                         SEQUENCE LISTING

<110>  SERVICIO ANDALUZ DE SALUD
 
<120>  Diagnstico del cncer de tejidos blandos

<130>  P12789PC00

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2725
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctcccagt ctctaagccg cggcgtctcc gcggccgaga ggccccagcg cccgcctccc       60

cggcccccgc ccccaccccc gcccccggct ctgcccacgc cctccgcccg ccagcccggc      120

agccagcgca gctccgggcc tcgctccctg tgcgtcctgc gggggcggag gcgcggagag      180

gcggcaagcg cagccgggga gggtgggggg gcagaggcac agacagaggc gcggaggctc      240

ggagagagaa gacgtggagg gagggacaga gcctggacag cggtggacac ggcatcgtgc      300

gcggggaaga gggcagcacg cagcaggcgc cgagcgccgg gcaccgagaa gggcagcccg      360

ggtgatctcc ggccgtccat gcacagagcg ccttccccca cagccgagca gccgccgggc      420

ggaggggaca gcgcccgccg gaccctgcag cccagactca agcccagtgc ccgagccatg      480

gcactgcctc ggacgctggg ggagctgcag ctgtaccggg tcctgcagcg cgccaacctc      540

ctttcctact atgagacctt catccagcag ggaggggacg acgtgcagca gctgtgtgag      600

gcgggtgagg aggagtttct ggagatcatg gcacttgtgg gcatggccac caagcccctc      660

catgtccggc gcctgcagaa ggcactgaga gagtgggcca ccaatccagg gctcttcagt      720

caaccagtgc ctgctgttcc cgtctccagc atcccgctct tcaagatctc tgagactgcg      780

ggtacccgga aagggagcat gagcaatggg catggcagcc caggggaaaa ggcaggcagt      840

gcccgcagtt ttagccccaa gagccccctt gaacttggag agaagctatc accactgcct      900

gggggacctg gggcagggga cccccggatc tggccaggcc ggagcactcc agagtcggac      960

gttggggcag gaggagaaga ggaggctggc tcgcccccct tctccccccc tgcaggggga     1020

ggagtccctg aggggactgg ggctgggggg ctggcagcag gtgggactgg gggtggtcca     1080

gaccgactgg agccagagat ggtacgcatg gtggtggaaa gtgtggagag gatcttccgg     1140

agcttcccaa ggggggatgc tggggaggtc acatccctgc taaagctgaa taagaagctg     1200

gcacggagcg ttgggcacat ctttgagatg gatgataatg acagccagaa ggaagaggag     1260

atccgcaaat acagcatcat ctatggccgt ttcgactcta agcggcggga gggcaagcag     1320

ctcagcctgc acgagctcac catcaacgag gctgctgccc agttctgcat gagggacaac     1380

acgctcttat tacggagagt ggagctcttc tctttgtccc gccaagtagc ccgagagagc     1440

acctacttgt cctccttgaa gggctccagg cttcaccctg aagaactggg aggccctcca     1500

ctgaagaagc tgaaacaaga ggttggagaa cagagtcacc ctgaaatcca gcagcctccc     1560

ccaggccctg agtcctatgt acccccatac cgccccagcc tggaggagga cagcgccagc     1620

ctgtctgggg agagtctgga tggacatttg caggctgtgg ggtcatgtcc aaggctgacg     1680

ccgccccctg ctgacctgcc tctggcattg ccagcccatg ggctatggag ccgacacatc     1740

ctgcagcaga cactgatgga cgaggggctg cggctcgccc gcctcgtctc ccacgaccgc     1800

gtgggccgcc tcagcccctg tgtgcctgcg aagccacctc tcgcagagtt cgaggaaggg     1860

ctgctggaca gatgtcctgc cccaggaccc catcccgcgc tggtggaggg tcgcaggagc     1920

agcgtgaaag tggaggctga ggccagccgg cagtgagggt tggactggtg tcttcagacc     1980

caggacctca gacttctggc tcacacagac ccccacgctc tccatccccg gaatctagtc     2040

acaaccctgg atccttcctc tgcccttctc ctgcctcccc acctgctcca tgggcataag     2100

actgtggggc ttcaagcaat aacaagcaga ggcctggaga gaggacacaa ggagggtgcg     2160

tggtgccctc acccctgccc agagcgaggg ggcaaggact ctgcctccag ggcatctggg     2220

gttttcccct ccctcacaca acacactccc attctcttta ggtttgcacc agtggtgtga     2280

gcagttggac tcagtttgga caagggggaa agggggactt ccctgggaag gtccagctaa     2340

aagtggcaac atttgccccc agaattgggg gcctgggaac actggacctg ctccttctcc     2400

cctctccttc cccgtttttg tgcttctggt ttgtttcttt aattaattta acaagtgctg     2460

cagtttgccc tcccattccc atctatcccc caagtccttt gcaatttctt ccctgcccta     2520

cataggggcg gtgggtgtgg gatcccttca ctggccccct cgggaggcct gggttggact     2580

cagggtctcc tccagctggg ggctggaccg cagcacctat ctgagcagtt agagcgtctt     2640

tcttttcaga ttgtgtacag tagattattt attttgttat tttggaataa aatttatttt     2700

atggcttagg aaaaaaaaaa aaaaa                                           2725


<210>  2
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Arg Ala Pro Ser Pro Thr Ala Glu Gln Pro Pro Gly Gly Gly 
1               5                   10                  15      


Asp Ser Ala Arg Arg Thr Leu Gln Pro Arg Leu Lys Pro Ser Ala Arg 
            20                  25                  30          


Ala Met Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg Val 
        35                  40                  45              


Leu Gln Arg Ala Asn Leu Leu Ser Tyr Tyr Glu Thr Phe Ile Gln Gln 
    50                  55                  60                  


Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu Phe 
65                  70                  75                  80  


Leu Glu Ile Met Ala Leu Val Gly Met Ala Thr Lys Pro Leu His Val 
                85                  90                  95      


Arg Arg Leu Gln Lys Ala Leu Arg Glu Trp Ala Thr Asn Pro Gly Leu 
            100                 105                 110         


Phe Ser Gln Pro Val Pro Ala Val Pro Val Ser Ser Ile Pro Leu Phe 
        115                 120                 125             


Lys Ile Ser Glu Thr Ala Gly Thr Arg Lys Gly Ser Met Ser Asn Gly 
    130                 135                 140                 


His Gly Ser Pro Gly Glu Lys Ala Gly Ser Ala Arg Ser Phe Ser Pro 
145                 150                 155                 160 


Lys Ser Pro Leu Glu Leu Gly Glu Lys Leu Ser Pro Leu Pro Gly Gly 
                165                 170                 175     


Pro Gly Ala Gly Asp Pro Arg Ile Trp Pro Gly Arg Ser Thr Pro Glu 
            180                 185                 190         


Ser Asp Val Gly Ala Gly Gly Glu Glu Glu Ala Gly Ser Pro Pro Phe 
        195                 200                 205             


Ser Pro Pro Ala Gly Gly Gly Val Pro Glu Gly Thr Gly Ala Gly Gly 
    210                 215                 220                 


Leu Ala Ala Gly Gly Thr Gly Gly Gly Pro Asp Arg Leu Glu Pro Glu 
225                 230                 235                 240 


Met Val Arg Met Val Val Glu Ser Val Glu Arg Ile Phe Arg Ser Phe 
                245                 250                 255     


Pro Arg Gly Asp Ala Gly Glu Val Thr Ser Leu Leu Lys Leu Asn Lys 
            260                 265                 270         


Lys Leu Ala Arg Ser Val Gly His Ile Phe Glu Met Asp Asp Asn Asp 
        275                 280                 285             


Ser Gln Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ile Ile Tyr Gly Arg 
    290                 295                 300                 


Phe Asp Ser Lys Arg Arg Glu Gly Lys Gln Leu Ser Leu His Glu Leu 
305                 310                 315                 320 


Thr Ile Asn Glu Ala Ala Ala Gln Phe Cys Met Arg Asp Asn Thr Leu 
                325                 330                 335     


Leu Leu Arg Arg Val Glu Leu Phe Ser Leu Ser Arg Gln Val Ala Arg 
            340                 345                 350         


Glu Ser Thr Tyr Leu Ser Ser Leu Lys Gly Ser Arg Leu His Pro Glu 
        355                 360                 365             


Glu Leu Gly Gly Pro Pro Leu Lys Lys Leu Lys Gln Glu Val Gly Glu 
    370                 375                 380                 


Gln Ser His Pro Glu Ile Gln Gln Pro Pro Pro Gly Pro Glu Ser Tyr 
385                 390                 395                 400 


Val Pro Pro Tyr Arg Pro Ser Leu Glu Glu Asp Ser Ala Ser Leu Ser 
                405                 410                 415     


Gly Glu Ser Leu Asp Gly His Leu Gln Ala Val Gly Ser Cys Pro Arg 
            420                 425                 430         


Leu Thr Pro Pro Pro Ala Asp Leu Pro Leu Ala Leu Pro Ala His Gly 
        435                 440                 445             


Leu Trp Ser Arg His Ile Leu Gln Gln Thr Leu Met Asp Glu Gly Leu 
    450                 455                 460                 


Arg Leu Ala Arg Leu Val Ser His Asp Arg Val Gly Arg Leu Ser Pro 
465                 470                 475                 480 


Cys Val Pro Ala Lys Pro Pro Leu Ala Glu Phe Glu Glu Gly Leu Leu 
                485                 490                 495     


Asp Arg Cys Pro Ala Pro Gly Pro His Pro Ala Leu Val Glu Gly Arg 
            500                 505                 510         


Arg Ser Ser Val Lys Val Glu Ala Glu Ala Ser Arg Gln 
        515                 520                 525 


<210>  3
<211>  2519
<212>  DNA
<213>  Homo sapiens

<400>  3
ctctcccagt ctctaagccg cggcgtctcc gcggccgaga ggccccagcg cccgcctccc       60

cggcccccgc ccccaccccc gcccccggct ctgcccacgc cctccgcccg ccagcccggc      120

agccagcgca gctccgggcc tcgctccctg tgcgtcctgc gggggcggag gcgcggagag      180

gcggcaagcg cagccgggga gggtgggggg gcagaggcac agacagaggc gcggaggctc      240

ggagagagaa gacgtggagg gagggacaga gcctggacag cggtggacac ggcatcgtgc      300

gcggggaaga gggcagcacg cagcaggcgc cgagcgccgg gcaccgagaa gggcagcccg      360

ggtgatctcc ggccgtccat gcacagagcg ccttccccca cagccgagca gccgccgggc      420

ggaggggaca gcgcccgccg gaccctgcag cccagactca agcccagtgc ccgagccatg      480

gcactgcctc ggacgctggg ggagctgcag ctgtaccggg tcctgcagcg cgccaacctc      540

ctttcctact atgagacctt catccagcag ggaggggacg acgtgcagca gctgtgtgag      600

gcgggtgagg aggagtttct ggagatcatg gcacttgtgg gcatggccac caagcccctc      660

catgtccggc gcctgcagaa ggcactgaga gagtgggcca ccaatccagg gctcttcagt      720

caaccagtgc ctgctgttcc cgtctccagc atcccgctct tcaagatctc tgagactgcg      780

ggtacccgga aagggagcat gagcaatggg catggcagcc caggggaaaa ggcaggcagt      840

gcccgcagtt ttagccccaa gagccccctt gaacttggag agaagctatc accactgcct      900

gggggacctg gggcagggga cccccggatc tggccaggcc ggagcactcc agagtcggac      960

gttggggcag gaggagaaga ggaggctggc tcgcccccct tctccccccc tgcaggggga     1020

ggagtccctg aggggactgg ggctgggggg ctggcagcag gtgggactgg gggtggtcca     1080

gaccgactgg agccagagat ggtacgcatg gtggtggaaa gtgtggagag gatcttccgg     1140

agcttcccaa ggggggatgc tggggaggtc acatccctgc taaagctgaa taagaagctg     1200

gcacggagcg ttgggcacat ctttgagatg gatgataatg acagccagaa ggaagaggag     1260

atccgcaaat acagcatcat ctatggccgt ttcgactcta agcggcggga gggcaagcag     1320

ctcagcctgc acgagctcac catcaacgag gctgctgccc agttctgcat gagggacaac     1380

acgctcttat tacggagagt ggagctcttc tctttgtccc gccaagtagc ccgagagagc     1440

acctacttgt cctccttgaa gggctccagg cttcaccctg aagaactggg aggccctcca     1500

ctgaagaagc tgaaacaaga ggttggagaa cagagtcacc ctgaaatcca gcagcctccc     1560

ccaggccctg agtcctatgt acccccatac cgccccagcc tggaggagga cagcgccagc     1620

ctgtctgggg agagtctgga tggacatttg caggagttcg aggaagggct gctggacaga     1680

tgtcctgccc caggacccca tcccgcgctg gtggagggtc gcaggagcag cgtgaaagtg     1740

gaggctgagg ccagccggca gtgagggttg gactggtgtc ttcagaccca ggacctcaga     1800

cttctggctc acacagaccc ccacgctctc catccccgga atctagtcac aaccctggat     1860

ccttcctctg cccttctcct gcctccccac ctgctccatg ggcataagac tgtggggctt     1920

caagcaataa caagcagagg cctggagaga ggacacaagg agggtgcgtg gtgccctcac     1980

ccctgcccag agcgaggggg caaggactct gcctccaggg catctggggt tttcccctcc     2040

ctcacacaac acactcccat tctctttagg tttgcaccag tggtgtgagc agttggactc     2100

agtttggaca agggggaaag ggggacttcc ctgggaaggt ccagctaaaa gtggcaacat     2160

ttgcccccag aattgggggc ctgggaacac tggacctgct ccttctcccc tctccttccc     2220

cgtttttgtg cttctggttt gtttctttaa ttaatttaac aagtgctgca gtttgccctc     2280

ccattcccat ctatccccca agtcctttgc aatttcttcc ctgccctaca taggggcggt     2340

gggtgtggga tcccttcact ggccccctcg ggaggcctgg gttggactca gggtctcctc     2400

cagctggggg ctggaccgca gcacctatct gagcagttag agcgtctttc ttttcagatt     2460

gtgtacagta gattatttat tttgttattt tggaataaaa tttattttat ggcttagga      2519


<210>  4
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Arg Ala Pro Ser Pro Thr Ala Glu Gln Pro Pro Gly Gly Gly 
1               5                   10                  15      


Asp Ser Ala Arg Arg Thr Leu Gln Pro Arg Leu Lys Pro Ser Ala Arg 
            20                  25                  30          


Ala Met Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg Val 
        35                  40                  45              


Leu Gln Arg Ala Asn Leu Leu Ser Tyr Tyr Glu Thr Phe Ile Gln Gln 
    50                  55                  60                  


Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu Phe 
65                  70                  75                  80  


Leu Glu Ile Met Ala Leu Val Gly Met Ala Thr Lys Pro Leu His Val 
                85                  90                  95      


Arg Arg Leu Gln Lys Ala Leu Arg Glu Trp Ala Thr Asn Pro Gly Leu 
            100                 105                 110         


Phe Ser Gln Pro Val Pro Ala Val Pro Val Ser Ser Ile Pro Leu Phe 
        115                 120                 125             


Lys Ile Ser Glu Thr Ala Gly Thr Arg Lys Gly Ser Met Ser Asn Gly 
    130                 135                 140                 


His Gly Ser Pro Gly Glu Lys Ala Gly Ser Ala Arg Ser Phe Ser Pro 
145                 150                 155                 160 


Lys Ser Pro Leu Glu Leu Gly Glu Lys Leu Ser Pro Leu Pro Gly Gly 
                165                 170                 175     


Pro Gly Ala Gly Asp Pro Arg Ile Trp Pro Gly Arg Ser Thr Pro Glu 
            180                 185                 190         


Ser Asp Val Gly Ala Gly Gly Glu Glu Glu Ala Gly Ser Pro Pro Phe 
        195                 200                 205             


Ser Pro Pro Ala Gly Gly Gly Val Pro Glu Gly Thr Gly Ala Gly Gly 
    210                 215                 220                 


Leu Ala Ala Gly Gly Thr Gly Gly Gly Pro Asp Arg Leu Glu Pro Glu 
225                 230                 235                 240 


Met Val Arg Met Val Val Glu Ser Val Glu Arg Ile Phe Arg Ser Phe 
                245                 250                 255     


Pro Arg Gly Asp Ala Gly Glu Val Thr Ser Leu Leu Lys Leu Asn Lys 
            260                 265                 270         


Lys Leu Ala Arg Ser Val Gly His Ile Phe Glu Met Asp Asp Asn Asp 
        275                 280                 285             


Ser Gln Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ile Ile Tyr Gly Arg 
    290                 295                 300                 


Phe Asp Ser Lys Arg Arg Glu Gly Lys Gln Leu Ser Leu His Glu Leu 
305                 310                 315                 320 


Thr Ile Asn Glu Ala Ala Ala Gln Phe Cys Met Arg Asp Asn Thr Leu 
                325                 330                 335     


Leu Leu Arg Arg Val Glu Leu Phe Ser Leu Ser Arg Gln Val Ala Arg 
            340                 345                 350         


Glu Ser Thr Tyr Leu Ser Ser Leu Lys Gly Ser Arg Leu His Pro Glu 
        355                 360                 365             


Glu Leu Gly Gly Pro Pro Leu Lys Lys Leu Lys Gln Glu Val Gly Glu 
    370                 375                 380                 


Gln Ser His Pro Glu Ile Gln Gln Pro Pro Pro Gly Pro Glu Ser Tyr 
385                 390                 395                 400 


Val Pro Pro Tyr Arg Pro Ser Leu Glu Glu Asp Ser Ala Ser Leu Ser 
                405                 410                 415     


Gly Glu Ser Leu Asp Gly His Leu Gln Glu Phe Glu Glu Gly Leu Leu 
            420                 425                 430         


Asp Arg Cys Pro Ala Pro Gly Pro His Pro Ala Leu Val Glu Gly Arg 
        435                 440                 445             


Arg Ser Ser Val Lys Val Glu Ala Glu Ala Ser Arg Gln 
    450                 455                 460     


<210>  5
<211>  3755
<212>  DNA
<213>  Homo sapiens

<400>  5
agagctccag ggagggacct gggtagaagg agaagccgga aacagcgggc tggggcagcc       60

actgcttaca ctgaagaggg aggacgggag aggagtgtgt gtgtgtgtgt gtgtgtgtgt      120

gtgtatgtat gtgtgtgctt tatcttattt ttctttttgg tggtggtggt ggaagggggg      180

aggtgctagc agggccagcc ttgaactcgc tggacagagc tacagaccta tggggcctgg      240

aagtgcccgc tgagaaaggg agaagacagc agaggggttg ccgagagcat atatcagagg      300

gaccccctga agctggtggc cactttcaga caaatacttc aaggagagaa aaaagctgtt      360

atggaacagt tccgccactt gccaatgcct ttccactgga agcaggaaga actcaagttt      420

aagacaggct tgcggaggct gcagcaccga gtaggggaga tccaccttct ccgagaagcc      480

ctgcagaagg gggctgaggc tggccaagtg tctctgcaca gcttgataga aactcctgct      540

aatgggactg ggccaagtga ggccctggcc atgctactgc aggagaccac tggagagcta      600

gaggcagcca aagccctagt gctgaagagg atccagattt ggaaacggca gcagcagctg      660

gcagggaatg gcgcaccgtt tgaggagagc ctggccccac tccaggagag gtgtgaaagc      720

ctggtggaca tttattccca gctacagcag gaggtagggg cggctggtgg ggagcttgag      780

cccaagaccc gggcatcgct gactggccgg ctggatgaag tcctgagaac cctcgtcacc      840

agttgcttcc tggtggagaa gcagcccccc caggtactga agactcagac caagttccag      900

gctggagttc gattcctgtt gggcttgagg ttcctggggg ccccagccaa gcctccgctg      960

gtcagggccg acatggtgac agagaagcag gcgcgggagc tgagtgtgcc tcagggtcct     1020

ggggctggag cagaaagcac tggagaaatc atcaacaaca ctgtgccctt ggagaacagc     1080

attcctggga actgctgctc tgccctgttc aagaacctgc ttctcaagaa gatcaagcgg     1140

tgtgagcgga agggcactga gtctgtcaca gaggagaagt gcgctgtgct cttctctgcc     1200

agcttcacac ttggccccgg caaactcccc atccagctcc aggccctgtc tctgcccctg     1260

gtggtcatcg tccatggcaa ccaagacaac aatgccaaag ccactatcct gtgggacaat     1320

gccttctctg agatggaccg cgtgcccttt gtggtggctg agcgggtgcc ctgggagaag     1380

atgtgtgaaa ctctgaacct gaagttcatg gctgaggtgg ggaccaaccg ggggctgctc     1440

ccagagcact tcctcttcct ggcccagaag atcttcaatg acaacagcct cagtatggag     1500

gccttccagc accgttctgt gtcctggtcg cagttcaaca aggagatcct gctgggccgt     1560

ggcttcacct tttggcagtg gtttgatggt gtcctggacc tcaccaaacg ctgtctccgg     1620

agctactggt ctgaccggct gatcattggc ttcatcagca aacagtacgt tactagcctt     1680

cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc     1740

atcaccattg cccatgtcat ccggggccag gatggctctc cacagataga gaacatccag     1800

ccattctctg ccaaagacct gtccattcgc tcactggggg accgaatccg ggatcttgct     1860

cagctcaaaa atctctatcc caagaagccc aaggatgagg ctttccggag ccactacaag     1920

cctgaacaga tgggtaagga tggcaggggt tatgtcccag ctaccatcaa gatgaccgtg     1980

gaaagggacc aaccacttcc taccccagag ctccagatgc ctaccatggt gccttcttat     2040

gaccttggaa tggcccctga ttcctccatg agcatgcagc ttggcccaga tatggtgccc     2100

caggtgtacc caccacactc tcactccatc cccccgtatc aaggcctctc cccagaagaa     2160

tcagtcaacg tgttgtcagc cttccaggag cctcacctgc agatgccccc cagcctgggc     2220

cagatgagcc tgccctttga ccagcctcac ccccagggcc tgctgccgtg ccagcctcag     2280

gagcatgctg tgtccagccc tgaccccctg ctctgctcag atgtgaccat ggtggaagac     2340

agctgcctga gccagccagt gacagcgttt cctcagggca cttggattgg tgaagacata     2400

ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct ggaggggcaa     2460

ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc ccactatggg     2520

caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg gtgatcccag     2580

ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg ctctggacac     2640

ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc acctactcct     2700

gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat ccactccttc     2760

ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa gttcaggctc     2820

tgagacacac cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca cacacataca     2880

gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc acaggttagg     2940

gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg caggaacata     3000

cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc ctaggggaat     3060

gggaagcagc tcaagggacc ctgggtggga gcataggagg ggtctggaca tgtggttact     3120

agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg ttagccaggt     3180

ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga ttcttcgtgt     3240

atagctgtgt gaacgtgtat gtacctagga tatgttaaat gtatagctgg caccttagtt     3300

gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca caaatttggg     3360

agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga catatgctaa     3420

cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag tggctgtgac     3480

atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga gtctgggtcc     3540

aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca tcttttctgt     3600

tgccccatcc accgccagct tcccttcact cccctatccc attctccctc tcaaggcagg     3660

ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat aaataatcta     3720

ctgtacacaa tctgaaaaga aaaaaaaaaa aaaaa                                3755


<210>  6
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu 
1               5                   10                  15      


Glu Leu Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly 
            20                  25                  30          


Glu Ile His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly 
        35                  40                  45              


Gln Val Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly 
    50                  55                  60                  


Pro Ser Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu 
65                  70                  75                  80  


Glu Ala Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg 
                85                  90                  95      


Gln Gln Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala 
            100                 105                 110         


Pro Leu Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu 
        115                 120                 125             


Gln Gln Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg 
    130                 135                 140                 


Ala Ser Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr 
145                 150                 155                 160 


Ser Cys Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln 
                165                 170                 175     


Thr Lys Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu 
            180                 185                 190         


Gly Ala Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu 
        195                 200                 205             


Lys Gln Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala 
    210                 215                 220                 


Glu Ser Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser 
225                 230                 235                 240 


Ile Pro Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys 
                245                 250                 255     


Lys Ile Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu 
            260                 265                 270         


Lys Cys Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys 
        275                 280                 285             


Leu Pro Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val 
    290                 295                 300                 


His Gly Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn 
305                 310                 315                 320 


Ala Phe Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val 
                325                 330                 335     


Pro Trp Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu 
            340                 345                 350         


Val Gly Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala 
        355                 360                 365             


Gln Lys Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His 
    370                 375                 380                 


Arg Ser Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg 
385                 390                 395                 400 


Gly Phe Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys 
                405                 410                 415     


Arg Cys Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile 
            420                 425                 430         


Ser Lys Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr 
        435                 440                 445             


Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala 
    450                 455                 460                 


His Val Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln 
465                 470                 475                 480 


Pro Phe Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile 
                485                 490                 495     


Arg Asp Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp 
            500                 505                 510         


Glu Ala Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly 
        515                 520                 525             


Arg Gly Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln 
    530                 535                 540                 


Pro Leu Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr 
545                 550                 555                 560 


Asp Leu Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro 
                565                 570                 575     


Asp Met Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro 
            580                 585                 590         


Tyr Gln Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe 
        595                 600                 605             


Gln Glu Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu 
    610                 615                 620                 


Pro Phe Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln 
625                 630                 635                 640 


Glu His Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr 
                645                 650                 655     


Met Val Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln 
            660                 665                 670         


Gly Thr Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr 
        675                 680                 685             


Glu Gln Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly 
    690                 695                 700                 


Gly Gly Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly 
705                 710                 715                 720 


Gln Ser Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser 
                725                 730                 735     


Trp 
    


<210>  7
<211>  3894
<212>  DNA
<213>  Homo sapiens

<400>  7
agagctccag ggagggacct gggtagaagg agaagccgga aacagcgggc tggggcagcc       60

actgcttaca ctgaagaggg aggacgggag aggagtgtgt gtgtgtgtgt gtgtgtgtgt      120

gtgtatgtat gtgtgtgctt tatcttattt ttctttttgg tggtggtggt ggaagggggg      180

aggtgctagc agggccagcc ttgaactcgc tggacagagc tacagaccta tggggcctgg      240

aagtgcccgc tgagaaaggg agaagacagc agaggggttg ccgagggagt tcctggtcgg      300

ctccgacgcc ttctgctgca acttggctag tgccctactt tcagacactg tccagcacct      360

tcaggcctcg gtgggagagc agggggaggg gagcaccatc ttgcaacaca tcagcaccct      420

tgagagcata tatcagaggg accccctgaa gctggtggcc actttcagac aaatacttca      480

aggagagaaa aaagctgtta tggaacagtt ccgccacttg ccaatgcctt tccactggaa      540

gcaggaagaa ctcaagttta agacaggctt gcggaggctg cagcaccgag taggggagat      600

ccaccttctc cgagaagccc tgcagaaggg ggctgaggct ggccaagtgt ctctgcacag      660

cttgatagaa actcctgcta atgggactgg gccaagtgag gccctggcca tgctactgca      720

ggagaccact ggagagctag aggcagccaa agccctagtg ctgaagagga tccagatttg      780

gaaacggcag cagcagctgg cagggaatgg cgcaccgttt gaggagagcc tggccccact      840

ccaggagagg tgtgaaagcc tggtggacat ttattcccag ctacagcagg aggtaggggc      900

ggctggtggg gagcttgagc ccaagacccg ggcatcgctg actggccggc tggatgaagt      960

cctgagaacc ctcgtcacca gttgcttcct ggtggagaag cagccccccc aggtactgaa     1020

gactcagacc aagttccagg ctggagttcg attcctgttg ggcttgaggt tcctgggggc     1080

cccagccaag cctccgctgg tcagggccga catggtgaca gagaagcagg cgcgggagct     1140

gagtgtgcct cagggtcctg gggctggagc agaaagcact ggagaaatca tcaacaacac     1200

tgtgcccttg gagaacagca ttcctgggaa ctgctgctct gccctgttca agaacctgct     1260

tctcaagaag atcaagcggt gtgagcggaa gggcactgag tctgtcacag aggagaagtg     1320

cgctgtgctc ttctctgcca gcttcacact tggccccggc aaactcccca tccagctcca     1380

ggccctgtct ctgcccctgg tggtcatcgt ccatggcaac caagacaaca atgccaaagc     1440

cactatcctg tgggacaatg ccttctctga gatggaccgc gtgccctttg tggtggctga     1500

gcgggtgccc tgggagaaga tgtgtgaaac tctgaacctg aagttcatgg ctgaggtggg     1560

gaccaaccgg gggctgctcc cagagcactt cctcttcctg gcccagaaga tcttcaatga     1620

caacagcctc agtatggagg ccttccagca ccgttctgtg tcctggtcgc agttcaacaa     1680

ggagatcctg ctgggccgtg gcttcacctt ttggcagtgg tttgatggtg tcctggacct     1740

caccaaacgc tgtctccgga gctactggtc tgaccggctg atcattggct tcatcagcaa     1800

acagtacgtt actagccttc ttctcaatga gcccgacgga acctttctcc tccgcttcag     1860

cgactcagag attgggggca tcaccattgc ccatgtcatc cggggccagg atggctctcc     1920

acagatagag aacatccagc cattctctgc caaagacctg tccattcgct cactggggga     1980

ccgaatccgg gatcttgctc agctcaaaaa tctctatccc aagaagccca aggatgaggc     2040

tttccggagc cactacaagc ctgaacagat gggtaaggat ggcaggggtt atgtcccagc     2100

taccatcaag atgaccgtgg aaagggacca accacttcct accccagagc tccagatgcc     2160

taccatggtg ccttcttatg accttggaat ggcccctgat tcctccatga gcatgcagct     2220

tggcccagat atggtgcccc aggtgtaccc accacactct cactccatcc ccccgtatca     2280

aggcctctcc ccagaagaat cagtcaacgt gttgtcagcc ttccaggagc ctcacctgca     2340

gatgcccccc agcctgggcc agatgagcct gccctttgac cagcctcacc cccagggcct     2400

gctgccgtgc cagcctcagg agcatgctgt gtccagccct gaccccctgc tctgctcaga     2460

tgtgaccatg gtggaagaca gctgcctgag ccagccagtg acagcgtttc ctcagggcac     2520

ttggattggt gaagacatat tccctcctct gctgcctccc actgaacagg acctcactaa     2580

gcttctcctg gaggggcaag gggagtcggg gggagggtcc ttgggggcac agcccctcct     2640

gcagccctcc cactatgggc aatctgggat ctcaatgtcc cacatggacc taagggccaa     2700

ccccagttgg tgatcccagc tggagggaga acccaaagag acagctcttc tactaccccc     2760

acagacctgc tctggacact tgctcatgcc ctgccaagca gcagatgggg agggtgccct     2820

cctatcccca cctactcctg ggtcaggagg aaaagactaa caggagaatg cacagtgggt     2880

ggagccaatc cactccttcc tttctatcat tcccctgccc acctccttcc agcactgact     2940

ggaagggaag ttcaggctct gagacacacc ccaacatgcc tgcacctgca gcgcgcacac     3000

gcacgcacac acacatacag agctctctga gggtgatggg gctgagcagg aggggggctg     3060

ggtaagagca caggttaggg catggaaggc ttctccgccc attctgaccc agggcctagg     3120

acggataggc aggaacatac agacacattt acactagagg ccagggatag aggatattgg     3180

gtctcagccc taggggaatg ggaagcagct caagggaccc tgggtgggag cataggaggg     3240

gtctggacat gtggttacta gtacaggttt tgccctgatt aaaaaatctc ccaaagcccc     3300

aaattcctgt tagccaggtg gaggcttctg atacgtgtat gagactatgc aaaagtacaa     3360

gggctgagat tcttcgtgta tagctgtgtg aacgtgtatg tacctaggat atgttaaatg     3420

tatagctggc accttagttg catgaccaca tagaacatgt gtctatctgc ttttgcctac     3480

gtgacaacac aaatttggga gggtgagaca ctgcacagaa gacagcagca agtgtgctgg     3540

cctctctgac atatgctaac ccccaaatac tctgaatttg gagtctgact gtgcccaagt     3600

gggtccaagt ggctgtgaca tctacgtatg gctccacacc tccaatgctg cctgggagcc     3660

agggtgagag tctgggtcca ggcctggcca tgtggccctc cagtgtatga gagggccctg     3720

cctgctgcat cttttctgtt gccccatcca ccgccagctt cccttcactc ccctatccca     3780

ttctccctct caaggcaggg gtcatagatc ctaagccata aaataaattt tattccaaaa     3840

taacaaaata aataatctac tgtacacaat ctgaaaagaa aaaaaaaaaa aaaa           3894


<210>  8
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu 
1               5                   10                  15      


Glu Leu Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly 
            20                  25                  30          


Glu Ile His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly 
        35                  40                  45              


Gln Val Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly 
    50                  55                  60                  


Pro Ser Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu 
65                  70                  75                  80  


Glu Ala Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg 
                85                  90                  95      


Gln Gln Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala 
            100                 105                 110         


Pro Leu Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu 
        115                 120                 125             


Gln Gln Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg 
    130                 135                 140                 


Ala Ser Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr 
145                 150                 155                 160 


Ser Cys Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln 
                165                 170                 175     


Thr Lys Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu 
            180                 185                 190         


Gly Ala Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu 
        195                 200                 205             


Lys Gln Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala 
    210                 215                 220                 


Glu Ser Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser 
225                 230                 235                 240 


Ile Pro Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys 
                245                 250                 255     


Lys Ile Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu 
            260                 265                 270         


Lys Cys Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys 
        275                 280                 285             


Leu Pro Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val 
    290                 295                 300                 


His Gly Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn 
305                 310                 315                 320 


Ala Phe Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val 
                325                 330                 335     


Pro Trp Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu 
            340                 345                 350         


Val Gly Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala 
        355                 360                 365             


Gln Lys Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His 
    370                 375                 380                 


Arg Ser Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg 
385                 390                 395                 400 


Gly Phe Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys 
                405                 410                 415     


Arg Cys Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile 
            420                 425                 430         


Ser Lys Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr 
        435                 440                 445             


Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala 
    450                 455                 460                 


His Val Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln 
465                 470                 475                 480 


Pro Phe Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile 
                485                 490                 495     


Arg Asp Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp 
            500                 505                 510         


Glu Ala Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly 
        515                 520                 525             


Arg Gly Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln 
    530                 535                 540                 


Pro Leu Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr 
545                 550                 555                 560 


Asp Leu Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro 
                565                 570                 575     


Asp Met Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro 
            580                 585                 590         


Tyr Gln Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe 
        595                 600                 605             


Gln Glu Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu 
    610                 615                 620                 


Pro Phe Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln 
625                 630                 635                 640 


Glu His Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr 
                645                 650                 655     


Met Val Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln 
            660                 665                 670         


Gly Thr Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr 
        675                 680                 685             


Glu Gln Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly 
    690                 695                 700                 


Gly Gly Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly 
705                 710                 715                 720 


Gln Ser Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser 
                725                 730                 735     


Trp 
    


<210>  9
<211>  4031
<212>  DNA
<213>  Homo sapiens

<400>  9
agagctccag ggagggacct gggtagaagg agaagccgga aacagcgggc tggggcagcc       60

actgcttaca ctgaagaggg aggacgggag aggagtgtgt gtgtgtgtgt gtgtgtgtgt      120

gtgtatgtat gtgtgtgctt tatcttattt ttctttttgg tggtggtggt ggaagggggg      180

aggtgctagc agggccagcc ttgaactcgc tggacagagc tacagaccta tggggcctgg      240

aagtgcccgc tgagaaaggg agaagacagc agaggggttg ccgaggcaac ctccaagtcc      300

cagatcatgt ctctgtgggg tctggtctcc aagatgcccc cagaaaaagt gcagcggctc      360

tatgtcgact ttccccaaca cctgcggcat cttctgggtg actggctgga gagccagccc      420

tgggagttcc tggtcggctc cgacgccttc tgctgcaact tggctagtgc cctactttca      480

gacactgtcc agcaccttca ggcctcggtg ggagagcagg gggaggggag caccatcttg      540

caacacatca gcacccttga gagcatatat cagagggacc ccctgaagct ggtggccact      600

ttcagacaaa tacttcaagg agagaaaaaa gctgttatgg aacagttccg ccacttgcca      660

atgcctttcc actggaagca ggaagaactc aagtttaaga caggcttgcg gaggctgcag      720

caccgagtag gggagatcca ccttctccga gaagccctgc agaagggggc tgaggctggc      780

caagtgtctc tgcacagctt gatagaaact cctgctaatg ggactgggcc aagtgaggcc      840

ctggccatgc tactgcagga gaccactgga gagctagagg cagccaaagc cctagtgctg      900

aagaggatcc agatttggaa acggcagcag cagctggcag ggaatggcgc accgtttgag      960

gagagcctgg ccccactcca ggagaggtgt gaaagcctgg tggacattta ttcccagcta     1020

cagcaggagg taggggcggc tggtggggag cttgagccca agacccgggc atcgctgact     1080

ggccggctgg atgaagtcct gagaaccctc gtcaccagtt gcttcctggt ggagaagcag     1140

cccccccagg tactgaagac tcagaccaag ttccaggctg gagttcgatt cctgttgggc     1200

ttgaggttcc tgggggcccc agccaagcct ccgctggtca gggccgacat ggtgacagag     1260

aagcaggcgc gggagctgag tgtgcctcag ggtcctgggg ctggagcaga aagcactgga     1320

gaaatcatca acaacactgt gcccttggag aacagcattc ctgggaactg ctgctctgcc     1380

ctgttcaaga acctgcttct caagaagatc aagcggtgtg agcggaaggg cactgagtct     1440

gtcacagagg agaagtgcgc tgtgctcttc tctgccagct tcacacttgg ccccggcaaa     1500

ctccccatcc agctccaggc cctgtctctg cccctggtgg tcatcgtcca tggcaaccaa     1560

gacaacaatg ccaaagccac tatcctgtgg gacaatgcct tctctgagat ggaccgcgtg     1620

ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag     1680

ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc     1740

cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc     1800

tggtcgcagt tcaacaagga gatcctgctg ggccgtggct tcaccttttg gcagtggttt     1860

gatggtgtcc tggacctcac caaacgctgt ctccggagct actggtctga ccggctgatc     1920

attggcttca tcagcaaaca gtacgttact agccttcttc tcaatgagcc cgacggaacc     1980

tttctcctcc gcttcagcga ctcagagatt gggggcatca ccattgccca tgtcatccgg     2040

ggccaggatg gctctccaca gatagagaac atccagccat tctctgccaa agacctgtcc     2100

attcgctcac tgggggaccg aatccgggat cttgctcagc tcaaaaatct ctatcccaag     2160

aagcccaagg atgaggcttt ccggagccac tacaagcctg aacagatggg taaggatggc     2220

aggggttatg tcccagctac catcaagatg accgtggaaa gggaccaacc acttcctacc     2280

ccagagctcc agatgcctac catggtgcct tcttatgacc ttggaatggc ccctgattcc     2340

tccatgagca tgcagcttgg cccagatatg gtgccccagg tgtacccacc acactctcac     2400

tccatccccc cgtatcaagg cctctcccca gaagaatcag tcaacgtgtt gtcagccttc     2460

caggagcctc acctgcagat gccccccagc ctgggccaga tgagcctgcc ctttgaccag     2520

cctcaccccc agggcctgct gccgtgccag cctcaggagc atgctgtgtc cagccctgac     2580

cccctgctct gctcagatgt gaccatggtg gaagacagct gcctgagcca gccagtgaca     2640

gcgtttcctc agggcacttg gattggtgaa gacatattcc ctcctctgct gcctcccact     2700

gaacaggacc tcactaagct tctcctggag gggcaagggg agtcgggggg agggtccttg     2760

ggggcacagc ccctcctgca gccctcccac tatgggcaat ctgggatctc aatgtcccac     2820

atggacctaa gggccaaccc cagttggtga tcccagctgg agggagaacc caaagagaca     2880

gctcttctac tacccccaca gacctgctct ggacacttgc tcatgccctg ccaagcagca     2940

gatggggagg gtgccctcct atccccacct actcctgggt caggaggaaa agactaacag     3000

gagaatgcac agtgggtgga gccaatccac tccttccttt ctatcattcc cctgcccacc     3060

tccttccagc actgactgga agggaagttc aggctctgag acacacccca acatgcctgc     3120

acctgcagcg cgcacacgca cgcacacaca catacagagc tctctgaggg tgatggggct     3180

gagcaggagg ggggctgggt aagagcacag gttagggcat ggaaggcttc tccgcccatt     3240

ctgacccagg gcctaggacg gataggcagg aacatacaga cacatttaca ctagaggcca     3300

gggatagagg atattgggtc tcagccctag gggaatggga agcagctcaa gggaccctgg     3360

gtgggagcat aggaggggtc tggacatgtg gttactagta caggttttgc cctgattaaa     3420

aaatctccca aagccccaaa ttcctgttag ccaggtggag gcttctgata cgtgtatgag     3480

actatgcaaa agtacaaggg ctgagattct tcgtgtatag ctgtgtgaac gtgtatgtac     3540

ctaggatatg ttaaatgtat agctggcacc ttagttgcat gaccacatag aacatgtgtc     3600

tatctgcttt tgcctacgtg acaacacaaa tttgggaggg tgagacactg cacagaagac     3660

agcagcaagt gtgctggcct ctctgacata tgctaacccc caaatactct gaatttggag     3720

tctgactgtg cccaagtggg tccaagtggc tgtgacatct acgtatggct ccacacctcc     3780

aatgctgcct gggagccagg gtgagagtct gggtccaggc ctggccatgt ggccctccag     3840

tgtatgagag ggccctgcct gctgcatctt ttctgttgcc ccatccaccg ccagcttccc     3900

ttcactcccc tatcccattc tccctctcaa ggcaggggtc atagatccta agccataaaa     3960

taaattttat tccaaaataa caaaataaat aatctactgt acacaatctg aaaagaaaaa     4020

aaaaaaaaaa a                                                          4031


<210>  10
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  11
<211>  4050
<212>  DNA
<213>  Homo sapiens

<400>  11
agagctccag ggagggacct gggtagaagg agaagccgga aacagcgggc tggggcagcc       60

actgcttaca ctgaagaggg aggacgggag aggagtgtgt gtgtgtgtgt gtgtgtgtgt      120

gtgtatgtat gtgtgtgctt tatcttattt ttctttttgg tggtggtggt ggaagggggg      180

aggtgctagc agggccagcc ttgaactcgc tggacagagc tacagaccta tggggcctgg      240

aagtgcccgc tgagaaaggg agaagacagc agaggggttg ccgaggtgag gggttgcctc      300

cgaggcaacc tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc      360

agaaaaagtg cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga      420

ctggctggag agccagccct gggagttcct ggtcggctcc gacgccttct gctgcaactt      480

ggctagtgcc ctactttcag acactgtcca gcaccttcag gcctcggtgg gagagcaggg      540

ggaggggagc accatcttgc aacacatcag cacccttgag agcatatatc agagggaccc      600

cctgaagctg gtggccactt tcagacaaat acttcaagga gagaaaaaag ctgttatgga      660

acagttccgc cacttgccaa tgcctttcca ctggaagcag gaagaactca agtttaagac      720

aggcttgcgg aggctgcagc accgagtagg ggagatccac cttctccgag aagccctgca      780

gaagggggct gaggctggcc aagtgtctct gcacagcttg atagaaactc ctgctaatgg      840

gactgggcca agtgaggccc tggccatgct actgcaggag accactggag agctagaggc      900

agccaaagcc ctagtgctga agaggatcca gatttggaaa cggcagcagc agctggcagg      960

gaatggcgca ccgtttgagg agagcctggc cccactccag gagaggtgtg aaagcctggt     1020

ggacatttat tcccagctac agcaggaggt aggggcggct ggtggggagc ttgagcccaa     1080

gacccgggca tcgctgactg gccggctgga tgaagtcctg agaaccctcg tcaccagttg     1140

cttcctggtg gagaagcagc ccccccaggt actgaagact cagaccaagt tccaggctgg     1200

agttcgattc ctgttgggct tgaggttcct gggggcccca gccaagcctc cgctggtcag     1260

ggccgacatg gtgacagaga agcaggcgcg ggagctgagt gtgcctcagg gtcctggggc     1320

tggagcagaa agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc     1380

tgggaactgc tgctctgccc tgttcaagaa cctgcttctc aagaagatca agcggtgtga     1440

gcggaagggc actgagtctg tcacagagga gaagtgcgct gtgctcttct ctgccagctt     1500

cacacttggc cccggcaaac tccccatcca gctccaggcc ctgtctctgc ccctggtggt     1560

catcgtccat ggcaaccaag acaacaatgc caaagccact atcctgtggg acaatgcctt     1620

ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg gtgccctggg agaagatgtg     1680

tgaaactctg aacctgaagt tcatggctga ggtggggacc aaccgggggc tgctcccaga     1740

gcacttcctc ttcctggccc agaagatctt caatgacaac agcctcagta tggaggcctt     1800

ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag atcctgctgg gccgtggctt     1860

caccttttgg cagtggtttg atggtgtcct ggacctcacc aaacgctgtc tccggagcta     1920

ctggtctgac cggctgatca ttggcttcat cagcaaacag tacgttacta gccttcttct     1980

caatgagccc gacggaacct ttctcctccg cttcagcgac tcagagattg ggggcatcac     2040

cattgcccat gtcatccggg gccaggatgg ctctccacag atagagaaca tccagccatt     2100

ctctgccaaa gacctgtcca ttcgctcact gggggaccga atccgggatc ttgctcagct     2160

caaaaatctc tatcccaaga agcccaagga tgaggctttc cggagccact acaagcctga     2220

acagatgggt aaggatggca ggggttatgt cccagctacc atcaagatga ccgtggaaag     2280

ggaccaacca cttcctaccc cagagctcca gatgcctacc atggtgcctt cttatgacct     2340

tggaatggcc cctgattcct ccatgagcat gcagcttggc ccagatatgg tgccccaggt     2400

gtacccacca cactctcact ccatcccccc gtatcaaggc ctctccccag aagaatcagt     2460

caacgtgttg tcagccttcc aggagcctca cctgcagatg ccccccagcc tgggccagat     2520

gagcctgccc tttgaccagc ctcaccccca gggcctgctg ccgtgccagc ctcaggagca     2580

tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg accatggtgg aagacagctg     2640

cctgagccag ccagtgacag cgtttcctca gggcacttgg attggtgaag acatattccc     2700

tcctctgctg cctcccactg aacaggacct cactaagctt ctcctggagg ggcaagggga     2760

gtcgggggga gggtccttgg gggcacagcc cctcctgcag ccctcccact atgggcaatc     2820

tgggatctca atgtcccaca tggacctaag ggccaacccc agttggtgat cccagctgga     2880

gggagaaccc aaagagacag ctcttctact acccccacag acctgctctg gacacttgct     2940

catgccctgc caagcagcag atggggaggg tgccctccta tccccaccta ctcctgggtc     3000

aggaggaaaa gactaacagg agaatgcaca gtgggtggag ccaatccact ccttcctttc     3060

tatcattccc ctgcccacct ccttccagca ctgactggaa gggaagttca ggctctgaga     3120

cacaccccaa catgcctgca cctgcagcgc gcacacgcac gcacacacac atacagagct     3180

ctctgagggt gatggggctg agcaggaggg gggctgggta agagcacagg ttagggcatg     3240

gaaggcttct ccgcccattc tgacccaggg cctaggacgg ataggcagga acatacagac     3300

acatttacac tagaggccag ggatagagga tattgggtct cagccctagg ggaatgggaa     3360

gcagctcaag ggaccctggg tgggagcata ggaggggtct ggacatgtgg ttactagtac     3420

aggttttgcc ctgattaaaa aatctcccaa agccccaaat tcctgttagc caggtggagg     3480

cttctgatac gtgtatgaga ctatgcaaaa gtacaagggc tgagattctt cgtgtatagc     3540

tgtgtgaacg tgtatgtacc taggatatgt taaatgtata gctggcacct tagttgcatg     3600

accacataga acatgtgtct atctgctttt gcctacgtga caacacaaat ttgggagggt     3660

gagacactgc acagaagaca gcagcaagtg tgctggcctc tctgacatat gctaaccccc     3720

aaatactctg aatttggagt ctgactgtgc ccaagtgggt ccaagtggct gtgacatcta     3780

cgtatggctc cacacctcca atgctgcctg ggagccaggg tgagagtctg ggtccaggcc     3840

tggccatgtg gccctccagt gtatgagagg gccctgcctg ctgcatcttt tctgttgccc     3900

catccaccgc cagcttccct tcactcccct atcccattct ccctctcaag gcaggggtca     3960

tagatcctaa gccataaaat aaattttatt ccaaaataac aaaataaata atctactgta     4020

cacaatctga aaagaaaaaa aaaaaaaaaa                                      4050


<210>  12
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  13
<211>  3976
<212>  DNA
<213>  Homo sapiens

<400>  13
cctgtcctgg tcaagccaat cgacccagcc ttgttatggg ttggggtggg gagaaatgtg       60

tcctcctgat ggctggggaa gaagaggggt tggatatttc tagccagggc catgccagga      120

ggctggtcac tctgcaaggg gatgcagagg aaagcggtgc ccactcactc cagaggacct      180

ttctctcttg ggctagagaa aggcctattg gaggaacctg agcaggaggg gcaacctcca      240

agtcccagat catgtctctg tggggtctgg tctccaagat gcccccagaa aaagtgcagc      300

ggctctatgt cgactttccc caacacctgc ggcatcttct gggtgactgg ctggagagcc      360

agccctggga gttcctggtc ggctccgacg ccttctgctg caacttggct agtgccctac      420

tttcagacac tgtccagcac cttcaggcct cggtgggaga gcagggggag gggagcacca      480

tcttgcaaca catcagcacc cttgagagca tatatcagag ggaccccctg aagctggtgg      540

ccactttcag acaaatactt caaggagaga aaaaagctgt tatggaacag ttccgccact      600

tgccaatgcc tttccactgg aagcaggaag aactcaagtt taagacaggc ttgcggaggc      660

tgcagcaccg agtaggggag atccaccttc tccgagaagc cctgcagaag ggggctgagg      720

ctggccaagt gtctctgcac agcttgatag aaactcctgc taatgggact gggccaagtg      780

aggccctggc catgctactg caggagacca ctggagagct agaggcagcc aaagccctag      840

tgctgaagag gatccagatt tggaaacggc agcagcagct ggcagggaat ggcgcaccgt      900

ttgaggagag cctggcccca ctccaggaga ggtgtgaaag cctggtggac atttattccc      960

agctacagca ggaggtaggg gcggctggtg gggagcttga gcccaagacc cgggcatcgc     1020

tgactggccg gctggatgaa gtcctgagaa ccctcgtcac cagttgcttc ctggtggaga     1080

agcagccccc ccaggtactg aagactcaga ccaagttcca ggctggagtt cgattcctgt     1140

tgggcttgag gttcctgggg gccccagcca agcctccgct ggtcagggcc gacatggtga     1200

cagagaagca ggcgcgggag ctgagtgtgc ctcagggtcc tggggctgga gcagaaagca     1260

ctggagaaat catcaacaac actgtgccct tggagaacag cattcctggg aactgctgct     1320

ctgccctgtt caagaacctg cttctcaaga agatcaagcg gtgtgagcgg aagggcactg     1380

agtctgtcac agaggagaag tgcgctgtgc tcttctctgc cagcttcaca cttggccccg     1440

gcaaactccc catccagctc caggccctgt ctctgcccct ggtggtcatc gtccatggca     1500

accaagacaa caatgccaaa gccactatcc tgtgggacaa tgccttctct gagatggacc     1560

gcgtgccctt tgtggtggct gagcgggtgc cctgggagaa gatgtgtgaa actctgaacc     1620

tgaagttcat ggctgaggtg gggaccaacc gggggctgct cccagagcac ttcctcttcc     1680

tggcccagaa gatcttcaat gacaacagcc tcagtatgga ggccttccag caccgttctg     1740

tgtcctggtc gcagttcaac aaggagatcc tgctgggccg tggcttcacc ttttggcagt     1800

ggtttgatgg tgtcctggac ctcaccaaac gctgtctccg gagctactgg tctgaccggc     1860

tgatcattgg cttcatcagc aaacagtacg ttactagcct tcttctcaat gagcccgacg     1920

gaacctttct cctccgcttc agcgactcag agattggggg catcaccatt gcccatgtca     1980

tccggggcca ggatggctct ccacagatag agaacatcca gccattctct gccaaagacc     2040

tgtccattcg ctcactgggg gaccgaatcc gggatcttgc tcagctcaaa aatctctatc     2100

ccaagaagcc caaggatgag gctttccgga gccactacaa gcctgaacag atgggtaagg     2160

atggcagggg ttatgtccca gctaccatca agatgaccgt ggaaagggac caaccacttc     2220

ctaccccaga gctccagatg cctaccatgg tgccttctta tgaccttgga atggcccctg     2280

attcctccat gagcatgcag cttggcccag atatggtgcc ccaggtgtac ccaccacact     2340

ctcactccat ccccccgtat caaggcctct ccccagaaga atcagtcaac gtgttgtcag     2400

ccttccagga gcctcacctg cagatgcccc ccagcctggg ccagatgagc ctgccctttg     2460

accagcctca cccccagggc ctgctgccgt gccagcctca ggagcatgct gtgtccagcc     2520

ctgaccccct gctctgctca gatgtgacca tggtggaaga cagctgcctg agccagccag     2580

tgacagcgtt tcctcagggc acttggattg gtgaagacat attccctcct ctgctgcctc     2640

ccactgaaca ggacctcact aagcttctcc tggaggggca aggggagtcg gggggagggt     2700

ccttgggggc acagcccctc ctgcagccct cccactatgg gcaatctggg atctcaatgt     2760

cccacatgga cctaagggcc aaccccagtt ggtgatccca gctggaggga gaacccaaag     2820

agacagctct tctactaccc ccacagacct gctctggaca cttgctcatg ccctgccaag     2880

cagcagatgg ggagggtgcc ctcctatccc cacctactcc tgggtcagga ggaaaagact     2940

aacaggagaa tgcacagtgg gtggagccaa tccactcctt cctttctatc attcccctgc     3000

ccacctcctt ccagcactga ctggaaggga agttcaggct ctgagacaca ccccaacatg     3060

cctgcacctg cagcgcgcac acgcacgcac acacacatac agagctctct gagggtgatg     3120

gggctgagca ggaggggggc tgggtaagag cacaggttag ggcatggaag gcttctccgc     3180

ccattctgac ccagggccta ggacggatag gcaggaacat acagacacat ttacactaga     3240

ggccagggat agaggatatt gggtctcagc cctaggggaa tgggaagcag ctcaagggac     3300

cctgggtggg agcataggag gggtctggac atgtggttac tagtacaggt tttgccctga     3360

ttaaaaaatc tcccaaagcc ccaaattcct gttagccagg tggaggcttc tgatacgtgt     3420

atgagactat gcaaaagtac aagggctgag attcttcgtg tatagctgtg tgaacgtgta     3480

tgtacctagg atatgttaaa tgtatagctg gcaccttagt tgcatgacca catagaacat     3540

gtgtctatct gcttttgcct acgtgacaac acaaatttgg gagggtgaga cactgcacag     3600

aagacagcag caagtgtgct ggcctctctg acatatgcta acccccaaat actctgaatt     3660

tggagtctga ctgtgcccaa gtgggtccaa gtggctgtga catctacgta tggctccaca     3720

cctccaatgc tgcctgggag ccagggtgag agtctgggtc caggcctggc catgtggccc     3780

tccagtgtat gagagggccc tgcctgctgc atcttttctg ttgccccatc caccgccagc     3840

ttcccttcac tcccctatcc cattctccct ctcaaggcag gggtcataga tcctaagcca     3900

taaaataaat tttattccaa aataacaaaa taaataatct actgtacaca atctgaaaag     3960

aaaaaaaaaa aaaaaa                                                     3976


<210>  14
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  15
<211>  3586
<212>  DNA
<213>  Homo sapiens

<400>  15
ggaaacagcg ggctggggca gccactgctt acactgaaga gggaggacgg gagaggagtg       60

tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tatgtgtgtg ctttatctta tttttctttt      120

tggtggtggt ggtggaaggg gggaggtgct agcagggcca gccttgaact cgctggacag      180

agctacagac ctatggggcc tggaagtgcc cgctgagaaa gggagaagac agcagagggg      240

ttgccgagag aaaggcctat tggaggaacc tgagcaggag gggcaacctc caagtcccag      300

atcatgtctc tgtggggtct ggtctccaag atgcccccag aaaaagtgca gcggctctat      360

gtcgactttc cccaacacct gcggcatctt ctgggtgact ggctggagag ccagccctgg      420

gagttcctgg tcggctccga cgccttctgc tgcaacttgg ctagtgccct actttcagac      480

actgtccagc accttcaggc ctcggtggga gagcaggggg aggggagcac catcttgcaa      540

cacatcagca cccttgagag catatatcag agggaccccc tgaagctggt ggccactttc      600

agacaaatac ttcaaggaga gaaaaaagct gttatggaac agttccgcca cttgccaatg      660

cctttccact ggaagcagga agaactcaag tttaagacag gcttgcggag gctgcagcac      720

cgagtagggg agatccacct tctccgagaa gccctgcaga agggggctga ggctggccaa      780

gtgtctctgc acagcttgat agaaactcct gctaatggga ctgggccaag tgaggccctg      840

gccatgctac tgcaggagac cactggagag ctagaggcag ccaaagccct agtgctgaag      900

aggatccaga tttggaaacg gcagcagcag ctggcaggga atggcgcacc gtttgaggag      960

agcctggccc cactccagga gaggtgtgaa agcctggtgg acatttattc ccagctacag     1020

caggaggtag gggcggctgg tggggagctt gagcccaaga cccgggcatc gctgactggc     1080

cggctggatg aagtcctgag aaccctcgtc accagttgct tcctggtgga gaagcagccc     1140

ccccaggtac tgaagactca gaccaagttc caggctggag ttcgattcct gttgggcttg     1200

aggttcctgg gggccccagc caagcctccg ctggtcaggg ccgacatggt gacagagaag     1260

caggcgcggg agctgagtgt gcctcagggt cctggggctg gagcagaaag cactggagaa     1320

atcatcaaca acactgtgcc cttggagaac agcattcctg ggaactgctg ctctgccctg     1380

ttcaagaacc tgcttctcaa gaagatcaag cggtgtgagc ggaagggcac tgagtctgtc     1440

acagaggaga agtgcgctgt gctcttctct gccagcttca cacttggccc cggcaaactc     1500

cccatccagc tccaggccct gtctctgccc ctggtggtca tcgtccatgg caaccaagac     1560

aacaatgcca aagccactat cctgtgggac aatgccttct ctgagatgga ccgcgtgccc     1620

tttgtggtgg ctgagcgggt gccctgggag aagatgtgtg aaactctgaa cctgaagttc     1680

atggctgagg tggggaccaa ccgggggctg ctcccagagc acttcctctt cctggcccag     1740

aagatcttca atgacaacag cctcagtatg gaggccttcc agcaccgttc tgtgtcctgg     1800

tcgcagttca acaaggagat cctgctgggc cgtggcttca ccttttggca gtggtttgat     1860

ggtgtcctgg acctcaccaa acgctgtctc cggagctact ggtctgaccg gctgatcatt     1920

ggcttcatca gcaaacagta cgttactagc cttcttctca atgagcccga cggaaccttt     1980

ctcctccgct tcagcgactc agagattggg ggcatcacca ttgcccatgt catccggggc     2040

caggatggct ctccacagat agagaacatc cagccattct ctgccaaaga cctgtccatt     2100

cgctcactgg gggaccgaat ccgggatctt gctcagctca aaaatctcta tcccaagaag     2160

cccaaggatg aggctttccg gagccactac aagcctgaac agatgggtaa ggatggcagg     2220

ggttatgtcc cagctaccat caagatgacc gtggaaaggg accaaccact tcctacccca     2280

gagctccaga tgcctaccat ggtgccttct tatgaccttg gaatggcccc tgattcctcc     2340

atgagcatgc agcttggccc agatatggtg ccccaggtgt acccaccaca ctctcactcc     2400

atccccccgt atcaaggcct ctccccagaa gaatcagtca acgtgttgtc agccttccag     2460

gagcctcacc tgcagatgcc ccccagcctg ggccagatga gcctgccctt tgaccagcct     2520

cacccccagg gcctgctgcc gtgccagcct caggagcatg ctgtgtccag ccctgacccc     2580

ctgctctgct cagatgtgac catggtggaa gacagctgcc tgagccagcc agtgacagcg     2640

tttcctcagg gcacttggat tggtgaagac atattccctc ctctgctgcc tcccactgaa     2700

caggacctca ctaagcttct cctggagggg caaggggagt cggggggagg gtccttgggg     2760

gcacagcccc tcctgcagcc ctcccactat gggcaatctg ggatctcaat gtcccacatg     2820

gacctaaggg ccaaccccag ttggtgatcc cagctggagg gagaacccaa agagacagct     2880

cttctactac ccccacagac ctgctctgga cacttgctca tgccctgcca agcagcagat     2940

ggggagggtg ccctcctatc cccacctact cctgggtcag gaggaaaaga ctaacaggag     3000

aatgcacagt gggtggagcc aatccactcc ttcctttcta tcattcccct gcccacctcc     3060

ttccagcact gactggaagg gaagttcagg ctctgagaca caccccaaca tgcctgcacc     3120

tgcagcgcgc acacgcacgc acacacacat acagagctct ctgagggtga tggggctgag     3180

caggaggggg gctgggtaag agcacaggtt agggcatgga aggcttctcc gcccattctg     3240

acccagggcc taggacggat aggcaggaac atacagacac atttacacta gaggccaggg     3300

atagaggata ttgggtctca gccctagggg aatgggaagc agctcaaggg accctgggtg     3360

ggagcatagg aggggtctgg acatgtggtt actagtacag gttttgccct gattaaaaaa     3420

tctcccaaag ccccaaattc ctgttagcca ggtggaggct tctgatacgt gtatgagact     3480

atgcaaaagt acaagggctg agattcttcg tgtatagctg tgtgaacgtg tatgtaccta     3540

ggatatgtta aatgtatagc tggcacctta gttgcatgac cacata                    3586


<210>  16
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  17
<211>  3620
<212>  DNA
<213>  Homo sapiens

<400>  17
ggaaacagcg ggctggggca gccactgctt acactgaaga gggaggacgg gagaggagtg       60

tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tatgtgtgtg ctttatctta tttttctttt      120

tggtggtggt ggtggaaggg gggaggtgct agcagggcca gccttgaact cgctggacag      180

agctacagac ctatggggcc tggaagtgcc cgctgagaaa gggagaagac agcagagggg      240

ttgccgagag aaaggcctat tggaggaacc tgagcaggag gggtaaggat tctgccttga      300

ggagaaaaga gctggggcaa cctccaagtc ccagatcatg tctctgtggg gtctggtctc      360

caagatgccc ccagaaaaag tgcagcggct ctatgtcgac tttccccaac acctgcggca      420

tcttctgggt gactggctgg agagccagcc ctgggagttc ctggtcggct ccgacgcctt      480

ctgctgcaac ttggctagtg ccctactttc agacactgtc cagcaccttc aggcctcggt      540

gggagagcag ggggagggga gcaccatctt gcaacacatc agcacccttg agagcatata      600

tcagagggac cccctgaagc tggtggccac tttcagacaa atacttcaag gagagaaaaa      660

agctgttatg gaacagttcc gccacttgcc aatgcctttc cactggaagc aggaagaact      720

caagtttaag acaggcttgc ggaggctgca gcaccgagta ggggagatcc accttctccg      780

agaagccctg cagaaggggg ctgaggctgg ccaagtgtct ctgcacagct tgatagaaac      840

tcctgctaat gggactgggc caagtgaggc cctggccatg ctactgcagg agaccactgg      900

agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca      960

gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtg     1020

tgaaagcctg gtggacattt attcccagct acagcaggag gtaggggcgg ctggtgggga     1080

gcttgagccc aagacccggg catcgctgac tggccggctg gatgaagtcc tgagaaccct     1140

cgtcaccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa     1200

gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc     1260

tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca     1320

gggtcctggg gctggagcag aaagcactgg agaaatcatc aacaacactg tgcccttgga     1380

gaacagcatt cctgggaact gctgctctgc cctgttcaag aacctgcttc tcaagaagat     1440

caagcggtgt gagcggaagg gcactgagtc tgtcacagag gagaagtgcg ctgtgctctt     1500

ctctgccagc ttcacacttg gccccggcaa actccccatc cagctccagg ccctgtctct     1560

gcccctggtg gtcatcgtcc atggcaacca agacaacaat gccaaagcca ctatcctgtg     1620

ggacaatgcc ttctctgaga tggaccgcgt gccctttgtg gtggctgagc gggtgccctg     1680

ggagaagatg tgtgaaactc tgaacctgaa gttcatggct gaggtgggga ccaaccgggg     1740

gctgctccca gagcacttcc tcttcctggc ccagaagatc ttcaatgaca acagcctcag     1800

tatggaggcc ttccagcacc gttctgtgtc ctggtcgcag ttcaacaagg agatcctgct     1860

gggccgtggc ttcacctttt ggcagtggtt tgatggtgtc ctggacctca ccaaacgctg     1920

tctccggagc tactggtctg accggctgat cattggcttc atcagcaaac agtacgttac     1980

tagccttctt ctcaatgagc ccgacggaac ctttctcctc cgcttcagcg actcagagat     2040

tgggggcatc accattgccc atgtcatccg gggccaggat ggctctccac agatagagaa     2100

catccagcca ttctctgcca aagacctgtc cattcgctca ctgggggacc gaatccggga     2160

tcttgctcag ctcaaaaatc tctatcccaa gaagcccaag gatgaggctt tccggagcca     2220

ctacaagcct gaacagatgg gtaaggatgg caggggttat gtcccagcta ccatcaagat     2280

gaccgtggaa agggaccaac cacttcctac cccagagctc cagatgccta ccatggtgcc     2340

ttcttatgac cttggaatgg cccctgattc ctccatgagc atgcagcttg gcccagatat     2400

ggtgccccag gtgtacccac cacactctca ctccatcccc ccgtatcaag gcctctcccc     2460

agaagaatca gtcaacgtgt tgtcagcctt ccaggagcct cacctgcaga tgccccccag     2520

cctgggccag atgagcctgc cctttgacca gcctcacccc cagggcctgc tgccgtgcca     2580

gcctcaggag catgctgtgt ccagccctga ccccctgctc tgctcagatg tgaccatggt     2640

ggaagacagc tgcctgagcc agccagtgac agcgtttcct cagggcactt ggattggtga     2700

agacatattc cctcctctgc tgcctcccac tgaacaggac ctcactaagc ttctcctgga     2760

ggggcaaggg gagtcggggg gagggtcctt gggggcacag cccctcctgc agccctccca     2820

ctatgggcaa tctgggatct caatgtccca catggaccta agggccaacc ccagttggtg     2880

atcccagctg gagggagaac ccaaagagac agctcttcta ctacccccac agacctgctc     2940

tggacacttg ctcatgccct gccaagcagc agatggggag ggtgccctcc tatccccacc     3000

tactcctggg tcaggaggaa aagactaaca ggagaatgca cagtgggtgg agccaatcca     3060

ctccttcctt tctatcattc ccctgcccac ctccttccag cactgactgg aagggaagtt     3120

caggctctga gacacacccc aacatgcctg cacctgcagc gcgcacacgc acgcacacac     3180

acatacagag ctctctgagg gtgatggggc tgagcaggag gggggctggg taagagcaca     3240

ggttagggca tggaaggctt ctccgcccat tctgacccag ggcctaggac ggataggcag     3300

gaacatacag acacatttac actagaggcc agggatagag gatattgggt ctcagcccta     3360

ggggaatggg aagcagctca agggaccctg ggtgggagca taggaggggt ctggacatgt     3420

ggttactagt acaggttttg ccctgattaa aaaatctccc aaagccccaa attcctgtta     3480

gccaggtgga ggcttctgat acgtgtatga gactatgcaa aagtacaagg gctgagattc     3540

ttcgtgtata gctgtgtgaa cgtgtatgta cctaggatat gttaaatgta tagctggcac     3600

cttagttgca tgaccacata                                                 3620


<210>  18
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  19
<211>  3722
<212>  DNA
<213>  Homo sapiens

<400>  19
ggaaacagcg ggctggggca gccactgctt acactgaaga gggaggacgg gagaggagtg       60

tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tatgtgtgtg ctttatctta tttttctttt      120

tggtggtggt ggtggaaggg gggaggtgct agcagggcca gccttgaact cgctggacag      180

agctacagac ctatggggcc tggaagtgcc cgctgagaaa gggagaagac agcagagggg      240

ttgccgagag aaaggcctat tggaggaacc tgagcaggag gggtaaggat tctgccttga      300

ggagaaaaga gctggggtaa gtgggcactg gaggaaagag gggcatgaag gtcttggagc      360

agaaacgtcc agagaaggga cctctccatt ttccatccct ctgagaggcc tgggagaggc      420

aacctccaag tcccagatca tgtctctgtg gggtctggtc tccaagatgc ccccagaaaa      480

agtgcagcgg ctctatgtcg actttcccca acacctgcgg catcttctgg gtgactggct      540

ggagagccag ccctgggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag      600

tgccctactt tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg      660

gagcaccatc ttgcaacaca tcagcaccct tgagagcata tatcagaggg accccctgaa      720

gctggtggcc actttcagac aaatacttca aggagagaaa aaagctgtta tggaacagtt      780

ccgccacttg ccaatgcctt tccactggaa gcaggaagaa ctcaagttta agacaggctt      840

gcggaggctg cagcaccgag taggggagat ccaccttctc cgagaagccc tgcagaaggg      900

ggctgaggct ggccaagtgt ctctgcacag cttgatagaa actcctgcta atgggactgg      960

gccaagtgag gccctggcca tgctactgca ggagaccact ggagagctag aggcagccaa     1020

agccctagtg ctgaagagga tccagatttg gaaacggcag cagcagctgg cagggaatgg     1080

cgcaccgttt gaggagagcc tggccccact ccaggagagg tgtgaaagcc tggtggacat     1140

ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc ccaagacccg     1200

ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca gttgcttcct     1260

ggtggagaag cagccccccc aggtactgaa gactcagacc aagttccagg ctggagttcg     1320

attcctgttg ggcttgaggt tcctgggggc cccagccaag cctccgctgg tcagggccga     1380

catggtgaca gagaagcagg cgcgggagct gagtgtgcct cagggtcctg gggctggagc     1440

agaaagcact ggagaaatca tcaacaacac tgtgcccttg gagaacagca ttcctgggaa     1500

ctgctgctct gccctgttca agaacctgct tctcaagaag atcaagcggt gtgagcggaa     1560

gggcactgag tctgtcacag aggagaagtg cgctgtgctc ttctctgcca gcttcacact     1620

tggccccggc aaactcccca tccagctcca ggccctgtct ctgcccctgg tggtcatcgt     1680

ccatggcaac caagacaaca atgccaaagc cactatcctg tgggacaatg ccttctctga     1740

gatggaccgc gtgccctttg tggtggctga gcgggtgccc tgggagaaga tgtgtgaaac     1800

tctgaacctg aagttcatgg ctgaggtggg gaccaaccgg gggctgctcc cagagcactt     1860

cctcttcctg gcccagaaga tcttcaatga caacagcctc agtatggagg ccttccagca     1920

ccgttctgtg tcctggtcgc agttcaacaa ggagatcctg ctgggccgtg gcttcacctt     1980

ttggcagtgg tttgatggtg tcctggacct caccaaacgc tgtctccgga gctactggtc     2040

tgaccggctg atcattggct tcatcagcaa acagtacgtt actagccttc ttctcaatga     2100

gcccgacgga acctttctcc tccgcttcag cgactcagag attgggggca tcaccattgc     2160

ccatgtcatc cggggccagg atggctctcc acagatagag aacatccagc cattctctgc     2220

caaagacctg tccattcgct cactggggga ccgaatccgg gatcttgctc agctcaaaaa     2280

tctctatccc aagaagccca aggatgaggc tttccggagc cactacaagc ctgaacagat     2340

gggtaaggat ggcaggggtt atgtcccagc taccatcaag atgaccgtgg aaagggacca     2400

accacttcct accccagagc tccagatgcc taccatggtg ccttcttatg accttggaat     2460

ggcccctgat tcctccatga gcatgcagct tggcccagat atggtgcccc aggtgtaccc     2520

accacactct cactccatcc ccccgtatca aggcctctcc ccagaagaat cagtcaacgt     2580

gttgtcagcc ttccaggagc ctcacctgca gatgcccccc agcctgggcc agatgagcct     2640

gccctttgac cagcctcacc cccagggcct gctgccgtgc cagcctcagg agcatgctgt     2700

gtccagccct gaccccctgc tctgctcaga tgtgaccatg gtggaagaca gctgcctgag     2760

ccagccagtg acagcgtttc ctcagggcac ttggattggt gaagacatat tccctcctct     2820

gctgcctccc actgaacagg acctcactaa gcttctcctg gaggggcaag gggagtcggg     2880

gggagggtcc ttgggggcac agcccctcct gcagccctcc cactatgggc aatctgggat     2940

ctcaatgtcc cacatggacc taagggccaa ccccagttgg tgatcccagc tggagggaga     3000

acccaaagag acagctcttc tactaccccc acagacctgc tctggacact tgctcatgcc     3060

ctgccaagca gcagatgggg agggtgccct cctatcccca cctactcctg ggtcaggagg     3120

aaaagactaa caggagaatg cacagtgggt ggagccaatc cactccttcc tttctatcat     3180

tcccctgccc acctccttcc agcactgact ggaagggaag ttcaggctct gagacacacc     3240

ccaacatgcc tgcacctgca gcgcgcacac gcacgcacac acacatacag agctctctga     3300

gggtgatggg gctgagcagg aggggggctg ggtaagagca caggttaggg catggaaggc     3360

ttctccgccc attctgaccc agggcctagg acggataggc aggaacatac agacacattt     3420

acactagagg ccagggatag aggatattgg gtctcagccc taggggaatg ggaagcagct     3480

caagggaccc tgggtgggag cataggaggg gtctggacat gtggttacta gtacaggttt     3540

tgccctgatt aaaaaatctc ccaaagcccc aaattcctgt tagccaggtg gaggcttctg     3600

atacgtgtat gagactatgc aaaagtacaa gggctgagat tcttcgtgta tagctgtgtg     3660

aacgtgtatg tacctaggat atgttaaatg tatagctggc accttagttg catgaccaca     3720

ta                                                                    3722


<210>  20
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


