                               SEQUENCE LISTING

<110> BIOGEN MA INC.
 
<120> DKK2 CYSTEINE RICH DOMAIN 2 CONTAINING PROTEINS AND USES THEREOF

<130> 13751-0239WO1

<140>
<141>

<150> 62/387,116
<151> 2015-12-23

<160> 102   

<170> PatentIn version 3.5

<210> 1
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu 
            20                  25                  30          


Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp 
        35                  40                  45              


Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys 
    50                  55                  60                  


Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp 
65                  70                  75                  80  


Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser 
                85                  90                  95      


Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
            100                 105         


<210> 2
<211> 88
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys 
    50                  55                  60                  


Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala 
65                  70                  75                  80  


Arg Leu His Val Cys Gln Lys Ile 
                85              


<210> 3
<211> 253
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Ser Gln Ile Gly Ser Ser Arg Ala Lys Leu Asn Ser Ile 
            20                  25                  30          


Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly Gln Ala Ala Asn Arg Ser 
        35                  40                  45              


Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly Gly Ser Lys Lys Gly Lys 
    50                  55                  60                  


Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser Asp Lys Glu Cys Glu Val 
65                  70                  75                  80  


Gly Arg Tyr Cys His Ser Pro His Gln Gly Ser Ser Ala Cys Met Val 
                85                  90                  95      


Cys Arg Arg Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys Cys Pro 
            100                 105                 110         


Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu Ser Ile 
        115                 120                 125             


Leu Thr Pro His Ile Pro Ala Leu Asp Gly Thr Arg His Arg Asp Arg 
    130                 135                 140                 


Asn His Gly His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn Leu Gly 
145                 150                 155                 160 


Arg Pro His Thr Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro 
                165                 170                 175     


Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His 
            180                 185                 190         


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys 
        195                 200                 205             


Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
    210                 215                 220                 


Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr 
225                 230                 235                 240 


Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
                245                 250             


<210> 4
<211> 234
<212> PRT
<213> Homo sapiens

<400> 4
Ser Gln Ile Gly Ser Ser Arg Ala Lys Leu Asn Ser Ile Lys Ser Ser 
1               5                   10                  15      


Leu Gly Gly Glu Thr Pro Gly Gln Ala Ala Asn Arg Ser Ala Gly Met 
            20                  25                  30          


Tyr Gln Gly Leu Ala Phe Gly Gly Ser Lys Lys Gly Lys Asn Leu Gly 
        35                  40                  45              


Gln Ala Tyr Pro Cys Ser Ser Asp Lys Glu Cys Glu Val Gly Arg Tyr 
    50                  55                  60                  


Cys His Ser Pro His Gln Gly Ser Ser Ala Cys Met Val Cys Arg Arg 
65                  70                  75                  80  


Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys Cys Pro Ser Thr Arg 
                85                  90                  95      


Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu Ser Ile Leu Thr Pro 
            100                 105                 110         


His Ile Pro Ala Leu Asp Gly Thr Arg His Arg Asp Arg Asn His Gly 
        115                 120                 125             


His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn Leu Gly Arg Pro His 
    130                 135                 140                 


Thr Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg 
145                 150                 155                 160 


Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr 
                165                 170                 175     


Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln 
            180                 185                 190         


Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys 
        195                 200                 205             


Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser 
    210                 215                 220                 


Lys Ala Arg Leu His Val Cys Gln Lys Ile 
225                 230                 


<210> 5
<211> 107
<212> PRT
<213> Mus sp.

<400> 5
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Met Pro His Ile Lys Gly His Glu Gly Asp Pro Cys Leu 
            20                  25                  30          


Arg Ser Ser Asp Cys Ile Asp Gly Phe Cys Cys Ala Arg His Phe Trp 
        35                  40                  45              


Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys 
    50                  55                  60                  


Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp 
65                  70                  75                  80  


Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser 
                85                  90                  95      


Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
            100                 105         


<210> 6
<211> 88
<212> PRT
<213> Mus sp.

<400> 6
Met Pro His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ile Asp Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys 
    50                  55                  60                  


Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala 
65                  70                  75                  80  


Arg Leu His Val Cys Gln Lys Ile 
                85              


<210> 7
<211> 253
<212> PRT
<213> Mus sp.

<400> 7
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Ser Gln Leu Gly Ser Ser Arg Ala Lys Leu Asn Ser Ile 
            20                  25                  30          


Lys Ser Ser Leu Gly Gly Glu Thr Pro Ala Gln Ser Ala Asn Arg Ser 
        35                  40                  45              


Ala Gly Met Asn Gln Gly Leu Ala Phe Gly Gly Ser Lys Lys Gly Lys 
    50                  55                  60                  


Ser Leu Gly Gln Ala Tyr Pro Cys Ser Ser Asp Lys Glu Cys Glu Val 
65                  70                  75                  80  


Gly Arg Tyr Cys His Ser Pro His Gln Gly Ser Ser Ala Cys Met Leu 
                85                  90                  95      


Cys Arg Arg Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys Cys Pro 
            100                 105                 110         


Gly Thr Arg Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu Ser Ile 
        115                 120                 125             


Leu Thr Pro His Ile Pro Ala Leu Asp Gly Thr Arg His Arg Asp Arg 
    130                 135                 140                 


Asn His Gly His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn Leu Gly 
145                 150                 155                 160 


Arg Pro His Ser Lys Met Pro His Ile Lys Gly His Glu Gly Asp Pro 
                165                 170                 175     


Cys Leu Arg Ser Ser Asp Cys Ile Asp Gly Phe Cys Cys Ala Arg His 
            180                 185                 190         


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys 
        195                 200                 205             


Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
    210                 215                 220                 


Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr 
225                 230                 235                 240 


Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
                245                 250             


<210> 8
<211> 234
<212> PRT
<213> Mus sp.

<400> 8
Ser Gln Leu Gly Ser Ser Arg Ala Lys Leu Asn Ser Ile Lys Ser Ser 
1               5                   10                  15      


Leu Gly Gly Glu Thr Pro Ala Gln Ser Ala Asn Arg Ser Ala Gly Met 
            20                  25                  30          


Asn Gln Gly Leu Ala Phe Gly Gly Ser Lys Lys Gly Lys Ser Leu Gly 
        35                  40                  45              


Gln Ala Tyr Pro Cys Ser Ser Asp Lys Glu Cys Glu Val Gly Arg Tyr 
    50                  55                  60                  


Cys His Ser Pro His Gln Gly Ser Ser Ala Cys Met Leu Cys Arg Arg 
65                  70                  75                  80  


Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys Cys Pro Gly Thr Arg 
                85                  90                  95      


Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu Ser Ile Leu Thr Pro 
            100                 105                 110         


His Ile Pro Ala Leu Asp Gly Thr Arg His Arg Asp Arg Asn His Gly 
        115                 120                 125             


His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn Leu Gly Arg Pro His 
    130                 135                 140                 


Ser Lys Met Pro His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg 
145                 150                 155                 160 


Ser Ser Asp Cys Ile Asp Gly Phe Cys Cys Ala Arg His Phe Trp Thr 
                165                 170                 175     


Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln 
            180                 185                 190         


Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys 
        195                 200                 205             


Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser 
    210                 215                 220                 


Lys Ala Arg Leu His Val Cys Gln Lys Ile 
225                 230                 


<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 9
His His His His His His 
1               5       


<210> 10
<211> 771
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccctg      480

gtgccgcgtg gcagcatgcc gcacattaaa ggccatgaag gcgatccgtg cctgcgtagc      540

tctgattgca ttgatggctt ttgttgcgcg cgtcattttt ggaccaaaat ttgtaaaccg      600

gtgctgcatc agggcgaagt gtgcaccaaa cagcgtaaaa aaggcagcca tgggctggag      660

atctttcagc gttgcgattg cgcgaaaggc ctgagctgca aagtgtggaa agatgcaacc      720

tatagcagca aagcgcgtct gcatgtgtgc cagaagatat aatgaggatc c               771


<210> 11
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Leu 
145                 150                 155                 160 


Val Pro Arg Gly Ser Met Pro His Ile Lys Gly His Glu Gly Asp Pro 
                165                 170                 175     


Cys Leu Arg Ser Ser Asp Cys Ile Asp Gly Phe Cys Cys Ala Arg His 
            180                 185                 190         


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys 
        195                 200                 205             


Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
    210                 215                 220                 


Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr 
225                 230                 235                 240 


Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
                245                 250             


<210> 12
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


Ser Gln Ile Gly Ser Ser Arg Ala Lys Leu Asn Ser Ile Lys Ser Ser 
145                 150                 155                 160 


Leu Gly Gly Glu Thr Pro Gly Gln Ala Ala Asn Arg Ser Ala Gly Met 
                165                 170                 175     


Tyr Gln Gly Leu Ala Phe Gly Gly Ser Lys Lys Gly Lys Asn Leu Gly 
            180                 185                 190         


Gln Ala Tyr Pro Cys Ser Ser Asp Lys Glu Cys Glu Val Gly Arg Tyr 
        195                 200                 205             


Cys His Ser Pro His Gln Gly Ser Ser Ala Cys Met Val Cys Arg Arg 
    210                 215                 220                 


Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys Cys Pro Ser Thr Arg 
225                 230                 235                 240 


Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu Ser Ile Leu Thr Pro 
                245                 250                 255     


His Ile Pro Ala Leu Asp Gly Thr Arg His Arg Asp Arg Asn His Gly 
            260                 265                 270         


His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn Leu Gly Arg Pro His 
        275                 280                 285             


Thr Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg 
    290                 295                 300                 


Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr 
305                 310                 315                 320 


Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln 
                325                 330                 335     


Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys 
            340                 345                 350         


Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser 
        355                 360                 365             


Lys Ala Arg Leu His Val Cys Gln Lys Ile 
    370                 375             


<210> 13
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
145                 150                 155                 160 


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
                165                 170                 175     


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
            180                 185                 190         


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
        195                 200                 205             


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
    210                 215                 220                 


His Val Cys Gln Lys Ile 
225                 230 


<210> 14
<211> 703
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Ala Ala Ala Met Ser His Ile Lys Gly His Glu Gly 
    610                 615                 620                 


Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala 
625                 630                 635                 640 


Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu 
                645                 650                 655     


Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe 
            660                 665                 670         


Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp 
        675                 680                 685             


Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
    690                 695                 700             


<210> 15
<211> 2112
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

tccaggggtg tgtttcgtcg agatgcacac aagagtgagg ttgctcatcg gtttaaagat      120

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      180

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      240

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      300

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      360

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      420

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      480

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      540

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      600

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct      660

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca      720

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag      780

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt      840

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt      900

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg      960

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1020

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1080

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1140

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1200

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1260

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1320

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1380

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1440

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1500

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1560

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1620

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagcttgtg     1680

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     1740

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     1800

aaacttgttg ctgcaagtca agctgcctta ggcttagctg ccgcaatgtc acatataaaa     1860

gggcatgaag gagacccctg cctacgatca tcagactgca ttgaagggtt ttgctgtgct     1920

cgtcatttct ggaccaaaat ctgcaaacca gtgctccatc agggggaagt ctgtaccaaa     1980

caacgcaaga agggttctca tgggctggaa attttccagc gttgcgactg tgcgaagggc     2040

ctgtcttgca aagtatggaa agatgccacc tactcctcca aagccagact ccatgtgtgt     2100

cagaaaattt ga                                                         2112


<210> 16
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Gly Ser Met Pro His Ile Lys Gly His Glu Gly Asp 
    610                 615                 620                 


Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg 
625                 630                 635                 640 


His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val 
                645                 650                 655     


Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln 
            660                 665                 670         


Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala 
        675                 680                 685             


Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
    690                 695                 700         


<210> 17
<211> 2109
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

tccaggggtg tgtttcgtcg agatgcacac aagagtgagg ttgctcatcg gtttaaagat      120

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      180

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      240

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      300

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      360

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      420

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      480

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      540

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      600

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct      660

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca      720

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag      780

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt      840

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt      900

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg      960

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1020

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1080

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1140

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1200

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1260

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1320

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1380

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1440

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1500

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1560

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1620

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagcttgtg     1680

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     1740

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     1800

aaacttgttg ctgcaagtca agctgcctta ggcttaggct ctatgcctca tataaaaggg     1860

catgaaggag acccctgcct acgatcatca gactgcattg aagggttttg ctgtgctcgt     1920

catttctgga ccaaaatctg caaaccagtg ctccatcagg gggaagtctg taccaaacaa     1980

cgcaagaagg gttctcatgg gctggaaatt ttccagcgtt gcgactgtgc gaagggcctg     2040

tcttgcaaag tatggaaaga tgccacctac tcctccaaag ccagactcca tgtgtgtcag     2100

aaaatttga                                                             2109


<210> 18
<211> 700
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Gly Ser His Ile Lys Gly His Glu Gly Asp Pro Cys 
    610                 615                 620                 


Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe 
625                 630                 635                 640 


Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr 
                645                 650                 655     


Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys 
            660                 665                 670         


Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr 
        675                 680                 685             


Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
    690                 695                 700 


<210> 19
<211> 2103
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

tccaggggtg tgtttcgtcg agatgcacac aagagtgagg ttgctcatcg gtttaaagat      120

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      180

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      240

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      300

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      360

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      420

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      480

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      540

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      600

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct      660

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca      720

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag      780

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt      840

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt      900

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg      960

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1020

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1080

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1140

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1200

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1260

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1320

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1380

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1440

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1500

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1560

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1620

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagcttgtg     1680

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     1740

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     1800

aaacttgttg ctgcaagtca agctgcctta ggcttaggct ctcatataaa agggcatgaa     1860

ggagacccct gcctacgatc atcagactgc attgaagggt tttgctgtgc tcgtcatttc     1920

tggaccaaaa tctgcaaacc agtgctccat cagggggaag tctgtaccaa acaacgcaag     1980

aagggttctc atgggctgga aattttccag cgttgcgact gtgcgaaggg cctgtcttgc     2040

aaagtatgga aagatgccac ctactcctcc aaagccagac tccatgtgtg tcagaaaatt     2100

tga                                                                   2103


<210> 20
<211> 698
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Gly Ser Lys Gly His Glu Gly Asp Pro Cys Leu Arg 
    610                 615                 620                 


Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr 
625                 630                 635                 640 


Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln 
                645                 650                 655     


Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys 
            660                 665                 670         


Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser 
        675                 680                 685             


Lys Ala Arg Leu His Val Cys Gln Lys Ile 
    690                 695             


<210> 21
<211> 2097
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

tccaggggtg tgtttcgtcg agatgcacac aagagtgagg ttgctcatcg gtttaaagat      120

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      180

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      240

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      300

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      360

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      420

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      480

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      540

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      600

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct      660

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca      720

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag      780

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt      840

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt      900

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg      960

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1020

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1080

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1140

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1200

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1260

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1320

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1380

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1440

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1500

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1560

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1620

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagcttgtg     1680

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     1740

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     1800

aaacttgttg ctgcaagtca agctgcctta ggcttaggct ctaaagggca tgaaggagac     1860

ccctgcctac gatcatcaga ctgcattgaa gggttttgct gtgctcgtca tttctggacc     1920

aaaatctgca aaccagtgct ccatcagggg gaagtctgta ccaaacaacg caagaagggt     1980

tctcatgggc tggaaatttt ccagcgttgc gactgtgcga agggcctgtc ttgcaaagta     2040

tggaaagatg ccacctactc ctccaaagcc agactccatg tgtgtcagaa aatttga        2097


<210> 22
<211> 696
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Gly Ser His Glu Gly Asp Pro Cys Leu Arg Ser Ser 
    610                 615                 620                 


Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
625                 630                 635                 640 


Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys 
                645                 650                 655     


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys 
            660                 665                 670         


Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala 
        675                 680                 685             


Arg Leu His Val Cys Gln Lys Ile 
    690                 695     


<210> 23
<211> 2091
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

tccaggggtg tgtttcgtcg agatgcacac aagagtgagg ttgctcatcg gtttaaagat      120

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      180

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      240

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      300

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      360

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      420

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      480

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      540

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      600

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct      660

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca      720

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag      780

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt      840

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt      900

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg      960

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1020

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1080

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1140

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1200

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1260

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1320

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1380

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1440

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1500

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1560

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1620

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagcttgtg     1680

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     1740

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     1800

aaacttgttg ctgcaagtca agctgcctta ggcttaggct ctcatgaagg agacccctgc     1860

ctacgatcat cagactgcat tgaagggttt tgctgtgctc gtcatttctg gaccaaaatc     1920

tgcaaaccag tgctccatca gggggaagtc tgtaccaaac aacgcaagaa gggttctcat     1980

gggctggaaa ttttccagcg ttgcgactgt gcgaagggcc tgtcttgcaa agtatggaaa     2040

gatgccacct actcctccaa agccagactc catgtgtgtc agaaaatttg a              2091


<210> 24
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 25
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccaaa caacgcaaga agggttctca tgggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgca aagtatggaa agatgccacc     2040

tactcctcca aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 26
<211> 703
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys 
            20                  25                  30          


Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe 
        35                  40                  45              


Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr 
    50                  55                  60                  


Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys 
65                  70                  75                  80  


Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr 
                85                  90                  95      


Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile Gly Gly Ala Ser 
            100                 105                 110         


Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg 
        115                 120                 125             


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
    130                 135                 140                 


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
145                 150                 155                 160 


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
                165                 170                 175     


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
            180                 185                 190         


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
        195                 200                 205             


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
    210                 215                 220                 


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
225                 230                 235                 240 


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
                245                 250                 255     


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
            260                 265                 270         


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
        275                 280                 285             


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
    290                 295                 300                 


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
305                 310                 315                 320 


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
                325                 330                 335     


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
            340                 345                 350         


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
        355                 360                 365             


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
    370                 375                 380                 


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
385                 390                 395                 400 


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
                405                 410                 415     


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
            420                 425                 430         


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
        435                 440                 445             


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
    450                 455                 460                 


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
465                 470                 475                 480 


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
                485                 490                 495     


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
            500                 505                 510         


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
        515                 520                 525             


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
    530                 535                 540                 


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
545                 550                 555                 560 


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
                565                 570                 575     


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
            580                 585                 590         


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
        595                 600                 605             


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
    610                 615                 620                 


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
625                 630                 635                 640 


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
                645                 650                 655     


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
            660                 665                 670         


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
        675                 680                 685             


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    690                 695                 700             


<210> 27
<211> 2052
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
atgtcacata taaaagggca tgaaggagac ccctgcctac gatcatcaga ctgcattgaa       60

gggttttgct gtgctcgtca tttctggacc aaaatctgca aaccagtgct ccatcagggg      120

gaagtctgta ccaaacaacg caagaagggt tctcatgggc tggaaatttt ccagcgttgc      180

gactgtgcga agggcctgtc ttgcaaagta tggaaagatg ccacctactc ctccaaagcc      240

agactccatg tgtgtcagaa aattggaggt gccagcaggg gtgtgtttcg tcgagatgca      300

cacaagagtg aggttgctca tcggtttaaa gatttgggag aagaaaattt caaagccttg      360

gtgttgattg cctttgctca gtatcttcag cagtgtccat ttgaagatca tgtaaaatta      420

gtgaatgaag taactgaatt tgcaaaaaca tgtgttgctg atgagtcagc tgaaaattgt      480

gacaaatcac ttcataccct ttttggagac aaattatgca cagttgcaac tcttcgtgaa      540

acctatggtg aaatggctga ctgctgtgca aaacaagaac ctgagagaaa tgaatgcttc      600

ttgcaacaca aagatgacaa cccaaacctc ccccgattgg tgagaccaga ggttgatgtg      660

atgtgcactg cttttcatga caatgaagag acatttttga aaaaatactt atatgaaatt      720

gccagaagac atccttactt ttatgccccg gaactccttt tctttgctaa aaggtataaa      780

gctgctttta cagaatgttg ccaagctgct gataaagctg cctgcctgtt gccaaagctc      840

gatgaacttc gggatgaagg gaaggcttcg tctgccaaac agagactcaa gtgtgccagt      900

ctccaaaaat ttggagaaag agctttcaaa gcatgggcag tagctcgcct gagccagaga      960

tttcccaaag ctgagtttgc agaagtttcc aagttagtga cagatcttac caaagtccac     1020

acggaatgct gccatggaga tctgcttgaa tgtgctgatg acagggcgga ccttgccaag     1080

tatatctgtg aaaatcaaga ttcgatctcc agtaaactga aggaatgctg tgaaaaacct     1140

ctgttggaaa aatcccactg cattgccgaa gtggaaaatg atgagatgcc tgctgacttg     1200

ccttcattag ctgctgattt tgttgaaagt aaggatgttt gcaaaaacta tgctgaggca     1260

aaggatgtct tcctgggcat gtttttgtat gaatatgcaa gaaggcatcc tgattactct     1320

gtcgtgctgc tgctgagact tgccaagaca tatgaaacca ctctagagaa gtgctgtgcc     1380

gctgcagatc ctcatgaatg ctatgccaaa gtgttcgatg aatttaaacc tcttgtggaa     1440

gagcctcaga atttaatcaa acaaaattgt gagctttttg agcagcttgg agagtacaaa     1500

ttccagaatg cgctattagt tcgttacacc aagaaagtac cccaagtgtc aactccaact     1560

cttgtagagg tctcaagaaa cctaggaaaa gtgggcagca aatgttgtaa acatcctgaa     1620

gcaaaaagaa tgccctgtgc agaagactat ctatccgtgg tcctgaacca gttatgtgtg     1680

ttgcatgaga aaacgccagt aagtgacaga gtcaccaaat gctgcacaga atccttggtg     1740

aacaggcgac catgcttttc agctctggaa gtcgatgaaa catacgttcc caaagagttt     1800

aatgctgaaa cattcacctt ccatgcagat atatgcacac tttctgagaa ggagagacaa     1860

atcaagaaac aaactgcact tgttgagctt gtgaaacaca agcccaaggc aacaaaagag     1920

caactgaaag ctgttatgga tgatttcgca gcttttgtag agaagtgctg caaggctgac     1980

gataaggaga cctgctttgc cgaggagggt aaaaaacttg ttgctgcaag tcaagctgcc     2040

ttaggcttat ga                                                         2052


<210> 28
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg 
            20                  25                  30          


Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr 
        35                  40                  45              


Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln 
    50                  55                  60                  


Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys 
65                  70                  75                  80  


Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser 
                85                  90                  95      


Lys Ala Arg Leu His Val Cys Gln Lys Ile Gly Ser Asp Ala His Lys 
            100                 105                 110         


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
        115                 120                 125             


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
    130                 135                 140                 


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
145                 150                 155                 160 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
                165                 170                 175     


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
            180                 185                 190         


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
        195                 200                 205             


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
    210                 215                 220                 


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
225                 230                 235                 240 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
                245                 250                 255     


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
            260                 265                 270         


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
        275                 280                 285             


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
    290                 295                 300                 


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
305                 310                 315                 320 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
                325                 330                 335     


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
            340                 345                 350         


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
        355                 360                 365             


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
    370                 375                 380                 


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
385                 390                 395                 400 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
                405                 410                 415     


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
            420                 425                 430         


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
        435                 440                 445             


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
    450                 455                 460                 


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
465                 470                 475                 480 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
                485                 490                 495     


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
            500                 505                 510         


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
        515                 520                 525             


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
    530                 535                 540                 


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
545                 550                 555                 560 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
                565                 570                 575     


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
            580                 585                 590         


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
        595                 600                 605             


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
    610                 615                 620                 


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
625                 630                 635                 640 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
                645                 650                 655     


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
            660                 665                 670         


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
        675                 680                 685             


Ala Ala Leu Gly Leu 
    690             


<210> 29
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 29
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

catataaaag ggcatgaagg agacccctgc ctacgatcat cagactgcat tgaagggttt      120

tgctgtgctc gtcatttctg gaccaaaatc tgcaaaccag tgctccatca gggggaagtc      180

tgtaccaaac aacgcaagaa gggttctcat gggctggaaa ttttccagcg ttgcgactgt      240

gcgaagggcc tgtcttgcaa agtatggaaa gatgccacct actcctccaa agccagactc      300

catgtgtgtc agaaaattgg atccgatgca cacaagagtg aggttgctca tcggtttaaa      360

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      420

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      480

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      540

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      600

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      660

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      720

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      780

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      840

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      900

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      960

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc     1020

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa     1080

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc     1140

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa     1200

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt     1260

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1320

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1380

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1440

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1500

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1560

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1620

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1680

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1740

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1800

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1860

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctt     1920

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1980

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     2040

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttat ga                        2082


<210> 30
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Asn Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 31
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Glu Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Glu Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 32
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Glu Val Trp Glu Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 33
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Glu Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 34
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Glu Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 35
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Asn Ser Ser Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 36
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Ser Gln Arg Lys Ser Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 37
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Ser Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


Thr Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 38
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Glu Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 39
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Glu His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 40
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Glu Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 41
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


Glu Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 42
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                645                 650                 655     


Glu Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 43
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Glu Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 44
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ala His Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His 
        595                 600                 605             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    610                 615                 620                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
625                 630                 635                 640 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Asn Gly Ser 
                645                 650                 655     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            660                 665                 670         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        675                 680                 685             


Val Cys Gln Lys Ile 
    690             


<210> 45
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 45
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccgaa caacgcaagg agggttctca tgggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgca aagtatggaa agatgccacc     2040

tactcctcca aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 46
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 46
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccgaa caacgcaaga agggttctca tgggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgca aagtatggaa agatgccacc     2040

tactcctccg aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 47
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 47
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccgaa caacgcaaga agggttctga agggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgca aagtatggaa agatgccacc     2040

tactcctcca aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 48
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 48
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccaaa caacgcaaga agggttctca tgggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgcg aagtatggga agatgccacc     2040

tactcctcca aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 49
<211> 2082
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg tgctcacgct       60

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa      120

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      180

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      240

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      300

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      360

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      420

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      480

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      540

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      600

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      660

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      720

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      780

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      840

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      900

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      960

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct     1020

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1080

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1140

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1200

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1260

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1320

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1380

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1440

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1500

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1560

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1620

agacaaatca agaaacaaac tgcacttgtt gagcttgtga aacacaagcc caaggcaaca     1680

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1740

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1800

gctgccttag gcttaggctc tcatataaaa gggcatgaag gagacccctg cctacgatca     1860

tcagactgca ttgaagggtt ttgctgtgct cgtcatttct ggaccaaaat ctgcaaacca     1920

gtgctccatc agggggaagt ctgtaccagc caacgcaaga gcggttctca tgggctggaa     1980

attttccagc gttgcgactg tgcgaagggc ctgtcttgca aagtatggaa agatgccacc     2040

tactcctcca aagccagact ccatgtgtgt cagaaaattt ga                        2082


<210> 50
<211> 585
<212> PRT
<213> Homo sapiens

<400> 50
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210> 51
<211> 86
<212> PRT
<213> Homo sapiens

<400> 51
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 52
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gly Gly Gly Ser 
1               


<210> 53
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Ser Gly Gly Gly 
1               


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gly Gly Gly Gly Ser 
1               5   


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Ser Gly Gly Gly Gly 
1               5   


<210> 56
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 57
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Ser Gly Gly Gly Gly Gly 
1               5       


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210> 60
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MISC_FEATURE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Xaa Xaa'
      repeating units" 

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Any amino acid

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 60
Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210> 61
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MISC_FEATURE
<222> (6)..(25)
<223> /note="This region may encompass 0-4 'Xaa Gly Gly Gly Ser'
      repeating units" 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Any amino acid

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 61
Gly Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa 
1               5                   10                  15      


Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
            20                  25  


<210> 62
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MISC_FEATURE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Pro Ser'
      repeating units" 

<400> 62
Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly 
1               5                   10                  15      


Gly Gly Pro Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 63
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MISC_FEATURE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Gly Gln'
      repeating units" 

<400> 63
Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
1               5                   10                  15      


Gly Gly Gly Gln Gly Gly Gly Gly Ser 
            20                  25  


<210> 64
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ser 
            20                  25  


<210> 65
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro 
1               5                   10                  15      


Gly Gly Gly Ser Pro Gly Gly Gly Ser 
            20                  25  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 68
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
1               5                   10                  15  


<210> 70
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Asn Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 71
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Glu His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 72
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 72
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Glu Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 73
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 73
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 74
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 74
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Ser Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 75
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 75
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Glu Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 76
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 76
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Asn Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 77
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser Glu Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 78
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Glu Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 79
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 79
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Glu Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 80
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Asn Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 81
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Glu Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 82
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Ser Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 83
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 83
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Glu Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Glu Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 84
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 84
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Glu Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 85
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 85
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Glu Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 86
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 86
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Glu Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser Glu Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 87
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Ser Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser Thr Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 88
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 88
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Glu Val Trp Glu Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 89
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 89
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Ser Gln Arg Lys Ser Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 90
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 90
His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys 
1               5                   10                  15      


Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys 
            20                  25                  30          


Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly 
        35                  40                  45              


Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu 
    50                  55                  60                  


Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Asn Ser Ser Ala Arg Leu 
65                  70                  75                  80  


His Val Cys Gln Lys Ile 
                85      


<210> 91
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 91
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln 
                245                 250                 255     


Ser Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser 
            260                 265                 270         


Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys 
        275                 280                 285             


Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg 
    290                 295                 300                 


Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala 
305                 310                 315                 320 


Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys 
                325                 330                 335     


Ala Arg Leu His Val Cys Gln Lys Ile 
            340                 345 


<210> 92
<211> 339
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 92
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu 
            20                  25                  30          


Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp 
        35                  40                  45              


Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys 
    50                  55                  60                  


Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp 
65                  70                  75                  80  


Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser 
                85                  90                  95      


Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile Glu Asn Leu Tyr Phe 
            100                 105                 110         


Gln Ser Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        115                 120                 125             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
145                 150                 155                 160 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                165                 170                 175     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            180                 185                 190         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        195                 200                 205             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                245                 250                 255     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            260                 265                 270         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        275                 280                 285             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    290                 295                 300                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
305                 310                 315                 320 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                325                 330                 335     


Ser Pro Gly 
            


<210> 93
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mating factor alpha 1 promoter sequence"

<400> 93
Ser Leu Asp Lys Arg 
1               5   


<210> 94
<211> 88
<212> PRT
<213> Homo sapiens

<400> 94
Met Pro His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys 
    50                  55                  60                  


Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala 
65                  70                  75                  80  


Arg Leu His Val Cys Gln Lys Ile 
                85              


<210> 95
<211> 88
<212> PRT
<213> Xenopus sp.

<400> 95
Ile Pro His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Thr 
1               5                   10                  15      


Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Leu Arg Lys 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys 
    50                  55                  60                  


Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ser 
65                  70                  75                  80  


Arg Leu His Ile Cys Gln Lys Ile 
                85              


<210> 96
<211> 89
<212> PRT
<213> Mus sp.

<400> 96
Ile Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ala Ala Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Lys Arg 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu 
    50                  55                  60                  


Gly Leu Ala Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn Ser 
65                  70                  75                  80  


Ser Arg Leu His Thr Cys Gln Arg His 
                85                  


<210> 97
<211> 89
<212> PRT
<213> Homo sapiens

<400> 97
Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg Arg 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu 
    50                  55                  60                  


Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn Ser 
65                  70                  75                  80  


Ser Arg Leu His Thr Cys Gln Arg His 
                85                  


<210> 98
<211> 89
<212> PRT
<213> Rattus sp.

<400> 98
Met Tyr His Ala Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ala Thr Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg Arg 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Asp 
    50                  55                  60                  


Gly Leu Ser Cys Arg Leu Gln Asn Asp Gln His Glu Ala Ser Asn Ser 
65                  70                  75                  80  


Ser Arg Leu His Thr Cys Gln Arg His 
                85                  


<210> 99
<211> 90
<212> PRT
<213> Xenopus sp.

<400> 99
Met Gln Pro Phe Lys Gly Arg Asp Gly Asp Val Cys Leu Arg Ser Thr 
1               5                   10                  15      


Asp Cys Ala Pro Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Asp Glu Gly Gln Val Cys Thr Lys His Arg Arg 
        35                  40                  45              


Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys His Cys Gly Ala 
    50                  55                  60                  


Gly Leu Ser Cys Arg Leu Gln Lys Gly Glu Phe Thr Thr Val Pro Lys 
65                  70                  75                  80  


Thr Ser Arg Leu His Thr Cys Gln Arg His 
                85                  90  


<210> 100
<211> 87
<212> PRT
<213> Danio rerio

<400> 100
Asn Gln Met Leu Lys Gly Leu Glu Gly Glu Asn Cys Leu Arg Ser Ser 
1               5                   10                  15      


Asp Cys Ala Glu Thr Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Lys Arg 
        35                  40                  45              


Lys Gly Thr His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Gly Glu 
    50                  55                  60                  


Gly Leu Ser Cys Arg Thr Gln Arg Gly Asp Gly Gly Lys Ala Ser Arg 
65                  70                  75                  80  


Ser Leu His Thr Cys Gln Arg 
                85          


<210> 101
<211> 88
<212> PRT
<213> Mus sp.

<400> 101
Ser Gln Ser Ser Lys Gly Gln Glu Gly Glu Ser Cys Leu Arg Thr Ser 
1               5                   10                  15      


Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Arg Glu Gly Gln Val Cys Ser Arg Arg Gly His 
        35                  40                  45              


Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln Arg Cys Asp Cys Gly 
    50                  55                  60                  


Pro Gly Leu Thr Cys Arg Ser Gln Val Thr Ser Asn Arg Gln His Ser 
65                  70                  75                  80  


Arg Leu Arg Val Cys Gln Arg Ile 
                85              


<210> 102
<211> 91
<212> PRT
<213> Homo sapiens

<400> 102
Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser Cys Leu Arg Thr Phe 
1               5                   10                  15      


Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His Phe Trp Thr Lys Ile 
            20                  25                  30          


Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys Ser Arg Arg Gly His 
        35                  40                  45              


Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln Arg Cys Asp Cys Gly 
    50                  55                  60                  


Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser Asn Arg Gln His Ala 
65                  70                  75                  80  


Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu 
                85                  90      


