                         SEQUENCE LISTING

<110>  Turun yliopisto
 
<120>  SECONDARY ANTIBODIES AGAINST IMMUNOCOMPLEXES COMPRISING 
       CYANOBACTERIAL CYCLIC PEPTIDE HEPATOTOXINS

<130>  2152161

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  1

Gly Gly Gly Gly Ser Gly Ala Gly Gly Ser Gly Gly Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is N, A, or Y

<400>  2

Arg Ala Ser Gln Ser Val Ser Ser Ser Xaa Leu Ala 
1               5                   10          


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  3

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Y, S, or M

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is S, Y, or H

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is T, Y, L

<400>  4

Gln Gln Xaa Xaa Ser Xaa Pro Trp Thr 
1               5                   


<210>  5
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51D1


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met His Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  6
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51F6


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56B8


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA59G2


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56E7


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  10
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51D12


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  11
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41B5


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA32C11


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA32F1


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA34G1


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA42E10


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  16
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA52C2


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met His Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  17
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA55D1


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51H4


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  19
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41A5


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met His Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  20
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA58A12


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  21
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA33D5


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41F2


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  23
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA52B4


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  24
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA57D4


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56D5


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA57A3


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA60A1


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA42A3


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(90)
<223>  CDR3

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  29
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA44E11


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  30
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51D1


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Thr Pro Tyr Asp Gly Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Trp Ser Ser Asn Trp Ile Tyr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51F6


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(108)
<223>  CDR3

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Trp Tyr Ser Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Phe Pro Trp Asp Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56B8


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(106)
<223>  CDR3

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Pro Tyr Gly Gly Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Arg Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA59G2


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(109)
<223>  CDR3

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Val Gly Gly Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Tyr Trp Gly Tyr Arg Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56E7


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(111)
<223>  CDR3

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Trp Pro Val Asp Gly Glu Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Tyr Gly Asn Ser Val Gly Arg Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51D12


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(111)
<223>  CDR3

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Asp Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Pro Tyr Leu Tyr Gly Ala Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41B5


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(109)
<223>  CDR3

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asn Pro Tyr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ala Gly Gln Gly Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA32C11


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(108)
<223>  CDR3

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asn Thr Ser Asn Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Trp Trp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA32F1


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  38

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Thr Asn Gly Gly Glu Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Val Thr Arg Pro Tyr Tyr Ala Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA34G1


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(108)
<223>  CDR3

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ile Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Trp Gly Tyr Pro Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA42E10


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(114)
<223>  CDR3

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Pro Tyr Thr Gly Thr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Asp Leu Ile Gly His Tyr Asp Val Tyr Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA52C2


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(107)
<223>  CDR3

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asp Pro Ser Asp Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Leu Asp Trp Pro Leu Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  42
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA55D1


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Tyr Asp Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Lys Gly Gly Tyr Arg Arg Ala Tyr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA51H4


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(108)
<223>  CDR3

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Trp Pro Tyr Asp Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Pro Glu Gly Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41A5


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(108)
<223>  CDR3

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asn Tyr Asp Gly Glu Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Phe Trp Tyr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA58A12


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(65)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (98)..(110)
<223>  CDR3

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Trp Pro Asn Asn Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Gln Trp Trp Tyr Gly Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA33D5


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(112)
<223>  CDR3

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asp Pro Asn Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ala Val Ser Trp Ser Val Val Val Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA41F2


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asp Tyr Val Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Tyr Ala His Gly Ile Ala Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA52B4


<220>
<221>  DISULFID
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DISULFID
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DISULFID
<222>  (99)..(110)
<223>  CDR3

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Trp Thr Asn Thr Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Trp Glu Trp Phe Ser Ile Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA57D4


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(106)
<223>  CDR3

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Asp Leu Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gly Trp Gly Asp Met Asp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  50
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA56D5


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(112)
<223>  CDR3

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Gly Asn Gly Gly Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Trp Phe Asp Ser Ser Tyr Lys His Arg Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  51
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA57A3


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(111)
<223>  CDR3

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Thr Tyr Asp Gly Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asn Pro Tyr Thr Arg Arg Arg Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA60A1


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(112)
<223>  CDR3

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Pro Tyr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Tyr Val Gly Ser Val Arg Thr Arg Val Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  53
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA42A3


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(104)
<223>  CDR3

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Tyr Asp Gly Glu Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Asp Gly Asp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  54
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone SA44E11


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(105)
<223>  CDR3

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Thr Tyr Asn Gly Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Pro Gly Asp Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


