe Asp  Arg Lys Gly 
    1130                 1135                 1140             


Leu Tyr  Trp Ile Ser Gln Trp  His Ser Gln Gln Lys  Lys His Arg 
    1145                 1150                 1155             


Glu Trp  Phe Gly Val Lys Arg  Leu Gly Phe Arg Lys  Ala Trp Ala 
    1160                 1165                 1170             


Leu Ala  Val Cys Val Arg Arg  Asp Ala Glu Lys Val  Glu Asp Glu 
    1175                 1180                 1185             


Pro Val  Asp Tyr Pro Lys Leu  Pro Asp Tyr Glu Glu  Val Leu Gly 
    1190                 1195                 1200             


Val Thr  Tyr Ala Arg Phe Ala  Ser Gly Arg Tyr Trp  Val Ala His 
    1205                 1210                 1215             


Tyr Met  Arg Pro Ala Ala Pro  Ser Ser Gly Cys Leu  Gly Ser Val 
    1220                 1225                 1230             


Gly Arg  Lys Leu Phe Pro Val  Ser Glu Ser Ser Phe  Glu Glu Ala 
    1235                 1240                 1245             


Arg Ser  Gln Ala Val Ala Val  Ala Thr Ala Phe Pro  Leu Pro Leu 
    1250                 1255                 1260             


Ala Phe  Phe Val Asp Pro Glu  Arg Arg Ala Thr Ser  Ala Phe Glu 
    1265                 1270                 1275             


Ser Ala  Arg Ala Glu Asn Leu  Gln Gly Asp Lys Gln  Val Leu Leu 
    1280                 1285                 1290             


Ser Lys  Asn Cys Leu Phe Asn  Val Phe Thr Trp Leu  Asn Gly Gly 
    1295                 1300                 1305             


Ala Ser  Trp Thr Asn Val Arg  Arg Trp Ala His Ala  Lys Arg Met 
    1310                 1315                 1320             


Gln Leu  Ala Glu Asp Asp Trp  Pro Gln Gln Phe Phe  Ser Leu Pro 
    1325                 1330                 1335             


Ser Pro  Ala Lys Gly Asp Ser  Phe Ala Glu Ala Glu  Lys Glu Arg 
    1340                 1345                 1350             


Ala Glu  Glu Arg Thr Gly Gly  Glu Glu Val Lys Ala  Asn Ser Ala 
    1355                 1360                 1365             


Ser Arg  Ala Ala Ala Lys Ser  Glu Trp Pro Val Ala  Ser Thr Thr 
    1370                 1375                 1380             


Ser Pro  Ala Glu Asp Leu Ala  Ser Ser Gly Ser Pro  Arg Asp Leu 
    1385                 1390                 1395             


Gln Lys  Leu Ser Pro Leu Leu  Ala Asp Ser Ser Leu  Thr Lys Glu 
    1400                 1405                 1410             


Leu Leu  Gly Gly Asp Arg Glu  Leu Gly Asn Ala Met  Asp Gly Ala 
    1415                 1420                 1425             


Arg Gly  Pro Arg Gly Leu Asp  Thr Ala Lys Gly Arg  Ala Lys Asp 
    1430                 1435                 1440             


Glu Glu  Arg Leu Thr Ala Lys  Asp Ala Glu Ser Arg  Gln Ala Thr 
    1445                 1450                 1455             


Leu Pro  Gly Gly Arg Ala Ala  His Gly Gly Gly Val  Gly Gly Ser 
    1460                 1465                 1470             


Leu Gly  Thr Ala Cys Glu Glu  Glu Leu Asp Glu Pro  Leu Ser Pro 
    1475                 1480                 1485             


Leu Asp  Ile Glu Ser Ile Val  Ala Asp Ala Tyr Glu  Ser Phe Ser 
    1490                 1495                 1500             


Asp Glu  Asp Ala Glu Gly Glu  Gly Asp Gly Gly Lys  Pro Gly Lys 
    1505                 1510                 1515             


Arg Ile  Arg Leu Pro Lys Ile  Gly Gly Val Tyr Tyr  Lys Arg Asp 
    1520                 1525                 1530             


Gly Asn  Tyr Lys Ala Trp Ala  Ala Ser Trp His Ile  Gln Gly Lys 
    1535                 1540                 1545             


Arg Thr  Arg Arg Tyr Phe Thr  Val Lys Lys His Gly  Phe Arg Asn 
    1550                 1555                 1560             


Ala Tyr  Leu Lys Ala Val Arg  Ala Arg Arg Glu Ala  Glu Arg His 
    1565                 1570                 1575             


Glu Gly  Ile Ser Val Lys His  Arg His His Ala Leu  Val Pro Gly 
    1580                 1585                 1590             


His Pro  Gly Asn Met Leu Gly  Ala Ser Lys Val Cys  Ala Glu Ser 
    1595                 1600                 1605             


His Glu  Val Ser Gly Phe Pro  His Gly Asp Glu Asp  Ser Arg Leu 
    1610                 1615                 1620             


Thr Arg  Gly Gly Ala Ser His  Ala Ala Val Ala Pro  Gly Arg Val 
    1625                 1630                 1635             


Asn Arg  Glu Arg Ser Val Ala  Leu Val Asp Arg Ala  Thr Lys Asp 
    1640                 1645                 1650             


Asp Glu  Asp Asp Glu Arg Asp  Leu Gln Arg Glu Lys  Thr Gly Ala 
    1655                 1660                 1665             


Gly Gly  Gly Glu Ala Cys Ser  Gly Glu Ser Val Lys  Val Ala Leu 
    1670                 1675                 1680             


Gly Thr  Arg His Asp Ser Phe  Ser Asp Gly Ser Cys  Arg Thr Leu 
    1685                 1690                 1695             


Asp Lys  Leu Ser Thr Gln Phe  Glu Gln Lys Pro Arg  Gly Gly Ala 
    1700                 1705                 1710             


Gly Glu  Glu Ala Glu His Pro  Thr Arg Lys Gln Gly  Gln Glu Thr 
    1715                 1720                 1725             


Gly Gly  Val Asp Glu Pro Leu  Ser Arg Ala Ala Ser  Ile Val Gly 
    1730                 1735                 1740             


Gly Arg  Glu Val Arg Leu Thr  Ser Gly Val Ser Val  His Leu Thr 
    1745                 1750                 1755             


Pro Leu  Glu Arg Val Ala Lys  Ala Val Asp Val Asp  Leu Lys Glu 
    1760                 1765                 1770             


Leu Thr  Asp Arg Val Ser Arg  Ala Ala Phe Arg Gly  Gly Asp Ser 
    1775                 1780                 1785             


Arg Leu  Phe His Arg Thr Val  Asp Asn Cys Glu Gly  Glu Ala Asp 
    1790                 1795                 1800             


Glu Val  Ala Gln Gly Leu Asp  Thr His Arg Glu Asp  Val Asp Val 
    1805                 1810                 1815             


Thr Arg  Asn Leu Glu Phe Ala  Met Ala Arg Glu Thr  Leu Asp Val 
    1820                 1825                 1830             


Leu Leu  Ser Asp Leu Tyr Ser  Val Val Ala Lys Leu  Ser Gly Ala 
    1835                 1840                 1845             


Gly Arg  Trp Thr Ser Leu Val  Ser Pro Thr Ala Ala  Glu Ala Glu 
    1850                 1855                 1860             


Pro Leu  Val Ser Ala Trp Asp  Arg Ser Ala Arg Glu  Glu Arg Arg 
    1865                 1870                 1875             


Glu Lys  Phe Glu Asp Thr Asn  Ala Ala Ser Asp Glu  Pro Gly Tyr 
    1880                 1885                 1890             


Pro Thr  Ser Ser Ala Gln Ile  His Val Ala Ile Gln  Leu Val Val 
    1895                 1900                 1905             


Ile Lys  His Tyr Leu Ala Thr  Val Arg Thr Ala Asn  Arg Val Glu 
    1910                 1915                 1920             


Gln Ile  Ala Pro Leu Leu Ala  Leu Phe Glu Pro Cys  Ile Lys Gln 
    1925                 1930                 1935             


Gly Met  Leu Pro His Glu Cys  Ala Leu Pro Arg Leu  Arg Trp Leu 
    1940                 1945                 1950             


Val Cys  Gln Leu Cys Arg Ala  Ser Leu Pro Trp Leu  Asp Glu Ser 
    1955                 1960                 1965             


Asp Val  Leu Thr Asp Ala Leu  Leu Tyr Arg His Leu  Glu Glu Leu 
    1970                 1975                 1980             


Val Glu  Thr Glu Glu Ala Glu  Ala Pro Gln Glu Gly  Val Pro Pro 
    1985                 1990                 1995             


Gly Gly  Gln Ile Val Phe Ser  Ala Gly Phe Ala Glu  Gly Asn Ser 
    2000                 2005                 2010             


Thr Val  Ala Ser Arg Asn Val  Phe Thr Gly Glu Ser  Arg Val Ala 
    2015                 2020                 2025             


Gly Gly  Phe Arg Thr Asp Ser  Glu Lys Glu Ser Gly  Ile Asp Asp 
    2030                 2035                 2040             


Arg Asp  Glu Ala Ser Leu Ala  Ala Leu Ile Cys Leu  Pro Gly Lys 
    2045                 2050                 2055             


Gly Lys  Lys Leu Arg Glu Glu  Ala Asp Val Glu Lys  Asp Asp Thr 
    2060                 2065                 2070             


Ser Ala  Ser Leu Asn Cys Glu  Ser Gly Lys Lys Thr  Glu Ala Glu 
    2075                 2080                 2085             


Ser Gln  His Ser Arg Ser Pro  Thr Glu Val Ala Ala  Ser Ser Val 
    2090                 2095                 2100             


Ser Gly  Ser Glu Gly Lys Asp  Gly Ser Ser Asp Asn  Glu Arg Ser 
    2105                 2110                 2115             


Gly Asp  Ala Asp Asp Ala Thr  Glu Gly Ser Glu Lys  Cys Glu Lys 
    2120                 2125                 2130             


Thr Arg  Gly Gly Asp Gln Arg  Arg Ala Ala Pro Arg  Thr Ser Ser 
    2135                 2140                 2145             


Ala Ser  Thr Ala Ser Gly Glu  Thr Pro Glu Lys Ser  Lys Asn Arg 
    2150                 2155                 2160             


Gly Ser  Asp Ala Leu Lys Gly  Lys Asn Glu Gly Gly  Ala Thr Gly 
    2165                 2170                 2175             


Thr Ser  Gly Glu Gln Arg Asp  Asp Glu Asp Arg Asp  Leu Glu Asn 
    2180                 2185                 2190             


Val Glu  Ile Ser Lys Asp Thr  Arg Ala Gly Ser Gly  Gly Arg Arg 
    2195                 2200                 2205             


Arg Thr  Gly Glu Arg Arg Gly  Gln Arg Phe Cys Ala  Ser Gly Gly 
    2210                 2215                 2220             


Glu Leu  Arg Val Ser Glu Glu  Ser Pro Asp Arg Ala  Lys Thr Glu 
    2225                 2230                 2235             


Lys Ser  Lys Gly Glu Pro Val  Arg Asp Ser Leu Ser  Pro Asp Ala 
    2240                 2245                 2250             


Ser Ser  Arg Leu Pro Ser Arg  Cys Gly Thr Pro Pro  Pro Ala Ala 
    2255                 2260                 2265             


Ala Thr  Gly Ser Cys Ala Thr  Val Glu Ser Asp Val  Pro Ala 
    2270                 2275                 2280         


<210>  11
<211>  3236
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Thr Val Ser Arg Ala His Ala Ser Arg Ser Arg Arg Lys Ser 
1               5                   10                  15      


Arg Asp Glu Asp Ser Glu Gly Ser Ser Leu Pro Ala Val Gly Ile His 
            20                  25                  30          


Glu Thr Gln Ser Pro Val Phe Ser Arg Glu Gly His Glu Gly Asp Arg 
        35                  40                  45              


Ala Ala Gln Pro Glu Asp Val Val Ala Ala Glu Ser His Ser Asn Pro 
    50                  55                  60                  


Gln Trp Pro Thr Pro Leu Asp Thr Gly Phe Asp Lys Gly Ala Pro Pro 
65                  70                  75                  80  


Leu Gly Cys Ser Arg Ser Glu Glu Leu Arg Ser Pro Pro Met Ala Ser 
                85                  90                  95      


Gly Ser Phe His Gly Ser Gly Thr Gly Gly Asp Gly Gly Cys Leu Leu 
            100                 105                 110         


Ser Leu Glu Ala His Ala Val Ser Lys Asp Ser Glu Arg Gln Val Asn 
        115                 120                 125             


Ser Gly Leu Pro Gly Gly Gly Asp Glu Ile Ser Gly Arg Leu Ser Pro 
    130                 135                 140                 


Ser Cys Ala Ser Leu Pro Leu Val Ala Ala Ala Leu Ser Pro Val Glu 
145                 150                 155                 160 


Asp Thr Arg Leu Glu Arg Asp Ser Ser Ile Pro Val Leu Lys Pro Ser 
                165                 170                 175     


Leu Ser Ile Pro Asn Leu Leu Val Thr Ser Pro Ser Leu Thr Ser Val 
            180                 185                 190         


Ser Tyr Val Cys Glu Ala Asp Arg Ser Ala Glu Gly Lys Ala Pro Ser 
        195                 200                 205             


Met Asp Ala Leu Pro Pro Ser His Ser Ala Ala Pro Glu Ser Gly Leu 
    210                 215                 220                 


Trp Arg Glu Cys Asp Glu Arg Gly Lys Asn Ser Phe Phe Ser Ser Gly 
225                 230                 235                 240 


Leu Pro Ala His Pro Glu Gly Asn Gly Glu Arg Ala Gly Glu Gly Gln 
                245                 250                 255     


Asp Pro Arg Ser Gly Asp Phe Glu Thr Pro Glu Glu Ala Ala Phe Ser 
            260                 265                 270         


Val Gln Arg Ile Leu Gln Glu Ser Glu Glu Leu Phe Leu Leu Ser Gly 
        275                 280                 285             


Cys Ala Arg Glu Asp Arg Gly Gly Glu Ser Asp Ala Ala Phe Lys Thr 
    290                 295                 300                 


Met Thr Arg Ser Glu Gly Ala Phe Ser Arg Glu Pro Ala His Arg His 
305                 310                 315                 320 


Ala Phe Ala Lys Pro Gly Asn Gly Gly Glu Ser Glu Pro Phe Met Ser 
                325                 330                 335     


Ile Asp Glu Glu Arg Ala Ala Ser Pro Ser Ala Ser Gly Pro Ser Ser 
            340                 345                 350         


Tyr Ala Phe Leu Ser Phe Glu Glu Thr Ser Ala Gly Ser Arg Arg Ser 
        355                 360                 365             


Pro Asp Ala Gln Ser Pro Pro Leu Ser Gly His Leu Ser Asp Gly Asp 
    370                 375                 380                 


Arg Thr Gln Arg Lys Ala Gly Glu Arg Phe Leu Glu Asp Pro Arg Gly 
385                 390                 395                 400 


Asn Leu Lys Arg Ser Arg Ser Pro Leu Ile Ala Arg Asp Cys Asn Arg 
                405                 410                 415     


Ser Leu Gly Thr Cys Asp Ser Ser Leu Thr Thr Arg Gly Pro Val Ala 
            420                 425                 430         


Ser Asp Thr Ser Pro Arg Arg Gly Tyr Thr Asp Gln Trp His Ser His 
        435                 440                 445             


Arg Lys Ala Gln Ser Pro Gly Arg Phe Arg Arg Thr Asn Thr Glu Gly 
    450                 455                 460                 


Asn Ala Thr Pro Val Asp Ser Gln Ser Ser Pro Pro Ser Lys Lys Arg 
465                 470                 475                 480 


Cys Cys Leu Ala Glu Arg Phe Ala Phe Glu Arg Arg Arg Gln Pro Pro 
                485                 490                 495     


Val Pro Leu Pro Ser Val Ala Ser Ala Val Ala Ala Ala Leu Ala Gln 
            500                 505                 510         


Phe Pro Pro Gly Ala Cys Thr Ala Ala Val Glu Arg Ala Asp Asp Val 
        515                 520                 525             


Pro Pro Glu Gly Ser Gly Asn Gly Val Leu Pro Gly Gly Glu Val Ser 
    530                 535                 540                 


Asp Leu Ser Leu Ser Asp Arg Lys Ser Gly Ala Ser Pro Arg Gln Thr 
545                 550                 555                 560 


Leu Asp Thr Phe Leu Pro Ala Lys Gly Ala Ser Ala Ala Leu Lys Gln 
                565                 570                 575     


Glu Gly Ser Ser Ser Glu Ile Gly Glu Gly Cys Pro Ala Ser Asp Asp 
            580                 585                 590         


Ala Ala Val Ala Ala Thr Leu Ser Gly Trp Lys Arg Gly Arg Gly Pro 
        595                 600                 605             


Arg Ser Gly Cys Val Ser Gly Ser Ser Arg Ala Ser Ser Leu Glu His 
    610                 615                 620                 


Ala Gly Ala Arg Arg Arg Ser Gly Val Glu Arg Lys Arg Arg Glu Lys 
625                 630                 635                 640 


Arg Lys Ala Ala Leu Ala Thr Ala Ala Val Val Ser Ala Ser Val Arg 
                645                 650                 655     


Arg Leu Ala Leu Val Ala Ala Pro Cys Leu Val Glu Asn Thr Leu Arg 
            660                 665                 670         


Gln Trp Trp Arg Leu Gln Glu Gln Val Gly Asp Glu Leu Asp Asn Gly 
        675                 680                 685             


Gly Val Ser Glu Glu Gln Thr Thr Gly Arg Ser Gly Arg Arg Thr Gly 
    690                 695                 700                 


Lys Asn Pro Ile Val Gly Gly Arg Val Lys Glu Gly Glu Gln Ser Val 
705                 710                 715                 720 


Arg Leu Glu Ile Glu Arg Ser Gly Asp Ser Pro Arg Asn Thr Ala Lys 
                725                 730                 735     


Thr Glu Pro Gly Asp Gln Gly Ala Ala Gln Gly Gln Gly Gly Pro Glu 
            740                 745                 750         


Gln Ile Ala Glu Asn Glu Ser Gly Thr Glu Arg Met Glu Thr Ser Gln 
        755                 760                 765             


Thr Lys Gln Glu Ala Gln Asp Leu Pro Leu His Arg Glu Ala Ala Ser 
    770                 775                 780                 


Ala Ser Ala Thr Pro Phe Ile Pro Glu Gly Arg Thr Gln Glu Arg Asp 
785                 790                 795                 800 


Ser Tyr Leu Arg Val Thr Leu Phe Ala Ala Ser Gln Val Leu Asn Ser 
                805                 810                 815     


Gly Gln Phe Arg Gln Ala Ile Arg Met Phe Pro Gly Ala Asp Ser Pro 
            820                 825                 830         


Arg Gly Asp Gln Arg Ser Arg Cys Val Val Arg Val Tyr Lys Gln Ser 
        835                 840                 845             


Leu Arg Lys Arg Arg Leu Ser Gly Asp Arg Asn Arg Arg Val Gly Glu 
    850                 855                 860                 


Asp Gly Asn Leu Val Ser Val Ser Leu Arg Asp Leu Leu Ala Asn Ser 
865                 870                 875                 880 


Gly Glu Asp Trp Glu Pro Ser Ser Pro Ser Ala Ala Thr Arg Pro Leu 
                885                 890                 895     


Pro Leu Ala Pro Ser Ala Leu Ser Ala His Gln Ala Arg Ser Ser Phe 
            900                 905                 910         


Gly Ser Phe Ser Arg Arg Ser Ala Glu Gly Val Pro Gly Pro Ser Pro 
        915                 920                 925             


Trp Gly Gly Asp Cys Ser Pro Thr Ala Ala Arg Ser Pro Leu Pro Leu 
    930                 935                 940                 


Ser Thr Ser His Asp Leu Arg Arg Arg Arg Val Cys Pro Pro Arg Arg 
945                 950                 955                 960 


Arg Tyr Ser Pro Ser Glu Ser Val His Ser Ser Asp Gly Arg Gly Gly 
                965                 970                 975     


Ala Cys Ala Ile Ala Ala Lys Lys Pro Lys Gly Arg Arg Ser Arg Gly 
            980                 985                 990         


Arg Glu Glu Gln Thr Arg Glu Glu  Val Ser Glu Ser Arg  Cys Ser Thr 
        995                 1000                 1005             


Pro Arg  Ser Cys Ser Ser Val  Arg Tyr Ala Val Ser  Asp Gly Ser 
    1010                 1015                 1020             


Pro Ala  Ser Ser Arg Ala His  Leu Gly Arg Pro Asp  Asp Glu Gly 
    1025                 1030                 1035             


Asp Glu  Arg Met Thr Gly Gly  Gln Arg Thr Pro Arg  Gly Thr Pro 
    1040                 1045                 1050             


Gln Glu  Gly Glu Asp Ser Asp  Phe Leu Pro Ala Gly  Met Ser Gly 
    1055                 1060                 1065             


Leu Arg  Gly Gly Thr Leu Pro  Leu Asp Gln Leu Gly  Glu Arg Ser 
    1070                 1075                 1080             


Arg Ser  Ala Glu Arg Trp Met  Pro Ala Pro Ser Val  Ala Val Val 
    1085                 1090                 1095             


Pro Phe  Ala Pro Asn Ile Leu  Ala Lys Lys His Ala  Glu Asp Val 
    1100                 1105                 1110             


Glu Asn  Gln Leu Asp Gly Gly  Lys Met Ser Leu Asp  Gly Val Gly 
    1115                 1120                 1125             


Gln Lys  Glu Cys Gly Leu Val  Glu Thr Gly Asp Thr  Gly Glu Gln 
    1130                 1135                 1140             


Glu Ala  Ala Val Ala Ala Ser  Glu Lys Arg Arg Pro  Leu Glu Ala 
    1145                 1150                 1155             


Gln Thr  Pro Gly Arg His Gly  Thr Thr Val Leu Met  Lys Gly Glu 
    1160                 1165                 1170             


Gly Leu  Leu Ala Gly Arg Thr  Ser Glu Val Asp Gly  Asp Arg Thr 
    1175                 1180                 1185             


Gly Glu  Lys Thr Thr Gln Ile  Ser Pro Phe Ser Glu  Ala Thr Gly 
    1190                 1195                 1200             


Ile Cys  Ile Leu Arg Arg Ser  Pro Arg Arg Val Gln  Ser Asn Ser 
    1205                 1210                 1215             


Ser Glu  Ala Ser Arg Thr Ala  Val Arg Ser Thr Glu  Gly Leu Glu 
    1220                 1225                 1230             


Thr Ser  Asp Lys Leu Gly Val  Asp Val Gly Thr Thr  Asn Lys Glu 
    1235                 1240                 1245             


Ala Asp  Ser Phe Ser Ala Ser  Cys Asp Ser Pro Arg  Asp Ser Leu 
    1250                 1255                 1260             


Glu Arg  Asn Val Gly Glu Ile  Val Ala Ile Trp Ala  Arg Ala Arg 
    1265                 1270                 1275             


Asp Ala  Lys Gln Gly Gly Arg  Ile Arg Arg Arg Val  Trp Leu Pro 
    1280                 1285                 1290             


Pro Gly  Met Ala Thr His Gly  Gly His Glu Gly Asn  Glu Gln Asn 
    1295                 1300                 1305             


Asn Glu  Ala Ile Cys Gly Gly  Gly Ala Thr Pro Met  Met Lys Thr 
    1310                 1315                 1320             


Glu Arg  Ala Met Glu Glu Gly  Arg Gly Asp Ala Lys  Thr His Pro 
    1325                 1330                 1335             


Val Gly  Gly Thr Tyr Ala Glu  Thr Glu Lys Lys Val  Val Asp Glu 
    1340                 1345                 1350             


Met Lys  Ala Trp Trp Ser Lys  Leu Thr Cys Ala Ser  Val Glu Ala 
    1355                 1360                 1365             


Val Pro  Val Gln Thr Leu Thr  Leu Asp Asp Phe Ala  Arg Ala Phe 
    1370                 1375                 1380             


Ser Thr  Val Ala Asn Arg Ala  Val Asp Leu Leu Cys  Leu Ala Phe 
    1385                 1390                 1395             


Arg Ala  Arg Gly Ala Gly Pro  Val Phe Arg Pro Val  Leu Ser Ser 
    1400                 1405                 1410             


Ser Pro  Lys Gln Gln Gly Asn  Ser Pro Gln Pro Glu  Ser Glu Asp 
    1415                 1420                 1425             


Val Glu  Thr Arg Ile Glu Thr  Tyr Arg Gln Gln Val  Arg Arg Leu 
    1430                 1435                 1440             


Tyr Arg  Arg Arg Gln Gln Leu  His Glu Ala Thr Gly  Asn Ser Pro 
    1445                 1450                 1455             


Phe Ser  Ser Ser Arg Val Gly  Gly Ala Leu Gln Arg  Arg Ile Gly 
    1460                 1465                 1470             


Glu Leu  Gln Arg Leu Arg Glu  Ala His Gly Arg Val  Asp Ile Pro 
    1475                 1480                 1485             


Asn Glu  Gly Pro Arg Arg Glu  Glu Asp Ser Glu Lys  Cys Pro Ala 
    1490                 1495                 1500             


Ser Leu  Trp Asp Val Pro Leu  Arg Gln Arg Lys Gln  Gly Arg Lys 
    1505                 1510                 1515             


Arg Val  Ser Pro Trp Tyr Ser  Val Gly Val Arg Trp  Leu Ala Asp 
    1520                 1525                 1530             


Phe Ser  Ala Phe Glu Tyr Phe  Val Val Lys Asn Tyr  Arg Lys Glu 
    1535                 1540                 1545             


Asp Leu  Gly Ala Thr Val Ser  Leu Ser Asn Arg Gly  Glu Ala Ser 
    1550                 1555                 1560             


Asp Thr  Thr Trp Ser Val Asp  Gly Thr Gly Ser Gln  Arg Ala Pro 
    1565                 1570                 1575             


Val Pro  Cys Leu Ser Arg Ala  Gly Thr Pro Arg Thr  Val Ser Pro 
    1580                 1585                 1590             


Ser Pro  Pro Ser Ala Asp Ala  Met Asn Leu Trp Ala  Gln Ala Tyr 
    1595                 1600                 1605             


Ala Pro  Ser Leu Asn Gln Pro  Arg Gly Met Ser Pro  Ala Thr Thr 
    1610                 1615                 1620             


Pro Pro  Leu Ser Glu Ser Ala  Thr Pro Arg Gly Asn  Val Ser Pro 
    1625                 1630                 1635             


Pro Phe  Ser Glu Ala Ser Ser  Ser Gly Gln Arg Gly  Lys Lys Val 
    1640                 1645                 1650             


Ala Pro  Gly Pro Ser Ala Asp  Glu Lys Lys Asp Glu  Asp Tyr Gln 
    1655                 1660                 1665             


Ser Ala  Gly Ser Leu Arg Trp  Glu Val Asp Gly Gly  Gln Arg Arg 
    1670                 1675                 1680             


Gln Val  Gln Val Arg Ser Arg  Leu Leu Leu His Glu  Leu Leu Gln 
    1685                 1690                 1695             


Pro Pro  Ser Leu Asp Ala Thr  Gly Leu Arg Thr Ala  Leu Val Leu 
    1700                 1705                 1710             


Ile Val  Leu Arg Leu Gln Arg  Phe Leu Arg Leu Lys  Glu Gly Gly 
    1715                 1720                 1725             


Val Asn  Asn Arg Gly Arg Gly  Gln Arg Ser Glu Arg  Lys Arg Arg 
    1730                 1735                 1740             


Cys Arg  Ala Met Pro Pro Ile  Phe Ile Phe Arg Asp  Asp Ser Asn 
    1745                 1750                 1755             


Ala Phe  Gln Glu Ala Leu Leu  Ala Lys Lys Leu Asp  Ile Arg Leu 
    1760                 1765                 1770             


Asp Ser  Asp Ser Pro His Thr  Asp Val Pro Ser Arg  Arg Ser Leu 
    1775                 1780                 1785             


Asp Gly  Glu Val Gly Asp Glu  Arg Arg Arg Leu Arg  Ser Val Lys 
    1790                 1795                 1800             


Pro Thr  Asn Ser Asn Asp Leu  Ser Asp Glu Arg Gly  Pro Pro Pro 
    1805                 1810                 1815             


Pro Ser  Thr Met Ser Pro His  Ser Leu Gly Ser Gly  Pro Cys Asp 
    1820                 1825                 1830             


Thr Gln  Glu Gly Val Gln Asn  Leu Gln Gln Asp Ala  Ser Leu Phe 
    1835                 1840                 1845             


Ser Pro  Ala Leu Ala Gln Gly  Gln Ala His Ala His  Thr Asp Ala 
    1850                 1855                 1860             


Val Pro  Gly Ala Arg His Asp  Asp Val Leu Pro Arg  Ser Pro Arg 
    1865                 1870                 1875             


Phe Pro  Val Val Asp Ala Gly  Pro Glu Glu Thr Pro  Arg Pro Glu 
    1880                 1885                 1890             


Val Glu  Ser Met Leu Asp Ser  Glu Ser Gly Asp Pro  Thr Gly Leu 
    1895                 1900                 1905             


Gly Gln  Ala Ser Arg Arg Arg  Trp Arg Gly Arg Gly  Ser Arg Thr 
    1910                 1915                 1920             


Ser Val  Gln Arg Thr Val Ser  Thr Cys Leu His Glu  Asp His Ser 
    1925                 1930                 1935             


Gly Asp  Lys Thr Pro Arg Glu  Glu Thr Phe Gly Gly  Asp Ala Ala 
    1940                 1945                 1950             


Ser Leu  Leu Arg Val Ala Ser  Ser Val Pro Pro Ser  Thr Cys Ser 
    1955                 1960                 1965             


Ser Pro  Gln Ser Ser Ser Gly  Gly Arg Arg Glu Arg  Gly Arg Arg 
    1970                 1975                 1980             


Gly Val  Arg Gly Arg Arg Gly  Arg Gly Arg Leu Ile  Ser Gln Gln 
    1985                 1990                 1995             


Gly Ser  Ser Leu Leu Gly Gln  Thr Val Ser Ala Gly  Ala Leu Ser 
    2000                 2005                 2010             


Ser Gly  Asp Thr Ala Gly Ala  Ile Ser Thr Glu Gly  Glu Asn Arg 
    2015                 2020                 2025             


Arg Asn  Ala Val Arg Pro Gly  Ala Leu Glu His Ser  Asp Glu Asp 
    2030                 2035                 2040             


Lys Glu  Asp Leu Ser Ala Ser  Ser Pro Pro Ser Asp  Asp Gly Ile 
    2045                 2050                 2055             


Ser Gln  Arg Ser Ser Gly Ser  Gln Gly Asp Ser Ser  Ser Ser Gly 
    2060                 2065                 2070             


Gly Pro  Ser Ser Glu Ala Cys  Arg Lys Thr Thr Ser  His Val Ala 
    2075                 2080                 2085             


Ala Lys  Ala Asp Ser Ala Ser  Pro Arg Ala Leu His  Pro Ser Ala 
    2090                 2095                 2100             


Arg Pro  Gln Pro Arg Gly Thr  Ala Ser Trp Thr Pro  Gly Gly Glu 
    2105                 2110                 2115             


Pro Ala  Val Ser Gly Val Gln  His Pro Ser Ala Leu  Thr Pro Ser 
    2120                 2125                 2130             


Pro Ser  Arg Gly Arg Phe Ser  Glu Asp Asn Val Ala  Ser Arg Val 
    2135                 2140                 2145             


Ser Arg  Val Ser Ser Val Gly  Ala Leu Leu Arg Ser  Arg Cys Val 
    2150                 2155                 2160             


Val Gly  Glu Glu Gln Lys Glu  Thr Gln Asn Ser Cys  Ser Leu Trp 
    2165                 2170                 2175             


Val Val  Glu Lys Gly Ala Leu  Glu Pro Phe Trp Trp  Arg Thr Ala 
    2180                 2185                 2190             


Ser Ala  Val Gly Cys Val Ser  Ala Gly Arg Arg Asp  His Ser Asp 
    2195                 2200                 2205             


Lys Asp  Ala Asn Arg Leu Phe  Leu Ala Asp Lys Glu  Ala Gly Thr 
    2210                 2215                 2220             


Gly Pro  Leu Gln Asp Phe Val  Leu Pro Asp Phe Ser  Gly Ser Ala 
    2225                 2230                 2235             


Arg Glu  Ile His Gly Asp Glu  Arg Gly Ser Asp Ser  Asp Ala Ser 
    2240                 2245                 2250             


Cys Lys  Ser Ala Ala Leu Ser  Thr Thr Ser Asp Ser  Ser Gly Ile 
    2255                 2260                 2265             


Ser Glu  Val Ser Leu Asp Leu  Glu Ser Thr Val Gln  Glu Val Ala 
    2270                 2275                 2280             


Leu Gly  Thr Ile Leu Ser Ser  Ala Leu Ser Ala Leu  His Gly Lys 
    2285                 2290                 2295             


Thr Gly  Asp Gly Asp Thr Gln  Glu Ser Asp Ala Glu  Arg Glu Ala 
    2300                 2305                 2310             


Asn Ala  Asp Asp Gly Ser Ala  Thr Gly Val Asn Glu  Lys Asp Leu 
    2315                 2320                 2325             


Arg Gly  Glu Ser Arg Pro Glu  Leu Pro Ser Pro Ile  Pro Gly Lys 
    2330                 2335                 2340             


Asp Glu  Leu Gly Ser Gln Glu  Glu Gly Lys Thr Ala  Ser Ser Leu 
    2345                 2350                 2355             


Pro Ser  Val Lys Ala Glu Gln  Gly Gly Ser Glu Arg  Gly Gly Ala 
    2360                 2365                 2370             


Asp Glu  Ile Val Lys Lys Ala  Thr Ser Val Leu Arg  Ala Cys Lys 
    2375                 2380                 2385             


Asp Pro  Asp Glu Ala Thr Ser  Thr Ser Leu Val Pro  Glu Gly Glu 
    2390                 2395                 2400             


Asp Glu  Asn Asp Ala Cys Gly  Ala Leu Glu Pro Asp  Ser Leu Val 
    2405                 2410                 2415             


Ser Val  Ser Ala Leu Gly Glu  Ser Ser Glu Glu Leu  Phe Thr Glu 
    2420                 2425                 2430             


Val Pro  Gln Asn Glu Lys Glu  Leu Lys Lys Thr Leu  Gln His Val 
    2435                 2440                 2445             


Asp Pro  Arg Leu Cys Gln Gln  Met Leu His Gly Gly  Leu Cys Phe 
    2450                 2455                 2460             


Ile Arg  Thr Tyr Val Asp Leu  Glu Thr Lys Lys Glu  Ser Leu Gln 
    2465                 2470                 2475             


Ala Gly  Pro Phe Ala Ala Lys  Arg Arg Arg Val Ala  Gln Leu Leu 
    2480                 2485                 2490             


Arg Gly  Leu Gln Gly Leu Phe  Asp Ala Leu Glu Ser  Val Arg Glu 
    2495                 2500                 2505             


Arg Glu  Gly Asp Asp Leu Ser  Gly Glu His Glu Gly  Asp Ser Ala 
    2510                 2515                 2520             


Ser Gly  Gly Leu Phe Thr Ala  Glu Gln Glu Lys Glu  Gly Ala Asp 
    2525                 2530                 2535             


Lys Val  Ser Gly Asp Arg Glu  Asn Ala Gly Glu Arg  Gly Gln Lys 
    2540                 2545                 2550             


Thr Ala  Ala Glu Thr Gly Asp  Gln Lys Ala Ser Ile  Glu Asp Ala 
    2555                 2560                 2565             


Val Ala  Ala Ala Phe Cys Arg  Arg Val Gly Ala Ala  Ile Ala Thr 
    2570                 2575                 2580             


Glu Thr  Cys Gly Ser Ile Gln  Thr Val Phe Pro Glu  Ile Gly Glu 
    2585                 2590                 2595             


Ala Tyr  Asp Val Glu Asp Ser  Val Ala Arg Leu Gly  Ala Pro Pro 
    2600                 2605                 2610             


Arg Ala  Pro Val Arg Thr Arg  Arg Glu Cys Thr Gly  Thr Gly Phe 
    2615                 2620                 2625             


Thr Ser  Thr Ala Ala Leu Pro  Glu Pro Arg Gly Glu  Asp Gly Arg 
    2630                 2635                 2640             


Lys Gln  Glu Thr Ser Glu Pro  Leu Gly Val Glu Ala  Ala Asp Lys 
    2645                 2650                 2655             


Thr Asp  Ile Gln Gly Glu Tyr  Ala Gln Glu Ser Glu  His Thr Trp 
    2660                 2665                 2670             


Thr Gln  Glu Met Gly Arg Lys  Ala Ser Leu Phe Leu  Ser Gly Thr 
    2675                 2680                 2685             


Leu Glu  Leu Ala Gln Leu Lys  Glu Glu Gln Gln Val  Glu Glu Leu 
    2690                 2695                 2700             


Gln Gly  Glu Gly Asp Pro Leu  Thr Ser Phe Leu Leu  Pro Ser Asp 
    2705                 2710                 2715             


Gln Ser  Asp Ser Thr Lys Lys  Ala Asn Glu Glu Cys  Met Gly Gly 
    2720                 2725                 2730             


Arg Thr  Ala Arg Glu Leu Tyr  Ala Glu Arg Glu Glu  Asp Val Lys 
    2735                 2740                 2745             


Thr Leu  Gly Arg Arg Arg Glu  Ala Gln Thr Glu Ser  Arg Ala Arg 
    2750                 2755                 2760             


Gly Pro  His Val Asp Ser Ser  Ala Glu Ala Ala Ser  Val Ala Gln 
    2765                 2770                 2775             


Gly Asp  Glu Gly Gly Glu Glu  Ala Arg Lys Arg Lys  Lys Asp Glu 
    2780                 2785                 2790             


Lys Arg  Glu Lys Arg Ser Gly  Asn Ala Phe Leu Asp  Ala Leu Leu 
    2795                 2800                 2805             


Glu Pro  Ala Leu Arg Glu Asp  Val Gly Arg Ala Phe  Leu Thr Asp 
    2810                 2815                 2820             


Phe Gly  Ser Gln Ala Pro Gln  Asn Ser Thr Asp Ala  Gly Lys Pro 
    2825                 2830                 2835             


Ile Phe  Leu Ser Pro Cys Val  Phe Gly Val Arg Gly  Gly Ala Arg 
    2840                 2845                 2850             


Trp Lys  Lys Leu Gly Leu Phe  Asn Asp Glu Ala Gln  Arg Glu Gly 
    2855                 2860                 2865             


Thr Glu  Ser Ser Pro Trp Arg  Asn Asp Cys Ser Asp  Pro Met Ser 
    2870                 2875                 2880             


Tyr Arg  Ala Asp Ala Pro His  Thr Trp Arg Arg His  Glu Gly Leu 
    2885                 2890                 2895             


Leu Trp  Gly Gly Ser Arg His  Ala Ala Ser Ala Leu  Arg His His 
    2900                 2905                 2910             


Gly Arg  Lys Ser Pro Ala Phe  Leu Ser Pro Gln Trp  Glu Asp Asp 
    2915                 2920                 2925             


Glu Arg  Leu Ser Leu Ser Ser  Ser Ala Asp Glu Arg  Gly Tyr Thr 
    2930                 2935                 2940             


Ser Ser  Gly Ser Glu Arg Phe  Leu Ser Ile Pro Thr  Arg Arg Lys 
    2945                 2950                 2955             


Tyr Gly  Leu Arg Phe Gln Arg  Arg Ser Thr Lys Thr  Gly Arg Ala 
    2960                 2965                 2970             


Pro Ser  Pro Thr Ala Gly Arg  Ser Ser Val Asn Arg  Ser Gly Trp 
    2975                 2980                 2985             


Arg Glu  Thr Leu Arg Pro Ser  Ser Gly Phe Ser Gly  Glu Glu Thr 
    2990                 2995                 3000             


Pro Arg  Ser Leu Ser Ser Arg  Arg Arg Arg Gly Gly  Leu Gly Gly 
    3005                 3010                 3015             


Ser Ser  Pro Thr Ala Phe Arg  Pro Pro Met Thr Arg  Ala Ala Thr 
    3020                 3025                 3030             


Gly Lys  Ala Ala Ala Cys Val  Arg His Gly Asp Gly  Asp Glu Cys 
    3035                 3040                 3045             


Ala Glu  Pro Asp Ser Gln Phe  Gly Ala Phe Gly Ser  Ala Asp Leu 
    3050                 3055                 3060             


Gly Leu  Ser Asp Arg Arg Gly  Glu Ala Gly Glu Ala  Asp Thr Arg 
    3065                 3070                 3075             


Glu Glu  Lys Ala Gly Gly Ser  Ala Arg His Gly Lys  Arg Gly Ser 
    3080                 3085                 3090             


Gly Val  Arg Ser Gly Gly Ala  Arg Glu Ala Gly Ser  Asp Ala Gly 
    3095                 3100                 3105             


Thr Asp  Thr Leu Trp Val Ala  Pro Gly Ser Gly Pro  Asn Thr Cys 
    3110                 3115                 3120             


Arg Ser  Gly Arg Lys Ser Pro  Ala Ala Ala Ala Leu  Ser Ser Leu 
    3125                 3130                 3135             


Pro Thr  Gly Val Tyr Phe Asp  Ala Ser Arg Lys Leu  Trp Arg Cys 
    3140                 3145                 3150             


Gln Trp  Arg Glu Asn Gly Arg  Phe Lys Thr Lys Gly  Phe Ser Leu 
    3155                 3160                 3165             


Asn Val  Tyr Lys Thr Leu Lys  Glu Ala Arg Arg Ala  Cys Val Val 
    3170                 3175                 3180             


Tyr Arg  Cys Leu Met Gly Gly  Trp Glu Val Asp Pro  Arg Trp Leu 
    3185                 3190                 3195             


Gly Pro  Asp Asp Asp Glu Gln  Asp Asn Ser Gly Gly  Ala Asp Glu 
    3200                 3205                 3210             


Val Gly  Arg Pro Val Pro Ser  Asp Gly Ile Ser Asp  Val Val Gly 
    3215                 3220                 3225             


Glu Ala  Arg Arg Lys Gly Glu  Tyr 
    3230                 3235     


<210>  12
<211>  1670
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ile Asn Leu His Gln Leu Phe Arg Val Phe Ser Arg Val Ser Ser 
1               5                   10                  15      


Ser Ala Ser Asp Pro Ser Ala Ser Asn Pro Ser Pro Ala Ser Leu Val 
            20                  25                  30          


Ser Val Pro Ala Leu Gln Thr Leu Ser Phe Pro Ala Leu Gln Gln Gln 
        35                  40                  45              


Asp Leu Leu Ala Ser Leu Ala Ala Ala Ser Leu Pro Gly Pro Asp Ser 
    50                  55                  60                  


Val Thr Met Ser Ser Ser Pro Thr Ser Val Leu Asn Ser Ser Phe Cys 
65                  70                  75                  80  


Ser Leu Pro Ser Ser Arg Lys Pro Ala Ala Leu Pro Phe Pro Ala Thr 
                85                  90                  95      


Ser Pro Lys Thr Pro His Leu Ser Asp Ser Phe Pro Ala Ser Ala Ile 
            100                 105                 110         


Ser Gly Pro Ser Ser Pro Gly Leu Gln Glu Leu Leu Ala Ser Pro Glu 
        115                 120                 125             


Leu Ala Ala Ala Ala Leu Ala Ser Leu Gln Lys Gln Gln Leu Arg Leu 
    130                 135                 140                 


Ala Leu Gly Thr Glu Arg Gly Gly Cys Gly Ala Arg Gly Asp Glu His 
145                 150                 155                 160 


Leu His Ser Ile Leu Leu Gln His Lys Ala Thr Ser Glu Asn Ala Met 
                165                 170                 175     


Arg Trp Ser Trp His Ala Gly Arg Asp Gly Ala Gln Glu Leu Asp Thr 
            180                 185                 190         


Val Pro Glu Thr Phe Asp Leu Pro Leu Ser Leu Ser Ser Phe Leu Gly 
        195                 200                 205             


Val Ala Pro Gln Gln Pro Ser Ser Leu Pro Arg Ser Ser Leu Leu Pro 
    210                 215                 220                 


Pro Thr Asp Phe Ser Leu Thr Asp Gly Thr Leu Arg Val Ser Ser Ser 
225                 230                 235                 240 


Met Leu Pro Ala Leu Ala Thr Gly Ser Glu Ser Gly Ser Ser Arg Gly 
                245                 250                 255     


Leu Asn Ser Ala Gln Ala Ser Pro Ser Phe Ser Ser Leu Arg Gly Pro 
            260                 265                 270         


Pro Val Ser Val Pro Glu Glu Glu Val Ser Gly Ser Leu Glu Gly Ser 
        275                 280                 285             


Pro Gly Pro Phe Ser Ser Gly His Pro Pro Ala Ala Pro Ser His Pro 
    290                 295                 300                 


Cys Ser Thr Val Ser Gly Ala Asp Thr Gln Glu Ala Glu Pro Pro Leu 
305                 310                 315                 320 


Leu Thr Leu Val Ala Val Asn Thr Pro Asp Ala Gln Asp Pro Ala Val 
                325                 330                 335     


Asp Gly Ala Ser Leu Cys Ala Ser Lys Glu Gly Met Arg Thr Ser Ser 
            340                 345                 350         


Ala Asp Leu Gly Asp Ser Leu Leu Ala Pro Pro Gly His Gly Ser Ala 
        355                 360                 365             


Ala Pro Leu Pro Gly Arg His Leu Gly Ser Asp Ala Thr Arg Thr Thr 
    370                 375                 380                 


Thr Thr Thr Gly Ser Gly Ala Pro Glu Ser Pro Ser Leu Pro Leu Ala 
385                 390                 395                 400 


Arg Gly Asp Cys Glu Gly Ala Glu Arg Gly Leu Ala Leu Leu Glu Ala 
                405                 410                 415     


Pro Val Asn Gly Phe Asn Leu Ala Ala Ser Gln Ser Val Leu Gly Gly 
            420                 425                 430         


Phe Ala Ala Asp Thr Arg Gly Glu Ala Gly Glu Lys Gly Ile Ala Pro 
        435                 440                 445             


Gln Ser Arg Lys Ala Arg Lys Pro Gly Thr Ala Val Glu Thr Ala Gly 
    450                 455                 460                 


Ala Pro Glu Ala Val Arg Arg Gly Arg Ala Ala Cys Asn Gly Glu Ala 
465                 470                 475                 480 


Glu Thr Thr Gly Leu Glu Thr Ala Pro Gln Gln Val Ser Thr Ser Glu 
                485                 490                 495     


Glu Thr Ala Lys Ser Gly Arg Glu Leu Ala Cys Ala Arg Ala Gly Met 
            500                 505                 510         


Asp Glu Glu Glu Asp Ala Ala Phe Pro Ser His Val Val Ser Glu Phe 
        515                 520                 525             


Arg Gly Pro Pro Glu Ile Ser Asn Val Phe Asn Asp Leu Asp Cys Ser 
    530                 535                 540                 


Ser Ala Val Glu Arg Pro Gln Gly Cys Leu Gln His Ala Ala Val Gln 
545                 550                 555                 560 


Pro Phe Leu Pro Ala Val Ala Pro Glu Val Arg Pro Ser Ala Thr Thr 
                565                 570                 575     


Ala Gly Arg Thr Pro Met Gly Leu Trp Ser Glu Ala Gly Arg Val Ser 
            580                 585                 590         


Ser Leu Glu Thr Asp Thr Ala Glu Ile Gly Arg Arg Leu Asp Gly Glu 
        595                 600                 605             


Ser Ser Gly Ser Pro Asp Arg Trp Gly Asp Ala Arg Leu Ser Ser Pro 
    610                 615                 620                 


Asp Ser Val Pro Ser Ser Ala Asp Val Pro Val Pro Ser Arg Pro Gln 
625                 630                 635                 640 


Cys Gln Glu Gln Val Pro Gln Val Asp Pro Asp Ser Ser His Pro Leu 
                645                 650                 655     


Phe Ala Ser Cys Ser Ala Gly Ser Ser Ser Thr Ala Gly Ser Ala Ser 
            660                 665                 670         


Ala Leu Ala Gly Leu Ala Ser Pro Phe Pro Pro Pro Lys Ser Pro Lys 
        675                 680                 685             


Thr Gly Ala Asn Asp Pro Arg Met Thr Pro Ser Glu Gly Glu Met Arg 
    690                 695                 700                 


Ala Val Ser Gly Ala Pro Pro Ser Leu His Met Ser Pro Pro Ile Pro 
705                 710                 715                 720 


Pro Leu Ala Leu Gln Asp Ser Phe Gly Glu Cys Thr Ala Ser Ser Leu 
                725                 730                 735     


Ala Gly Val Asp Ala Pro Glu Ala Thr Ala Gly Gly Leu Ala Glu Gly 
            740                 745                 750         


Val Ala Thr Gly Gly Gly Ser Asp Ser Val Gly Glu Gly Arg Leu Pro 
        755                 760                 765             


Gly Ala Ala Ser Leu Glu Val Pro Ser Ser Pro Ser Ala Leu Leu Ser 
    770                 775                 780                 


Gly Ala Pro Ala Ser Leu Leu Leu Leu Leu Arg Asn Gly Gln Ser Gly 
785                 790                 795                 800 


Ala Ala Ala Leu Val Ala Ala Met Gln Gln His Gln Ala Leu Ser Gly 
                805                 810                 815     


Asp Ala Glu Glu Ala Leu Glu Ala Val Leu Ala Gly Gly Ser Asn Val 
            820                 825                 830         


Gly Asp Met Ala Asn Ser Ser Arg Gly Leu Glu Thr Val Gly Asp Gly 
        835                 840                 845             


Thr Arg Gly Ser Ala His Thr Thr His Ala Ala His Ser Ser Gly Arg 
    850                 855                 860                 


Asn Ala Val Gly Ala Cys Pro Ala Pro Asp Arg Glu Gly Glu Thr Val 
865                 870                 875                 880 


Ala Val Pro Thr Ser Val Leu Thr Asn Asn Pro Ala Ser Thr Ser Lys 
                885                 890                 895     


Thr Met Pro Ser Val Tyr Ser Thr Pro Ala Ser Ala Gly Leu Ser Leu 
            900                 905                 910         


Thr Ser Ser Ser Thr Pro Pro Val Leu Pro Thr Pro Asn Pro Gly Ala 
        915                 920                 925             


Gly Met Pro Pro Leu Ala Ser Ala His Ala Ala Ser Pro Ala Val Pro 
    930                 935                 940                 


Gly Asp Ala Asn Leu Gln Ser Leu Phe Phe Trp Ala Pro Gln Ala Cys 
945                 950                 955                 960 


Pro Leu Gln Pro Gly Ala Leu Ala Val Asp Ala Ser Ala Ser Ser Cys 
                965                 970                 975     


Gly Gly Val Gly Ser Cys Asn Gly Gly Pro Ala Pro Pro Gly Pro Ser 
            980                 985                 990         


Pro Val Ala Glu Leu Leu Asp Ala  Ser Gly Ser Gly Pro  Phe Gly Ala 
        995                 1000                 1005             


Ala Gly  Ser Gly Ala Gln Leu  Ala Ala Gly Pro Phe  Gly Ala Ala 
    1010                 1015                 1020             


Thr Pro  Ala Ser Ala Thr Phe  Gln Gln Gln Leu Leu  Leu Leu Ser 
    1025                 1030                 1035             


Ala Ala  Phe Asp Gln Ile Gly  Ser Ser Ser Phe Pro  Val Val Gly 
    1040                 1045                 1050             


Gly Glu  Asn Phe Ile Gly Tyr  Ser Ala Leu Ser Ala  Ala Arg Pro 
    1055                 1060                 1065             


Asp Ala  Ser Asp Leu Ser Ala  Ser Gly Gly Pro Pro  Ala Ser Leu 
    1070                 1075                 1080             


Pro Val  Leu Leu Ala Ala Ala  Asn Ala Gly Val Gly  Pro Gly Ala 
    1085                 1090                 1095             


Ala Gly  Val Gly Asp Gln Pro  Asp Phe Leu Ala Leu  Leu Gly Gly 
    1100                 1105                 1110             


Gly Ser  Ala Ser Arg Glu Gly  Ala Arg Asp Pro Val  Gly Gly Glu 
    1115                 1120                 1125             


Leu Gly  Gly Ala Gly Asn Ser  Ala Thr Ser Met Lys  Gly Val Lys 
    1130                 1135                 1140             


Arg Gln  Phe Val Gln Asn Gly  His Gly Thr Ala Ser  Gln Thr His 
    1145                 1150                 1155             


Pro Glu  Glu Asn Thr Gln Gly  Pro Gly Arg Ser Ala  Ala Val Val 
    1160                 1165                 1170             


Gly Arg  Ala Thr Lys Lys Gln  Arg Arg Gly Pro Pro  His Ser Gly 
    1175                 1180                 1185             


Ala Ala  Val Ser Ser Gly Ala  Pro Ser Gly Val Leu  Ala Val Pro 
    1190                 1195                 1200             


Gly Cys  Leu Gly Pro Pro Ser  Val Ala Lys Gly Pro  Gly Ser Asp 
    1205                 1210                 1215             


Glu Phe  Asn Leu Gln Gln Leu  Gln Gln Ser Arg Asp  Ser Arg His 
    1220                 1225                 1230             


Ser Ala  Asp Asn Ala Ser Gly  Ile Pro Asn Trp Pro  Pro Val Phe 
    1235                 1240                 1245             


Ser Asn  Gly Asn His Thr Leu  Gly Val Gly Thr Arg  Ser Pro Ser 
    1250                 1255                 1260             


Pro Ser  Val Cys Ser Ile Ser  His Asp Ala Gly Phe  Phe Gly Ala 
    1265                 1270                 1275             


Ser Gly  Ser Asn His Ala Gly  Ser Leu Ser Thr Pro  Val Cys Leu 
    1280                 1285                 1290             


Pro Gln  Leu Pro Gly Ala Ala  Ser Ala Ser Glu Gly  Pro Cys Glu 
    1295                 1300                 1305             


Ala Gln  Gln Thr Pro Pro Gly  Ser Ile Pro Glu Ala  Thr Thr Leu 
    1310                 1315                 1320             


Gly Gly  Leu Ser Ala Ala Ser  Gly Asn Pro Asn Ser  Thr Phe Ser 
    1325                 1330                 1335             


Val Ser  Ala Gly Gly Gly Val  Ala Pro Ala Ile Leu  Asn Leu Ser 
    1340                 1345                 1350             


Ser Ala  Ser Arg Thr Ser Ser  Gln Thr Ser Pro Cys  Cys Pro Thr 
    1355                 1360                 1365             


Ala Pro  Gly Ser Leu Leu Ser  Gly Gly Ser Gly Pro  Ala Leu Phe 
    1370                 1375                 1380             


Phe Ala  Gly Pro Pro Ser Pro  Leu Gln Lys Ala Pro  Val Tyr Ala 
    1385                 1390                 1395             


Gly Gly  Ser Gly Ser Val Cys  Ala Ser Ser Gly Asp  Ala Ile Ala 
    1400                 1405                 1410             


Ala Ala  Ala Leu Leu His Leu  Arg Thr Leu Gln Gln  Leu Gln Glu 
    1415                 1420                 1425             


Leu Gln  Arg His Phe Gln Arg  Pro Gly Ser Leu Pro  Pro Ala Val 
    1430                 1435                 1440             


Thr Pro  Ala Cys Leu Pro Ser  Gly Val Ala Gly Cys  Ser Pro Ala 
    1445                 1450                 1455             


Gly Leu  Gly Ala Ser Thr Pro  Gly Thr His Ser Val  Val Cys Asn 
    1460                 1465                 1470             


Ser Ser  Ala Ser Pro Val Pro  Gly Ala Ser Arg Val  Pro Arg Arg 
    1475                 1480                 1485             


Pro Asp  Gly Arg Gly Thr Gly  Gly Ala Gly Gly Asp  Pro Gly Pro 
    1490                 1495                 1500             


Ser Lys  Arg Gly Ser Val Ser  Val Ser Pro Ser Ala  Gln Gln Phe 
    1505                 1510                 1515             


Val Leu  Leu Gln Leu Lys Gln  Gln Gln Pro Gly Ser  His Gly Asn 
    1520                 1525                 1530             


Ala Leu  Ser Leu Gly Thr Gln  Gly Asn Ser Ser Asn  Pro Ala Pro 
    1535                 1540                 1545             


Ala Gly  Gly Ala Gly Ala Pro  Gln Gln His His Pro  Gly Val Cys 
    1550                 1555                 1560             


Tyr Ser  Pro Pro Lys Asp Val  Trp Arg Ala Arg Ile  Thr Val Asp 
    1565                 1570                 1575             


Gly Arg  Gln His Glu Gln Gln  Phe Ser Val Lys Arg  His Gly Phe 
    1580                 1585                 1590             


Glu Glu  Ala Arg Leu Leu Ala  Val Gln Trp Arg Ala  His Met Glu 
    1595                 1600                 1605             


Asn Leu  Arg Leu Gly Gly Ala  Ala Lys Gly Lys Gly  Asn Ala Ser 
    1610                 1615                 1620             


Ala Ser  Ser Ala Ser Ala Ala  Thr Ala Thr Ser Gln  Gly Ser Ser 
    1625                 1630                 1635             


Gln Ser  Ser His Gln Pro Pro  Leu Gly Ser Leu Met  Val Ser Gly 
    1640                 1645                 1650             


Asn Ser  Gly Met Ser Gly Pro  Gly Ala Gly Pro Leu  Ala Asn Arg 
    1655                 1660                 1665             


Gly Leu  
    1670 


<210>  13
<211>  2330
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Asp Tyr Ala Pro Ser Arg Phe Ala Ser Pro Pro Gly Asn Ala 
1               5                   10                  15      


His Pro Lys Ser Pro Leu Phe Ala Arg Pro His Ser Cys Arg Glu Met 
            20                  25                  30          


Glu Thr Arg Ala Ser Val Gly Thr Ser Arg Gly Ser Arg Gln Pro Leu 
        35                  40                  45              


Cys Leu Arg Gly Ser Pro His Gly Cys Leu Ser Pro Gln Lys Gly Gln 
    50                  55                  60                  


Asp Arg Leu Pro Ser Phe Ser Pro Leu Arg Thr Gln Pro Thr Leu Leu 
65                  70                  75                  80  


Ser Pro Pro Phe Pro Ser Lys Gly Cys Phe Ser Ser Cys Leu Pro Ser 
                85                  90                  95      


Ser Gln Ala Phe Thr Ser His Arg Ala Arg Gly Pro Ser Pro Glu Val 
            100                 105                 110         


His Ala Val Ser Ala Asp Ala Ser Thr Ser Ser Ser Pro Ile Ser Pro 
        115                 120                 125             


Ala Ser Arg Ser Ala Ser Glu Gln Gln Pro Arg Arg Glu Met Cys Ser 
    130                 135                 140                 


Pro Pro Gly Ala Ser Ser Asp Ser Thr Ser Pro Thr Gly Ser Ser Ser 
145                 150                 155                 160 


Cys Ser Ala Glu Gln Asp Asp Val Leu Cys Phe Arg Gln Arg Phe His 
                165                 170                 175     


Leu Pro Pro Leu Leu His Leu Ser Thr Ser Arg Lys Arg Leu Arg Glu 
            180                 185                 190         


Glu Asp Ala Ser Ala Ser Ala Cys Ile Ser Ser Leu Gly Asn Leu Pro 
        195                 200                 205             


Leu Asp Val Asp Thr Lys Arg Arg Arg Gln Glu Tyr Asp Arg Leu Ser 
    210                 215                 220                 


Thr Ala Ser Leu Ser Ser Phe Arg Ser Pro Lys Thr Pro Arg Leu Pro 
225                 230                 235                 240 


Ser Cys Leu Ala Arg Arg Asp Pro Glu Glu Ser His Ala Asp Leu Ser 
                245                 250                 255     


Glu Ser Arg Thr Phe Leu Gln Arg Leu Glu Ala Ala Gly Gln Ser Arg 
            260                 265                 270         


Lys Gly Asp Thr Ser Arg Glu Thr Ile Glu Ala Asp Glu Lys Lys Val 
        275                 280                 285             


Leu Ser Thr His Ser Thr Asp Thr Ser Val Gln Arg Ser Pro Ser Glu 
    290                 295                 300                 


Ser Ala Glu Arg Arg Ser Phe Gly Lys Arg Ser Asp Pro Asn Asn Gly 
305                 310                 315                 320 


Leu Pro Met Ala His Ser Pro Thr Pro Phe Thr Ser Lys Arg Thr Asp 
                325                 330                 335     


Leu Gly His Ala Leu Asp Asn Ala Leu Ser Met Arg Ala Ala Ser Arg 
            340                 345                 350         


Cys Gly Phe Pro Gly Pro Ala Glu Ala Thr Val Ala Pro Ala Ala Ser 
        355                 360                 365             


Gly Ala Ser Arg Thr Ala Ser Pro Leu Pro Phe Thr Val Pro Val Val 
    370                 375                 380                 


Leu Ala Ala Ser Pro Pro Thr Met Pro Ser Ala Cys Ser Pro Asp Leu 
385                 390                 395                 400 


Cys Arg Ala Ser Thr Ser Pro Leu Ser Cys Ala Gly Val Ser Ser Leu 
                405                 410                 415     


Asp Ala Pro Gln Ala Val Gly Arg Arg Ser Glu Val Ala Ala Cys Val 
            420                 425                 430         


Ser Pro Ala Ala Ser Glu Glu Thr Val Gly Asp Thr Arg Glu His Ala 
        435                 440                 445             


Asp Leu Ser Ser Pro Val Ala Trp Pro Val Ala Cys Leu Ala Ser Ser 
    450                 455                 460                 


Pro Gly Val Ala Lys Lys Pro Leu Asp Leu Gln Ile Asp Pro Glu Gln 
465                 470                 475                 480 


Pro Arg Gly Asn Asp Lys Leu Val Glu Pro Glu Phe Pro Gly Gly Thr 
                485                 490                 495     


Ala Ala Val Ser Glu Ser Ala Pro Val Ala Gly Ala Asp Ala Pro Arg 
            500                 505                 510         


Leu Cys Asp Tyr Gly Leu Ser Glu Ala Gly Val Leu Pro Ala Ser Gly 
        515                 520                 525             


Pro Trp Leu Arg Lys Pro Asn Pro Met Leu Thr Pro Asp Thr Glu Trp 
    530                 535                 540                 


Ala Ala Pro Ser Ser Gln Glu Asp Arg Ala Cys Thr Gln Lys Glu Thr 
545                 550                 555                 560 


Ser Ala Ala Arg Leu Ala Pro Asn Leu Leu Tyr Arg Gln Ala Asp Ala 
                565                 570                 575     


Ala Ala Asp Asn Val Thr Lys Gly His Glu Asp Asp Ser Gln Phe Pro 
            580                 585                 590         


Leu Arg Ser Gly Ser Phe Thr Ser Ser Ala Val Ala Cys Pro Ser Pro 
        595                 600                 605             


Pro Asp Val Gln Ala Asp Ser Glu Ala Ala Cys Thr Trp Gly Thr Pro 
    610                 615                 620                 


Gly Asn Gly Asp Thr Cys Glu Ser Thr Gly Gly Trp Arg Gly Ala Thr 
625                 630                 635                 640 


Asn Val Glu Ala His Thr Cys Leu Thr Gly Glu Asp Gly Ser Arg Tyr 
                645                 650                 655     


Gly Leu Gln Gly Pro Leu Ser Gln Asp Ser Pro Phe Gln Pro Pro Leu 
            660                 665                 670         


Pro Ser Met Arg Pro Val His Phe Gly Gly Phe Glu Ala Trp Gly Gly 
        675                 680                 685             


Asn Ser Glu Ala Ser Gln Gly Asp Ala Gln Gly Leu Gln Phe Pro Arg 
    690                 695                 700                 


Val Glu Arg Phe Ser Ser Arg Arg Thr Glu His Gly Ser Glu Gly Gly 
705                 710                 715                 720 


Phe Cys Gly Gln Leu Ala Gly Glu Leu Leu Pro Thr Ser Thr Ser Gly 
                725                 730                 735     


Gln Pro His Ser Gln His Val Ala Asp Leu Glu Ser His Thr Gly Ala 
            740                 745                 750         


Val Phe Ala Ser Cys Asp Pro Ala Met His Ala His Ala Ser Leu Tyr 
        755                 760                 765             


Gly Tyr Pro Gly Ala Phe Tyr Asn Ser Phe Gly Thr Ala Ser Ser Ile 
    770                 775                 780                 


Phe Asp Leu Thr Gln Pro Pro Gln Ala Phe Leu Tyr Gly Gly Thr Tyr 
785                 790                 795                 800 


Gly Asn Asn Gly Pro Asp Asp Tyr Cys Val His Arg Thr Asn Ser Thr 
                805                 810                 815     


Ser Cys Gln Gly Phe Thr Ala Pro Asp Asn Ile Ser Thr Gly Thr Leu 
            820                 825                 830         


Asn Thr Ala Asp Ala Gln Gln Glu Trp Thr Thr Pro Ala Pro Val Ser 
        835                 840                 845             


Asp Ala Ala Val Gly His Trp Glu Thr Ser Asp Phe Gly Pro Gln His 
    850                 855                 860                 


Leu Asn Gly Arg Ala Ser Ser Ser Val Pro Asp His Gly Gly Gly Leu 
865                 870                 875                 880 


Pro Phe Gly Gly Asn Gly Asn Ser Trp Gly Thr Ser Gly Asn Gly Asp 
                885                 890                 895     


Ala Trp Gly Thr Pro Gly Asn Gly Asp Thr Cys Glu Ser Thr Gly Gly 
            900                 905                 910         


Trp Arg Gly Thr Thr Asn Val Glu Gly His Thr Cys Leu Thr Gly Glu 
        915                 920                 925             


Asp Gly Ser Arg Tyr Gly Leu Gln Ala Pro Leu Ser Gln Asp Ser Pro 
    930                 935                 940                 


Tyr Gln Pro Pro Leu Pro Pro Met Gln Pro Val His Phe Ala Asn Phe 
945                 950                 955                 960 


Tyr Ser Ala Cys Phe Pro Pro Leu Pro Pro Pro Pro Val Phe Pro Gly 
                965                 970                 975     


Ile Gly Cys Val Ser Ala Ser Tyr Pro Asp Ile Leu Leu Pro Gln Ala 
            980                 985                 990         


Arg Phe Leu Ser Gln Ser Cys Pro  Gly Pro Pro Ser Val  Leu Arg Cys 
        995                 1000                 1005             


Pro Pro  Pro Ala Ala Leu Leu  Arg Gly Ser Ser Pro  Leu Asp Cys 
    1010                 1015                 1020             


Trp Ser  Leu Pro Ala Leu Pro  Ser Leu Pro Arg Ile  Pro Ser Asp 
    1025                 1030                 1035             


Phe Ala  Ser Asp Pro Ala Ser  Val Pro Leu Pro Ala  Ala Val Gln 
    1040                 1045                 1050             


Asn Leu  Pro Glu Asp Ser Pro  Arg Leu Arg Leu Pro  Cys Gln Gly 
    1055                 1060                 1065             


Ala Ser  Thr Arg Asp Gln Ser  Pro Leu Gln Tyr Glu  Gly Asn Phe 
    1070                 1075                 1080             


Gly Gly  Ser Asp Glu Val Leu  Arg Pro Gln Val Glu  Val Ala Glu 
    1085                 1090                 1095             


Asn Arg  Gly Thr Pro Asn Phe  Leu Ala Ala Ser Tyr  Ser Leu Leu 
    1100                 1105                 1110             


Gly Ala  Phe Ser Cys Glu Gly  Asp Asn Arg Asp Asn  Glu Tyr Glu 
    1115                 1120                 1125             


Thr Gln  Leu Trp Gln Gln Leu  Asn Glu Ser Gly Glu  Leu Gly Val 
    1130                 1135                 1140             


Ser Gly  Leu Pro Gln Pro Tyr  Ser Val Glu Glu Gly  Arg Arg Gln 
    1145                 1150                 1155             


Glu Leu  Gln Ser Pro Tyr Pro  Ala Pro Tyr Glu Asn  Ile Pro Tyr 
    1160                 1165                 1170             


Ser Thr  Pro Ser Tyr Asn Ser  Val Ser Tyr Thr Ala  Ala Ser Lys 
    1175                 1180                 1185             


Asp Arg  Leu Val Gly Asp Asn  Thr Ala Tyr Asn Gly  Ala Ala Tyr 
    1190                 1195                 1200             


Cys Pro  Phe Tyr Gly Gly Ser  Gly Met Tyr Glu Thr  Pro Gln Arg 
    1205                 1210                 1215             


Ser Glu  Glu Asn Ser Leu Tyr  Ser Ala Asp Pro Gln  Val His Phe 
    1220                 1225                 1230             


Ser Glu  Ser Glu Lys Thr Gly  Ser Ser Asp Ser Phe  Pro Tyr Ser 
    1235                 1240                 1245             


Phe Phe  Ser Leu Gly Thr Pro  Ala Leu Tyr Pro Gly  Gly Ser Leu 
    1250                 1255                 1260             


Gln Thr  Gly Ala His Leu Glu  Glu Val Pro Gly Ser  Gly Asp Ala 
    1265                 1270                 1275             


Glu Gly  Ser Ala Trp Ser Pro  Ser Leu Glu Ser Arg  Arg Leu Arg 
    1280                 1285                 1290             


Gly Arg  Thr Arg Ser Pro His  Ala Gln Ser Pro Asn  Ser Asn Arg 
    1295                 1300                 1305             


Ser Arg  Gly Ala Ala Trp Thr  Phe Ser Pro Ala Ser  Leu Pro Phe 
    1310                 1315                 1320             


Glu Val  Pro Ala Ala Ala Lys  Ala Ser Gly Arg Lys  Arg Arg Ala 
    1325                 1330                 1335             


Pro Gly  Ser Leu Pro Ala Gln  Thr Asp Arg Gly His  Lys Asp Phe 
    1340                 1345                 1350             


Leu Leu  Glu Leu Leu Ala Ser  Arg Leu Glu Pro Val  Lys Gly Val 
    1355                 1360                 1365             


His Met  Asp Arg Leu Arg Lys  Thr Trp Val Ala Ser  Trp Leu Val 
    1370                 1375                 1380             


Gly Lys  Arg Arg Ile Thr Arg  Ile Phe Ser Phe Gln  Lys Phe Gly 
    1385                 1390                 1395             


Phe Phe  Gly Ala Arg Glu Gln  Ala Ile Arg His Arg  Arg Glu Ala 
    1400                 1405                 1410             


Leu Leu  Asn Pro Glu Leu Asp  Asn Ser Glu Arg Arg  Glu Ala Leu 
    1415                 1420                 1425             


Ala Asn  Val Glu Arg Ala Thr  Asp Asp Glu Leu Gln  Gln Ala Ala 
    1430                 1435                 1440             


Asp Ala  Leu Pro Phe Val Val  Gly Val Thr Tyr His  Arg Ala Ser 
    1445                 1450                 1455             


Arg Cys  Trp Val Ala Asn His  Arg Lys Pro Met Gly  Lys Ile Val 
    1460                 1465                 1470             


Gln Arg  Lys Lys Phe Ala Val  Ala Glu Leu Gly Phe  Leu Glu Ala 
    1475                 1480                 1485             


Arg Tyr  His Ala Ala Val Met  Met Phe Cys Trp Asn  Lys Gln Gly 
    1490                 1495                 1500             


Arg Thr  Gln Glu Pro Glu Asp  Tyr Asp Gln Gly Ala  Thr Glu Ala 
    1505                 1510                 1515             


Phe Asn  Ser Arg Gln Val Pro  Gln Arg Pro Gly Asp  Asp Arg Ala 
    1520                 1525                 1530             


Phe Glu  Phe Ser His Pro Thr  Cys Ser Glu Asn Glu  Pro Leu Tyr 
    1535                 1540                 1545             


Thr Leu  Lys Ala Leu Asp Ser  Gly Thr Cys Asp Asp  Ala Met Val 
    1550                 1555                 1560             


Leu Leu  Ala Phe Ile Cys Gly  Ser Pro Trp Arg Lys  Ile Cys Arg 
    1565                 1570                 1575             


Gly Gln  Gln Cys Gly Asp Asp  Pro Thr Leu Leu Glu  Ala Ala Ser 
    1580                 1585                 1590             


Thr Ile  Gln Thr Glu Lys Ser  Leu Trp Arg Thr Arg  Val Lys Ser 
    1595                 1600                 1605             


Ala Ala  Asp Glu Val Arg Glu  Gly Pro Gln Arg Arg  Leu Glu Gly 
    1610                 1615                 1620             


Thr Asp  Ala Gly Asp Ser Gly  Ala Phe Pro Arg Gly  Gln Ser Pro 
    1625                 1630                 1635             


Glu Lys  Gly Arg Pro Arg Arg  Arg Arg Lys Thr Ala  Thr Leu Arg 
    1640                 1645                 1650             


Glu Gln  Glu Asp Val Thr Glu  Asp Lys Thr Glu Asp  Gly Arg Glu 
    1655                 1660                 1665             


Asp Lys  Thr Glu Asp Gly Gly  Glu Asp Lys Thr Glu  Asp Gly Gly 
    1670                 1675                 1680             


Glu Asp  Gly Arg Glu Asp Glu  Gly Glu Asp Glu Gly  Glu Asp Pro 
    1685                 1690                 1695             


Gly His  Gly Trp Gly Glu Arg  Arg Arg Cys Arg Lys  Ser Asp Arg 
    1700                 1705                 1710             


Glu Asn  Ala Gly Glu Ala Glu  Arg Gly Gln Lys Arg  Glu Lys Arg 
    1715                 1720                 1725             


Gln Gln  Ser Glu Gly Arg Cys  Val Val Ala Glu Val  Asp Leu Arg 
    1730                 1735                 1740             


Asp Ala  Lys Asp Thr Val Val  Arg Arg Asn Arg Val  Ala Arg Arg 
    1745                 1750                 1755             


Glu Gly  Leu Glu Thr Gly Phe  Gly Lys Lys Asn Ala  Lys Ser Gly 
    1760                 1765                 1770             


Ala Glu  Ser Cys Leu Ser Gln  Thr Pro Ala Leu Gly  Pro Ser Ser 
    1775                 1780                 1785             


Pro Pro  Phe Pro Val Ser Phe  Lys Lys Arg Arg Lys  Ser Ser Ser 
    1790                 1795                 1800             


Arg Glu  Ala Asp Leu Arg Gln  Ser Arg Pro Arg Arg  His Arg Asn 
    1805                 1810                 1815             


Asp Thr  Glu Glu Ala Arg Ser  Ile Cys Glu Asp Ser  Pro Ser Ser 
    1820                 1825                 1830             


Glu Val  Ala Pro Thr Pro Ala  Ser Ser Ser Phe Ser  Pro Ala Ala 
    1835                 1840                 1845             


Ser Leu  Ser Ser Asp Gly Ser  Arg Leu Gly Ser His  Asn His Asp 
    1850                 1855                 1860             


Leu Thr  Asp Ser Gly Arg Ser  Ala Ser Val Ser Arg  Gly Arg Ser 
    1865                 1870                 1875             


Thr Asp  Phe Ser Met Phe Ala  Gly Leu Pro Tyr Leu  Lys Ser Leu 
    1880                 1885                 1890             


Glu Ser  Asn Thr Arg Phe Val  Pro Pro Ser Arg Pro  Gly Glu Ser 
    1895                 1900                 1905             


Gly Leu  Pro Asn Val Tyr Ala  Ser Tyr Asn Ser Gly  Leu Ala Phe 
    1910                 1915                 1920             


Glu Ala  Asn Arg Pro Cys Pro  Leu Ala Phe Asp Ser  Arg Ala Asp 
    1925                 1930                 1935             


Pro Thr  Gly Trp Pro His Thr  Phe Pro His Pro Ala  Glu Ala Tyr 
    1940                 1945                 1950             


Gly Ser  Gly Ile Ala Ser Trp  Thr Pro Asn Ala Asn  Gly Phe Phe 
    1955                 1960                 1965             


Glu Ser  Leu Ala Tyr Thr Gly  Asn Leu Glu Glu Leu  Arg Asp Leu 
    1970                 1975                 1980             


Cys Gly  Arg Thr Pro Asp Ala  Arg Asp Ser Ser Asp  His Trp Gln 
    1985                 1990                 1995             


Glu Ala  Ala Ala Ala Ala Ser  Ser Arg Leu Pro Leu  Arg Pro Pro 
    2000                 2005                 2010             


Ala Val  His Ser Trp Gln Asp  Ala Pro Cys Ala Lys  Asp Pro Ala 
    2015                 2020                 2025             


Pro Cys  Val Glu Leu Ala Arg  Asp Glu Cys Leu Ala  Gly Gly Asp 
    2030                 2035                 2040             


Arg Gln  Thr Cys Arg Phe His  Ser Ala Phe Asp Ser  Ala Asp Ala 
    2045                 2050                 2055             


Gly Asp  Tyr Lys Phe Asn Thr  Asp Ala Arg Cys Leu  Arg Gly Pro 
    2060                 2065                 2070             


Thr Phe  Asn Pro His Ser Asn  Ala Val Ala Thr Leu  Arg Arg Glu 
    2075                 2080                 2085             


Gln Glu  Ala Ala Arg Gly Ala  Ser Gly Gln Thr Pro  Ser Phe Phe 
    2090                 2095                 2100             


Phe Pro  Arg Leu Val Pro Val  Ala Gln Thr Asp Trp  Glu Ala Asp 
    2105                 2110                 2115             


Pro Gly  Arg Gly Ser Gly Asp  Ser Leu Ser Ala Pro  His Glu Ala 
    2120                 2125                 2130             


Gly Glu  Ala Val Gly Val Glu  Gly Ser Glu Gly Ala  Pro Cys Glu 
    2135                 2140                 2145             


Trp Asn  Phe Glu Arg Asp Ala  His Pro Val Ile Leu  Pro Thr Ser 
    2150                 2155                 2160             


Asn Cys  Ser His Gly His Glu  Arg Leu Ala Ser Ser  Asn Ala Phe 
    2165                 2170                 2175             


Thr Glu  Ala Lys Gln Arg Asn  Ala Leu Arg Cys Thr  Pro Gln Glu 
    2180                 2185                 2190             


Thr Val  Gly Gly Val Asn Glu  Asn Gly Ser Pro Leu  Phe Ser Thr 
    2195                 2200                 2205             


His Arg  Asp Ala Pro Glu Ala  Met Ser Ala Leu Thr  Glu Val Ser 
    2210                 2215                 2220             


Asp Arg  Glu Thr Gln Arg Gly  Pro Ala Val Leu Gln  Ser Gly Asn 
    2225                 2230                 2235             


Thr Glu  Ala Leu Leu Gln Asp  Ser Thr Ser Asn Ser  Ala Ser Pro 
    2240                 2245                 2250             


Thr Gln  Arg Arg Ala His Gly  Leu Asp Pro Glu Pro  Asp Glu Ser 
    2255                 2260                 2265             


Lys Ala  Arg Gly Glu Arg Ser  Lys Glu Glu Asp Arg  Glu Thr Leu 
    2270                 2275                 2280             


Arg Thr  Glu Ala Pro Ser Lys  Gly Arg Lys Gln Ile  Leu Ser Pro 
    2285                 2290                 2295             


Pro Thr  Glu Arg Asn Ser Met  Tyr Gly Glu Ala Met  Ser Ile Asp 
    2300                 2305                 2310             


Arg Gln  Val Ser Ala Leu Pro  Thr Leu Leu Ser His  Gly Thr Ala 
    2315                 2320                 2325             


Phe Pro  
    2330 


<210>  14
<211>  1438
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Ala Ser Pro Pro Ala Gln Pro Leu Gly Ala Thr Ser Pro 
1               5                   10                  15      


Cys Thr Phe Ser Pro Pro Cys Ser Phe Ser Pro Ser Asp Thr Cys Ser 
            20                  25                  30          


Val Phe Phe Ala Thr Pro Ser Arg Ala Val Ser Ala Val Pro Glu Leu 
        35                  40                  45              


Pro Ala Thr Ser Ser Ala Gln Leu Pro Glu Arg Thr Arg Leu Arg Asn 
    50                  55                  60                  


Arg Ser Ile Gln Ser Ala Ser Thr Thr Glu Ala Ser Pro Phe Val Asp 
65                  70                  75                  80  


Ser Ala Ser Leu Phe Pro Glu Ser Leu Ser Glu Ala Pro Lys Ala Val 
                85                  90                  95      


Ser Val Asp Gly Glu Ser Arg Arg Thr Arg Glu Arg Arg Arg Lys Ser 
            100                 105                 110         


Arg Ser Leu Leu Ala Ala Ala Glu Glu Thr Pro Glu Ala Thr Ala Ala 
        115                 120                 125             


Ser Pro Asn Gly Ser Ser Ser Glu Ile Ser Asp Glu Ala Ser Thr Phe 
    130                 135                 140                 


Val Leu Thr Pro Ala Thr Ala Ser Leu Ala Pro Ala Ala Leu Pro Pro 
145                 150                 155                 160 


Phe Met Thr Glu Arg Ser Asp Pro Thr Glu Lys Lys Tyr Glu Ala Gln 
                165                 170                 175     


Asn Met Gln Val Thr Ala Val Glu Pro Val Gly Leu Ala Pro Arg Ser 
            180                 185                 190         


Ala Ser Arg Ser Glu Leu Gly Asp Ala Glu Ser Leu Ser Ala Gly Lys 
        195                 200                 205             


Ser Gly Leu Gln Gly Glu Ser Ala Ala Pro Thr Ala Ala Leu Glu Ala 
    210                 215                 220                 


Asp Ala Gly Glu Thr Arg Leu Glu Thr Gly Leu Ala Gly Glu Pro Val 
225                 230                 235                 240 


Asn Ser Ser Ser Glu Gly Val Gly Tyr Gly Gly Asp Glu Gln Thr Val 
                245                 250                 255     


Ala Gly Glu Thr Arg Glu Pro Gly Thr Ala Glu Glu Lys Leu Gly Asp 
            260                 265                 270         


Leu Lys Pro Glu Val Arg Pro Arg Phe His Ala Tyr Ala Glu Gln Asp 
        275                 280                 285             


Val Cys Ala Trp Ala Thr Ser Met Leu Ala Arg Lys Glu Leu Arg Lys 
    290                 295                 300                 


Leu Lys Ala Ala Ala Val Lys Leu Glu Gly Asp Arg Met Pro Arg Ser 
305                 310                 315                 320 


Asp Val Val Gly Leu Tyr Phe Lys Lys His Arg Pro Cys Trp Ser Val 
                325                 330                 335     


Asp Tyr His Thr Arg Gln Gly Lys Arg Lys Thr Val Glu Phe Phe Val 
            340                 345                 350         


Pro Asp Leu Ser Arg Glu Thr Ile Glu Leu Val Leu Val His Ala Ile 
        355                 360                 365             


Glu Cys Arg Lys Tyr Met Pro Arg Arg Phe Asp Gln Ala Pro Ala Phe 
    370                 375                 380                 


Val Pro Glu Pro Asp Asp Thr Thr Ser Gly Met Pro Tyr Arg Tyr Gly 
385                 390                 395                 400 


Ala Arg Leu Leu Ser Pro Lys Val Leu Ala Trp Ile Val Glu Asn Thr 
                405                 410                 415     


Asn Gly Ser Gly Arg Thr Ser Gln His Gly His Gly Gln Ser Arg Arg 
            420                 425                 430         


Leu Glu Gly Asp Lys Val Gly Glu Gly Asp Ala Gly Ala Gln Leu Leu 
        435                 440                 445             


Ser Gly Pro Ala Gly Ile Asp Ala Phe Gly Ser Arg Ser Pro Arg Ala 
    450                 455                 460                 


Gly Phe Ala Arg Gln Arg Asp Asn Asn Ser Arg Arg Gln Gly Lys Ala 
465                 470                 475                 480 


Ser Gly Cys Arg Pro Gly Ala Asp Leu Ala Thr Ser Ser Glu Glu Lys 
                485                 490                 495     


Ala Thr Arg Glu Gly Glu Thr Glu Leu Pro Gly Gly Ser Ala Gly Pro 
            500                 505                 510         


Gly Ser Val Pro Ala Gly Thr Ala Tyr Gly Asp Tyr Ala Arg Gln Leu 
        515                 520                 525             


Pro Ser Glu Gly Tyr Gln Thr Pro Pro Thr Met Glu Gly Arg Met Thr 
    530                 535                 540                 


Pro Ala Gly Leu Leu Ser Gly Gln Glu Phe Gly His Gly Gln Gly Met 
545                 550                 555                 560 


Gln Gly Ala Gly Val Met Trp Arg Asp Asp Pro Arg Gln Ala Leu Gln 
                565                 570                 575     


Ala Met Pro Gln Pro Leu Asn Leu Ala Pro His Ala Thr Pro Phe Met 
            580                 585                 590         


Ser Arg Ala Gly Gly Leu Tyr Asp Gln Arg Glu Ala Ser Val Glu Pro 
        595                 600                 605             


Gly Arg Asp Val Tyr Pro Val His Tyr Pro Thr Pro Tyr Ala Tyr Gly 
    610                 615                 620                 


Pro Gly Ile Pro Ala Asp Ala Gly Ala Pro Ser Ala Gly Pro Gly Pro 
625                 630                 635                 640 


Tyr Pro His Gln Phe Pro Ser Gly Gly Ala Gly Tyr Val Val Asn Gly 
                645                 650                 655     


Arg Val Pro Asp Ser Ala Asp His Glu Ala His Ser Pro Arg Ser Pro 
            660                 665                 670         


Glu Ser Tyr Trp Gly Pro Gln Ala Gly Ser Gln Gly Ala Glu Asp Lys 
        675                 680                 685             


Asp Cys Gln Val Val Gly Cys Met Leu Pro Asn Gly Ser Glu Met Ala 
    690                 695                 700                 


Met Arg Arg Met Glu Ser Tyr Val Gly Asp Arg Asp Asn Leu Arg Gly 
705                 710                 715                 720 


Ser Ala Ala Phe Ala Gly Asp Gly Arg Thr Gln Ala Glu Gly Leu Ser 
                725                 730                 735     


Pro Gln Cys Glu Pro Asn Ala Lys Arg Arg Arg Leu Gln Ala Gly Gly 
            740                 745                 750         


Asp Gly Ser Asn Gly Gly Leu Glu Ala Ser Gly Pro Glu Arg Pro Phe 
        755                 760                 765             


Pro Gly Ser Gln Met Leu Gln Pro Ser Asp Glu Trp Ala Arg Asn Gly 
    770                 775                 780                 


Gln Arg Ala Phe Ala Val Gln Pro Gly Thr Gly Gly Arg Thr Phe Met 
785                 790                 795                 800 


Asn Gly Gly Phe Arg Gln Pro Gly Pro Glu Asp Ala Arg Gln Pro Leu 
                805                 810                 815     


Leu Leu Ser Ser Ala Pro Tyr Ser Pro Pro Ser Val Phe Pro Ala Ala 
            820                 825                 830         


Pro Pro His Leu Ser His Ala Val Arg Leu Pro Pro Gly Ser Ser Asp 
        835                 840                 845             


Ala Ala His Arg Thr Pro Met Ser Gly Ala Ala Gly Cys Ala Ser Pro 
    850                 855                 860                 


Val Ala Ser Ala Phe Arg Lys Glu Ala Glu Ala Ser Glu Trp Pro Ser 
865                 870                 875                 880 


Asn Glu Val Tyr Gly Ser Pro Gln Ala Phe Pro Asp Lys Ala Asn Ala 
                885                 890                 895     


Phe Ala Lys Gly Val Thr Leu Pro Arg Arg Gln Ser Phe Ala Phe Ser 
            900                 905                 910         


Asp Ala Gly Leu Pro Thr Pro Thr Thr Ser Pro His His Gly Ser Tyr 
        915                 920                 925             


Cys Ala Ser Thr Ile Ala Ser Ser Ser Pro Lys Ser Ala Ser Pro Val 
    930                 935                 940                 


Ser Gln Ser Gly Cys Phe Pro Cys Asp Phe Tyr Pro Ala Thr Ala His 
945                 950                 955                 960 


Tyr Ser Gly Pro Gly Val Glu Thr Pro Ser Asp Val Ser Ser Phe Val 
                965                 970                 975     


Pro Ala Pro Ala Glu Thr Ala Glu Gln Gln Ile His Gly Ala Gly Gln 
            980                 985                 990         


Ala Ala Val Lys Thr Pro Glu Ser  Gly Leu His Met Pro  Ser Ser Gly 
        995                 1000                 1005             


Trp Pro  Gln Gln Ala Ser Val  Pro Gly Ala His Gly  Ala Glu Phe 
    1010                 1015                 1020             


Tyr Ala  Ser Arg Ala Phe Ala  Asn Gly Ala His Ala  Pro Ser Leu 
    1025                 1030                 1035             


Ser Leu  Arg Pro Ser Trp Arg  Tyr Pro Gly Gly Glu  Arg Ser Glu 
    1040                 1045                 1050             


Gly Asp  Leu Thr Thr Gln Glu  Gln Asn Ala Pro Ala  Gly Ala Ser 
    1055                 1060                 1065             


Pro Ser  Ser Pro Val Trp Ser  Gly Asn Thr Gly Val  Cys Thr Thr 
    1070                 1075                 1080             


Glu Gly  Cys Gly Val Trp Leu  Glu Asn Arg Gln Ala  Ala Gly Ser 
    1085                 1090                 1095             


Val Glu  Gly Ala Ala Asp Pro  Gly Val Gln Gly Ser  Ala Cys Met 
    1100                 1105                 1110             


Gln Gly  Lys Pro Gln Glu Gly  Gly Arg Cys Ser Pro  Glu Pro Ala 
    1115                 1120                 1125             


Leu Gly  Val Arg Arg Pro Ala  Glu Phe Ala Gly Ala  Pro Val Gly 
    1130                 1135                 1140             


Ala Cys  Arg Ala Val Glu Asp  Arg Thr Met Thr Gly  Glu Arg Gly 
    1145                 1150                 1155             


Ala Trp  Gly Asn Glu Ala Arg  Arg Glu Thr Val Thr  Gly Asp Gln 
    1160                 1165                 1170             


Glu Cys  Cys Gly Asp Gln Ala  Arg Asp Pro Met Val  Phe Ser His 
    1175                 1180                 1185             


Met Gly  Ser Arg Ala Glu Leu  Ser Gly Phe Asp Asp  Gly Ser Glu 
    1190                 1195                 1200             


Leu Pro  Pro Ala Ser Pro Leu  Asn Glu Cys Met His  Pro Leu Gly 
    1205                 1210                 1215             


Lys Pro  Gly Ser Arg Ile Phe  Pro Glu Phe Gly Ala  Trp Pro Gly 
    1220                 1225                 1230             


Ser Pro  Pro His Glu Gly Ser  Phe Val Gln Glu Phe  Asp Ile Phe 
    1235                 1240                 1245             


Lys Glu  Asn Gly Glu Gly Ala  Ala Gly Ala Val Asp  Asp Ala Met 
    1250                 1255                 1260             


Ala Leu  Trp Pro Asn Gly Gly  Ala Phe Gly Gln Arg  Thr Asp Pro 
    1265                 1270                 1275             


Leu Ala  His Glu Glu Glu Lys  Glu Gly Glu Leu Trp  Lys Gly Gln 
    1280                 1285                 1290             


Pro Thr  Pro Phe Cys Ser Ser  Pro Ala Leu Trp Cys  Val Cys Pro 
    1295                 1300                 1305             


Val Glu  His Thr Arg Glu Phe  Asp Val Met Asp Met  Val Thr Leu 
    1310                 1315                 1320             


Pro Asp  Leu Ser His Thr Ala  Gly Pro Val Ser Arg  Pro Leu Pro 
    1325                 1330                 1335             


Asn Ala  Pro Leu Cys Gly Gly  Cys Val Val Ala Gly  Val Gly Glu 
    1340                 1345                 1350             


Ala Gln  Ala Gly Asp Gly Glu  Ser Lys Gln Gly Ala  Lys Leu Ala 
    1355                 1360                 1365             


Pro Asp  Ser Gln His Leu His  Gly Gly Ala Ala Asn  Pro Gly Ala 
    1370                 1375                 1380             


Val Gly  Lys Leu Val Thr Asp  Glu Thr Ala Gln Thr  Ser Gly Arg 
    1385                 1390                 1395             


Glu Gln  His Pro Gly Glu Gly  Asp Ser Thr Glu Gln  Arg Leu Ser 
    1400                 1405                 1410             


Gly Leu  Ala Ala Arg Ala Thr  Pro Gln Arg Glu Thr  Lys Arg Pro 
    1415                 1420                 1425             


Gly Pro  Ser Arg Arg Thr Glu  Gly Glu Leu 
    1430                 1435             


<210>  15
<211>  3817
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Phe Glu Arg Gly Glu Ser Pro Gly Asp Ser Arg Gly Ser Val 
1               5                   10                  15      


Ala Phe Leu His His Thr Glu Lys Leu Glu Arg Leu Pro Gly Thr Gly 
            20                  25                  30          


Glu Thr Thr Ile Arg Gly Met Ser Phe Thr Pro Pro Tyr Ile Cys Met 
        35                  40                  45              


Glu Arg Pro Pro Arg Ala Asn Cys Glu Ala Leu Arg Leu Lys Ser Pro 
    50                  55                  60                  


Pro Glu Asn Arg Ala Phe Ser Ser Arg Ser Glu Ser Pro Ser Pro Thr 
65                  70                  75                  80  


Pro Phe Ala Arg Glu Cys Ala Ser Leu Gly Leu Val Trp Gly Asp Glu 
                85                  90                  95      


Gly Thr Arg Ala Gly Leu Leu Arg Thr Arg Leu Phe Thr Pro Pro Asp 
            100                 105                 110         


His Thr Pro His Leu Leu Ala Glu Thr Gly Ala Ser Cys Leu Glu Asp 
        115                 120                 125             


Leu Phe Pro Gly Thr Val Pro Gln Leu Leu Ser His Leu Pro Ser Pro 
    130                 135                 140                 


Pro Pro Val Pro Gly Val Ala Arg Ala Ser Arg Ser Ser Ser Pro Leu 
145                 150                 155                 160 


Ala Gly Gly Ser Ser Leu Ala Cys Ala Ser Pro Trp Pro Arg Ser Ala 
                165                 170                 175     


Thr Pro Phe Phe Ala Ala Asn Met Pro Ala Leu Leu Pro Gly Arg Gly 
            180                 185                 190         


Pro Met Arg Val Thr Lys Trp Leu Asp Gly Gln Val Ser Asp Pro Gln 
        195                 200                 205             


Ser Asp Ser Cys Leu Arg Gly Gly Ala Ser Arg Val Glu Arg Ala Ala 
    210                 215                 220                 


Ala Leu Leu Cys Gly Arg Ser Glu Glu Glu Gln Glu Arg Glu Arg Ser 
225                 230                 235                 240 


Val Asp Glu Arg Arg Leu Arg Lys Ala Ile Gly Val Thr Asp Glu Asp 
                245                 250                 255     


Glu Ser Glu Arg Glu Arg Glu Thr Glu Gly Gly Val His Glu Arg Leu 
            260                 265                 270         


Ser Arg Cys Ala Ala Ala Thr Ala Ala Asp Arg Ala Asn Asn Leu Leu 
        275                 280                 285             


Gly Leu Gly Val Glu Arg Gly Pro Glu Val Ala Gly Gly Arg Leu Gly 
    290                 295                 300                 


Gly Tyr Trp Thr Thr Glu Ser Glu Val Tyr Pro Gln Arg Ile Gly Glu 
305                 310                 315                 320 


Leu Glu Gly Glu Gly Leu Gly Ser Pro Asp Pro Val Ala Ala Ser Ala 
                325                 330                 335     


Leu Val Thr Ala Val Gln Asp Ser Arg Glu Asn Leu Asn Cys Leu Thr 
            340                 345                 350         


Gly Val Leu Thr Thr Leu Arg Leu Ser Ser Arg Asp Ser Glu Gly Asp 
        355                 360                 365             


Phe Asp Leu Pro Leu Phe Val Gln Ser Arg Lys Trp Arg Ala Lys Tyr 
    370                 375                 380                 


Asn Arg Arg Ser Leu Asp Leu Lys Gly Thr Val Ala Arg Ser Lys Ala 
385                 390                 395                 400 


Leu Gly Tyr Pro Ala Gly Leu Gln Ile Pro Glu Thr Tyr Arg Asp Leu 
                405                 410                 415     


Lys Asn Cys Met Gln Arg Pro Pro Ser Ile Asp Ala Ala Asp Ser Arg 
            420                 425                 430         


Ala Trp Arg Ser Ala Glu Ala Pro Arg Ala Ala Lys Lys Val Phe Ser 
        435                 440                 445             


Glu Gly Arg Arg Ala Thr Asp Arg Asp Glu Gln Val Ala Phe Val Glu 
    450                 455                 460                 


Asp Glu Val Thr Glu Gln Leu Leu Phe Asn Ala Asn Ala Ala Val Glu 
465                 470                 475                 480 


Gly Thr Thr Leu Tyr Asn Asn Leu Leu Cys Lys Tyr Gly Leu Glu Thr 
                485                 490                 495     


Arg Cys Phe Ser Thr Ser Ser Ala Pro Gly Asn Thr Ala Phe Glu Ser 
            500                 505                 510         


Arg Leu Ala Arg Ser Asp Ala Asp Pro Thr Ala Ser Ser Gln Ser Ala 
        515                 520                 525             


Ser Ala Leu Ser His Ala Ala Val Ser Pro Ser Leu Ala Ser Ala Leu 
    530                 535                 540                 


Pro Val Ser Ser Leu Leu Leu Glu Asp Ala Ala Asp Ala Val Gly Asp 
545                 550                 555                 560 


Arg Ser Glu Leu Glu Thr Gly Ser Gln Ala Glu Ala Ala Ile Pro Thr 
                565                 570                 575     


Ser Glu Ala Ser Cys Met Arg Arg Glu Lys His Val Gly Glu Glu Ser 
            580                 585                 590         


Arg Ala Asp Lys Gly Ala Phe Leu Arg Ser Ala Ser Asp Ser Thr His 
        595                 600                 605             


Ala Glu Glu Asp Gly Leu Ser Gly Gly Lys Asp Ala Ser Ser Arg Glu 
    610                 615                 620                 


Gly Gly Ser Glu Glu Arg Glu Glu Ala Ala His Glu Ala Ala Asp Ser 
625                 630                 635                 640 


Leu Trp Ser Leu Val Leu Asn Arg Asn Ile Ala Ala Leu Pro Gly Phe 
                645                 650                 655     


Met Thr Val Gly Arg Tyr Glu Cys Asp Leu Leu Pro Lys Arg Ser Ala 
            660                 665                 670         


Phe Ser Arg Lys Gln Leu Ala Gly Leu Val Ala Gly Ser Arg Pro Leu 
        675                 680                 685             


Pro Val Leu Pro Ser Ser Ser Asp Thr Pro Gly Ser Ala Ser Thr Glu 
    690                 695                 700                 


Leu Leu Ala Glu Arg Val Ala Cys Ala Leu Thr Leu Asp Glu Gly Glu 
705                 710                 715                 720 


Ala Trp Asn Pro Ser Asp Ala Ser Asp Leu Asp Asp Phe Leu Glu Ser 
                725                 730                 735     


Ser Cys Ala Pro Asn Ala Leu Arg Arg Gly Arg Gln Ala Val Val Pro 
            740                 745                 750         


Val Arg Gly Ala Arg Arg Arg Arg Gly Ala Asp Leu Gly Leu Ser Pro 
        755                 760                 765             


Pro Pro Ser Ser Pro Ala Val Arg Cys Arg Ser Leu Val Arg Trp Ser 
    770                 775                 780                 


Gln Gln Arg Pro Phe Phe Ser Asn Val Ser Ala Cys Ala Gly Ala Ala 
785                 790                 795                 800 


Asp Ser Arg Arg Glu Glu Trp Lys Asp Ala Gly Lys Val Ala Lys Pro 
                805                 810                 815     


Gly Ser Glu Ser Ala Leu Thr Ser Arg Asp Leu His Ala Ser Thr Gly 
            820                 825                 830         


Leu Val Asn Ala Ala Leu Asp Ser Ser Glu Gln Lys Ser Gly Glu Arg 
        835                 840                 845             


Glu Ser Ser Leu Ser Pro Gln Glu Arg Ile Leu Thr Gln Val Lys Lys 
    850                 855                 860                 


Glu Leu Glu Asp Glu Arg Val Arg Glu Lys Gln Thr Ile Arg Asp Lys 
865                 870                 875                 880 


Asp Ser Glu Lys Gly Gln Gly Gly Glu Ser Asn His His Met Pro Gly 
                885                 890                 895     


Thr Ala Asn Gly Gln Arg Thr Pro Asn Glu Gly Glu Ala Pro Met Glu 
            900                 905                 910         


Thr Glu Glu Ala Pro Thr Leu Glu Pro Ser Asn Gly Met His Arg Asp 
        915                 920                 925             


Gly Gln Asp Ala Gly Ala Arg Met His Ser Ser Ser Thr Arg Ala Leu 
    930                 935                 940                 


Glu Gly Ala Val Glu Asp Glu Pro Lys Val Thr Leu Pro Asp Lys Asp 
945                 950                 955                 960 


Glu Pro His Ala Ser Ala Leu Cys Gly Glu Arg Glu Lys Gln Arg Gln 
                965                 970                 975     


Ser Phe Phe Ser Ser Val Ser Ser Arg Glu Asp Ala Gln Asp Glu Asp 
            980                 985                 990         


Ser Arg Trp Cys Val Ala Gly Gly  Met Tyr Asn Gly Trp  Lys Gly Thr 
        995                 1000                 1005             


Tyr Asp  Val Trp Ile Tyr Arg  Arg Val Ser Ala Ala  Leu Arg Glu 
    1010                 1015                 1020             


Gly Lys  Gly Glu Glu Glu Lys  Arg Arg Glu Gly Glu  Lys Arg Lys 
    1025                 1030                 1035             


Thr Gly  Lys Gly Lys Gln Ser  Val His Thr Ala Ser  Leu Gly Ala 
    1040                 1045                 1050             


Gly Gly  Ala Gln Gly Leu Ser  Pro Gly Glu Thr Gln  Ala Ser Gly 
    1055                 1060                 1065             


Leu Ala  Pro Gly Ser Thr Pro  Leu Gly Ser Ala Gly  Thr Leu Ser 
    1070                 1075                 1080             


Ala Gly  Arg Asn Gly Glu Glu  Thr Arg Glu Ser Thr  Gly Ser Pro 
    1085                 1090                 1095             


Ala Gly  Ala Phe Ala Ser Ser  Ser Ser Leu Ala Ala  Lys Gly Gln 
    1100                 1105                 1110             


Asn Gly  His Ala Ser Val Glu  Asp Leu Lys Thr Gln  Lys Glu Glu 
    1115                 1120                 1125             


Ser Leu  Gly Cys Val Leu Ser  Ala Ser Ala Leu Pro  Leu Asn Pro 
    1130                 1135                 1140             


His Ser  Gly Glu Thr Arg Glu  Asp Ser Ala Gly Arg  Asp Glu Glu 
    1145                 1150                 1155             


Lys Gly  Glu Glu Arg Glu Arg  Asp Glu Asn Glu Pro  Pro Leu Tyr 
    1160                 1165                 1170             


Glu Trp  Arg Val Lys Arg Phe  Ser Ala Leu Ile His  Gly His Glu 
    1175                 1180                 1185             


Lys Ala  Ser Arg Leu Ala Cys  Lys Tyr Cys Val Tyr  Leu Glu Arg 
    1190                 1195                 1200             


Phe Gly  Arg Ile Arg Gly Arg  Leu Ser Ile Cys Ser  Thr Cys Cys 
    1205                 1210                 1215             


Arg Asp  Ala Cys Ser Gly Cys  Met Pro Ser Lys Lys  Arg Ala Ala 
    1220                 1225                 1230             


Gly Ala  Asp Phe Ser Pro His  Cys Arg Asn Gly Arg  Asp Ala Gly 
    1235                 1240                 1245             


Val Gly  Gly Ala Gly Arg Ala  Pro Lys Arg Arg Val  Gln Ala Lys 
    1250                 1255                 1260             


Lys Gly  Ala Ala Gly Ala Ala  Gly Val Cys Gly Asp  Arg Ala Arg 
    1265                 1270                 1275             


Lys Gly  Lys Gly Glu Asp Glu  Pro Glu Arg Asp Gly  Leu Asp Arg 
    1280                 1285                 1290             


Arg Glu  Glu Gly Gly Thr Pro  Ser Ser Lys Gln Thr  Ala Glu Arg 
    1295                 1300                 1305             


Arg Gly  Ala Ala Lys Lys Glu  Gly Arg Glu Glu Asp  Asp Arg Val 
    1310                 1315                 1320             


Asp Gly  Lys Gly Thr Ser Leu  Ser Leu Glu Asn Asn  Ser Phe Glu 
    1325                 1330                 1335             


Ser Ser  Cys Pro Ala Met Arg  Ser Ser Leu Arg Ala  Ser Phe Glu 
    1340                 1345                 1350             


Val Lys  Gly Pro Leu Ser Pro  Ser Ser Ala Asp Asp  Arg Pro Asn 
    1355                 1360                 1365             


Glu Gly  Ala Ala Gly Arg Gly  Ala Pro Pro Gly Ser  Glu Gly Pro 
    1370                 1375                 1380             


Ser Arg  Asp Leu Ala Leu Arg  Ser His Ser Phe Ser  Ser Ala Ser 
    1385                 1390                 1395             


Ser Ser  Arg Lys Ser Ala Lys  Asn Ala Ala Glu Ser  Leu Arg Arg 
    1400                 1405                 1410             


Ile Ala  Gly Pro Leu Phe Arg  Ser Ser Gly Asp Leu  Thr Ala Ser 
    1415                 1420                 1425             


Gln Leu  Gly Ala Glu Thr Glu  Glu Ser Asp Val Leu  Gln Asp Val 
    1430                 1435                 1440             


Phe Glu  Leu Tyr Ser Glu Ala  Gly Glu Ala Trp Glu  Thr Cys Thr 
    1445                 1450                 1455             


Thr Pro  Val Ser Phe Ser Pro  Ser Leu Ser Val Ala  Ser Arg Asp 
    1460                 1465                 1470             


Thr Leu  Val Val Leu Gly Gly  Ser Gln Thr Thr Ala  Val Ala Arg 
    1475                 1480                 1485             


Leu Asp  Ser Gly Lys Met Ser  Glu Ala Val Arg Arg  Ser Ser Asn 
    1490                 1495                 1500             


Ala Leu  Ser Ala Ala Ala Ser  Ser Phe Pro Lys Gly  Lys Gly Phe 
    1505                 1510                 1515             


Gly Gly  Ala Ser Lys Lys Thr  Asp Ser Val Thr Leu  Ser Phe Leu 
    1520                 1525                 1530             


Ala Arg  Val Cys Arg Asn Leu  Arg Met Phe Leu Leu  Leu Cys Gln 
    1535                 1540                 1545             


His Asn  Thr Val Ala Gly Gly  Leu Pro Gly Asp Ser  Lys Cys Val 
    1550                 1555                 1560             


Cys Arg  Ala Gln Ser Gly Pro  Gly Gly Ala Gly Leu  Ala Gly Ala 
    1565                 1570                 1575             


Asp Gly  Arg Ala Pro Gly Asp  Leu Gly Asp Ser Lys  Gly Thr Ala 
    1580                 1585                 1590             


Ile Ala  Arg Gly Pro Gly Gly  Ala Ala Gly Arg Ala  His Gly Ser 
    1595                 1600                 1605             


Glu Pro  Trp Ala Ser Pro Asn  Tyr Thr Gly Gly Pro  Phe Phe Pro 
    1610                 1615                 1620             


Pro Ala  Gly Ser Ala Pro Ser  Gly Trp Pro Pro Val  Ala Gln Ala 
    1625                 1630                 1635             


Asn Ser  Arg Pro Glu Val Leu  Ser Ala Ile Gln Gly  Ala Gln Gly 
    1640                 1645                 1650             


Gln Gly  Pro His Val Ala His  Ser Leu Arg Leu Ala  Ala Ser Leu 
    1655                 1660                 1665             


Ser Pro  Ala Gln Thr Thr Ser  Glu Ser Phe Leu Ala  Pro Glu Ser 
    1670                 1675                 1680             


Phe Ala  Ala Gly Val Arg Pro  Leu Leu Glu Gly Ser  Leu Ser Val 
    1685                 1690                 1695             


Leu Ile  Pro Glu Glu Pro Gln  Val Gly Leu Gly Pro  Ser Ala Gly 
    1700                 1705                 1710             


Gln Gln  Leu Ala Ser Ser Ser  Leu Ser Pro Gly Val  Ser Val Lys 
    1715                 1720                 1725             


Ala Glu  Pro Ser Ser Tyr Phe  Gln Ser Ala Gln Gly  Thr Cys Arg 
    1730                 1735                 1740             


Asp Val  Ser Ala Gly Ala Arg  Thr Ala Met Pro Ser  Ser Phe Leu 
    1745                 1750                 1755             


Glu Gln  Gly Arg Pro Gly Ala  Ala Pro Gly His Ala  Pro Ser Gly 
    1760                 1765                 1770             


Val Gly  Arg Cys Pro Pro Gln  Gly Arg Asp Ala Ser  Pro Gly Cys 
    1775                 1780                 1785             


Pro Gly  Phe Arg Thr Pro Pro  Ala Gly Phe Asp Gly  Pro Ser Ser 
    1790                 1795                 1800             


Ser Gly  Ala Gly Tyr Ser Leu  Ser Pro Tyr Gly Tyr  Pro Gly Thr 
    1805                 1810                 1815             


Glu Ile  Ser Pro His Leu Ala  Pro Phe Phe Pro Glu  Pro Tyr Arg 
    1820                 1825                 1830             


Arg Phe  Arg Glu Ser Arg Gly  Gly Pro Ala Trp Ile  His Ser Pro 
    1835                 1840                 1845             


Gly Ser  Val Asp Val Pro Ser  Ser Gly Leu Gln Ser  Pro Phe Thr 
    1850                 1855                 1860             


Gly Phe  His Ala Thr Ser Gly  Ser Ser Pro Pro Arg  Leu Gly Pro 
    1865                 1870                 1875             


Ser Glu  Gly Ala Ser Phe Ala  Glu Ala Ser Pro Arg  Ala Leu Ala 
    1880                 1885                 1890             


Gly Asp  Leu Gly Pro Ala Gly  Phe Leu Gly Ala Ser  Ala Gly Ala 
    1895                 1900                 1905             


Pro Ala  Ala Glu Gly Arg Gly  Pro Leu Phe Asp Pro  Ser Ala Glu 
    1910                 1915                 1920             


Gly Glu  Gly Lys Phe Ala Pro  Asp Ala Gly Ala Leu  Gly Thr Val 
    1925                 1930                 1935             


Glu Gly  Pro Ala Asp Cys Arg  Thr Gln Gly Glu Thr  Gly Arg Thr 
    1940                 1945                 1950             


Ala Asp  Glu Asp Glu Lys Lys  Lys Ala Lys Lys Ala  Lys Lys His 
    1955                 1960                 1965             


Gly Arg  Ile Thr Asp Ile Glu  Glu Arg Leu Ala Arg  Glu Glu Pro 
    1970                 1975                 1980             


Tyr Asp  Val Val Glu Glu Gly  Asp Asp Pro Glu Pro  Thr Arg Gln 
    1985                 1990                 1995             


Leu Gly  Leu Glu Ala Thr Glu  Lys Glu Gln Asp Val  Pro Arg Ser 
    2000                 2005                 2010             


Gly Asp  Ser Lys Ser Pro Asp  Gln Asp Ser Pro Gly  Gln Pro Ala 
    2015                 2020                 2025             


Asp Ile  Met His Gly Tyr Phe  Lys Ala Arg Val Arg  Asn Arg Arg 
    2030                 2035                 2040             


Val Lys  Asp Gly Leu Leu Leu  Arg Met Thr Ala Val  Leu Val Gly 
    2045                 2050                 2055             


Lys Gly  Phe Tyr Asp Leu Glu  Thr Val Glu Pro Gly  Ala Pro Arg 
    2060                 2065                 2070             


Arg Arg  Gly Gly Trp Gly Glu  Ser Gly Glu Glu Glu  Glu Glu Ser 
    2075                 2080                 2085             


Glu Thr  Lys Tyr Leu Phe Ser  Asn Pro Ala Ser Gln  Lys Pro Cys 
    2090                 2095                 2100             


Asp Phe  Ile Leu Tyr Phe Asp  Thr Arg Glu Asn Arg  Asp Ala Ser 
    2105                 2110                 2115             


Val Ala  Ile Leu Asn Gln Ala  Leu Pro Ala Pro Pro  Pro Arg Leu 
    2120                 2125                 2130             


Pro Pro  Lys Asn Gly Glu Ser  Gln Ala Arg Arg Thr  Leu Arg Gln 
    2135                 2140                 2145             


Leu Tyr  Asp His Phe Leu Glu  Pro Lys Cys Gln Cys  Leu Glu Asp 
    2150                 2155                 2160             


Lys Thr  Leu Lys Val Lys His  Gly Val Ile Asn Leu  Leu Gly Phe 
    2165                 2170                 2175             


Pro Arg  Leu Tyr Val Lys Leu  His Cys Ser Met Ser  Trp Asp Glu 
    2180                 2185                 2190             


Arg Leu  Ser Leu Phe Ser Ser  Phe Leu His Trp Leu  Cys Arg Glu 
    2195                 2200                 2205             


Asp Asp  Ser Gln Pro Pro Pro  Trp Ser Ser Pro Glu  Leu His Pro 
    2210                 2215                 2220             


Glu Leu  Leu Ala Tyr Leu Val  Asp Leu Gly Arg Lys  Gly Phe Ala 
    2225                 2230                 2235             


Ser Gly  Gly Ala Ala Thr Thr  Ala Val Val Asn Ala  Pro Asp Leu 
    2240                 2245                 2250             


Pro Leu  Asp Asp Ser Ala Leu  Ser Lys Lys Asn Ala  Ala Leu Ile 
    2255                 2260                 2265             


Arg Ala  Tyr Met Gln Gln Asp  Thr Gly Ala Ser Gly  Pro Ser Gly 
    2270                 2275                 2280             


Ser Val  Gly Ala Thr Ser Ser  Asp Pro Glu Ala Pro  Arg Lys Asp 
    2285                 2290                 2295             


Asp Glu  Ala Glu Glu Gly Glu  Lys Asp Asp Ser Asn  Ala Ala Leu 
    2300                 2305                 2310             


Val Glu  Gly Pro Ala Pro Glu  Thr Ser Gly Asp Ser  Thr Gly Ala 
    2315                 2320                 2325             


Ala Gln  Pro Cys Gly Lys Gly  Arg Glu Glu Arg Glu  Ala Gly Asp 
    2330                 2335                 2340             


Lys Arg  Gly Pro Gly Asn Glu  Gly Cys Gly Lys Gly  Asp Gly Phe 
    2345                 2350                 2355             


Gly Ser  Pro Val Ala Val Ala  Gly Thr Thr Ala Ala  Pro Gly Glu 
    2360                 2365                 2370             


Thr Glu  Ser Val Ser Cys Pro  Ser Ser Thr Ser Gly  Gly Gly Ala 
    2375                 2380                 2385             


Ser Ser  Ala Leu Ser Ser Gly  Pro Ser Asp Ser Ala  Ala Ala Pro 
    2390                 2395                 2400             


Asp Gly  Cys Glu Ser Ser Pro  Val Ala Leu Glu Ser  Ala Ser Leu 
    2405                 2410                 2415             


Leu Ser  Phe Ser Pro Ser Ala  Ala Arg Ala Glu Val  Leu Thr Val 
    2420                 2425                 2430             


Pro Gly  Val Gly Leu Val Asn  Phe Ser Leu Pro Asp  Gly Val Lys 
    2435                 2440                 2445             


Phe Asp  Lys Ser Lys Leu Ala  Phe Arg Cys Tyr Trp  Arg Glu Gly 
    2450                 2455                 2460             


His Ala  Gly Val Val Thr Val  Gly Ala Gly Ala Ala  Val Ser Pro 
    2465                 2470                 2475             


Ser Ser  Gly Ala Gly Thr Phe  Val Pro Ser Arg Pro  Thr Val Cys 
    2480                 2485                 2490             


Thr Ala  Gln Asn Lys Ser Arg  Thr Phe Ser Cys Arg  Lys Tyr Gly 
    2495                 2500                 2505             


Leu Tyr  Gln Ser Arg Val Leu  Ala Leu Gln Ala Arg  Leu Leu Ser 
    2510                 2515                 2520             


Glu Leu  Leu Trp Pro Gln Pro  Pro Ser Pro Ala Arg  Leu Arg Val 
    2525                 2530                 2535             


Ser Ala  Met Ala Ala Val Val  Tyr Gly Leu Ile Ala  Ala Pro Met 
    2540                 2545                 2550             


Pro Phe  Thr Asp Pro Trp Gln  Ala Val Cys Gly Val  Ser Val Ala 
    2555                 2560                 2565             


Glu Asp  Ala Leu Arg Gln Arg  Arg Glu Val Trp Lys  Asn Leu Leu 
    2570                 2575                 2580             


Asp Pro  Arg Gln Arg Arg Pro  Ala Pro Ala Pro Ile  Ser Gln Leu 
    2585                 2590                 2595             


Ser Leu  Pro Pro Val Ser Gly  Pro Pro His Ala Ser  Ser Ala Thr 
    2600                 2605                 2610             


Gln Glu  Leu Pro Asn Arg Pro  Gly Thr Pro Trp Pro  Gly Gln Glu 
    2615                 2620                 2625             


Thr Val  Cys Gly Ala Arg Gly  Pro Ala Pro Gly Leu  Ala Ser Ala 
    2630                 2635                 2640             


Trp Ala  Thr Tyr Gly Asn Pro  Gly Asp Arg Asp Ala  Ala Glu Pro 
    2645                 2650                 2655             


Gln Ser  Thr Tyr Val Gly Arg  Gly Pro Ala Gly Ala  Glu Gly Pro 
    2660                 2665                 2670             


Gly Gly  Gly Ile Ala Val His  Arg Glu Trp Ala Arg  Asn Ser Gly 
    2675                 2680                 2685             


Ser Glu  Ala Ala Gln Pro Cys  Gln Phe Gly Arg Ala  Val Glu Arg 
    2690                 2695                 2700             


Pro Val  Pro Gly Pro Gln Ser  Ser Leu Gly Pro Gly  Gly Asp Asn 
    2705                 2710                 2715             


Arg Gly  Asp His Met Ala Tyr  Asp Gln Ser Pro Ala  Gly Pro Ala 
    2720                 2725                 2730             


Ser Asn  Ala Pro Gly Pro Thr  Pro Pro Phe Val Gly  Pro Phe Ser 
    2735                 2740                 2745             


Pro Gly  Leu Val Leu Arg His  Gly Pro Pro Ala Phe  Ser Gln Asp 
    2750                 2755                 2760             


Pro Ser  Leu His Arg Pro Pro  Phe Ala Ala Gly Thr  Gly Pro Ala 
    2765                 2770                 2775             


Gly Gln  Arg Leu Ala Ser Asp  Ser Pro Tyr Pro Leu  Lys Asn Glu 
    2780                 2785                 2790             


Ala Ser  Pro Gln Leu Ala Met  Ala His Ala Pro Gly  Phe Glu Asn 
    2795                 2800                 2805             


Ser Asp  Gly Phe Gln Gly Glu  Gln Pro Leu Ala Lys  Gln Arg Lys 
    2810                 2815                 2820             


Ile Glu  Gly Ala Ser Asp Arg  Pro Val Pro Asp Glu  Gly Gln Val 
    2825                 2830                 2835             


Leu Gly  Thr Ile Ser His Gly  Lys Ser Pro Ala Ala  Arg Pro Val 
    2840                 2845                 2850             


Asp Gly  Asp Phe Ala Pro Asp  Gly Arg Ser Pro Leu  Phe Ser Gln 
    2855                 2860                 2865             


Asp Ala  Ser Gly Val Gly Gly  Gly Arg Pro Ser Gly  Val Gly Gly 
    2870                 2875                 2880             


Gln Leu  Ala Ala Gly Gly Lys  Gly His Phe Ala Thr  Ala Pro Phe 
    2885                 2890                 2895             


Gly Ser  Gly Thr Leu Pro Thr  Thr Arg Gly Pro Ser  Gln Pro Gly 
    2900                 2905                 2910             


Gly Asp  Gly Leu Ser His Arg  Ser Gly Thr Glu Pro  Ala Ala Ala 
    2915                 2920                 2925             


Tyr Ser  Ser Pro Ala Gly Ala  Ala Tyr Pro Ser Ala  Ser Asn Ala 
    2930                 2935                 2940             


Ser Pro  Ile Tyr Gly Ala Ala  Pro Lys Arg Glu Gly  Asp Ser Pro 
    2945                 2950                 2955             


Phe Gly  Pro Ala Pro Pro Ser  Gly Tyr Cys Arg Pro  Gly Ser Pro 
    2960                 2965                 2970             


Ala Val  Asp Pro Lys Leu Pro  Gly Ser Val Pro Ser  Ser Gly Asn 
    2975                 2980                 2985             


Leu Asp  Ser Val Asn Tyr Gly  Ser Phe Phe Pro Gly  Gln Gln Ala 
    2990                 2995                 3000             


Pro Gln  Gly Asp Gly Arg Ile  Ala Pro Trp Gly Ser  Gly His Val 
    3005                 3010                 3015             


Gly Ala  Pro Arg Gly Glu Ala  Arg Gly Ser Glu Arg  Val Gly His 
    3020                 3025                 3030             


Ala Gly  Ala Ser Arg Gly Leu  Thr Gly His Glu Leu  Glu Glu Gly 
    3035                 3040                 3045             


Gln Gly  Gly Pro Gly Glu Glu  Gly Ala Gly Arg Glu  Arg Gln Arg 
    3050                 3055                 3060             


Lys Arg  Arg Lys Ser Ala Met  Ser Met Ser Ser Gln  Gly Glu Asn 
    3065                 3070                 3075             


Thr Pro  Leu Phe Ala Pro Thr  Ser Leu Pro Pro Val  Pro Phe Ala 
    3080                 3085                 3090             


Ser Gly  Asp Ser Leu Ala Asp  Gly Ser Gly Ser Asp  Phe Gly Gln 
    3095                 3100                 3105             


Gln Leu  Gly Pro Pro Phe Ser  His Gly Ser His Ala  Pro Pro Phe 
    3110                 3115                 3120             


Pro Glu  Ala Asn Ala Val Gly  Ser Gln His Phe Thr  Ala Asp Asn 
    3125                 3130                 3135             


Leu Glu  Thr Pro Gly Leu Pro  Ala Glu Leu Gly Gly  Gly Asp Gly 
    3140                 3145                 3150             


Arg Arg  Gln Ser Gly Ser Thr  His Glu Glu Val Ser  Gly Pro Arg 
    3155                 3160                 3165             


Ala Gly  Gly Glu Lys Gly Glu  Phe Ser Leu Glu Gly  Ala Pro Gln 
    3170                 3175                 3180             


Ala Ala  Ala Gln Gln Leu Ser  Ala Glu Thr Leu Thr  Phe Leu Leu 
    3185                 3190                 3195             


Gly Thr  Asn Val Val Trp Glu  Glu Asn Glu Lys Arg  Trp Arg Val 
    3200                 3205                 3210             


Gln Val  Arg Pro Pro Ser Pro  Arg Gly Cys Asp Gly  Glu Gly Ala 
    3215                 3220                 3225             


Asp Gly  Lys Leu Gly Gly Glu  Lys Lys Lys Arg Lys  Arg Asp Gly 
    3230                 3235                 3240             


Phe Ser  Ala Gly Gly Glu Arg  Arg Arg Ser Ser Thr  Gly Asn Glu 
    3245                 3250                 3255             


Pro Asp  Asp Gln His Lys Ala  Gly Thr Leu Glu Trp  Val Ser Met 
    3260                 3265                 3270             


Ala Gln  Leu His Gln Ala Gln  Lys Leu Gln Asn Gln  Leu Val Gly 
    3275                 3280                 3285             


Lys Met  Glu Arg Gly Lys Gly  Glu Gly Gly Asp Glu  Glu Arg Leu 
    3290                 3295                 3300             


Gly Gly  Asp Gly Arg Gly Asn  Ile Phe Phe Asp Ala  Asn Gly Ser 
    3305                 3310                 3315             


Asp Glu  Asn Ala Lys Lys Ala  Ala Leu Leu Lys Ala  Arg Arg Trp 
    3320                 3325                 3330             


Leu Arg  Arg Arg Ile Val Gln  Gly Gln Ile Leu Val  Thr Gly Leu 
    3335                 3340                 3345             


Ser Arg  Asp Gly Leu Phe Ser  Ser Arg Pro Asp Glu  Pro Glu Arg 
    3350                 3355                 3360             


Ser Ser  Ser Val Ser Thr Gly  Ala Phe Thr Gly Ser  Ser Pro Asn 
    3365                 3370                 3375             


Asp Lys  Pro Thr Asp Leu Asn  Ala Ala Val Pro Pro  Leu Ser Pro 
    3380                 3385                 3390             


Phe Phe  Ser Pro Ile Pro Phe  Gly Ala Thr Thr Ala  Pro His Arg 
    3395                 3400                 3405             


Pro Ser  Pro Gly Phe Tyr Pro  Pro Ala Pro Ala His  Pro Thr Glu 
    3410                 3415                 3420             


Asp Gly  Cys Arg Pro Pro Met  Pro Ala Pro Val Pro  Met His Ala 
    3425                 3430                 3435             


Pro Gln  Gly Pro Val Asp Ser  Arg Thr Tyr Arg Gly  Ala Arg Pro 
    3440                 3445                 3450             


Val Tyr  Pro Gly Ser Asp Val  Thr Pro Gln Thr Cys  His Gly Val 
    3455                 3460                 3465             


Arg Pro  Glu Ser Met Gln Glu  Glu Gly Arg Ala Ala  Leu Leu Ala 
    3470                 3475                 3480             


Glu Gln  Gly Ser Ala Phe Phe  Val Ser Gly Asp Gly  Lys Gly Asp 
    3485                 3490                 3495             


Asn Arg  Gly Ala Thr Val Gly  Gln Ile Arg Gln Gly  Thr Val Arg 
    3500                 3505                 3510             


Val Met  Gln Ser Gln Thr Ala  Ser Gln Ser Leu Asp  Gln Gly Phe 
    3515                 3520                 3525             


Asp Leu  Pro His Pro Pro Ala  Pro Gly Pro Ala Tyr  Arg Gly Val 
    3530                 3535                 3540             


Pro Val  Gly His Gly Pro Ser  Gly Pro Tyr Tyr Leu  Asn Gly Gly 
    3545                 3550                 3555             


Cys Val  Ala Gln Arg Pro Tyr  Ala Thr Phe Ser Asn  Leu Ala Gly 
    3560                 3565                 3570             


Pro Val  Gln Gly Ser Phe Pro  Pro Leu Glu Phe Ser  Asn Gly Gly 
    3575                 3580                 3585             


Leu Pro  Thr Thr Ala Leu Gly  Arg Arg Gly Ser Asp  Ser Gly Pro 
    3590                 3595                 3600             


Gln Gly  Ala Gly Arg Asn Ala  Ser Gln Met Gln Pro  Gly Phe Ala 
    3605                 3610                 3615             


Ser Arg  Pro His Gly Pro Glu  Arg Leu Gly Arg Glu  Ser Ala Pro 
    3620                 3625                 3630             


Gln Ser  Gly Ala Pro Pro Gly  Phe Ser Pro His Ala  His Gly Arg 
    3635                 3640                 3645             


Gly Glu  Arg Asp Arg Pro Ser  Phe Ser Gly Ala Thr  Thr Met Pro 
    3650                 3655                 3660             


Leu Ala  Ser Leu Thr Ala Phe  Ser His Pro Ala Ala  Gly Pro Met 
    3665                 3670                 3675             


Phe Val  Gly Thr Glu Gly Arg  Gly Gln Gln Gly Asp  Ile His Pro 
    3680                 3685                 3690             


Asn Leu  Cys Gly Val Ala Pro  Val Gly Gly Pro Arg  Gly Pro Ala 
    3695                 3700                 3705             


His Ala  Pro Met Pro Ala Tyr  Gly Pro Gly Gly Ala  Ala Gly Pro 
    3710                 3715                 3720             


Pro Arg  Asp Asp Arg Arg Ala  Glu Gly Gly Ala Pro  Gly Val Ser 
    3725                 3730                 3735             


His Ser  Asp Ile Phe Leu Ala  Asn Asp Arg Arg Leu  His Pro Glu 
    3740                 3745                 3750             


Met Cys  Leu His Ser Ala Pro  Ser Trp Gly Pro Ala  Gly Thr Phe 
    3755                 3760                 3765             


Ala Ser  Pro Asp Asn Arg Gln  Asn Ala Glu Pro Trp  Pro Ala Ala 
    3770                 3775                 3780             


His Ala  Ser Ser Asn Asn Phe  Phe Asp Tyr Thr Gly  Val Asn Met 
    3785                 3790                 3795             


Pro Ala  Ala Gly Pro Pro Ile  Gln Leu Asp Trp Ser  Lys Val Arg 
    3800                 3805                 3810             


Gly Ala  Gly Gly 
    3815         


<210>  16
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Arg Ala Gly Leu Leu Phe Leu Arg Gly Ala Ala Gly Pro Gly 
1               5                   10                  15      


Pro Leu Lys Cys Phe Gly Pro Arg Val Glu Ala Phe Ser Gly Ser Ile 
            20                  25                  30          


Ser Leu Leu Ser Leu Asp Ser Arg Gly Pro Thr Pro Phe Arg Thr Pro 
        35                  40                  45              


Phe His Thr Thr Ser Ala Leu Ser Lys Ser Arg Gln Pro Pro Lys Glu 
    50                  55                  60                  


Ser Pro Glu Ser Ala Ala Ala Cys Thr Phe Ser Pro Leu Phe Pro Ser 
65                  70                  75                  80  


Pro Val Arg Ala Ser Pro His Arg Asn Leu Leu Gly Ala Arg Val Ser 
                85                  90                  95      


Val Pro Cys Lys Pro Leu Ala Cys Val Gly Ala Pro Lys Arg Arg His 
            100                 105                 110         


Gly Glu Thr Ser Asp Gly Phe Ser Ser Arg Ala Ala Val Ala Ala Glu 
        115                 120                 125             


Ala Leu Pro Pro Trp Pro Ser Asp Phe Leu Gln Ser Glu Glu Ile Ala 
    130                 135                 140                 


Val Asp Ser Pro Gln Lys Pro Thr Gly Phe Ser Arg Pro Ser Asn Ala 
145                 150                 155                 160 


Arg Val Ser Pro Ala Pro Asn Ala Trp Glu Ala Ala Ala Val Phe Arg 
                165                 170                 175     


Arg Leu His Ala Phe Asp Ser Gly Leu Arg Gly Asp Ala Ser Gly Ala 
            180                 185                 190         


Phe Ala Ala Ser Ala Thr Cys Gly Cys Leu Ala Ala Ala Ser Arg Arg 
        195                 200                 205             


Asn Pro Cys Leu Pro Ala Tyr Gln Leu Ser Trp Asn Leu Leu Gln Ala 
    210                 215                 220                 


Arg Met Phe Gly Gly Arg Ala Gly Gly Leu Lys Arg Arg Lys Pro Arg 
225                 230                 235                 240 


Arg Asp Pro Gly Arg Val Ile Gln Ser Gly Met Gly Arg Arg Gln Glu 
                245                 250                 255     


Phe Phe Trp Pro Glu Lys Ala Arg Arg Thr Arg Val Pro Leu Tyr Gln 
            260                 265                 270         


Asn Ser Arg Pro Asn Leu Val Tyr Asp Gln Arg Phe Arg Arg Phe Met 
        275                 280                 285             


Cys Met Trp Tyr Ala Asn Gly Val Gln Val Phe Arg Pro Phe Ser Cys 
    290                 295                 300                 


Arg Gly Arg Arg Gly Gly Arg Gly Lys Glu Gly Leu Pro Asp Gly Leu 
305                 310                 315                 320 


Gly Ile Gly Arg Gly Ser Gly Thr Trp Glu Arg Ala Arg Ala Lys Ala 
                325                 330                 335     


Val Val Leu Leu Lys Gln Leu Gln Arg Gln Gly His Leu Asp Arg Leu 
            340                 345                 350         


Ala Lys Pro Asp Val Thr Arg Ser Gly Val Arg Gly Val Tyr Phe Asp 
        355                 360                 365             


Thr Glu Glu Lys Leu Trp Val Ala Thr Trp Asn Glu His Gly Leu Arg 
    370                 375                 380                 


Arg Phe Lys Ala Phe Pro Thr Met Glu Met Gly Phe Asp Ala Ala Tyr 
385                 390                 395                 400 


Gln Ala Ala Val Ala Val Arg Arg Gln Lys Leu Arg Glu Asn Tyr Ile 
                405                 410                 415     


Phe Ser Met Gln Arg Asn Arg Lys Lys Ser Gly Arg Pro Pro Phe Lys 
            420                 425                 430         


<210>  17
<211>  1919
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Leu Pro Asp Gln Ala Ala Tyr Gly Arg Gln Leu Ala Lys Arg 
1               5                   10                  15      


Arg Arg Leu Ser Ala Ser Glu Glu Glu Ala Thr Leu Ala Ser Lys Asn 
            20                  25                  30          


Asp Gly Lys Glu Gly Leu Gln Glu Pro Ala Gly Ala Thr Ala Gly His 
        35                  40                  45              


Leu Leu Pro Ala Glu Glu Pro Gly Gln Tyr Thr Pro Glu His Thr Glu 
    50                  55                  60                  


Gly Arg Arg Glu Phe Arg Arg His Pro Val Val Leu Pro Gly Gly Gly 
65                  70                  75                  80  


Arg Lys Ala Ala Ser Tyr Gly Leu Ile Ala Val Gly Gly Gly Asp Ser 
                85                  90                  95      


Leu Arg Ala Ser Arg Arg Thr Arg Ser Ser Ala Ser Ile Glu Thr Ser 
            100                 105                 110         


Ala Glu Glu Lys Glu Thr Tyr Thr Ser Pro Glu Leu Gly Pro Gly Ala 
        115                 120                 125             


Ser Trp Ser Val Ser Thr Val Lys Gly Ser Lys Gly Arg Ser Asp Glu 
    130                 135                 140                 


Glu Gly Arg Ala Gly Lys Arg Ala Gly Ala Cys Ala Ala Arg Asp Ser 
145                 150                 155                 160 


Ala Ala Gly Ser Arg Thr Leu Ala Gln Ala His Arg Gly Ala Asp Glu 
                165                 170                 175     


Glu Arg Met Pro Pro His Ser Pro Ala Arg Asp Gly Ser His Gln Val 
            180                 185                 190         


Cys Trp Asp Ser Asp Ala Leu Pro Ser Pro Tyr Asp Leu Gly Leu Ser 
        195                 200                 205             


Glu Ala Asp Asp Glu Glu Val Ser Pro Gln Lys Glu Ala Leu Ala Glu 
    210                 215                 220                 


Lys Asn Gly Leu Val Leu Phe Ala Glu Gln Ser Leu Gln Gly Val Gly 
225                 230                 235                 240 


Leu Ala Thr Leu Thr Val Pro Ser Gly Ala Thr Ser Ser Lys Gly Ala 
                245                 250                 255     


Phe Ser Ala Gly Ser Pro Phe Leu Pro Gly Ser Gly Thr Thr Ala Ser 
            260                 265                 270         


Pro Arg Ser Pro Val Pro Arg Gly Asp Lys Ser Leu Gly Asp Gly Ser 
        275                 280                 285             


Val Gly Ser Asp Asp Val Ser Ala Lys Ala Ser Pro His Ala His His 
    290                 295                 300                 


Asn Val Thr Ala Gly Ala Asp Ala Ser Gln Ser Ser Glu Asp Ala Phe 
305                 310                 315                 320 


Phe Pro Ala Ala Pro Pro Gly Gly Val Pro Gly Thr Leu Thr Val Glu 
                325                 330                 335     


Asp Leu Leu Thr Met Pro Glu Arg Arg Gln Asp Pro Glu Ala Glu Lys 
            340                 345                 350         


Ala Ala Lys Thr Asp Phe Asp Cys Leu Ala Ala Leu Ile Gln Asp Ala 
        355                 360                 365             


Leu Gly Glu Ala Gly Gly Ala Ala Gly Arg Val Ala Pro Lys Arg Arg 
    370                 375                 380                 


Cys Arg Thr Leu Gly Ala Gly Phe Asn Pro Thr His Ser Ala Arg Pro 
385                 390                 395                 400 


Gly Ser Gly Ser Val Ala Gly Leu Glu Ala Pro Gly Ala Leu Gly Arg 
                405                 410                 415     


Glu Leu Asp Ala Leu Val Ala Gly Gly Ser Pro Glu Glu Ser Arg Ala 
            420                 425                 430         


Asp Leu Glu Pro Asp Gly Gln Ala Ala Gly Ala Ser Trp Gln Glu Ser 
        435                 440                 445             


Leu His Leu Gln Tyr Asp Thr Arg Asn Gly Gly Thr Tyr Glu Glu Asp 
    450                 455                 460                 


Leu Asp Ser Ala Ser Leu Ser Phe Leu Leu Gly His Ser Glu Gly Ser 
465                 470                 475                 480 


Glu Lys Gly Pro Ala Leu Ser Ala Ser Ala Gly Ala Ser Thr Ala Ala 
                485                 490                 495     


Ser Val Ser Ser Phe Phe Pro Ser Glu Ala Ala Cys Gly Val Tyr Ala 
            500                 505                 510         


Pro Gly Gln His Gly Arg Pro Thr Gln Ser Gln Asp Pro Ala Lys Glu 
        515                 520                 525             


Arg Gln Arg Arg Leu Ala Arg Asp Arg Glu Thr Leu Asn Leu Ser Ala 
    530                 535                 540                 


Gln Ile Ala Ala Arg Phe Lys Ser Cys Arg Thr Glu Asp Val Met Arg 
545                 550                 555                 560 


Leu Phe Arg Arg Tyr Leu Ala Val Ser Ser Arg Gln Val Arg Asp Pro 
                565                 570                 575     


Ala Thr Leu Glu Arg Val Val Ala Ala Cys Cys Tyr Ile Ser Ser Arg 
            580                 585                 590         


Gln Ala Met Asp Gly Leu Ser Leu Ser Asp Ile Cys His Glu Met Asp 
        595                 600                 605             


Ala Ser Asn Gly Gln Asp Leu Phe Ala Ala Gly Cys Glu Ala Arg Gly 
    610                 615                 620                 


Lys Lys Leu Ala Asp Gly Glu Gly Met Gly Arg Gly Glu Ser Asp Arg 
625                 630                 635                 640 


Glu Arg Ala Gly Gly Ala His Ala Ser Met Arg Cys Lys Ser Leu Gly 
                645                 650                 655     


Lys Trp Val Val Arg Ile Cys Arg Lys Leu Gln Leu Gln Ala Leu Pro 
            660                 665                 670         


Asp Lys Asp Asp Asp Pro Glu Glu Arg Ala Asn Arg Val Leu Ala Arg 
        675                 680                 685             


Val Lys Gln Leu Leu Ile Ala Lys Met Glu Glu Glu Glu Gln Arg Arg 
    690                 695                 700                 


Pro Gln Leu Val Asn Ala Phe Val Arg Ala Thr Gln Ser Ala Val Glu 
705                 710                 715                 720 


Lys Gln Arg Leu Lys Ala Glu Gly Asp Arg Ser Glu Ala Asp Ser Leu 
                725                 730                 735     


Ala Ser Leu Glu Ser Leu Leu Gly Asp Glu Ala Arg Arg Ala Asp Ala 
            740                 745                 750         


Arg Ala Asp Ala Glu Ala Arg Arg Gln Thr Pro Ala Glu Ala Gln Leu 
        755                 760                 765             


Gly Asp Phe Leu Asp Gly His Gln Gly Gly Glu Lys Thr Gly Arg Val 
    770                 775                 780                 


Ser Ser Ala Arg Ile Asn Gly Arg Ala Ala Glu Ala Ser Pro Ala Pro 
785                 790                 795                 800 


Pro Ala Pro Gln Gly Ser Thr Ala Pro Ala Asp Ser Thr Pro Ala Ala 
                805                 810                 815     


Gly Ser Glu Glu Arg Gln Ala Leu Asn Ala Ile Glu Glu Leu Leu Ala 
            820                 825                 830         


Gln Val Thr Gly Gly Ser Asn Leu Asp Cys Phe Gly Ser Ala Thr Leu 
        835                 840                 845             


Ala Ala Val Asp Ser Asp Leu Ala Ser Gly Thr Ser His Val Asp Arg 
    850                 855                 860                 


Glu Ser Cys Ala Arg Leu Arg Arg Leu Asp Lys Ser Gly Arg Asp Ala 
865                 870                 875                 880 


Phe Ala Ala Asp Ala Asp Gly Pro Glu Arg Pro Thr Glu Asn Glu Val 
                885                 890                 895     


Glu Pro Glu Ala Arg Pro Gly Ala Ala Gly Val Leu Ala Glu Asp Val 
            900                 905                 910         


Asp Glu Ala Ser Met Ala Leu Thr Pro Asn Pro Asp Asp Arg Ser Ser 
        915                 920                 925             


Ser Ala Ser Gly Asp Ala Ala Glu Pro Val Ala Ser Ile Arg Leu Glu 
    930                 935                 940                 


Gln Arg Glu Glu Lys Asn Gly Asp Ala Ser Gly Leu Ser Leu Asp Ile 
945                 950                 955                 960 


Cys Pro Ser Leu Phe Asp Pro Val Asp Met Pro Ala Leu Ser Ala Ser 
                965                 970                 975     


Ser Glu Gly Asp Ser Gly Asp Ser Ser Pro Phe Ser Pro Ile Leu Thr 
            980                 985                 990         


Ser Leu Leu Ser Ala Ser Leu Pro  Pro Ser Glu Thr Leu  Ala Gln Ala 
        995                 1000                 1005             


Lys Asp  Met Gln Pro Ala Ala  Arg Leu Gln Leu Gln  Arg Phe Thr 
    1010                 1015                 1020             


Trp Leu  Gln Lys Met Arg Ala  Glu Ala Leu Glu Lys  Leu Lys Lys 
    1025                 1030                 1035             


Glu Lys  Glu Ala Val Phe Arg  Gly Leu Val Leu Leu  Gln Arg Ile 
    1040                 1045                 1050             


Leu Gln  Leu Phe Tyr Asp Val  Lys Gln Gly Glu Ser  Asp Gly Glu 
    1055                 1060                 1065             


Arg Glu  Asp Gly Glu Asp Gly  Glu Gly Lys Lys Arg  Gln Lys Gly 
    1070                 1075                 1080             


Trp Thr  Glu Glu Asp Pro Leu  Asp Lys Arg Trp Arg  Ala Arg Gly 
    1085                 1090                 1095             


Arg Cys  Asp Ala Val Ser Leu  Ala Ser Leu Ile Ile  Ile Val Phe 
    1100                 1105                 1110             


Lys Trp  Met Gln Ile Pro Ile  Pro Gln Arg Ile Ala  Leu Asp Ala 
    1115                 1120                 1125             


Leu His  Val Asp Arg Lys Ser  Val Tyr Lys Arg Arg  Leu Glu Gln 
    1130                 1135                 1140             


Met His  Ile Leu Lys Thr Leu  Phe Gly His Leu Arg  Gly Met Val 
    1145                 1150                 1155             


Glu Lys  Lys Asp Gly Ser Ser  Ser Ser Ala Leu Ala  Glu Glu Leu 
    1160                 1165                 1170             


Lys Ala  Ser Leu Pro Pro His  Leu Ala Ser Leu Leu  Gln Gln Val 
    1175                 1180                 1185             


Val Gly  Asn Pro Ala Thr Met  Gln Arg Leu Leu Ala  Leu Ala Asp 
    1190                 1195                 1200             


Glu Glu  Glu Glu Leu Gly Asn  Phe Ile Ser Ser Gln  Ser Leu Gly 
    1205                 1210                 1215             


Ser Asp  Gly Glu Ser Gly Lys  Ala Ser Ala Gly Leu  Gly Gly Val 
    1220                 1225                 1230             


Pro Pro  Pro Ala Ala Ala Ala  Ser Pro Thr Pro Val  Lys Thr Ser 
    1235                 1240                 1245             


Gln Ala  Ser Phe His Pro Gln  Ala Pro Ala Ala Ser  Ser Pro Glu 
    1250                 1255                 1260             


Ser Ser  Ala Pro Ser Val Ala  Val Glu Pro Glu Gln  Asp Ala Ala 
    1265                 1270                 1275             


Ser Ser  Ser Phe Leu Ala Ala  Ile Leu Ala Glu Val  Ala Ala Glu 
    1280                 1285                 1290             


Arg Glu  Val Gly Ala Val Lys  Thr Arg Gly Pro Gly  Asp Ala Glu 
    1295                 1300                 1305             


Arg Thr  Ala Ala Glu Leu Gly  Phe Gln Thr Arg Lys  Lys Arg Arg 
    1310                 1315                 1320             


Val Ser  Glu Leu Asn Ala Gln  Arg Ser Pro Asp Asn  Gly Leu Gly 
    1325                 1330                 1335             


Ser Asp  Leu Tyr Asp Glu Asp  Arg Glu Ala Ser Ser  Ala Val Pro 
    1340                 1345                 1350             


Val Ala  Ser Pro Leu Ala Asn  Leu Cys Ser Ser Leu  Ser Ser Ser 
    1355                 1360                 1365             


Ser His  Arg Asn Pro Ser Glu  Met Ala Ala Val Ala  Ser Val Ala 
    1370                 1375                 1380             


Pro Ser  Pro Arg Ala Ala Arg  His Pro Arg Ala Pro  Asp Glu Met 
    1385                 1390                 1395             


Thr Leu  Gln Gly Leu Ala Val  Gly Lys Asp Ala Gly  Thr Pro Arg 
    1400                 1405                 1410             


Gln Ala  Gly Gly Tyr Ala Gly  Thr Phe Leu Pro Gly  Asp Gly Asp 
    1415                 1420                 1425             


Arg Val  Ser Glu Gly Glu Asp  Gly Arg Ser Glu Arg  Val Arg Ala 
    1430                 1435                 1440             


Arg Phe  Leu Ala Glu Arg Gly  Ser Met Asp Ala Ser  Ser Ser Phe 
    1445                 1450                 1455             


Ala Leu  Gly Phe Ser Leu Ala  Glu Ala Leu Leu Arg  His Gly Phe 
    1460                 1465                 1470             


Cys Leu  Pro Ser Pro Ser Asp  Pro Pro Ala Gly Leu  Ala Asp Ala 
    1475                 1480                 1485             


Gln Phe  Ala Thr Gly Asp Leu  Leu Arg Asp Gly Gly  Ser Ser Ser 
    1490                 1495                 1500             


Gly Glu  Arg Ala Leu Arg Met  Gln Pro Glu Gly Phe  Ser Ala Thr 
    1505                 1510                 1515             


Arg Gly  Ser Arg Pro Ala Val  Ala Pro Gly Pro Ala  Gly Phe Gly 
    1520                 1525                 1530             


Ile Gln  Ala Glu Ala Glu His  Glu Gly Arg Gly Asp  Val Asn Ser 
    1535                 1540                 1545             


Thr Asp  Val Ile Phe Ser Asn  Arg Ala Thr Arg Asp  Ile Ile Ala 
    1550                 1555                 1560             


Ser Phe  Leu Ala Ser Ala Ser  Thr Glu Gly His Pro  Gly Thr Ala 
    1565                 1570                 1575             


Ser Leu  Thr Gly Arg Gly Leu  Glu Asp Gly Arg Ser  Pro Arg Leu 
    1580                 1585                 1590             


Arg Gly  Pro Leu Ala Ala Val  Pro Lys Ala Val Ser  Gln Ala Asp 
    1595                 1600                 1605             


Arg Gly  Pro Gly Arg Phe Asn  Arg Gly Ala Ser Gly  Ser Cys Arg 
    1610                 1615                 1620             


Gln Pro  Ser Ser Arg Ser Pro  Pro Leu Pro Val Ser  Pro Tyr Arg 
    1625                 1630                 1635             


Gly Arg  Thr Gly Asp Ser Ser  Arg Gln Arg Pro Leu  Ser Pro Ser 
    1640                 1645                 1650             


Ser Leu  Phe Ala Ala Ala Ala  Ser Met Ala Gly Val  Leu Pro Gly 
    1655                 1660                 1665             


Pro Leu  Pro Ser Ser Arg Ser  Ala Gly Ser Ser Ala  Leu Ser Pro 
    1670                 1675                 1680             


Gly Val  Glu Arg Ser Pro Arg  Glu Arg Val Ala Ala  Gln Ala Leu 
    1685                 1690                 1695             


Glu Ala  Thr Arg Arg Gly Asp  Val Asp Asp Arg Ser  Leu His Pro 
    1700                 1705                 1710             


Ser Ser  Ser Val Ser Ala Val  Arg Ser Leu Leu Pro  Ala Glu Pro 
    1715                 1720                 1725             


Ala Leu  Gly Gly Ala Ser Pro  Phe Ala Ser Ser Ala  Leu Ala Met 
    1730                 1735                 1740             


Gly Leu  Pro Glu Ala Gly Ala  Ser Gln Ala Gly Ala  Asp Ala Pro 
    1745                 1750                 1755             


Leu Ala  Ser Pro Ser Ile Ala  Leu Ala Thr Val Ala  His Leu Lys 
    1760                 1765                 1770             


Ala Ala  Glu Lys Ala Leu Leu  Asp Ser Val Pro Asp  Ser Ala Arg 
    1775                 1780                 1785             


Val Val  Ser Leu Gln Phe Glu  Arg Thr Gln Gln Arg  Trp Val Cys 
    1790                 1795                 1800             


Lys Trp  Gln Arg His Lys Pro  Ala Gly Ala Pro Ala  Asn Arg Lys 
    1805                 1810                 1815             


Glu Pro  Trp His Arg Arg Cys  Phe Ser Val Ile Lys  Tyr Gly Tyr 
    1820                 1825                 1830             


Glu Gly  Ala His Ala Leu Ala  Ala Ala Val Ala Lys  Lys Leu Arg 
    1835                 1840                 1845             


Asp Gly  Arg Arg Ala Leu Leu  Gln Lys Gln Arg Arg  Leu Glu Glu 
    1850                 1855                 1860             


Glu Gly  Leu Ala Glu Ala Glu  Glu Ala Pro Arg Asp  Glu Glu Glu 
    1865                 1870                 1875             


Val Gly  Asp Ala Glu Asp Glu  Glu Pro Leu Gly Ala  Ala Glu Glu 
    1880                 1885                 1890             


Ala Glu  Glu Thr Val Ser Pro  Arg Val Asp Ala Gly  Gly Asp Arg 
    1895                 1900                 1905             


Ser Ala  Ser Gly Ser Ala Glu  Ala Gly Lys Gln 
    1910                 1915                 


<210>  18
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Cys Val Lys Lys Glu Gly Gly Asp Gly Lys Arg Gly Asn Glu Lys 
1               5                   10                  15      


Asn Gln Val Asn Asp Lys Gly Val Lys Arg Thr Gly Arg Asp Val Glu 
            20                  25                  30          


Ser Arg His Ala Pro Ser Val Pro His Leu Glu Lys Leu Val Asp Met 
        35                  40                  45              


Ala Met Val Tyr Ser Ser Cys Leu Pro Pro Cys Asp Ser Ser Gln Gly 
    50                  55                  60                  


Gly Asp Gly Glu Arg Val Lys Arg Asn Ala Gly Ala Lys Arg Lys Gln 
65                  70                  75                  80  


Gly Gln Gly Glu Ser Gln Asp Arg Leu Lys Ala Leu His Asp Ser His 
                85                  90                  95      


Pro Leu Gln Cys Val Trp Tyr Leu Glu Ser Ser Pro Ala Thr Asn Ile 
            100                 105                 110         


Thr Leu Pro Ser Glu Ser Gly Ser Leu Lys Ser Pro Ser Ser Pro Ser 
        115                 120                 125             


Lys Arg Ala Ser Pro Asp Arg Val Met Glu Val Ser Ala Ser Leu Cys 
    130                 135                 140                 


Lys Glu Glu Gln Lys Arg Arg Glu Gly Pro Arg Glu Gly Gln Trp Cys 
145                 150                 155                 160 


Cys Ser Trp Ser Phe Pro Arg Gly Arg Pro Thr Gly Thr Lys Phe Ser 
                165                 170                 175     


Val Lys Leu Phe Gly Tyr Glu Glu Ala Lys Arg Leu Ala Leu Tyr Thr 
            180                 185                 190         


Ala Leu Tyr Ala Tyr Ser Pro Glu Glu Arg Cys Asp Val Leu Gln Glu 
        195                 200                 205             


Leu Ile Asp Glu Val Leu Ala Thr Ala Ser Ser Ala Ser Leu Ser Ala 
    210                 215                 220                 


Ser His Leu Pro Asn Pro Glu Arg Phe Pro Ala Ile Leu Glu Leu Gln 
225                 230                 235                 240 


Pro Gln Pro Leu Ser Leu Ser Ser Ser Leu Ser Pro Ser Leu Cys Val 
                245                 250                 255     


Arg Leu Asp Ala Cys Ala Phe Pro Ser Pro Val Leu Ser Gly Ser Pro 
            260                 265                 270         


Leu Cys Ser Ser Pro Gly Leu Ser Ser Arg Gly Arg Asn Gly Ser Lys 
        275                 280                 285             


Ala Ala Arg Glu Thr Leu Ser Ile Asp Arg Gly Ile Arg Leu Ser Ser 
    290                 295                 300                 


Gln Ser Ser Ala Ser Ser Asn Ala Met Pro Ser Gln Phe Pro Gln Arg 
305                 310                 315                 320 


Trp Gln Ala Thr Glu Val Arg Met Ser Leu Leu Cys Arg Ser Ser Phe 
                325                 330                 335     


Arg Ala Ser Arg Arg Arg Glu Gly Gly Asn His Gly Glu Ala Glu Ala 
            340                 345                 350         


Glu Ala Lys Arg Ala Gly Gln Thr Arg Glu Lys Thr Gly Arg Arg Asp 
        355                 360                 365             


Lys Gly Asn His Pro His Asp Leu Ser Val Asn Asn Arg Lys Glu Pro 
    370                 375                 380                 


Asn Lys Leu Glu Lys Ser His Ser Ser Cys Ser Pro Arg Arg Ser Leu 
385                 390                 395                 400 


Phe Ser Ser Ile Gln Val Gln Gln Asp Glu Arg Ser Gly Gly Arg Leu 
                405                 410                 415     


Leu His Gly Phe Arg Gly Asp Met Glu Glu Gly Lys Arg Ala Ser Arg 
            420                 425                 430         


Ala Asn Lys His Val Glu Ala Lys Lys Gly Glu Val Thr Gly Arg Arg 
        435                 440                 445             


Lys Gly Val Cys Gly Gly Ala Leu Phe Gly Cys Phe Pro Ala Arg Arg 
    450                 455                 460                 


Gly Arg Glu Arg Gly Glu Asp Glu Gly Glu Arg Glu Lys Ala Gly Gln 
465                 470                 475                 480 


Val Asn Ala Gln His 
                485 


<210>  19
<211>  3837
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Phe Ala Pro Arg Thr Ser Pro Arg Leu Ser Ala Gly Ala Gly 
1               5                   10                  15      


Gly Pro Ser Glu Ala Ser Arg Gly Gly Thr Ala Ala Gly Ala Pro Leu 
            20                  25                  30          


Gly Pro Val Glu Thr Pro Thr Gly Arg Glu Pro Ser Ser Pro Phe Leu 
        35                  40                  45              


Arg Ser Ala Ser Ala Lys Arg Val Thr Arg Ala Arg Ala Gly Phe Leu 
    50                  55                  60                  


Ala Ser Ser Pro Asp Asn Gln Ser Arg Ser Thr Ser Pro Leu Arg Pro 
65                  70                  75                  80  


Ala Asp Ala Leu Arg Ile Ser Glu Ala Ser Ser Ala Ser Ala Pro Gly 
                85                  90                  95      


Val Arg Arg Ser Leu Arg Ala Ser Asn Ala Arg Pro Pro Val Ser Ala 
            100                 105                 110         


Ser Arg Gly Leu Met Gly Lys Ala Gly Glu Glu Gly Glu Gly Ala Ser 
        115                 120                 125             


Gly Gly Gly Arg Pro Gly Gly Ala Arg Arg Thr Ser Gly Gly Gly Glu 
    130                 135                 140                 


Asp Val Cys Ala Ser Pro Arg Asp Ile Ser Tyr Arg Asp Lys Gly Ala 
145                 150                 155                 160 


Gly Gly Asp Ala Thr Ala Ser Ser Asn Ser Gln Ser Pro Ser Ser Val 
                165                 170                 175     


Asp Ala Ala Val Ser Ser Ser Tyr Ser Val Ala Ser Ser Val Ser Ser 
            180                 185                 190         


Pro Pro Ala Ser Ser Leu Ser Ser Ala Leu Ser Ser Ser Phe Ser Ser 
        195                 200                 205             


Ser Thr Leu Ser Arg Ser Gly Ser Ser Val Cys Pro Arg Ala Thr Ser 
    210                 215                 220                 


Ala Val Ser Ala Thr Leu Gln Gln Gly Glu Arg Ser Gln Glu Ser Ser 
225                 230                 235                 240 


Leu Leu Ala Gly Glu Arg Glu Thr Asp Arg Asp Ala Asn Arg Pro Gln 
                245                 250                 255     


Arg Glu Thr Asp Glu Gly Gln Gly Ala Lys Ser Glu Thr Asp Arg Ala 
            260                 265                 270         


Pro Glu Asp Asp Arg Gly Arg Ser Arg Arg Gly Ser Ala Ser Pro Val 
        275                 280                 285             


Gln Gly Pro Phe Ser Pro Arg Gly Phe Phe Ser Asn Ala Val Thr Lys 
    290                 295                 300                 


Glu Asn Ser Ala Tyr Pro Ala Thr Ser Gly Gln Ser Gly Gln Glu Val 
305                 310                 315                 320 


Gly Cys Arg Pro Asn Ser Thr Leu Ser Ser Val Ser Val Cys Ser Leu 
                325                 330                 335     


Ser Ser Arg Pro Pro Ser Thr Leu Ala Ser Asp Gln Leu Leu Ser Val 
            340                 345                 350         


Pro Asn Gly Asp Ala Ser Thr Val Ser Thr Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Cys Ser Cys Ser Ser Phe Ser Ser Ser Ser Ser Ser Leu Ser Ser Ser 
    370                 375                 380                 


Ser Leu Leu Ser Ser Ser Pro Leu Ser Ser Thr Pro Ser Ser Phe Phe 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser Val Ala Pro Pro Gly 
                405                 410                 415     


Glu Gly Lys Gly Arg Pro Pro Val Arg Ser Gly Arg Gly Ala Cys Pro 
            420                 425                 430         


Arg Lys Pro Ala Gly Pro Pro Pro Arg Leu Cys Val Pro Tyr Gln Cys 
        435                 440                 445             


Gln Phe Asn Val Glu Lys Arg Glu Trp Arg Ala Arg Tyr Leu Phe Arg 
    450                 455                 460                 


Gly Gln Lys Lys Met Arg Val Phe Ser Leu Ala Arg Tyr Ser Pro Glu 
465                 470                 475                 480 


Val Ala Val Ser Leu Ala Glu Leu Phe Leu Thr Phe Leu Ala Asp Asn 
                485                 490                 495     


Asp Gly Ile Pro Arg Ser Glu Val Ile Ala Tyr Trp Ala Glu Thr Leu 
            500                 505                 510         


Ala Arg Gly Pro Val Thr Ala Thr Thr Gly Thr Asn Pro Lys Gly Gly 
        515                 520                 525             


Asn Leu Leu Gly Pro Gly Ala Ser Glu Glu Glu Thr Val Gly Gly Glu 
    530                 535                 540                 


Gly Gly Glu Asp Ala Glu Ser Arg Ala Ala Glu Lys Glu Arg Glu Glu 
545                 550                 555                 560 


Glu Gly Lys Ala Ser Ser Ser Ser Gly Ser Ser Asp Gln Asn Ile Thr 
                565                 570                 575     


Arg Val Glu Ser Ser Glu Ala Lys Glu Asp Gly Glu Glu Asn Ser Ala 
            580                 585                 590         


Ser Ser Lys Pro Pro Gly Ala Ala Ser Ala Ala Thr Glu Pro Ala Gly 
        595                 600                 605             


Gly Asp Ala Asp Gly Arg Pro Gly Arg Ala Ala Ser Gly Pro Gly Asp 
    610                 615                 620                 


Ala Cys Arg Ser Val Thr Ser Thr Glu Thr Glu Ala Ala Val Ala Val 
625                 630                 635                 640 


Ala Pro Glu Ala Lys Gly Gly Pro Ser Ser Asp Val Ser Cys Thr Leu 
                645                 650                 655     


Asp Lys Ser Arg Glu Ser Arg Gly Asn Gly Val Ala Gly Lys Arg Glu 
            660                 665                 670         


Asn Pro Ala Trp Ala Val Ser Pro Ser Ser Phe Ala Ala Phe Val Glu 
        675                 680                 685             


Thr Ala Lys Ala Arg Gln Trp Val Thr Glu Ala Ser Arg Leu Gln Ala 
    690                 695                 700                 


Ala Ser Leu Pro Pro Leu Ala Pro Ala Glu Arg Pro Ala Arg Pro Pro 
705                 710                 715                 720 


Ile Leu Pro Thr Leu Ala Ser Ser Arg Ala Arg Arg Cys Thr Ser His 
                725                 730                 735     


Ser Leu Ile Ser Gly Leu Ser Ala Arg Glu Gly Ser Gln Arg Thr Val 
            740                 745                 750         


Ser Gln Gly Asp Ser Leu Ser Pro Ala Ser Gly Leu Ala Gly Glu Pro 
        755                 760                 765             


Gly Ala Val Arg Glu Ala Glu Gly Arg Glu Ala Ile Ala Val Asp Asp 
    770                 775                 780                 


Glu Thr Gly Gly Glu His Arg Asp Phe Pro His Ser Gln Gly Pro Ala 
785                 790                 795                 800 


Gly Arg Gly Arg Leu Ala Gly Ala Arg Pro Ser Ser Ser Asp Met Arg 
                805                 810                 815     


Gly Glu Lys Arg Gly Arg Arg Ala Leu Arg Glu Gly Glu Ser Lys Arg 
            820                 825                 830         


Pro Cys Arg Arg Arg Glu Asp Leu Lys Ser Glu Glu Gly Gln Arg Glu 
        835                 840                 845             


Arg Arg Arg Arg Asp Thr Ala Trp Pro Ala Gly Arg Arg Glu Ala Ser 
    850                 855                 860                 


His Gly Arg Gln Asp Ser Arg Val Lys Glu Glu Thr Pro Ala Pro Asp 
865                 870                 875                 880 


Ala Gly Ala Ala Leu Ala Leu Asp Gly Arg Ala Ala Ala Ala Arg Asp 
                885                 890                 895     


Arg Pro Gln Lys Ala Pro Ser Pro Phe Gly Thr Pro Glu Ala Leu Ser 
            900                 905                 910         


Ser Ser Leu Thr Gly Ser Gly Leu His Pro Asp Gly Arg Asn Pro His 
        915                 920                 925             


Gly His Pro Ala Leu Arg Val Lys Leu Ala Ala Gly Arg Gly Asn Gly 
    930                 935                 940                 


Leu Leu Ala Ala Ser Pro Ala Ser Pro Ser Ser Ala Ser His Ala Ser 
945                 950                 955                 960 


Ser Leu Ala Ser Pro Ser Ala Ser Trp His Ala Ala Gln Gly Glu Ala 
                965                 970                 975     


Glu Ile Pro Gly Ala Ser Thr Gly Phe Val Asp Ser Pro Cys Ser Ala 
            980                 985                 990         


Asn Gly Ser Leu Asp Asp Ser Gly  Leu Gly Gly Pro Ala  Ala Ala Leu 
        995                 1000                 1005             


Gln Lys  Ser Trp Arg Asp Arg  Lys Arg Asn Arg Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ser  Met His Arg Lys Ser  Leu Ala Ser Leu Gly  Met Arg Ala 
    1025                 1030                 1035             


Pro Pro  Gln Asn Ala Cys Leu  Ala Asp Pro Ser Asp  Val Gly Leu 
    1040                 1045                 1050             


Gly Val  Gln Met Pro Ser Asp  Ala Gly Thr Val Pro  Gly Ile Ser 
    1055                 1060                 1065             


Pro Pro  Ser Phe Gly Ala Ser  Glu Gln Lys Ala Ser  Ser Ser Ala 
    1070                 1075                 1080             


Leu Gly  Leu Ala Phe Arg Ala  Ser Ser Ser Phe Ser  Pro Lys Asn 
    1085                 1090                 1095             


Gly Asp  Val Glu Pro Ala Gly  Arg Asn Pro Pro Gln  Phe Leu Pro 
    1100                 1105                 1110             


Thr Ala  Ser Val Gln Arg Ala  Asp Pro Pro Gly Thr  Gly Ala Pro 
    1115                 1120                 1125             


Pro Ser  Gln Gln Val Val Ser  Ser Ala Ser Pro Cys  Ser Pro Ser 
    1130                 1135                 1140             


Ala Leu  Ala Ala Thr Ala Ser  Pro Gly Ala Cys Arg  Gly Gly Ala 
    1145                 1150                 1155             


Ser Arg  Asn Gly Asp Pro Gln  Gly Glu Arg Phe Ser  Phe Pro Ala 
    1160                 1165                 1170             


Ser Pro  Thr Ser Gln Tyr Arg  Trp Tyr Ala His Pro  Asp Gly Gly 
    1175                 1180                 1185             


Ala Thr  Gly Pro Ser Cys Cys  Arg Gln His Val Gly  Gly Ser Gly 
    1190                 1195                 1200             


Gly Gly  Gly Trp Pro Val Val  Trp Leu Lys Gln Leu  Glu Met Ala 
    1205                 1210                 1215             


Val Asn  Gly Pro Pro Lys Phe  Cys Ser Tyr Val Glu  Ala Val Asp 
    1220                 1225                 1230             


Lys His  Leu Arg Leu Gly Gly  Leu Arg Arg Pro Val  Ala Phe Leu 
    1235                 1240                 1245             


Pro Leu  Ala Ser Arg Pro Ala  Ser Pro Thr Gly Leu  Gly Gly Gly 
    1250                 1255                 1260             


Leu Gly  Ala Pro Gly Pro Ala  Leu Arg Gln Ala Ser  Glu Lys Ala 
    1265                 1270                 1275             


Leu Ala  Ala Glu Gly Arg Gln  Gly Gln Asn Glu Glu  Lys Gln Val 
    1280                 1285                 1290             


Gly Trp  Lys Ser Ala Thr Gly  Ser Lys Ala Gly Met  Phe Gln Gly 
    1295                 1300                 1305             


Asp Ser  Gly Glu Thr Thr Ser  Glu Arg Gly Ala Glu  Glu Ala Glu 
    1310                 1315                 1320             


Gly Thr  Gly Gly Gly Arg Arg  Gly Ile Leu Gly Lys  Glu Glu Glu 
    1325                 1330                 1335             


Asp Arg  Asn Gly Gly Glu Gly  Glu Lys Ala Ala Thr  Pro Thr Met 
    1340                 1345                 1350             


Gly Gly  Ala Ser Pro Ala Ala  Ser Asp Asp Ala Leu  Ser Pro Met 
    1355                 1360                 1365             


Lys Ala  Asp Arg Pro Ala Glu  Ala Leu Gly Thr Gly  Gly Ser Ala 
    1370                 1375                 1380             


Pro Thr  His Ala Asp Ser Arg  Arg Ala Pro Gly Met  Pro Glu Gly 
    1385                 1390                 1395             


Glu Lys  Met Thr Gly Pro Ser  Lys Glu Gln Glu Met  Ala Glu Ala 
    1400                 1405                 1410             


Gly Glu  Arg Asp Arg Cys Glu  Arg Ser Leu Glu Arg  Asn Ala Glu 
    1415                 1420                 1425             


Leu Val  Leu Lys Glu Asn Val  Ser Met Thr Ser Ala  Ser Asp Val 
    1430                 1435                 1440             


Ser Glu  Ala Ala Glu Glu Lys  Gly Ala Pro Lys Lys  Leu Ala Ser 
    1445                 1450                 1455             


Ser Pro  His Ser Val Glu Ser  Pro Cys Gly Arg Thr  Ala Glu Lys 
    1460                 1465                 1470             


Thr Gly  Thr Leu Asn Thr Ser  Glu Lys Gly Glu Asn  Thr Arg Thr 
    1475                 1480                 1485             


Ala Glu  Gly Asp Asp Pro Gly  Thr Thr Ile Val Lys  Glu Glu Phe 
    1490                 1495                 1500             


Pro Leu  Leu Pro Ala Pro Glu  Thr Pro Val Thr Val  Thr Ala Gln 
    1505                 1510                 1515             


Asp Leu  Leu Ser Pro Thr Val  Tyr Thr Pro Arg Trp  Gln Ala Thr 
    1520                 1525                 1530             


Val Gly  Lys Ser Leu Glu Leu  Gly Ser Leu Asn Cys  Glu Lys Ser 
    1535                 1540                 1545             


Cys Glu  Arg Gly His Trp Ala  Asp Ala Ser Ala Cys  Asp Leu Glu 
    1550                 1555                 1560             


Thr Lys  Asp Leu Arg Leu Pro  Glu Asp Asn Lys Ser  Glu Glu Leu 
    1565                 1570                 1575             


Lys Lys  Glu Thr Gly Met Phe  Leu Gly Val Glu Gly  Glu Gln Val 
    1580                 1585                 1590             


Glu Glu  Ala Lys Ser Ser Lys  Glu Ala Phe Ser Pro  Glu Glu Arg 
    1595                 1600                 1605             


Glu Arg  Glu Glu Gln Lys Glu  Ser Ser Lys Ala Ala  Gly Gly Gly 
    1610                 1615                 1620             


Asp Ser  Cys Arg Thr Pro Arg  Gln Gln Glu Ala Thr  Pro Arg Ala 
    1625                 1630                 1635             


Ser Glu  Glu Cys Gln Pro Glu  Ser Arg Ile Asp Met  Lys Val Ser 
    1640                 1645                 1650             


Pro Asn  Thr Glu Met Met Val  Glu Lys Leu Glu Glu  Thr Arg Val 
    1655                 1660                 1665             


Gln Asn  Thr Glu Glu Pro Glu  Lys Val Glu Glu Lys  Glu Glu Gly 
    1670                 1675                 1680             


Gly Ser  Val Cys Arg Asp Val  Ser Val Ala Ser Pro  Leu Glu Ser 
    1685                 1690                 1695             


Pro Asn  Ser Arg Leu Ser Glu  Lys Gly Asp Gln Ser  Glu Thr Pro 
    1700                 1705                 1710             


Ala Gly  Val Ala Pro Pro Ser  Ser Ser Ala Leu Glu  Ala Arg Ala 
    1715                 1720                 1725             


Gly Arg  Asp Ser Ala Leu Leu  Ser Ala Ser Leu Pro  Leu Ser Pro 
    1730                 1735                 1740             


Arg Ala  Ser Cys Pro Pro Thr  Gln Ser Ala Ser Pro  Ala Ser Arg 
    1745                 1750                 1755             


Asp Pro  Thr Pro Ala Ser Leu  Arg Val Ser Ser Val  Ala Ser Gly 
    1760                 1765                 1770             


Asp Arg  Asn Gly Pro Thr Gly  Ile Leu Phe Arg Pro  Leu Ser Ser 
    1775                 1780                 1785             


Pro His  Lys Arg Val Ser Phe  Cys Leu Arg Gly Gly  Ala Glu Pro 
    1790                 1795                 1800             


Pro Gln  Arg Pro Leu Ser Glu  Ala Val Pro Tyr Pro  Leu Asn Ala 
    1805                 1810                 1815             


Arg Leu  Gln Glu Ile Val Ser  Arg Phe Arg Leu Leu  Gln Gly Val 
    1820                 1825                 1830             


Ser Ala  Ala Arg Val Ser Ser  His Gly Lys Gly Glu  Thr Ser Ser 
    1835                 1840                 1845             


Gln Ala  Thr Pro Lys Ala Val  Gln Gly Glu Ala Thr  Val Lys Glu 
    1850                 1855                 1860             


Lys Ala  Thr Val Thr Pro Thr  Glu Ser Ala Lys Ser  Leu Ala Gly 
    1865                 1870                 1875             


Gly Gln  Ala Glu Thr Glu Lys  Gly Glu Ser Pro Ser  Gly Ala Glu 
    1880                 1885                 1890             


Ala Ala  Thr Gln Lys Ala Asp  Glu Lys Glu Lys Thr  Pro Asp Thr 
    1895                 1900                 1905             


Asp Ala  Thr Gln Ser Arg Ser  Thr Ser Ser Gly Phe  Glu Thr Gln 
    1910                 1915                 1920             


Glu Ala  Lys Thr Ala Pro Ala  Ser Ile Leu Pro Ala  Ser Ser Leu 
    1925                 1930                 1935             


Pro Ser  Ser Asp Arg Pro Ser  Ala Ser Cys Ser Asp  Thr His Ala 
    1940                 1945                 1950             


Ser Arg  Asp Ala Val Pro Leu  Ala Ser Ser Pro Ser  Ser Ser Ser 
    1955                 1960                 1965             


Ser Pro  Ala Leu Arg Arg Cys  Ser Val Arg Gly Lys  Asp Leu Val 
    1970                 1975                 1980             


Ser Ala  Pro Val Asp Ser Phe  Ser Glu Gly Asp Ser  Ser Asp Ala 
    1985                 1990                 1995             


Arg Pro  Phe Val Ser Val Arg  Asp Leu Ala Val Lys  Leu Tyr Arg 
    2000                 2005                 2010             


Trp Leu  Glu Gln Gly Glu Gly  Leu Pro Ala Ala Ala  Gly Glu Pro 
    2015                 2020                 2025             


Gln Gly  Ala Cys Gly Val Gly  Ala Lys Ala Gln Ala  Arg Glu Ala 
    2030                 2035                 2040             


Leu Arg  Ile Asp Thr Val Pro  Phe Ile Ser Arg Trp  Arg Gln Met 
    2045                 2050                 2055             


Leu Glu  Arg Ser Leu Ser Ile  Ala Ser Asp Leu Arg  Lys Leu Asp 
    2060                 2065                 2070             


Leu Gln  Val Val His Leu Val  Glu Leu Thr Glu Ala  Leu His Ile 
    2075                 2080                 2085             


Ala Val  Tyr Ile Cys Gly Gln  Leu Arg Arg Arg Leu  Arg Glu Gly 
    2090                 2095                 2100             


Ala Ala  Pro Asp Ala Gly Ala  Ala Glu Asp Leu Ala  Pro Val Asp 
    2105                 2110                 2115             


Val Asp  Asp Pro Arg Gly Cys  Ser Gln Gln Ser Gly  Asp Thr Arg 
    2120                 2125                 2130             


Asp Ser  Ser Ser Pro Ala Thr  Pro Gly Gly Arg Leu  Ala Gly Gly 
    2135                 2140                 2145             


Ala Gly  Gly Ala Ala Thr Ser  Pro Lys Gly Gln Ala  Phe Ala Pro 
    2150                 2155                 2160             


Arg Gly  Gly Glu Gly Glu Ile  Lys Pro Gln Glu Thr  Gly Asn Ser 
    2165                 2170                 2175             


Gly Asp  Ser Lys Ala Glu Gly  Lys Glu Ala Ser Gly  Asp Ala Asn 
    2180                 2185                 2190             


Thr Ser  Glu Gly Lys Arg Leu  Ser Gly Glu Val Asp  Lys Thr Ala 
    2195                 2200                 2205             


Glu Val  Glu Thr Ala Gly Ser  Glu Asp Ile Asn Val  Glu Arg Gly 
    2210                 2215                 2220             


Val Pro  Gly Ala Gln Ala Glu  Thr Ala Arg Thr Glu  Met Asn Gly 
    2225                 2230                 2235             


Gly Val  Val Lys Gly Gln Glu  Thr Ser Gly Asp Ile  Leu Ser Val 
    2240                 2245                 2250             


Gly Ser  Ser Gln Val Leu Ser  Leu Ser Ser Pro Ser  Leu Ser His 
    2255                 2260                 2265             


Leu Ala  Ser Ser Ser Gly Lys  Gly Pro Leu Lys Pro  Thr Ser Ser 
    2270                 2275                 2280             


Pro Ser  Ser Ser Leu Tyr Ala  Leu Ser Pro Ser Ser  Ser Ala Ala 
    2285                 2290                 2295             


Ser Pro  Phe Ser Ala Gln Leu  Ala Ser Pro Ser Ser  His Ala Pro 
    2300                 2305                 2310             


Leu Ser  Leu Ser Phe Arg Ser  Ser Ser Ser Pro Thr  Ser Leu Ser 
    2315                 2320                 2325             


Ser Pro  Leu Ala Ser Tyr Pro  Phe Pro Gln Thr Leu  Gln Gln Thr 
    2330                 2335                 2340             


Ser Ala  Ser Pro Ser Ser Ser  Ala Ser Ala Arg Pro  Ser Cys Ala 
    2345                 2350                 2355             


Ser Val  Lys Pro Leu Arg Glu  Ala Gly Asp Leu Val  Arg Ala Ala 
    2360                 2365                 2370             


Ala Arg  Ala Ala Leu Glu Gln  Ala Gln Val Phe Gly  Val Gly Gly 
    2375                 2380                 2385             


Lys Leu  Ser Asp Ala Thr His  Gln Leu Ala Ala Arg  Val Thr Val 
    2390                 2395                 2400             


Ala Val  Arg Ala Ala Met Leu  Ala Lys Gly Glu Gly  Gly Leu Thr 
    2405                 2410                 2415             


Arg Gly  Asp Val Asp Leu Leu  Val Glu Glu Thr Glu  Arg Phe Val 
    2420                 2425                 2430             


Arg Glu  Ala Arg Phe Lys Ala  Gln Glu Thr Ala Ala  Glu Thr Thr 
    2435                 2440                 2445             


Ala Leu  Pro Asp Gly Val Ala  Glu Val Val Ser Ser  Glu Ala Gly 
    2450                 2455                 2460             


Leu Gly  Leu Gln Thr Thr Asn  His Ala Pro Val Ser  Pro Ala Ala 
    2465                 2470                 2475             


Ala Pro  Ser Ala Gly Gly Ala  Phe Ala Gly Leu Thr  Glu Ala Val 
    2480                 2485                 2490             


Glu Val  Glu Ala Arg Gln Leu  Pro Glu Ala Ser Glu  Arg Val Gly 
    2495                 2500                 2505             


Arg Val  Ser Ser Pro Arg Gly  Ser Leu Gly Phe Glu  Ala Met Asp 
    2510                 2515                 2520             


Leu Ala  Gly Glu Leu His Leu  Val Lys Val Leu Asn  Ala Phe His 
    2525                 2530                 2535             


Arg His  Thr Glu Cys Leu Met  Asn Glu Arg Glu Arg  Leu Ile Gln 
    2540                 2545                 2550             


Ala Thr  Asn Glu Asp Leu Ser  Phe Leu Leu His Ala  Met Glu Leu 
    2555                 2560                 2565             


Ala Leu  Pro Ser Gly Leu Asp  Thr Pro Leu Leu Ser  Ile Leu Glu 
    2570                 2575                 2580             


Gly Asp  Val Asp Ile Leu Pro  Pro Leu Pro Pro Pro  Asn Val Glu 
    2585                 2590                 2595             


Ala Leu  Ile Tyr Leu His Ala  Val Ser Leu Ala Gln  Ala Asp Ala 
    2600                 2605                 2610             


Ser Ala  Ser Pro Ser Ser Pro  Ser Ala Val Ala Pro  Cys Leu Leu 
    2615                 2620                 2625             


Ser Pro  Ser Ala Arg Leu Leu  Leu Ala His Phe Ala  Gly Ala Ser 
    2630                 2635                 2640             


Pro Thr  Ala Gly Gly Leu Gly  Gly Asp Ser Ala Lys  Gly Arg Thr 
    2645                 2650                 2655             


Met Ser  Ser Phe Pro Gly Arg  Pro Gly Glu Glu Arg  His Arg Ala 
    2660                 2665                 2670             


Asp Glu  Arg Lys Gly Ser Val  Leu Pro Val Arg Arg  Gly Arg Pro 
    2675                 2680                 2685             


Pro Ser  Ser Ala Arg Leu Asn  Ala Leu Arg Arg Leu  His Ala Val 
    2690                 2695                 2700             


Gly Glu  Pro Ala Ala Asp Ala  Gly Leu Asp Thr Val  Asn Gly Arg 
    2705                 2710                 2715             


Phe Arg  Ser Lys Arg Leu Arg  Ala Met Ser Gln Glu  Glu Glu Ala 
    2720                 2725                 2730             


Arg Arg  Ala Ala Thr His Ala  Ser Pro Thr Ile Pro  Tyr Pro Leu 
    2735                 2740                 2745             


Ser Arg  Tyr Leu His Arg Pro  Pro Arg Leu Leu Ser  Pro Thr Asp 
    2750                 2755                 2760             


Ala Gly  His Phe Ala Ser Ser  Tyr Ser Ser Pro Leu  Ser His Pro 
    2765                 2770                 2775             


Leu Ser  Lys Gly Ser Ser Leu  Thr Ser Pro Lys Arg  Gln Arg Arg 
    2780                 2785                 2790             


Ser Val  Cys Ser Glu Ala Pro  Glu His Glu Arg Lys  Asn Leu Arg 
    2795                 2800                 2805             


Ser Leu  Phe Lys Ser Pro Ser  Ala Gln Arg Glu Glu  Ala Pro Arg 
    2810                 2815                 2820             


Ser Leu  Thr Arg Pro Phe Gly  Pro Leu Lys Gly Glu  Gly Phe Ser 
    2825                 2830                 2835             


Pro Ala  Ser Leu Gly Thr Leu  Gly Ser Arg Arg Gln  Ser Glu Leu 
    2840                 2845                 2850             


Gly Ile  Arg Arg Arg Asp Ala  Leu Val Ala Phe Pro  Pro Ala Gly 
    2855                 2860                 2865             


Met Pro  Cys His Pro Ala Ser  Pro Gly Arg Arg Leu  Glu Arg Pro 
    2870                 2875                 2880             


Arg Val  Asp Gly Ala Asp Met  Asp Gly Glu Arg Arg  Arg Arg Thr 
    2885                 2890                 2895             


Arg Cys  Ala Gly Asp Arg Leu  Glu Glu Arg Arg Arg  Pro Leu Gly 
    2900                 2905                 2910             


Pro Val  Tyr Ile Pro Thr Lys  Val Arg Asp Pro Ala  Thr Gly Arg 
    2915                 2920                 2925             


Val Ala  Val Cys Ala Cys Asp  Thr Glu Arg Gly Glu  Arg Val Arg 
    2930                 2935                 2940             


Lys Val  Gln Leu Phe Glu Lys  Pro His Val Gly Ala  Phe Trp Cys 
    2945                 2950                 2955             


Ala Arg  Tyr Gly Pro Asn Asp  Glu Phe Val Arg Cys  Phe Ser Ile 
    2960                 2965                 2970             


Glu Lys  Val Gly Ser Leu Lys  Ala Leu Val Ser Ala  Val Arg Phe 
    2975                 2980                 2985             


Arg Gln  Tyr Val Thr Gly His  Ser Leu Gly Tyr Gly  Val Gly Asn 
    2990                 2995                 3000             


Cys Val  Pro Val Glu Thr Ile  Arg Ser Ala Gly Arg  Arg Asp Arg 
    3005                 3010                 3015             


Asn Gly  Asp Val Ala Pro Asp  Arg Pro Leu Lys Gln  Ala Ala Ala 
    3020                 3025                 3030             


Ser Pro  Pro Pro Ala Gly Val  Ala Gly Ala Leu Gly  Arg Gly Glu 
    3035                 3040                 3045             


Val Gly  Gln Ala Gln Asp Glu  Ser Gly Glu Thr Arg  Asp Ala Val 
    3050                 3055                 3060             


Glu Glu  Glu Gly Arg Gly Gln  Glu Pro Leu Gly Ser  Gly Glu Gly 
    3065                 3070                 3075             


Ala Ser  Gly Val Ala Ala Lys  Glu Gly His Gly Ser  Ser Arg Gly 
    3080                 3085                 3090             


Glu Gly  Glu Gly Ala Glu Gly  Arg Thr Asp Ser Ala  Ala Gly Ser 
    3095                 3100                 3105             


Thr Ala  Gly Asp Arg Ser Thr  Glu Asp Ser Ser Arg  Leu Leu Ser 
    3110                 3115                 3120             


Glu Gly  Arg Asp Ala Lys His  Gly Ser Ser Pro Ala  Gly Gly Ser 
    3125                 3130                 3135             


Glu Ala  Leu Ala Pro Gly Gly  Glu His Ala Leu Ala  Glu Gly Ser 
    3140                 3145                 3150             


Glu Lys  Val Gly Arg Ala Gln  Glu Thr Glu Ala Arg  Lys Glu Asp 
    3155                 3160                 3165             


Leu Arg  Thr Ser Gln Asn Glu  Thr His Ser Gly Glu  Asp Val Ser 
    3170                 3175                 3180             


Ser Leu  Asn Glu Lys Ala Leu  Asp Ser Pro Arg Ser  Ser Ala Pro 
    3185                 3190                 3195             


Gln Gly  Lys Ser Asp Gln Gly  Arg Glu Pro Ile Ala  Leu Arg Ile 
    3200                 3205                 3210             


Arg Ser  Thr Leu Pro Pro Ser  Glu Val Asp Lys Gln  Glu Ala Ala 
    3215                 3220                 3225             


Gly Gln  Gly Gly Ser Ala Ser  Glu Leu Ala Phe Pro  Thr Gly Val 
    3230                 3235                 3240             


Ser Leu  Ala Ser Pro Val Ser  Pro Phe Ser Ala Leu  Ala Arg Ser 
    3245                 3250                 3255             


Pro Ile  Ser Ala Arg Ala Ser  Ser Val Ser Pro Gly  Ala Cys Asp 
    3260                 3265                 3270             


Arg Pro  Asp Val Ser Arg Arg  His Ser Gly Ser Ser  Asp Glu Ala 
    3275                 3280                 3285             


Ser Glu  Ala Leu Trp Asp Leu  Gly Glu Asp Leu Gly  Phe Ala Gly 
    3290                 3295                 3300             


Asp Asp  Ala Asn Phe Pro Phe  Leu Asp Ser Glu Asn  Ser Ala Leu 
    3305                 3310                 3315             


Leu Phe  Ala Pro Pro Arg His  Leu Met Ser Pro Gly  Ser Ala Ser 
    3320                 3325                 3330             


Pro Thr  Gly Gly Gly Leu Gly  Ile His Tyr Asp Lys  Thr Lys His 
    3335                 3340                 3345             


Arg Trp  Lys Ala Thr Trp Thr  Thr Leu Asp Gly Gln  Arg Ala Ser 
    3350                 3355                 3360             


Thr Ser  Phe Ser Val Lys Val  Leu Gly Met Glu Arg  Ala Arg Glu 
    3365                 3370                 3375             


Leu Ala  Leu Glu Ala Arg Gln  Arg Ala Leu Ala Gly  Leu Asp Pro 
    3380                 3385                 3390             


Arg Glu  Val Arg Asp Glu Met  Val Ala Gly Gly Ala  Ala Ala Arg 
    3395                 3400                 3405             


Asp Arg  Glu Arg Glu Arg Gly  Arg Gln Asp Gly Arg  Arg Glu Gly 
    3410                 3415                 3420             


Ser Glu  Arg Arg Val Gly Phe  Glu Ala Glu Ala Glu  Gly Thr Glu 
    3425                 3430                 3435             


Ala Ala  Ser Glu Arg Leu Arg  Arg Arg Gly Glu Arg  Glu Asp Gly 
    3440                 3445                 3450             


Asp Glu  Glu Arg Arg Arg Lys  Lys Thr Arg Gly Asp  Glu Leu Arg 
    3455                 3460                 3465             


Gly Ala  Glu Gly Asp Arg Glu  Glu Arg Glu Leu Arg  Arg Arg Lys 
    3470                 3475                 3480             


Thr Ser  Glu Glu Arg Arg Lys  Gly Lys Asn Glu Ala  Ala Lys Asn 
    3485                 3490                 3495             


Glu Ala  Ala Lys Asn Glu Ala  Ala Lys Asn Glu Gly  Gly Lys Gly 
    3500                 3505                 3510             


Glu Thr  Trp Lys Val Arg Glu  Gly Gly Lys Thr Pro  Leu Gly Val 
    3515                 3520                 3525             


Lys Ser  His Arg Ala Lys Val  Val Gly Gln Thr Val  Glu Arg Arg 
    3530                 3535                 3540             


Gly Glu  Glu Arg Arg Arg Asp  Leu Arg Gly Ser Arg  Arg Glu Glu 
    3545                 3550                 3555             


Gly Lys  Thr Val Trp Gly Gln  Glu Gln Asp Ala Glu  His Gln Val 
    3560                 3565                 3570             


Phe Glu  Gly Val Lys Glu Asp  Asp Asn Glu Arg Gly  Arg Arg Arg 
    3575                 3580                 3585             


Glu Arg  Arg Arg Phe Glu Glu  Arg Asp Ser Leu Arg  Gly Ser His 
    3590                 3595                 3600             


Gly Ala  Thr Pro Ser Asp Glu  Gln Arg Gln Met Arg  Arg Gln Thr 
    3605                 3610                 3615             


Ile Leu  Gly Ser Arg Glu Val  Asp Gly Lys Pro Leu  Ser Phe Asp 
    3620                 3625                 3630             


Asp Thr  His Arg Val Asp Ala  Gln Leu Gly Ile Gln  Asn Glu Val 
    3635                 3640                 3645             


Ala Phe  Pro Gly Pro Gln Gly  Val Gly Gly Ala Gly  Asn Ser Leu 
    3650                 3655                 3660             


Gln Phe  Gly Arg Glu Gly Glu  Arg Phe Ala Ser Ser  Ser Pro Val 
    3665                 3670                 3675             


Ala Phe  Leu Arg Thr Lys Glu  Glu Asp Glu Glu Ile  Val Glu Val 
    3680                 3685                 3690             


Phe Leu  Thr Pro Glu Gly Ser  Gly Ser Glu Arg Asp  Lys Ala Ser 
    3695                 3700                 3705             


Ser Val  Ser Ala Ser Ser Ala  Pro Arg Asp Ser Arg  Pro Ala Ser 
    3710                 3715                 3720             


Pro Arg  Leu Arg Ala Ser Arg  Leu Arg Glu Ser Ala  Arg Leu Gln 
    3725                 3730                 3735             


Arg Arg  Leu Glu Glu Ala Glu  Val His Asp Arg Gly  Ser Arg Pro 
    3740                 3745                 3750             


Leu Arg  Pro Glu Glu Arg Arg  Val Ala Lys Arg His  Val Ala Glu 
    3755                 3760                 3765             


Glu Asn  Val Asp Ala Thr Phe  Ser Ala Gly Ala Gly  Gly Thr Lys 
    3770                 3775                 3780             


Lys Ile  Arg Pro His Ser Ser  His Asp Phe Ser Ala  Glu Gly Leu 
    3785                 3790                 3795             


Ser Lys  Phe Gln Glu Leu Leu  Thr Trp Asp Cys Glu  Val Glu Ile 
    3800                 3805                 3810             


Asp Gly  Thr Asp Ala His Val  Trp Arg Ala Val Ala  Ala Leu Pro 
    3815                 3820                 3825             


Gly Pro  Arg Pro Arg Pro Arg  Tyr Val 
    3830                 3835         


<210>  20
<211>  1292
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Cys Gln Glu Arg Lys Pro Arg Glu Leu Ser Leu Arg Asn Asn Ser 
1               5                   10                  15      


Arg Ala Arg Glu Arg Arg Gly Ser Lys Leu Glu Pro Gly Val Ser Cys 
            20                  25                  30          


Leu Ser Leu Ser Ala Cys Pro Ser Val Ala Pro Asn Asp Arg Gly Gly 
        35                  40                  45              


Val Thr Thr Pro Arg Ser Leu His Ala Trp Thr Arg Glu Val Ser Ala 
    50                  55                  60                  


Cys Arg Leu Pro Arg Gln Gln Val Ser Arg Pro Leu Pro Arg Arg Ser 
65                  70                  75                  80  


Leu Ser Arg Pro Arg Ser Glu Pro Asp Ala Ser Pro Val Lys Gly Pro 
                85                  90                  95      


Gly Gln Arg Val Glu Ala Ser Ala Val Glu Gly Gly Pro Ser Ala Ser 
            100                 105                 110         


Ser Ala Glu Arg Leu Gln Val Asp Asp Gly Leu Ala Ala Met Arg Lys 
        115                 120                 125             


Thr Lys Lys Gly Lys Gly Glu Glu Gly Gly Glu Glu Thr Glu Arg Trp 
    130                 135                 140                 


Ala Thr Gln Ala Val Glu Gln Gln Gly Thr Leu Lys Pro Ala Gly Glu 
145                 150                 155                 160 


Glu Thr Ala Val Pro Gly Ala Ser Glu Arg Ser Ala Ser Pro Gln Gln 
                165                 170                 175     


Ala Met Glu Gly Ser Cys Gly Val Glu Thr Pro Glu Thr Phe Phe Gly 
            180                 185                 190         


Val Ser Thr Gly Asn Ser Gln Gly Ser Pro Ser Pro Glu Ser Val Ala 
        195                 200                 205             


Gly Glu Glu Ala Arg Pro Glu Arg Glu Asn Ala Glu Lys Ser Ala Thr 
    210                 215                 220                 


Gly Gly Ser Ala Ser Lys Ala Lys Lys Pro Ser Arg Glu Ser Ala Arg 
225                 230                 235                 240 


Arg Pro Asp Thr Ala Leu Ile Asp Arg His Leu Ile Ala Ala Ser Pro 
                245                 250                 255     


Ser Pro Ser Ser Ala Arg Arg Ser Ser Thr Cys Ser Pro Ser Pro His 
            260                 265                 270         


Ser Arg Glu Gly Glu Asp Lys Pro Gly Ser Gly Ala Pro Pro Ala Ser 
        275                 280                 285             


Ser Pro Ser Ala Asn Ala Gly Ala Leu Glu Pro Ala Glu Lys Gly Thr 
    290                 295                 300                 


Leu Gly Ser Pro Pro Gln Asp Val Leu Pro Ala Leu Pro Ala Ser Ser 
305                 310                 315                 320 


Ser Ser Pro Ser Thr Gly Gly Gly Ser Pro Leu Ser Pro Pro Pro Gly 
                325                 330                 335     


Gln Ala Pro Arg Ala Glu Ser Gly Ala Pro Gly Ser Gly Ala Leu Ser 
            340                 345                 350         


Leu Arg Arg Ser Leu Arg His Arg Gln Pro Val Arg Pro Ala Ala Ile 
        355                 360                 365             


Ala Val Ser Pro Leu Gly Gly Pro Gly Ser Ser Leu Ser Ser Arg Ser 
    370                 375                 380                 


Ala Ser Pro Thr Arg Arg Gly Gly Val Ser Pro Cys Gly Pro Ala Thr 
385                 390                 395                 400 


Ala Val Gly Lys Gly Ala Gly Ala Ala Ser Gly Ala Ala Ala Leu Pro 
                405                 410                 415     


Gly Val Gly Ala Lys Ala Pro Pro Ser Ala Thr Pro Leu Ala Gly Leu 
            420                 425                 430         


Ser Gly Arg Ser Leu Leu Ala Ser Val Ser Pro Ser Ala Ala Ala Leu 
        435                 440                 445             


Gly Pro Gly Ala Pro Gly Lys Lys Lys Ala Gly Gln Val Gln Gly Ala 
    450                 455                 460                 


Ala Lys Ala Arg Gly Ala Pro Pro Phe Val Leu Ala Glu Tyr Trp Pro 
465                 470                 475                 480 


Gly Val Thr Leu Asp Glu Met Glu Lys Gly Glu Leu Ser Trp Ala Arg 
                485                 490                 495     


Ala Ala Ala Gly Leu Pro Leu Pro Ala Ser Pro His Lys Val Pro Gly 
            500                 505                 510         


Gly Pro Ala Pro Pro Val Gly Gly Pro Pro Ala Arg Asp Glu Asp Ser 
        515                 520                 525             


Val Ala Ala Cys Ala Gly Glu Lys Gly Lys Glu Lys Ala Phe Leu Gly 
    530                 535                 540                 


Ser Gly Arg Ser Gln Ala Ala Gln Gly Leu Pro Gly Ile Asp Ala Val 
545                 550                 555                 560 


Ala Ala Ala Cys Trp Gly Gly Ala Gly Val Asp Ser Arg Val Leu Ala 
                565                 570                 575     


Pro Ala Glu Gly Glu Ala Ser Gly Ala Phe Gly Pro Gly Gly Glu Lys 
            580                 585                 590         


Lys Lys Val His Ala Ser Ser Asp Ser Ser Gly Gly Ser Arg Ala Ala 
        595                 600                 605             


Leu Gly Gly Arg Ala Ser Val Gln Gly Lys Ala Arg Lys Pro Ala Gly 
    610                 615                 620                 


Trp Glu Glu Glu Arg Gly Arg Arg Asp Asp Arg Ser Arg Gly Arg Arg 
625                 630                 635                 640 


Asp Glu Thr Asp Gly Pro Arg Phe Asp Val Thr Trp Phe Val Asp Asp 
                645                 650                 655     


Ser Pro Leu Ala His Thr Arg Lys Arg Thr Arg Trp Asp Ser Leu Trp 
            660                 665                 670         


Val Arg Pro Ala Ser Pro Val Arg Val Val Gly Asp Ser Ala Pro Glu 
        675                 680                 685             


Glu Ser Pro Glu Arg Arg Glu Gly Gly Gly Arg Ala Pro Asp Leu Gln 
    690                 695                 700                 


Ala Ser Met Ala Lys Arg Arg Thr Ala Asp Ser Gly Leu Glu Glu Glu 
705                 710                 715                 720 


Ala Gln Val Glu Arg Gly Phe Ser Ser Ser Asp Ser Asp Asp Cys Asp 
                725                 730                 735     


Trp His Leu Pro Thr Arg Thr Val Ser Ser Ser Leu Ala Pro Phe Ala 
            740                 745                 750         


Ala Ser Lys Ala His Leu Val Pro Arg Cys Cys Tyr Cys Leu Leu Pro 
        755                 760                 765             


Arg Arg Leu Pro Gly Arg His Thr Glu Ala Gly Gly Pro Pro Arg Asp 
    770                 775                 780                 


Leu Leu Gly Trp Ser Thr Ser Val Glu Ser Glu Glu Thr Arg Gly Arg 
785                 790                 795                 800 


Tyr Leu Gln Leu Tyr Cys Ala Cys Thr Lys Arg Pro Phe Gly Glu Ser 
                805                 810                 815     


Val Leu Gln Gly Ala Ala Gly Arg Arg Gly Leu Leu Leu Pro Val Ala 
            820                 825                 830         


Thr Asn Ala Leu Leu Tyr Ser Val Arg Arg Val Ala Leu Asp Gly Ala 
        835                 840                 845             


Ala Ser Glu Gln Lys Ser Glu Ala Leu Pro Thr Ser Ala Val Ser Arg 
    850                 855                 860                 


Pro Ser Ser Ala Val Arg Ala Arg Ser Ser Cys Ala Ser Ser Gly Cys 
865                 870                 875                 880 


Asp Asp Gly Arg Ala Glu Val Ala Pro Gly Ala Pro Ala Glu Thr Ile 
                885                 890                 895     


Tyr Arg Trp Arg Asp Pro Cys Thr Leu Gln Thr Phe Ser Ser Ser Leu 
            900                 905                 910         


Asp Arg Ile Gln Gly Ser Leu Ala Ala Thr Ala Ala Val Ala Ala Ala 
        915                 920                 925             


Ala Glu Ser Ala Gly Lys Pro Val Ala Phe Leu Pro Arg Leu Tyr Trp 
    930                 935                 940                 


Asp Ser Gln Ala Asp Cys Tyr Ile Ala Ser Cys Leu Arg Trp Glu Glu 
945                 950                 955                 960 


Glu Ala Gln Pro Thr Pro Ala Ala Glu Arg Gly Glu Lys Arg Asn Gly 
                965                 970                 975     


Val Glu Arg Pro Ala Glu Ala Arg Glu Arg Gly Arg Asp Glu Lys Lys 
            980                 985                 990         


Pro Glu Asp Pro Ser Val Pro Gly  Leu Arg Arg Arg Ser  Leu Lys Leu 
        995                 1000                 1005             


Leu Gln  Lys Lys Phe Ser Val  Ala Phe Leu Gly Asp  Ala Lys Ala 
    1010                 1015                 1020             


His Phe  Tyr Ala Ser Glu Trp  Leu Lys Trp Gln His  Lys Gly Gln 
    1025                 1030                 1035             


Arg Met  Met Asp Glu Glu Asp  Arg Arg Gln Glu Val  Ala Arg Gln 
    1040                 1045                 1050             


Met Leu  Leu Val Ser Pro Leu  Leu Ala Gly Arg Lys  Ala Pro Ala 
    1055                 1060                 1065             


Lys Ala  Pro Gly Gly Cys Ser  Lys Lys Ala Ser Ser  Leu Ser Ala 
    1070                 1075                 1080             


Ala Gln  Leu Ala Leu Ala Ser  Gly Arg Pro Leu Thr  Pro Glu Glu 
    1085                 1090                 1095             


Glu Ala  Glu Leu Lys Arg Gln  Leu Glu Asn Lys Glu  Arg Gln Lys 
    1100                 1105                 1110             


Lys Gln  Lys Leu Leu Arg Gln  Gln Trp Arg Arg Gln  Gln Ala Arg 
    1115                 1120                 1125             


Glu Ala  Lys Leu Arg Leu Arg  Glu Ala Glu Ala Ala  Ala Ala Ala 
    1130                 1135                 1140             


Ala Ala  Ala Ala Gly Ala Pro  Ser Ala Pro Gly Thr  Thr Gly Ala 
    1145                 1150                 1155             


Ser Gln  Thr Arg Ser Pro Gln  Ser Gln Gln Lys Ser  Glu Ser Leu 
    1160                 1165                 1170             


Pro Val  Leu Arg Ser Lys Thr  Glu Val Leu Gln Pro  Ser Pro Gly 
    1175                 1180                 1185             


Ala Ser  Phe Ala Pro Ala Ser  Ser Arg Ser Thr Leu  Pro Ala Gly 
    1190                 1195                 1200             


Glu Ser  Gly Ala Ala Pro Cys  Glu Gly Val Gly Thr  Arg Arg Ser 
    1205                 1210                 1215             


Ala Ala  Ser Ala Thr Ser Val  Ala Pro Glu Lys Val  Thr Gly Arg 
    1220                 1225                 1230             


Lys Ser  Glu Thr Ala Arg Asp  Ala Ala Ser Ala Ser  Leu Glu Ala 
    1235                 1240                 1245             


Ala Lys  Ser Thr Met Val Thr  Arg Gly Gly Gly Arg  Gly Ser Ser 
    1250                 1255                 1260             


Val Val  Ala Val Thr Arg Ser  Thr Ser Ser Pro Ser  Gly Arg Ala 
    1265                 1270                 1275             


Ala Ser  Val Ala Ser Ser Thr  Leu Gly Gly Phe Gly  Ala Arg 
    1280                 1285                 1290         


<210>  21
<211>  2406
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Pro Ala Pro Ser Ala Glu Ala Arg Pro Ala Lys Arg Arg 
1               5                   10                  15      


Cys Phe Pro Leu Pro Arg Glu Thr Pro Val Ser Ser Glu Asp Glu Thr 
            20                  25                  30          


Arg Lys Thr Leu Gln His Asp Thr Leu Gly Cys Leu Pro Arg Ser Ser 
        35                  40                  45              


Ser Gly Gln Pro Glu Leu Ala Ala Ala Ser Ala Ala Ser Gln Val Gly 
    50                  55                  60                  


His Leu Ser Ser Ala Ala Leu Leu Gln Leu Val Gln Thr Gln Ser Ala 
65                  70                  75                  80  


Gly Gly Val Pro Gln Ala Val Leu Arg Asn Leu Phe Ser Ser Ile His 
                85                  90                  95      


Arg Asn Pro Lys Pro Leu Pro Ala Asn Ala Leu Ala Ala Thr Pro Asn 
            100                 105                 110         


Ser Ser Leu Tyr Ala Ser Leu Thr Ser Leu Ser Ser Ala Ala Ala Leu 
        115                 120                 125             


Pro Gly Ala Gly Pro Ala Tyr Ser Gln Ala Pro Ser Pro Ala Ser Ala 
    130                 135                 140                 


Asp Leu Leu Gln Ser Glu Gln Phe Arg Ser Ala Ala Lys Asn Pro Ser 
145                 150                 155                 160 


Pro Asn Glu Ala Ser Pro Ile Leu Ala Leu Leu Gly Glu Ala Ala Arg 
                165                 170                 175     


Ala Ala Thr Thr Pro Arg Thr Val Pro Ala Leu Ser Ala Val Cys Pro 
            180                 185                 190         


Ala Ala Ser Ser Gly Val Ser Leu Pro Pro Ala Ser Asp Thr Leu Ala 
        195                 200                 205             


Leu Ala Gln Ser Ser Leu Ser Ser Ser Thr Gly Cys Ala Ser Asp Val 
    210                 215                 220                 


Lys Ala Ser Arg Pro Glu Glu His Pro Ala Phe Ala Ser Gly Thr Ala 
225                 230                 235                 240 


Asn Arg Gln Ser Leu Leu Gln Ala Leu Leu Leu Ser Thr Ala Pro Leu 
                245                 250                 255     


Ala Phe Ser Gly Pro Ser Leu Ser Ser Ala Ser Thr Thr Leu Pro Ala 
            260                 265                 270         


Ser Ser Gly Ala Val Ser Ser Arg Asn Ala Gly Ala Tyr Gln Phe Glu 
        275                 280                 285             


Arg Leu Leu Gln Ala Glu Ala Ala Lys Val Lys Ala Leu Leu Pro Asn 
    290                 295                 300                 


Thr Thr Ser Lys Ser Met Ser Gln Ser Ser Val Pro Gln Arg Asp Leu 
305                 310                 315                 320 


Thr Arg Lys Thr Ser Leu Phe Pro Asp Pro Arg Gly Leu Ser Ala Asp 
                325                 330                 335     


Asp Ala Ser Arg Arg Tyr Asn Thr Arg Gly Ala Asn Ser Gly Gly Ala 
            340                 345                 350         


Gly Leu Arg Arg Gly Thr Gly Val His Ala Thr Thr Glu Gln Ser Gly 
        355                 360                 365             


Ala Leu Asp Ala Gly Glu Arg Thr Arg Pro Phe Gly Ala Gly Glu Asp 
    370                 375                 380                 


Glu Ser Ala Gln Gly Lys Pro Asp Ser Arg Gly Arg Gln Arg Pro Gly 
385                 390                 395                 400 


Ala Leu Asp Ala Ser Asn Ile Leu Gly Leu Leu Ala Ala Phe Gln Pro 
                405                 410                 415     


Ser Gln Ala Pro Ala Ile Arg Asp Leu Ser Ala Pro Ser His Leu Ser 
            420                 425                 430         


Ala Ala Ala Thr Gly Ala Leu Pro Leu Thr Ala Ser Phe Thr Ala Ser 
        435                 440                 445             


Ala Leu Ala Ser Ser Gln Cys Leu Pro Ala Gly Thr Pro Ala Ser Ser 
    450                 455                 460                 


Ser Ala Ser Pro Pro Phe Ser Glu Val Leu Ser Thr Thr Glu Glu Ser 
465                 470                 475                 480 


Ser Thr Thr Lys Glu Thr Asp Ala Ser Ala Ser Thr Leu Leu Ala Phe 
                485                 490                 495     


Leu Gln Lys Tyr Ser Ala Val Ser Gly Leu Gly Gly Ala Ser Asp Phe 
            500                 505                 510         


Leu Gly Gln Leu Gln Gly Lys Thr Ser Leu Pro Pro Leu Ser Leu Ala 
        515                 520                 525             


Glu Pro Ser Ser Ala Leu Pro Ser Ser Phe Leu Gly Gly Ser Asp Gly 
    530                 535                 540                 


Gly Thr Ile Asp Thr Arg Asn Gly Asn Gly Glu Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Ile His Leu Phe Gln Ser Ala Phe Arg Met Pro Ser Pro Ser Gln Gln 
                565                 570                 575     


Asn Leu Leu Asp Ala Leu Leu Ala Ser Ser Cys Thr Thr Ala Thr Ser 
            580                 585                 590         


Arg Ser Asp Gly Ser Gly Asn Leu Gly Cys Pro Val Val Asp Glu Arg 
        595                 600                 605             


Asn Ala Lys Leu Ala Gly Pro Ala His Pro Leu Pro Cys Ser Phe Pro 
    610                 615                 620                 


Gln Ile Ser Ser Ser Ser Gly Glu Pro Gly Arg Lys Thr Gly Gly Arg 
625                 630                 635                 640 


Val His Arg Gln Gly Thr Ser Gln Ser Gly Gly Arg Val Arg Ser Gly 
                645                 650                 655     


Lys Asn Gly Gly Ser Ala Ala Pro Pro Arg Gln Ser Ser Ser Asp Asn 
            660                 665                 670         


Val Pro Ser Thr Pro Thr Val Ser Ser His Glu Ala Pro His Arg Ala 
        675                 680                 685             


Gly Phe Pro Ser Gln Thr Pro Tyr Glu Leu Ser Ala Ser Pro Ser His 
    690                 695                 700                 


Gln Leu Asp Leu Leu Arg Leu Gly Ala Phe Leu Gly Gly Ala Gly Lys 
705                 710                 715                 720 


Gln Asp Ala Ser Val His Ser Asp Glu Thr Gly Thr Leu Ser Gly Glu 
                725                 730                 735     


Pro Ser His Arg Ser Cys Ser Leu Ser Arg Gly Leu Thr Gln Glu Ser 
            740                 745                 750         


Val Leu Gln Leu Ser Asp Thr Thr Ser Thr Ser Arg Glu Gly Glu Pro 
        755                 760                 765             


Asn Glu Pro Ser Gln Gly Cys Val Asn Val Ala Ala Ser Leu Pro Ala 
    770                 775                 780                 


Phe Gly Pro Gln Pro Ser Ser Gly Ala Ala Lys Ala Arg Glu Gly Arg 
785                 790                 795                 800 


Arg Gly Ala Gly Gly Ala Gly Ala Ala Pro Pro Val Pro Leu Arg Ala 
                805                 810                 815     


Asp Val Thr Leu Gly Gly Asn Arg Pro His Tyr His Val Ala Lys Gln 
            820                 825                 830         


Glu Trp Arg Val Arg Tyr Tyr Met Asn Gly Lys Arg Lys Met Arg Thr 
        835                 840                 845             


Tyr Ser Ala Lys Phe Tyr Gly Tyr Glu Thr Ala His Thr Met Ala Glu 
    850                 855                 860                 


Asp Phe Ala His Tyr Val Asp Lys His Glu Ala Leu Pro Asp Ser Met 
865                 870                 875                 880 


Met Met Thr Ala Met Met Leu Gln Ala Gln Ala Asn Ser Ala Ala Ser 
                885                 890                 895     


Ser Gly Gln Thr Val Pro Leu Ala Arg Gly Ile Arg Ala Ser Ser Ala 
            900                 905                 910         


Ser Thr Gly Ala Gly Gly His Val Ser Lys Ser Ala Thr Lys Gly Ser 
        915                 920                 925             


Val Ala Ala Ser Ser Glu Gly Ser Thr Ser Met Gly Ser Asp Ala Thr 
    930                 935                 940                 


Arg Ser Gln Glu Gly Glu Ala Ala Glu Leu Cys Pro Leu Ala Ala Gly 
945                 950                 955                 960 


Leu Ser Arg Pro Leu Ala Ser Met His Ser Ala Ala Gly Asn Ala Val 
                965                 970                 975     


Ala Gln Gly Arg Gln Glu Ser Lys Glu Glu Ala Pro Gly Gly Gln Ala 
            980                 985                 990         


Trp Phe Gly Glu Pro Gly Lys Phe  Arg Ala Ser Ser Glu  Ala Ala Leu 
        995                 1000                 1005             


Cys Gly  Ser Gly Ser Ser Ala  Glu Gly Arg Asp Gly  His Glu Ser 
    1010                 1015                 1020             


Glu Val  Leu Trp Ala Thr Leu  Gly Lys Val His Asp  Ala Ser Gln 
    1025                 1030                 1035             


Gly Lys  Lys Ile Lys Pro Glu  Lys Pro Leu Thr Val  Ala Arg Gly 
    1040                 1045                 1050             


Arg Leu  Ala Leu Gly Ala Glu  Asp Lys Ser Gln Asn  Leu Gly Val 
    1055                 1060                 1065             


Asp Leu  Val Asp Ser Gly Glu  Ala Gln Gly Leu Pro  Gly Val Arg 
    1070                 1075                 1080             


Gln Pro  Arg Gln Met Lys Asn  Ser Glu Glu Cys Ser  Leu Arg Asp 
    1085                 1090                 1095             


Ser Asp  Lys Gly Met Ala Leu  Ser Lys Arg Phe Gly  Phe Leu Pro 
    1100                 1105                 1110             


Ser Gln  Thr Pro Ser Cys Asp  Ser Met Thr Leu Pro  Phe Pro Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ala Leu Ser Leu  Ser Ser Ala Leu Ser  Ser Cys Ala 
    1130                 1135                 1140             


Ser Leu  Pro Val Ala His Glu  Gly Asn Asn Phe Gln  Lys Gly His 
    1145                 1150                 1155             


Thr Gly  Asp Ile Val Ala Leu  Ala Ser Gln Ser Gly  Thr Gln Arg 
    1160                 1165                 1170             


Pro Ala  Ser Val Val Leu Ser  Arg Asp Ala Asn Val  Ser Gly Ser 
    1175                 1180                 1185             


Ser Pro  Ser His Pro Thr Trp  Gln Arg Glu Gly Ala  Ala Val Ser 
    1190                 1195                 1200             


Gly Arg  Ala Asp Glu Phe Ser  Ser Leu Ser Val Thr  Pro Ser Thr 
    1205                 1210                 1215             


Val Pro  Leu Ser Ser Phe Thr  Met Glu Asp Ile Lys  Gly Glu Lys 
    1220                 1225                 1230             


Gly Asp  Pro Ser Arg Arg Phe  Ala Leu Val Gly Glu  Ser Met Lys 
    1235                 1240                 1245             


Asn Val  Ser Ala Pro Glu Val  Gln Ala Leu Phe Pro  Thr Ser Ser 
    1250                 1255                 1260             


Ile Ala  Asn Ala Glu Leu Leu  Pro Val Asp Phe Leu  His Ser Asn 
    1265                 1270                 1275             


Ser Cys  Ser Ala Asp Lys Leu  Glu Ser Ser Ile Pro  Arg Gly Leu 
    1280                 1285                 1290             


Ala Gly  Asn Asn Pro Ser Met  Thr Ala Thr Ala Val  Ala Ala Thr 
    1295                 1300                 1305             


Ala Val  Ser His Gln Ile Phe  Asp Thr Ile Thr Leu  Phe Gly Glu 
    1310                 1315                 1320             


Phe Leu  Arg Glu Phe Ala Lys  Glu Lys Val Asn Glu  Phe His Glu 
    1325                 1330                 1335             


Tyr Gly  Leu Glu Ala Ser Pro  Leu Thr Val Glu Ala  Ser Ser Glu 
    1340                 1345                 1350             


Val Ser  Leu Phe Gly Lys Ala  Thr Phe Gly Arg Cys  Pro Val Ala 
    1355                 1360                 1365             


Gly Gly  Ser Thr Pro Ala Gly  Ile Ser Lys Met Ser  Gly Glu Thr 
    1370                 1375                 1380             


Leu Ser  Gly Leu Ser Ala Ser  Glu Leu Ser Leu Val  Ser Ala Arg 
    1385                 1390                 1395             


Thr Asn  Thr Thr Thr Gly Glu  Glu Gln Phe Ala Leu  Ala Arg Gly 
    1400                 1405                 1410             


Leu Phe  Pro Gly Asp Ser Glu  Gly Asp Arg Asp Glu  Lys Lys Pro 
    1415                 1420                 1425             


Gln Leu  Ser Gln Gln Glu Leu  Leu Val Leu Ser His  Ala Leu Val 
    1430                 1435                 1440             


Asn Leu  Thr Ser Ser Thr Tyr  Val Leu Met His Thr  Leu Lys Ala 
    1445                 1450                 1455             


Ser Leu  Ser Lys Ser Thr Glu  Ala Val Gln Leu His  Gln Pro Leu 
    1460                 1465                 1470             


Leu Glu  Ala Ala Ser Glu Ala  Lys Ala Thr Asp Glu  Ala Lys Thr 
    1475                 1480                 1485             


Arg Glu  Glu Gln Glu Ser Ser  Glu Cys Asp His Glu  Tyr Pro Pro 
    1490                 1495                 1500             


Arg Ser  Ser Leu Glu Ala Thr  Thr Gly Ala Leu Pro  Phe Arg Leu 
    1505                 1510                 1515             


Ser Pro  Ala Leu Ser Ala Ser  Ser Lys Asp Leu Pro  Ser Leu Ser 
    1520                 1525                 1530             


Ala Ser  Ala Ser Leu Glu Ser  Val Thr Pro Phe Ala  Gly Leu Pro 
    1535                 1540                 1545             


Leu Glu  Glu Gly Thr Leu Ser  Ala Ser Val Gly Leu  Ala Ser Ser 
    1550                 1555                 1560             


Asp Asp  Glu His Asp Thr Ser  Leu Leu Phe Lys Thr  Glu Ala Ala 
    1565                 1570                 1575             


Lys Lys  Arg Ser Leu Phe Ser  Thr Ala Ala Asp Gly  Asp Glu Ser 
    1580                 1585                 1590             


Arg Thr  Tyr Asn Asp Gly Leu  Gly Gln Pro Met Glu  Glu Glu Ile 
    1595                 1600                 1605             


Arg Ser  Cys Val Ser Thr Ser  Cys Gly Glu Ala Val  Ala Thr Thr 
    1610                 1615                 1620             


Thr Leu  Ser Ala Ile Gly Pro  Gly Thr Gly Ala Ser  Gly Ala Leu 
    1625                 1630                 1635             


Leu Asp  Ser Glu Ser Arg Glu  Ser Leu Gly Glu Lys  Pro Gly Ala 
    1640                 1645                 1650             


Ala Leu  Arg Ala Gly Ala His  Thr Pro Ala Pro Ser  Arg Ala Pro 
    1655                 1660                 1665             


Thr Pro  Ser Arg Thr Phe Ser  Phe Thr Ser Ser Ser  Thr Ala Thr 
    1670                 1675                 1680             


Ser Ala  Ala Leu Leu Cys Asp  Ser Asn Val Val His  Glu Lys Leu 
    1685                 1690                 1695             


Arg Ala  Gln Gly Lys Asp Ser  Glu Ala Gly Glu Arg  Lys Gly Asp 
    1700                 1705                 1710             


Ser Glu  Lys Glu Glu Glu Val  Glu Met Trp Lys Glu  Glu Asp Glu 
    1715                 1720                 1725             


Glu Val  Gln Arg Cys Thr Gly  Ser Ala Glu Thr Asp  Ser Thr Glu 
    1730                 1735                 1740             


Ala Thr  Arg Gly Glu Glu Ala  Trp Arg Arg Gly Lys  Gln Ser Glu 
    1745                 1750                 1755             


Lys Lys  Pro Ser Val Ile Thr  Thr Ala Leu Asn Leu  Leu Glu Thr 
    1760                 1765                 1770             


His Arg  His Leu Ala Leu Thr  Ile Ser Gln Leu Lys  Arg Pro Val 
    1775                 1780                 1785             


Ala Gln  Gln Leu Arg Phe Ile  Leu Pro Ile Ala Ala  Pro Gln Leu 
    1790                 1795                 1800             


Leu Pro  Cys Ile Leu Pro Pro  Ala Ser Phe Gln Gly  Pro Gly Glu 
    1805                 1810                 1815             


Ser Gly  Asp Gly Lys Ala Glu  Ala Glu Ala Lys Gly  Ser Ser Ser 
    1820                 1825                 1830             


Leu Gly  Gln Val Leu Glu Thr  Ala Leu Gly His Gly  Thr Arg Leu 
    1835                 1840                 1845             


Ala Pro  Ser Ala Ser Ala Met  Val Pro Pro Arg Lys  Asp Glu Ala 
    1850                 1855                 1860             


Ala Ser  Ala Val Pro Glu Ala  Lys Thr Phe Thr Gly  Leu Ala Asn 
    1865                 1870                 1875             


Ala Gly  Val Met Arg Glu Ala  Ala Ser Arg Thr Leu  Glu Ala Glu 
    1880                 1885                 1890             


Gln Val  Ser Arg Lys Arg Ser  Arg Glu Glu Val Val  Asp Ser Glu 
    1895                 1900                 1905             


Thr Ala  Gly Asp Glu Gly Asp  Met Glu Asn Val Pro  Glu Thr Leu 
    1910                 1915                 1920             


Asp Ala  Thr Thr Ser Pro Gly  Ser Arg Gln Tyr Asp  Lys Ser Pro 
    1925                 1930                 1935             


Ser Asn  Gly Gly Thr Lys Pro  Pro Ala Thr Ala Lys  Ser Arg Val 
    1940                 1945                 1950             


Ile Arg  Asp Gln Ala Ala Leu  Glu Arg Leu Leu Leu  Ala Pro Phe 
    1955                 1960                 1965             


Gln Asp  Thr Pro Thr Cys Ser  Cys Thr Asp Arg Pro  Cys Pro Cys 
    1970                 1975                 1980             


Asp Arg  Gln Gln Val Ala Asp  Met Ile Tyr Leu Phe  Tyr Ala Val 
    1985                 1990                 1995             


Pro Ala  Arg Gln Gln Ala Glu  Ser Ser Lys Glu Gly  Ser Thr Gln 
    2000                 2005                 2010             


Arg Leu  Gln Phe Ala Ala Arg  Asp Thr Asn Glu Arg  Lys Asp Ala 
    2015                 2020                 2025             


Arg Thr  Gly Glu Glu Thr Gln  Gly Gly Glu Thr Glu  Ala Lys Glu 
    2030                 2035                 2040             


Val Ile  Arg Asp Pro Glu Glu  Arg Gly Val Cys Glu  Gly Ser Ser 
    2045                 2050                 2055             


Ser Gln  Asn Ala His Thr Gln  Phe Asp Ala Glu Thr  Ala Ser Ser 
    2060                 2065                 2070             


Ser Met  Ser Ser Asp Pro Arg  Ala Asp Lys Glu Ser  Asn Ala Gln 
    2075                 2080                 2085             


Asp Ala  His Met Ala Asp Lys  Thr Ser Phe Val Ser  Asp Leu Pro 
    2090                 2095                 2100             


Gln Pro  Ser Gly Glu Phe Ala  Pro Ser Leu Leu Ser  Glu Thr Ser 
    2105                 2110                 2115             


Leu Asp  Val Ala Met Ala Asp  Ser Arg Gly Thr Thr  Ser Glu Ile 
    2120                 2125                 2130             


His Gly  Phe Phe Thr Arg Ser  Asp Glu Gln Lys Arg  Ala Ser Phe 
    2135                 2140                 2145             


Ser Ser  Ser Ser Leu Leu Ala  Ala Gly His Ala Val  Ala Ser Phe 
    2150                 2155                 2160             


Ser Ser  Ser Leu Ala Gly Val  Val Ser Gly Ala Gly  Glu Arg Arg 
    2165                 2170                 2175             


Glu Cys  Ala Gly Pro Ser Leu  Gly Asp Leu Ser Thr  Ile Gly Leu 
    2180                 2185                 2190             


Leu Ser  Leu Ser Tyr Pro Ala  Met Leu Ala Phe Ile  Leu Pro Leu 
    2195                 2200                 2205             


Gln Ser  Leu Leu His Met Val  Ser Gly Met Ile Leu  Thr Leu His 
    2210                 2215                 2220             


Lys Lys  Leu Ile His Arg Phe  Ile Cys Ala His Leu  Arg Leu Val 
    2225                 2230                 2235             


Leu Asp  Asp Asp Met Arg Arg  Pro Ala Gly Gly Ala  Leu Lys Ser 
    2240                 2245                 2250             


Arg Gly  Ala His Gly Asp Thr  Glu Ala Ala Glu Ala  Gln Val Glu 
    2255                 2260                 2265             


Arg Arg  Arg Arg Glu His Glu  Arg Glu Glu Thr Thr  Asn Leu Ala 
    2270                 2275                 2280             


Ile Gly  Tyr Arg Glu Gly Asn  Ala Glu Ala Ser Asn  Thr Phe Pro 
    2285                 2290                 2295             


Leu Val  Asp Thr Val Ser Ser  Leu Leu Ser Pro Gly  Ser Leu Arg 
    2300                 2305                 2310             


Gln Glu  Asn Ser Glu Val Glu  Arg Arg Asp Asn Asp  Glu Glu Arg 
    2315                 2320                 2325             


Leu Glu  Leu Ile Thr Gly Ile  Ala Arg Glu Ser Pro  Lys Pro Ser 
    2330                 2335                 2340             


Glu Lys  Asp Ser Val Ser Pro  Phe Leu Ser Thr Ala  Pro Cys Pro 
    2345                 2350                 2355             


Gly Thr  Glu Ala Glu Ser Ser  Asp Cys Ser Ala Ser  Ser Ala Cys 
    2360                 2365                 2370             


Ser Gly  Thr Pro Thr Glu Gly  Thr Glu Gly Gly Glu  Thr Gly Asp 
    2375                 2380                 2385             


Ile Ala  Ser Phe Leu Ser Pro  Ser Gly Asp Val Lys  Gln Thr Ile 
    2390                 2395                 2400             


Met Leu  Ala 
    2405     


<210>  22
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Leu Lys Thr Ser Trp His Cys Ser Cys Asn Ala Thr Phe Pro 
1               5                   10                  15      


Gly Asp Leu Leu Met Val Val Ala Asn His Asp Arg Val Gly Asn Trp 
            20                  25                  30          


Asn Pro Gln Asn Ser Val Val Leu Ser Thr Asp Ala Ser Ser Phe Pro 
        35                  40                  45              


Thr Trp Arg Ser Gly Glu Val Cys Phe Asp Glu Gln Gln Pro Val Arg 
    50                  55                  60                  


Leu Glu Tyr Lys Leu Ile Ile Arg Arg Ala Ser Gly Glu Ile Tyr Trp 
65                  70                  75                  80  


Glu Pro Ile Pro Thr Asn Arg Val Val Thr Leu Thr Ala Asn Thr Ser 
                85                  90                  95      


Ser Val Ile Glu Asn Val Trp Gly Ser Leu Ala Thr Cys Ser Ile Thr 
            100                 105                 110         


Phe Phe Pro Leu Gln Pro Ile Pro Ser Pro Ser Phe Tyr Lys His Ala 
        115                 120                 125             


Glu Arg Thr Lys Lys Glu Ala Ser Ser Val His Leu His Ser Ala Ser 
    130                 135                 140                 


Ile Ser Asp Asp Ser Gly Ser Asp Thr Gly Thr Cys Ser Gln Val Asp 
145                 150                 155                 160 


Glu Ser Arg Thr Gln Arg Asn Val Arg Gly Gln Pro Ala Ser Val Gly 
                165                 170                 175     


Thr Gly Lys Ala Thr Ala Ala Glu Arg Gly Gly Lys Gly Tyr Val Met 
            180                 185                 190         


Pro His His Gln Cys Ser Thr Ser Gln Arg Arg His Ser Ile Ser Thr 
        195                 200                 205             


Gln Ala Ala Asp Glu Ala Ala Gly Gly Gly Asn Arg Val Ser Phe Lys 
    210                 215                 220                 


Arg Ser Ala Phe Ile Leu Ala Asn Thr Gly Pro Ile Thr Asn Tyr Tyr 
225                 230                 235                 240 


Thr Val Ser Lys Thr Ile Gly Arg Gly Thr Trp Gly Glu Val Lys Leu 
                245                 250                 255     


Val Ile Asp Asn Gly Thr Gly Ala Arg Arg Ala Ala Lys Lys Ile Pro 
            260                 265                 270         


Lys Cys Tyr Val Glu Asp Ala Asp Arg Phe Arg Gln Glu Ile Glu Ile 
        275                 280                 285             


Met Lys Ser Leu Asp His Pro Asn Ile Val Arg Leu Tyr Glu Thr Phe 
    290                 295                 300                 


Glu Asp Met Thr Asp Phe Tyr Leu Val Met Glu Tyr Cys Thr Gly Gly 
305                 310                 315                 320 


Glu Leu Phe Asp Arg Leu Val His Gln Gly Val Phe Thr Glu Ala Leu 
                325                 330                 335     


Ala Cys Arg Ile Met Arg Gln Ile Leu Ala Ala Val Ala Tyr Cys His 
            340                 345                 350         


Ala His Arg Val Ala His Arg Asp Leu Lys Pro Glu Asn Phe Leu Phe 
        355                 360                 365             


Leu His Asp Asn Pro Glu Ser Pro Ile Lys Leu Ile Asp Phe Gly Leu 
    370                 375                 380                 


Ala Ala Arg Phe Lys Ser Gly Gln Pro Met Arg Thr Arg Ala Gly Thr 
385                 390                 395                 400 


Pro Tyr Tyr Val Ser Pro Gln Val Leu Glu Gly Arg Tyr Gly Pro Glu 
                405                 410                 415     


Cys Asp Val Trp Ser Ala Gly Val Met Met Tyr Ile Leu Leu Cys Gly 
            420                 425                 430         


Tyr Pro Pro Phe Asn Ala Pro Ser Asp Arg Ala Ile Met Asn Lys Val 
        435                 440                 445             


Arg Ala Gly His Tyr Thr Phe Pro Asp Ser Glu Trp Ser Arg Val Ser 
    450                 455                 460                 


Leu Gln Ala Lys Asp Leu Ile Ser Arg Leu Leu Asp Arg His Pro Arg 
465                 470                 475                 480 


Thr Arg Ile Ser Ala Glu Gln Ala Leu Arg His Ala Trp Phe Ala Met 
                485                 490                 495     


His Ala Pro Gly Asp His Phe Glu Pro Leu Gly Leu Asp Ile Leu Ser 
            500                 505                 510         


Lys Phe Arg Arg Phe Gln Gly Leu Ser Arg Leu Lys Lys Leu Ala Leu 
        515                 520                 525             


Thr Val Ile Ala Gln His Leu Glu Asp Ser Glu Ile Glu Gly Leu Lys 
    530                 535                 540                 


Asn Leu Phe Thr Gln Leu Asp Thr Glu Gly Asp Gly Val Leu Thr Val 
545                 550                 555                 560 


Glu Glu Ile Arg Lys Gly Ile Glu Arg Ser Gly Val His Leu Pro Pro 
                565                 570                 575     


Asp Met Val Leu Glu Asp Val Leu Arg Glu Val Asp Thr Ala Gly Thr 
            580                 585                 590         


Gly Ser Ile Asp Tyr Thr Glu Phe Ile Ala Ala Cys Leu His Gln Ser 
        595                 600                 605             


His Tyr Ile Arg Glu Glu Ala Cys Arg Ala Ala Phe Arg Val Leu Asp 
    610                 615                 620                 


Ile Asn Gly Asp Gly Leu Val Ser Ala Gln Glu Leu Arg Gln Val Phe 
625                 630                 635                 640 


His Met Ala Gly Asp Leu Glu Thr Asp Ala Ala Ala Glu Leu Leu Glu 
                645                 650                 655     


Ala Asp Ala Asp Gly Asp Gly His Ile Thr Phe Asp Glu Phe Cys Gly 
            660                 665                 670         


Leu Met Arg Lys Val Pro Ser Leu Ala Leu Val Thr Glu His Thr Val 
        675                 680                 685             


Ser Met Met Arg Arg Thr Cys Ser Arg Thr Asn Ile Ser Glu Ala Ser 
    690                 695                 700                 


Leu Thr Pro Arg Ala Thr Gly 
705                 710     


<210>  23
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Val Ser Arg Thr Leu Ser Leu Ser Met Ser Leu Phe Arg Ala His 
1               5                   10                  15      


Leu Val Phe Tyr Arg Cys Ala Leu Asn Leu Asn Ser Ser Tyr Asn Phe 
            20                  25                  30          


Gly Phe Leu Val Ala Met Thr Phe Val Leu Gln Ile Ile Thr Gly Ile 
        35                  40                  45              


Thr Leu Ala Phe Arg Tyr Thr Ser Glu Ala Ser Cys Ala Phe Ala Ser 
    50                  55                  60                  


Val Gln His Leu Val Arg Glu Val Ala Ala Gly Trp Glu Phe Arg Met 
65                  70                  75                  80  


Leu His Ala Thr Thr Ala Ser Phe Val Phe Leu Cys Ile Leu Ile His 
                85                  90                  95      


Met Thr Arg Gly Leu Tyr Asn Trp Ser Tyr Ser Tyr Leu Thr Thr Ala 
            100                 105                 110         


Trp Met Ser Gly Leu Val Leu Tyr Leu Leu Thr Ile Ala Thr Ala Phe 
        115                 120                 125             


Leu Gly Tyr Val Leu Pro Trp Gly Gln Met Ser Phe Trp Gly Ala Thr 
    130                 135                 140                 


Val Ile Thr Asn Leu Leu Ser Pro Ile Pro Tyr Leu Val Pro Trp Leu 
145                 150                 155                 160 


Leu Gly Gly Tyr Tyr Val Ser Asp Val Thr Leu Lys Arg Phe Phe Val 
                165                 170                 175     


Leu His Phe Ile Leu Pro Phe Ile Gly Cys Ile Ile Ile Val Leu His 
            180                 185                 190         


Ile Phe Tyr Leu His Leu Asn Gly Ser Ser Asn Pro Ala Gly Ile Asp 
        195                 200                 205             


Thr Ala Leu Lys Val Ala Phe Tyr Pro His Met Leu Met Thr Asp Ala 
    210                 215                 220                 


Lys Cys Leu Ser Tyr Leu Ile Gly Leu Ile Phe Leu Gln Ala Ala Phe 
225                 230                 235                 240 


Gly Leu Met Glu Leu Ser His Pro Asp Asn Ser Ile Pro Val Asn Arg 
                245                 250                 255     


Phe Val Thr Pro Leu His Ile Val Pro Glu Trp Tyr Phe Leu Ala Tyr 
            260                 265                 270         


Tyr Ala Val Leu Lys Val Ile Pro Ser Lys Thr Gly Gly Leu Leu Val 
        275                 280                 285             


Phe Met Ser Ser Leu Ile Asn Leu Gly Leu Leu Ser Glu Ile Arg Ala 
    290                 295                 300                 


Leu Asn Thr Arg Met Leu Ile Arg Gln Gln Phe Met Thr Arg Asn Val 
305                 310                 315                 320 


Val Ser Gly Trp Val Ile Ile Trp Val Tyr Ser Met Ile Phe Leu Ile 
                325                 330                 335     


Ile Ile Gly Ser Ala Ile Pro Gln Ala Thr Tyr Ile Leu Tyr Gly Arg 
            340                 345                 350         


Leu Ala Thr Ile Leu Tyr Leu Thr Thr Gly Leu Val Leu Cys Leu Tyr 
        355                 360                 365             


<210>  24
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Leu Cys Lys Tyr His His Phe Leu Cys Ser Leu Thr Ser Gln Leu 
1               5                   10                  15      


Ser Tyr Leu Ile Gly Leu Ile Phe Leu Gln Ala Ala Phe Gly Leu Met 
            20                  25                  30          


Glu Leu Ser His Pro Asp Asn Ser Ile Pro Val Asn Arg Phe Val Thr 
        35                  40                  45              


Pro Leu His Ile Val Pro Glu Trp Tyr Phe Leu Ala Tyr Tyr Ala Val 
    50                  55                  60                  


Leu Lys Val Ile Pro Ser Lys Thr Gly Gly Leu Leu Val Phe Met Ser 
65                  70                  75                  80  


Ser Thr Cys Gln 
                


<210>  25
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ile Ala Val His His His Pro Thr Gly Leu Leu Lys Thr Ala Lys 
1               5                   10                  15      


Ser Val Gly Phe Gln Tyr Pro Thr Thr Leu Arg Leu Phe His Ile Gly 
            20                  25                  30          


Tyr Val Leu Gly Val Ile Tyr Gly Leu Leu Leu Ser Leu Val Leu Thr 
        35                  40                  45              


Ala Arg Glu Asn Tyr Tyr Ser Asp Ala Ser Met Ile Ser Thr Ile Val 
    50                  55                  60                  


Leu Gly Val Ile Ile Ser Glu Thr Gly Leu Phe Ile Ser Phe Phe Trp 
65                  70                  75                  80  


Gly Val Tyr Thr Thr Ser Trp Thr Thr Gly Leu Asp Leu Glu Gly Leu 
                85                  90                  95      


Cys Leu Pro Asp Pro Ser Ser Ile Val Leu Phe Met Thr Ile Met Leu 
            100                 105                 110         


Ser Ala Leu Ser Ile Val Val Ser Ser Val Tyr Leu Lys Asn Gln His 
        115                 120                 125             


Leu Tyr Thr Ser Cys Thr Asn Ile Met Ile Phe Thr Leu Val Val Ser 
    130                 135                 140                 


Phe Leu Met Leu Val Cys Thr Glu Tyr Leu Gly Leu Ser Ile Tyr Ile 
145                 150                 155                 160 


Asn Asp Asn Gly Phe Gly Asn Gly Leu Phe Ile Leu Thr Gly Ile His 
                165                 170                 175     


Phe Ser His Val Ile Val Gly Ala Ile Leu Gly Phe Phe Asn Gln Gly 
            180                 185                 190         


Met Tyr Ser Ser Leu Val Thr Tyr Leu Pro Val Asn Cys Ile Thr Leu 
        195                 200                 205             


Ser Lys Cys Lys Gly Thr Leu Cys Lys Ile Phe Ser Glu Pro Phe Thr 
    210                 215                 220                 


Ile Leu Tyr Leu His Phe Val Glu Ala Val Trp Ile Met Ile His Val 
225                 230                 235                 240 


Thr Phe Tyr Leu 
                


<210>  26
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Leu Phe Arg Ala His Leu Val Phe Tyr Arg Cys Ala Leu Asn 
1               5                   10                  15      


Leu Asn Ser Ser Tyr Asn Phe Gly Phe Leu Val Ala Met Thr Phe Val 
            20                  25                  30          


Leu Gln Ile Ile Thr Gly Ile Thr Leu Ala Phe Arg Tyr Thr Ser Glu 
        35                  40                  45              


Ala Ser Cys Ala Phe Ala Ser Val Gln His Leu Val Arg Glu Val Ala 
    50                  55                  60                  


Ala Gly Trp Glu Phe Arg Met Leu His Ala Thr Thr Ala Ser Phe Val 
65                  70                  75                  80  


Phe Leu Cys Ile Leu Ile His Met Thr Arg Gly Leu Tyr Asn Trp Ser 
                85                  90                  95      


Tyr Ser Tyr Leu Thr Thr Ala Trp Met Ser Gly Leu Val Leu Tyr Leu 
            100                 105                 110         


Leu Thr Ile Ala Thr Ala Phe Leu Gly Tyr Ala Thr Ser Asn Tyr Thr 
        115                 120                 125             


Thr Leu Cys Gln Glu Gly Ser Gln Ile Thr Leu Ile Ile Phe Val Ile 
    130                 135                 140                 


Leu Ile His Gly Val Gln Leu Val Leu Phe Leu Gln 
145                 150                 155     


<210>  27
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  27

Trp Ala His His Met Met Thr Val Gly Leu Glu Val Asp Thr Arg Ala 
1               5                   10                  15      


Tyr Phe Ser Ala Met Thr Ile Met Ile Ala Ile Pro Thr Gly Thr Lys 
            20                  25                  30          


Ile Phe Asn Trp Leu Gly Thr Tyr Met Ala Ser His Asn Thr Thr Arg 
        35                  40                  45              


Thr Ile Asp Leu Trp Ala Ala Leu Cys Phe Ile Leu Leu Phe Thr Leu 
    50                  55                  60                  


Gly Gly Thr Thr Gly Val Val Met Gly Asn Ala Gly Met Asp Ile Ala 
65                  70                  75                  80  


Leu His Asp Thr Tyr Tyr Ile Val Ala His Phe His Phe Val Leu Ser 
                85                  90                  95      


Leu Gly Ala Ile Leu Ala Thr Ile Cys Gly Phe Val Phe Tyr Ser Lys 
            100                 105                 110         


Asp Met Phe Gly Asp Thr Leu Asn Leu Phe His Val Asn Thr Gly Ser 
        115                 120                 125             


Ser Pro Tyr Leu Asn Ile Trp Phe Val Val Phe Leu Ala Ser Ile Met 
    130                 135                 140                 


Leu Ile Phe Leu Pro Met His Ile Leu Gly Phe Asn Val Met Pro Arg 
145                 150                 155                 160 


Arg Ile Pro Asp Tyr Pro Asp Tyr Leu Cys Tyr Ile Asn Thr Trp Cys 
                165                 170                 175     


Ser Ile Val Gln Leu Val Val Tyr Thr Pro Gln Lys Lys Leu Ile Asn 
            180                 185                 190         


Asn Pro Val Ser Glu Met Ile Thr Pro Ser Thr Met Val Leu Ile Ile 
        195                 200                 205             


Leu Ala Ser Glu Tyr Tyr Ser Tyr Leu Thr Thr Ala Trp Met Ser Gly 
    210                 215                 220                 


Leu Val Leu Tyr Leu Leu Thr Ile Ala Thr Ala Phe Leu Gly Tyr Val 
225                 230                 235                 240 


Leu Pro Trp Gly Gln Met Ser Phe Trp Gly Ala Thr Val Ile Thr Asn 
                245                 250                 255     


Leu Leu Ser Pro Ile Pro Tyr Leu Val Pro Trp Leu Leu Gly Gly Tyr 
            260                 265                 270         


Tyr Val Ser Asp Val Thr Leu Lys Arg Phe Phe Val Leu His Phe Ile 
        275                 280                 285             


Leu Pro Phe Ile Gly Cys Ile Ile Ile Val Leu His Ile Phe Tyr Leu 
    290                 295                 300                 


His Leu Asn Gly Ser Ser Asn Pro Ala Gly Ile Asp Thr Ala Leu Lys 
305                 310                 315                 320 


Val Ala Phe Tyr Pro His Met Leu Met Thr Asp Ala Lys Cys Leu Ser 
                325                 330                 335     


Tyr Leu Ile Gly Leu Ile Phe Leu Gln Ala Ala Phe Gly Leu Met Glu 
            340                 345                 350         


Leu Ser His Pro Asp Asn Ser Ile Pro Val Asn Arg Phe Val Thr Pro 
        355                 360                 365             


Leu His Ile Val Pro Glu Trp Tyr Phe Leu Ala Tyr Tyr Ala Val Leu 
    370                 375                 380                 


Lys Val Ile Pro Ser Lys Thr Gly Gly Leu Leu Val Phe Met Ser Ser 
385                 390                 395                 400 


Thr Cys Gln 
            


