                         SEQUENCE LISTING

<110>  Immunocore Limited
 
<120>  T cell receptors

<130>  P100579WO

<150>  1522592.3
<151>  2015-12-22

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  2
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
        195                 200                 205             


Glu Ser Ser 
    210     


<210>  3
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
        115                 120                 125             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
                165                 170                 175     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    210                 215                 220                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp 
                245 


<210>  4
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
        195                 200                 205             


Glu Ser Ser 
    210     


<210>  5
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
        115                 120                 125             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    210                 215                 220                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp 
                245 


<210>  6
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a12)

<400>  6

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ser 
                85                  90                  95      


Asp Gln His Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a24)

<400>  7

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a24l)

<400>  8

Ala Gln Ser Val Ala Gln Pro Glu Asp Leu Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a28)

<400>  9

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Ser Ser 
                85                  90                  95      


Arg Gln His Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a78l)

<400>  10

Ala Gln Ser Val Ala Gln Pro Glu Asp Leu Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asp Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a82l)

<400>  11

Ala Gln Ser Val Ala Gln Pro Glu Asp Leu Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Arg Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a82)

<400>  12

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Arg Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b5)

<400>  13

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b12)

<400>  14

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Leu Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  15
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b52)

<400>  15

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Leu Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  16
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b56)

<400>  16

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  17
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b56l)

<400>  17

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  18
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b65)

<400>  18

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Leu Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  19
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b65l)

<400>  19

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Leu Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  20
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b67)

<400>  20

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  21
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b67l)

<400>  21

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  22
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b68)

<400>  22

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  23
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b68l)

<400>  23

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  24

Gly Gly Gly Gly Ser 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  25

Gly Gly Gly Ser Gly 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  26

Gly Gly Ser Gly Gly 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  27

Gly Ser Gly Gly Gly 
1               5   


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  28

Gly Ser Gly Gly Gly Pro 
1               5       


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  29

Gly Gly Glu Pro Ser 
1               5   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  30

Gly Gly Glu Gly Gly Gly Pro 
1               5           


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  31

Gly Gly Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
1               5                   10          


<210>  32
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC alpha chain (comprising SEQ ID NO: 7(a24) and the constant
       domain of SEQ ID NO: 4, truncated by 8 amino acids)

<400>  32

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
        195                 200             


<210>  33
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC beta chain (comprising an anti-CD3 scFv fused via a
       linker to a TCR beta chain comprising SEQ ID NO: 15(b52) 
       and the constant domain of SEQ ID NO: 3)

<400>  33

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln 
            260                 265                 270         


Arg Gly Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala 
        275                 280                 285             


Leu Met Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile 
    290                 295                 300                 


Ala Thr Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val 
305                 310                 315                 320 


Ile Asp Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu 
                325                 330                 335     


Thr Val Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser 
            340                 345                 350         


Val Gly Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heteroclitic NY-ESO-1 peptide

<400>  34

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  35
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC alpha chain (comprising SEQ ID NO: 7(a24) and the constant
       domain of SEQ ID NO: 4, truncated by 8 amino acids)

<400>  35

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
        195                 200             


<210>  36
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC beta chain (comprising an anti-CD3 scFv fused via a linker
       to a TCR beta chain comprising SEQ ID NO: 18(b65) and the 
       constant domain of SEQ ID NO: 5)

<400>  36

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln 
            260                 265                 270         


Arg Gly Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala 
        275                 280                 285             


Leu Met Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile 
    290                 295                 300                 


Ala Thr Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val 
305                 310                 315                 320 


Ile Asp Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu 
                325                 330                 335     


Thr Val Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser 
            340                 345                 350         


Val Gly Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  37
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC alpha chain (comprising SEQ ID NO: 12(a82) and the 
       constant domain of SEQ ID NO: 4, truncated by 8 amino acids)

<400>  37

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Arg Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
        195                 200             


<210>  38
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC beta chain (comprising an anti-CD3 scFv fused via a linker
       to a TCR beta chain comprising SEQ ID NO: 15(b52) and the 
       constant domain of SEQ ID NO: 5)

<400>  38

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln 
            260                 265                 270         


Arg Gly Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala 
        275                 280                 285             


Leu Met Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile 
    290                 295                 300                 


Ala Thr Ala Trp Thr Gly Gly Glu Ala Thr Tyr Glu Ser Gly Phe Val 
305                 310                 315                 320 


Ile Asp Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu 
                325                 330                 335     


Thr Val Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser 
            340                 345                 350         


Val Gly Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  39
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC alpha chain (comprising SEQ ID NO: 12(a82) and the 
       constant domain of SEQ ID NO: 4, truncated by 8 amino acids)

<400>  39

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Gly Asp Ser Ala Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Arg Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
        195                 200             


<210>  40
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ImmTAC beta chain (comprising an anti-CD3 scFv fused via a linker
       to a TCR beta chain comprising SEQ ID NO: 18(b65) and the 
       constant domain of SEQ ID NO: 5)

<400>  40

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln 
            260                 265                 270         


Arg Gly Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Lys Arg Leu Ala 
        275                 280                 285             


Leu Met Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile 
    290                 295                 300                 


Ala Thr Ala Trp Thr Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val 
305                 310                 315                 320 


Ile Asp Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu 
                325                 330                 335     


Thr Val Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser 
            340                 345                 350         


Val Gly Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  43
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  43

Cys Ala Val Arg Asp Ile Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  44
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Gln Val Thr Met 
1               5   


<210>  45
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Asn Gln Gly Ser Glu Ala 
1               5           


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  46

Cys Ser Val Gly Gly Ser Gly Gly Ala Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  47
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
1               5                   10                  15      


Lys 
    


<210>  48
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Gly Ser Tyr Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser 
1               5                   10                  15      


Phe His Leu Lys Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr 
            20                  25                  30          


Phe 
    


<210>  49
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala 
1               5                   10                  15      


Thr 
    


<210>  50
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys Phe Pro Ile Ser Arg Pro 
1               5                   10                  15      


Asn Leu Thr Phe Ser Thr Leu Thr Val Ser Asn Met Ser Pro Glu Asp 
            20                  25                  30          


Ser Ser Ile Tyr Leu 
        35          


<210>  51
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a86)

<400>  51

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Leu Thr Asp Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Ile 
                85                  90                  95      


Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
            100                 105                 110         


Leu Ser Val Ile Pro 
        115         


<210>  52
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b71)

<400>  52

Ser Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Lys Gln Arg Gly 
1               5                   10                  15      


Thr Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Ala Met Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Gln Pro Gly Gln Ser Pro Thr Leu Ile Ala Thr 
        35                  40                  45              


Ala Trp Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp 
    50                  55                  60                  


Lys Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val 
65                  70                  75                  80  


Ser Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Gly 
                85                  90                  95      


Gly Ser Gly Ala Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


