                         SEQUENCE LISTING

<110>  Themis Bioscience GmbH
 
<120>  Recombinant Zika vaccines

<130>  TM 5400-02WO

<150>  EP15202480.8
<151>  2015-12-23

<150>  DE102015122740.1
<151>  2015-12-23

<150>  EP16162688.2
<151>  2016-03-29

<160>  192   

<170>  PatentIn version 3.5

<210>  1
<211>  10662
<212>  DNA
<213>  Zika virus strain BeH818995 polyprotein gene

<400>  1
gtgaatcaga ctgcgacagt tcgagtttga agcgaaagct agcaacagta tcaacaggtt       60

ttattttgga tttggaaacg agagtttctg gtcatgaaaa acccaaaaaa gaaatccgga      120

ggattccgga ttgtcaatat gctaaaacgc ggagtagccc gtgtgagccc ctttgggggc      180

ttgaagaggc tgccagccgg acttctgctg ggtcatgggc ccatcaggat ggtcttggcg      240

attctagcct ttttgagatt cacggcaatc aagccatcac tgggtctcat caatagatgg      300

ggttcagtgg ggaaaaaaga ggctatggaa ataataaaga agttcaagaa agatctggct      360

gccatgctga gaataatcaa tgctaggaag gagaagaaga gacgaggcgc agatactagt      420

gtcggaattg ttggcctcct gctgaccaca gctatggcag cggaggtcac tagacgtggg      480

agtgcatact atatgtactt ggacagaaac gatgctgggg aggccatatc ttttccaacc      540

acattgggga tgaataagtg ttatatacag atcatggatc ttggacacat gtgtgatgcc      600

accatgagct atgaatgccc tatgctggat gagggggtgg aaccagatga cgtcgattgt      660

tggtgcaaca cgacgtcaac ttgggttgtg tacggaacct gccatcacaa aaaaggtgaa      720

gcacggagat ctagaagagc tgtgacgctc ccctcccatt ccactaggaa gctgcaaacg      780

cggtcgcaaa cctggttgga atcaagagaa tacacaaagc acttgattag agtcgaaaat      840

tggatattta ggaaccctgg cttcgcgtta gcagcagctg ccatcgcttg gcttttggga      900

agctcaacga gccaaaaagt catatacttg gtcatgatac tgctgattgc cccggcatac      960

agcatcaggt gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggacc     1020

tgggttgatg ttgtcttgga acatggaggt tgtgtcaccg taatggcaca ggacaaaccg     1080

actgtcgaca tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac     1140

tgctatgagg catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa     1200

gcctaccttg acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga     1260

ggctggggaa atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt     1320

gcatgctcca agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata     1380

atgctgtcag ttcatggctc ccagcacagt gggatgattg ttaatgacac aggacatgaa     1440

actgatgaga atagagcgaa agttgagata acgcccaatt caccaagagc cgaagccacc     1500

ctggggggtt ttggaagcct aggacttgat tgtgaaccga ggacaggcct tgacttttca     1560

gatttgtatt acttgactat gaataacaag cactggttgg ttcacaagga gtggttccac     1620

gacattccat taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa     1680

gaagcactgg tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg     1740

agtcaagaag gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt     1800

gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga     1860

ttgaagggcg tgtcatactc cttgtgtact gcagcgttca cattcaccaa gatcccggct     1920

gaaacactgc acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc     1980

aaggttccag ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata     2040

accgctaacc ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat     2100

ccaccatttg gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac     2160

tggcacagga gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag     2220

agaatggcag tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac     2280

tcattgggca agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga     2340

atgtcctggt tctcacaaat tctcattgga acgttgctga tgtggttggg tctgaacaca     2400

aagaatggat ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc     2460

acagccgtct ctgctgatgt ggggtgctcg gtggacttct caaagaagga gacgagatgc     2520

ggtacagggg tgttcgtcta taacgacgtt gaagcctgga gggacaggta caagtaccat     2580

cctgactccc cccgtagatt ggcagcagca gtcaagcaag cctgggaaga tggtatctgc     2640

gggatctcct ctgtttcaag aatggaaaac atcatgtgga gatcagtaga aggggagctc     2700

aacgcaatcc tggaagagaa tggagttcaa ctgacggtcg ttgtgggatc tgtaaaaaac     2760

cccatgtgga gaggtccaca gagattgccc gtgcctgtga acgagctgcc ccacggctgg     2820

aaggcttggg ggaaatcgta cttcgtcaga gcagcaaaga caaataacag ctttgtcgtg     2880

gatggtgaca cactgaagga atgcccactc aaacatagag catggaacag ctttcttgtg     2940

gaggatcatg ggttcggggt atttcacact agtgtctggc tcaaggttag agaagattat     3000

tcattagagt gtgatccagc cgttattgga acagctgtta agggaaagga ggctgtacac     3060

agtgatctag gctactggat tgagagtgag aagaatgaca catggaggct gaagagggcc     3120

catctgatcg agatgaaaac atgtgaatgg ccaaagtccc acacattgtg gacagatgga     3180

atagaagaga gtgatctgat catacccaag tctttagctg ggccactcag ccatcacaat     3240

accagagagg gctacaggac ccaaatgaaa gggccatggc acagtgaaga gcttgaaatt     3300

cggtttgagg aatgcccagg cactaaggtc cacgtggagg aaacatgtgg aacaagagga     3360

ccatctctga gatcaaccac tgcaagcgga agggtgatcg aggaatggtg ctgcagggag     3420

tgcacaatgc ccccactgtc gttccgggct aaagatggct gttggtatgg aatggagata     3480

aggcccagga aagaaccaga aagcaactta gtaaggtcaa tggtgactgc aggatcaact     3540

gatcacatgg accacttctc ccttggagtg cttgtgattc tgctcatggt gcaggaaggg     3600

ctgaagaaga gaatgaccac aaagatcatc ataagcacat caatggcagt gctggtagct     3660

atgatcctgg gaggattttc aatgagtgac ctggctaagc ttgcaatttt gatgggtgcc     3720

accttcgcgg aaatgaacac tggaggagat gtagctcatc tggcgctgat agcggcattc     3780

aaagtcagac cagcgttgct ggtatctttc atcttcagag ctaattggac accccgtgaa     3840

agcatgctgc tggccttggc ctcgtgtctt ttgcaaactg cgatctccgc cttggaaggc     3900

gacctgatgg ttctcatcaa tggttttgct ttggcctggt tggcaatacg agcgatggtt     3960

gttccacgca ctgataacat caccttggca atcctggctg ctctgacacc actggcccgg     4020

ggcacactgc ttgtggcgtg gagagcaggc cttgctactt gcggggggtt tatgctcctc     4080

tctctgaagg gaaaaggcag tgtgaagaag aacttaccat ttgtcatggc cctgggacta     4140

accgctgtga ggctggtcga ccccatcaac gtggtgggac tgctgttgct cacaaggagt     4200

gggaagcgga gctggccccc tagcgaagta ctcacagctg ttggcctgat atgcgcattg     4260

gctggagggt tcgccaaggc agatatagag atggctgggc ccatggccgc ggtcggtctg     4320

ctaattgtca gttacgtggt ctcaggaaag agtgtggaca tgtacattga aagagcaggt     4380

gacatcacat gggaaaaaga tgcggaagtc actggaaaca gtccccggct cgatgtggcg     4440

ctagatgaga gtggtgattt ctccctggtg gaggatgacg gtccccccat gagagagatc     4500

atactcaagg tggtcctgat gaccatctgt ggcatgaacc caatagccat accctttgca     4560

gctggagcgt ggtacgtata cgtgaagact ggaaaaagga gtggtgctct atgggatgtg     4620

cctgctccca aggaagtaaa aaagggggag accacagatg gagtgtacag agtaatgact     4680

cgtagactgc taggttcaac acaagttgga gtgggagtta tgcaagaggg ggtctttcac     4740

actatgtggc acgtcacaaa aggatccgcg ctgagaagcg gtgaagggag acttgatcca     4800

tactggggag atgtcaagca ggatctggtg tcatactgtg gtccatggaa gctagatgcc     4860

gcctgggacg ggcacagcga ggtgcagctc ttggccgtgc cccccggaga gagagcgagg     4920

aacatccaga ctctgcccgg aatatttaag acaaaggatg gggacattgg agcggttgcg     4980

ctggattacc cagcaggaac ttcaggatct ccaatcctag acaagtgtgg gagagtgata     5040

ggactttatg gcaatggggt cgtgatcaaa aatgggagtt atgttagtgc catcacccaa     5100

gggaggaggg aggaagagac tcctgttgag tgcttcgagc cttcgatgct gaagaagaag     5160

cagctaactg tcttagactt gcatcctgga gctgggaaaa ccaggagagt tcttcctgaa     5220

atagtccgtg aagccataaa aacaagactc cgcaccgtga tcttagctcc aaccagggtt     5280

gtcgctgctg aaatggagga ggcccttaga gggcttccag tgcgttatat gacaacagca     5340

gtcaatgtca cccactctgg aacagaaatc gtcgacttaa tgtgccatgc caccttcact     5400

tcacgtctac tacagccaat cagagtcccc aactataatc tgtatattat ggatgaggcc     5460

cacttcacag atccctcaag tatagcagca agaggataca tttcaacaag ggttgagatg     5520

ggcgaggcgg ctgccatctt catgaccgcc acgccaccag gaacccgtga cgcatttccg     5580

gactccaact caccaattat ggacaccgaa gtggaagtcc cagagagagc ctggagctca     5640

ggctttgatt gggtgacgga tcattctgga aaaacagttt ggtttgttcc aagcgtgagg     5700

aacggcaatg agatcgcagc ttgtctgaca aaggctggaa aacgggtcat acagctcagc     5760

agaaagactt ttgagacaga gttccagaaa acaaaacatc aagagtggga ctttgtcgtg     5820

acaactgaca tttcagagat gggcgccaac tttaaagctg accgtgtcat agattccagg     5880

agatgcctaa agccggtcat acttgatggc gagagagtca ttctggctgg acccatgcct     5940

gtcacacatg ccagcgctgc ccagaggagg gggcgcatag gcaggaatcc caacaaacct     6000

ggagatgagt atctgtatgg aggtgggtgc gcagagactg acgaagacca tgcacactgg     6060

cttgaagcaa gaatgctcct tgacaatatt tacctccaag atggcctcat agcctcgctc     6120

tatcgacctg aggccgacaa agtagcagcc attgagggag agttcaagct taggacggag     6180

caaaggaaga cctttgtgga actcatgaaa agaggagatc ttcctgtttg gctggcctat     6240

caggttgcat ctgccggaat aacctacaca gatagaagat ggtgctttga tggcacgacc     6300

aacaacacca taatggaaga cagtgtgccg gcagaggtgt ggaccagaca cggagagaaa     6360

agagtgctca aaccgaggtg gatggacgcc agagtttgtt cagatcatgc ggccctgaag     6420

tcattcaagg agtttgccgc tgggaaaaga ggagcggctt ttggagtgat ggaagccctg     6480

ggaacactgc caggacacat gacagagaga ttccaggaag ccattgacaa cctcgctgtg     6540

ctcatgcggg cagagactgg aagcaggcct tacaaagccg cggcggccca attgccggag     6600

accctagaga ccattatgct tttggggttg ctgggaacag tctcgctggg aatcttcttc     6660

gtcttgatga ggaacaaggg catagggaag atgggctttg gaatggtgac tcttggggcc     6720

agcgcatggc tcatgtggct ctcggaaatt gagccagcca gaattgcatg tgtcctcatt     6780

gttgtgtttc tattgctggt ggtgctcata cctgagccag aaaagcaaag atctccccag     6840

gacaaccaaa tggcaatcat catcatggta gcagtaggtc ttctgggctt gattaccgcc     6900

aatgaactcg gatggttgga gagaacaaag agtgacctaa gccatctaat gggaaggaga     6960

gaggaggggg caaccatagg attctcaatg gacattgacc tgcggccagc ctcagcttgg     7020

gccatctatg ctgccttgac aactttcatt accccagccg tccaacatgc agtgaccact     7080

tcatacaaca actactcctt aatggcgatg gccacgcaag ctggagtgtt gtttggtatg     7140

ggcaaaggga tgccattcta cgcatgggac tttggagtcc cgctgctaat gataggttgc     7200

tactcacaat taacacccct gaccctaata gtggccatca ttttgctcgt ggcgcactac     7260

atgtacttga tcccagggct gcaggcagca gctgcgcgtg ctgcccagaa gagaacggca     7320

gctggcatca tgaagaaccc tgttgtggat ggaatagtgg tgactgacat tgacacaatg     7380

acaattgacc cccaagtgga gaaaaagatg ggacaggtgc tactcatagc agtagccgtc     7440

tccagcgcca tactgtcgcg gaccgcctgg gggtgggggg aggctggggc cctgatcaca     7500

gccgcaactt ccactttgtg ggaaggctct ccgaacaagt actggaactc ctctacagcc     7560

acttcactgt gtaacatttt taggggaagt tacttggctg gagcttctct aatctacaca     7620

gtaacaagaa acgctggctt ggtcaagaga cgtgggggtg gaacaggaga gaccctggga     7680

gagaaatgga aggcccgctt gaaccagatg tcggccctgg agttctactc ctacaaaaag     7740

tcaggcatca ccgaggtgtg cagagaagag gcccgccgcg ccctcaagga cggtgtggca     7800

acgggaggcc atgctgtgtc ccgaggaagt gcaaagctga gatggttggt ggagcgggga     7860

tacctgcagc cctatggaaa ggtcattgat cttggatgtg gcagaggggg ctggagttac     7920

tacgccgcca ccatccgcaa agttcaagaa gtgaaaggat acacaaaagg aggccctggt     7980

catgaagaac ccgtgttggt gcaaagctat gggtggaaca tagtccgtct taagagtggg     8040

gtggacgtct ttcatatggc ggctgagccg tgtgacacgt tgctgtgtga cataggtgag     8100

tcatcatcta gtcctgaagt ggaagaagca cggacgctca gagtcctctc catggtgggg     8160

gattggcttg aaaaaagacc aggagccttt tgtataaagg tgttgtgccc atacaccagc     8220

actatgatgg aaaccctgga gcgactgcag cgtaggtatg ggggaggact ggtcagagtg     8280

ccactctccc gcaactctac acatgagatg tattgggtct ctggagcgaa aagcaacacc     8340

ataaaaagtg tgtccaccac gagccagctc ctcttggggc gcatggacgg gcctaggagg     8400

ccagtgaaat atgaggagga tgtggatctc ggctctggca cgcgggctgt ggtaagctgc     8460

gctgaagctc ccaacatgaa gatcattggt aaccgcattg aaaggatccg cagtgagcac     8520

gcggaaacgt ggttctttga cgagaaccac ccatatagga catgggctta ccatggaagc     8580

tatgaggccc ccacacaagg gtcagcgtcc tctctaataa acggggttgt caggctcctg     8640

tcaaaaccct gggatgtggt gactggagtc acaggaatag ccatgaccga caccacaccg     8700

tatggtcagc aaagagtttt caaggaaaaa gtggacacta gggtgccaga cccccaagaa     8760

ggcactcgtc aggttatgag catggtctct tcctggttgt ggaaagagct aggcaaacac     8820

aaacggccac gagtctgtac caaagaagag ttcatcaaca aggttcgtag caatgcagca     8880

ttaggggcaa tatttgaaga ggaaaaagag tggaagactg cagtggaagc tgtgaacgat     8940

ccaaggttct gggctctagt ggataaggaa agagagcacc acctgagagg agagtgccag     9000

agttgtgtgt acaacatgat gggaaaaaga gaaaagaaac aaggggaatt tggaaaggcc     9060

aagggcagcc gcgccatctg gtatatgtgg ctaggggcta gatttctaga gttcgaagcc     9120

cttggattct tgaacgagga tcactggatg gggagagaga actcaggagg tggtgttgaa     9180

gggctgggat tacaaagact cggatatgtc ctagaagaga tgagtcgtat accaggagga     9240

aggatgtatg cagatgacac tgctggctgg gacacccgca tcagcaggtt tgatctggag     9300

aatgaagctc taatcaccaa ccaaatggaa aaagggcaca gggccttggc attggccata     9360

atcaagtaca cataccaaaa caaagtggta aaggtcctta gaccagctga aaaagggaaa     9420

acagttatgg acattatttc gagacaagac caaaggggga gcggacaagt tgtcacttac     9480

gctcttaaca catttaccaa cctagtggtg caactcattc ggaatatgga ggctgaggaa     9540

gttctagaga tgcaagactt gtggctgctg cggaggtcag agaaagtgac caactggttg     9600

cagagcaacg gatgggatag gctcaaacga atggcagtca gtggagatga ttgcgttgtg     9660

aagccaattg atgataggtt tgcacatgcc ctcaggttct tgaatgatat gggaaaagtt     9720

aggaaggaca cacaagagtg gaaaccctca actggatggg acaactggga agaagttccg     9780

ttttgctccc accacttcaa caagctccat ctcaaggacg ggaggtccat tgtggttccc     9840

tgccgccacc aagatgaact gattggccgg gcccgcgtct ctccaggggc gggatggagc     9900

atccgggaga ctgcttgcct agcaaaatca tatgcgcaaa tgtggcagct cctttatttc     9960

cacagaaggg acctccgact gatggccaat gccatttgtt catctgtgcc agttgactgg    10020

gttccaactg ggagaactac ctggtcaatc catggaaagg gagaatggat gaccactgaa    10080

gacatgcttg tggtgtggaa cagagtgtgg attgaggaga acgaccacat ggaagacaag    10140

accccagtta cgaaatggac agacatcccc tatttgggaa aaagggaaga cttgtggtgt    10200

ggatctctca tagggcacag accgcgcacc acctgggctg agaacattaa aaacacagtc    10260

aacatggtgc gcaggatcat aggtgatgaa gaaaagtaca tggactacct atccacccaa    10320

gttcgctact tgggtgaaga agggtctaca cctggagtgc tgtaagcacc agtcttaatg    10380

ttgtcaggcc tgctagtcag ccacagcttg gggaaagctg tgcagcctgt gaccccccag    10440

gagaagctgg gaaaccaagc ctatagtcag gccgagaacg ccatggcacg gaagaagcca    10500

tgctgcctgt gagcccctca gaggacactg agtcaaaaaa ccccacgcgc ttggaggcgc    10560

aggatgggaa aagaaggtgg cgaccttccc cacccttcaa tctggggcct gaactggaga    10620

tcagctgtgg atctccagaa gagggactag tggttagagg ag                       10662


<210>  2
<211>  10648
<212>  DNA
<213>  Zika virus isolate SSABR1, complete genome

<400>  2
gacagttcga gtttgaagcg aaagctagca acagtatcaa caggttttat ttggatttgg       60

aaacgagagt ttctggtcat gaaaaaccca aaaaagaaat ccggaggatt ccggattgtc      120

aatatgctaa aacgcggagt agcccgtgtg agcccctttg ggggcttgaa gaggctgcca      180

gccggacttc tgctgggtca tgggcccatc aggatggtct tggcgattct agcctttttg      240

agattcacgg caatcaagcc atcactgggt ctcatcaata gatggggttc agtggggaaa      300

aaagaggcta tggaaataat aaagaagttc aagaaagatc tggctgccat gctgagaata      360

atcaatgcta ggaaggagaa gaagagacga ggcgcagata ctagtgtcgg aattgttggc      420

ctcctgctga ccacagctat ggcagcggag gtcactagac gtgggagtgc atactatatg      480

tacttggaca gaaacgatgc tggggaggcc atatcttttc caaccacatt ggggatgaat      540

aagtgttata tacagatcat ggatcttgga cacatgtgtg atgccaccat gagctatgaa      600

tgccctatgc tggatgaggg ggtggaacca gatgacgtcg attgttggtg caacacgacg      660

tcaacttggg ttgtgtacgg aacctgccat cacaaaaaag gtgaagcacg gagatctaga      720

agagctgtga cgctcccctc ccattccact aggaagctgc aaacgcggtc gcaaacctgg      780

ttggaatcaa gagaatacac aaagcacttg attagagtcg aaaattggat attcaggaac      840

cctggcttcg cgttagcagc agctgccatc gcttggcttt tgggaagctc aacgagccaa      900

aaagtcatat acttggtcat gatactgctg attgccccgg catacagcat caggtgcata      960

ggagtcagca atagggactt tgtggaaggt atgtcaggtg ggacctgggt tgatgttgtc     1020

ttggaacatg gaggttgtgt caccgtaatg gcacaggaca aaccgactgt cgacatagag     1080

ctggttacaa caacagtcag caacatggcg gaggtaagat cctactgcta tgaggcatca     1140

atatcagaca tggcttcgga cagccgctgc ccaacacaag gtgaagccta ccttgacaag     1200

caatcagaca ctcaatatgt ctgcaaaaga acgttagtgg acagaggctg gggaaatgga     1260

tgtggacttt ttggcaaagg gagcctggtg acatgcgcta agtttgcatg ctccaagaaa     1320

atgaccggga agagcatcca gccagagaat ctggagtacc ggataatgct gtcagttcat     1380

ggctcccagc acagtgggat gattgttaat gacacaggac atgaaactga tgagaataga     1440

gcgaaagttg agataacgcc caattcacca agagccgaag ccaccctggg gggttttgga     1500

agcctaggac ttgattgtga accgaggaca ggccttgact tttcagattt gtattacttg     1560

actatgaata acaagcactg gttggttcac aaggagtggt tccacgacat tccattacct     1620

tggcacgctg gggcagacac cggaactcca cactggaaca acaaagaagc actggtagag     1680

ttcaaggacg cacatgccaa aaggcaaact gtcgtggttc tagggagtca agaaggagca     1740

gttcacacgg cccttgctgg agctctggag gctgagatgg atggtgcaaa gggaaggctg     1800

tcctctggcc acttgaaatg tcgcctgaaa atggataaac ttagattgaa gggcgtgtca     1860

tactccttgt gtactgcagc gttcacattc accaagatcc cggctgaaac actgcacggg     1920

acagtcacag tggaggtaca gtacgcaggg acagatggac cttgcaaggt tccagctcag     1980

atggcggtgg acatgcaaac tctgacccca gttgggaggt tgataaccgc taaccccgta     2040

atcactgaaa gcactgagaa ctctaagatg atgctggaac ttgatccacc atttggggac     2100

tcttacattg tcataggagt cggggagaag aagatcaccc accactggca caggagtggc     2160

agcaccattg gaaaagcatt tgaagccact gtgagaggtg ccaagagaat ggcagtcttg     2220

ggagacacag cctgggactt tggatcagtt ggaggcgctc tcaactcatt gggcaagggc     2280

atccatcaaa tttttggagc agctttcaaa tcattgtttg gaggaatgtc ctggttctca     2340

caaattctca ttggaacgtt gctgatgtgg ttgggtctga acacaaagaa tggatctatt     2400

tcccttatgt gcttggcctt agggggagtg ttgatcttct tatccacagc cgtctctgct     2460

gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc     2520

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt     2580

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt     2640

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa     2700

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat gtggagaggt     2760

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa     2820

tcgtacttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg     2880

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc     2940

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat     3000

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac     3060

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg     3120

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat     3180

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac     3240

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc     3300

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca     3360

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca     3420

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     3480

ccagaaagca acttagtaag gtcaatggtg actgcaggat caactgatca catggaccac     3540

ttctcccttg gagtgcttgt gattctgctc atggtgcagg aagggctgaa gaagagaatg     3600

accacaaaga tcatcataag cacatcaatg gcagtgctgg tagctatgat cctgggagga     3660

ttttcaatga gtgacctggc taagcttgca attttgatgg gtgccacctt cgcggaaatg     3720

aacactggag gagatgtagc tcatctggcg ctgatagcgg cattcaaagt cagaccagcg     3780

ttgctggtat ctttcatctt cagagctaat tggacacccc gtgaaagcat gctgctggcc     3840

ttggcctcgt gtcttttgca aactgcgatc tccgccttgg aaggcgacct gatggttctc     3900

atcaatggtt ttgctttggc ctggttggca atacgagcga tggttgttcc acgcactgat     3960

aacatcacct tggcaatcct ggctgctctg acaccactgg cccggggcac actgcttgtg     4020

gcgtggagag caggccttgc tacttgcggg gggtttatgc tcctctctct gaagggaaaa     4080

ggcagtgtga agaagaactt accatttgtc atggccctgg gactaaccgc tgtgaggctg     4140

gtcgacccca tcaacgtggt gggactgctg ttgctcacaa ggagtgggaa gcggagctgg     4200

ccccctagcg aagtactcac agctgttggc ctgatatgcg cattggctgg agggttcgcc     4260

aaggcagata tagagatggc tgggcccatg gccgcggtcg gtctgctaat tgtcagttac     4320

gtggtctcag gaaagagtgt ggacatgtac attgaaagag caggtgacat cacatgggaa     4380

aaagatgcgg aagtcactgg aaacagtccc cggctcgatg tggcgctaga tgagagtggt     4440

gatttctccc tggtggagga tgacggtccc cccatgagag agatcatact caaggtggtc     4500

ctgatgacca tctgtggcat gaacccaata gccataccct ttgcagctgg agcgtggtac     4560

gtatacgtga agactggaaa aaggagtggt gctctatggg atgtgcctgc tcccaaggaa     4620

gtaaaaaagg gggagaccac agatggagtg tacagagtaa tgactcgtag actgctaggt     4680

tcaacacaag ttggagtggg agttatgcaa gagggggtct ttcacactat gtggcacgtc     4740

acaaaaggat ccgcgctgag aagcggtgaa gggagacttg atccatactg gggagatgtc     4800

aagcaggatc tggtgtcata ctgtggtcca tggaagctag atgccgcctg ggacgggcac     4860

agcgaggtgc agctcttggc cgtgcccccc ggagagagag cgaggaacat ccagactctg     4920

cccggaatat ttaagacaaa ggatggggac attggagcgg ttgcgctgga ttacccagca     4980

ggaacttcag gatctccaat cctagacaag tgtgggagag tgataggact ttatggcaat     5040

ggggtcgtga tcaaaaatgg gagttatgtt agtgccatca cccaagggag gagggaggaa     5100

gagactcctg ttgagtgctt cgagccttcg atgctgaaga agaagcagct aactgtctta     5160

gacttgcatc ctggagctgg gaaaaccagg agagttcttc ctgaaatagt ccgtgaagcc     5220

ataaaaacaa gactccgtac tgtgatctta gctccaacca gggttgtcgc tgctgaaatg     5280

gaggaggccc ttagagggct tccagtgcgt tatatgacaa cagcagtcaa tgtcacccac     5340

tctggaacag aaatcgtcga cttaatgtgc catgccacct tcacttcacg tctactacag     5400

ccaatcagag tccccaacta taatctgtat attatggatg aggcccactt cacagatccc     5460

tcaagtatag cagcaagagg atacatttca acaagggttg agatgggcga ggcggctgcc     5520

atcttcatga ccgccacgcc accaggaacc cgtgacgcat ttccggactc caactcacca     5580

attatggaca ccgaagtgga agtcccagag agagcctgga gctcaggctt tgattgggtg     5640

acggatcatt ctggaaaaac agtttggttt gttccaagcg tgaggaacgg caatgagatc     5700

gcagcttgtc tgacaaaggc tggaaaacgg gtcatacagc tcagcagaaa gacttttgag     5760

acagagttcc agaaaacaaa acatcaagag tgggactttg tcgtgacaac tgacatttca     5820

gagatgggcg ccaactttaa agctgaccgt gtcatagatt ccaggagatg cctaaagccg     5880

gtcatacttg atggcgagag agtcattctg gctggaccca tgcctgtcac acatgccagc     5940

gctgcccaga ggagggggcg cataggcagg aatcccaaca aacctggaga tgagtatctg     6000

tatggaggtg ggtgcgcaga gactgacgaa gaccatgcac actggcttga agcaagaatg     6060

ctccttgaca atatttacct ccaagatggc ctcatagcct cgctctatcg acctgaggcc     6120

gacaaagtag cagccattga gggagagttc aagcttagga cggagcaaag gaagaccttt     6180

gtggaactca tgaaaagagg agatcttcct gtttggctgg cctatcaggt tgcatctgcc     6240

ggaataacct acacagatag aagatggtgc tttgatggca cgaccaacaa caccataatg     6300

gaagacagtg tgccggcaga ggtgtggacc agacacggag agaaaagagt gctcaaaccg     6360

aggtggatgg acgccagagt ttgttcagat catgcggccc tgaagtcatt caaggagttt     6420

gccgctggga aaagaggagc ggcttttgga gtgatggaag ccctgggaac actgccagga     6480

cacatgacag agagattcca ggaagccatt gacaacctcg ctgtgctcat gcgggcagag     6540

actggaagca ggccttacaa agccgcggcg gcccaattgc cggagaccct agagaccatt     6600

atgcttttgg ggttgctggg aacagtctcg ctgggaatct tcttcgtctt gatgaggaac     6660

aagggcatag ggaagatggg ctttggaatg gtgactcttg gggccagcgc atggctcatg     6720

tggctctcgg aaattgagcc agccagaatt gcatgtgtcc tcattgttgt gtttctattg     6780

ctggtggtgc tcatacctga gccagaaaag caaagatctc cccaggacaa ccaaatggca     6840

atcatcatca tggtagcagt aggtcttctg ggcttgatta ccgccaatga actcggatgg     6900

ttggagagaa caaagagtga cctaagccat ctaatgggaa ggagagagga gggggcaacc     6960

ataggattct caatggacat tgacctgcgg ccagcctcag cttgggccat ctatgctgcc     7020

ttgacaactt tcattacccc agccgtccaa catgcagtga ccacttcata caacaactac     7080

tccttaatgg cgatggccac gcaagctgga gtgttgtttg gtatgggcaa agggatgcca     7140

ttctacgcat gggactttgg agtcccgctg ctaatgatag gttgctactc acaattaaca     7200

cccctgaccc taatagtggc catcattttg ctcgtggcgc actacatgta cttgatccca     7260

gggctgcagg cagcagctgc gcgtgctgcc cagaagagaa cggcagctgg catcatgaag     7320

aaccctgttg tggatggaat agtggtgact gacattgaca caatgacaat tgacccccaa     7380

gtggagaaaa agatgggaca ggtgctactc atagcagtag ccgtctccag cgccatactg     7440

tcgcggaccg cctgggggtg gggggaggct ggggccctga tcacagccgc aacttccact     7500

ttgtgggaag gctctccgaa caagtactgg aactcctcta cagccacttc actgtgtaac     7560

atttttaggg gaagttactt ggctggagct tctctaatct acacagtaac aagaaacgct     7620

ggcttggtca agagacgtgg gggtggaaca ggagagaccc tgggagagaa atggaaggcc     7680

cgcttgaacc agatgtcggc cctggagttc tactcctaca aaaagtcagg catcaccgag     7740

gtgtgcagag aagaggcccg ccgcgccctc aaggacggtg tggcaacggg aggccatgct     7800

gtgtcccgag gaagtgcaaa gctgagatgg ttggtggagc ggggatacct gcagccctat     7860

ggaaaggtca ttgatcttgg atgtggcaga gggggctgga gttactacgc cgccaccatc     7920

cgcaaagttc aagaagtgaa aggatacaca aaaggaggcc ctggtcatga agaacccgtg     7980

ttggtgcaaa gctatgggtg gaacatagtc cgtcttaaga gtggggtgga cgtctttcat     8040

atggcggctg agccgtgtga cacgttgctg tgtgacatag gtgagtcatc atctagtcct     8100

gaagtggaag aagcacggac gctcagagtc ctctccatgg tgggggattg gcttgaaaaa     8160

agaccaggag ccttttgtat aaaggtgttg tgcccataca ccagcactat gatggaaacc     8220

ctggagcgac tgcagcgtag gtatggggga ggactggtca gagtgccact ctcccgcaac     8280

tctacacatg agatgtattg ggtctctgga gcgaaaagca acaccataaa aagtgtgtcc     8340

accacgagcc agctcctctt ggggcgcatg gacgggccta ggaggccagt gaaatatgag     8400

gaggatgtga atctcggctc tggcacgcgg gctgtggtaa gctgcgctga agctcccaac     8460

atgaagatca ttggtaaccg cattgaaagg atccgcagtg agcacgcgga aacgtggttc     8520

tttgacgaga accacccata taggacatgg gcttaccatg gaagctatga ggcccccaca     8580

caagggtcag cgtcctctct aataaacggg gttgtcaggc tcctgtcaaa accctgggat     8640

gtggtgactg gagtcacagg aatagccatg accgacacca caccgtatgg tcagcaaaga     8700

gttttcaagg aaaaagtgga cactagggtg ccagaccccc aagaaggcac tcgtcaggtt     8760

atgagcatgg tctcttcctg gttgtggaaa gagctaggca aacacaaacg gccacgagtc     8820

tgtaccaaag aagagttcat caacaaggtt cgtagcaatg cagcattagg ggcaatattt     8880

gaagaggaaa aagagtggaa gactgcagtg gaagctgtga acgatccaag gttctgggct     8940

ctagtggata aggaaagaga gcaccacctg agaggagagt gccagagttg tgtgtacaac     9000

atgatgggaa aaagagaaaa gaaacaaggg gaatttggaa aggccaaggg cagccgcgcc     9060

atctggtata tgtggctagg ggctagattt ctagagttcg aagcccttgg attcttgaac     9120

gaggatcact ggatggggag agagaactca ggaggtggtg ttgaagggct gggattacaa     9180

agactcggat atgtcctaga agagatgagt cgtataccag gaggaaggat gtatgcagat     9240

gacactgctg gctgggacac ccgcatcagc aggtttgatc tggagaatga agctctaatc     9300

accaaccaaa tggaaaaagg gcacagggcc ttggcattgg ccataatcaa gtacacatac     9360

caaaacaaag tggtaaaggt ccttagacca gctgaaaaag ggaaaacagt tatggacatt     9420

atttcgagac aagaccaaag ggggagcgga caagttgtca cttacgctct taacacattt     9480

accaacctag tggtgcaact cattcggaat atggaggctg aggaagttct agagatgcaa     9540

gacttgtggc tgctgcggag gtcagagaaa gtgaccaact ggttgcagag caacggatgg     9600

gataggctca aacgaatggc agtcagtgga gatgattgcg ttgtgaagcc aattgatgat     9660

aggtttgcac atgccctcag gttcttgaat gatatgggaa aagttaggaa ggacacacaa     9720

gagtggaaac cctcaactgg atgggacaac tgggaagaag ttccgttttg ctcccaccac     9780

ttcaacaagc tccatctcaa ggacgggagg tccattgtgg ttccctgccg ccaccaagat     9840

gaactgattg gccgggcccg cgtctctcca ggggcgggat ggagcatccg ggagactgct     9900

tgcctagcaa aatcatatgc gcaaatgtgg cagctccttt atttccacag aagggacctc     9960

cgactgatgg ccaatgccat ttgttcatct gtgccagttg actgggttcc aactgggaga    10020

actacctggt caatccatgg aaagggagaa tggatgacca ctgaagacat gcttgtggtg    10080

tggaacagag tgtggattga ggagaacgac cacatggaag acaagacccc agttacgaaa    10140

tggacagaca tcccctattt gggaaaaagg gaagacttgt ggtgtggatc tctcataggg    10200

cacagaccgc gcaccacctg ggctgagaac attaaaaaca cagtcaacat ggtgcgcagg    10260

atcataggtg atgaagaaaa gtacatggac tacctatcca cccaagttcg ctacttgggt    10320

gaagaagggt ctacacctgg agtgctgtaa gcaccagtct taatgttgtc aggcctgcta    10380

gtcagccaca gcttggggaa agctgtgcag cctgtgaccc ccccaggaga agctgggaaa    10440

ccaagcctat agtcaggccg agaacgccat ggcacggaag aagccatgct gcctgtgagc    10500

ccctcagagg acactgagtc aaaaaacccc acgcgcttgg aggcgcagga tgggaaaaga    10560

aggtggcgac cttccccacc cttcaatctg gggcctgaac tggagatcag ctgtggatct    10620

ccagaagagg gactagtggt tagaggag                                       10648


<210>  3
<211>  10808
<212>  DNA
<213>  Zika virus strain Natal RGN, complete genome

<400>  3
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcaattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggtccaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg taccgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaatcctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga gaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcttggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcgaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggga     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatcta atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtgggcaga tggaatagaa gagagtgatc tgatcattcc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc cgggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcagtggtga     3540

ctgcaggatc aactgatcac atggatcact tctcccttgg agtgcttgtg attctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg cgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaatggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5160

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaagccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattttgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt tttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggagcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc agtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggccctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta catagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggatggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagttgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gcataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcatcagca     9300

ggttcgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg catagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

tgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtctt                                                             10808


<210>  4
<211>  10676
<212>  DNA
<213>  Zika virus strain Haiti/1225/2014, complete genome

<400>  4
gttgttactg ttgctgactc agactgcgac agttcgagtt tgaagcgaaa gctagcaaca       60

gtatcaacag gttttatttg gatttggaaa cgagagtttc tggtcatgaa aaacccaaaa      120

aagaaatccg gaggattccg gattgtcaat atgctaaaac gcggagtagc ccgtgtgagc      180

ccctttgggg gcttgaagag gctgccagcc ggacttctgc tgggtcatgg gcccatcagg      240

atggtcttgg caattctagc ctttttgaga ttcacggcaa tcaagccatc actgggtctc      300

atcaatagat ggggttcagt ggggaaaaaa gaggctatgg aaataataaa gaagttcaag      360

aaagatctgg ctgccatgct gagaataatc aatgctagga aggagaagaa gagacgaggc      420

gcagatacta gtgtcggaat tgttggcctc ctgctgacca cagctatggc agcggaggtc      480

actagacgtg ggagtgcata ctatatgtac ttggacagaa acgatgctgg ggaggccata      540

tcttttccaa ccacattggg gatgaataag tgttatatac agatcatgga tcttggacac      600

atgtgtgatg ccaccatgag ctatgaatgc cctatgctgg atgagggggt ggaaccagat      660

gacgtcgatt gttggtgcaa cacgacgtca acttgggttg tgtacggaac ctgccatcac      720

aaaaaaggtg aagcacggag atctagaaga gctgtgacgc tcccctccca ttccactagg      780

aagctgcaaa cgcggtcgca aacctggttg gaatcaagag aatacacaaa gcacttgatt      840

agagtcgaaa attggatatt caggaaccct ggcttcgcgt tagcagcagc tgccatcgct      900

tggcttttgg gaagctcaac gagccaaaaa gtcatatact tggtcatgat actgctgatt      960

gccccggcat acagcatcag gtgcatagga gtcagcaata gggactttgt ggaaggtatg     1020

tcaggtggga cttgggttga tgttgtcttg gaacatggag gttgtgtcac cgtaatggca     1080

caggacaaac cgactgtcga catagagctg gttacaacaa cagtcagcaa catggcggag     1140

gtaagatcct actgctatga ggcatcaata tcagacatgg cttcggacag ccgctgccca     1200

acacaaggtg aagcctacct tgacaagcaa tcagacactc aatatgtctg caaaagaacg     1260

ttagtggaca gaggctgggg aaatggatgt ggactttttg gcaaagggag tctggtgaca     1320

tgcgctaagt ttgcatgctc caagaaaatg accgggaaga gcatccagcc agagaatctg     1380

gagtaccgga taatgctgtc agttcatggc tcccagcaca gtgggatgat cgttaatgac     1440

acaggacatg aaactgatga gaatagagcg aaggttgaga taacgcccaa ttcaccaaga     1500

gccgaagcca ccctgggggg ttttggaagc ctaggacttg attgtgaacc gaggacaggc     1560

cttgactttt cagatttgta ttacttgact atgaataaca agcactggtt ggttcacaag     1620

gagtggttcc acgacattcc attaccttgg cacgctgggg cagacaccgg aactccacac     1680

tggaacaaca aagaagcact ggtagagttc aaggacgcac atgccaaaag gcaaactgtc     1740

gtggttctag ggagtcaaga aggagcagtt cacacggccc ttgctggagc tctggaggct     1800

gagatggatg gtgcaaaggg aaggctgtcc tctggccact tgaaatgtcg cctgaaaatg     1860

gataaactta gattgaaggg cgtgtcatac tccttgtgta ccgcagcgtt cacattcacc     1920

aagatcccgg ctgaaacact gcacgggaca gtcacagtgg aggtacagta cgcagggaca     1980

gatggacctt gcaaggttcc agctcagatg gcggtggaca tgcaaactct gaccccagtt     2040

gggaggttga taaccgctaa ccccgtaatc actgaaagca ctgagaactc taagatgatg     2100

ctggaacttg atccaccatt tggggactct tacattgtca taggagtcgg ggagaagaag     2160

atcacccacc actggcacag gagtggcagc accattggaa aagcatttga agccactgtg     2220

agaggtgcca agagaatggc agtcttggga gacacagcct gggactttgg atcagttgga     2280

ggcgctctca actcattggg caagggcatc catcaaattt ttggagcagc tttcaaatca     2340

ttgtttggag gaatgtcctg gttctcacaa attctcattg gaacgttgct gatgtggttg     2400

ggtctgaaca caaagaatgg atctatttcc cttatgtgct tggccttagg gggagtgttg     2460

atcttcttat ccacagccgt ctctgctgat gtggggtgct cggtggactt ctcaaagaag     2520

gagacgagat gcggtacagg ggtgttcgtc tataacgacg ttgaagcctg gagggacagg     2580

tacaagtacc atcctgactc cccccgtaga ttggcagcag cagtcaagca agcctgggaa     2640

gatggtatct gcgggatctc ctctgtttca agaatggaaa acatcatgtg gagatcagta     2700

gaaggggagc tcaacgcaat cctggaagag aatggagttc aactgacggt cgttgtggga     2760

tctgtaaaaa accccatgtg gagaggtcca cagagattgc ccgtgcctgt gaacgagctg     2820

ccccacggct ggaaggcttg ggggaaatcg cacttcgtca gagcagcaaa gacaaataac     2880

agctttgtcg tggatggtga cacactgaag gaatgcccac tcaaacatag agcatggaac     2940

agctttcttg tggaggatca tgggttcggg gtatttcaca ctagtgtctg gctcaaggtt     3000

agagaagatt attcattaga gtgtgatcca gccgttattg gaacagctgt taagggaaag     3060

gaggctgtac acagtgatct aggctactgg attgagagtg agaagaatga cacatggagg     3120

ctgaagaggg cccatctgat cgagatgaaa acatgtgaat ggccaaagtc ccacacattg     3180

tggacagatg gaatagaaga gagtgatctg atcataccca agtctttagc tgggccactc     3240

agccatcaca ataccagaga gggctacagg acccaaatga aagggccatg gcacagtgaa     3300

gagcttgaaa ttcggtttga ggaatgccca ggcactaagg tccacgtgga ggaaacatgt     3360

ggaacaagag gaccatctct gagatcaacc actgcaagcg gaagggtgat cgaggaatgg     3420

tgctgcaggg agtgcacaat gcccccactg tcgttccggg ctaaagatgg ctgttggtat     3480

ggaatggaga taaggcccag gaaagaacca gaaagcaact tagtaaggtc aatggtgact     3540

gcaggatcaa ctgatcacat ggatcacttc tcccttggag tgcttgtgat tctgctcatg     3600

gtgcaggaag ggctgaagaa gagaatgacc acaaagatca tcataagcac atcaatggca     3660

gtgctggtag ctatgatcct gggaggattt tcaatgagtg acctggctaa gcttgcaatt     3720

ttgatgggtg ccaccttcgc ggaaatgaac actggaggag atgtagctca tctggcgctg     3780

atagcggcat tcaaagtcag accagcgttg ctggtatctt tcatcttcag agctaattgg     3840

acaccccgtg aaagcatgct gctggccttg gcctcgtgtc ttttgcaaac tgcgatctcc     3900

gccttggaag gcgacctgat ggttctcatc aatggttttg ctttggcctg gttggcaata     3960

cgagcgatgg ttgttccacg cactgataac atcaccttgg caatcctggc tgctctgaca     4020

ccactggccc ggggcacact gcttgtggcg tggagagcag gccttgctac ttgcgggggg     4080

tttatgctcc tctctctgaa gggaaaaggc agtgtgaaga agaacttacc atttgtcatg     4140

gccctgggac taaccgctgt gaggctggtc gaccccatca acgtggtggg gctgctgttg     4200

ctcacaagga gtgggaagcg gagctggccc cctagcgaag tactcacagc tgttggcctg     4260

atatgcgcat tggctggagg gttcgccaag gcagatatag agatggctgg gcccatggcc     4320

gcggtcggtc tgctaattgt cagttacgtg gtctcaggaa agagtgtgga catgtacatt     4380

gaaagagcag gtgacatcac atgggaaaaa gatgcggaag tcactggaaa cagtccccgg     4440

ctcgatgtgg cgctagatga gagtggtgat ttctccctgg tggaggatga cggtcccccc     4500

atgagagaga tcatactcaa ggtggtcctg atgaccatct gtggcatgaa cccaatagcc     4560

ataccctttg cagctggagc gtggtacgta tacgtgaaga ctggaaaaag gagtggtgct     4620

ctatgggatg tgcctgctcc caaggaagta aaaaaggggg agaccacaga tggagtgtac     4680

agagtaatga ctcgtagact gctaggttca acacaagttg gagtgggagt tatgcaagag     4740

ggggtctttc acactatgtg gcacgtcaca aaaggatccg cgctgagaag cggtgaaggg     4800

agacttgatc catactgggg agatgtcaag caggatctgg tgtcatactg tggtccatgg     4860

aagctagatg ccgcctggga cgggcacagc gaggtgcagc tcttggccgt gccccccgga     4920

gagagagcga ggaacatcca gactctgccc ggaatattta agacaaagga tggggacatt     4980

ggagcggttg cgctggatta cccagcagga acttcaggat ctccaatcct agacaagtgt     5040

gggagagtga taggacttta tggcaatggg gtcgtgatca aaaatgggag ttatgttagt     5100

gccatcaccc aagggaggag ggaggaagag actcctgttg agtgcttcga gccttcgatg     5160

ctgaagaaga agcagctaac tgtcttagac ttgcatcctg gagctgggaa aaccaggaga     5220

gttcttcctg aaatagtccg tgaagccata aaaacaagac tccgtactgt gatcttagct     5280

ccaaccaggg ttgtcgctgc tgaaatggag gaagccctta gagggcttcc agtgcgttat     5340

atgacaacag cagtcaatgt cacccactct ggaacagaaa tcgtcgactt aatgtgccat     5400

gccaccttca cttcacgtct actacagcca atcagagtcc ccaactataa tctgtatatt     5460

atggatgagg cccacttcac agatccctca agtatagcag caagaggata catttcaaca     5520

agggttgaga tgggcgaggc ggctgccatc ttcatgaccg ccacgccacc aggaacccgt     5580

gacgcatttc cggactccaa ctcaccaatt atggacaccg aagtggaagt cccagagaga     5640

gcctggagct caggctttga ttgggtgacg gattattctg gaaaaacagt ttggtttgtt     5700

ccaagcgtga ggaacggcaa tgagatcgca gcttgtctga caaaggctgg aaaacgggtc     5760

atacagctca gcagaaagac ttttgagaca gagttccaga aaacaaaaca tcaagagtgg     5820

gactttgtcg tgacaactga catttcagag atgggcgcca actttaaagc tgaccgtgtc     5880

atagattcca ggagatgcct aaagccggtc atacttgatg gcgagagagt cattctggct     5940

ggacccatgc ctgtcacaca tgccagcgct gcccagagga gggggcgcat aggcaggaat     6000

cccaacaaac ctggagatga gtatctgtat ggaggtgggt gcgcagagac tgacgaagac     6060

catgcacact ggcttgaagc aagaatgctc cttgacaata tttacctcca agatggcctc     6120

atagcctcgc tctatcgacc tgaggccgac aaagtagcag ccattgaggg agagttcaag     6180

cttaggacgg agcaaaggaa gacctttgtg gaactcatga aaagaggaga tcttcctgtt     6240

tggctggcct atcaggttgc atctgccgga ataacctaca cagatagaag atggtgcttt     6300

gatggcacga ccaacaacac cataatggaa gacagtgtgc cggcagaggt gtggaccaga     6360

cacggagaga aaagagtgct caaaccgagg tggatggacg ccagagtttg ttcagatcat     6420

gcggccctga agtcattcaa ggagtttgcc gctgggaaaa gaggagcggc ttttggagtg     6480

atggaagccc tgggaacact gccaggacac atgacagaga gattccagga agccattgac     6540

aacctcgctg tgctcatgcg ggcagagact ggaagcaggc cttacaaagc cgcggcggcc     6600

caattgccgg agaccctaga gaccattatg cttttggggt tgctgggaac agtctcgctg     6660

ggaatctttt tcgtcttgat gaggaacaag ggcataggga agatgggctt tggaatggtg     6720

actcttgggg ccagcgcatg gctcatgtgg ctctcggaaa ttgagccagc cagaattgca     6780

tgtgtcctca ttgttgtgtt cctattgctg gtggtgctca tacctgagcc agaaaagcaa     6840

agatctcccc aggacaacca aatggcaatc atcatcatgg tagcagtagg tcttctgggc     6900

ttgattaccg ccaatgaact cggatggttg gagagaacaa agagtgacct aagccatcta     6960

atgggaagga gagaggaggg ggcaaccatg ggattctcaa tggacattga cctgcggcca     7020

gcctcagctt gggccatcta tgctgccttg acaactttca ttaccccagc cgtccaacat     7080

gcagtgacca cttcatacaa caactactcc ttaatggcga tggccacgca agctggagtg     7140

ttgtttggta tgggcaaagg gatgccattc tacgcatggg actttggagt cccgctgcta     7200

atgataggtt gctactcaca attaacgccc ctgaccctaa tagtggccat cattttgctc     7260

gtggcgcact acatgtactt gatcccaggg ctgcaggcag cagctgcgcg tgctgcccag     7320

aagagaacgg cagctggcat catgaagaac cctgttgtgg atggaatagt ggtgactgac     7380

attgacacaa tgacaattga cccccaagtg gagaaaaaga tgggacaggt gctactcatg     7440

gcagtagccg tctccagcgc catactgtcg cggaccgcct gggggtgggg ggaggctggg     7500

gccctgatca cagccgcaac ttccactttg tgggaaggct ctccgaacaa gtactggaac     7560

tcctctacag ccacttcact gtgtaacatt tttaggggaa gttacttggc tggagcttct     7620

ctaatctaca cagtaacaag aaacgctggc ttggtcaaga gacgtggggg tggaacagga     7680

gagaccctgg gagagaaatg gaaggcccgc ttgaaccaga tgtcggccct ggagttctac     7740

tcctacaaaa agtcaggcat caccgaggtg tgcagagaag aggcccgccg cgccctcaag     7800

gacggtgtgg caacgggagg ccatgctgtg tcccgaggaa gtgcaaagct gagatggttg     7860

gtggagcggg gatacctgca gccctatgga aaggtcattg atcttggatg tggcagaggg     7920

ggctggagtt actacgccgc caccatccgc aaagttcaag aagtgaaagg atacacaaaa     7980

ggaggccctg gtcatgaaga acccgtgttg gtgcaaagct atgggtggaa catagtccgt     8040

cttaagagtg gggtggacgt ctttcatatg gcggctgagc cgtgtgacac gttgctgtgt     8100

gacataggtg agtcatcatc tagtcctgaa gtggaagaag cacggacgct cagagtcctc     8160

tccatggtgg gggattggct tgaaaaaaga ccaggagcct tttgtataaa agtgttgtgc     8220

ccatacacca gcactatgat ggaaaccctg gagcgactgc agcgtaggta tgggggagga     8280

ctggtcagag tgccactctc ccgcaactct acacatgaga tgtactgggt ctctggagcg     8340

aaaagcaaca ccataaaaag tgtgtccacc acgagccagc tcctcttggg gcgcatggac     8400

gggcctagga ggccagtgaa atatgaggag gatgtgaatc tcggctctgg cacgcgggct     8460

gtggtaagct gcgctgaagc tcccaacatg aagatcattg gtaaccgcat tgaaaggatc     8520

cgcagtgagc acgcggaaac gtggttcttt gacgagaacc acccatatag gacatgggct     8580

taccatggaa gctatgaggc ccccacacaa gggtcagcgt cctctctaat aaacggggtt     8640

gtcaggctcc tgtcaaaacc ctgggatgtg gtgactggag tcacaggaat agccatgacc     8700

gacaccacac cgtatggtca gcaaagagtt ttcaaggaaa aagtggacac tagggtgcca     8760

gacccccaag aaggcactcg tcaggttatg agcatggtct cttcctggtt gtggaaagag     8820

ctaggcaaac acaaacggcc acgagtctgt accaaagaag agttcatcaa caaggttcgt     8880

agcaatgcag cattaggggc aatatttgaa gaggaaaaag agtggaagac tgcagtggaa     8940

gctgtgaacg atccaaggtt ctgggctcta gtggacaagg aaagagagca ccacctgaga     9000

ggagagtgcc agagttgtgt gtacaacatg atgggaaaaa gagaaaagaa acaaggggaa     9060

tttggaaagg ccaagggcag ccgcgccatc tggtatatgt ggctaggggc tagatttcta     9120

gagttcgaag cccttggatt cttgaacgag gatcactgga tggggagaga gaactcagga     9180

ggtggtgttg aagggctggg attacaaaga ctcggatatg tcctagaaga gatgagtcgc     9240

ataccaggag gaaggatgta tgcagatgac actgctggct gggacacccg catcagcagg     9300

tttgatctgg agaatgaagc tctaatcacc aaccaaatgg agaaagggca cagggccttg     9360

gcattggcca taatcaagta cacataccaa aacaaagtgg taaaggtcct tagaccagct     9420

gaaaaaggga agacagttat ggacattatt tcgagacaag accaaagggg gagcggacaa     9480

gttgtcactt acgctcttaa cacatttacc aacctagtgg tgcaactcat tcggaatatg     9540

gaggctgagg aagttctaga gatgcaagac ttgtggctgc tgcggaggtc agagaaagtg     9600

accaactggt tgcagagcaa cggatgggat aggctcaaac gaatggcagt cagtggagat     9660

gattgcgttg tgaagccaat tgatgatagg tttgcacatg ccctcaggtt cttgaatgat     9720

atgggaaaag ttaggaagga cacacaagag tggaaaccct caactggatg ggacaactgg     9780

gaagaagttc cgttttgctc ccaccacttc aacaagctcc atctcaagga cgggaggtcc     9840

attgtggttc cctgccgcca ccaagatgaa ctgattggcc gggcccgcgt ctctccaggg     9900

gcgggatgga gcatccggga gactgcttgc ctagcaaaat catatgcgca aatgtggcag     9960

ctcctttatt tccacagaag ggacctccga ctgatggcca atgccatttg ttcatctgtg    10020

ccagttgact gggttccaac tgggagaact acctggtcaa tccatggaaa gggagaatgg    10080

atgaccactg aagacatgct tgtggtgtgg aacagagtgt ggattgagga gaacgaccac    10140

atggaagaca agaccccagt tacgaaatgg acagacattc cctatttggg aaaaagggaa    10200

gacttgtggt gtggatctct catagggcac agaccgcgca ccacctgggc tgagaacatt    10260

aaaaacacag tcaacatggt gcgcaggatc ataggtgatg aagaaaagta catggactac    10320

ctatccaccc aagttcgcta cttgggtgaa gaagggtcta cacctggagt gctgtaagca    10380

ccaatcttaa tgttgtcagg cctgctagtc agccacagct tggggaaagc tgtgcagcct    10440

gtgacccccc caggagaagc tgggaaacca agcctatagt caggccgaga acgccatggc    10500

acggaagaag ccatgctgcc tgtgagcccc tcagaggaca ctgagtcaaa aaaccccacg    10560

cgcttggagg cgcaggatgg gaaaagaagg tggcgacctt ccccaccctt caatctgggg    10620

cctgaactgg agatcagctg tggatctcca gaagagggac tagtggttag aggaga        10676


<210>  5
<211>  10675
<212>  DNA
<213>  Zika virus strain PRVABC59

<400>  5
gttgttgatc tgtgtgaatc agactgcgac agttcgagtt tgaagcgaaa gctagcaaca       60

gtatcaacag gttttatttt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

aaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtgag      180

cccctttggg ggcttgaaga ggctgccagc cggacttctg ctgggtcatg ggcccatcag      240

gatggtcttg gcgattctag cctttttgag attcacggca atcaagccat cactgggtct      300

catcaataga tggggttcag tggggaaaaa agaggctatg gaaacaataa agaagttcaa      360

gaaagatctg gctgccatgc tgagaataat caatgctagg aaggagaaga agagacgagg      420

cgcagatact agtgtcggaa ttgttggcct cctgctgacc acagctatgg cagcggaggt      480

cactagacgt gggagtgcat actatatgta cttggacaga aacgatgctg gggaggccat      540

atcttttcca accacattgg ggatgaataa gtgttatata cagatcatgg atcttggaca      600

catgtgtgat gccaccatga gctatgaatg ccctatgctg gatgaggggg tggaaccaga      660

tgacgtcgat tgttggtgca acacgacgtc aacttgggtt gtgtacggaa cctgccatca      720

caaaaaaggt gaagcacgga gatctagaag agctgtgacg ctcccctccc attccaccag      780

gaagctgcaa acgcggtcgc aaacctggtt ggaatcaaga gaatacacaa agcacttgat      840

tagagtcgaa aattggatat tcaggaaccc tggcttcgcg ttagcagcag ctgccatcgc      900

ttggcttttg ggaagctcaa cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagcatca ggtgcatagg agtcagcaat agggactttg tggaaggtat     1020

gtcaggtggg acttgggttg atgttgtctt ggaacatgga ggttgtgtca ccgtaatggc     1080

acaggacaaa ccgactgtcg acatagagct ggttacaaca acagtcagca acatggcgga     1140

ggtaagatcc tactgctatg aggcatcaat atcagacatg gcttctgaca gccgctgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

gttagtggac agaggctggg gaaatggatg tggacttttt ggcaaaggga gcctggtgac     1320

atgcgctaag tttgcatgct ccaagaaaat gaccgggaag agcatccagc cagagaatct     1380

ggagtaccgg ataatgctgt cagttcatgg ctcccagcac agtgggatga tcgttaatga     1440

cacaggacat gaaactgatg agaatagagc gaaagttgag ataacgccca attcaccgag     1500

agccgaagcc accctggggg gttttggaag cctaggactt gattgtgaac cgaggacagg     1560

ccttgacttt tcagatttgt attacttgac tatgaataac aagcactggt tggttcacaa     1620

ggagtggttc cacgacattc cattaccttg gcacgctggg gcagacaccg gaactccaca     1680

ctggaacaac aaagaagcac tggtagagtt caaggacgca catgccaaaa ggcaaactgt     1740

cgtggttcta gggagtcaag aaggagcagt tcacacggcc cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaagg gaaggctgtc ctctggccac ttgaaatgtc gcctgaaaat     1860

ggataaactt agattgaagg gcgtgtcata ctccttgtgt actgcagcgt tcacattcac     1920

caagatcccg gctgaaacac tgcacgggac agtcacagtg gaggtacagt acgcagggac     1980

agatggacct tgcaaggttc cagctcagat ggcggtggac atgcaaactc tgaccccagt     2040

tgggaggttg ataaccgcta accccgtaat cactgaaagc actgagaact ctaagatgat     2100

gctggaactt gatccaccat ttggggactc ttacattgtc ataggagtcg gggagaagaa     2160

gatcacccac cactggcaca ggagtggcag caccattgga aaagcatttg aagccactgt     2220

gagaggtgcc aagagaatgg cagtcttggg agacacagcc tgggactttg gatcagttgg     2280

aggcgctctc aactcattgg gcaagggcat ccatcaaatt tttggagcag ctttcaaatc     2340

attgtttgga ggaatgtcct ggttctcaca aattctcatt ggaacgttgc tgatgtggtt     2400

gggtctgaac acaaagaatg gatctatttc ccttatgtgc ttggccttag ggggagtgtt     2460

gatcttctta tccacagccg tctctgctga tgtggggtgc tcggtggact tctcaaagaa     2520

ggagacgaga tgcggtacag gggtgttcgt ctataacgac gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgtag attggcagca gcagtcaagc aagcctggga     2640

agatggtatc tgcgggatct cctctgtttc aagaatggaa aacatcatgt ggagatcagt     2700

agaaggggag ctcaacgcaa tcctggaaga gaatggagtt caactgacgg tcgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acagagattg cccgtgcctg tgaacgagct     2820

gccccacggc tggaaggctt gggggaaatc gtatttcgtc agagcagcaa agacaaataa     2880

cagctttgtc gtggatggtg acacactgaa ggaatgccca ctcaaacata gagcatggaa     2940

cagctttctt gtggaggatc atgggttcgg ggtatttcac actagtgtct ggctcaaggt     3000

tagagaagat tattcattag agtgtgatcc agccgttatt ggaacagctg ttaagggaaa     3060

ggaggctgta cacagtgatc taggctactg gattgagagt gagaagaatg acacatggag     3120

gctgaagagg gcccatctga tcgagatgaa aacatgtgaa tggccaaagt cccacacatt     3180

gtggacagat ggaatagaag agagtgatct gatcataccc aagtctttag ctgggccact     3240

cagccatcac aataccagag agggctacag gacccaaatg aaagggccat ggcacagtga     3300

agagcttgaa attcggtttg aggaatgccc aggcactaag gtccacgtgg aggaaacatg     3360

tggaacaaga ggaccatctc tgagatcaac cactgcaagc ggaagggtga tcgaggaatg     3420

gtgctgcagg gagtgcacaa tgcccccact gtcgttccgg gctaaagatg gctgttggta     3480

tggaatggag ataaggccca ggaaagaacc agaaagcaac ttagtaaggt caatggtgac     3540

tgcaggatca actgatcaca tggaccactt ctcccttgga gtgcttgtga tcctgctcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc atcataagca catcaatggc     3660

agtgctggta gctatgatcc tgggaggatt ttcaatgagt gacctggcta agcttgcaat     3720

tttgatgggt gccaccttcg cggaaatgaa cactggagga gatgtagctc atctggcgct     3780

gatagcggca ttcaaagtca gaccagcgtt gctggtatct ttcatcttca gagctaattg     3840

gacaccccgt gaaagcatgc tgctggcctt ggcctcgtgt cttttgcaaa ctgcgatctc     3900

cgccttggaa ggcgacctga tggttctcat caatggtttt gctttggcct ggttggcaat     3960

acgagcgatg gttgttccac gcactgataa catcaccttg gcaatcctgg ctgctctgac     4020

accactggcc cggggcacac tgcttgtggc gtggagagca ggccttgcta cttgcggggg     4080

gtttatgctc ctctctctga agggaaaagg cagtgtgaag aagaacttac catttgtcat     4140

ggccctggga ctaaccgctg tgaggctggt cgaccccatc aacgtggtgg gactgctgtt     4200

gctcacaagg agtgggaagc ggagctggcc ccctagcgaa gtactcacag ctgttggcct     4260

gatatgcgca ttggctggag ggttcgccaa ggcagatata gagatggctg ggcccatggc     4320

cgcggtcggt ctgctaattg tcagttacgt ggtctcagga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa agatgcggaa gtcactggaa acagtccccg     4440

gctcgatgtg gcgctagatg agagtggtga tttctccctg gtggaggatg acggtccccc     4500

catgagagag atcatactca aggtggtcct gatgaccatc tgtggcatga acccaatagc     4560

catacccttt gcagctggag cgtggtacgt atacgtgaag actggaaaaa ggagtggtgc     4620

tctatgggat gtgcctgctc ccaaggaagt aaaaaagggg gagaccacag atggagtgta     4680

cagagtaatg actcgtagac tgctaggttc aacacaagtt ggagtgggag ttatgcaaga     4740

gggggtcttt cacactatgt ggcacgtcac aaaaggatcc gcgctgagaa gcggtgaagg     4800

gagacttgat ccatactggg gagatgtcaa gcaggatctg gtgtcatact gtggtccatg     4860

gaagctagat gccgcctggg atgggcacag cgaggtgcag ctcttggccg tgccccccgg     4920

agagagagcg aggaacatcc agactctgcc cggaatattt aagacaaagg atggggacat     4980

tggagcggtt gcgctggatt acccagcagg aacttcagga tctccaatcc tagacaagtg     5040

tgggagagtg ataggacttt atggcaatgg ggtcgtgatc aaaaacggga gttatgttag     5100

tgccatcacc caagggagga gggaggaaga gactcctgtt gagtgcttcg agccctcgat     5160

gctgaagaag aagcagctaa ctgtcttaga cttgcatcct ggagctggga aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaacaaga ctccgtactg tgatcttagc     5280

tccaaccagg gttgtcgctg ctgaaatgga ggaggccctt agagggcttc cagtgcgtta     5340

tatgacaaca gcagtcaatg tcacccactc tggaacagaa atcgtcgact taatgtgcca     5400

tgccaccttc acttcacgtc tactacagcc aatcagagtc cccaactata atctgtatat     5460

tatggatgag gcccacttca cagatccctc aagtatagca gcaagaggat acatttcaac     5520

aagggttgag atgggcgagg cggctgccat cttcatgacc gccacgccac caggaacccg     5580

tgacgcattt ccggactcca actcaccaat tatggacacc gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac ggatcattct ggaaaaacag tttggtttgt     5700

tccaagcgtg aggaacggca atgagatcgc agcttgtctg acaaaggctg gaaaacgggt     5760

catacagctc agcagaaaga cttttgagac agagttccag aaaacaaaac atcaagagtg     5820

ggactttgtc gtgacaactg acatttcaga gatgggcgcc aactttaaag ctgaccgtgt     5880

catagattcc aggagatgcc taaagccggt catacttgat ggcgagagag tcattctggc     5940

tggacccatg cctgtcacac atgccagcgc tgcccagagg agggggcgca taggcaggaa     6000

tcccaacaaa cctggagatg agtatctgta tggaggtggg tgcgcagaga ctgacgaaga     6060

ccatgcacac tggcttgaag caagaatgct ccttgacaat atttacctcc aagatggcct     6120

catagcctcg ctctatcgac ctgaggccga caaagtagca gccattgagg gagagttcaa     6180

gcttaggacg gagcaaagga agacctttgt ggaactcatg aaaagaggag atcttcctgt     6240

ttggctggcc tatcaggttg catctgccgg aataacctac acagatagaa gatggtgctt     6300

tgatggcacg accaacaaca ccataatgga agacagtgtg ccggcagagg tgtggaccag     6360

acacggagag aaaagagtgc tcaaaccgag gtggatggac gccagagttt gttcagatca     6420

tgcggccctg aagtcattca aggagtttgc cgctgggaaa agaggagcgg cttttggagt     6480

gatggaagcc ctgggaacac tgccaggaca catgacagag agattccagg aagccattga     6540

caacctcgct gtgctcatgc gggcagagac tggaagcagg ccttacaaag ccgcggcggc     6600

ccaattgccg gagaccctag agaccataat gcttttgggg ttgctgggaa cagtctcgct     6660

gggaatcttc ttcgtcttga tgaggaacaa gggcataggg aagatgggct ttggaatggt     6720

gactcttggg gccagcgcat ggctcatgtg gctctcggaa attgagccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcctattgct ggtggtgctc atacctgagc cagaaaagca     6840

aagatctccc caggacaacc aaatggcaat catcatcatg gtagcagtag gtcttctggg     6900

cttgattacc gccaatgaac tcggatggtt ggagagaaca aagagtgacc taagccatct     6960

aatgggaagg agagaggagg gggcaaccat aggattctca atggacattg acctgcggcc     7020

agcctcagct tgggccatct atgctgcctt gacaactttc attaccccag ccgtccaaca     7080

tgcagtgacc acctcataca acaactactc cttaatggcg atggccacgc aagctggagt     7140

gttgtttggc atgggcaaag ggatgccatt ctacgcatgg gactttggag tcccgctgct     7200

aatgataggt tgctactcac aattaacacc cctgacccta atagtggcca tcattttgct     7260

cgtggcgcac tacatgtact tgatcccagg gctgcaggca gcagctgcgc gtgctgccca     7320

gaagagaacg gcagctggca tcatgaagaa ccctgttgtg gatggaatag tggtgactga     7380

cattgacaca atgacaattg acccccaagt ggagaaaaag atgggacagg tgctactcat     7440

agcagtagcc gtctccagcg ccatactgtc gcggaccgcc tgggggtggg gggaggctgg     7500

ggctctgatc acagccgcaa cttccacttt gtgggaaggc tctccgaaca agtactggaa     7560

ctcctctaca gccacttcac tgtgtaacat ttttagggga agttacttgg ctggagcttc     7620

tctaatctac acagtaacaa gaaacgctgg cttggtcaag agacgtgggg gtggaacagg     7680

agagaccctg ggagagaaat ggaaggcccg cttgaaccag atgtcggccc tggagttcta     7740

ctcctacaaa aagtcaggca tcaccgaggt gtgcagagaa gaggcccgcc gcgccctcaa     7800

ggacggtgtg gcaacgggag gccatgctgt gtcccgagga agtgcaaagc tgagatggtt     7860

ggtggagcgg ggatacctgc agccctatgg aaaggtcatt gatcttggat gtggcagagg     7920

gggctggagt tactacgtcg ccaccatccg caaagttcaa gaagtgaaag gatacacaaa     7980

aggaggccct ggtcatgaag aacccgtgtt ggtgcaaagc tatgggtgga acatagtccg     8040

tcttaagagt ggggtggacg tctttcatat ggcggctgag ccgtgtgaca cgttgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagaa gcacggacgc tcagagtcct     8160

ctccatggtg ggggattggc ttgaaaaaag accaggagcc ttttgtataa aagtgttgtg     8220

cccatacacc agcactatga tggaaaccct ggagcgactg cagcgtaggt atgggggagg     8280

actggtcaga gtgccactct cccgcaactc tacacatgag atgtactggg tctctggagc     8340

gaaaagcaac accataaaaa gtgtgtccac cacgagccag ctcctcttgg ggcgcatgga     8400

cgggcctagg aggccagtga aatatgagga ggatgtgaat ctcggctctg gcacgcgggc     8460

tgtggtaagc tgcgctgaag ctcccaacat gaagatcatt ggtaaccgca ttgaaaggat     8520

ccgcagtgag cacgcggaaa cgtggttctt tgacgagaac cacccatata ggacatgggc     8580

ttaccatgga agctatgagg cccccacaca agggtcagcg tcctctctaa taaacggggt     8640

tgtcaggctc ctgtcaaaac cctgggatgt ggtgactgga gtcacaggaa tagccatgac     8700

cgacaccaca ccgtatggtc agcaaagagt tttcaaggaa aaagtggaca ctagggtgcc     8760

agacccccaa gaaggcactc gtcaggttat gagcatggtc tcttcctggt tgtggaaaga     8820

gctaggcaaa cacaaacggc cacgagtctg caccaaagaa gagttcatca acaaggttcg     8880

tagcaatgca gcattagggg caatatttga agaggaaaaa gagtggaaga ctgcagtgga     8940

agctgtgaac gatccaaggt tctgggctct agtggacaag gaaagagagc accacctgag     9000

aggagagtgc cagagctgtg tgtacaacat gatgggaaaa agagaaaaga aacaagggga     9060

atttggaaag gccaagggca gccgcgccat ctggtatatg tggctagggg ctagatttct     9120

agagttcgaa gcccttggat tcttgaacga ggatcactgg atggggagag agaactcagg     9180

aggtggtgtt gaagggctgg gattacaaag actcggatat gtcctagaag agatgagtcg     9240

tataccagga ggaaggatgt atgcagatga cactgctggc tgggacaccc gcattagcag     9300

gtttgatctg gagaatgaag ctctaatcac caaccaaatg gagaaagggc acagggcctt     9360

ggcattggcc ataatcaagt acacatacca aaacaaagtg gtaaaggtcc ttagaccagc     9420

tgaaaaaggg aaaacagtta tggacattat ttcgagacaa gaccaaaggg ggagcggaca     9480

agttgtcact tacgctctta acacatttac caacctagtg gtgcaactca ttcggaatat     9540

ggaggctgag gaagttctag agatgcaaga cttgtggctg ctgcggaggt cagagaaagt     9600

gaccaactgg ttgcagagca acggatggga taggctcaaa cgaatggcag tcagtggaga     9660

tgattgcgtt gtgaagccaa ttgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

tatgggaaaa gttaggaagg acacacaaga gtggaaaccc tcaactggat gggacaactg     9780

ggaagaagtt ccgttttgct cccaccactt caacaagctc catctcaagg acgggaggtc     9840

cattgtggtt ccctgccgcc accaagatga actgattggc cgggcccgcg tctctccagg     9900

ggcgggatgg agcatccggg agactgcttg cctagcaaaa tcatatgcgc aaatgtggca     9960

gctcctttat ttccacagaa gggacctccg actgatggcc aatgccattt gttcatctgt    10020

gccagttgac tgggttccaa ctgggagaac tacctggtca atccatggaa agggagaatg    10080

gatgaccact gaagacatgc ttgtggtgtg gaacagagtg tggattgagg agaacgacca    10140

catggaagac aagaccccag ttacgaaatg gacagacatt ccctatttgg gaaaaaggga    10200

agacttgtgg tgtggatctc tcatagggca cagaccgcgc accacctggg ctgagaacat    10260

taaaaacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

cctatccacc caagttcgct acttgggtga agaagggtct acacctggag tgctgtaagc    10380

accaatctta atgttgtcag gcctgctagt cagccacagc ttggggaaag ctgtgcagcc    10440

tgtgaccccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatctcc agaagaggga ctagtggtta gagga         10675


<210>  6
<211>  10807
<212>  DNA
<213>  Zika virus genomic RNA, complete genome, strain: MR766-NIID

<400>  6
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa      180

ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag      240

aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct      300

tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa      360

gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg      420

cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat      480

cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat      540

ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca      600

catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga      660

tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca      720

caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag      780

gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat      840

caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc      900

ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat     1020

gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc     1080

acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga     1140

ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac     1320

atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct     1380

ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ctgtcaatga     1440

tataggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag     1500

agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg     1560

ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa     1620

agagtggttt catgacatcc cattgccttg gcatgctggg gcagacactg gaactccaca     1680

ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt     1740

cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc     1800

tgagatggat ggtgcaaagg gaaagctgtt ctctggccat ttgaaatgcc gcctaaaaat     1860

ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac     1920

caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac     1980

agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt     2040

tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat     2100

gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa     2160

aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt     2220

gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg     2280

gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc     2340

actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt     2400

aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat     2460

gatcttcctc tccacggctg tttctgctga cgtggggtgc tcagtggact tctcaaaaaa     2520

ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg     2580

gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga     2640

agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt     2700

agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct     2820

gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa     2880

cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa     2940

tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt     3000

cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag     3060

ggaggccgcg cacagtgatc tgggctattg gattgaaagt gaaaagaatg acacatggag     3120

gctgaagagg gcccacctga ttgagatgaa aacatgtgaa tggccaaagt ctcacacatt     3180

gtggacagat ggagtagaag aaagtgatct tatcataccc aagtctttag ctggtccact     3240

cagccaccac aacaccagag agggttacag aacccaagtg aaagggccat ggcacagtga     3300

agagcttgaa atccggtttg aggaatgtcc aggcaccaag gtttacgtgg aggagacatg     3360

cggaactaga ggaccatctc tgagatcaac tactgcaagt ggaagggtca ttgaggaatg     3420

gtgctgtagg gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta     3480

tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac     3540

agcggggtca accgatcata tggaccactt ctctcttgga gtgcttgtga ttctactcat     3600

ggtgcaggag gggttgaaga agagaatgac cacaaagatc atcatgagca catcaatggc     3660

agtgctggta gtcatgatct tgggaggatt ttcaatgagt gacctggcca agcttgtgat     3720

cctgatgggt gctactttcg cagaaatgaa cactggagga gatgtagctc acttggcatt     3780

ggtagcggca tttaaagtca gaccagcctt gctggtctcc ttcattttca gagccaattg     3840

gacaccccgt gagagcatgc tgctagccct ggcttcgtgt cttctgcaaa ctgcgatctc     3900

tgctcttgaa ggtgacttga tggtcctcat taatggattt gctttggcct ggttggcaat     3960

tcgagcaatg gccgtgccac gcactgacaa catcgctcta ccaatcttgg ctgctctaac     4020

accactagct cgaggcacac tgctcgtggc atggagagcg ggcctggcta cttgtggagg     4080

gatcatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat     4140

ggccctggga ttgacagctg tgagggtagt agaccctatt aatgtggtag gactactgtt     4200

actcacaagg agtgggaagc ggagctggcc ccctagtgaa gttctcacag ccgttggcct     4260

gatatgtgca ctggccggag ggtttgccaa ggcagacatt gagatggctg gacccatggc     4320

tgcagtaggc ttgctaattg tcagctatgt ggtctcggga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gtcactggaa acagtcctcg     4440

gcttgacgtg gcactggatg agagtggtga tttctccttg gtagaggaag atggtccacc     4500

catgagagag atcatactta aggtggtcct gatggccatc tgtggcatga acccaatagc     4560

tatacctttt gctgcaggag cgtggtatgt gtatgtgaag actgggaaaa ggagtggcgc     4620

cctctgggac gtgcctgctc ccaaagaagt gaagaaagga gagaccacag atggagtgta     4680

cagagtgatg actcgcagac tgctaggttc aacacaggtt ggagtgggag tcatgcaaga     4740

gggagtcttc cacaccatgt ggcacgttac aaaaggagcc gcactgagga gcggtgaggg     4800

aagacttgat ccatactggg gggatgtcaa gcaggacttg gtgtcatact gtgggccttg     4860

gaagttggat gcagcttggg atggactcag cgaggtacag cttttggccg tacctcccgg     4920

agagagggcc agaaacattc agaccctgcc tggaatattc aagacaaagg acggggacat     4980

cggagcagtt gctctggact accctgcagg gacctcagga tctccgatcc tagacaaatg     5040

tggaagagtg ataggactct atggcaatgg ggttgtgatc aagaatggaa gctatgttag     5100

tgctataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat     5160

gctgaagaag aagcagctaa ctgtcttgga tctgcatcca ggagccggaa aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccggacag tgatcttggc     5280

accaactagg gttgtcgctg ctgagatgga ggaggccttg agaggacttc cggtgcgtta     5340

catgacaaca gcagtcaacg tcacccattc tgggacagaa atcgttgatt tgatgtgcca     5400

tgccactttc acttcacgct tactacaacc catcagagtc cctaattaca atctctacat     5460

catggatgaa gcccacttca cagacccctc aagtatagct gcaagaggat atatatcaac     5520

aagggttgaa atgggcgagg cggctgccat ttttatgact gccacaccac caggaacccg     5580

tgatgcgttt cctgactcta actcaccaat catggacaca gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt     5700

tccaagcgtg agaaacggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt     5760

catacagctc agcaggaaga cttttgagac agaatttcag aaaacaaaaa atcaagagtg     5820

ggactttgtc ataacaactg acatctcaga gatgggcgcc aacttcaagg ctgaccgggt     5880

catagactct aggagatgcc taaaaccagt catacttgat ggtgagagag tcatcttggc     5940

tgggcccatg cctgtcacgc atgctagtgc tgctcagagg agaggacgta taggcaggaa     6000

ccctaacaaa cctggagatg agtacatgta tggaggtggg tgtgcagaga ctgatgaagg     6060

ccatgcacac tggcttgaag caagaatgct tcttgacaac atctacctcc aggatggcct     6120

catagcctcg ctctatcggc ctgaggccga taaggtagcc gccattgagg gagagtttaa     6180

gctgaggaca gagcaaagga agaccttcgt ggaactcatg aagagaggag accttcccgt     6240

ctggctagcc tatcaggttg catctgccgg aataacttac acagacagaa gatggtgctt     6300

tgatggcaca accaacaaca ccataatgga agacagcgta ccagcagagg tgtggacaaa     6360

gtatggagag aagagagtgc tcaaaccgag atggatggat gctagggtct gttcagacca     6420

tgcggccctg aagtcgttca aagaattcgc cgctggaaaa agaggagcgg ctttgggagt     6480

aatggaggcc ctgggaacac tgccaggaca catgacagag aggtttcagg aagccattga     6540

caacctcgcc gtgctcatgc gagcagagac tggaagcagg ccttataagg cagcggcagc     6600

ccaactgccg gagaccctag agaccattat gctcttaggt ttgctgggaa cagtttcact     6660

ggggatcttc ttcgtcttga tgcggaataa gggcatcggg aagatgggct ttggaatggt     6720

aacccttggg gccagtgcat ggctcatgtg gctttcggaa attgaaccag ccagaattgc     6780

atgtgtcctc attgttgtgt ttttattact ggtggtgctc atacccgagc cagagaagca     6840

aagatctccc caagataacc agatggcaat tatcatcatg gtggcagtgg gccttctagg     6900

tttgataact gcaaacgaac ttggatggct ggaaagaaca aaaaatgaca tagctcatct     6960

aatgggaagg agagaagaag gagcaaccat gggattctca atggacattg atctgcggcc     7020

agcctccgcc tgggctatct atgccgcatt gacaactctc atcaccccag ctgtccaaca     7080

tgcggtaacc acttcataca acaactactc cttaatggcg atggccacac aagctggagt     7140

gctgtttggc atgggcaaag ggatgccatt ttatgcatgg gaccttggag tcccgctgct     7200

aatgatgggt tgctattcac aattaacacc cctgactctg atagtagcta tcattctgct     7260

tgtggcgcac tacatgtact tgatcccagg cctacaagcg gcagcagcgc gtgctgccca     7320

gaaaaggaca gcagctggca tcatgaagaa tcccgttgtg gatggaatag tggtaactga     7380

cattgacaca atgacaatag acccccaggt ggagaagaag atgggacaag tgttactcat     7440

agcagtagcc atctccagtg ctgtgctgct gcggaccgcc tggggatggg gggaggctgg     7500

agctctgatc acagcagcga cctccacctt gtgggaaggc tctccaaaca aatactggaa     7560

ctcctctaca gccacctcac tgtgcaacat cttcagagga agctatctgg caggagcttc     7620

ccttatctat acagtgacga gaaacgctgg cctggttaag agacgtggag gtgggacggg     7680

agagactctg ggagagaagt ggaaagctcg tctgaatcag atgtcggccc tggagttcta     7740

ctcttataaa aagtcaggta tcactgaagt gtgtagagag gaggctcgcc gtgccctcaa     7800

ggatggagtg gccacaggag gacatgccgt atcccgggga agtgcaaagc tcagatggtt     7860

ggtggagaga ggatatctgc agccctatgg gaaggttgtt gacctcggat gtggcagagg     7920

gggctggagc tattatgccg ccaccatccg caaagtgcag gaggtgagag gatacacaaa     7980

gggaggtccc ggtcatgaag aacccatgct ggtgcaaagc tatgggtgga acatagttcg     8040

tctcaagagt ggagtggacg tcttccacat ggcggctgag ccgtgtgaca ctctgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagag acacgaacac tcagagtgct     8160

ctctatggtg ggggactggc ttgaaaaaag accaggggcc ttctgtataa aggtgctgtg     8220

cccatacacc agcactatga tggaaaccat ggagcgactg caacgtaggc atgggggagg     8280

attagtcaga gtgccattgt ctcgcaactc cacacatgag atgtactggg tctctggggc     8340

aaagagcaac atcataaaaa gtgtgtccac cacaagtcag ctcctcctgg gacgcatgga     8400

tggccccagg aggccagtga aatatgagga ggatgtgaac ctcggctcgg gtacacgagc     8460

tgtggcaagc tgtgctgagg ctcctaacat gaaaatcatc ggcaggcgca ttgagagaat     8520

ccgcaatgaa catgcagaaa catggtttct tgatgaaaac cacccataca ggacatgggc     8580

ctaccatggg agctacgaag cccccacgca aggatcagcg tcttccctcg tgaacggggt     8640

tgttagactc ctgtcaaagc cttgggacgt ggtgactgga gttacaggaa tagccatgac     8700

tgacaccaca ccatacggcc aacaaagagt cttcaaagaa aaagtggaca ccagggtgcc     8760

agatccccaa gaaggcactc gccaggtaat gaacatagtc tcttcctggc tgtggaagga     8820

gctggggaaa cgcaagcggc cacgcgtctg caccaaagaa gagtttatca acaaggtgcg     8880

cagcaatgca gcactgggag caatatttga agaggaaaaa gaatggaaga cggctgtgga     8940

agctgtgaat gatccaaggt tttgggccct agtggatagg gagagagaac accacctgag     9000

aggagagtgt cacagctgtg tgtacaacat gatgggaaaa agagaaaaga agcaaggaga     9060

gttcgggaaa gcaaaaggta gccgcgccat ctggtacatg tggttgggag ccagattctt     9120

ggagtttgaa gcccttggat tcttgaacga ggaccattgg atgggaagag aaaactcagg     9180

aggtggagtc gaagggttag gattgcaaag acttggatac attctagaag aaatgaatcg     9240

ggcaccagga ggaaagatgt acgcagatga cactgctggc tgggacaccc gcattagtaa     9300

gtttgatctg gagaatgaag ctctgattac caaccaaatg gaggaagggc acagaactct     9360

ggcgttggcc gtgattaaat acacatacca aaacaaagtg gtgaaggttc tcagaccagc     9420

tgaaggagga aaaacagtta tggacatcat ttcaagacaa gaccagagag ggagtggaca     9480

agttgtcact tatgctctca acacattcac caacttggtg gtgcagctta tccggaacat     9540

ggaagctgag gaagtgttag agatgcaaga cttatggttg ttgaggaagc cagagaaagt     9600

gaccagatgg ttgcagagca atggatggga tagactcaaa cgaatggcgg tcagtggaga     9660

tgactgcgtt gtgaagccaa tcgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

catgggaaaa gttaggaaag acacacagga gtggaaaccc tcgactggat ggagcaattg     9780

ggaagaagtc ccgttctgct cccaccactt caacaagctg tacctcaagg atgggagatc     9840

cattgtggtc ccttgccgcc accaagatga actgattggc cgagctcgcg tctcaccagg     9900

ggcaggatgg agcatccggg agactgcctg tcttgcaaaa tcatatgcgc agatgtggca     9960

gctcctttat ttccacagaa gagaccttcg actgatggct aatgccattt gctcggctgt    10020

gccagttgac tgggtaccaa ctgggagaac cacctggtca atccatggaa agggagaatg    10080

gatgaccact gaggacatgc tcatggtgtg gaatagagtg tggattgagg agaacgacca    10140

tatggaggac aagactcctg taacaaaatg gacagacatt ccctatctag gaaaaaggga    10200

ggacttatgg tgtggatccc ttatagggca cagaccccgc accacttggg ctgaaaacat    10260

caaagacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

tctatccacc caagtccgct acttgggtga ggaagggtcc acacccggag tgttgtaagc    10380

accaatttta gtgttgtcag gcctgctagt cagccacagt ttggggaaag ctgtgcagcc    10440

tgtaaccccc ccaggagaag ctgggaaacc aagctcatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggaa gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagactagct gtgaatctcc agcagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacagcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


<210>  7
<211>  10794
<212>  DNA
<213>  Zika virus, NCBI Reference Sequence: NC_012532.1

<400>  7
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaaccccaa      120

agaagaaatc cggaggatcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa      180

ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag      240

aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct      300

tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa      360

gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg      420

cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat      480

cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat      540

ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca      600

catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga      660

tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca      720

caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag      780

gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat      840

caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc      900

ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat     1020

gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc     1080

acaggacaag ccaacagtcg acatagagtt ggtcacgacg acggttagta acatggccga     1140

ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac     1320

atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct     1380

ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttggatatga     1440

aactgacgaa gatagagcga aagtcgaggt tacgcctaat tcaccaagag cggaagcaac     1500

cttgggaggc tttggaagct taggacttga ctgtgaacca aggacaggcc ttgacttttc     1560

agatctgtat tacctgacca tgaacaataa gcattggttg gtgcacaaag agtggtttca     1620

tgacatccca ttgccttggc atgctggggc agacaccgga actccacact ggaacaacaa     1680

agaggcattg gtagaattca aggatgccca cgccaagagg caaaccgtcg tcgttctggg     1740

gagccaggaa ggagccgttc acacggctct cgctggagct ctagaggctg agatggatgg     1800

tgcaaaggga aggctgttct ctggccattt gaaatgccgc ctaaaaatgg acaagcttag     1860

attgaagggc gtgtcatatt ccttgtgcac tgcggcattc acattcacca aggtcccagc     1920

tgaaacactg catggaacag tcacagtgga ggtgcagtat gcagggacag atggaccctg     1980

caagatccca gtccagatgg cggtggacat gcagaccctg accccagttg gaaggctgat     2040

aaccgccaac cccgtgatta ctgaaagcac tgagaactca aagatgatgt tggagcttga     2100

cccaccattt ggggattctt acattgtcat aggagttggg gacaagaaaa tcacccacca     2160

ctggcatagg agtggtagca ccatcggaaa ggcatttgag gccactgtga gaggcgccaa     2220

gagaatggca gtcctggggg atacagcctg ggacttcgga tcagtcgggg gtgtgttcaa     2280

ctcactgggt aagggcattc accagatttt tggagcagcc ttcaaatcac tgtttggagg     2340

aatgtcctgg ttctcacaga tcctcatagg cacgctgcta gtgtggttag gtttgaacac     2400

aaagaatgga tctatctccc tcacatgctt ggccctgggg ggagtgatga tcttcctctc     2460

cacggctgtt tctgctgacg tggggtgctc agtggacttc tcaaaaaagg aaacgagatg     2520

tggcacgggg gtattcatct ataatgatgt tgaagcctgg agggaccggt acaagtacca     2580

tcctgactcc ccccgcagat tggcagcagc agtcaagcag gcctgggaag aggggatctg     2640

tgggatctca tccgtttcaa gaatggaaaa catcatgtgg aaatcagtag aaggggagct     2700

caatgctatc ctagaggaga atggagttca actgacagtt gttgtgggat ctgtaaaaaa     2760

ccccatgtgg agaggtccac aaagattgcc agtgcctgtg aatgagctgc cccatggctg     2820

gaaagcctgg gggaaatcgt attttgttag ggcggcaaag accaacaaca gttttgttgt     2880

cgacggtgac acactgaagg aatgtccgct tgagcacaga gcatggaata gttttcttgt     2940

ggaggatcac gggtttggag tcttccacac cagtgtctgg cttaaggtca gagaagatta     3000

ctcattagaa tgtgacccag ccgtcatagg aacagctgtt aagggaaggg aggccgcgca     3060

cagtgatctg ggctattgga ttgaaagtga aaagaatgac acatggaggc tgaagagggc     3120

ccacctgatt gagatgaaaa catgtgaatg gccaaagtct cacacattgt ggacagatgg     3180

agtagaagaa agtgatctta tcatacccaa gtctttagct ggtccactca gccaccacaa     3240

caccagagag ggttacagaa cccaagtgaa agggccatgg cacagtgaag agcttgaaat     3300

ccggtttgag gaatgtccag gcaccaaggt ttacgtggag gagacatgcg gaactagagg     3360

accatctctg agatcaacta ctgcaagtgg aagggtcatt gaggaatggt gctgtaggga     3420

atgcacaatg cccccactat cgtttcgagc aaaagacggc tgctggtatg gaatggagat     3480

aaggcccagg aaagaaccag agagcaactt agtgaggtca atggtgacag cggggtcaac     3540

cgatcatatg gaccacttct ctcttggagt gcttgtgatt ctactcatgg tgcaggaggg     3600

gttgaagaag agaatgacca caaagatcat catgagcaca tcaatggcag tgctggtagt     3660

catgatcttg ggaggatttt caatgagtga cctggccaag cttgtgatcc tgatgggtgc     3720

tactttcgca gaaatgaaca ctggaggaga tgtagctcac ttggcattgg tagcggcatt     3780

taaagtcaga ccagccttgc tggtctcctt cattttcaga gccaattgga caccccgtga     3840

gagcatgctg ctagccctgg cttcgtgtct tctgcaaact gcgatctctg ctcttgaagg     3900

tgacttgatg gtcctcatta atggatttgc tttggcctgg ttggcaattc gagcaatggc     3960

cgtgccacgc actgacaaca tcgctctacc aatcttggct gctctaacac cactagctcg     4020

aggcacactg ctcgtggcat ggagagcggg cctggctact tgtggaggga tcatgctcct     4080

ctccctgaaa gggaaaggta gtgtgaagaa gaacctgcca tttgtcatgg ccctgggatt     4140

gacagctgtg agggtagtag accctattaa tgtggtagga ctactgttac tcacaaggag     4200

tgggaagcgg agctggcccc ctagtgaagt tctcacagcc gttggcctga tatgtgcact     4260

ggccggaggg tttgccaagg cagacattga gatggctgga cccatggctg cagtaggctt     4320

gctaattgtc agctatgtgg tctcgggaaa gagtgtggac atgtacattg aaagagcagg     4380

tgacatcaca tgggaaaagg acgcggaagt cactggaaac agtcctcggc ttgacgtggc     4440

actggatgag agtggtgact tctccttggt agaggaagat ggtccaccca tgagagagat     4500

catactcaag gtggtcctga tggccatctg tggcatgaac ccaatagcta taccttttgc     4560

tgcaggagcg tggtatgtgt atgtgaagac tgggaaaagg agtggcgccc tctgggacgt     4620

gcctgctccc aaagaagtga agaaaggaga gaccacagat ggagtgtaca gagtgatgac     4680

tcgcagactg ctaggttcaa cacaggttgg agtgggagtc atgcaagagg gagtcttcca     4740

caccatgtgg cacgttacaa aaggagccgc actgaggagc ggtgagggaa gacttgatcc     4800

atactggggg gatgtcaagc aggacttggt gtcatactgt gggccttgga agttggatgc     4860

agcttgggat ggactcagcg aggtacagct tttggccgta cctcccggag agagggccag     4920

aaacattcag accctgcctg gaatattcaa gacaaaggac ggggacatcg gagcagttgc     4980

tctggactac cctgcaggga cctcaggatc tccgatccta gacaaatgtg gaagagtgat     5040

aggactctat ggcaatgggg ttgtgatcaa gaatggaagc tatgttagtg ctataaccca     5100

gggaaagagg gaggaggaga ctccggttga atgtttcgaa ccctcgatgc tgaagaagaa     5160

gcagctaact gtcttggatc tgcatccagg agccggaaaa accaggagag ttcttcctga     5220

aatagtccgt gaagccataa aaaagagact ccggacagtg atcttggcac caactagggt     5280

tgtcgctgct gagatggagg aggccttgag aggacttccg gtgcgttaca tgacaacagc     5340

agtcaacgtc acccattctg ggacagaaat cgttgatttg atgtgccatg ccactttcac     5400

ttcacgctta ctacaaccca tcagagtccc taattacaat ctcaacatca tggatgaagc     5460

ccacttcaca gacccctcaa gtatagctgc aagaggatac atatcaacaa gggttgaaat     5520

gggcgaggcg gctgccattt ttatgactgc cacaccacca ggaacccgtg atgcgtttcc     5580

tgactctaac tcaccaatca tggacacaga agtggaagtc ccagagagag cctggagctc     5640

aggctttgat tgggtgacag accattctgg gaaaacagtt tggttcgttc caagcgtgag     5700

aaacggaaat gaaatcgcag cctgtctgac aaaggctgga aagcgggtca tacagctcag     5760

caggaagact tttgagacag aatttcagaa aacaaaaaat caagagtggg actttgtcat     5820

aacaactgac atctcagaga tgggcgccaa cttcaaggct gaccgggtca tagactctag     5880

gagatgccta aaaccagtca tacttgatgg tgagagagtc atcttggctg ggcccatgcc     5940

tgtcacgcat gctagtgctg ctcagaggag aggacgtata ggcaggaacc ctaacaaacc     6000

tggagatgag tacatgtatg gaggtgggtg tgcagagact gatgaaggcc atgcacactg     6060

gcttgaagca agaatgcttc ttgacaacat ctacctccag gatggcctca tagcctcgct     6120

ctatcggcct gaggccgata aggtagccgc cattgaggga gagtttaagc tgaggacaga     6180

gcaaaggaag accttcgtgg aactcatgaa gagaggagac cttcccgtct ggctagccta     6240

tcaggttgca tctgccggaa taacttacac agacagaaga tggtgctttg atggcacaac     6300

caacaacacc ataatggaag acagtgtacc agcagaggtt tggacaaagt atggagagaa     6360

gagagtgctc aaaccgagat ggatggatgc tagggtctgt tcagaccatg cggccctgaa     6420

gtcgttcaaa gaattcgccg ctggaaaaag aggagcggct ttgggagtaa tggaggccct     6480

gggaacactg ccaggacaca tgacagagag gtttcaggaa gccattgaca acctcgccgt     6540

gctcatgcga gcagagactg gaagcaggcc ttataaggca gcggcagccc aactgccgga     6600

gaccctagag accattatgc tcttaggttt gctgggaaca gtttcactgg ggatcttctt     6660

cgtcttgatg cggaataagg gcatcgggaa gatgggcttt ggaatggtaa cccttggggc     6720

cagtgcatgg ctcatgtggc tttcggaaat tgaaccagcc agaattgcat gtgtcctcat     6780

tgttgtgttt ttattactgg tggtgctcat acccgagcca gagaagcaaa gatctcccca     6840

agataaccag atggcaatta tcatcatggt ggcagtgggc cttctaggtt tgataactgc     6900

aaacgaactt ggatggctgg aaagaacaaa aaatgacata gctcatctaa tgggaaggag     6960

agaagaagga gcaaccatgg gattctcaat ggacattgat ctgcggccag cctccgcctg     7020

ggctatctat gccgcattga caactctcat caccccagct gtccaacatg cggtaaccac     7080

ttcatacaac aactactcct taatggcgat ggccacacaa gctggagtgc tgtttggcat     7140

gggcaaaggg atgccattta tgcatgggga ccttggagtc ccgctgctaa tgatgggttg     7200

ctattcacaa ttaacacccc tgactctgat agtagctatc attctgcttg tggcgcacta     7260

catgtacttg atcccaggcc tacaagcggc agcagcgcgt gctgcccaga aaaggacagc     7320

agctggcatc atgaagaatc ccgttgtgga tggaatagtg gtaactgaca ttgacacaat     7380

gacaatagac ccccaggtgg agaagaagat gggacaagtg ttactcatag cagtagccat     7440

ctccagtgct gtgctgctgc ggaccgcctg gggatggggg gaggctggag ctctgatcac     7500

agcagcgacc tccaccttgt gggaaggctc tccaaacaaa tactggaact cctctacagc     7560

cacctcactg tgcaacatct tcagaggaag ctatctggca ggagcttccc ttatctatac     7620

agtgacgaga aacgctggcc tggttaagag acgtggaggt gggacgggag agactctggg     7680

agagaagtgg aaagctcgtc tgaatcagat gtcggccctg gagttctact cttataaaaa     7740

gtcaggtatc actgaagtgt gtagagagga ggctcgccgt gccctcaagg atggagtggc     7800

cacaggagga catgccgtat cccggggaag tgcaaagatc agatggttgg aggagagagg     7860

atatctgcag ccctatggga aggttgttga cctcggatgt ggcagagggg gctggagcta     7920

ttatgccgcc accatccgca aagtgcagga ggtgagagga tacacaaagg gaggtcccgg     7980

tcatgaagaa cccatgctgg tgcaaagcta tgggtggaac atagttcgtc tcaagagtgg     8040

agtggacgtc ttccacatgg cggctgagcc gtgtgacact ctgctgtgtg acataggtga     8100

gtcatcatct agtcctgaag tggaagagac acgaacactc agagtgctct ctatggtggg     8160

ggactggctt gaaaaaagac caggggcctt ctgtataaag gtgctgtgcc catacaccag     8220

cactatgatg gaaaccatgg agcgactgca acgtaggcat gggggaggat tagtcagagt     8280

gccattgtgt cgcaactcca cacatgagat gtactgggtc tctggggcaa agagcaacat     8340

cataaaaagt gtgtccacca caagtcagct cctcctggga cgcatggatg gccccaggag     8400

gccagtgaaa tatgaggagg atgtgaacct cggctcgggt acacgagctg tggcaagctg     8460

tgctgaggct cctaacatga aaatcatcgg caggcgcatt gagagaatcc gcaatgaaca     8520

tgcagaaaca tggtttcttg atgaaaacca cccatacagg acatgggcct accatgggag     8580

ctacgaagcc cccacgcaag gatcagcgtc ttccctcgtg aacggggttg ttagactcct     8640

gtcaaagcct tgggacgtgg tgactggagt tacaggaata gccatgactg acaccacacc     8700

atacggccaa caaagagtct tcaaagaaaa agtggacacc agggtgccag atccccaaga     8760

aggcactcgc caggtaatga acatagtctc ttcctggctg tggaaggagc tggggaaacg     8820

caagcggcca cgcgtctgca ccaaagaaga gtttatcaac aaggtgcgca gcaatgcagc     8880

actgggagca atatttgaag aggaaaaaga atggaagacg gctgtggaag ctgtgaatga     8940

tccaaggttt tgggccctag tggataggga gagagaacac cacctgagag gagagtgtca     9000

cagctgtgtg tacaacatga tgggaaaaag agaaaagaag caaggagagt tcgggaaagc     9060

aaaaggtagc cgcgccatct ggtacatgtg gttgggagcc agattcttgg agtttgaagc     9120

ccttggattc ttgaacgagg accattggat gggaagagaa aactcaggag gtggagtcga     9180

agggttagga ttgcaaagac ttggatacat tctagaagaa atgaatcggg caccaggagg     9240

aaagatgtac gcagatgaca ctgctggctg ggacacccgc attagtaagt ttgatctgga     9300

gaatgaagct ctgattacca accaaatgga ggaagggcac agaactctgg cgttggccgt     9360

gattaaatac acataccaaa acaaagtggt gaaggttctc agaccagctg aaggaggaaa     9420

aacagttatg gacatcattt caagacaaga ccagagaggg agtggacaag ttgtcactta     9480

tgctctcaac acattcacca acttggtggt gcagcttatc cggaacatgg aagctgagga     9540

agtgttagag atgcaagact tatggttgtt gaggaagcca gagaaagtga ccagatggtt     9600

gcagagcaat ggatgggata gactcaaacg aatggcggtc agtggagatg actgcgttgt     9660

gaagccaatc gatgataggt ttgcacatgc cctcaggttc ttgaatgaca tgggaaaagt     9720

taggaaagac acacaggagt ggaaaccctc gactggatgg agcaattggg aagaagtccc     9780

gttctgctcc caccacttca acaagctgta cctcaaggat gggagatcca ttgtggtccc     9840

ttgccgccac caagatgaac tgattggccg agctcgcgtc tcaccagggg caggatggag     9900

catccgggag actgcctgtc ttgcaaaatc atatgcgcag atgtggcagc tcctttattt     9960

ccacagaaga gaccttcgac tgatggctaa tgccatttgc tcggctgtgc cagttgactg    10020

ggtaccaact gggagaacca cctggtcaat ccatggaaag ggagaatgga tgaccactga    10080

ggacatgctc atggtgtgga atagagtgtg gattgaggag aacgaccata tggaggacaa    10140

gactcctgta acaaaatgga cagacattcc ctatctagga aaaagggagg acttatggtg    10200

tggatccctt atagggcaca gaccccgcac cacttgggct gaaaacatca aagacacagt    10260

caacatggtg cgcaggatca taggtgatga agaaaagtac atggactatc tatccaccca    10320

agtccgctac ttgggtgagg aagggtccac acccggagtg ttgtaagcac caattttagt    10380

gttgtcaggc ctgctagtca gccacagttt ggggaaagct gtgcagcctg taaccccccc    10440

aggagaagct gggaaaccaa gctcatagtc aggccgagaa cgccatggca cggaagaagc    10500

catgctgcct gtgagcccct cagaggacac tgagtcaaaa aaccccacgc gcttggaagc    10560

gcaggatggg aaaagaaggt ggcgaccttc cccacccttc aatctggggc ctgaactgga    10620

gactagctgt gaatctccag cagagggact agtggttaga ggagaccccc cggaaaacgc    10680

aaaacagcat attgacgtgg gaaagaccag agactccatg agtttccacc acgctggccg    10740

ccaggcacag atcgccgaac ttcggcggcc ggtgtgggga aatccatggt ttct          10794


<210>  8
<211>  10676
<212>  DNA
<213>  Zika virus strain ZikaSPH2015

<400>  8
gttgttactg ttgctgactc agactgcgac agttcgagtt tgaagcgaaa gctagcaaca       60

gtatcaacag gttttatttg gatttggaaa cgagagtttc tggtcatgaa aaacccaaaa      120

aagaaatccg gaggattccg gattgtcaat atgctaaaac gcggagtagc ccgtgtgagc      180

ccctttgggg gcttgaagag gctgccagcc ggacttctgc tgggtcatgg gcccatcagg      240

atggtcttgg caattctagc ctttttgaga ttcacggcaa tcaagccatc actgggtctc      300

atcaatagat ggggttcagt ggggaaaaaa gaggctatgg aaataataaa gaagttcaag      360

aaagatctgg ctgccatgct gagaataatc aatgctagga aggagaagaa gagacggggc      420

gcagatacta gtgtcggaat tgttggcctc ctgctgacca cagctatggc agcggaggtc      480

actagacgtg ggagtgcata ctatatgtac ttggacagaa acgatgctgg ggaggccata      540

tcttttccaa ccacattggg gatgaataag tgttatatac agatcatgga tcttggacac      600

atgtgtgatg ccaccatgag ctatgaatgc cctatgctgg atgagggggt ggaaccagat      660

gacgtcgatt gttggtgcaa cacgacgtca acttgggttg tgtacggaac ctgccatcac      720

aaaaaaggtg aagcacggag atctagaaga gctgtgacgc tcccctccca ttccactagg      780

aagctgcaaa cgcggtcgca aacctggttg gaatcaagag aatacacaaa gcacttgatt      840

agagtcgaaa attggatatt caggaaccct ggcttcgcgt tagcagcagc tgccatcgct      900

tggcttttgg gaagctcaac gagccaaaaa gtcatatact tggtcatgat actgctgatt      960

gccccggcat acagcatcag gtgcatagga gtcagcaata gggactttgt ggaaggtatg     1020

tcaggtggga cttgggttga tattgtcttg gaacatggag gttgtgtcac cgtaatggca     1080

caggacaaac cgactgtcga catagagctg gttacaacaa cagtcagcaa catggcggag     1140

gtaagatcct actgctatga ggcatcaata tcagacatgg cttcggacag ccgctgccca     1200

acacaaggtg aagcctacct tgacaagcaa tcagacactc aatatgtctg caaaagaacg     1260

ttagtggaca gaggctgggg aaatggatgt ggactttttg gcaaagggag tctggtgaca     1320

tgcgctaagt ttgcatgctc caagaaaatg accgggaaga gcatccagcc agagaatctg     1380

gagtaccgga taatgctgtc agttcatggc tcccagcaca gtgggatgat cgttaatgac     1440

acaggacatg aaactgatga gaatagagcg aaggttgaga taacgcccaa ttcaccaaga     1500

gccgaagcca ccctgggggg ttttggaagc ctaggacttg attgtgaacc gaggacaggc     1560

cttgactttt cagatttgta ttacttgact atgaataaca agcactggtt ggttcacaag     1620

gagtggttcc acgacattcc attaccttgg cacgctgggg cagacaccgg aactccacac     1680

tggaacaaca aagaagcact ggtagagttc aaggacgcac atgccaaaag gcaaactgtc     1740

gtggttctag ggagtcaaga aggagcagtt cacacggccc ttgctggagc tctggaggct     1800

gagatggatg gtgcaaaggg aaggctgtcc tctggccact tgaaatgtcg cctgaaaatg     1860

gataaactta gattgaaggg cgtgtcatac tccttgtgta ccgcagcgtt cacattcacc     1920

aagatcccgg ctgaaacact gcacgggaca gtcacagtgg aggtacagta cgcagggaca     1980

gatggacctt gcaaggttcc agctcagatg gcggtggaca tgcaaactct gaccccagtt     2040

gggaggttga taaccgctaa ccccgtaatc actgaaagca ctgagaactc taagatgatg     2100

ctggaacttg atccaccatt tggggactct tacattgtca taggagtcgg ggagaagaag     2160

atcacccacc actggcacag gagtggcagc accattggaa aagcatttga agccactgtg     2220

agaggtgcca agagaatggc agtcttggga gacacagcct gggactttgg atcagttgga     2280

ggcgctctca actcattggg caagggcatc catcaaattt ttggagcagc tttcaaatca     2340

ttgtttggag gaatgtcctg gttctcacaa attctcattg gaacgttgct gatgtggttg     2400

ggtctgaaca caaagaatgg atctatttcc cttatgtgct tggccttagg gggagtgttg     2460

atcttcttat ccacagccgt ctctgctgat gtggggtgct cggtggactt ctcaaagaag     2520

gagacgagat gcggtacagg ggtgttcgtc tataacgacg ttgaagcctg gagggacagg     2580

tacaagtacc atcctgactc cccccgtaga ttggcagcag cagtcaagca agcctgggaa     2640

gatggtatct gcgggatctc ctctgtttca agaatggaaa acatcatgtg gagatcagta     2700

gaaggggagc tcaacgcaat cctggaagag aatggagttc aactgacggt cgttgtggga     2760

tctgtaaaaa accccatgtg gagaggtcca cagagattgc ccgtgcctgt gaacgagctg     2820

ccccacggct ggaaggcttg ggggaaatcg cacttcgtca gagcagcaaa gacaaataac     2880

agctttgtcg tggatggtga cacactgaag gaatgcccac tcaaacatag agcatggaac     2940

agctttcttg tggaggatca tgggttcggg gtatttcaca ctagtgtctg gctcaaggtt     3000

agagaagatt attcattaga gtgtgatcca gccgttattg gaacagctgt taagggaaag     3060

gaggctgtac acagtgatct aggctactgg attgagagtg agaagaatga cacatggagg     3120

ctgaagaggg cccatctgat cgagatgaaa acatgtgaat ggccaaagtc ccacacattg     3180

tggacagatg gaatagaaga gagtgatctg atcataccca agtctttagc tgggccactc     3240

agccatcaca ataccagaga gggctacagg acccaaatga aagggccatg gcacagtgaa     3300

gagcttgaaa ttcggtttga ggaatgccca ggcactaagg tccacgtgga ggaaacatgt     3360

ggaacaagag gaccatctct gagatcaacc actgcaagcg gaagggtgat cgaggaatgg     3420

tgctgcaggg agtgcacaat gcccccactg tcgttccggg ctaaagatgg ctgttggtat     3480

ggaatggaga taaggcccag gaaagaacca gaaagcaact tagtaaggtc aatggtgact     3540

gcaggatcaa ctgatcacat ggatcacttc tcccttggag tgcttgtgat tctgctcatg     3600

gtgcaggaag ggctgaagaa gagaatgacc acaaagatca tcataagcac atcaatggca     3660

gtgctggtag ctatgatcct gggaggattt tcaatgagtg acctggctaa gcttgcaatt     3720

ttgatgggtg ccaccttcgc ggaaatgaac actggaggag atgtagctca tctggcgctg     3780

atagcggcat tcaaagtcag accagcgttg ctggtatctt tcatcttcag agctaattgg     3840

acaccccgtg aaagcatgct gctggccttg gcctcgtgtc ttttgcaaac tgcgatctcc     3900

gccttggaag gcgacctgat ggttctcatc aatggttttg ctttggcctg gttggcaata     3960

cgagcgatgg ttgttccacg cactgataac atcaccttgg caatcctggc tgctctgaca     4020

ccactggccc ggggcacact gcttgtggcg tggagagcag gccttgctac ttgcgggggg     4080

tttatgctcc tctctctgaa gggaaaaggc agtgtgaaga agaacttacc atttgtcatg     4140

gccctgggac taaccgctgt gaggctggtc gaccccatca acgtggtggg gctgctgttg     4200

ctcacaagga gtgggaagcg gagctggccc cctagcgaag tactcacagc tgttggcctg     4260

atatgcgcat tggctggagg gttcgccaag gcagatatag agatggctgg gcccatggcc     4320

gcggtcggtc tgctaattgt cagttacgtg gtctcaggaa agagtgtgga catgtacatt     4380

gaaagagcag gtgacatcac atgggaaaaa gatgcggaag tcactggaaa cagtccccgg     4440

ctcgatgtgg cgctagatga gagtggtgat ttctccctgg tggaggatga cggtcccccc     4500

atgagagaga tcatactcaa ggtggtcctg atgaccatct gtggcatgaa cccaatagcc     4560

ataccctttg cagctggagc gtggtacgta tacgtgaaga ctggaaaaag gagtggtgct     4620

ctatgggatg tgcctgctcc caaggaagta aaaaaggggg agaccacaga tggagtgtac     4680

agagtaatga ctcgtagact gctaggttca acacaagttg gagtgggagt tatgcaagag     4740

ggggtctttc acactatgtg gcacgtcaca aaaggatccg cgctgagaag cggtgaaggg     4800

agacttgatc catactgggg agatgtcaag caggatctgg tgtcatactg tggtccatgg     4860

aagctagatg ccgcctggga cgggcacagc gaggtgcagc tcttggccgt gccccccgga     4920

gagagagcga ggaacatcca gactctgccc ggaatattta agacaaagga tggggacatt     4980

ggagcggttg cgctggatta cccagcagga acttcaggat ctccaatcct agacaagtgt     5040

gggagagtga taggacttta tggcaatggg gtcgtgatca aaaatgggag ttatgttagt     5100

gccatcaccc aagggaggag ggaggaagag actcctgttg agtgcttcga gccttcgatg     5160

ctgaagaaga agcagctaac tgtcttagac ttgcatcctg gagctgggaa aaccaggaga     5220

gttcttcctg aaatagtccg tgaagccata aaaacaagac tccgtactgt gatcttagct     5280

ccaaccaggg ttgtcgctgc tgaaatggag gaagccctta gagggcttcc agtgcgttat     5340

atgacaacag cagtcaatgt cacccactct ggaacagaaa tcgtcgactt aatgtgccat     5400

gccaccttca cttcacgtct actacagcca atcagagtcc ccaactataa tctgtatatt     5460

atggatgagg cccacttcac agatccctca agtatagcag caagaggata catttcaaca     5520

agggttgaga tgggcgaggc ggctgccatc ttcatgaccg ccacgccacc aggaacccgt     5580

gacgcatttc cggactccaa ctcaccaatt atggacaccg aagtggaagt cccagagaga     5640

gcctggagct caggctttga ttgggtgacg gattattctg gaaaaacagt ttggtttgtt     5700

ccaagcgtga ggaacggcaa tgagatcgca gcttgtctga caaaggctgg aaaacgggtc     5760

atacagctca gcagaaagac ttttgagaca gagttccaga aaacaaaaca tcaagagtgg     5820

gactttgtcg tgacaactga catttcagag atgggcgcca actttaaagc tgaccgtgtc     5880

atagattcca ggagatgcct aaagccggtc atacttgatg gcgagagagt cattctggct     5940

ggacccatgc ctgtcacaca tgccagcgct gcccagagga gggggcgcat aggcaggaat     6000

cccaacaaac ctggagatga gtatctgtat ggaggtgggt gcgcagagac tgacgaagac     6060

catgcacact ggcttgaagc aagaatgctc cttgacaata tttacctcca agatggcctc     6120

atagcctcgc tctatcgacc tgaggccgac aaagtagcag ccattgaggg agagttcaag     6180

cttaggacgg agcaaaggaa gacctttgtg gaactcatga aaagaggaga tcttcctgtt     6240

tggctggcct atcaggttgc atctgccgga ataacctaca cagatagaag atggtgcttt     6300

gatggcacga ccaacaacac cataatggaa gacagtgtgc cggcagaggt gtggaccaga     6360

cacggagaga aaagagtgct caaaccgagg tggatggacg ccagagtttg ttcagatcat     6420

gcggccctga agtcattcaa ggagtttgcc gctgggaaaa gaggagcggc ttttggagtg     6480

atggaagccc tgggaacact gccaggacac atgacagaga gattccagga agccattgac     6540

aacctcgctg tgctcatgcg ggcagagact ggaagcaggc cttacaaagc cgcggcggcc     6600

caattgccgg agaccctaga gaccattatg cttttggggt tgctgggaac agtctcgctg     6660

ggaatctttt tcgtcttgat gaggaacaag ggcataggga agatgggctt tggaatggtg     6720

actcttgggg ccagcgcatg gctcatgtgg ctctcggaaa ttgagccagc cagaattgca     6780

tgtgtcctca ttgttgtgtt cctattgctg gtggtgctca tacctgagcc agaaaagcaa     6840

agatctcccc aggacaacca aatggcaatc atcatcatgg tagcagtagg tcttctgggc     6900

ttgattaccg ccaatgaact cggatggttg gagagaacaa agagtgacct aagccatcta     6960

atgggaagga gagaggaggg ggcaaccatg ggattctcaa tggacattga cctgcggcca     7020

gcctcagctt gggccatcta tgctgccttg acaactttca ttaccccagc cgtccaacat     7080

gcagtgacca cttcatacaa caactactcc ttaatggcga tggccacgca agctggagtg     7140

ttgtttggta tgggcaaagg gatgccattc tacgcatggg actttggagt cccgctgcta     7200

atgataggtt gctactcaca attaacgccc ctgaccctaa tagtggccat cattttgctc     7260

gtggcgcact acatgtactt gatcccaggg ctgcaggcag cagctgcgcg tgctgcccag     7320

aagagaacgg cagctggcat catgaagaac cctgttgtgg atggaatagt ggtgactgac     7380

attgacacaa tgacaattga cccccaagtg gagaaaaaga tgggacaggt gctactcatg     7440

gcagtagccg tctccagcgc catactgtcg cggaccgcct gggggtgggg ggaggctggg     7500

gccctgatca cagccgcaac ttccactttg tgggaaggct ctccgaacaa gtactggaac     7560

tcctctacag ccacttcact gtgtaacatt tttaggggaa gttacttggc tggagcttct     7620

ctaatctaca cagtaacaag aaacgctggc ttggtcaaga gacgtggggg tggaacagga     7680

gagaccctgg gagagaaatg gaaggcccgc ttgaaccaga tgtcggccct ggagttctac     7740

tcctacaaaa agtcaggcat caccgaggtg tgcagagaag aggcccgccg cgccctcaag     7800

gacggtgtgg caacgggagg ccatgctgtg tcccgaggaa gtgcaaagct gagatggttg     7860

gtggagcggg gatacctgca gccctatgga aaggtcattg atcttggatg tggcagaggg     7920

ggctggagtt actacgccgc caccatccgc aaagttcaag aagtgaaagg atacacaaaa     7980

ggaggccctg gtcatgaaga acccgtgttg gtgcaaagct atgggtggaa catagtccgt     8040

cttaagagtg gggtggacgt ctttcatatg gcggctgagc cgtgtgacac gttgctgtgt     8100

gacataggtg agtcatcatc tagtcctgaa gtggaagaag cacggacgct cagagtcctc     8160

tccatggtgg gggattggct tgaaaaaaga ccaggagcct tttgtataaa agtgttgtgc     8220

ccatacacca gcactatgat ggaaaccctg gagcgactgc agcgtaggta tgggggagga     8280

ctggtcagag tgccactctc ccgcaactct acacatgaga tgtactgggt ctctggagcg     8340

aaaagcaaca ccataaaaag tgtgtccacc acgagccagc tcctcttggg gcgcatggac     8400

gggcctagga ggccagtgaa atatgaggag gatgtgaatc tcggctctgg cacgcgggct     8460

gtggtaagct gcgctgaagc tcccaacatg aagatcattg gtaaccgcat tgaaaggatc     8520

cgcagtgagc acgcggaaac gtggttcttt gacgagaacc acccatatag gacatgggct     8580

taccatggaa gctatgaggc ccccacacaa gggtcagcgt cctctctaat aaacggggtt     8640

gtcaggctcc tgtcaaaacc ctgggatgtg gtgactggag tcacaggaat agccatgacc     8700

gacaccacac cgtatggtca gcaaagagtt ttcaaggaaa aagtggacac tagggtgcca     8760

gacccccaag aaggtactcg tcaggttatg agcatggtct cttcctggtt gtggaaagag     8820

ctaggcaaac acaaacggcc acgagtctgt accaaagaag agttcatcaa caaggttcgt     8880

agcaatgcag cattaggggc aatatttgaa gaggaaaaag agtggaagac tgcagtggaa     8940

gctgtgaacg atccaaggtt ctgggctcta gtggacaagg aaagagagca ccacctgaga     9000

ggagagtgcc agagttgtgt gtacaacatg atgggaaaaa gagaaaagaa acaaggggaa     9060

tttggaaagg ccaagggcag ccgcgccatc tggtatatgt ggctaggggc tagatttcta     9120

gagttcgaag cccttggatt cttgaacgag gatcactgga tggggagaga gaactcagga     9180

ggtggtgttg aagggctggg attacaaaga ctcggatatg tcctagaaga gatgagtcgc     9240

ataccaggag gaaggatgta tgcagatgac actgctggct gggacacccg catcagcagg     9300

tttgatctgg agaatgaagc tctaatcacc aaccaaatgg agaaagggca cagggccttg     9360

gcattggcca taatcaagta cacataccaa aacaaagtgg taaaggtcct tagaccagct     9420

gaaaaaggga aaacagttat ggacattatt tcgagacaag accaaagggg gagcggacaa     9480

gttgtcactt acgctcttaa cacatttacc aacctagtgg tgcaactcat tcggaatatg     9540

gaggctgagg aagtcctaga gatgcaagac ttgtggctgc tgcggaggtc agagaaagtg     9600

accaactggt tgcagagcaa cggatgggat aggctcaaac gaatggcagt cagtggagat     9660

gattgcgttg tgaagccaat tgatgatagg tttgcacatg ccctcaggtt cttgaatgat     9720

atgggaaaag ttaggaagga cacacaagag tggaaaccct caactggatg ggacaactgg     9780

gaagaagttc cgttttgctc ccaccacttc aacaagctcc atctcaagga cgggaggtcc     9840

attgtggttc cctgccgcca ccaagatgaa ctgattggcc gggcccgcgt ctctccaggg     9900

gcgggatgga gcatccggga gactgcttgc ctagcaaaat catatgcgca aatgtggcag     9960

ctcctttatt tccacagaag ggacctccga ctgatggcca atgccatttg ttcatctgtg    10020

ccagttgact gggttccaac tgggagaact acctggtcaa tccatggaaa gggagaatgg    10080

atgaccactg aagacatgct tgtggtgtgg aacagagtgt ggattgagga gaacgaccac    10140

atggaagaca agaccccagt tacgaaatgg acagacattc cctatttggg aaaaagggaa    10200

gacttgtggt gtggatctct catagggcac agaccgcgca ccacctgggc tgagaacatt    10260

aaaaacacag tcaacatggt gcgcaggatc ataggtgatg aagaaaagta catggactac    10320

ctatccaccc aagttcgcta cttgggtgaa gaagggtcta cacctggagt gctgtaagca    10380

ccaatcttaa tgttgtcagg cctgctagtc agccacagct tggggaaagc tgtgcagcct    10440

gtgacccccc caggagaagc tgggaaacca agcctatagt caggccgaga acgccatggc    10500

acggaagaag ccatgctgcc tgtgagcccc tcagaggaca ctgagtcaaa aaaccccacg    10560

cgcttggagg cgcaggatgg gaaaagaagg tggcgacctt ccccaccctt caatctgggg    10620

cctgaactgg agatcagctg tggatctcca gaagagggac tagtggttag aggaga        10676


<210>  9
<211>  10794
<212>  DNA
<213>  Zika virus strain MR 766

<400>  9
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaaccccaa      120

agaagaaatc cggaggatcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa      180

ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag      240

aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct      300

tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa      360

gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg      420

cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat      480

cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat      540

ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca      600

catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga      660

tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca      720

caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag      780

gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat      840

caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc      900

ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat     1020

gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc     1080

acaggacaag ccaacagtcg acatagagtt ggtcacgacg acggttagta acatggccga     1140

ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac     1320

atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct     1380

ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttggatatga     1440

aactgacgaa gatagagcga aagtcgaggt tacgcctaat tcaccaagag cggaagcaac     1500

cttgggaggc tttggaagct taggacttga ctgtgaacca aggacaggcc ttgacttttc     1560

agatctgtat tacctgacca tgaacaataa gcattggttg gtgcacaaag agtggtttca     1620

tgacatccca ttgccttggc atgctggggc agacaccgga actccacact ggaacaacaa     1680

agaggcattg gtagaattca aggatgccca cgccaagagg caaaccgtcg tcgttctggg     1740

gagccaggaa ggagccgttc acacggctct cgctggagct ctagaggctg agatggatgg     1800

tgcaaaggga aggctgttct ctggccattt gaaatgccgc ctaaaaatgg acaagcttag     1860

attgaagggc gtgtcatatt ccttgtgcac tgcggcattc acattcacca aggtcccagc     1920

tgaaacactg catggaacag tcacagtgga ggtgcagtat gcagggacag atggaccctg     1980

caagatccca gtccagatgg cggtggacat gcagaccctg accccagttg gaaggctgat     2040

aaccgccaac cccgtgatta ctgaaagcac tgagaactca aagatgatgt tggagcttga     2100

cccaccattt ggggattctt acattgtcat aggagttggg gacaagaaaa tcacccacca     2160

ctggcatagg agtggtagca ccatcggaaa ggcatttgag gccactgtga gaggcgccaa     2220

gagaatggca gtcctggggg atacagcctg ggacttcgga tcagtcgggg gtgtgttcaa     2280

ctcactgggt aagggcattc accagatttt tggagcagcc ttcaaatcac tgtttggagg     2340

aatgtcctgg ttctcacaga tcctcatagg cacgctgcta gtgtggttag gtttgaacac     2400

aaagaatgga tctatctccc tcacatgctt ggccctgggg ggagtgatga tcttcctctc     2460

cacggctgtt tctgctgacg tggggtgctc agtggacttc tcaaaaaagg aaacgagatg     2520

tggcacgggg gtattcatct ataatgatgt tgaagcctgg agggaccggt acaagtacca     2580

tcctgactcc ccccgcagat tggcagcagc agtcaagcag gcctgggaag aggggatctg     2640

tgggatctca tccgtttcaa gaatggaaaa catcatgtgg aaatcagtag aaggggagct     2700

caatgctatc ctagaggaga atggagttca actgacagtt gttgtgggat ctgtaaaaaa     2760

ccccatgtgg agaggtccac aaagattgcc agtgcctgtg aatgagctgc cccatggctg     2820

gaaagcctgg gggaaatcgt attttgttag ggcggcaaag accaacaaca gttttgttgt     2880

cgacggtgac acactgaagg aatgtccgct tgagcacaga gcatggaata gttttcttgt     2940

ggaggatcac gggtttggag tcttccacac cagtgtctgg cttaaggtca gagaagatta     3000

ctcattagaa tgtgacccag ccgtcatagg aacagctgtt aagggaaggg aggccgcgca     3060

cagtgatctg ggctattgga ttgaaagtga aaagaatgac acatggaggc tgaagagggc     3120

ccacctgatt gagatgaaaa catgtgaatg gccaaagtct cacacattgt ggacagatgg     3180

agtagaagaa agtgatctta tcatacccaa gtctttagct ggtccactca gccaccacaa     3240

caccagagag ggttacagaa cccaagtgaa agggccatgg cacagtgaag agcttgaaat     3300

ccggtttgag gaatgtccag gcaccaaggt ttacgtggag gagacatgcg gaactagagg     3360

accatctctg agatcaacta ctgcaagtgg aagggtcatt gaggaatggt gctgtaggga     3420

atgcacaatg cccccactat cgtttcgagc aaaagacggc tgctggtatg gaatggagat     3480

aaggcccagg aaagaaccag agagcaactt agtgaggtca atggtgacag cggggtcaac     3540

cgatcatatg gaccacttct ctcttggagt gcttgtgatt ctactcatgg tgcaggaggg     3600

gttgaagaag agaatgacca caaagatcat catgagcaca tcaatggcag tgctggtagt     3660

catgatcttg ggaggatttt caatgagtga cctggccaag cttgtgatcc tgatgggtgc     3720

tactttcgca gaaatgaaca ctggaggaga tgtagctcac ttggcattgg tagcggcatt     3780

taaagtcaga ccagccttgc tggtctcctt cattttcaga gccaattgga caccccgtga     3840

gagcatgctg ctagccctgg cttcgtgtct tctgcaaact gcgatctctg ctcttgaagg     3900

tgacttgatg gtcctcatta atggatttgc tttggcctgg ttggcaattc gagcaatggc     3960

cgtgccacgc actgacaaca tcgctctacc aatcttggct gctctaacac cactagctcg     4020

aggcacactg ctcgtggcat ggagagcggg cctggctact tgtggaggga tcatgctcct     4080

ctccctgaaa gggaaaggta gtgtgaagaa gaacctgcca tttgtcatgg ccctgggatt     4140

gacagctgtg agggtagtag accctattaa tgtggtagga ctactgttac tcacaaggag     4200

tgggaagcgg agctggcccc ctagtgaagt tctcacagcc gttggcctga tatgtgcact     4260

ggccggaggg tttgccaagg cagacattga gatggctgga cccatggctg cagtaggctt     4320

gctaattgtc agctatgtgg tctcgggaaa gagtgtggac atgtacattg aaagagcagg     4380

tgacatcaca tgggaaaagg acgcggaagt cactggaaac agtcctcggc ttgacgtggc     4440

actggatgag agtggtgact tctccttggt agaggaagat ggtccaccca tgagagagat     4500

catactcaag gtggtcctga tggccatctg tggcatgaac ccaatagcta taccttttgc     4560

tgcaggagcg tggtatgtgt atgtgaagac tgggaaaagg agtggcgccc tctgggacgt     4620

gcctgctccc aaagaagtga agaaaggaga gaccacagat ggagtgtaca gagtgatgac     4680

tcgcagactg ctaggttcaa cacaggttgg agtgggagtc atgcaagagg gagtcttcca     4740

caccatgtgg cacgttacaa aaggagccgc actgaggagc ggtgagggaa gacttgatcc     4800

atactggggg gatgtcaagc aggacttggt gtcatactgt gggccttgga agttggatgc     4860

agcttgggat ggactcagcg aggtacagct tttggccgta cctcccggag agagggccag     4920

aaacattcag accctgcctg gaatattcaa gacaaaggac ggggacatcg gagcagttgc     4980

tctggactac cctgcaggga cctcaggatc tccgatccta gacaaatgtg gaagagtgat     5040

aggactctat ggcaatgggg ttgtgatcaa gaatggaagc tatgttagtg ctataaccca     5100

gggaaagagg gaggaggaga ctccggttga atgtttcgaa ccctcgatgc tgaagaagaa     5160

gcagctaact gtcttggatc tgcatccagg agccggaaaa accaggagag ttcttcctga     5220

aatagtccgt gaagccataa aaaagagact ccggacagtg atcttggcac caactagggt     5280

tgtcgctgct gagatggagg aggccttgag aggacttccg gtgcgttaca tgacaacagc     5340

agtcaacgtc acccattctg ggacagaaat cgttgatttg atgtgccatg ccactttcac     5400

ttcacgctta ctacaaccca tcagagtccc taattacaat ctcaacatca tggatgaagc     5460

ccacttcaca gacccctcaa gtatagctgc aagaggatac atatcaacaa gggttgaaat     5520

gggcgaggcg gctgccattt ttatgactgc cacaccacca ggaacccgtg atgcgtttcc     5580

tgactctaac tcaccaatca tggacacaga agtggaagtc ccagagagag cctggagctc     5640

aggctttgat tgggtgacag accattctgg gaaaacagtt tggttcgttc caagcgtgag     5700

aaacggaaat gaaatcgcag cctgtctgac aaaggctgga aagcgggtca tacagctcag     5760

caggaagact tttgagacag aatttcagaa aacaaaaaat caagagtggg actttgtcat     5820

aacaactgac atctcagaga tgggcgccaa cttcaaggct gaccgggtca tagactctag     5880

gagatgccta aaaccagtca tacttgatgg tgagagagtc atcttggctg ggcccatgcc     5940

tgtcacgcat gctagtgctg ctcagaggag aggacgtata ggcaggaacc ctaacaaacc     6000

tggagatgag tacatgtatg gaggtgggtg tgcagagact gatgaaggcc atgcacactg     6060

gcttgaagca agaatgcttc ttgacaacat ctacctccag gatggcctca tagcctcgct     6120

ctatcggcct gaggccgata aggtagccgc cattgaggga gagtttaagc tgaggacaga     6180

gcaaaggaag accttcgtgg aactcatgaa gagaggagac cttcccgtct ggctagccta     6240

tcaggttgca tctgccggaa taacttacac agacagaaga tggtgctttg atggcacaac     6300

caacaacacc ataatggaag acagtgtacc agcagaggtt tggacaaagt atggagagaa     6360

gagagtgctc aaaccgagat ggatggatgc tagggtctgt tcagaccatg cggccctgaa     6420

gtcgttcaaa gaattcgccg ctggaaaaag aggagcggct ttgggagtaa tggaggccct     6480

gggaacactg ccaggacaca tgacagagag gtttcaggaa gccattgaca acctcgccgt     6540

gctcatgcga gcagagactg gaagcaggcc ttataaggca gcggcagccc aactgccgga     6600

gaccctagag accattatgc tcttaggttt gctgggaaca gtttcactgg ggatcttctt     6660

cgtcttgatg cggaataagg gcatcgggaa gatgggcttt ggaatggtaa cccttggggc     6720

cagtgcatgg ctcatgtggc tttcggaaat tgaaccagcc agaattgcat gtgtcctcat     6780

tgttgtgttt ttattactgg tggtgctcat acccgagcca gagaagcaaa gatctcccca     6840

agataaccag atggcaatta tcatcatggt ggcagtgggc cttctaggtt tgataactgc     6900

aaacgaactt ggatggctgg aaagaacaaa aaatgacata gctcatctaa tgggaaggag     6960

agaagaagga gcaaccatgg gattctcaat ggacattgat ctgcggccag cctccgcctg     7020

ggctatctat gccgcattga caactctcat caccccagct gtccaacatg cggtaaccac     7080

ttcatacaac aactactcct taatggcgat ggccacacaa gctggagtgc tgtttggcat     7140

gggcaaaggg atgccattta tgcatgggga ccttggagtc ccgctgctaa tgatgggttg     7200

ctattcacaa ttaacacccc tgactctgat agtagctatc attctgcttg tggcgcacta     7260

catgtacttg atcccaggcc tacaagcggc agcagcgcgt gctgcccaga aaaggacagc     7320

agctggcatc atgaagaatc ccgttgtgga tggaatagtg gtaactgaca ttgacacaat     7380

gacaatagac ccccaggtgg agaagaagat gggacaagtg ttactcatag cagtagccat     7440

ctccagtgct gtgctgctgc ggaccgcctg gggatggggg gaggctggag ctctgatcac     7500

agcagcgacc tccaccttgt gggaaggctc tccaaacaaa tactggaact cctctacagc     7560

cacctcactg tgcaacatct tcagaggaag ctatctggca ggagcttccc ttatctatac     7620

agtgacgaga aacgctggcc tggttaagag acgtggaggt gggacgggag agactctggg     7680

agagaagtgg aaagctcgtc tgaatcagat gtcggccctg gagttctact cttataaaaa     7740

gtcaggtatc actgaagtgt gtagagagga ggctcgccgt gccctcaagg atggagtggc     7800

cacaggagga catgccgtat cccggggaag tgcaaagatc agatggttgg aggagagagg     7860

atatctgcag ccctatggga aggttgttga cctcggatgt ggcagagggg gctggagcta     7920

ttatgccgcc accatccgca aagtgcagga ggtgagagga tacacaaagg gaggtcccgg     7980

tcatgaagaa cccatgctgg tgcaaagcta tgggtggaac atagttcgtc tcaagagtgg     8040

agtggacgtc ttccacatgg cggctgagcc gtgtgacact ctgctgtgtg acataggtga     8100

gtcatcatct agtcctgaag tggaagagac acgaacactc agagtgctct ctatggtggg     8160

ggactggctt gaaaaaagac caggggcctt ctgtataaag gtgctgtgcc catacaccag     8220

cactatgatg gaaaccatgg agcgactgca acgtaggcat gggggaggat tagtcagagt     8280

gccattgtgt cgcaactcca cacatgagat gtactgggtc tctggggcaa agagcaacat     8340

cataaaaagt gtgtccacca caagtcagct cctcctggga cgcatggatg gccccaggag     8400

gccagtgaaa tatgaggagg atgtgaacct cggctcgggt acacgagctg tggcaagctg     8460

tgctgaggct cctaacatga aaatcatcgg caggcgcatt gagagaatcc gcaatgaaca     8520

tgcagaaaca tggtttcttg atgaaaacca cccatacagg acatgggcct accatgggag     8580

ctacgaagcc cccacgcaag gatcagcgtc ttccctcgtg aacggggttg ttagactcct     8640

gtcaaagcct tgggacgtgg tgactggagt tacaggaata gccatgactg acaccacacc     8700

atacggccaa caaagagtct tcaaagaaaa agtggacacc agggtgccag atccccaaga     8760

aggcactcgc caggtaatga acatagtctc ttcctggctg tggaaggagc tggggaaacg     8820

caagcggcca cgcgtctgca ccaaagaaga gtttatcaac aaggtgcgca gcaatgcagc     8880

actgggagca atatttgaag aggaaaaaga atggaagacg gctgtggaag ctgtgaatga     8940

tccaaggttt tgggccctag tggataggga gagagaacac cacctgagag gagagtgtca     9000

cagctgtgtg tacaacatga tgggaaaaag agaaaagaag caaggagagt tcgggaaagc     9060

aaaaggtagc cgcgccatct ggtacatgtg gttgggagcc agattcttgg agtttgaagc     9120

ccttggattc ttgaacgagg accattggat gggaagagaa aactcaggag gtggagtcga     9180

agggttagga ttgcaaagac ttggatacat tctagaagaa atgaatcggg caccaggagg     9240

aaagatgtac gcagatgaca ctgctggctg ggacacccgc attagtaagt ttgatctgga     9300

gaatgaagct ctgattacca accaaatgga ggaagggcac agaactctgg cgttggccgt     9360

gattaaatac acataccaaa acaaagtggt gaaggttctc agaccagctg aaggaggaaa     9420

aacagttatg gacatcattt caagacaaga ccagagaggg agtggacaag ttgtcactta     9480

tgctctcaac acattcacca acttggtggt gcagcttatc cggaacatgg aagctgagga     9540

agtgttagag atgcaagact tatggttgtt gaggaagcca gagaaagtga ccagatggtt     9600

gcagagcaat ggatgggata gactcaaacg aatggcggtc agtggagatg actgcgttgt     9660

gaagccaatc gatgataggt ttgcacatgc cctcaggttc ttgaatgaca tgggaaaagt     9720

taggaaagac acacaggagt ggaaaccctc gactggatgg agcaattggg aagaagtccc     9780

gttctgctcc caccacttca acaagctgta cctcaaggat gggagatcca ttgtggtccc     9840

ttgccgccac caagatgaac tgattggccg agctcgcgtc tcaccagggg caggatggag     9900

catccgggag actgcctgtc ttgcaaaatc atatgcgcag atgtggcagc tcctttattt     9960

ccacagaaga gaccttcgac tgatggctaa tgccatttgc tcggctgtgc cagttgactg    10020

ggtaccaact gggagaacca cctggtcaat ccatggaaag ggagaatgga tgaccactga    10080

ggacatgctc atggtgtgga atagagtgtg gattgaggag aacgaccata tggaggacaa    10140

gactcctgta acaaaatgga cagacattcc ctatctagga aaaagggagg acttatggtg    10200

tggatccctt atagggcaca gaccccgcac cacttgggct gaaaacatca aagacacagt    10260

caacatggtg cgcaggatca taggtgatga agaaaagtac atggactatc tatccaccca    10320

agtccgctac ttgggtgagg aagggtccac acccggagtg ttgtaagcac caattttagt    10380

gttgtcaggc ctgctagtca gccacagttt ggggaaagct gtgcagcctg taaccccccc    10440

aggagaagct gggaaaccaa gctcatagtc aggccgagaa cgccatggca cggaagaagc    10500

catgctgcct gtgagcccct cagaggacac tgagtcaaaa aaccccacgc gcttggaagc    10560

gcaggatggg aaaagaaggt ggcgaccttc cccacccttc aatctggggc ctgaactgga    10620

gactagctgt gaatctccag cagagggact agtggttaga ggagaccccc cggaaaacgc    10680

aaaacagcat attgacgtgg gaaagaccag agactccatg agtttccacc acgctggccg    10740

ccaggcacag atcgccgaac ttcggcggcc ggtgtgggga aatccatggt ttct          10794


<210>  10
<211>  10662
<212>  DNA
<213>  Zika virus strain BeH815744 polyprotein gene

<400>  10
gtgaatcaga ctgcgacagt tcgagtttga agcgaaagct agcaacagta tcaacaggtt       60

ttattttgga tttggaaacg agagtttctg gtcatgaaaa acccaaaaaa gaaatccgga      120

ggattccgga ttgtcaatat gctaaaacgc ggagtagccc gtgtgagccc ctttgggggc      180

ttgaagaggc tgccagccgg acttctgctg ggtcatgggc ccatcaggat ggtcttggcg      240

attctagcct ttttgagatt cacggcaatc aagccatcac tgggtctcat caatagatgg      300

ggttcagtgg ggaaaaaaga ggctatggaa ataataaaga agttcaagaa agatctggct      360

gccatgctga gaataatcaa tgctaggaag gagaagaaga gacgaggcgc agatactagt      420

gtcggaattg ttggcctcct gctgaccaca gctatggcag cggaggtcac tagacgtggg      480

agtgcatact atatgtactt ggacagaaac gatgctgggg aggccatatc ttttccaacc      540

acattgggga tgaataagtg ttatatacag atcatggatc ttggacacat gtgtgatgcc      600

accatgagct atgaatgccc tatgctggat gagggggtgg aaccagatga cgtcgattgt      660

tggtgcaaca cgacgtcaac ttgggttgtg tacggaacct gccatcacaa aaaaggtgaa      720

gcacggagat ctagaagagc tgtgacgctc ccctcccatt ccactaggaa gctgcaaacg      780

cggtcgcaaa cctggttgga atcaagagaa tacacaaagc acttgattag agtcgaaaat      840

tggatattta ggaaccctgg cttcgcgtta gcagcagctg ccatcgcttg gcttttggga      900

agctcaacga gccaaaaagt catatacttg gtcatgatac tgctgattgc cccggcatac      960

agcatcaggt gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggacc     1020

tgggttgatg ttgtcttgga acatggaggt tgtgtcaccg taatggcaca ggacaaaccg     1080

actgtcgaca tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac     1140

tgctatgagg catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa     1200

gcctaccttg acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga     1260

ggctggggaa atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt     1320

gcatgctcca agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata     1380

atgctgtcag ttcatggctc ccagcacagt gggatgattg ttaatgacac aggacatgaa     1440

actgatgaga atagagcgaa agttgagata acgcccaatt caccaagagc cgaagccacc     1500

ctggggggtt ttggaagcct aggacttgat tgtgaaccga ggacaggcct tgacttttca     1560

gatttgtatt acttgactat gaataacaag cactggttgg ttcacaagga gtggttccac     1620

gacattccat taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa     1680

gaagcactgg tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg     1740

agtcaagaag gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt     1800

gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga     1860

ttgaagggcg tgtcatactc cttgtgtact gcagcgttca cattcaccaa gatcccggct     1920

gaaacactgc acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc     1980

aaggttccag ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata     2040

accgctaacc ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat     2100

ccaccatttg gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac     2160

tggcacagga gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag     2220

agaatggcag tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac     2280

tcattgggca agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga     2340

atgtcctggt tctcacaaat tctcattgga acgttgctga tgtggttggg tctgaacaca     2400

aagaatggat ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc     2460

acagccgtct ctgctgatgt ggggtgctcg gtggacttct caaagaagga gacgagatgc     2520

ggtacagggg tgttcgtcta taacgacgtt gaagcctgga gggacaggta caagtaccat     2580

cctgactccc cccgtagatt ggcagcagca gtcaagcaag cctgggaaga tggtatctgc     2640

gggatctcct ctgtttcaag aatggaaaac atcatgtgga gatcagtaga aggggagctc     2700

aacgcaatcc tggaagagaa tggagttcaa ctgacggtcg ttgtgggatc tgtaaaaaac     2760

cccatgtgga gaggtccaca gagattgccc gtgcctgtga acgagctgcc ccacggctgg     2820

aaggcttggg ggaaatcgta cttcgtcaga gcagcaaaga caaataacag ctttgtcgtg     2880

gatggtgaca cactgaagga atgcccactc aaacatagag catggaacag ctttcttgtg     2940

gaggatcatg ggttcggggt atttcacact agtgtctggc tcaaggttag agaagattat     3000

tcattagagt gtgatccagc cgttattgga acagctgtta agggaaagga ggctgtacac     3060

agtgatctag gctactggat tgagagtgag aagaatgaca catggaggct gaagagggcc     3120

catctgatcg agatgaaaac atgtgaatgg ccaaagtccc acacattgtg gacagatgga     3180

atagaagaga gtgatctgat catacccaag tctttagctg ggccactcag ccatcacaat     3240

accagagagg gctacaggac ccaaatgaaa gggccatggc acagtgaaga gcttgaaatt     3300

cggtttgagg aatgcccagg cactaaggtc cacgtggagg aaacatgtgg aacaagagga     3360

ccatctctga gatcaaccac tgcaagcgga agggtgatcg aggaatggtg ctgcagggag     3420

tgcacaatgc ccccactgtc gttccgggct aaagatggct gttggtatgg aatggagata     3480

aggcccagga aagaaccaga aagcaactta gtaaggtcaa tggtgactgc aggatcaact     3540

gatcacatgg accacttctc ccttggagtg cttgtgattc tgctcatggt gcaggaaggg     3600

ctgaagaaga gaatgaccac aaagatcatc ataagcacat caatggcagt gctggtagct     3660

atgatcctgg gaggattttc aatgagtgac ctggctaagc ttgcaatttt gatgggtgcc     3720

accttcgcgg aaatgaacac tggaggagat gtagctcatc tggcgctgat agcggcattc     3780

aaagtcagac cagcgttgct ggtatctttc atcttcagag ctaattggac accccgtgaa     3840

agcatgctgc tggccttggc ctcgtgtctt ttgcaaactg cgatctccgc cttggaaggc     3900

gacctgatgg ttctcatcaa tggttttgct ttggcctggt tggcaatacg agcgatggtt     3960

gttccacgca ctgataacat caccttggca atcctggctg ctctgacacc actggcccgg     4020

ggcacactgc ttgtggcgtg gagagcaggc cttgctactt gcggggggtt tatgctcctc     4080

tctctgaagg gaaaaggcag tgtgaagaag aacttaccat ttgtcatggc cctgggacta     4140

accgctgtga ggctggtcga ccccatcaac gtggtgggac tgctgttgct cacaaggagt     4200

gggaagcgga gctggccccc tagcgaagta ctcacagctg ttggcctgat atgcgcattg     4260

gctggagggt tcgccaaggc agatatagag atggctgggc ccatggccgc ggtcggtctg     4320

ctaattgtca gttacgtggt ctcaggaaag agtgtggaca tgtacattga aagagcaggt     4380

gacatcacat gggaaaaaga tgcggaagtc actggaaaca gtccccggct cgatgtggcg     4440

ctagatgaga gtggtgattt ctccctggtg gaggatgacg gtccccccat gagagagatc     4500

atactcaagg tggtcctgat gaccatctgt ggcatgaacc caatagccat accctttgca     4560

gctggagcgt ggtacgtata cgtgaagact ggaaaaagga gtggtgctct atgggatgtg     4620

cctgctccca aggaagtaaa aaagggggag accacagatg gagtgtacag agtaatgact     4680

cgtagactgc taggttcaac acaagttgga gtgggagtta tgcaagaggg ggtctttcac     4740

actatgtggc acgtcacaaa aggatccgcg ctgagaagcg gtgaagggag acttgatcca     4800

tactggggag atgtcaagca ggatctggtg tcatactgtg gtccatggaa gctagatgcc     4860

gcctgggacg ggcacagcga ggtgcagctc ttggccgtgc cccccggaga gagagcgagg     4920

aacatccaga ctctgcccgg aatatttaag acaaaggatg gggacattgg agcggttgcg     4980

ctggattacc cagcaggaac ttcaggatct ccaatcctag acaagtgtgg gagagtgata     5040

ggactttatg gcaatggggt cgtgatcaaa aatgggagtt atgttagtgc catcacccaa     5100

gggaggaggg aggaagagac tcctgttgag tgcttcgagc cttcgatgct gaagaagaag     5160

cagctaactg tcttagactt gcatcctgga gctgggaaaa ccaggagagt tcttcctgaa     5220

atagtccgtg aagccataaa aacaagactc cgcaccgtga tcttagctcc aaccagggtt     5280

gtcgctgctg aaatggagga ggcccttaga gggcttccag tgcgttatat gacaacagca     5340

gtcaatgtca cccactctgg aacagaaatc gtcgacttaa tgtgccatgc caccttcact     5400

tcacgtctac tacagccaat cagagtcccc aactataatc tgtatattat ggatgaggcc     5460

cacttcacag atccctcaag tatagcagca agaggataca tttcaacaag ggttgagatg     5520

ggcgaggcgg ctgccatctt catgaccgcc acgccaccag gaacccgtga cgcatttccg     5580

gactccaact caccaattat ggacaccgaa gtggaagtcc cagagagagc ctggagctca     5640

ggctttgatt gggtgacgga tcattctgga aaaacagttt ggtttgttcc aagcgtgagg     5700

aacggcaatg agatcgcagc ttgtctgaca aaggctggaa aacgggtcat acagctcagc     5760

agaaagactt ttgagacaga gttccagaaa acaaaacatc aagagtggga ctttgtcgtg     5820

acaactgaca tttcagagat gggcgccaac tttaaagctg accgtgtcat agattccagg     5880

agatgcctaa agccggtcat acttgatggc gagagagtca ttctggctgg acccatgcct     5940

gtcacacatg ccagcgctgc ccagaggagg gggcgcatag gcaggaatcc caacaaacct     6000

ggagatgagt atctgtatgg aggtgggtgc gcagagactg acgaagacca tgcacactgg     6060

cttgaagcaa gaatgctcct tgacaatatt tacctccaag atggcctcat agcctcgctc     6120

tatcgacctg aggccgacaa agtagcagcc attgagggag agttcaagct taggacggag     6180

caaaggaaga cctttgtgga actcatgaaa agaggagatc ttcctgtttg gctggcctat     6240

caggttgcat ctgccggaat aacctacaca gatagaagat ggtgctttga tggcacgacc     6300

aacaacacca taatggaaga cagtgtgccg gcagaggtgt ggaccagaca cggagagaaa     6360

agagtgctca aaccgaggtg gatggacgcc agagtttgtt cagatcatgc ggccctgaag     6420

tcattcaagg agtttgccgc tgggaaaaga ggagcggctt ttggagtgat ggaagccctg     6480

ggaacactgc caggacacat gacagagaga ttccaggaag ccattgacaa cctcgctgtg     6540

ctcatgcggg cagagactgg aagcaggcct tacaaagccg cggcggccca attgccggag     6600

accctagaga ccattatgct tttggggttg ctgggaacag tctcgctggg aatcttcttc     6660

gtcttgatga ggaacaaggg catagggaag atgggctttg gaatggtgac tcttggggcc     6720

agcgcatggc tcatgtggct ctcggaaatt gagccagcca gaattgcatg tgtcctcatt     6780

gttgtgtttc tattgctggt ggtgctcata cctgagccag aaaagcaaag atctccccag     6840

gacaaccaaa tggcaatcat catcatggta gcagtaggtc ttctgggctt gattaccgcc     6900

aatgaactcg gatggttgga gagaacaaag agtgacctaa gccatctaat gggaaggaga     6960

gaggaggggg caaccatagg attctcaatg gacattgacc tgcggccagc ctcagcttgg     7020

gccatctatg ctgccttgac aactttcatt accccagccg tccaacatgc agtgaccact     7080

tcatacaaca actactcctt aatggcgatg gccacgcaag ctggagtgtt gtttggtatg     7140

ggcaaaggga tgccattcta cgcatgggac tttggagtcc cgctgctaat gataggttgc     7200

tactcacaat taacacccct gaccctaata gtggccatca ttttgctcgt ggcgcactac     7260

atgtacttga tcccagggct gcaggcagca gctgcgcgtg ctgcccagaa gagaacggca     7320

gctggcatca tgaagaaccc tgttgtggat ggaatagtgg tgactgacat tgacacaatg     7380

acaattgacc cccaagtgga gaaaaagatg ggacaggtgc tactcatagc agtagccgtc     7440

tccagcgcca tactgtcgcg gaccgcctgg gggtgggggg aggctggggc cctgatcaca     7500

gccgcaactt ccactttgtg ggaaggctct ccgaacaagt actggaactc ctctacagcc     7560

acttcactgt gtaacatttt taggggaagt tacttggctg gagcttctct aatctacaca     7620

gtaacaagaa acgctggctt ggtcaagaga cgtgggggtg gaacaggaga gaccctggga     7680

gagaaatgga aggcccgctt gaaccagatg tcggccctgg agttctactc ctacaaaaag     7740

tcaggcatca ccgaggtgtg cagagaagag gcccgccgcg ccctcaagga cggtgtggca     7800

acgggaggcc atgctgtgtc ccgaggaagt gcaaagctga gatggttggt ggagcgggga     7860

tacctgcagc cctatggaaa ggtcattgat cttggatgtg gcagaggggg ctggagttac     7920

tacgccgcca ccatccgcaa agttcaagaa gtgaaaggat acacaaaagg aggccctggt     7980

catgaagaac ccgtgttggt gcaaagctat gggtggaaca tagtccgtct taagagtggg     8040

gtggacgtct ttcatatggc ggctgagccg tgtgacacgt tgctgtgtga cataggtgag     8100

tcatcatcta gtcctgaagt ggaagaagca cggacgctca gagtcctctc catggtgggg     8160

gattggcttg aaaaaagacc aggagccttt tgtataaagg tgttgtgccc atacaccagc     8220

actatgatgg aaaccctgga gcgactgcag cgtaggtatg ggggaggact ggtcagagtg     8280

ccactctccc gcaactctac acatgagatg tattgggtct ctggagcgaa aagcaacacc     8340

ataaaaagtg tgtccaccac gagccagctc ctcttggggc gcatggacgg gcctaggagg     8400

ccagtgaaat atgaggagga tgtggatctc ggctctggca cgcgggctgt ggtaagctgc     8460

gctgaagctc ccaacatgaa gatcattggt aaccgcattg aaaggatccg cagtgagcac     8520

gcggaaacgt ggttctttga cgagaaccac ccatatagga catgggctta ccatggaagc     8580

tatgaggccc ccacacaagg gtcagcgtcc tctctaataa acggggttgt caggctcctg     8640

tcaaaaccct gggatgtggt gactggagtc acaggaatag ccatgaccga caccacaccg     8700

tatggtcagc aaagagtttt caaggaaaaa gtggacacta gggtgccaga cccccaagaa     8760

ggcactcgtc aggttatgag catggtctct tcctggttgt ggaaagagct aggcaaacac     8820

aaacggccac gagtctgtac caaagaagag ttcatcaaca aggttcgtag caatgcagca     8880

ttaggggcaa tatttgaaga ggaaaaagag tggaagactg cagtggaagc tgtgaacgat     8940

ccaaggttct gggctctagt ggataaggaa agagagcacc acctgagagg agagtgccag     9000

agttgtgtgt acaacatgat gggaaaaaga gaaaagaaac aaggggaatt tggaaaggcc     9060

aagggcagcc gcgccatctg gtatatgtgg ctaggggcta gatttctaga gttcgaagcc     9120

cttggattct tgaacgagga tcactggatg gggagagaga actcaggagg tggtgttgaa     9180

gggctgggat tacaaagact cggatatgtc ctagaagaga tgagtcgtat accaggagga     9240

aggatgtatg cagatgacac tgctggctgg gacacccgca tcagcaggtt tgatctggag     9300

aatgaagctc taatcaccaa ccaaatggaa aaagggcaca gggccttggc attggccata     9360

atcaagtaca cataccaaaa caaagtggta aaggtcctta gaccagctga aaaagggaaa     9420

acagttatgg acattatttc gagacaagac caaaggggga gcggacaagt tgtcacttac     9480

gctcttaaca catttaccaa cctagtggtg caactcattc ggaatatgga ggctgaggaa     9540

gttctagaga tgcaagactt gtggctgctg cggaggtcag agaaagtgac caactggttg     9600

cagagcaacg gatgggatag gctcaaacga atggcagtca gtggagatga ttgcgttgtg     9660

aagccaattg atgataggtt tgcacatgcc ctcaggttct tgaatgatat gggaaaagtt     9720

aggaaggaca cacaagagtg gaaaccctca actggatggg acaactggga agaagttccg     9780

ttttgctccc accacttcaa caagctccat ctcaaggacg ggaggtccat tgtggttccc     9840

tgccgccacc aagatgaact gattggccgg gcccgcgtct ctccaggggc gggatggagc     9900

atccgggaga ctgcttgcct agcaaaatca tatgcgcaaa tgtggcagct cctttatttc     9960

cacagaaggg acctccgact gatggccaat gccatttgtt catctgtgcc agttgactgg    10020

gttccaactg ggagaactac ctggtcaatc catggaaagg gagaatggat gaccactgaa    10080

gacatgcttg tggtgtggaa cagagtgtgg attgaggaga acgaccacat ggaagacaag    10140

accccagtta cgaaatggac agacattccc tatttgggaa aaagggaaga cttgtggtgt    10200

ggatctctca tagggcacag accgcgcacc acctgggctg agaacattaa aaacacagtc    10260

aacatggtgc gcaggatcat aggtgatgaa gaaaagtaca tggactacct atccacccaa    10320

gttcgctact tgggtgaaga agggtctaca cctggagtgc tgtaagcacc aatcttaatg    10380

ttgtcaggcc tgctagtcag ccacagcttg gggaaagctg tgcagcctgt gaccccccag    10440

gagaagctgg gaaaccaagc ctatagtcag gccgagaacg ccatggcacg gaagaagcca    10500

tgctgcctgt gagcccctca gaggacactg agtcaaaaaa ccccacgcgc ttggaggcgc    10560

aggatgggaa aagaaggtgg cgaccttccc cacccttcaa tctggggcct gaactggaga    10620

tcagctgtgg atctccagaa gagggactag tggttagagg ag                       10662


<210>  11
<211>  10662
<212>  DNA
<213>  Zika virus strain BeH819966 polyprotein gene

<400>  11
gtgaatcaga ctgcgacagt tcgagtttga agcgaaagct agcaacagta tcaacaggtt       60

ttattttgga tttggaaacg agagtttctg gtcatgaaaa acccaaaaaa gaaatccgga      120

ggattccgga ttgtcaatat gctaaaacgc ggagtagccc gtgtgagccc ctttgggggc      180

ttgaagaggc tgccagccgg acttctgctg ggtcatgggc ccatcaggat ggtcttggcg      240

attctagcct ttttgagatt cacggcaatc aagccatcac tgggtctcat caatagatgg      300

ggttcagtgg ggaaaaaaga ggctatggaa ataataaaga agttcaagaa agatctggct      360

gccatgctga gaataatcaa tgctaggaag gagaagaaga gacgaggcgc agatactagt      420

gtcggaattg ttggcctcct gctgaccaca gctatggcag cggaggtcac tagacgtggg      480

agtgcatact atatgtactt ggacagaaac gatgctgggg aggccatatc ttttccaacc      540

acattgggga tgaataagtg ttatatacag atcatggatc ttggacacat gtgtgatgcc      600

accatgagct atgaatgccc tatgctggat gagggggtgg aaccagatga cgtcgattgt      660

tggtgcaaca cgacgtcaac ttgggttgtg tacggaacct gccatcacaa aaaaggtgaa      720

gcacggagat ctagaagagc tgtgacgctc ccctcccatt ccactaggaa gctgcaaacg      780

cggtcgcaaa cctggttgga atcaagagaa tacacaaagc acttgattag agtcgaaaat      840

tggatattca ggaaccctgg cttcgcgtta gcagcagctg ccatcgcttg gcttttggga      900

agctcaacga gccaaaaagt catatacttg gtcatgatac tgctgattgc cccggcatac      960

agcatcaggt gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggacc     1020

tgggttgatg ttgtcttgga acatggaggt tgtgtcaccg taatggcaca ggacaaaccg     1080

actgtcgaca tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac     1140

tgctatgagg catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa     1200

gcctaccttg acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga     1260

ggctggggaa atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt     1320

gcatgctcca agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata     1380

atgctgtcag ttcatggctc ccagcacagt gggatgattg ttaatgacac aggacatgaa     1440

actgatgaga atagagcgaa agttgagata acgcccaatt caccaagagc cgaagccacc     1500

ctggggggtt ttggaagcct aggacttgat tgtgaaccga ggacaggcct tgacttttca     1560

gatttgtatt acttgactat gaataacaag cactggttgg ttcacaagga gtggttccac     1620

gacattccat taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa     1680

gaagcactgg tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg     1740

agtcaagaag gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt     1800

gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga     1860

ttgaagggcg tgtcatactc cttgtgtact gcagcgttca cattcaccaa gatcccggct     1920

gaaacactgc acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc     1980

aaggttccag ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata     2040

accgctaacc ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat     2100

ccaccatttg gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac     2160

tggcacagga gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag     2220

agaatggcag tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac     2280

tcattgggca agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga     2340

atgtcctggt tctcacaaat tctcattgga acgttgctga tgtggttggg tctgaacaca     2400

aagaatggat ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc     2460

acagccgtct ctgctgatgt ggggtgctcg gtggacttct caaagaagga gacgagatgc     2520

ggtacagggg tgttcgtcta taacgacgtt gaagcctgga gggacaggta caagtaccat     2580

cctgactccc cccgtagatt ggcagcagca gtcaagcaag cctgggaaga tggtatctgc     2640

gggatctcct ctgtttcaag aatggaaaac atcatgtgga gatcagtaga aggggagctc     2700

aacgcaatcc tggaagagaa tggagttcaa ctgacggtcg ttgtgggatc tgtaaaaaac     2760

cccatgtgga gaggtccaca gagattgccc gtgcctgtga acgagctgcc ccacggctgg     2820

aaggcttggg ggaaatcgta cttcgtcaga gcagcaaaga caaataacag ctttgtcgtg     2880

gatggtgaca cactgaagga atgcccactc aaacatagag catggaacag ctttcttgtg     2940

gaggatcatg ggttcggggt atttcacact agtgtctggc tcaaggttag agaagattat     3000

tcattagagt gtgatccagc cgttattgga acagctgtta agggaaagga ggctgtacac     3060

agtgatctag gctactggat tgagagtgag aagaatgaca catggaggct gaagagggcc     3120

catctgatcg agatgaaaac atgtgaatgg ccaaagtccc acacattgtg gacagatgga     3180

atagaagaga gtgatctgat catacccaag tctttagctg ggccactcag ccatcacaat     3240

accagagagg gctacaggac ccaaatgaaa gggccatggc acagtgaaga gcttgaaatt     3300

cggtttgagg aatgcccagg cactaaggtc cacgtggagg aaacatgtgg aacaagagga     3360

ccatctctga gatcaaccac tgcaagcgga agggtgatcg aggaatggtg ctgcagggag     3420

tgcacaatgc ccccactgtc gttccgggct aaagatggct gttggtatgg aatggagata     3480

aggcccagga aagaaccaga aagcaactta gtaaggtcaa tggtgactgc aggatcaact     3540

gatcacatgg accacttctc ccttggagtg cttgtgattc tgctcatggt gcaggaaggg     3600

ctgaagaaga gaatgaccac aaagatcatc ataagcacat caatggcagt gctggtagct     3660

atgatcctgg gaggattttc aatgagtgac ctggctaagc ttgcaatttt gatgggtgcc     3720

accttcgcgg aaatgaacac tggaggagat gtagctcatc tggcgctgat agcggcattc     3780

aaagtcagac cagcgttgct ggtatctttc atcttcagag ctaattggac accccgtgaa     3840

agcatgctgc tggccttggc ctcgtgtctt ttgcaaactg cgatctccgc cttggaaggc     3900

gacctgatgg ttctcatcaa tggttttgct ttggcctggt tggcaatacg agcgatggtt     3960

gttccacgca ctgataacat caccttggca atcctggctg ctctgacacc actggcccgg     4020

ggcacactgc ttgtggcgtg gagagcaggc cttgctactt gcggggggtt tatgctcctc     4080

tctctgaagg gaaaaggcag tgtgaagaag aacttaccat ttgtcatggc cctgggacta     4140

accgctgtga ggctggtcga ccccatcaac gtggtgggac tgctgttgct cacaaggagt     4200

gggaagcgga gctggccccc tagcgaagta ctcacagctg ttggcctgat atgcgcattg     4260

gctggagggt tcgccaaggc agatatagag atggctgggc ccatggccgc ggtcggtctg     4320

ctaattgtca gttacgtggt ctcaggaaag agtgtggaca tgtacattga aagagcaggt     4380

gacatcacat gggaaaaaga tgcggaagtc actggaaaca gtccccggct cgatgtggcg     4440

ctagatgaga gtggtgattt ctccctggtg gaggatgacg gtccccccat gagagagatc     4500

atactcaagg tggtcctgat gaccatctgt ggcatgaacc caatagccat accctttgca     4560

gctggagcgt ggtacgtata cgtgaagact ggaaaaagga gtggtgctct atgggatgtg     4620

cctgctccca aggaagtaaa aaagggggag accacagatg gagtgtacag agtaatgact     4680

cgtagactgc taggttcaac acaagttgga gtgggagtta tgcaagaggg ggtctttcac     4740

actatgtggc acgtcacaaa aggatccgcg ctgagaagcg gtgaagggag acttgatcca     4800

tactggggag atgtcaagca ggatctggtg tcatactgtg gtccatggaa gctagatgcc     4860

gcctgggacg ggcacagcga ggtgcagctc ttggccgtgc cccccggaga gagagcgagg     4920

aacatccaga ctctgcccgg aatatttaag acaaaggatg gggacattgg agcggttgcg     4980

ctggattacc cagcaggaac ttcaggatct ccaatcctag acaagtgtgg gagagtgata     5040

ggactttatg gcaatggggt cgtgatcaaa aatgggagtt atgttagtgc catcacccaa     5100

gggaggaggg aggaagagac tcctgttgag tgcttcgagc cttcgatgct gaagaagaag     5160

cagctaactg tcttagactt gcatcctgga gctgggaaaa ccaggagagt tcttcctgaa     5220

atagtccgtg aagccataaa aacaagactc cgtactgtga tcttagctcc aaccagggtt     5280

gtcgctgctg aaatggagga ggcccttaga gggcttccag tgcgttatat gacaacagca     5340

gtcaatgtca cccactctgg aacagaaatc gtcgacttaa tgtgccatgc caccttcact     5400

tcacgtctac tacagccaat cagagtcccc aactataatc tgtatattat ggatgaggcc     5460

cacttcacag atccctcaag tatagcagca agaggataca tttcaacaag ggttgagatg     5520

ggcgaggcgg ctgccatctt catgaccgcc acgccaccag gaacccgtga cgcatttccg     5580

gactccaact caccaattat ggacaccgaa gtggaagtcc cagagagagc ctggagctca     5640

ggctttgatt gggtgacgga tcattctgga aaaacagttt ggtttgttcc aagcgtgagg     5700

aacggcaatg agatcgcagc ttgtctgaca aaggctggaa aacgggtcat acagctcagc     5760

agaaagactt ttgagacaga gttccagaaa acaaaacatc aagagtggga ctttgtcgtg     5820

acaactgaca tttcagagat gggcgccaac tttaaagctg accgtgtcat agattccagg     5880

agatgcctaa agccggtcat acttgatggc gagagagtca ttctggctgg acccatgcct     5940

gtcacacatg ccagcgctgc ccagaggagg gggcgcatag gcaggaatcc caacaaacct     6000

ggagatgagt atctgtatgg aggtgggtgc gcagagactg acgaagacca tgcacactgg     6060

cttgaagcaa gaatgctcct tgacaatatt tacctccaag atggcctcat agcctcgctc     6120

tatcgacctg aggccgacaa agtagcagcc attgagggag agttcaagct taggacggag     6180

caaaggaaga cctttgtgga actcatgaaa agaggagatc ttcctgtttg gctggcctat     6240

caggttgcat ctgccggaat aacctacaca gatagaagat ggtgctttga tggcacgacc     6300

aacaacacca taatggaaga cagtgtgccg gcagaggtgt ggaccagaca cggagagaaa     6360

agagtgctca aaccgaggtg gatggacgcc agagtttgtt cagatcatgc ggccctgaag     6420

tcattcaagg agtttgccgc tgggaaaaga ggagcggctt ttggagtgat ggaagccctg     6480

ggaacactgc caggacacat gacagagaga ttccaggaag ccattgacaa cctcgctgtg     6540

ctcatgcggg cagagactgg aagcaggcct tacaaagccg cggcggccca attgccggag     6600

accctagaga ccattatgct tttggggttg ctgggaacag tctcgctggg aatcttcttc     6660

gtcttgatga ggaacaaggg catagggaag atgggctttg gaatggtgac tcttggggcc     6720

agcgcatggc tcatgtggct ctcggaaatt gagccagcca gaattgcatg tgtcctcatt     6780

gttgtgtttc tattgctggt ggtgctcata cctgagccag aaaagcaaag atctccccag     6840

gacaaccaaa tggcaatcat catcatggta gcagtaggtc ttctgggctt gattaccgcc     6900

aatgaactcg gatggttgga gagaacaaag agtgacctaa gccatctaat gggaaggaga     6960

gaggaggggg caaccatagg attctcaatg gacattgacc tgcggccagc ctcagcttgg     7020

gccatctatg ctgccttgac aactttcatt accccagccg tccaacatgc agtgaccact     7080

tcatacaaca actactcctt aatggcgatg gccacgcaag ctggagtgtt gtttggtatg     7140

ggcaaaggga tgccattcta cgcatgggac tttggagtcc cgctgctaat gataggttgc     7200

tactcacaat taacacccct gaccctaata gtggccatca ttttgctcgt ggcgcactac     7260

atgtacttga tcccagggct gcaggcagca gctgcgcgtg ctgcccagaa gagaacggca     7320

gctggcatca tgaagaaccc tgttgtggat ggaatagtgg tgactgacat tgacacaatg     7380

acaattgacc cccaagtgga gaaaaagatg ggacaggtgc tactcatagc agtagccgtc     7440

tccagcgcca tactgtcgcg gaccgcctgg gggtgggggg aggctggggc cctgatcaca     7500

gccgcaactt ccactttgtg ggaaggctct ccgaacaagt actggaactc ctctacagcc     7560

acttcactgt gtaacatttt taggggaagt tacttggctg gagcttctct aatctacaca     7620

gtaacaagaa acgctggctt ggtcaagaga cgtgggggtg gaacaggaga gaccctggga     7680

gagaaatgga aggcccgctt gaaccagatg tcggccctgg agttctactc ctacaaaaag     7740

tcaggcatca ccgaggtgtg cagagaagag gcccgccgcg ccctcaagga cggtgtggca     7800

acgggaggcc atgctgtgtc ccgaggaagt gcaaagctga gatggttggt ggagcgggga     7860

tacctgcagc cctatggaaa ggtcattgat cttggatgtg gcagaggggg ctggagttac     7920

tacgccgcca ccatccgcaa agttcaagaa gtgaaaggat acacaaaagg aggccctggt     7980

catgaagaac ccgtgttggt gcaaagctat gggtggaaca tagtccgtct taagagtggg     8040

gtggacgtct ttcatatggc ggctgagccg tgtgacacgt tgctgtgtga cataggtgag     8100

tcatcatcta gtcctgaagt ggaagaagca cggacgctca gagtcctctc catggtgggg     8160

gattggcttg aaaaaagacc aggagccttt tgtataaagg tgttgtgccc atacaccagc     8220

actatgatgg aaaccctgga gcgactgcag cgtaggtatg ggggaggact ggtcagagtg     8280

ccactctccc gcaactctac acatgagatg tattgggtct ctggagcgaa aagcaacacc     8340

ataaaaagtg tgtccaccac gagccagctc ctcttggggc gcatggacgg gcctaggagg     8400

ccagtgaaat atgaggagga tgtgaatctc ggctctggca cgcgggctgt ggtaagctgc     8460

gctgaagctc ccaacatgaa gatcattggt aaccgcattg aaaggatccg cagtgagcac     8520

gcggaaacgt ggttctttga cgagaaccac ccatatagga catgggctta ccatggaagc     8580

tatgaggccc ccacacaagg gtcagcgtcc tctctaataa acggggttgt caggctcctg     8640

tcaaaaccct gggatgtggt gactggagtc acaggaatag ccatgaccga caccacaccg     8700

tatggtcagc aaagagtttt caaggaaaaa gtggacacta gggtgccaga cccccaagaa     8760

ggcactcgtc aggttatgag catggtctct tcctggttgt ggaaagagct aggcaaacac     8820

aaacggccac gagtctgtac caaagaagag ttcatcaaca aggttcgtag caatgcagca     8880

ttaggggcaa tatttgaaga ggaaaaagag tggaagactg cagtggaagc tgtgaacgat     8940

ccaaggttct gggctctagt ggataaggaa agagagcacc acctgagagg agagtgccag     9000

agttgtgtgt acaacatgat gggaaaaaga gaaaagaaac aaggggaatt tggaaaggcc     9060

aagggcagcc gcgccatctg gtatatgtgg ctaggggcta gatttctaga gttcgaagcc     9120

cttggattct tgaacgagga tcactggatg gggagagaga actcaggagg tggtgttgaa     9180

gggctgggat tacaaagact cggatatgtc ctagaagaga tgagtcgtat accaggagga     9240

aggatgtatg cagatgacac tgctggctgg gacacccgca tcagcaggtt tgatctggag     9300

aatgaagctc taatcaccaa ccaaatggaa aaagggcaca gggccttggc attggccata     9360

atcaagtaca cataccaaaa caaagtggta aaggtcctta gaccagctga aaaagggaaa     9420

acagttatgg acattatttc gagacaagac caaaggggga gcggacaagt tgtcacttac     9480

gctcttaaca catttaccaa cctagtggtg caactcattc ggaatatgga ggctgaggaa     9540

gttctagaga tgcaagactt gtggctgctg cggaggtcag agaaagtgac caactggttg     9600

cagagcaacg gatgggatag gctcaaacga atggcagtca gtggagatga ttgcgttgtg     9660

aagccaattg atgataggtt tgcacatgcc ctcaggttct tgaatgatat gggaaaagtt     9720

aggaaggaca cacaagagtg gaaaccctca actggatggg acaactggga agaagttccg     9780

ttttgctccc accacttcaa caagctccat ctcaaggacg ggaggtccat tgtggttccc     9840

tgccgccacc aagatgaact gattggccgg gcccgcgtct ctccaggggc gggatggagc     9900

atccgggaga ctgcttgcct agcaaaatca tatgcgcaaa tgtggcagct cctttatttc     9960

cacagaaggg acctccgact gatggccaat gccatttgtt catctgtgcc agttgactgg    10020

gttccaactg ggagaactac ctggtcaatc catggaaagg gagaatggat gaccactgaa    10080

gacatgcttg tggtgtggaa cagagtgtgg attgaggaga acgaccacat ggaagacaag    10140

accccagtta cgaaatggac agacatcccc tatttgggaa aaagggaaga cttgtggtgt    10200

ggatctctca tagggcacag accgcgcacc acctgggctg agaacattaa aaacacagtc    10260

aacatggtgc gcaggatcat aggtgatgaa gaaaagtaca tggactacct atccacccaa    10320

gttcgctact tgggtgaaga agggtctaca cctggagtgc tgtaagcacc agtcttaatg    10380

ttgtcaggcc tgctagtcag ccacagcttg gggaaagctg tgcagcctgt gaccccccag    10440

gagaagctgg gaaaccaagc ctatagtcag gccgagaacg ccatggcacg gaagaagcca    10500

tgctgcctgt gagcccctca gaggacactg agtcaaaaaa ccccacgcgc ttggaggcgc    10560

aggatgggaa aagaaggtgg cgaccttccc cacccttcaa tctggggcct gaactggaga    10620

tcagctgtgg atctccagaa gagggactag tggttagagg ag                       10662


<210>  12
<211>  10727
<212>  DNA
<213>  Zika virus strain BeH819015 polyprotein gene

<400>  12
tgtgaatcag actgcgacag ttcgagtttg aagcgaaagc tagcaacagt atcaacaggt       60

tttattttgg atttggaaac gagagtttct ggtcatgaaa aacccaaaaa agaaatccgg      120

aggattccgg attgtcaata tgctaaaacg cggagtagcc cgtgtgagcc cctttggggg      180

cttgaagagg ctgccagccg gacttctgct gggtcatggg cccatcagga tggtcttggc      240

gattctagcc tttttgagat tcacggcaat caagccatca ctgggtctca tcaatagatg      300

gggttcagtt gggaaaaaag aggctatgga aataataaag aagttcaaga aagatctggc      360

tgccatgctg agaataatca atgctaggaa ggagaagaag agacgaggcg cagatactag      420

tgtcggaatt gttggcctcc tgctgaccac agctatggca gcggaggtca ctagacgtgg      480

gagtgcatac tatatgtact tggacagaaa cgatgctggg gaggccatat cttttccaac      540

cacattgggg atgaataagt gttatataca gatcatggat cttggacaca tgtgtgatgc      600

caccatgagc tatgaatgcc ctatgctgga tgagggggtg gaaccagatg acgtcgattg      660

ttggtgcaac acgacgtcaa cttgggttgt gtacggaacc tgccatcaca aaaaaggtga      720

agcacggaga tctagaagag ctgtgacgct cccctcccat tccactagga agctgcaaac      780

gcggtcgcaa acctggttgg aatcaagaga atacacaaag cacttgatta gagtcgaaaa      840

ttggatattc aggaaccctg gcttcgcgtt agcagcagct gccatcgctt ggcttttggg      900

aagctcaacg agccaaaaag tcatatactt ggtcatgata ctgctgattg ccccggcata      960

cagcatcagg tgcataggag tcagcaatag ggactttgtg gaaggtatgt caggtgggac     1020

ttgggttgat gttgtcttgg aacatggagg ttgtgtcacc gtaatggcac aggacaaacc     1080

gactgtcgac atagagctgg ttacaacaac agtcagcaac atggcggagg taagatccta     1140

ctgctatgag gcatcaatat cagacatggc ttcggacagc cgctgcccaa cacaaggtga     1200

agcctacctt gacaagcaat cagacactca atatgtctgc aaaagaacgt tagtggacag     1260

aggctgggga aatggatgtg gactttttgg caaagggagc ctggtgacat gcgctaagtt     1320

tgcatgctcc aagaaaatga ccgggaagag catccagcca gagaatctgg agtaccggat     1380

aatgctgtca gttcatggct cccagcacag tgggatgatc gttaatgaca caggacatga     1440

aactgatgag aatagagcga aagttgagat aacgcccaat tcaccaagag ccgaagccac     1500

cctggggggt tttggaagcc taggacttga ttgtgaaccg aggacaggcc ttgacttttc     1560

agatttgtat tacttgacta tgaataacaa gcactggttg gttcacaagg agtggttcca     1620

cgacattcca ttaccttggc acgctggggc agacaccgga actccacact ggaacaacaa     1680

agaagcactg gtagagttca aggacgcaca tgccaaaagg caaactgtcg tggttctagg     1740

gagtcaagaa ggagcagttc acacggccct tgctggagct ctggaggctg agatggatgg     1800

tgcaaaggga aggctgtcct ctggccactt gaaatgtcgc ctgaaaatgg ataaacttag     1860

attgaagggc gtgtcatact ccttgtgtac tgcagcgttc acattcacca agatcccggc     1920

tgaaacactg cacgggacag tcacagtgga ggtacagtac gcagggacag atggaccttg     1980

caaggttcca gctcagatgg cggtggacat gcaaactctg accccagttg ggaggttgat     2040

aaccgctaac cccgtaatca ctgaaagcac tgagaactct aagatgatgc tggaacttga     2100

tccaccattt ggggactctt acattgtcat aggagtcggg gagaagaaga tcacccacca     2160

ctggcacagg agtggcagca ccattggaaa agcatttgaa gccactgtga gaggtgccaa     2220

gagaatggca gtcttgggag acacagcctg ggactttgga tcagttggag gcgctctcaa     2280

ctcattgggc aagggcatcc atcaaatttt tggagcagct ttcaaatcat tgtttggagg     2340

aatgtcctgg ttctcacaaa ttctcattgg aacgttgctg atgtggttgg gtctgaacac     2400

aaagaatgga tctatttccc ttatgtgctt ggccttaggg ggggtgttga tcttcttatc     2460

cacagccgtc tctgctgatg tggggtgctc ggtggacttc tcaaagaagg agacgagatg     2520

cggtacaggg gtgttcgtct ataacgacgt tgaagcctgg agggacaggt acaagtacca     2580

tcctgactcc ccccgtagat tggcagcagc agtcaagcaa gcctgggaag atggtatctg     2640

cgggatctcc tctgtttcaa gaatggaaaa catcatgtgg agatcagtag aaggggagct     2700

caacgcaatc ctggaagaga atggagttca actgacggtc gttgtgggat ctgtaaaaaa     2760

ccccatgtgg agaggtccac agagattgcc cgtgcctgtg aacgagctgc cccacggctg     2820

gaaggcttgg gggaaatcgt acttcgtcag agcagcaaag acaaataaca gctttgtcgt     2880

ggatggtgac acactgaagg aatgcccact caaacataga gcatggaaca gctttcttgt     2940

ggaggatcat gggttcgggg tatttcacac tagtgtctgg ctcaaggtta gagaagatta     3000

ttcattagag tgtgatccag ccgttattgg aacagctgtt aagggaaagg aggctgtaca     3060

cagtgatcta ggctactgga ttgagagtga gaagaatgac acatggaggc tgaagagggc     3120

ccatctgatc gagatgaaaa catgtgaatg gccaaagtcc cacacattgt ggacagatgg     3180

aatagaagag agtgatctga tcatacccaa gtctttagct gggccactca gccatcacaa     3240

taccagagag ggctacagga cccaaatgaa agggccatgg cacagtgaag agcttgaaat     3300

tcggtttgag gaatgcccag gcactaaggt ccacgtggag gaaacatgtg gaacaagagg     3360

accatctctg agatcaacca ctgcaagcgg aagggtgatc gaggaatggt gctgcaggga     3420

gtgcacaatg cccccactgt cgttccgggc taaagatggc tgttggtatg gaatggagat     3480

aaggcccagg aaagaaccag aaagcaactt agtaaggtca atggtgactg caggatcaac     3540

tgatcacatg gaccacttct cccttggagt gcttgtgatc ctgctcatgg tgcaggaagg     3600

gctgaagaag agaatgacca caaagatcat cataagcaca tcaatggcag tgctggtagc     3660

tatgatcctg ggaggatttt caatgagtga cctggctaag cttgcaattt tgatgggtgc     3720

caccttcgcg gaaatgaaca ctggaggaga tgtagctcat ctggcgctga tagcggcatt     3780

caaagtcaga ccagcgttgc tggtatcttt catcttcaga gctaattgga caccccgtga     3840

aagcatgctg ctggccttgg cctcgtgtct tttgcaaact gcgatctccg ccttggaagg     3900

cgacctgatg gttctcatca atggttttgc tttggcctgg ttggcaatac gagcgatggt     3960

tgttccacgc actgataaca tcaccttggc aatcctggct gctctgacac cactggcccg     4020

gggcacactg cttgtggcgt ggagagcagg ccttgctact tgcggggggt ttatgctcct     4080

ctctctgaag ggaaaaggca gtgtgaagaa gaacttacca tttgtcatgg ccctgggact     4140

aaccgctgtg aggctggtcg accccatcaa cgtggtggga ctgctgttac tcacaaggag     4200

tgggaagcgg agctggcccc ctagcgaagt actcacagct gttggcctga tatgcgcatt     4260

ggctggaggg ttcgccaagg cagatataga gatggctggg cccatggccg cggtcggtct     4320

gctaattgtc agttacgtgg tctcaggaaa gagtgtggac atgtacattg aaagagcagg     4380

tgacatcaca tgggaaaaag atgcggaagt cactggaaac agtccccggc tcgatgtggc     4440

gctagatgag agtggtgatt tctccctggt ggaggatgac ggtcccccca tgagagagat     4500

catactcaag gtggtcctga tgaccatctg tggcatgaat ccaatagcca taccctttgc     4560

agctggagcg tggtacgtat acgtgaagac tggaaaaagg agtggtgctc tatgggatgt     4620

gcctgctccc aaggaagtaa aaaaggggga gaccacagat ggagtgtaca gagtaatgac     4680

tcgtagactg ctaggttcaa cacaagttgg agtgggagtt atgcaagagg gggtctttca     4740

cactatgtgg cacgtcacaa aaggatccgc gctgagaagc ggtgaaggga gacttgatcc     4800

atactgggga gatgtcaagc aggatctggt gtcatactgt ggtccatgga agctagatgc     4860

cgcctgggac gggcacagcg aggtgcagct cttggccgtg ccccccggag agagagcgag     4920

gaacatccag actctgcccg gaatatttaa gacaaaggat ggggacattg gagcggttgc     4980

gctggattac ccagcaggaa cttcaggatc tccaatccta gacaagtgtg ggagagtgat     5040

aggactttat ggcaatgggg tcgtgatcaa aaatgggagt tatgttagtg ccatcaccca     5100

agggaggagg gaagaagaga ctcctgttga gtgcttcgag ccctcgatgc tgaagaagaa     5160

gcagctaact gtcttagact tgcatcctgg agctgggaaa accaggagag ttcttcctga     5220

aatagtccgt gaagccataa aaacaagact ccgtactgtg atcttagctc caaccagggt     5280

tgtcgctgct gaaatggagg aggcccttag agggcttcca gtgcgttata tgacaacagc     5340

agtcaatgtc acccactctg gaacagaaat cgtcgactta atgtgccatg ccaccttcac     5400

ttcacgtcta ctacagccaa tcagagtccc caactataat ctgtatatta tggatgaggc     5460

ccacttcaca gatccctcaa gtatagcagc aagaggatac atttcaacaa gggttgagat     5520

gggcgaggcg gctgccatct tcatgaccgc cacgccacca ggaacccgtg acgcatttcc     5580

ggactccaac tcaccaatta tggacaccga agtggaagtc ccagagagag cctggagctc     5640

aggctttgat tgggtgacgg atcattctgg aaaaacagtt tggtttgttc caagcgtgag     5700

gaacggcaat gagatcgcag cttgtctgac aaaggctgga aaacgggtca tacagctcag     5760

cagaaagact tttgagacag agttccagaa aacaaaacat caagagtggg actttgtcgt     5820

gacaactgac atttcagaga tgggcgccaa ctttaaagct gaccgtgtca tagattccag     5880

gagatgccta aagccggtca tacttgatgg cgagagagtc attctggctg gacccatgcc     5940

tgtcacacat gccagcgctg cccagaggag ggggcgcata ggcaggaatc ccaacaaacc     6000

tggagatgag tatctgtatg gaggtgggtg cgcagagact gacgaagacc atgcacactg     6060

gcttgaagca agaatgctcc ttgacaatat ttacctccaa gatggcctca tagcctcgct     6120

ctatcgacct gaggccgaca aagtagcagc cattgaggga gagttcaagc ttaggacgga     6180

gcaaaggaag acctttgtgg aactcatgaa aagaggagat cttcctgttt ggctggccta     6240

tcaggttgca tctgccggaa taacctacac agatagaaga tggtgctttg atggcacgac     6300

caacaacacc ataatggaag atagtgtgcc ggcagaggtg tggaccagac acggagagaa     6360

aagagtgctc aaaccgaggt ggatggacgc cagagtttgt tcagatcatg cggccctgaa     6420

gtcattcaag gagtttgccg ctgggaaaag aggagcggct tttggagtga tggaagccct     6480

gggaacactg ccaggacaca tgacagagag attccaggaa gccattgaca acctcgctgt     6540

gctcatgcgg gcagagactg gaagcaggcc ttacaaagcc gcggcggccc aattgccgga     6600

gaccctagag accataatgc ttttggggtt gctgggaaca gtctcgctgg gaatcttctt     6660

cgtcttgatg aggaacaagg gcatagggaa gatgggcttt ggaatggtga ctcttggggc     6720

cagcgcatgg ctcatgtggc tctcggaaat tgagccagcc agaattgcat gtgtcctcat     6780

tgttgtgttc ctattgctgg tggtgctcat acctgagcca gaaaagcaaa gatctcccca     6840

ggacaaccaa atggcaatca tcatcatggt agcagtaggt cttctgggct tgattaccgc     6900

caatgaactc ggatggttgg agagaacaaa gagtgaccta agccatctaa tgggaaggag     6960

agaggagggg gcaaccatag gattctcaat ggacattgac ctgcggccag cctcagcttg     7020

ggccatctat gctgccttga caactttcat taccccagcc gtccaacatg cagtgaccac     7080

ctcatacaac aactactcct taatggcgat ggccacgcaa gctggagtgt tgtttggtat     7140

gggcaaaggg atgccattct acgcatggga ctttggagtc ccgctgctaa tgataggttg     7200

ctactcacaa ttaacacccc tgaccctaat agtggccatc attttgctcg tggcgcacta     7260

catgtacttg atcccagggc tgcaggcagc agctgcgcgt gctgcccaga agagaacggc     7320

agctggcatc atgaagaacc ctgttgtgga tggaatagtg gtgactgaca ttgacacaat     7380

gacaattgac ccccaagtgg agaaaaagat gggacaggtg ctactcatag cagtagccgt     7440

ctccagcgcc atactgtcgc ggaccgcctg ggggtggggg gaggctgggg ccctgatcac     7500

agccgcaact tccactttgt gggaaggctc tccgaacaag tactggaact cctctacagc     7560

cacttcactg tgtaacattt ttaggggaag ttacttggct ggagcttctc taatctacac     7620

agtaacaaga aacgctggct tggtcaagag acgtgggggt ggaacaggag agaccctggg     7680

agagaaatgg aaggcccgct tgaaccagat gtcggccctg gagttctact cctacaaaaa     7740

gtcaggcatc accgaggtgt gcagagaaga ggcccgccgc gccctcaagg acggtgtggc     7800

aacgggaggc catgctgtgt cccgaggaag tgcaaagctg agatggttgg tggagcgggg     7860

atacctgcag ccctatggaa aggtcattga tcttggatgt ggcagagggg gctggagtta     7920

ctacgccgcc accatccgca aagttcaaga agtgaaagga tacacaaaag gaggccctgg     7980

tcatgaagaa cccgtgttgg tgcaaagcta tgggtggaac atagtccgtc ttaagagtgg     8040

ggtggacgtc tttcatatgg cggctgagcc gtgtgacacg ctgctgtgtg acataggtga     8100

gtcatcatct agtcctgaag tggaagaagc acggacgctc agagtcctct ccatggtggg     8160

ggattggctt gaaaaaagac caggagcctt ttgtataaaa gtgttgtgcc catacaccag     8220

cactatgatg gaaaccctgg agcgactgca gcgtaggtat gggggaggac tggtcagagt     8280

gccactctcc cgcaactcta cacatgagat gtactgggtc tctggagcga aaagcaacac     8340

cataaaaagt gtgtccacca cgagccagct cctcttgggg cgcatggacg ggcctaggag     8400

gccagtgaaa tatgaggagg atgtgaatct cggctctggc acgcgggctg tggtaagctg     8460

cgctgaagct cccaacatga agatcattgg taaccgcatt gaaaggatcc gcagtgagca     8520

cgcggaaacg tggttctttg acgagaacca cccatatagg acatgggctt accatggaag     8580

ctatgaggcc cccacacaag ggtcagcgtc ctctctaata aacggggttg tcaggctcct     8640

gtcaaaaccc tgggatgtgg tgactggagt cacaggaata gccatgaccg acaccacacc     8700

gtatggtcag caaagagttt tcaaggaaaa agtggacact agggtgccag acccccaaga     8760

aggcactcgt caggttatga gcatggtctc ttcctggttg tggaaagagc taggcaaaca     8820

caaacggcca cgagtctgta ccaaagaaga gttcatcaac aaggttcgta gcaatgcagc     8880

attaggggca atatttgaag aggaaaaaga gtggaagact gcagtggaag ctgtgaacga     8940

tccaaggttc tgggctctag tggacaagga aagagagcac cacctgagag gagagtgcca     9000

gagttgtgtg tataacatga tgggaaaaag agaaaagaaa caaggggaat ttggaaaggc     9060

caagggcagc cgcgccatct ggtatatgtg gctaggggct agatttctag agttcgaagc     9120

ccttggattc ttgaacgagg atcactggat ggggagagag aactcaggag gtggtgttga     9180

agggctggga ttacaaagac tcggatatgt cctagaagag atgagtcgta taccaggagg     9240

aaggatgtat gcagatgaca ctgctggctg ggacacccgc attagcaggt ttgatctgga     9300

gaatgaagct ctaatcacca accaaatgga gaaagggcac agggccttgg cattggccat     9360

aatcaagtac acataccaaa acaaagtggt aaaggtcctt agaccagctg aaaaagggaa     9420

aacagttatg gacattattt cgagacaaga ccaaaggggg agcggacaag ttgtcactta     9480

cgctcttaac acatttacca acctagtggt gcaactcatt cggaatatgg aggctgagga     9540

agttctagag atgcaagact tgtggctgct gcggaggtca gagaaagtga ccaactggtt     9600

gcagagcaac ggatgggata ggctcaaacg aatggcagtc agtggagatg attgcgttgt     9660

gaagccaatt gatgataggt ttgcacatgc cctcaggttc ttgaatgata tgggaaaagt     9720

tagaaaggac acacaagagt ggaaaccctc aactggatgg gacaactggg aagaagttcc     9780

gttttgctcc caccacttca acaagctcca tctcaaggac gggaggtcca ttgtggttcc     9840

ctgccgccac caagatgaac tgattggccg ggcccgcgtc tctccagggg cgggatggag     9900

catccgggag actgcttgcc tagcaaaatc atatgcgcag atgtggcagc tcctttattt     9960

ccacagaagg gacctccgac tgatggccaa tgccatttgt tcatctgtgc cagttgactg    10020

ggttccaact gggagaacta cctggtcaat ccatggaaag ggagaatgga tgaccactga    10080

agacatgctt gtggtgtgga acagagtgtg gattgaggag aacgaccaca tggaagacaa    10140

gaccccagtt acgaaatgga cagacattcc ctatttggga aaaagggaag acttgtggtg    10200

tggatctctc atagggcaca gaccgcgcac cacctgggct gagaacatta aaaacacagt    10260

caacatggtg cgcaggatca taggtgatga agaaaagtac atggactacc tatccaccca    10320

agttcgctac ttgggtgaag aagggtctac acctggagtg ctgtaagcac caatcttaat    10380

gttgtcaggc ctgctagtca gccacagctt ggggaaagct gtgcagcctg tgacccccca    10440

ggagaagctg ggaaaccaag cctatagtca ggccgagaac gccatggcac ggaagaagcc    10500

atgctgcctg tgagcccctc agaggatact gagtcaaaaa accccacgcg cttggaggcg    10560

caggatggga aaagaaggtg gcgaccttcc ccacccttca atctggggcc tgaactggag    10620

atcagctgtg gatccccaga agagggacta gtggttagag gagacccccc ggaaaacgca    10680

aaacagcata ttgacgctgg gaaagaccag agactccatg agtttcc                  10727


<210>  13
<211>  10374
<212>  DNA
<213>  Zika virus isolate Z1106033 polyprotein gene

<400>  13
acaggtttta ttttggattt ggaaacgaga gtttctggtc atgaaaaacc caaaaaagaa       60

atccggagga ttccggattg tcaatatgct aaaacgcgga gtagcccgtg tgagcccctt      120

tgggggcttg aagaggctgc cagccggact tctgctgggt catgggccca tcaggatggt      180

cttggcgatt ctagcctttt tgagattcac ggcaatcaag ccatcactgg gtctcatcaa      240

tagatggggt tcagtgggga aaaaagaggc tatggaaata ataaagaagt tcaagaaaga      300

tctggctgcc atgctgagaa taatcaatgc taggaaggag aagaagagac gaggcgcaga      360

tactagtgtc ggaattgttg gcctcctgct gaccacagct atggcagcgg aggtcactag      420

acgtgggagt gcatactata tgtacttgga cagaaacgat gctggggagg ccatatcttt      480

tccaaccaca ttggggatga ataagtgtta tatacagatc atggatcttg gacacacgtg      540

tgatgccacc atgagctatg aatgccctat gctggatgag ggggtggaac cagatgacgt      600

cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac ggaacctgcc atcacaaaaa      660

aggtgaagca cggagatcta gaagagctgt gacgctcccc tcccattcca ctaggaagct      720

gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac acaaagcact tgattagagt      780

cgaaaattgg atattcagga accctggctt cgcgttagca gcagctgcca tcgcttggct      840

tttgggaagc tcaacgagcc aaaaagtcat atacttggtc atgatactgc tgattgcccc      900

ggcatacagc atcaggtgca taggagtcag caatagggac tttgtggaag gtatgtcagg      960

tgggacttgg gttgatgttg tcttggaaca tggaggttgt gtcactgtaa tggcacagga     1020

caaaccgact gtcgacatag agctggttac aacaacagtc agcaacatgg cggaggtaag     1080

atcctactgc tatgaggcat caatatcaga catggcttcg gacagccgct gcccaacaca     1140

aggtgaagcc taccttgaca agcaatcaga cactcaatat gtctgcaaaa gaacgttagt     1200

ggacagaggc tggggaaatg gatgtggact ttttggcaaa gggagcctgg tgacatgcgc     1260

taagtttgca tgctccaaga aaatgaccgg gaagagcatc cagccagaga atctggagta     1320

ccggataatg ctgtcagttc atggctccca gcacagtggg atgatcgtta atgacacagg     1380

acatgaaact gatgagaata gagcgaaagt tgagataacg cccaattcac caagagccga     1440

agccaccctg ggggggtttg gaagcctagg acttgattgt gaaccgagga caggccttga     1500

cttttcagat ttgtattact tgactatgaa taacaagcac tggctggttc acaaggagtg     1560

gttccacgac attccattac cttggcacgc tggggcagac accggaactc cacactggaa     1620

caacaaagaa gcactggtag agttcaagga cgcacatgcc aaaaggcaaa ctgtcgtggt     1680

tctagggagt caagaaggag cagttcacac ggcccttgct ggagctctgg aggctgagat     1740

ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa tgtcgcctga aaatggataa     1800

acttagattg aagggcgtgt catactcctt gtgtactgca gcgttcacat tcaccaagat     1860

cccggctgaa acactgcacg ggacagtcac agtggaggta cagtacgcag ggacagatgg     1920

accttgcaag gttccagctc agatggcggt ggacatgcaa actctgaccc cagttgggag     1980

gttgataacc gctaaccccg taatcactga aagcactgag aactctaaga tgatgctgga     2040

acttgatcca ccatttgggg actcttacat tgtcatagga gtcggggaga agaagatcac     2100

ccaccactgg cacaggagtg gcagcaccat tggaaaagca tttgaagcca ctgtgagagg     2160

tgccaagaga atggcagtct tgggagacac agcctgggac tttggatcag ttggaggcgc     2220

tctcaactca ttgggcaagg gcatccatca aatctttgga gcagctttca aatcattgtt     2280

tggaggaatg tcctggttct cacaaattct cattggaacg ttgctgatgt ggttgggtct     2340

gaacgcaaag aatggatcta tttcccttat gtgcttggcc ttagggggag tgttgatctt     2400

cttatccaca gccgtctctg ctgatgtggg gtgctcggtg gacttctcaa agaaggagac     2460

gagatgcggt acaggggtgt tcgtctataa cgacgttgaa gcctggaggg acaggtacaa     2520

gtaccatcct gactcccccc gtagattggc agcagcagtc aagcaagcct gggaagatgg     2580

tatctgcggg atctcctctg tttcaagaat ggaaaacatc atgtggagat cagtagaagg     2640

ggagctcaac gcaatcctgg aagagaatgg agttcaactg acggtcgttg tgggatctgt     2700

aaaaaacccc atgtggagag gtccacagag attgcccgtg cctgtgaacg agctgcccca     2760

cggctggaag gcttggggga aatcgtactt cgtcagagca gcaaagacaa ataacagctt     2820

tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa catagagcat ggaacagctt     2880

tcttgtggag gatcatgggt tcggggtatt tcacactagt gtctggctca aggttagaga     2940

agattattca ttagagtgtg atccagccgt tattggaaca gctgttaagg gaaaggaggc     3000

tgtacacagt gatctaggct actggattga gagtgagaag aatgacacat ggaggctgaa     3060

gagggcccat ctgatcgaga tgaaaacatg tgaatggcca aagtcccaca cattgtggac     3120

agatggaata gaagagagtg atctgatcat acccaagtct ttagctgggc cactcagcca     3180

tcacaatacc agagagggct acaggaccca aatgaaaggg ccatggcaca gtgaagagct     3240

tgaaattcgg tttgaggaat gcccaggcac taaggtccac gtggaggaaa catgtggaac     3300

gagaggacca tctctgagat caaccactgc aagcggaagg gtgatcgagg aatggtgctg     3360

cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa gatggctgtt ggtatggaat     3420

ggagataagg cccaggaaag aaccagaaag caacttagta aggtcaatgg tgactgcagg     3480

atcaactgat cacatggacc acttctccct tggagtgctt gtgattctgc tcatggtgca     3540

ggaagggttg aagaagagaa tgaccacaaa gatcatcata agcacatcaa tggcagtgct     3600

ggtagctatg atcctgggag gattttcaat gagtgacctg gctaagcttg caattttgat     3660

gggtgccacc ttcgcggaaa tgaacactgg aggagatgta gctcatctgg cgctgatagc     3720

ggcattcaaa gtcagaccag cgttgctggt atctttcatc ttcagagcta attggacacc     3780

ccgtgaaagc atgctgctgg ccttggcctc gtgtcttttg caaactgcga tctccgcctt     3840

ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg gcctggttgg caatacgagc     3900

gatggttgtt ccacgcactg ataacatcac cttggcaatc ctggctgctc tgacaccact     3960

ggcccggggc acactgcttg tggcgtggag agcaggcctt gctacttgcg gggggtttat     4020

gctcctctct ctgaagggaa aaggcagtgt gaagaagaac ttaccatttg tcatggccct     4080

gggactaacc gctgtgaggc tggtcgaccc catcaacgtg gtgggactgc tgttgctcac     4140

aaggagtggg aagcggagct ggccccctag cgaagtactc acagctgttg gcctgatatg     4200

cgcattggct ggagggttcg ccaaggcaga tatagagatg gctgggccca tggccgcggt     4260

cggtctgcta attgtcagtt acgtggtctc aggaaagagt gtggacatgt acattgaaag     4320

agcaggtgac atcacatggg aaaaagatgc ggaagtcact ggaaacagtc cccggctcga     4380

tgtggcgcta gatgagagtg gtgatttctc cctggtggag gatgacggtc cccccatgag     4440

agagatcata ctcaaggtgg tcctgatgac catctgtggc atgaacccaa tagccatacc     4500

ctttgcagct ggagcgtggt acgtatacgt gaagactgga aaaaggagtg gtgctctatg     4560

ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc acagatggag tgtacagagt     4620

aatgactcgt agactgctag gttcaacaca agttggagtg ggagttatgc aagagggggt     4680

ctttcacact atgtggcacg tcacaaaagg atccgcgctg agaagcggtg aagggagact     4740

tgatccatac tggggagatg tcaagcagga tctggtgtca tactgtggtc catggaagct     4800

agatgccgcc tgggacgggc acagcgaggt gcagctcttg gccgtgcccc ccggagagag     4860

agcgaggaac atccagactc tgcccggaat atttaagaca aaggatgggg acattggagc     4920

ggttgcgctg gattacccag caggaacttc aggatctcct atcctagaca agtgtgggag     4980

agtgatagga ctttatggca atggggtcgt gatcaaaaat gggagttatg ttagtgccat     5040

cacccaaggg aggagggagg aagagactcc tgttgagtgc ttcgagcctt cgatgctgaa     5100

gaagaagcag ctaactgtct tagacttgca tcctggagct gggaaaacca ggagagttct     5160

tcctgaaata gtccgtgaag ccataaaaac aagactccgt actgtgatct tagctccaac     5220

cagggttgtc gctgctgaaa tggaggaggc ccttagaggg cttccagtgc gttatatgac     5280

aacagcagtc aatgtcaccc actctggaac agaaatcgtc gacttaatgt gccatgccac     5340

cttcacttcg cgtctactac agccaatcag agtccccaac tataatctgt atattatgga     5400

tgaggcccac ttcacagatc cctcaagtat agcagcaaga ggatacattt caacaagggt     5460

tgagatgggc gaggcggccg ccatcttcat gaccgccacg ccaccaggaa cccgtgacgc     5520

atttccggac tccaactcac caattatgga caccgaagtg gaagtcccag agagagcctg     5580

gagctcaggc tttgattggg tgacggatca ttctggaaaa acagtttggt ttgttccaag     5640

cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag gctggaaaac gggtcataca     5700

gctcagcaga aagacttttg agacagagtt ccagaaaaca aaacatcaag agtgggactt     5760

tgtcgtgaca actgacattt cagagatggg cgccaacttt aaagctgacc gtgtcataga     5820

ttccaggaga tgcctaaagc cggtcatact tgatggcgag agagtcattc tggctggacc     5880

catgcctgtc acacatgcca gcgctgccca gaggaggggg cgcataggca ggaatcccaa     5940

caaacctgga gatgagtatc tgtatggagg tgggtgcgca gagactgacg aagaccatgc     6000

acactggctt gaagcaagaa tgctccttga caatatttac ctccaagatg gcctcatagc     6060

ctcgctctat cgacctgagg ccgacaaagt agcagccatt gagggagagt tcaagcttag     6120

gacggagcaa aggaagacct ttgtggaact catgaaaaga ggagatcttc ctgtttggct     6180

ggcctatcag gttgcatctg ccggaataac ctacacagat agaagatggt gctttgatgg     6240

cacgaccaac aacaccataa tggaagacag tgtgccggca gaagtgtgga ccagacacgg     6300

agagaaaaga gtgctcaaac cgaggtggat ggacgccaga gtttgttcag atcatgcggc     6360

cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga gcggcttttg gagtgatgga     6420

agccctggga acactgccag gacacatgac agagagattc caggaagcca ttgacaacct     6480

cgctgtgctc atgcgggcag agactggaag caggccttac aaagccgcgg cggcccaatt     6540

gccggagacc ctagagacca ttatgctttt ggggttgctg ggaacagtct cgctgggaat     6600

cttcttcgtc ttgatgagga acaagggcat agggaagatg ggctttggaa tggtgactct     6660

tggggccagc gcatggctca tgtggctctc ggaaattgag ccagccagaa ttgcatgtgt     6720

cctcattgtt gtgttcctat tgctggtggt gctcatacct gagccagaaa agcaaagatc     6780

tccccaggac aaccaaatgg caatcatcat catggtagca gtaggtcttc tgggcttgat     6840

taccgccaat gaactcggat ggttggagag aacaaagagt gacctaagcc atctaatggg     6900

aaggagagag gagggggcaa ccataggatt ctcaatggac attgacctgc ggccagcctc     6960

agcttgggcc atctatgctg ccttgacaac tttcattacc ccagccgtcc aacatgcagt     7020

gaccacctca tacaacaact actccttaat ggcgatggcc acgcaagctg gagtgttgtt     7080

tggtatgggc aaagggatgc cattctacgc atgggacttt ggagtcccgc tgctaatgat     7140

aggttgctac tcacaattaa cacccctgac cctaatagtg gccatcattt tgctcgtggc     7200

gcactacatg tacttgatcc cagggctgca ggcagcagct gcgcgtgctg cccagaagag     7260

aacggcagct ggcatcatga agaaccctgt tgtggatgga atagtggtga ctgacattga     7320

cacaatgaca attgaccccc aagtggagaa aaagatggga caggtgctac tcatagcagt     7380

agccgtctcc agcgccatac tgtcgcggac cgcctggggg tggggggagg ctggggccct     7440

gatcacagcc gcaacttcca ctttgtggga aggctctccg aacaagtact ggaactcctc     7500

tacagccact tcactgtgta acatttttag gggaagttac ttggctggag cttctctaat     7560

ctacacagta acaagaaacg ctggcttggt caagagacgt gggggtggaa caggagagac     7620

cctgggagag aaatggaagg cccgcttgaa ccagatgtcg gccctggagt tctactccta     7680

caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc cgccgcgccc tcaaggacgg     7740

tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca aagctgagat ggttggtgga     7800

gcggggatac ctgcagccct atggaaaggt cattgatctt ggatgtggca gagggggctg     7860

gagttactac gccgccacca tccgcaaagt tcaagaagtg aaaggataca caaaaggagg     7920

ccctggtcat gaagaacccg tgttggtgca aagctatggg tggaacatag tccgtcttaa     7980

gagtggggtg gacgtctttc atatggcggc tgagccgtgt gacacgttgc tgtgtgacat     8040

aggtgagtca tcatctagtc ctgaagtgga agaagcacgg acgctcagag tcctctccat     8100

ggtgggggat tggcttgaaa aaagaccagg agccttttgt ataaaagtgt tgtgcccata     8160

caccagcact atgatggaaa ccctggagcg actgcagcgt aggtatgggg gaggactggt     8220

cagagtgcca ctctcccgca actctacaca tgagatgtac tgggtctctg gagcgaaaag     8280

caacaccata aaaagtgtgt ccaccacgag ccagctcctc ttggggcgca tggacgggcc     8340

taggaggcca gtgaaatatg aggaggatgt gaatctcggc tctggcacgc gggctgtggt     8400

aagctgcgct gaagctccca acatgaagat cattggtaac cgcattgaaa ggatccgcag     8460

tgagcacgcg gaaacgtggt tctttgacga gaaccaccca tataggacat gggcttacca     8520

tggaagctat gaggccccca cacaagggtc agcgtcctct ctaataaacg gggttgtcag     8580

gctcctgtca aaaccctggg atgtggtgac tggagtcaca ggaatagcca tgaccgacac     8640

cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg gacactaggg tgccagaccc     8700

ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc tggttgtgga aagagctagg     8760

caaacacaaa cggccacgag tctgtaccaa agaagagttc atcaacaagg ttcgtagcaa     8820

tgcagcatta ggggcaatat ttgaagagga aaaagagtgg aagactgcag tggaagctgt     8880

gaacgatcca aggttctggg ctctagtgga caaggaaaga gagcaccacc tgagaggaga     8940

gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa aagaaacaag gggaatttgg     9000

aaaggccaag ggcagccgcg ccatctggta tatgtggcta ggggctagat ttctagagtt     9060

cgaagccctt ggattcttga acgaggatca ctggatgggg agagagaact caggaggtgg     9120

tgttgaaggg ctgggattac aaagactcgg atatgtccta gaagagatga gtcgtatacc     9180

aggaggaagg atgtatgcag atgacactgc tggctgggac acccgcatta gcaggtttga     9240

tctggagaat gaagctctaa tcaccaacca aatggagaaa gggcacaggg ccttggcatt     9300

ggccataatc aagtacacat accaaaacaa agtggtaaag gtccttagac cagctgaaaa     9360

agggaaaaca gttatggaca ttatttcgag acaagaccaa agggggagcg gacaagttgt     9420

cacttacgct cttaacacat ttaccaacct agtggtgcaa ctcattcgga atatggaggc     9480

tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg aggtcagaga aagtgactaa     9540

ctggttgcag agcaacggat gggataggct caaacgaatg gcagtcagtg gagatgattg     9600

cgttgtgaag ccaattgatg ataggtttgc acatgccctc aggttcttga atgatatggg     9660

aaaagttagg aaggacacac aagagtggaa accctcaact ggatgggaca actgggaaga     9720

agttccgttt tgctcccacc acttcaacaa gctccatctc aaggacggga ggtccattgt     9780

ggttccctgc cgccaccaag atgaactgat tggccgggcc cgcgtctctc caggggcggg     9840

atggagcatc cgggagactg cttgcctagc aaaatcatat gcgcaaatgt ggcagctcct     9900

ttatttccac agaagggacc tccgactgat ggccaatgcc atttgttcat ctgtgccagt     9960

tgactgggtt ccaactggga gaactacctg gtcaatccat ggaaagggag aatggatgac    10020

cactgaagac atgcttgtgg tgtggaacag agtgtggatt gaggagaacg accacatgga    10080

agacaagacc ccagttacga aatggacaga cattccctat ttgggaaaaa gggaagactt    10140

gtggtgtgga tctctcatag ggcacagacc gcgcaccacc tgggctgaga acattaaaaa    10200

cacagtcaac atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actacctatc    10260

cacccaagtt cgctacttgg gtgaagaagg gtctacacct ggagtgctgt aagcaccaat    10320

cttaatgttg tcaggcctgc tagtcagcca cagcttgggg aaagctgtgc agcc          10374


<210>  14
<211>  3423
<212>  PRT
<213>  Zika virus strain BeH818995 polyprotein

<400>  14

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asp 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  15
<211>  3423
<212>  PRT
<213>  Zika virus isolate SSABR1 polyprotein

<400>  15

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  16
<211>  3423
<212>  PRT
<213>  Zika virus strain Natal RGN polyprotein

<400>  16

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Ala Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Val 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Ile Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  17
<211>  3423
<212>  PRT
<213>  Zika virus strain Haiti/1225/2014 polyprotein

<400>  17

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser His Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp Tyr Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Met  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  18
<211>  3423
<212>  PRT
<213>  Zika virus strain PRVABC59 polyprotein

<400>  18

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Thr 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Val Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  19
<211>  3423
<212>  PRT
<213>  Zika virus strain: MR766-NIID polyprotein

<400>  19

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val Tyr  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Val Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Pro Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Ile Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Val Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Gly  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Leu  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Leu  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Ile Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Arg 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Thr Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu Tyr Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  20
<211>  3419
<212>  PRT
<213>  Zika virus NC_012532.1 polyprotein

<400>  20

Met Lys Asn Pro Lys Glu Glu Ile Arg Arg Ile Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu 
        435                 440                 445             


Asp Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala 
    450                 455                 460                 


Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr 
465                 470                 475                 480 


Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His 
                485                 490                 495     


Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His 
            500                 505                 510         


Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu 
        515                 520                 525             


Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu 
    530                 535                 540                 


Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu 
545                 550                 555                 560 


Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys 
                565                 570                 575     


Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser 
            580                 585                 590         


Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu 
        595                 600                 605             


His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro 
    610                 615                 620                 


Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro 
625                 630                 635                 640 


Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu 
                645                 650                 655     


Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr 
            660                 665                 670         


Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg 
        675                 680                 685             


Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala 
    690                 695                 700                 


Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val 
705                 710                 715                 720 


Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly 
                725                 730                 735     


Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile 
            740                 745                 750         


Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly 
        755                 760                 765             


Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu 
    770                 775                 780                 


Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe Ser Lys 
785                 790                 795                 800 


Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr Asn Asp Val Glu 
                805                 810                 815     


Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu 
            820                 825                 830         


Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser 
        835                 840                 845             


Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu 
    850                 855                 860                 


Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val Val Val 
865                 870                 875                 880 


Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val 
                885                 890                 895     


Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr 
            900                 905                 910         


Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp 
        915                 920                 925             


Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp Asn Ser Phe Leu 
    930                 935                 940                 


Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp Leu Lys 
945                 950                 955                 960 


Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr 
                965                 970                 975     


Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile 
            980                 985                 990         


Glu Ser Glu Lys Asn Asp Thr Trp  Arg Leu Lys Arg Ala  His Leu Ile 
        995                 1000                 1005             


Glu Met  Lys Thr Cys Glu Trp  Pro Lys Ser His Thr  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Val Glu Glu Ser Asp  Leu Ile Ile Pro Lys  Ser Leu Ala 
    1025                 1030                 1035             


Gly Pro  Leu Ser His His Asn  Thr Arg Glu Gly Tyr  Arg Thr Gln 
    1040                 1045                 1050             


Val Lys  Gly Pro Trp His Ser  Glu Glu Leu Glu Ile  Arg Phe Glu 
    1055                 1060                 1065             


Glu Cys  Pro Gly Thr Lys Val  Tyr Val Glu Glu Thr  Cys Gly Thr 
    1070                 1075                 1080             


Arg Gly  Pro Ser Leu Arg Ser  Thr Thr Ala Ser Gly  Arg Val Ile 
    1085                 1090                 1095             


Glu Glu  Trp Cys Cys Arg Glu  Cys Thr Met Pro Pro  Leu Ser Phe 
    1100                 1105                 1110             


Arg Ala  Lys Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Arg 
    1115                 1120                 1125             


Lys Glu  Pro Glu Ser Asn Leu  Val Arg Ser Met Val  Thr Ala Gly 
    1130                 1135                 1140             


Ser Thr  Asp His Met Asp His  Phe Ser Leu Gly Val  Leu Val Ile 
    1145                 1150                 1155             


Leu Leu  Met Val Gln Glu Gly  Leu Lys Lys Arg Met  Thr Thr Lys 
    1160                 1165                 1170             


Ile Ile  Met Ser Thr Ser Met  Ala Val Leu Val Val  Met Ile Leu 
    1175                 1180                 1185             


Gly Gly  Phe Ser Met Ser Asp  Leu Ala Lys Leu Val  Ile Leu Met 
    1190                 1195                 1200             


Gly Ala  Thr Phe Ala Glu Met  Asn Thr Gly Gly Asp  Val Ala His 
    1205                 1210                 1215             


Leu Ala  Leu Val Ala Ala Phe  Lys Val Arg Pro Ala  Leu Leu Val 
    1220                 1225                 1230             


Ser Phe  Ile Phe Arg Ala Asn  Trp Thr Pro Arg Glu  Ser Met Leu 
    1235                 1240                 1245             


Leu Ala  Leu Ala Ser Cys Leu  Leu Gln Thr Ala Ile  Ser Ala Leu 
    1250                 1255                 1260             


Glu Gly  Asp Leu Met Val Leu  Ile Asn Gly Phe Ala  Leu Ala Trp 
    1265                 1270                 1275             


Leu Ala  Ile Arg Ala Met Ala  Val Pro Arg Thr Asp  Asn Ile Ala 
    1280                 1285                 1290             


Leu Pro  Ile Leu Ala Ala Leu  Thr Pro Leu Ala Arg  Gly Thr Leu 
    1295                 1300                 1305             


Leu Val  Ala Trp Arg Ala Gly  Leu Ala Thr Cys Gly  Gly Ile Met 
    1310                 1315                 1320             


Leu Leu  Ser Leu Lys Gly Lys  Gly Ser Val Lys Lys  Asn Leu Pro 
    1325                 1330                 1335             


Phe Val  Met Ala Leu Gly Leu  Thr Ala Val Arg Val  Val Asp Pro 
    1340                 1345                 1350             


Ile Asn  Val Val Gly Leu Leu  Leu Leu Thr Arg Ser  Gly Lys Arg 
    1355                 1360                 1365             


Ser Trp  Pro Pro Ser Glu Val  Leu Thr Ala Val Gly  Leu Ile Cys 
    1370                 1375                 1380             


Ala Leu  Ala Gly Gly Phe Ala  Lys Ala Asp Ile Glu  Met Ala Gly 
    1385                 1390                 1395             


Pro Met  Ala Ala Val Gly Leu  Leu Ile Val Ser Tyr  Val Val Ser 
    1400                 1405                 1410             


Gly Lys  Ser Val Asp Met Tyr  Ile Glu Arg Ala Gly  Asp Ile Thr 
    1415                 1420                 1425             


Trp Glu  Lys Asp Ala Glu Val  Thr Gly Asn Ser Pro  Arg Leu Asp 
    1430                 1435                 1440             


Val Ala  Leu Asp Glu Ser Gly  Asp Phe Ser Leu Val  Glu Glu Asp 
    1445                 1450                 1455             


Gly Pro  Pro Met Arg Glu Ile  Ile Leu Lys Val Val  Leu Met Ala 
    1460                 1465                 1470             


Ile Cys  Gly Met Asn Pro Ile  Ala Ile Pro Phe Ala  Ala Gly Ala 
    1475                 1480                 1485             


Trp Tyr  Val Tyr Val Lys Thr  Gly Lys Arg Ser Gly  Ala Leu Trp 
    1490                 1495                 1500             


Asp Val  Pro Ala Pro Lys Glu  Val Lys Lys Gly Glu  Thr Thr Asp 
    1505                 1510                 1515             


Gly Val  Tyr Arg Val Met Thr  Arg Arg Leu Leu Gly  Ser Thr Gln 
    1520                 1525                 1530             


Val Gly  Val Gly Val Met Gln  Glu Gly Val Phe His  Thr Met Trp 
    1535                 1540                 1545             


His Val  Thr Lys Gly Ala Ala  Leu Arg Ser Gly Glu  Gly Arg Leu 
    1550                 1555                 1560             


Asp Pro  Tyr Trp Gly Asp Val  Lys Gln Asp Leu Val  Ser Tyr Cys 
    1565                 1570                 1575             


Gly Pro  Trp Lys Leu Asp Ala  Ala Trp Asp Gly Leu  Ser Glu Val 
    1580                 1585                 1590             


Gln Leu  Leu Ala Val Pro Pro  Gly Glu Arg Ala Arg  Asn Ile Gln 
    1595                 1600                 1605             


Thr Leu  Pro Gly Ile Phe Lys  Thr Lys Asp Gly Asp  Ile Gly Ala 
    1610                 1615                 1620             


Val Ala  Leu Asp Tyr Pro Ala  Gly Thr Ser Gly Ser  Pro Ile Leu 
    1625                 1630                 1635             


Asp Lys  Cys Gly Arg Val Ile  Gly Leu Tyr Gly Asn  Gly Val Val 
    1640                 1645                 1650             


Ile Lys  Asn Gly Ser Tyr Val  Ser Ala Ile Thr Gln  Gly Lys Arg 
    1655                 1660                 1665             


Glu Glu  Glu Thr Pro Val Glu  Cys Phe Glu Pro Ser  Met Leu Lys 
    1670                 1675                 1680             


Lys Lys  Gln Leu Thr Val Leu  Asp Leu His Pro Gly  Ala Gly Lys 
    1685                 1690                 1695             


Thr Arg  Arg Val Leu Pro Glu  Ile Val Arg Glu Ala  Ile Lys Lys 
    1700                 1705                 1710             


Arg Leu  Arg Thr Val Ile Leu  Ala Pro Thr Arg Val  Val Ala Ala 
    1715                 1720                 1725             


Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro Val Arg  Tyr Met Thr 
    1730                 1735                 1740             


Thr Ala  Val Asn Val Thr His  Ser Gly Thr Glu Ile  Val Asp Leu 
    1745                 1750                 1755             


Met Cys  His Ala Thr Phe Thr  Ser Arg Leu Leu Gln  Pro Ile Arg 
    1760                 1765                 1770             


Val Pro  Asn Tyr Asn Leu Asn  Ile Met Asp Glu Ala  His Phe Thr 
    1775                 1780                 1785             


Asp Pro  Ser Ser Ile Ala Ala  Arg Gly Tyr Ile Ser  Thr Arg Val 
    1790                 1795                 1800             


Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met Thr Ala  Thr Pro Pro 
    1805                 1810                 1815             


Gly Thr  Arg Asp Ala Phe Pro  Asp Ser Asn Ser Pro  Ile Met Asp 
    1820                 1825                 1830             


Thr Glu  Val Glu Val Pro Glu  Arg Ala Trp Ser Ser  Gly Phe Asp 
    1835                 1840                 1845             


Trp Val  Thr Asp His Ser Gly  Lys Thr Val Trp Phe  Val Pro Ser 
    1850                 1855                 1860             


Val Arg  Asn Gly Asn Glu Ile  Ala Ala Cys Leu Thr  Lys Ala Gly 
    1865                 1870                 1875             


Lys Arg  Val Ile Gln Leu Ser  Arg Lys Thr Phe Glu  Thr Glu Phe 
    1880                 1885                 1890             


Gln Lys  Thr Lys Asn Gln Glu  Trp Asp Phe Val Ile  Thr Thr Asp 
    1895                 1900                 1905             


Ile Ser  Glu Met Gly Ala Asn  Phe Lys Ala Asp Arg  Val Ile Asp 
    1910                 1915                 1920             


Ser Arg  Arg Cys Leu Lys Pro  Val Ile Leu Asp Gly  Glu Arg Val 
    1925                 1930                 1935             


Ile Leu  Ala Gly Pro Met Pro  Val Thr His Ala Ser  Ala Ala Gln 
    1940                 1945                 1950             


Arg Arg  Gly Arg Ile Gly Arg  Asn Pro Asn Lys Pro  Gly Asp Glu 
    1955                 1960                 1965             


Tyr Met  Tyr Gly Gly Gly Cys  Ala Glu Thr Asp Glu  Gly His Ala 
    1970                 1975                 1980             


His Trp  Leu Glu Ala Arg Met  Leu Leu Asp Asn Ile  Tyr Leu Gln 
    1985                 1990                 1995             


Asp Gly  Leu Ile Ala Ser Leu  Tyr Arg Pro Glu Ala  Asp Lys Val 
    2000                 2005                 2010             


Ala Ala  Ile Glu Gly Glu Phe  Lys Leu Arg Thr Glu  Gln Arg Lys 
    2015                 2020                 2025             


Thr Phe  Val Glu Leu Met Lys  Arg Gly Asp Leu Pro  Val Trp Leu 
    2030                 2035                 2040             


Ala Tyr  Gln Val Ala Ser Ala  Gly Ile Thr Tyr Thr  Asp Arg Arg 
    2045                 2050                 2055             


Trp Cys  Phe Asp Gly Thr Thr  Asn Asn Thr Ile Met  Glu Asp Ser 
    2060                 2065                 2070             


Val Pro  Ala Glu Val Trp Thr  Lys Tyr Gly Glu Lys  Arg Val Leu 
    2075                 2080                 2085             


Lys Pro  Arg Trp Met Asp Ala  Arg Val Cys Ser Asp  His Ala Ala 
    2090                 2095                 2100             


Leu Lys  Ser Phe Lys Glu Phe  Ala Ala Gly Lys Arg  Gly Ala Ala 
    2105                 2110                 2115             


Leu Gly  Val Met Glu Ala Leu  Gly Thr Leu Pro Gly  His Met Thr 
    2120                 2125                 2130             


Glu Arg  Phe Gln Glu Ala Ile  Asp Asn Leu Ala Val  Leu Met Arg 
    2135                 2140                 2145             


Ala Glu  Thr Gly Ser Arg Pro  Tyr Lys Ala Ala Ala  Ala Gln Leu 
    2150                 2155                 2160             


Pro Glu  Thr Leu Glu Thr Ile  Met Leu Leu Gly Leu  Leu Gly Thr 
    2165                 2170                 2175             


Val Ser  Leu Gly Ile Phe Phe  Val Leu Met Arg Asn  Lys Gly Ile 
    2180                 2185                 2190             


Gly Lys  Met Gly Phe Gly Met  Val Thr Leu Gly Ala  Ser Ala Trp 
    2195                 2200                 2205             


Leu Met  Trp Leu Ser Glu Ile  Glu Pro Ala Arg Ile  Ala Cys Val 
    2210                 2215                 2220             


Leu Ile  Val Val Phe Leu Leu  Leu Val Val Leu Ile  Pro Glu Pro 
    2225                 2230                 2235             


Glu Lys  Gln Arg Ser Pro Gln  Asp Asn Gln Met Ala  Ile Ile Ile 
    2240                 2245                 2250             


Met Val  Ala Val Gly Leu Leu  Gly Leu Ile Thr Ala  Asn Glu Leu 
    2255                 2260                 2265             


Gly Trp  Leu Glu Arg Thr Lys  Asn Asp Ile Ala His  Leu Met Gly 
    2270                 2275                 2280             


Arg Arg  Glu Glu Gly Ala Thr  Met Gly Phe Ser Met  Asp Ile Asp 
    2285                 2290                 2295             


Leu Arg  Pro Ala Ser Ala Trp  Ala Ile Tyr Ala Ala  Leu Thr Thr 
    2300                 2305                 2310             


Leu Ile  Thr Pro Ala Val Gln  His Ala Val Thr Thr  Ser Tyr Asn 
    2315                 2320                 2325             


Asn Tyr  Ser Leu Met Ala Met  Ala Thr Gln Ala Gly  Val Leu Phe 
    2330                 2335                 2340             


Gly Met  Gly Lys Gly Met Pro  Phe Met His Gly Asp  Leu Gly Val 
    2345                 2350                 2355             


Pro Leu  Leu Met Met Gly Cys  Tyr Ser Gln Leu Thr  Pro Leu Thr 
    2360                 2365                 2370             


Leu Ile  Val Ala Ile Ile Leu  Leu Val Ala His Tyr  Met Tyr Leu 
    2375                 2380                 2385             


Ile Pro  Gly Leu Gln Ala Ala  Ala Ala Arg Ala Ala  Gln Lys Arg 
    2390                 2395                 2400             


Thr Ala  Ala Gly Ile Met Lys  Asn Pro Val Val Asp  Gly Ile Val 
    2405                 2410                 2415             


Val Thr  Asp Ile Asp Thr Met  Thr Ile Asp Pro Gln  Val Glu Lys 
    2420                 2425                 2430             


Lys Met  Gly Gln Val Leu Leu  Ile Ala Val Ala Ile  Ser Ser Ala 
    2435                 2440                 2445             


Val Leu  Leu Arg Thr Ala Trp  Gly Trp Gly Glu Ala  Gly Ala Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Thr Ser Thr  Leu Trp Glu Gly Ser  Pro Asn Lys 
    2465                 2470                 2475             


Tyr Trp  Asn Ser Ser Thr Ala  Thr Ser Leu Cys Asn  Ile Phe Arg 
    2480                 2485                 2490             


Gly Ser  Tyr Leu Ala Gly Ala  Ser Leu Ile Tyr Thr  Val Thr Arg 
    2495                 2500                 2505             


Asn Ala  Gly Leu Val Lys Arg  Arg Gly Gly Gly Thr  Gly Glu Thr 
    2510                 2515                 2520             


Leu Gly  Glu Lys Trp Lys Ala  Arg Leu Asn Gln Met  Ser Ala Leu 
    2525                 2530                 2535             


Glu Phe  Tyr Ser Tyr Lys Lys  Ser Gly Ile Thr Glu  Val Cys Arg 
    2540                 2545                 2550             


Glu Glu  Ala Arg Arg Ala Leu  Lys Asp Gly Val Ala  Thr Gly Gly 
    2555                 2560                 2565             


His Ala  Val Ser Arg Gly Ser  Ala Lys Ile Arg Trp  Leu Glu Glu 
    2570                 2575                 2580             


Arg Gly  Tyr Leu Gln Pro Tyr  Gly Lys Val Val Asp  Leu Gly Cys 
    2585                 2590                 2595             


Gly Arg  Gly Gly Trp Ser Tyr  Tyr Ala Ala Thr Ile  Arg Lys Val 
    2600                 2605                 2610             


Gln Glu  Val Arg Gly Tyr Thr  Lys Gly Gly Pro Gly  His Glu Glu 
    2615                 2620                 2625             


Pro Met  Leu Val Gln Ser Tyr  Gly Trp Asn Ile Val  Arg Leu Lys 
    2630                 2635                 2640             


Ser Gly  Val Asp Val Phe His  Met Ala Ala Glu Pro  Cys Asp Thr 
    2645                 2650                 2655             


Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Ser Ser Pro  Glu Val Glu 
    2660                 2665                 2670             


Glu Thr  Arg Thr Leu Arg Val  Leu Ser Met Val Gly  Asp Trp Leu 
    2675                 2680                 2685             


Glu Lys  Arg Pro Gly Ala Phe  Cys Ile Lys Val Leu  Cys Pro Tyr 
    2690                 2695                 2700             


Thr Ser  Thr Met Met Glu Thr  Met Glu Arg Leu Gln  Arg Arg His 
    2705                 2710                 2715             


Gly Gly  Gly Leu Val Arg Val  Pro Leu Cys Arg Asn  Ser Thr His 
    2720                 2725                 2730             


Glu Met  Tyr Trp Val Ser Gly  Ala Lys Ser Asn Ile  Ile Lys Ser 
    2735                 2740                 2745             


Val Ser  Thr Thr Ser Gln Leu  Leu Leu Gly Arg Met  Asp Gly Pro 
    2750                 2755                 2760             


Arg Arg  Pro Val Lys Tyr Glu  Glu Asp Val Asn Leu  Gly Ser Gly 
    2765                 2770                 2775             


Thr Arg  Ala Val Ala Ser Cys  Ala Glu Ala Pro Asn  Met Lys Ile 
    2780                 2785                 2790             


Ile Gly  Arg Arg Ile Glu Arg  Ile Arg Asn Glu His  Ala Glu Thr 
    2795                 2800                 2805             


Trp Phe  Leu Asp Glu Asn His  Pro Tyr Arg Thr Trp  Ala Tyr His 
    2810                 2815                 2820             


Gly Ser  Tyr Glu Ala Pro Thr  Gln Gly Ser Ala Ser  Ser Leu Val 
    2825                 2830                 2835             


Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro Trp Asp  Val Val Thr 
    2840                 2845                 2850             


Gly Val  Thr Gly Ile Ala Met  Thr Asp Thr Thr Pro  Tyr Gly Gln 
    2855                 2860                 2865             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Val  Pro Asp Pro 
    2870                 2875                 2880             


Gln Glu  Gly Thr Arg Gln Val  Met Asn Ile Val Ser  Ser Trp Leu 
    2885                 2890                 2895             


Trp Lys  Glu Leu Gly Lys Arg  Lys Arg Pro Arg Val  Cys Thr Lys 
    2900                 2905                 2910             


Glu Glu  Phe Ile Asn Lys Val  Arg Ser Asn Ala Ala  Leu Gly Ala 
    2915                 2920                 2925             


Ile Phe  Glu Glu Glu Lys Glu  Trp Lys Thr Ala Val  Glu Ala Val 
    2930                 2935                 2940             


Asn Asp  Pro Arg Phe Trp Ala  Leu Val Asp Arg Glu  Arg Glu His 
    2945                 2950                 2955             


His Leu  Arg Gly Glu Cys His  Ser Cys Val Tyr Asn  Met Met Gly 
    2960                 2965                 2970             


Lys Arg  Glu Lys Lys Gln Gly  Glu Phe Gly Lys Ala  Lys Gly Ser 
    2975                 2980                 2985             


Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2990                 2995                 3000             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Met  Gly Arg Glu 
    3005                 3010                 3015             


Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly Leu Gln  Arg Leu Gly 
    3020                 3025                 3030             


Tyr Ile  Leu Glu Glu Met Asn  Arg Ala Pro Gly Gly  Lys Met Tyr 
    3035                 3040                 3045             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Ser  Lys Phe Asp 
    3050                 3055                 3060             


Leu Glu  Asn Glu Ala Leu Ile  Thr Asn Gln Met Glu  Glu Gly His 
    3065                 3070                 3075             


Arg Thr  Leu Ala Leu Ala Val  Ile Lys Tyr Thr Tyr  Gln Asn Lys 
    3080                 3085                 3090             


Val Val  Lys Val Leu Arg Pro  Ala Glu Gly Gly Lys  Thr Val Met 
    3095                 3100                 3105             


Asp Ile  Ile Ser Arg Gln Asp  Gln Arg Gly Ser Gly  Gln Val Val 
    3110                 3115                 3120             


Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu Val Val  Gln Leu Ile 
    3125                 3130                 3135             


Arg Asn  Met Glu Ala Glu Glu  Val Leu Glu Met Gln  Asp Leu Trp 
    3140                 3145                 3150             


Leu Leu  Arg Lys Pro Glu Lys  Val Thr Arg Trp Leu  Gln Ser Asn 
    3155                 3160                 3165             


Gly Trp  Asp Arg Leu Lys Arg  Met Ala Val Ser Gly  Asp Asp Cys 
    3170                 3175                 3180             


Val Val  Lys Pro Ile Asp Asp  Arg Phe Ala His Ala  Leu Arg Phe 
    3185                 3190                 3195             


Leu Asn  Asp Met Gly Lys Val  Arg Lys Asp Thr Gln  Glu Trp Lys 
    3200                 3205                 3210             


Pro Ser  Thr Gly Trp Ser Asn  Trp Glu Glu Val Pro  Phe Cys Ser 
    3215                 3220                 3225             


His His  Phe Asn Lys Leu Tyr  Leu Lys Asp Gly Arg  Ser Ile Val 
    3230                 3235                 3240             


Val Pro  Cys Arg His Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Val 
    3245                 3250                 3255             


Ser Pro  Gly Ala Gly Trp Ser  Ile Arg Glu Thr Ala  Cys Leu Ala 
    3260                 3265                 3270             


Lys Ser  Tyr Ala Gln Met Trp  Gln Leu Leu Tyr Phe  His Arg Arg 
    3275                 3280                 3285             


Asp Leu  Arg Leu Met Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val 
    3290                 3295                 3300             


Asp Trp  Val Pro Thr Gly Arg  Thr Thr Trp Ser Ile  His Gly Lys 
    3305                 3310                 3315             


Gly Glu  Trp Met Thr Thr Glu  Asp Met Leu Met Val  Trp Asn Arg 
    3320                 3325                 3330             


Val Trp  Ile Glu Glu Asn Asp  His Met Glu Asp Lys  Thr Pro Val 
    3335                 3340                 3345             


Thr Lys  Trp Thr Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu 
    3350                 3355                 3360             


Trp Cys  Gly Ser Leu Ile Gly  His Arg Pro Arg Thr  Thr Trp Ala 
    3365                 3370                 3375             


Glu Asn  Ile Lys Asp Thr Val  Asn Met Val Arg Arg  Ile Ile Gly 
    3380                 3385                 3390             


Asp Glu  Glu Lys Tyr Met Asp  Tyr Leu Ser Thr Gln  Val Arg Tyr 
    3395                 3400                 3405             


Leu Gly  Glu Glu Gly Ser Thr  Pro Gly Val Leu 
    3410                 3415                 


<210>  21
<211>  3423
<212>  PRT
<213>  Zika virus strain ZikaSPH2015 polyprotein

<400>  21

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser His Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp Tyr Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Met  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  22
<211>  3419
<212>  PRT
<213>  Zika virus strain MR 766 polyprotein

<400>  22

Met Lys Asn Pro Lys Glu Glu Ile Arg Arg Ile Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu 
        435                 440                 445             


Asp Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala 
    450                 455                 460                 


Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr 
465                 470                 475                 480 


Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His 
                485                 490                 495     


Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His 
            500                 505                 510         


Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu 
        515                 520                 525             


Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu 
    530                 535                 540                 


Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu 
545                 550                 555                 560 


Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys 
                565                 570                 575     


Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser 
            580                 585                 590         


Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu 
        595                 600                 605             


His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro 
    610                 615                 620                 


Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro 
625                 630                 635                 640 


Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu 
                645                 650                 655     


Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr 
            660                 665                 670         


Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg 
        675                 680                 685             


Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala 
    690                 695                 700                 


Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val 
705                 710                 715                 720 


Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly 
                725                 730                 735     


Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile 
            740                 745                 750         


Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly 
        755                 760                 765             


Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu 
    770                 775                 780                 


Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe Ser Lys 
785                 790                 795                 800 


Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr Asn Asp Val Glu 
                805                 810                 815     


Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu 
            820                 825                 830         


Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser 
        835                 840                 845             


Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu 
    850                 855                 860                 


Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val Val Val 
865                 870                 875                 880 


Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val 
                885                 890                 895     


Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr 
            900                 905                 910         


Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp 
        915                 920                 925             


Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp Asn Ser Phe Leu 
    930                 935                 940                 


Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp Leu Lys 
945                 950                 955                 960 


Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr 
                965                 970                 975     


Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile 
            980                 985                 990         


Glu Ser Glu Lys Asn Asp Thr Trp  Arg Leu Lys Arg Ala  His Leu Ile 
        995                 1000                 1005             


Glu Met  Lys Thr Cys Glu Trp  Pro Lys Ser His Thr  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Val Glu Glu Ser Asp  Leu Ile Ile Pro Lys  Ser Leu Ala 
    1025                 1030                 1035             


Gly Pro  Leu Ser His His Asn  Thr Arg Glu Gly Tyr  Arg Thr Gln 
    1040                 1045                 1050             


Val Lys  Gly Pro Trp His Ser  Glu Glu Leu Glu Ile  Arg Phe Glu 
    1055                 1060                 1065             


Glu Cys  Pro Gly Thr Lys Val  Tyr Val Glu Glu Thr  Cys Gly Thr 
    1070                 1075                 1080             


Arg Gly  Pro Ser Leu Arg Ser  Thr Thr Ala Ser Gly  Arg Val Ile 
    1085                 1090                 1095             


Glu Glu  Trp Cys Cys Arg Glu  Cys Thr Met Pro Pro  Leu Ser Phe 
    1100                 1105                 1110             


Arg Ala  Lys Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Arg 
    1115                 1120                 1125             


Lys Glu  Pro Glu Ser Asn Leu  Val Arg Ser Met Val  Thr Ala Gly 
    1130                 1135                 1140             


Ser Thr  Asp His Met Asp His  Phe Ser Leu Gly Val  Leu Val Ile 
    1145                 1150                 1155             


Leu Leu  Met Val Gln Glu Gly  Leu Lys Lys Arg Met  Thr Thr Lys 
    1160                 1165                 1170             


Ile Ile  Met Ser Thr Ser Met  Ala Val Leu Val Val  Met Ile Leu 
    1175                 1180                 1185             


Gly Gly  Phe Ser Met Ser Asp  Leu Ala Lys Leu Val  Ile Leu Met 
    1190                 1195                 1200             


Gly Ala  Thr Phe Ala Glu Met  Asn Thr Gly Gly Asp  Val Ala His 
    1205                 1210                 1215             


Leu Ala  Leu Val Ala Ala Phe  Lys Val Arg Pro Ala  Leu Leu Val 
    1220                 1225                 1230             


Ser Phe  Ile Phe Arg Ala Asn  Trp Thr Pro Arg Glu  Ser Met Leu 
    1235                 1240                 1245             


Leu Ala  Leu Ala Ser Cys Leu  Leu Gln Thr Ala Ile  Ser Ala Leu 
    1250                 1255                 1260             


Glu Gly  Asp Leu Met Val Leu  Ile Asn Gly Phe Ala  Leu Ala Trp 
    1265                 1270                 1275             


Leu Ala  Ile Arg Ala Met Ala  Val Pro Arg Thr Asp  Asn Ile Ala 
    1280                 1285                 1290             


Leu Pro  Ile Leu Ala Ala Leu  Thr Pro Leu Ala Arg  Gly Thr Leu 
    1295                 1300                 1305             


Leu Val  Ala Trp Arg Ala Gly  Leu Ala Thr Cys Gly  Gly Ile Met 
    1310                 1315                 1320             


Leu Leu  Ser Leu Lys Gly Lys  Gly Ser Val Lys Lys  Asn Leu Pro 
    1325                 1330                 1335             


Phe Val  Met Ala Leu Gly Leu  Thr Ala Val Arg Val  Val Asp Pro 
    1340                 1345                 1350             


Ile Asn  Val Val Gly Leu Leu  Leu Leu Thr Arg Ser  Gly Lys Arg 
    1355                 1360                 1365             


Ser Trp  Pro Pro Ser Glu Val  Leu Thr Ala Val Gly  Leu Ile Cys 
    1370                 1375                 1380             


Ala Leu  Ala Gly Gly Phe Ala  Lys Ala Asp Ile Glu  Met Ala Gly 
    1385                 1390                 1395             


Pro Met  Ala Ala Val Gly Leu  Leu Ile Val Ser Tyr  Val Val Ser 
    1400                 1405                 1410             


Gly Lys  Ser Val Asp Met Tyr  Ile Glu Arg Ala Gly  Asp Ile Thr 
    1415                 1420                 1425             


Trp Glu  Lys Asp Ala Glu Val  Thr Gly Asn Ser Pro  Arg Leu Asp 
    1430                 1435                 1440             


Val Ala  Leu Asp Glu Ser Gly  Asp Phe Ser Leu Val  Glu Glu Asp 
    1445                 1450                 1455             


Gly Pro  Pro Met Arg Glu Ile  Ile Leu Lys Val Val  Leu Met Ala 
    1460                 1465                 1470             


Ile Cys  Gly Met Asn Pro Ile  Ala Ile Pro Phe Ala  Ala Gly Ala 
    1475                 1480                 1485             


Trp Tyr  Val Tyr Val Lys Thr  Gly Lys Arg Ser Gly  Ala Leu Trp 
    1490                 1495                 1500             


Asp Val  Pro Ala Pro Lys Glu  Val Lys Lys Gly Glu  Thr Thr Asp 
    1505                 1510                 1515             


Gly Val  Tyr Arg Val Met Thr  Arg Arg Leu Leu Gly  Ser Thr Gln 
    1520                 1525                 1530             


Val Gly  Val Gly Val Met Gln  Glu Gly Val Phe His  Thr Met Trp 
    1535                 1540                 1545             


His Val  Thr Lys Gly Ala Ala  Leu Arg Ser Gly Glu  Gly Arg Leu 
    1550                 1555                 1560             


Asp Pro  Tyr Trp Gly Asp Val  Lys Gln Asp Leu Val  Ser Tyr Cys 
    1565                 1570                 1575             


Gly Pro  Trp Lys Leu Asp Ala  Ala Trp Asp Gly Leu  Ser Glu Val 
    1580                 1585                 1590             


Gln Leu  Leu Ala Val Pro Pro  Gly Glu Arg Ala Arg  Asn Ile Gln 
    1595                 1600                 1605             


Thr Leu  Pro Gly Ile Phe Lys  Thr Lys Asp Gly Asp  Ile Gly Ala 
    1610                 1615                 1620             


Val Ala  Leu Asp Tyr Pro Ala  Gly Thr Ser Gly Ser  Pro Ile Leu 
    1625                 1630                 1635             


Asp Lys  Cys Gly Arg Val Ile  Gly Leu Tyr Gly Asn  Gly Val Val 
    1640                 1645                 1650             


Ile Lys  Asn Gly Ser Tyr Val  Ser Ala Ile Thr Gln  Gly Lys Arg 
    1655                 1660                 1665             


Glu Glu  Glu Thr Pro Val Glu  Cys Phe Glu Pro Ser  Met Leu Lys 
    1670                 1675                 1680             


Lys Lys  Gln Leu Thr Val Leu  Asp Leu His Pro Gly  Ala Gly Lys 
    1685                 1690                 1695             


Thr Arg  Arg Val Leu Pro Glu  Ile Val Arg Glu Ala  Ile Lys Lys 
    1700                 1705                 1710             


Arg Leu  Arg Thr Val Ile Leu  Ala Pro Thr Arg Val  Val Ala Ala 
    1715                 1720                 1725             


Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro Val Arg  Tyr Met Thr 
    1730                 1735                 1740             


Thr Ala  Val Asn Val Thr His  Ser Gly Thr Glu Ile  Val Asp Leu 
    1745                 1750                 1755             


Met Cys  His Ala Thr Phe Thr  Ser Arg Leu Leu Gln  Pro Ile Arg 
    1760                 1765                 1770             


Val Pro  Asn Tyr Asn Leu Asn  Ile Met Asp Glu Ala  His Phe Thr 
    1775                 1780                 1785             


Asp Pro  Ser Ser Ile Ala Ala  Arg Gly Tyr Ile Ser  Thr Arg Val 
    1790                 1795                 1800             


Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met Thr Ala  Thr Pro Pro 
    1805                 1810                 1815             


Gly Thr  Arg Asp Ala Phe Pro  Asp Ser Asn Ser Pro  Ile Met Asp 
    1820                 1825                 1830             


Thr Glu  Val Glu Val Pro Glu  Arg Ala Trp Ser Ser  Gly Phe Asp 
    1835                 1840                 1845             


Trp Val  Thr Asp His Ser Gly  Lys Thr Val Trp Phe  Val Pro Ser 
    1850                 1855                 1860             


Val Arg  Asn Gly Asn Glu Ile  Ala Ala Cys Leu Thr  Lys Ala Gly 
    1865                 1870                 1875             


Lys Arg  Val Ile Gln Leu Ser  Arg Lys Thr Phe Glu  Thr Glu Phe 
    1880                 1885                 1890             


Gln Lys  Thr Lys Asn Gln Glu  Trp Asp Phe Val Ile  Thr Thr Asp 
    1895                 1900                 1905             


Ile Ser  Glu Met Gly Ala Asn  Phe Lys Ala Asp Arg  Val Ile Asp 
    1910                 1915                 1920             


Ser Arg  Arg Cys Leu Lys Pro  Val Ile Leu Asp Gly  Glu Arg Val 
    1925                 1930                 1935             


Ile Leu  Ala Gly Pro Met Pro  Val Thr His Ala Ser  Ala Ala Gln 
    1940                 1945                 1950             


Arg Arg  Gly Arg Ile Gly Arg  Asn Pro Asn Lys Pro  Gly Asp Glu 
    1955                 1960                 1965             


Tyr Met  Tyr Gly Gly Gly Cys  Ala Glu Thr Asp Glu  Gly His Ala 
    1970                 1975                 1980             


His Trp  Leu Glu Ala Arg Met  Leu Leu Asp Asn Ile  Tyr Leu Gln 
    1985                 1990                 1995             


Asp Gly  Leu Ile Ala Ser Leu  Tyr Arg Pro Glu Ala  Asp Lys Val 
    2000                 2005                 2010             


Ala Ala  Ile Glu Gly Glu Phe  Lys Leu Arg Thr Glu  Gln Arg Lys 
    2015                 2020                 2025             


Thr Phe  Val Glu Leu Met Lys  Arg Gly Asp Leu Pro  Val Trp Leu 
    2030                 2035                 2040             


Ala Tyr  Gln Val Ala Ser Ala  Gly Ile Thr Tyr Thr  Asp Arg Arg 
    2045                 2050                 2055             


Trp Cys  Phe Asp Gly Thr Thr  Asn Asn Thr Ile Met  Glu Asp Ser 
    2060                 2065                 2070             


Val Pro  Ala Glu Val Trp Thr  Lys Tyr Gly Glu Lys  Arg Val Leu 
    2075                 2080                 2085             


Lys Pro  Arg Trp Met Asp Ala  Arg Val Cys Ser Asp  His Ala Ala 
    2090                 2095                 2100             


Leu Lys  Ser Phe Lys Glu Phe  Ala Ala Gly Lys Arg  Gly Ala Ala 
    2105                 2110                 2115             


Leu Gly  Val Met Glu Ala Leu  Gly Thr Leu Pro Gly  His Met Thr 
    2120                 2125                 2130             


Glu Arg  Phe Gln Glu Ala Ile  Asp Asn Leu Ala Val  Leu Met Arg 
    2135                 2140                 2145             


Ala Glu  Thr Gly Ser Arg Pro  Tyr Lys Ala Ala Ala  Ala Gln Leu 
    2150                 2155                 2160             


Pro Glu  Thr Leu Glu Thr Ile  Met Leu Leu Gly Leu  Leu Gly Thr 
    2165                 2170                 2175             


Val Ser  Leu Gly Ile Phe Phe  Val Leu Met Arg Asn  Lys Gly Ile 
    2180                 2185                 2190             


Gly Lys  Met Gly Phe Gly Met  Val Thr Leu Gly Ala  Ser Ala Trp 
    2195                 2200                 2205             


Leu Met  Trp Leu Ser Glu Ile  Glu Pro Ala Arg Ile  Ala Cys Val 
    2210                 2215                 2220             


Leu Ile  Val Val Phe Leu Leu  Leu Val Val Leu Ile  Pro Glu Pro 
    2225                 2230                 2235             


Glu Lys  Gln Arg Ser Pro Gln  Asp Asn Gln Met Ala  Ile Ile Ile 
    2240                 2245                 2250             


Met Val  Ala Val Gly Leu Leu  Gly Leu Ile Thr Ala  Asn Glu Leu 
    2255                 2260                 2265             


Gly Trp  Leu Glu Arg Thr Lys  Asn Asp Ile Ala His  Leu Met Gly 
    2270                 2275                 2280             


Arg Arg  Glu Glu Gly Ala Thr  Met Gly Phe Ser Met  Asp Ile Asp 
    2285                 2290                 2295             


Leu Arg  Pro Ala Ser Ala Trp  Ala Ile Tyr Ala Ala  Leu Thr Thr 
    2300                 2305                 2310             


Leu Ile  Thr Pro Ala Val Gln  His Ala Val Thr Thr  Ser Tyr Asn 
    2315                 2320                 2325             


Asn Tyr  Ser Leu Met Ala Met  Ala Thr Gln Ala Gly  Val Leu Phe 
    2330                 2335                 2340             


Gly Met  Gly Lys Gly Met Pro  Phe Met His Gly Asp  Leu Gly Val 
    2345                 2350                 2355             


Pro Leu  Leu Met Met Gly Cys  Tyr Ser Gln Leu Thr  Pro Leu Thr 
    2360                 2365                 2370             


Leu Ile  Val Ala Ile Ile Leu  Leu Val Ala His Tyr  Met Tyr Leu 
    2375                 2380                 2385             


Ile Pro  Gly Leu Gln Ala Ala  Ala Ala Arg Ala Ala  Gln Lys Arg 
    2390                 2395                 2400             


Thr Ala  Ala Gly Ile Met Lys  Asn Pro Val Val Asp  Gly Ile Val 
    2405                 2410                 2415             


Val Thr  Asp Ile Asp Thr Met  Thr Ile Asp Pro Gln  Val Glu Lys 
    2420                 2425                 2430             


Lys Met  Gly Gln Val Leu Leu  Ile Ala Val Ala Ile  Ser Ser Ala 
    2435                 2440                 2445             


Val Leu  Leu Arg Thr Ala Trp  Gly Trp Gly Glu Ala  Gly Ala Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Thr Ser Thr  Leu Trp Glu Gly Ser  Pro Asn Lys 
    2465                 2470                 2475             


Tyr Trp  Asn Ser Ser Thr Ala  Thr Ser Leu Cys Asn  Ile Phe Arg 
    2480                 2485                 2490             


Gly Ser  Tyr Leu Ala Gly Ala  Ser Leu Ile Tyr Thr  Val Thr Arg 
    2495                 2500                 2505             


Asn Ala  Gly Leu Val Lys Arg  Arg Gly Gly Gly Thr  Gly Glu Thr 
    2510                 2515                 2520             


Leu Gly  Glu Lys Trp Lys Ala  Arg Leu Asn Gln Met  Ser Ala Leu 
    2525                 2530                 2535             


Glu Phe  Tyr Ser Tyr Lys Lys  Ser Gly Ile Thr Glu  Val Cys Arg 
    2540                 2545                 2550             


Glu Glu  Ala Arg Arg Ala Leu  Lys Asp Gly Val Ala  Thr Gly Gly 
    2555                 2560                 2565             


His Ala  Val Ser Arg Gly Ser  Ala Lys Ile Arg Trp  Leu Glu Glu 
    2570                 2575                 2580             


Arg Gly  Tyr Leu Gln Pro Tyr  Gly Lys Val Val Asp  Leu Gly Cys 
    2585                 2590                 2595             


Gly Arg  Gly Gly Trp Ser Tyr  Tyr Ala Ala Thr Ile  Arg Lys Val 
    2600                 2605                 2610             


Gln Glu  Val Arg Gly Tyr Thr  Lys Gly Gly Pro Gly  His Glu Glu 
    2615                 2620                 2625             


Pro Met  Leu Val Gln Ser Tyr  Gly Trp Asn Ile Val  Arg Leu Lys 
    2630                 2635                 2640             


Ser Gly  Val Asp Val Phe His  Met Ala Ala Glu Pro  Cys Asp Thr 
    2645                 2650                 2655             


Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Ser Ser Pro  Glu Val Glu 
    2660                 2665                 2670             


Glu Thr  Arg Thr Leu Arg Val  Leu Ser Met Val Gly  Asp Trp Leu 
    2675                 2680                 2685             


Glu Lys  Arg Pro Gly Ala Phe  Cys Ile Lys Val Leu  Cys Pro Tyr 
    2690                 2695                 2700             


Thr Ser  Thr Met Met Glu Thr  Met Glu Arg Leu Gln  Arg Arg His 
    2705                 2710                 2715             


Gly Gly  Gly Leu Val Arg Val  Pro Leu Cys Arg Asn  Ser Thr His 
    2720                 2725                 2730             


Glu Met  Tyr Trp Val Ser Gly  Ala Lys Ser Asn Ile  Ile Lys Ser 
    2735                 2740                 2745             


Val Ser  Thr Thr Ser Gln Leu  Leu Leu Gly Arg Met  Asp Gly Pro 
    2750                 2755                 2760             


Arg Arg  Pro Val Lys Tyr Glu  Glu Asp Val Asn Leu  Gly Ser Gly 
    2765                 2770                 2775             


Thr Arg  Ala Val Ala Ser Cys  Ala Glu Ala Pro Asn  Met Lys Ile 
    2780                 2785                 2790             


Ile Gly  Arg Arg Ile Glu Arg  Ile Arg Asn Glu His  Ala Glu Thr 
    2795                 2800                 2805             


Trp Phe  Leu Asp Glu Asn His  Pro Tyr Arg Thr Trp  Ala Tyr His 
    2810                 2815                 2820             


Gly Ser  Tyr Glu Ala Pro Thr  Gln Gly Ser Ala Ser  Ser Leu Val 
    2825                 2830                 2835             


Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro Trp Asp  Val Val Thr 
    2840                 2845                 2850             


Gly Val  Thr Gly Ile Ala Met  Thr Asp Thr Thr Pro  Tyr Gly Gln 
    2855                 2860                 2865             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Val  Pro Asp Pro 
    2870                 2875                 2880             


Gln Glu  Gly Thr Arg Gln Val  Met Asn Ile Val Ser  Ser Trp Leu 
    2885                 2890                 2895             


Trp Lys  Glu Leu Gly Lys Arg  Lys Arg Pro Arg Val  Cys Thr Lys 
    2900                 2905                 2910             


Glu Glu  Phe Ile Asn Lys Val  Arg Ser Asn Ala Ala  Leu Gly Ala 
    2915                 2920                 2925             


Ile Phe  Glu Glu Glu Lys Glu  Trp Lys Thr Ala Val  Glu Ala Val 
    2930                 2935                 2940             


Asn Asp  Pro Arg Phe Trp Ala  Leu Val Asp Arg Glu  Arg Glu His 
    2945                 2950                 2955             


His Leu  Arg Gly Glu Cys His  Ser Cys Val Tyr Asn  Met Met Gly 
    2960                 2965                 2970             


Lys Arg  Glu Lys Lys Gln Gly  Glu Phe Gly Lys Ala  Lys Gly Ser 
    2975                 2980                 2985             


Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2990                 2995                 3000             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Met  Gly Arg Glu 
    3005                 3010                 3015             


Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly Leu Gln  Arg Leu Gly 
    3020                 3025                 3030             


Tyr Ile  Leu Glu Glu Met Asn  Arg Ala Pro Gly Gly  Lys Met Tyr 
    3035                 3040                 3045             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Ser  Lys Phe Asp 
    3050                 3055                 3060             


Leu Glu  Asn Glu Ala Leu Ile  Thr Asn Gln Met Glu  Glu Gly His 
    3065                 3070                 3075             


Arg Thr  Leu Ala Leu Ala Val  Ile Lys Tyr Thr Tyr  Gln Asn Lys 
    3080                 3085                 3090             


Val Val  Lys Val Leu Arg Pro  Ala Glu Gly Gly Lys  Thr Val Met 
    3095                 3100                 3105             


Asp Ile  Ile Ser Arg Gln Asp  Gln Arg Gly Ser Gly  Gln Val Val 
    3110                 3115                 3120             


Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu Val Val  Gln Leu Ile 
    3125                 3130                 3135             


Arg Asn  Met Glu Ala Glu Glu  Val Leu Glu Met Gln  Asp Leu Trp 
    3140                 3145                 3150             


Leu Leu  Arg Lys Pro Glu Lys  Val Thr Arg Trp Leu  Gln Ser Asn 
    3155                 3160                 3165             


Gly Trp  Asp Arg Leu Lys Arg  Met Ala Val Ser Gly  Asp Asp Cys 
    3170                 3175                 3180             


Val Val  Lys Pro Ile Asp Asp  Arg Phe Ala His Ala  Leu Arg Phe 
    3185                 3190                 3195             


Leu Asn  Asp Met Gly Lys Val  Arg Lys Asp Thr Gln  Glu Trp Lys 
    3200                 3205                 3210             


Pro Ser  Thr Gly Trp Ser Asn  Trp Glu Glu Val Pro  Phe Cys Ser 
    3215                 3220                 3225             


His His  Phe Asn Lys Leu Tyr  Leu Lys Asp Gly Arg  Ser Ile Val 
    3230                 3235                 3240             


Val Pro  Cys Arg His Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Val 
    3245                 3250                 3255             


Ser Pro  Gly Ala Gly Trp Ser  Ile Arg Glu Thr Ala  Cys Leu Ala 
    3260                 3265                 3270             


Lys Ser  Tyr Ala Gln Met Trp  Gln Leu Leu Tyr Phe  His Arg Arg 
    3275                 3280                 3285             


Asp Leu  Arg Leu Met Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val 
    3290                 3295                 3300             


Asp Trp  Val Pro Thr Gly Arg  Thr Thr Trp Ser Ile  His Gly Lys 
    3305                 3310                 3315             


Gly Glu  Trp Met Thr Thr Glu  Asp Met Leu Met Val  Trp Asn Arg 
    3320                 3325                 3330             


Val Trp  Ile Glu Glu Asn Asp  His Met Glu Asp Lys  Thr Pro Val 
    3335                 3340                 3345             


Thr Lys  Trp Thr Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu 
    3350                 3355                 3360             


Trp Cys  Gly Ser Leu Ile Gly  His Arg Pro Arg Thr  Thr Trp Ala 
    3365                 3370                 3375             


Glu Asn  Ile Lys Asp Thr Val  Asn Met Val Arg Arg  Ile Ile Gly 
    3380                 3385                 3390             


Asp Glu  Glu Lys Tyr Met Asp  Tyr Leu Ser Thr Gln  Val Arg Tyr 
    3395                 3400                 3405             


Leu Gly  Glu Glu Gly Ser Thr  Pro Gly Val Leu 
    3410                 3415                 


<210>  23
<211>  3423
<212>  PRT
<213>  Zika virus strain BeH815744 polyprotein

<400>  23

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asp 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  24
<211>  3423
<212>  PRT
<213>  Zika virus strain BeH819966 polyprotein

<400>  24

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  25
<211>  3423
<212>  PRT
<213>  Zika virus strain BeH819015 polyprotein

<400>  25

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  26
<211>  3423
<212>  PRT
<213>  Zika virus isolate Z1106033 polyprotein

<400>  26

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Thr Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Ala Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  27
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:1/14

<400>  27

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  28
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:2/15

<400>  28

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  29
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:3/16

<400>  29

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  30
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:4/17

<400>  30

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  31
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:5/18

<400>  31

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  32
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:6/19

<400>  32

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  33
<211>  399
<212>  PRT
<213>  sE of SEQ ID NO:7/20

<400>  33

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu Asp Arg 
145                 150                 155                 160 


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
                165                 170                 175     


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
            180                 185                 190         


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
        195                 200                 205             


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
    210                 215                 220                 


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
225                 230                 235                 240 


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
                245                 250                 255     


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
            260                 265                 270         


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
        275                 280                 285             


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
    290                 295                 300                 


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
305                 310                 315                 320 


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
                325                 330                 335     


Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
            340                 345                 350         


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
        355                 360                 365             


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
    370                 375                 380                 


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser 
385                 390                 395                 


<210>  34
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:8/21

<400>  34

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  35
<211>  399
<212>  PRT
<213>  sE of SEQ ID NO:9/22

<400>  35

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu Asp Arg 
145                 150                 155                 160 


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
                165                 170                 175     


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
            180                 185                 190         


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
        195                 200                 205             


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
    210                 215                 220                 


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
225                 230                 235                 240 


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
                245                 250                 255     


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
            260                 265                 270         


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
        275                 280                 285             


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
    290                 295                 300                 


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
305                 310                 315                 320 


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
                325                 330                 335     


Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
            340                 345                 350         


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
        355                 360                 365             


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
    370                 375                 380                 


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser 
385                 390                 395                 


<210>  36
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:10/23

<400>  36

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  37
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:11/24

<400>  37

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  38
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:12/25

<400>  38

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  39
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:13/26

<400>  39

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  40
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:1/14

<400>  40

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  41
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:2/15

<400>  41

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  42
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:3/16

<400>  42

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  43
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:4/17

<400>  43

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  44
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:5/18

<400>  44

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  45
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:6/19

<400>  45

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  46
<211>  500
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:7/20

<400>  46

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu Asp Arg 
145                 150                 155                 160 


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
                165                 170                 175     


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
            180                 185                 190         


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
        195                 200                 205             


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
    210                 215                 220                 


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
225                 230                 235                 240 


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
                245                 250                 255     


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
            260                 265                 270         


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
        275                 280                 285             


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
    290                 295                 300                 


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
305                 310                 315                 320 


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
                325                 330                 335     


Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
            340                 345                 350         


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
        355                 360                 365             


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
    370                 375                 380                 


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
385                 390                 395                 400 


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
                405                 410                 415     


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
            420                 425                 430         


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
        435                 440                 445             


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
    450                 455                 460                 


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
                485                 490                 495     


Ala Val Ser Ala 
            500 


<210>  47
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:8/21

<400>  47

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  48
<211>  500
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:9/22

<400>  48

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu Asp Arg 
145                 150                 155                 160 


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
                165                 170                 175     


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
            180                 185                 190         


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
        195                 200                 205             


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
    210                 215                 220                 


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
225                 230                 235                 240 


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
                245                 250                 255     


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
            260                 265                 270         


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
        275                 280                 285             


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
    290                 295                 300                 


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
305                 310                 315                 320 


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
                325                 330                 335     


Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
            340                 345                 350         


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
        355                 360                 365             


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
    370                 375                 380                 


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
385                 390                 395                 400 


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
                405                 410                 415     


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
            420                 425                 430         


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
        435                 440                 445             


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
    450                 455                 460                 


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
                485                 490                 495     


Ala Val Ser Ala 
            500 


<210>  49
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:10/23

<400>  49

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  50
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:11/24

<400>  50

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  51
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:12/25

<400>  51

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  52
<211>  504
<212>  PRT
<213>  E protein + stem-anchor of SEQ ID NO:13/26

<400>  52

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Ala Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  53
<211>  1773
<212>  DNA
<213>  Insert sE no codon optimization

<400>  53
agacgaggcg cagatactag tgtcggaatt gttggcctcc tgctgaccac agctatggca       60

gcggaggtca ctagacgtgg gagtgcatac tatatgtact tggacagaaa cgatgctggg      120

gaggccatat cttttccaac cacattgggg atgaataagt gttatataca gatcatggat      180

cttggacaca tgtgtgatgc caccatgagc tatgaatgcc ctatgctgga tgagggggtg      240

gaaccagatg acgtcgattg ttggtgcaac acgacgtcaa cttgggttgt gtacggaacc      300

tgccatcaca aaaaaggtga agcacggaga tctagaagag ctgtgacgct cccctcccat      360

tccactagga agctgcaaac gcggtcgcaa acctggttgg aatcaagaga atacacaaag      420

cacttgatta gagtcgaaaa ttggatattt aggaaccctg gcttcgcgtt agcagcagct      480

gccatcgctt ggcttttggg aagctcaacg agccaaaaag tcatatactt ggtcatgata      540

ctgctgattg ccccggcata cagcatcagg tgcataggag tcagcaatag ggactttgtg      600

gaaggtatgt caggtgggac ctgggttgat gttgtcttgg aacatggagg ttgtgtcacc      660

gtaatggcac aggacaaacc gactgtcgac atagagctgg ttacaacaac agtcagcaac      720

atggcggagg taagatccta ctgctatgag gcatcaatat cagacatggc ttcggacagc      780

cgctgcccaa cacaaggtga agcctacctt gacaagcaat cagacactca atatgtctgc      840

aaaagaacgt tagtggacag aggctgggga aatggatgtg gactttttgg caaagggagc      900

ctggtgacat gcgctaagtt tgcatgctcc aagaaaatga ccgggaagag catccagcca      960

gagaatctgg agtaccggat aatgctgtca gttcatggct cccagcacag tgggatgatt     1020

gttaatgaca caggacatga aactgatgag aatagagcga aagttgagat aacgcccaat     1080

tcaccaagag ccgaagccac cctggggggt tttggaagcc taggacttga ttgtgaaccg     1140

aggacaggcc ttgacttttc agatttgtat tacttgacta tgaataacaa gcactggttg     1200

gttcacaagg agtggttcca cgacattcca ttaccttggc acgctggggc agacaccgga     1260

actccacact ggaacaacaa agaagcactg gtagagttca aggacgcaca tgccaaaagg     1320

caaactgtcg tggttctagg gagtcaagaa ggagcagttc acacggccct tgctggagct     1380

ctggaggctg agatggatgg tgcaaaggga aggctgtcct ctggccactt gaaatgtcgc     1440

ctgaaaatgg ataaacttag attgaagggc gtgtcatact ccttgtgtac tgcagcgttc     1500

acattcacca agatcccggc tgaaacactg cacgggacag tcacagtgga ggtacagtac     1560

gcagggacag atggaccttg caaggttcca gctcagatgg cggtggacat gcaaactctg     1620

accccagttg ggaggttgat aaccgctaac cccgtaatca ctgaaagcac tgagaactct     1680

aagatgatgc tggaacttga tccaccattt ggggactctt acattgtcat aggagtcggg     1740

gagaagaaga tcacccacca ctggcacagg agt                                  1773


<210>  54
<211>  2076
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Insert RSP no codon optimization L107D

<400>  54
agacgaggcg cagatactag tgtcggaatt gttggcctcc tgctgaccac agctatggca       60

gcggaggtca ctagacgtgg gagtgcatac tatatgtact tggacagaaa cgatgctggg      120

gaggccatat cttttccaac cacattgggg atgaataagt gttatataca gatcatggat      180

cttggacaca tgtgtgatgc caccatgagc tatgaatgcc ctatgctgga tgagggggtg      240

gaaccagatg acgtcgattg ttggtgcaac acgacgtcaa cttgggttgt gtacggaacc      300

tgccatcaca aaaaaggtga agcacggaga tctagaagag ctgtgacgct cccctcccat      360

tccactagga agctgcaaac gcggtcgcaa acctggttgg aatcaagaga atacacaaag      420

cacttgatta gagtcgaaaa ttggatattt aggaaccctg gcttcgcgtt agcagcagct      480

gccatcgctt ggcttttggg aagctcaacg agccaaaaag tcatatactt ggtcatgata      540

ctgctgattg ccccggcata cagcatcagg tgcataggag tcagcaatag ggactttgtg      600

gaaggtatgt caggtgggac ctgggttgat gttgtcttgg aacatggagg ttgtgtcacc      660

gtaatggcac aggacaaacc gactgtcgac atagagctgg ttacaacaac agtcagcaac      720

atggcggagg taagatccta ctgctatgag gcatcaatat cagacatggc ttcggacagc      780

cgctgcccaa cacaaggtga agcctacctt gacaagcaat cagacactca atatgtctgc      840

aaaagaacgt tagtggacag aggctgggga aatggatgtg gagactttgg caaagggagc      900

ctggtgacat gcgctaagtt tgcatgctcc aagaaaatga ccgggaagag catccagcca      960

gagaatctgg agtaccggat aatgctgtca gttcatggct cccagcacag tgggatgatt     1020

gttaatgaca caggacatga aactgatgag aatagagcga aagttgagat aacgcccaat     1080

tcaccaagag ccgaagccac cctggggggt tttggaagcc taggacttga ttgtgaaccg     1140

aggacaggcc ttgacttttc agatttgtat tacttgacta tgaataacaa gcactggttg     1200

gttcacaagg agtggttcca cgacattcca ttaccttggc acgctggggc agacaccgga     1260

actccacact ggaacaacaa agaagcactg gtagagttca aggacgcaca tgccaaaagg     1320

caaactgtcg tggttctagg gagtcaagaa ggagcagttc acacggccct tgctggagct     1380

ctggaggctg agatggatgg tgcaaaggga aggctgtcct ctggccactt gaaatgtcgc     1440

ctgaaaatgg ataaacttag attgaagggc gtgtcatact ccttgtgtac tgcagcgttc     1500

acattcacca agatcccggc tgaaacactg cacgggacag tcacagtgga ggtacagtac     1560

gcagggacag atggaccttg caaggttcca gctcagatgg cggtggacat gcaaactctg     1620

accccagttg ggaggttgat aaccgctaac cccgtaatca ctgaaagcac tgagaactct     1680

aagatgatgc tggaacttga tccaccattt ggggactctt acattgtcat aggagtcggg     1740

gagaagaaga tcacccacca ctggcacagg agtggcagca ccattggaaa agcatttgaa     1800

gccactgtga gaggtgccaa gagaatggca gtcttgggag acacagcctg ggactttgga     1860

tcagttggag gcgctctcaa ctcattgggc aagggcatcc atcaaatttt tggagcagct     1920

ttcaaatcat tgtttggagg aatgtcctgg ttctcacaaa ttctcattgg aacgttgctg     1980

atgtggttgg gtctgaacac aaagaatgga tctatttccc ttatgtgctt ggccttaggg     2040

ggagtgttga tcttcttatc cacagccgtc tctgct                               2076


<210>  55
<211>  1773
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Insert sE codon optimization (human)

<400>  55
cgcagaggag cggatacgtc agttggcatt gtgggcttgc tcctcaccac cgctatggcc       60

gcagaagtta caagaagagg gtctgcctac tacatgtatc tggacaggaa cgatgctggc      120

gaagccatct cctttcccac aaccctgggg atgaacaagt gctacattca gatcatggat      180

cttggtcaca tgtgcgatgc cacaatgtcc tatgagtgtc ccatgctcga tgagggcgtc      240

gagcctgacg acgttgattg ctggtgtaac accaccagca cctgggtggt ctatggcact      300

tgccatcaca agaagggtga agcacggagg tcacgacggg cagtgacatt gccaagtcat      360

agcactagga aactgcagac tcgctcccag acctggcttg aatcccgaga gtacacgaaa      420

cacctcattc gtgtggagaa ctggatcttc cggaatcccg ggtttgccct ggctgctgcc      480

gctattgcct ggttgctcgg ctctagcaca tcacagaaag tcatctacct ggtgatgatc      540

ttgctcattg ctccagccta ctctatcaga tgcatcggag tttccaatcg tgactttgtc      600

gaagggatgt ccggaggcac ctgggttgac gtggtgcttg agcatggtgg ctgcgtaacg      660

gtaatggctc aggacaaacc cacggttgac atagaactgg tgaccacgac tgtcagtaat      720

atggccgaag tgcgaagcta ctgctatgag gcctctatct ctgacatggc atcagacagc      780

cggtgtccaa ctcaaggcga agcttatctg gacaagcaat ccgatacaca gtacgtgtgc      840

aagcggactc tcgtggatag aggttggggc aatgggtgtg gtctgtttgg gaaaggcagt      900

ctggtaacat gcgcaaagtt cgcatgttcc aagaaaatga caggaaagag cattcagccg      960

gaaaatctgg agtataggat tatgctcagc gtgcatggga gccagcacag tggcatgatt     1020

gtcaatgata caggccacga aaccgacgag aacagagcga aggttgagat cactcccaat     1080

tcacctcgcg cagaggccac tctgggaggg tttggaagtc tcggtctgga ctgtgaacct     1140

cgcactggcc tggacttcag cgatctgtat tacctgacga tgaacaacaa gcattggctg     1200

gtccataagg agtggttcca tgatattccg cttccttggc atgccggagc cgataccgga     1260

acaccccact ggaacaacaa agaggctttg gtggagttca aagatgcaca cgctaagcgc     1320

caaaccgtcg tggtcctggg tagccaagaa ggagcggttc acactgcgct tgccggagcc     1380

ctggaggcgg aaatggatgg ggccaaaggg cgcctttcca gtggacacct gaagtgtcgg     1440

ctgaaaatgg acaagctgag actgaaaggt gtgtcttaca gcctgtgcac cgcagccttc     1500

actttcacca aaatccctgc tgaaaccttg cacggaacag tgacagtaga ggtgcagtat     1560

gcaggcacag atggcccatg taaggtgcca gctcagatgg cagtggacat gcagaccctg     1620

actccagtgg gaaggctcat aactgccaat ccggtcatca cagagtctac cgagaactca     1680

aagatgatgc tggagctgga ccctcccttt ggggactctt acatagtcat aggggtaggc     1740

gagaagaaaa tcacccatca ctggcacagg agc                                  1773


<210>  56
<211>  2076
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Insert RSP codon optimization (human) L107D

<400>  56
cgcagaggcg ctgatacctc agttggtata gtgggattgc tgttgacaac cgccatggcc       60

gcagaagtga cgagaagggg ttctgcctac tatatgtacc ttgatcggaa tgacgctgga      120

gaggcaatct cattcccgac caccttgggc atgaacaaat gctacatcca gattatggac      180

ctgggacata tgtgcgatgc cactatgagc tatgagtgcc ccatgctgga tgagggagta      240

gagcctgacg atgttgactg ctggtgtaac accactagta catgggtggt gtacggaacg      300

tgccaccaca agaaaggaga agctcgaaga tcccgtcgcg cggttactct tccctcccat      360

tccacaagga aactccaaac ccgtagccag acatggcttg aaagccgaga atacactaaa      420

cacttgatac gggtagagaa ctggattttc cgcaatcccg ggtttgctct tgcagctgcg      480

gcaattgctt ggctcctcgg gtcaagcaca tcccagaagg tgatctacct ggtgatgatc      540

ctgctgattg caccagccta ttcaatccgg tgtatcggtg tctcaaatcg tgacttcgtc      600

gaggggatga gtggcgggac ctgggtggat gtcgttctgg aacatggagg ctgtgtaacg      660

gtgatggctc aagacaagcc aaccgttgac atcgaactgg taacgacgac agtcagcaat      720

atggccgaag tccgctctta ctgctatgaa gccagcatca gcgatatggc cagcgatagt      780

cgatgtccga ctcaaggcga agcctatctc gacaaacagt ctgacaccca gtacgtgtgc      840

aagaggactc tcgtggatag agggtggggc aatggttgtg gggatttcgg caaggggtca      900

ctggtaacct gtgcaaagtt cgcctgctct aagaagatga ctgggaagag tatccagccc      960

gagaatctgg agtataggat catgctgagc gttcatggat cccagcatag cgggatgatc     1020

gtgaatgata cgggtcacga aacagacgag aaccgcgcaa aggtcgagat tactcccaat     1080

tcccctaggg ccgaagccac actcggaggc tttggcagtc tcggcctgga ttgcgagcct     1140

cgcactggac tggatttctc cgacctgtac tacctgacta tgaacaacaa acattggctg     1200

gtgcacaagg aatggtttca cgacattccc ctgccttggc acgctggggc tgacactggt     1260

acacctcatt ggaacaacaa agaggctctg gtggagttca aagatgcaca tgccaagaga     1320

caaaccgtgg tggttctggg atcacaggaa ggcgccgtgc ataccgcgct tgccggagca     1380

ctggaagcag agatggacgg tgctaaaggc cggttgagct ctggccacct taagtgtcgg     1440

ctgaagatgg acaagctgag attgaaagga gtctcctata gtctgtgtac agccgcgttt     1500

acctttacga aaatccccgc tgagacactg cacggaacag tgaccgtgga ggtgcaatat     1560

gcagggactg atggcccatg taaggtgcca gcacagatgg ctgttgacat gcagactctc     1620

accccagtcg gcaggcttat tactgccaat ccggtcataa ccgagagtac agagaatagc     1680

aagatgatgc tggagcttga ccctccattc ggagactcct acattgtcat tggcgtcggt     1740

gagaagaaga ttacccacca ctggcacagg tctggctcca caatcggtaa agccttcgaa     1800

gcgacagtga gaggagccaa acggatggcg gtactcggag acacagcctg ggatttcggg     1860

agcgttggtg gcgctctgaa ctctctcggg aaaggtatcc accagatatt tggggcagcc     1920

tttaaatcac tctttggcgg catgagctgg ttttctcaga tcctgattgg gaccctcctg     1980

atgtggctgg ggctgaacac caagaacggc tctataagcc tgatgtgctt ggccctgggc     2040

ggggtgttga ttttcctgtc caccgctgtg agtgcc                               2076


<210>  57
<211>  20896
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MV Zika sE codon optimization (human)

<400>  57
tcatgaacgc ggccgctaat acgactcact atagggccaa ctttgtttgg tctgatgagt       60

ccgtgaggac gaaacccgga gtcccgggtc accaaacaaa gttgggtaag gatagttcaa      120

tcaatgatca tcttctagtg cacttaggat tcaagatcct attatcaggg acaagagcag      180

gattagggat atccgagatg gccacacttt taaggagctt agcattgttc aaaagaaaca      240

aggacaaacc acccattaca tcaggatccg gtggagccat cagaggaatc aaacacatta      300

ttatagtacc aatccctgga gattcctcaa ttaccactcg atccagactt ctggaccggt      360

tggtgaggtt aattggaaac ccggatgtga gcgggcccaa actaacaggg gcactaatag      420

gtatattatc cttatttgtg gagtctccag gtcaattgat tcagaggatc accgatgacc      480

ctgacgttag cataaggctg ttagaggttg tccagagtga ccagtcacaa tctggcctta      540

ccttcgcatc aagaggtacc aacatggagg atgaggcgga ccaatacttt tcacatgatg      600

atccaattag tagtgatcaa tccaggttcg gatggttcgg gaacaaggaa atctcagata      660

ttgaagtgca agaccctgag ggattcaaca tgattctggg taccatccta gcccaaattt      720

gggtcttgct cgcaaaggcg gttacggccc cagacacggc agctgattcg gagctaagaa      780

ggtggataaa gtacacccaa caaagaaggg tagttggtga atttagattg gagagaaaat      840

ggttggatgt ggtgaggaac aggattgccg aggacctctc cttacgccga ttcatggtcg      900

ctctaatcct ggatatcaag agaacacccg gaaacaaacc caggattgct gaaatgatat      960

gtgacattga tacatatatc gtagaggcag gattagccag ttttatcctg actattaagt     1020

ttgggataga aactatgtat cctgctcttg gactgcatga atttgctggt gagttatcca     1080

cacttgagtc cttgatgaac ctttaccagc aaatggggga aactgcaccc tacatggtaa     1140

tcctggagaa ctcaattcag aacaagttca gtgcaggatc ataccctctg ctctggagct     1200

atgccatggg agtaggagtg gaacttgaaa actccatggg aggtttgaac tttggccgat     1260

cttactttga tccagcatat tttagattag ggcaagagat ggtaaggagg tcagctggaa     1320

aggtcagttc cacattggca tctgaactcg gtatcactgc cgaggatgca aggcttgttt     1380

cagagattgc aatgcatact actgaggaca agatcagtag agcggttgga cccagacaag     1440

cccaagtatc atttctacac ggtgatcaaa gtgagaatga gctaccgaga ttggggggca     1500

aggaagatag gagggtcaaa cagagtcgag gagaagccag ggagagctac agagaaaccg     1560

ggcccagcag agcaagtgat gcgagagctg cccatcttcc aaccggcaca cccctagaca     1620

ttgacactgc aacggagtcc agccaagatc cgcaggacag tcgaaggtca gctgacgccc     1680

tgcttaggct gcaagccatg gcaggaatct cggaagaaca aggctcagac acggacaccc     1740

ctatagtgta caatgacaga aatcttctag actaggtgcg agaggccgag ggccagaaca     1800

acatccgcct accatccatc attgttataa aaaacttagg aaccaggtcc acacagccgc     1860

cagcccatca accatccact cccacgattg gagccaatgg cagaagagca ggcacgccat     1920

gtcaaaaacg gactggaatg catccgggct ctcaaggccg agcccatcgg ctcactggcc     1980

atcgaggaag ctatggcagc atggtcagaa atatcagaca acccaggaca ggagcgagcc     2040

acctgcaggg aagagaaggc aggcagttcg ggtctcagca aaccatgcct ctcagcaatt     2100

ggatcaactg aaggcggtgc acctcgcatc cgcggtcagg gacctggaga gagcgatgac     2160

gacgctgaaa ctttgggaat ccccccaaga aatctccagg catcaagcac tgggttacag     2220

tgttattacg tttatgatca cagcggtgaa gcggttaagg gaatccaaga tgctgactct     2280

atcatggttc aatcaggcct tgatggtgat agcaccctct caggaggaga caatgaatct     2340

gaaaacagcg atgtggatat tggcgaacct gataccgagg gatatgctat cactgaccgg     2400

ggatctgctc ccatctctat ggggttcagg gcttctgatg ttgaaactgc agaaggaggg     2460

gagatccacg agctcctgag actccaatcc agaggcaaca actttccgaa gcttgggaaa     2520

actctcaatg ttcctccgcc cccggacccc ggtagggcca gcacttccgg gacacccatt     2580

aaaaagggca cagacgcgag attagcctca tttggaacgg agatcgcgtc tttattgaca     2640

ggtggtgcaa cccaatgtgc tcgaaagtca ccctcggaac catcagggcc aggtgcacct     2700

gcggggaatg tccccgagtg tgtgagcaat gccgcactga tacaggagtg gacacccgaa     2760

tctggtacca caatctcccc gagatcccag aataatgaag aagggggaga ctattatgat     2820

gatgagctgt tctctgatgt ccaagatatt aaaacagcct tggccaaaat acacgaggat     2880

aatcagaaga taatctccaa gctagaatca ctgctgttat tgaagggaga agttgagtca     2940

attaagaagc agatcaacag gcaaaatatc agcatatcca ccctggaagg acacctctca     3000

agcatcatga tcgccattcc tggacttggg aaggatccca acgaccccac tgcagatgtc     3060

gaaatcaatc ccgacttgaa acccatcata ggcagagatt caggccgagc actggccgaa     3120

gttctcaaga aacccgttgc cagccgacaa ctccaaggaa tgacaaatgg acggaccagt     3180

tccagaggac agctgctgaa ggaatttcag ctaaagccga tcgggaaaaa gatgagctca     3240

gccgtcgggt ttgttcctga caccggccct gcatcacgca gtgtaatccg ctccattata     3300

aaatccagcc ggctagagga ggatcggaag cgttacctga tgactctcct tgatgatatc     3360

aaaggagcca atgatcttgc caagttccac cagatgctga tgaagataat aatgaagtag     3420

ctacagctca acttacctgc caaccccatg ccagtcgacc caactagcct accctccatc     3480

attgttataa aaaacttagg aaccaggtcc acacagccgc cagcccatca acgcgtacgg     3540

ccaccatggc acgcagagga gcggatacgt cagttggcat tgtgggcttg ctcctcacca     3600

ccgctatggc cgcagaagtt acaagaagag ggtctgccta ctacatgtat ctggacagga     3660

acgatgctgg cgaagccatc tcctttccca caaccctggg gatgaacaag tgctacattc     3720

agatcatgga tcttggtcac atgtgcgatg ccacaatgtc ctatgagtgt cccatgctcg     3780

atgagggcgt cgagcctgac gacgttgatt gctggtgtaa caccaccagc acctgggtgg     3840

tctatggcac ttgccatcac aagaagggtg aagcacggag gtcacgacgg gcagtgacat     3900

tgccaagtca tagcactagg aaactgcaga ctcgctccca gacctggctt gaatcccgag     3960

agtacacgaa acacctcatt cgtgtggaga actggatctt ccggaatccc gggtttgccc     4020

tggctgctgc cgctattgcc tggttgctcg gctctagcac atcacagaaa gtcatctacc     4080

tggtgatgat cttgctcatt gctccagcct actctatcag atgcatcgga gtttccaatc     4140

gtgactttgt cgaagggatg tccggaggca cctgggttga cgtggtgctt gagcatggtg     4200

gctgcgtaac ggtaatggct caggacaaac ccacggttga catagaactg gtgaccacga     4260

ctgtcagtaa tatggccgaa gtgcgaagct actgctatga ggcctctatc tctgacatgg     4320

catcagacag ccggtgtcca actcaaggcg aagcttatct ggacaagcaa tccgatacac     4380

agtacgtgtg caagcggact ctcgtggata gaggttgggg caatgggtgt ggtctgtttg     4440

ggaaaggcag tctggtaaca tgcgcaaagt tcgcatgttc caagaaaatg acaggaaaga     4500

gcattcagcc ggaaaatctg gagtatagga ttatgctcag cgtgcatggg agccagcaca     4560

gtggcatgat tgtcaatgat acaggccacg aaaccgacga gaacagagcg aaggttgaga     4620

tcactcccaa ttcacctcgc gcagaggcca ctctgggagg gtttggaagt ctcggtctgg     4680

actgtgaacc tcgcactggc ctggacttca gcgatctgta ttacctgacg atgaacaaca     4740

agcattggct ggtccataag gagtggttcc atgatattcc gcttccttgg catgccggag     4800

ccgataccgg aacaccccac tggaacaaca aagaggcttt ggtggagttc aaagatgcac     4860

acgctaagcg ccaaaccgtc gtggtcctgg gtagccaaga aggagcggtt cacactgcgc     4920

ttgccggagc cctggaggcg gaaatggatg gggccaaagg gcgcctttcc agtggacacc     4980

tgaagtgtcg gctgaaaatg gacaagctga gactgaaagg tgtgtcttac agcctgtgca     5040

ccgcagcctt cactttcacc aaaatccctg ctgaaacctt gcacggaaca gtgacagtag     5100

aggtgcagta tgcaggcaca gatggcccat gtaaggtgcc agctcagatg gcagtggaca     5160

tgcagaccct gactccagtg ggaaggctca taactgccaa tccggtcatc acagagtcta     5220

ccgagaactc aaagatgatg ctggagctgg accctccctt tggggactct tacatagtca     5280

taggggtagg cgagaagaaa atcacccatc actggcacag gagctaatga taagcgcgca     5340

gcgcttagac gtctcgcgat cgatactagt acaacctaaa tccattataa aaaacttagg     5400

agcaaagtga ttgcctccca aggtccacaa tgacagagac ctacgacttc gacaagtcgg     5460

catgggacat caaagggtcg atcgctccga tacaacccac cacctacagt gatggcaggc     5520

tggtgcccca ggtcagagtc atagatcctg gtctaggcga caggaaggat gaatgcttta     5580

tgtacatgtt tctgctgggg gttgttgagg acagcgattc cctagggcct ccaatcgggc     5640

gagcatttgg gttcctgccc ttaggtgttg gcagatccac agcaaagccc gaaaaactcc     5700

tcaaagaggc cactgagctt gacatagttg ttagacgtac agcagggctc aatgaaaaac     5760

tggtgttcta caacaacacc ccactaactc tcctcacacc ttggagaaag gtcctaacaa     5820

cagggagtgt cttcaacgca aaccaagtgt gcaatgcggt taatctgata ccgctcgata     5880

ccccgcagag gttccgtgtt gtttatatga gcatcacccg tctttcggat aacgggtatt     5940

acaccgttcc tagaagaatg ctggaattca gatcggtcaa tgcagtggcc ttcaacctgc     6000

tggtgaccct taggattgac aaggcgatag gccctgggaa gatcatcgac aatacagagc     6060

aacttcctga ggcaacattt atggtccaca tcgggaactt caggagaaag aagagtgaag     6120

tctactctgc cgattattgc aaaatgaaaa tcgaaaagat gggcctggtt tttgcacttg     6180

gtgggatagg gggcaccagt cttcacatta gaagcacagg caaaatgagc aagactctcc     6240

atgcacaact cgggttcaag aagaccttat gttacccgct gatggatatc aatgaagacc     6300

ttaatcgatt actctggagg agcagatgca agatagtaag aatccaggca gttttgcagc     6360

catcagttcc tcaagaattc cgcatttacg acgacgtgat cataaatgat gaccaaggac     6420

tattcaaagt tctgtagacc gtagtgccca gcaatgcccg aaaacgaccc ccctcacaat     6480

gacagccaga aggcccggac aaaaaagccc cctccgaaag actccacgga ccaagcgaga     6540

ggccagccag cagccgacgg caagcgcgaa caccaggcgg ccccagcaca gaacagccct     6600

gacacaaggc caccaccagc caccccaatc tgcatcctcc tcgtgggacc cccgaggacc     6660

aacccccaag gctgcccccg atccaaacca ccaaccgcat ccccaccacc cccgggaaag     6720

aaacccccag caattggaag gcccctcccc ctcttcctca acacaagaac tccacaaccg     6780

aaccgcacaa gcgaccgagg tgacccaacc gcaggcatcc gactccctag acagatcctc     6840

tctccccggc aaactaaaca aaacttaggg ccaaggaaca tacacaccca acagaaccca     6900

gaccccggcc cacggcgccg cgcccccaac ccccgacaac cagagggagc ccccaaccaa     6960

tcccgccggc tcccccggtg cccacaggca gggacaccaa cccccgaaca gacccagcac     7020

ccaaccatcg acaatccaag acgggggggc ccccccaaaa aaaggccccc aggggccgac     7080

agccagcacc gcgaggaagc ccacccaccc cacacacgac cacggcaacc aaaccagaac     7140

ccagaccacc ctgggccacc agctcccaga ctcggccatc accccgcaga aaggaaaggc     7200

cacaacccgc gcaccccagc cccgatccgg cggggagcca cccaacccga accagcaccc     7260

aagagcgatc cccgaaggac ccccgaaccg caaaggacat cagtatccca cagcctctcc     7320

aagtcccccg gtctcctcct cttctcgaag ggaccaaaag atcaatccac cacacccgac     7380

gacactcaac tccccacccc taaaggagac accgggaatc ccagaatcaa gactcatcca     7440

atgtccatca tgggtctcaa ggtgaacgtc tctgccatat tcatggcagt actgttaact     7500

ctccaaacac ccaccggtca aatccattgg ggcaatctct ctaagatagg ggtggtagga     7560

ataggaagtg caagctacaa agttatgact cgttccagcc atcaatcatt agtcataaaa     7620

ttaatgccca atataactct cctcaataac tgcacgaggg tagagattgc agaatacagg     7680

agactactga gaacagtttt ggaaccaatt agagatgcac ttaatgcaat gacccagaat     7740

ataagaccgg ttcagagtgt agcttcaagt aggagacaca agagatttgc gggagtagtc     7800

ctggcaggtg cggccctagg cgttgccaca gctgctcaga taacagccgg cattgcactt     7860

caccagtcca tgctgaactc tcaagccatc gacaatctga gagcgagcct ggaaactact     7920

aatcaggcaa ttgagacaat cagacaagca gggcaggaga tgatattggc tgttcagggt     7980

gtccaagact acatcaataa tgagctgata ccgtctatga accaactatc ttgtgattta     8040

atcggccaga agctcgggct caaattgctc agatactata cagaaatcct gtcattattt     8100

ggccccagtt tacgggaccc catatctgcg gagatatcta tccaggcttt gagctatgcg     8160

cttggaggag acatcaataa ggtgttagaa aagctcggat acagtggagg tgatttactg     8220

ggcatcttag agagcggagg aataaaggcc cggataactc acgtcgacac agagtcctac     8280

ttcattgtcc tcagtatagc ctatccgacg ctgtccgaga ttaagggggt gattgtccac     8340

cggctagagg gggtctcgta caacataggc tctcaagagt ggtataccac tgtgcccaag     8400

tatgttgcaa cccaagggta ccttatctcg aattttgatg agtcatcgtg tactttcatg     8460

ccagagggga ctgtgtgcag ccaaaatgcc ttgtacccga tgagtcctct gctccaagaa     8520

tgcctccggg ggtacaccaa gtcctgtgct cgtacactcg tatccgggtc ttttgggaac     8580

cggttcattt tatcacaagg gaacctaata gccaattgtg catcaatcct ttgcaagtgt     8640

tacacaacag gaacgatcat taatcaagac cctgacaaga tcctaacata cattgctgcc     8700

gatcactgcc cggtagtcga ggtgaacggc gtgaccatcc aagtcgggag caggaggtat     8760

ccagacgctg tgtacttgca cagaattgac ctcggtcctc ccatatcatt ggagaggttg     8820

gacgtaggga caaatctggg gaatgcaatt gctaagttgg aggatgccaa ggaattgttg     8880

gagtcatcgg accagatatt gaggagtatg aaaggtttat cgagcactag catagtctac     8940

atcctgattg cagtgtgtct tggagggttg atagggatcc ccgctttaat atgttgctgc     9000

agggggcgtt gtaacaaaaa gggagaacaa gttggtatgt caagaccagg cctaaagcct     9060

gatcttacgg gaacatcaaa atcctatgta aggtcgctct gatcctctac aactcttgaa     9120

acacaaatgt cccacaagtc tcctcttcgt catcaagcaa ccaccgcacc cagcatcaag     9180

cccacctgaa attatctccg gcttccctct ggccgaacaa tatcggtagt taatcaaaac     9240

ttagggtgca agatcatcca caatgtcacc acaacgagac cggataaatg ccttctacaa     9300

agataacccc catcccaagg gaagtaggat agtcattaac agagaacatc ttatgattga     9360

tagaccttat gttttgctgg ctgttctgtt tgtcatgttt ctgagcttga tcgggttgct     9420

agccattgca ggcattagac ttcatcgggc agccatctac accgcagaga tccataaaag     9480

cctcagcacc aatctagatg taactaactc aatcgagcat caggtcaagg acgtgctgac     9540

accactcttc aaaatcatcg gtgatgaagt gggcctgagg acacctcaga gattcactga     9600

cctagtgaaa ttaatctctg acaagattaa attccttaat ccggataggg agtacgactt     9660

cagagatctc acttggtgta tcaacccgcc agagagaatc aaattggatt atgatcaata     9720

ctgtgcagat gtggctgctg aagagctcat gaatgcattg gtgaactcaa ctctactgga     9780

gaccagaaca accaatcagt tcctagctgt ctcaaaggga aactgctcag ggcccactac     9840

aatcagaggt caattctcaa acatgtcgct gtccctgtta gacttgtatt taggtcgagg     9900

ttacaatgtg tcatctatag tcactatgac atcccaggga atgtatgggg gaacttacct     9960

agtggaaaag cctaatctga gcagcaaaag gtcagagttg tcacaactga gcatgtaccg    10020

agtgtttgaa gtaggtgtta tcagaaatcc gggtttgggg gctccggtgt tccatatgac    10080

aaactatctt gagcaaccag tcagtaatga tctcagcaac tgtatggtgg ctttggggga    10140

gctcaaactc gcagcccttt gtcacgggga agattctatc acaattccct atcagggatc    10200

agggaaaggt gtcagcttcc agctcgtcaa gctaggtgtc tggaaatccc caaccgacat    10260

gcaatcctgg gtccccttat caacggatga tccagtgata gacaggcttt acctctcatc    10320

tcacagaggt gttatcgctg acaatcaagc aaaatgggct gtcccgacaa cacgaacaga    10380

tgacaagttg cgaatggaga catgcttcca acaggcgtgt aagggtaaaa tccaagcact    10440

ctgcgagaat cccgagtggg caccattgaa ggataacagg attccttcat acggggtctt    10500

gtctgttgat ctgagtctga cagttgagct taaaatcaaa attgcttcgg gattcgggcc    10560

attgatcaca cacggttcag ggatggacct atacaaatcc aaccacaaca atgtgtattg    10620

gctgactatc ccgccaatga agaacctagc cttaggtgta atcaacacat tggagtggat    10680

accgagattc aaggttagtc cctacctctt cactgtccca attaaggaag caggcgaaga    10740

ctgccatgcc ccaacatacc tacctgcgga ggtggatggt gatgtcaaac tcagttccaa    10800

tctggtgatt ctacctggtc aagatctcca atatgttttg gcaacctacg atacttccag    10860

ggttgaacat gctgtggttt attacgttta cagcccaagc cgctcatttt cttactttta    10920

tccttttagg ttgcctataa agggggtccc catcgaatta caagtggaat gcttcacatg    10980

ggaccaaaaa ctctggtgcc gtcacttctg tgtgcttgcg gactcagaat ctggtggaca    11040

tatcactcac tctgggatgg tgggcatggg agtcagctgc acagtcaccc gggaagatgg    11100

aaccaatcgc agatagggct gctagtgaac caatcacatg atgtcaccca gacatcaggc    11160

atacccacta gtgtgaaata gacatcagaa ttaagaaaaa cgtagggtcc aagtggttcc    11220

ccgttatgga ctcgctatct gtcaaccaga tcttataccc tgaagttcac ctagatagcc    11280

cgatagttac caataagata gtagccatcc tggagtatgc tcgagtccct cacgcttaca    11340

gcctggagga ccctacactg tgtcagaaca tcaagcaccg cctaaaaaac ggattttcca    11400

accaaatgat tataaacaat gtggaagttg ggaatgtcat caagtccaag cttaggagtt    11460

atccggccca ctctcatatt ccatatccaa attgtaatca ggatttattt aacatagaag    11520

acaaagagtc aacgaggaag atccgtgaac tcctcaaaaa ggggaattcg ctgtactcca    11580

aagtcagtga taaggttttc caatgcttaa gggacactaa ctcacggctt ggcctaggct    11640

ccgaattgag ggaggacatc aaggagaaag ttattaactt gggagtttac atgcacagct    11700

cccagtggtt tgagcccttt ctgttttggt ttacagtcaa gactgagatg aggtcagtga    11760

ttaaatcaca aacccatact tgccatagga ggagacacac acctgtattc ttcactggta    11820

gttcagttga gttgctaatc tctcgtgacc ttgttgctat aatcagtaaa gagtctcaac    11880

atgtatatta cctgacattt gaactggttt tgatgtattg tgatgtcata gaggggaggt    11940

taatgacaga gaccgctatg actattgatg ctaggtatac agagcttcta ggaagagtca    12000

gatacatgtg gaaactgata gatggtttct tccctgcact cgggaatcca acttatcaaa    12060

ttgtagccat gctggagcct ctttcacttg cttacctgca gctgagggat ataacagtag    12120

aactcagagg tgctttcctt aaccactgct ttactgaaat acatgatgtt cttgaccaaa    12180

acgggttttc tgatgaaggt acttatcatg agttaactga agctctagat tacattttca    12240

taactgatga catacatctg acaggggaga ttttctcatt tttcagaagt ttcggccacc    12300

ccagacttga agcagtaacg gctgctgaaa atgttaggaa atacatgaat cagcctaaag    12360

tcattgtgta tgagactctg atgaaaggtc atgccatatt ttgtggaatc ataatcaacg    12420

gctatcgtga caggcacgga ggcagttggc caccgctgac cctccccctg catgctgcag    12480

acacaatccg gaatgctcaa gcttcaggtg aagggttaac acatgagcag tgcgttgata    12540

actggaaatc ttttgctgga gtgaaatttg gctgctttat gcctcttagc ctggatagtg    12600

atctgacaat gtacctaaag gacaaggcac ttgctgctct ccaaagggaa tgggattcag    12660

tttacccgaa agagttcctg cgttacgacc ctcccaaggg aaccgggtca cggaggcttg    12720

tagatgtttt ccttaatgat tcgagctttg acccatatga tgtgataatg tatgttgtaa    12780

gtggagctta cctccatgac cctgagttca acctgtctta cagcctgaaa gaaaaggaga    12840

tcaaggaaac aggtagactt tttgctaaaa tgacttacaa aatgagggca tgccaagtga    12900

ttgctgaaaa tctaatctca aacgggattg gcaaatattt taaggacaat gggatggcca    12960

aggatgagca cgatttgact aaggcactcc acactctagc tgtctcagga gtccccaaag    13020

atctcaaaga aagtcacagg ggggggccag tcttaaaaac ctactcccga agcccagtcc    13080

acacaagtac caggaacgtg agagcagcaa aagggtttat agggttccct caagtaattc    13140

ggcaggacca agacactgat catccggaga atatggaagc ttacgagaca gtcagtgcat    13200

ttatcacgac tgatctcaag aagtactgcc ttaattggag atatgagacc atcagcttgt    13260

ttgcacagag gctaaatgag atttacggat tgccctcatt tttccagtgg ctgcataaga    13320

ggcttgagac ctctgtcctg tatgtaagtg accctcattg cccccccgac cttgacgccc    13380

atatcccgtt atataaagtc cccaatgatc aaatcttcat taagtaccct atgggaggta    13440

tagaagggta ttgtcagaag ctgtggacca tcagcaccat tccctatcta tacctggctg    13500

cttatgagag cggagtaagg attgcttcgt tagtgcaagg ggacaatcag accatagccg    13560

taacaaaaag ggtacccagc acatggccct acaaccttaa gaaacgggaa gctgctagag    13620

taactagaga ttactttgta attcttaggc aaaggctaca tgatattggc catcacctca    13680

aggcaaatga gacaattgtt tcatcacatt tttttgtcta ttcaaaagga atatattatg    13740

atgggctact tgtgtcccaa tcactcaaga gcatcgcaag atgtgtattc tggtcagaga    13800

ctatagttga tgaaacaagg gcagcatgca gtaatattgc tacaacaatg gctaaaagca    13860

tcgagagagg ttatgaccgt taccttgcat attccctgaa cgtcctaaaa gtgatacagc    13920

aaattctgat ctctcttggc ttcacaatca attcaaccat gacccgggat gtagtcatac    13980

ccctcctcac aaacaacgac ctcttaataa ggatggcact gttgcccgct cctattgggg    14040

ggatgaatta tctgaatatg agcaggctgt ttgtcagaaa catcggtgat ccagtaacat    14100

catcaattgc tgatctcaag agaatgattc tcgcctcact aatgcctgaa gagaccctcc    14160

atcaagtaat gacacaacaa ccgggggact cttcattcct agactgggct agcgaccctt    14220

actcagcaaa tcttgtatgt gtccagagca tcactagact cctcaagaac ataactgcaa    14280

ggtttgtcct gatccatagt ccaaacccaa tgttaaaagg attattccat gatgacagta    14340

aagaagagga cgagggactg gcggcattcc tcatggacag gcatattata gtacctaggg    14400

cagctcatga aatcctggat catagtgtca caggggcaag agagtctatt gcaggcatgc    14460

tggataccac aaaaggcttg attcgagcca gcatgaggaa gggggggtta acctctcgag    14520

tgataaccag attgtccaat tatgactatg aacaattcag agcagggatg gtgctattga    14580

caggaagaaa gagaaatgtc ctcattgaca aagagtcatg ttcagtgcag ctggcgagag    14640

ctctaagaag ccatatgtgg gcgaggctag ctcgaggacg gcctatttac ggccttgagg    14700

tccctgatgt actagaatct atgcgaggcc accttattcg gcgtcatgag acatgtgtca    14760

tctgcgagtg tggatcagtc aactacggat ggttttttgt cccctcgggt tgccaactgg    14820

atgatattga caaggaaaca tcatccttga gagtcccata tattggttct accactgatg    14880

agagaacaga catgaagctt gccttcgtaa gagccccaag tcgatccttg cgatctgctg    14940

ttagaatagc aacagtgtac tcatgggctt acggtgatga tgatagctct tggaacgaag    15000

cctggttgtt ggctaggcaa agggccaatg tgagcctgga ggagctaagg gtgatcactc    15060

ccatctcaac ttcgactaat ttagcgcata ggttgaggga tcgtagcact caagtgaaat    15120

actcaggtac atcccttgtc cgagtggcga ggtataccac aatctccaac gacaatctct    15180

catttgtcat atcagataag aaggttgata ctaactttat ataccaacaa ggaatgcttc    15240

tagggttggg tgttttagaa acattgtttc gactcgagaa agataccgga tcatctaaca    15300

cggtattaca tcttcacgtc gaaacagatt gttgcgtgat cccgatgata gatcatccca    15360

ggatacccag ctcccgcaag ctagagctga gggcagagct atgtaccaac ccattgatat    15420

atgataatgc acctttaatt gacagagatg caacaaggct atacacccag agccatagga    15480

ggcaccttgt ggaatttgtt acatggtcca caccccaact atatcacatt ttagctaagt    15540

ccacagcact atctatgatt gacctggtaa caaaatttga gaaggaccat atgaatgaaa    15600

tttcagctct cataggggat gacgatatca atagtttcat aactgagttt ctgctcatag    15660

agccaagatt attcactatc tacttgggcc agtgtgcggc catcaattgg gcatttgatg    15720

tacattatca tagaccatca gggaaatatc agatgggtga gctgttgtca tcgttccttt    15780

ctagaatgag caaaggagtg tttaaggtgc ttgtcaatgc tctaagccac ccaaagatct    15840

acaagaaatt ctggcattgt ggtattatag agcctatcca tggtccttca cttgatgctc    15900

aaaacttgca cacaactgtg tgcaacatgg tttacacatg ctatatgacc tacctcgacc    15960

tgttgttgaa tgaagagtta gaagagttca catttctctt gtgtgaaagc gacgaggatg    16020

tagtaccgga cagattcgac aacatccagg caaaacactt atgtgttctg gcagatttgt    16080

actgtcaacc agggacctgc ccaccaattc gaggtctaag accggtagag aaatgtgcag    16140

ttctaaccga ccatatcaag gcagaggcta tgttatctcc agcaggatct tcgtggaaca    16200

taaatccaat tattgtagac cattactcat gctctctgac ttatctccgg cgaggatcga    16260

tcaaacagat aagattgaga gttgatccag gattcatttt cgacgccctc gctgaggtaa    16320

atgtcagtca gccaaagatc ggcagcaaca acatctcaaa tatgagcatc aaggctttca    16380

gacccccaca cgatgatgtt gcaaaattgc tcaaagatat caacacaagc aagcacaatc    16440

ttcccatttc agggggcaat ctcgccaatt atgaaatcca tgctttccgc agaatcgggt    16500

tgaactcatc tgcttgctac aaagctgttg agatatcaac attaattagg agatgccttg    16560

agccagggga ggacggcttg ttcttgggtg agggatcggg ttctatgttg atcacttata    16620

aagagatact taaactaaac aagtgcttct ataatagtgg ggtttccgcc aattctagat    16680

ctggtcaaag ggaattagca ccctatccct ccgaagttgg ccttgtcgaa cacagaatgg    16740

gagtaggtaa tattgtcaaa gtgctcttta acgggaggcc cgaagtcacg tgggtaggca    16800

gtgtagattg cttcaatttc atagttagta atatccctac ctctagtgtg gggtttatcc    16860

attcagatat agagaccttg cctgacaaag atactataga gaagctagag gaattggcag    16920

ccatcttatc gatggctctg ctcctgggca aaataggatc aatactggtg attaagctta    16980

tgcctttcag cggggatttt gttcagggat ttataagtta tgtagggtct cattatagag    17040

aagtgaacct tgtataccct agatacagca acttcatctc tactgaatct tatttggtta    17100

tgacagatct caaggctaac cggctaatga atcctgaaaa gattaagcag cagataattg    17160

aatcatctgt gaggacttca cctggactta taggtcacat cctatccatt aagcaactaa    17220

gctgcataca agcaattgtg ggagacgcag ttagtagagg tgatatcaat cctactctga    17280

aaaaacttac acctatagag caggtgctga tcaattgcgg gttggcaatt aacggaccta    17340

agctgtgcaa agaattgatc caccatgatg ttgcctcagg gcaagatgga ttgcttaatt    17400

ctatactcat cctctacagg gagttggcaa gattcaaaga caaccaaaga agtcaacaag    17460

ggatgttcca cgcttacccc gtattggtaa gtagcaggca acgagaactt atatctagga    17520

tcacccgcaa attctggggg cacattcttc tttactccgg gaacaaaaag ttgataaata    17580

agtttatcca gaatctcaag tccggctatc tgatactaga cttacaccag aatatcttcg    17640

ttaagaatct atccaagtca gagaaacaga ttattatgac ggggggtttg aaacgtgagt    17700

gggtttttaa ggtaacagtc aaggagacca aagaatggta taagttagtc ggatacagtg    17760

ccctgattaa ggactaattg gttgaactcc ggaaccctaa tcctgcccta ggtggttagg    17820

cattatttgc aatatattaa agaaaacttt gaaaatacga agtttctatt cccagctttg    17880

tctggtggcc ggcatggtcc cagcctcctc gctggcgccg gctgggcaac attccgaggg    17940

gaccgtcccc tcggtaatgg cgaatgggac gcggccgatc cggctgctaa caaagcccga    18000

aaggaagctg agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc    18060

tctaaacggg tcttgagggg ttttttgctg aaaggaggaa ctatatccgg atgcggccgc    18120

gggccctatg gtacccagct tttgttccct ttagtgaggg ttaattccga gcttggcgta    18180

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat    18240

aggagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgaggt aactcacatt    18300

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta    18360

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc    18420

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa    18480

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa    18540

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct    18600

cggcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac    18660

aggactataa agataccagg cgttcccccc tggaagctcc ctcgtgcgct ctcctgttcc    18720

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc    18780

tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg    18840

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga    18900

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag    18960

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta    19020

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag    19080

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg    19140

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac    19200

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc    19260

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag    19320

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc    19380

agcgatctgt ctatttcgtt catccatagt tgcctgactg cccgtcgtgt agataactac    19440

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc    19500

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg    19560

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag    19620

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc    19680

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac    19740

atgatccccc atgttgtgaa aaaaagcggt tagctccttc ggtcctccga tcgttgtcag    19800

aagtaagttg gccgcagtgt tatcactcat gcttatggca gcactgcata attctcttac    19860

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg    19920

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc    19980

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact    20040

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg    20100

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa    20160

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt    20220

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg    20280

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga    20340

aattgtaaac gttaatattt tgttaaaatt cgcgttaaat ttttgttaaa tcagctcatt    20400

ttttaaccaa taggccgaaa tcggcaaaat cccttataaa tcaaaagaat agaccgagat    20460

agggttgagt gttgttccag tttggaacaa gagtccacta ttaaagaacg tggactccaa    20520

cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca ctacgtgaac catcacccta    20580

atcaagtttt ttggggtcga ggtgccgtaa agcactaaat cggaacccta aagggagccc    20640

ccgatttaga gcttgacggg gaaagccggc gaacgtggcg agaaaggaag ggaagaaagc    20700

gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc acgctgcgcg taaccaccac    20760

acccgccgcg cttaatgcgc cgctacaggg cgcgtcccat tcgccattca ggctgcgcaa    20820

ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccagccac cgcggtgatc    20880

cttataaagc tagatg                                                    20896


<210>  58
<211>  21196
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MV Zika RSP codon optimization (human) L107D

<400>  58
tcatgaacgc ggccgctaat acgactcact atagggccaa ctttgtttgg tctgatgagt       60

ccgtgaggac gaaacccgga gtcccgggtc accaaacaaa gttgggtaag gatagttcaa      120

tcaatgatca tcttctagtg cacttaggat tcaagatcct attatcaggg acaagagcag      180

gattagggat atccgagatg gccacacttt taaggagctt agcattgttc aaaagaaaca      240

aggacaaacc acccattaca tcaggatccg gtggagccat cagaggaatc aaacacatta      300

ttatagtacc aatccctgga gattcctcaa ttaccactcg atccagactt ctggaccggt      360

tggtgaggtt aattggaaac ccggatgtga gcgggcccaa actaacaggg gcactaatag      420

gtatattatc cttatttgtg gagtctccag gtcaattgat tcagaggatc accgatgacc      480

ctgacgttag cataaggctg ttagaggttg tccagagtga ccagtcacaa tctggcctta      540

ccttcgcatc aagaggtacc aacatggagg atgaggcgga ccaatacttt tcacatgatg      600

atccaattag tagtgatcaa tccaggttcg gatggttcgg gaacaaggaa atctcagata      660

ttgaagtgca agaccctgag ggattcaaca tgattctggg taccatccta gcccaaattt      720

gggtcttgct cgcaaaggcg gttacggccc cagacacggc agctgattcg gagctaagaa      780

ggtggataaa gtacacccaa caaagaaggg tagttggtga atttagattg gagagaaaat      840

ggttggatgt ggtgaggaac aggattgccg aggacctctc cttacgccga ttcatggtcg      900

ctctaatcct ggatatcaag agaacacccg gaaacaaacc caggattgct gaaatgatat      960

gtgacattga tacatatatc gtagaggcag gattagccag ttttatcctg actattaagt     1020

ttgggataga aactatgtat cctgctcttg gactgcatga atttgctggt gagttatcca     1080

cacttgagtc cttgatgaac ctttaccagc aaatggggga aactgcaccc tacatggtaa     1140

tcctggagaa ctcaattcag aacaagttca gtgcaggatc ataccctctg ctctggagct     1200

atgccatggg agtaggagtg gaacttgaaa actccatggg aggtttgaac tttggccgat     1260

cttactttga tccagcatat tttagattag ggcaagagat ggtaaggagg tcagctggaa     1320

aggtcagttc cacattggca tctgaactcg gtatcactgc cgaggatgca aggcttgttt     1380

cagagattgc aatgcatact actgaggaca agatcagtag agcggttgga cccagacaag     1440

cccaagtatc atttctacac ggtgatcaaa gtgagaatga gctaccgaga ttggggggca     1500

aggaagatag gagggtcaaa cagagtcgag gagaagccag ggagagctac agagaaaccg     1560

ggcccagcag agcaagtgat gcgagagctg cccatcttcc aaccggcaca cccctagaca     1620

ttgacactgc aacggagtcc agccaagatc cgcaggacag tcgaaggtca gctgacgccc     1680

tgcttaggct gcaagccatg gcaggaatct cggaagaaca aggctcagac acggacaccc     1740

ctatagtgta caatgacaga aatcttctag actaggtgcg agaggccgag ggccagaaca     1800

acatccgcct accatccatc attgttataa aaaacttagg aaccaggtcc acacagccgc     1860

cagcccatca accatccact cccacgattg gagccaatgg cagaagagca ggcacgccat     1920

gtcaaaaacg gactggaatg catccgggct ctcaaggccg agcccatcgg ctcactggcc     1980

atcgaggaag ctatggcagc atggtcagaa atatcagaca acccaggaca ggagcgagcc     2040

acctgcaggg aagagaaggc aggcagttcg ggtctcagca aaccatgcct ctcagcaatt     2100

ggatcaactg aaggcggtgc acctcgcatc cgcggtcagg gacctggaga gagcgatgac     2160

gacgctgaaa ctttgggaat ccccccaaga aatctccagg catcaagcac tgggttacag     2220

tgttattacg tttatgatca cagcggtgaa gcggttaagg gaatccaaga tgctgactct     2280

atcatggttc aatcaggcct tgatggtgat agcaccctct caggaggaga caatgaatct     2340

gaaaacagcg atgtggatat tggcgaacct gataccgagg gatatgctat cactgaccgg     2400

ggatctgctc ccatctctat ggggttcagg gcttctgatg ttgaaactgc agaaggaggg     2460

gagatccacg agctcctgag actccaatcc agaggcaaca actttccgaa gcttgggaaa     2520

actctcaatg ttcctccgcc cccggacccc ggtagggcca gcacttccgg gacacccatt     2580

aaaaagggca cagacgcgag attagcctca tttggaacgg agatcgcgtc tttattgaca     2640

ggtggtgcaa cccaatgtgc tcgaaagtca ccctcggaac catcagggcc aggtgcacct     2700

gcggggaatg tccccgagtg tgtgagcaat gccgcactga tacaggagtg gacacccgaa     2760

tctggtacca caatctcccc gagatcccag aataatgaag aagggggaga ctattatgat     2820

gatgagctgt tctctgatgt ccaagatatt aaaacagcct tggccaaaat acacgaggat     2880

aatcagaaga taatctccaa gctagaatca ctgctgttat tgaagggaga agttgagtca     2940

attaagaagc agatcaacag gcaaaatatc agcatatcca ccctggaagg acacctctca     3000

agcatcatga tcgccattcc tggacttggg aaggatccca acgaccccac tgcagatgtc     3060

gaaatcaatc ccgacttgaa acccatcata ggcagagatt caggccgagc actggccgaa     3120

gttctcaaga aacccgttgc cagccgacaa ctccaaggaa tgacaaatgg acggaccagt     3180

tccagaggac agctgctgaa ggaatttcag ctaaagccga tcgggaaaaa gatgagctca     3240

gccgtcgggt ttgttcctga caccggccct gcatcacgca gtgtaatccg ctccattata     3300

aaatccagcc ggctagagga ggatcggaag cgttacctga tgactctcct tgatgatatc     3360

aaaggagcca atgatcttgc caagttccac cagatgctga tgaagataat aatgaagtag     3420

ctacagctca acttacctgc caaccccatg ccagtcgacc caactagcct accctccatc     3480

attgttataa aaaacttagg aaccaggtcc acacagccgc cagcccatca acgcgtacgg     3540

ccaccatggc acgcagaggc gctgatacct cagttggtat agtgggattg ctgttgacaa     3600

ccgccatggc cgcagaagtg acgagaaggg gttctgccta ctatatgtac cttgatcgga     3660

atgacgctgg agaggcaatc tcattcccga ccaccttggg catgaacaaa tgctacatcc     3720

agattatgga cctgggacat atgtgcgatg ccactatgag ctatgagtgc cccatgctgg     3780

atgagggagt agagcctgac gatgttgact gctggtgtaa caccactagt acatgggtgg     3840

tgtacggaac gtgccaccac aagaaaggag aagctcgaag atcccgtcgc gcggttactc     3900

ttccctccca ttccacaagg aaactccaaa cccgtagcca gacatggctt gaaagccgag     3960

aatacactaa acacttgata cgggtagaga actggatttt ccgcaatccc gggtttgctc     4020

ttgcagctgc ggcaattgct tggctcctcg ggtcaagcac atcccagaag gtgatctacc     4080

tggtgatgat cctgctgatt gcaccagcct attcaatccg gtgtatcggt gtctcaaatc     4140

gtgacttcgt cgaggggatg agtggcggga cctgggtgga tgtcgttctg gaacatggag     4200

gctgtgtaac ggtgatggct caagacaagc caaccgttga catcgaactg gtaacgacga     4260

cagtcagcaa tatggccgaa gtccgctctt actgctatga agccagcatc agcgatatgg     4320

ccagcgatag tcgatgtccg actcaaggcg aagcctatct cgacaaacag tctgacaccc     4380

agtacgtgtg caagaggact ctcgtggata gagggtgggg caatggttgt ggggatttcg     4440

gcaaggggtc actggtaacc tgtgcaaagt tcgcctgctc taagaagatg actgggaaga     4500

gtatccagcc cgagaatctg gagtatagga tcatgctgag cgttcatgga tcccagcata     4560

gcgggatgat cgtgaatgat acgggtcacg aaacagacga gaaccgcgca aaggtcgaga     4620

ttactcccaa ttcccctagg gccgaagcca cactcggagg ctttggcagt ctcggcctgg     4680

attgcgagcc tcgcactgga ctggatttct ccgacctgta ctacctgact atgaacaaca     4740

aacattggct ggtgcacaag gaatggtttc acgacattcc cctgccttgg cacgctgggg     4800

ctgacactgg tacacctcat tggaacaaca aagaggctct ggtggagttc aaagatgcac     4860

atgccaagag acaaaccgtg gtggttctgg gatcacagga aggcgccgtg cataccgcgc     4920

ttgccggagc actggaagca gagatggacg gtgctaaagg ccggttgagc tctggccacc     4980

ttaagtgtcg gctgaagatg gacaagctga gattgaaagg agtctcctat agtctgtgta     5040

cagccgcgtt tacctttacg aaaatccccg ctgagacact gcacggaaca gtgaccgtgg     5100

aggtgcaata tgcagggact gatggcccat gtaaggtgcc agcacagatg gctgttgaca     5160

tgcagactct caccccagtc ggcaggctta ttactgccaa tccggtcata accgagagta     5220

cagagaatag caagatgatg ctggagcttg accctccatt cggagactcc tacattgtca     5280

ttggcgtcgg tgagaagaag attacccacc actggcacag gtctggctcc acaatcggta     5340

aagccttcga agcgacagtg agaggagcca aacggatggc ggtactcgga gacacagcct     5400

gggatttcgg gagcgttggt ggcgctctga actctctcgg gaaaggtatc caccagatat     5460

ttggggcagc ctttaaatca ctctttggcg gcatgagctg gttttctcag atcctgattg     5520

ggaccctcct gatgtggctg gggctgaaca ccaagaacgg ctctataagc ctgatgtgct     5580

tggccctggg cggggtgttg attttcctgt ccaccgctgt gagtgcctaa tgagcgcgca     5640

gcgcttagac gtctcgcgat cgatactagt acaacctaaa tccattataa aaaacttagg     5700

agcaaagtga ttgcctccca aggtccacaa tgacagagac ctacgacttc gacaagtcgg     5760

catgggacat caaagggtcg atcgctccga tacaacccac cacctacagt gatggcaggc     5820

tggtgcccca ggtcagagtc atagatcctg gtctaggcga caggaaggat gaatgcttta     5880

tgtacatgtt tctgctgggg gttgttgagg acagcgattc cctagggcct ccaatcgggc     5940

gagcatttgg gttcctgccc ttaggtgttg gcagatccac agcaaagccc gaaaaactcc     6000

tcaaagaggc cactgagctt gacatagttg ttagacgtac agcagggctc aatgaaaaac     6060

tggtgttcta caacaacacc ccactaactc tcctcacacc ttggagaaag gtcctaacaa     6120

cagggagtgt cttcaacgca aaccaagtgt gcaatgcggt taatctgata ccgctcgata     6180

ccccgcagag gttccgtgtt gtttatatga gcatcacccg tctttcggat aacgggtatt     6240

acaccgttcc tagaagaatg ctggaattca gatcggtcaa tgcagtggcc ttcaacctgc     6300

tggtgaccct taggattgac aaggcgatag gccctgggaa gatcatcgac aatacagagc     6360

aacttcctga ggcaacattt atggtccaca tcgggaactt caggagaaag aagagtgaag     6420

tctactctgc cgattattgc aaaatgaaaa tcgaaaagat gggcctggtt tttgcacttg     6480

gtgggatagg gggcaccagt cttcacatta gaagcacagg caaaatgagc aagactctcc     6540

atgcacaact cgggttcaag aagaccttat gttacccgct gatggatatc aatgaagacc     6600

ttaatcgatt actctggagg agcagatgca agatagtaag aatccaggca gttttgcagc     6660

catcagttcc tcaagaattc cgcatttacg acgacgtgat cataaatgat gaccaaggac     6720

tattcaaagt tctgtagacc gtagtgccca gcaatgcccg aaaacgaccc ccctcacaat     6780

gacagccaga aggcccggac aaaaaagccc cctccgaaag actccacgga ccaagcgaga     6840

ggccagccag cagccgacgg caagcgcgaa caccaggcgg ccccagcaca gaacagccct     6900

gacacaaggc caccaccagc caccccaatc tgcatcctcc tcgtgggacc cccgaggacc     6960

aacccccaag gctgcccccg atccaaacca ccaaccgcat ccccaccacc cccgggaaag     7020

aaacccccag caattggaag gcccctcccc ctcttcctca acacaagaac tccacaaccg     7080

aaccgcacaa gcgaccgagg tgacccaacc gcaggcatcc gactccctag acagatcctc     7140

tctccccggc aaactaaaca aaacttaggg ccaaggaaca tacacaccca acagaaccca     7200

gaccccggcc cacggcgccg cgcccccaac ccccgacaac cagagggagc ccccaaccaa     7260

tcccgccggc tcccccggtg cccacaggca gggacaccaa cccccgaaca gacccagcac     7320

ccaaccatcg acaatccaag acgggggggc ccccccaaaa aaaggccccc aggggccgac     7380

agccagcacc gcgaggaagc ccacccaccc cacacacgac cacggcaacc aaaccagaac     7440

ccagaccacc ctgggccacc agctcccaga ctcggccatc accccgcaga aaggaaaggc     7500

cacaacccgc gcaccccagc cccgatccgg cggggagcca cccaacccga accagcaccc     7560

aagagcgatc cccgaaggac ccccgaaccg caaaggacat cagtatccca cagcctctcc     7620

aagtcccccg gtctcctcct cttctcgaag ggaccaaaag atcaatccac cacacccgac     7680

gacactcaac tccccacccc taaaggagac accgggaatc ccagaatcaa gactcatcca     7740

atgtccatca tgggtctcaa ggtgaacgtc tctgccatat tcatggcagt actgttaact     7800

ctccaaacac ccaccggtca aatccattgg ggcaatctct ctaagatagg ggtggtagga     7860

ataggaagtg caagctacaa agttatgact cgttccagcc atcaatcatt agtcataaaa     7920

ttaatgccca atataactct cctcaataac tgcacgaggg tagagattgc agaatacagg     7980

agactactga gaacagtttt ggaaccaatt agagatgcac ttaatgcaat gacccagaat     8040

ataagaccgg ttcagagtgt agcttcaagt aggagacaca agagatttgc gggagtagtc     8100

ctggcaggtg cggccctagg cgttgccaca gctgctcaga taacagccgg cattgcactt     8160

caccagtcca tgctgaactc tcaagccatc gacaatctga gagcgagcct ggaaactact     8220

aatcaggcaa ttgagacaat cagacaagca gggcaggaga tgatattggc tgttcagggt     8280

gtccaagact acatcaataa tgagctgata ccgtctatga accaactatc ttgtgattta     8340

atcggccaga agctcgggct caaattgctc agatactata cagaaatcct gtcattattt     8400

ggccccagtt tacgggaccc catatctgcg gagatatcta tccaggcttt gagctatgcg     8460

cttggaggag acatcaataa ggtgttagaa aagctcggat acagtggagg tgatttactg     8520

ggcatcttag agagcggagg aataaaggcc cggataactc acgtcgacac agagtcctac     8580

ttcattgtcc tcagtatagc ctatccgacg ctgtccgaga ttaagggggt gattgtccac     8640

cggctagagg gggtctcgta caacataggc tctcaagagt ggtataccac tgtgcccaag     8700

tatgttgcaa cccaagggta ccttatctcg aattttgatg agtcatcgtg tactttcatg     8760

ccagagggga ctgtgtgcag ccaaaatgcc ttgtacccga tgagtcctct gctccaagaa     8820

tgcctccggg ggtacaccaa gtcctgtgct cgtacactcg tatccgggtc ttttgggaac     8880

cggttcattt tatcacaagg gaacctaata gccaattgtg catcaatcct ttgcaagtgt     8940

tacacaacag gaacgatcat taatcaagac cctgacaaga tcctaacata cattgctgcc     9000

gatcactgcc cggtagtcga ggtgaacggc gtgaccatcc aagtcgggag caggaggtat     9060

ccagacgctg tgtacttgca cagaattgac ctcggtcctc ccatatcatt ggagaggttg     9120

gacgtaggga caaatctggg gaatgcaatt gctaagttgg aggatgccaa ggaattgttg     9180

gagtcatcgg accagatatt gaggagtatg aaaggtttat cgagcactag catagtctac     9240

atcctgattg cagtgtgtct tggagggttg atagggatcc ccgctttaat atgttgctgc     9300

agggggcgtt gtaacaaaaa gggagaacaa gttggtatgt caagaccagg cctaaagcct     9360

gatcttacgg gaacatcaaa atcctatgta aggtcgctct gatcctctac aactcttgaa     9420

acacaaatgt cccacaagtc tcctcttcgt catcaagcaa ccaccgcacc cagcatcaag     9480

cccacctgaa attatctccg gcttccctct ggccgaacaa tatcggtagt taatcaaaac     9540

ttagggtgca agatcatcca caatgtcacc acaacgagac cggataaatg ccttctacaa     9600

agataacccc catcccaagg gaagtaggat agtcattaac agagaacatc ttatgattga     9660

tagaccttat gttttgctgg ctgttctgtt tgtcatgttt ctgagcttga tcgggttgct     9720

agccattgca ggcattagac ttcatcgggc agccatctac accgcagaga tccataaaag     9780

cctcagcacc aatctagatg taactaactc aatcgagcat caggtcaagg acgtgctgac     9840

accactcttc aaaatcatcg gtgatgaagt gggcctgagg acacctcaga gattcactga     9900

cctagtgaaa ttaatctctg acaagattaa attccttaat ccggataggg agtacgactt     9960

cagagatctc acttggtgta tcaacccgcc agagagaatc aaattggatt atgatcaata    10020

ctgtgcagat gtggctgctg aagagctcat gaatgcattg gtgaactcaa ctctactgga    10080

gaccagaaca accaatcagt tcctagctgt ctcaaaggga aactgctcag ggcccactac    10140

aatcagaggt caattctcaa acatgtcgct gtccctgtta gacttgtatt taggtcgagg    10200

ttacaatgtg tcatctatag tcactatgac atcccaggga atgtatgggg gaacttacct    10260

agtggaaaag cctaatctga gcagcaaaag gtcagagttg tcacaactga gcatgtaccg    10320

agtgtttgaa gtaggtgtta tcagaaatcc gggtttgggg gctccggtgt tccatatgac    10380

aaactatctt gagcaaccag tcagtaatga tctcagcaac tgtatggtgg ctttggggga    10440

gctcaaactc gcagcccttt gtcacgggga agattctatc acaattccct atcagggatc    10500

agggaaaggt gtcagcttcc agctcgtcaa gctaggtgtc tggaaatccc caaccgacat    10560

gcaatcctgg gtccccttat caacggatga tccagtgata gacaggcttt acctctcatc    10620

tcacagaggt gttatcgctg acaatcaagc aaaatgggct gtcccgacaa cacgaacaga    10680

tgacaagttg cgaatggaga catgcttcca acaggcgtgt aagggtaaaa tccaagcact    10740

ctgcgagaat cccgagtggg caccattgaa ggataacagg attccttcat acggggtctt    10800

gtctgttgat ctgagtctga cagttgagct taaaatcaaa attgcttcgg gattcgggcc    10860

attgatcaca cacggttcag ggatggacct atacaaatcc aaccacaaca atgtgtattg    10920

gctgactatc ccgccaatga agaacctagc cttaggtgta atcaacacat tggagtggat    10980

accgagattc aaggttagtc cctacctctt cactgtccca attaaggaag caggcgaaga    11040

ctgccatgcc ccaacatacc tacctgcgga ggtggatggt gatgtcaaac tcagttccaa    11100

tctggtgatt ctacctggtc aagatctcca atatgttttg gcaacctacg atacttccag    11160

ggttgaacat gctgtggttt attacgttta cagcccaagc cgctcatttt cttactttta    11220

tccttttagg ttgcctataa agggggtccc catcgaatta caagtggaat gcttcacatg    11280

ggaccaaaaa ctctggtgcc gtcacttctg tgtgcttgcg gactcagaat ctggtggaca    11340

tatcactcac tctgggatgg tgggcatggg agtcagctgc acagtcaccc gggaagatgg    11400

aaccaatcgc agatagggct gctagtgaac caatcacatg atgtcaccca gacatcaggc    11460

atacccacta gtgtgaaata gacatcagaa ttaagaaaaa cgtagggtcc aagtggttcc    11520

ccgttatgga ctcgctatct gtcaaccaga tcttataccc tgaagttcac ctagatagcc    11580

cgatagttac caataagata gtagccatcc tggagtatgc tcgagtccct cacgcttaca    11640

gcctggagga ccctacactg tgtcagaaca tcaagcaccg cctaaaaaac ggattttcca    11700

accaaatgat tataaacaat gtggaagttg ggaatgtcat caagtccaag cttaggagtt    11760

atccggccca ctctcatatt ccatatccaa attgtaatca ggatttattt aacatagaag    11820

acaaagagtc aacgaggaag atccgtgaac tcctcaaaaa ggggaattcg ctgtactcca    11880

aagtcagtga taaggttttc caatgcttaa gggacactaa ctcacggctt ggcctaggct    11940

ccgaattgag ggaggacatc aaggagaaag ttattaactt gggagtttac atgcacagct    12000

cccagtggtt tgagcccttt ctgttttggt ttacagtcaa gactgagatg aggtcagtga    12060

ttaaatcaca aacccatact tgccatagga ggagacacac acctgtattc ttcactggta    12120

gttcagttga gttgctaatc tctcgtgacc ttgttgctat aatcagtaaa gagtctcaac    12180

atgtatatta cctgacattt gaactggttt tgatgtattg tgatgtcata gaggggaggt    12240

taatgacaga gaccgctatg actattgatg ctaggtatac agagcttcta ggaagagtca    12300

gatacatgtg gaaactgata gatggtttct tccctgcact cgggaatcca acttatcaaa    12360

ttgtagccat gctggagcct ctttcacttg cttacctgca gctgagggat ataacagtag    12420

aactcagagg tgctttcctt aaccactgct ttactgaaat acatgatgtt cttgaccaaa    12480

acgggttttc tgatgaaggt acttatcatg agttaactga agctctagat tacattttca    12540

taactgatga catacatctg acaggggaga ttttctcatt tttcagaagt ttcggccacc    12600

ccagacttga agcagtaacg gctgctgaaa atgttaggaa atacatgaat cagcctaaag    12660

tcattgtgta tgagactctg atgaaaggtc atgccatatt ttgtggaatc ataatcaacg    12720

gctatcgtga caggcacgga ggcagttggc caccgctgac cctccccctg catgctgcag    12780

acacaatccg gaatgctcaa gcttcaggtg aagggttaac acatgagcag tgcgttgata    12840

actggaaatc ttttgctgga gtgaaatttg gctgctttat gcctcttagc ctggatagtg    12900

atctgacaat gtacctaaag gacaaggcac ttgctgctct ccaaagggaa tgggattcag    12960

tttacccgaa agagttcctg cgttacgacc ctcccaaggg aaccgggtca cggaggcttg    13020

tagatgtttt ccttaatgat tcgagctttg acccatatga tgtgataatg tatgttgtaa    13080

gtggagctta cctccatgac cctgagttca acctgtctta cagcctgaaa gaaaaggaga    13140

tcaaggaaac aggtagactt tttgctaaaa tgacttacaa aatgagggca tgccaagtga    13200

ttgctgaaaa tctaatctca aacgggattg gcaaatattt taaggacaat gggatggcca    13260

aggatgagca cgatttgact aaggcactcc acactctagc tgtctcagga gtccccaaag    13320

atctcaaaga aagtcacagg ggggggccag tcttaaaaac ctactcccga agcccagtcc    13380

acacaagtac caggaacgtg agagcagcaa aagggtttat agggttccct caagtaattc    13440

ggcaggacca agacactgat catccggaga atatggaagc ttacgagaca gtcagtgcat    13500

ttatcacgac tgatctcaag aagtactgcc ttaattggag atatgagacc atcagcttgt    13560

ttgcacagag gctaaatgag atttacggat tgccctcatt tttccagtgg ctgcataaga    13620

ggcttgagac ctctgtcctg tatgtaagtg accctcattg cccccccgac cttgacgccc    13680

atatcccgtt atataaagtc cccaatgatc aaatcttcat taagtaccct atgggaggta    13740

tagaagggta ttgtcagaag ctgtggacca tcagcaccat tccctatcta tacctggctg    13800

cttatgagag cggagtaagg attgcttcgt tagtgcaagg ggacaatcag accatagccg    13860

taacaaaaag ggtacccagc acatggccct acaaccttaa gaaacgggaa gctgctagag    13920

taactagaga ttactttgta attcttaggc aaaggctaca tgatattggc catcacctca    13980

aggcaaatga gacaattgtt tcatcacatt tttttgtcta ttcaaaagga atatattatg    14040

atgggctact tgtgtcccaa tcactcaaga gcatcgcaag atgtgtattc tggtcagaga    14100

ctatagttga tgaaacaagg gcagcatgca gtaatattgc tacaacaatg gctaaaagca    14160

tcgagagagg ttatgaccgt taccttgcat attccctgaa cgtcctaaaa gtgatacagc    14220

aaattctgat ctctcttggc ttcacaatca attcaaccat gacccgggat gtagtcatac    14280

ccctcctcac aaacaacgac ctcttaataa ggatggcact gttgcccgct cctattgggg    14340

ggatgaatta tctgaatatg agcaggctgt ttgtcagaaa catcggtgat ccagtaacat    14400

catcaattgc tgatctcaag agaatgattc tcgcctcact aatgcctgaa gagaccctcc    14460

atcaagtaat gacacaacaa ccgggggact cttcattcct agactgggct agcgaccctt    14520

actcagcaaa tcttgtatgt gtccagagca tcactagact cctcaagaac ataactgcaa    14580

ggtttgtcct gatccatagt ccaaacccaa tgttaaaagg attattccat gatgacagta    14640

aagaagagga cgagggactg gcggcattcc tcatggacag gcatattata gtacctaggg    14700

cagctcatga aatcctggat catagtgtca caggggcaag agagtctatt gcaggcatgc    14760

tggataccac aaaaggcttg attcgagcca gcatgaggaa gggggggtta acctctcgag    14820

tgataaccag attgtccaat tatgactatg aacaattcag agcagggatg gtgctattga    14880

caggaagaaa gagaaatgtc ctcattgaca aagagtcatg ttcagtgcag ctggcgagag    14940

ctctaagaag ccatatgtgg gcgaggctag ctcgaggacg gcctatttac ggccttgagg    15000

tccctgatgt actagaatct atgcgaggcc accttattcg gcgtcatgag acatgtgtca    15060

tctgcgagtg tggatcagtc aactacggat ggttttttgt cccctcgggt tgccaactgg    15120

atgatattga caaggaaaca tcatccttga gagtcccata tattggttct accactgatg    15180

agagaacaga catgaagctt gccttcgtaa gagccccaag tcgatccttg cgatctgctg    15240

ttagaatagc aacagtgtac tcatgggctt acggtgatga tgatagctct tggaacgaag    15300

cctggttgtt ggctaggcaa agggccaatg tgagcctgga ggagctaagg gtgatcactc    15360

ccatctcaac ttcgactaat ttagcgcata ggttgaggga tcgtagcact caagtgaaat    15420

actcaggtac atcccttgtc cgagtggcga ggtataccac aatctccaac gacaatctct    15480

catttgtcat atcagataag aaggttgata ctaactttat ataccaacaa ggaatgcttc    15540

tagggttggg tgttttagaa acattgtttc gactcgagaa agataccgga tcatctaaca    15600

cggtattaca tcttcacgtc gaaacagatt gttgcgtgat cccgatgata gatcatccca    15660

ggatacccag ctcccgcaag ctagagctga gggcagagct atgtaccaac ccattgatat    15720

atgataatgc acctttaatt gacagagatg caacaaggct atacacccag agccatagga    15780

ggcaccttgt ggaatttgtt acatggtcca caccccaact atatcacatt ttagctaagt    15840

ccacagcact atctatgatt gacctggtaa caaaatttga gaaggaccat atgaatgaaa    15900

tttcagctct cataggggat gacgatatca atagtttcat aactgagttt ctgctcatag    15960

agccaagatt attcactatc tacttgggcc agtgtgcggc catcaattgg gcatttgatg    16020

tacattatca tagaccatca gggaaatatc agatgggtga gctgttgtca tcgttccttt    16080

ctagaatgag caaaggagtg tttaaggtgc ttgtcaatgc tctaagccac ccaaagatct    16140

acaagaaatt ctggcattgt ggtattatag agcctatcca tggtccttca cttgatgctc    16200

aaaacttgca cacaactgtg tgcaacatgg tttacacatg ctatatgacc tacctcgacc    16260

tgttgttgaa tgaagagtta gaagagttca catttctctt gtgtgaaagc gacgaggatg    16320

tagtaccgga cagattcgac aacatccagg caaaacactt atgtgttctg gcagatttgt    16380

actgtcaacc agggacctgc ccaccaattc gaggtctaag accggtagag aaatgtgcag    16440

ttctaaccga ccatatcaag gcagaggcta tgttatctcc agcaggatct tcgtggaaca    16500

taaatccaat tattgtagac cattactcat gctctctgac ttatctccgg cgaggatcga    16560

tcaaacagat aagattgaga gttgatccag gattcatttt cgacgccctc gctgaggtaa    16620

atgtcagtca gccaaagatc ggcagcaaca acatctcaaa tatgagcatc aaggctttca    16680

gacccccaca cgatgatgtt gcaaaattgc tcaaagatat caacacaagc aagcacaatc    16740

ttcccatttc agggggcaat ctcgccaatt atgaaatcca tgctttccgc agaatcgggt    16800

tgaactcatc tgcttgctac aaagctgttg agatatcaac attaattagg agatgccttg    16860

agccagggga ggacggcttg ttcttgggtg agggatcggg ttctatgttg atcacttata    16920

aagagatact taaactaaac aagtgcttct ataatagtgg ggtttccgcc aattctagat    16980

ctggtcaaag ggaattagca ccctatccct ccgaagttgg ccttgtcgaa cacagaatgg    17040

gagtaggtaa tattgtcaaa gtgctcttta acgggaggcc cgaagtcacg tgggtaggca    17100

gtgtagattg cttcaatttc atagttagta atatccctac ctctagtgtg gggtttatcc    17160

attcagatat agagaccttg cctgacaaag atactataga gaagctagag gaattggcag    17220

ccatcttatc gatggctctg ctcctgggca aaataggatc aatactggtg attaagctta    17280

tgcctttcag cggggatttt gttcagggat ttataagtta tgtagggtct cattatagag    17340

aagtgaacct tgtataccct agatacagca acttcatctc tactgaatct tatttggtta    17400

tgacagatct caaggctaac cggctaatga atcctgaaaa gattaagcag cagataattg    17460

aatcatctgt gaggacttca cctggactta taggtcacat cctatccatt aagcaactaa    17520

gctgcataca agcaattgtg ggagacgcag ttagtagagg tgatatcaat cctactctga    17580

aaaaacttac acctatagag caggtgctga tcaattgcgg gttggcaatt aacggaccta    17640

agctgtgcaa agaattgatc caccatgatg ttgcctcagg gcaagatgga ttgcttaatt    17700

ctatactcat cctctacagg gagttggcaa gattcaaaga caaccaaaga agtcaacaag    17760

ggatgttcca cgcttacccc gtattggtaa gtagcaggca acgagaactt atatctagga    17820

tcacccgcaa attctggggg cacattcttc tttactccgg gaacaaaaag ttgataaata    17880

agtttatcca gaatctcaag tccggctatc tgatactaga cttacaccag aatatcttcg    17940

ttaagaatct atccaagtca gagaaacaga ttattatgac ggggggtttg aaacgtgagt    18000

gggtttttaa ggtaacagtc aaggagacca aagaatggta taagttagtc ggatacagtg    18060

ccctgattaa ggactaattg gttgaactcc ggaaccctaa tcctgcccta ggtggttagg    18120

cattatttgc aatatattaa agaaaacttt gaaaatacga agtttctatt cccagctttg    18180

tctggtggcc ggcatggtcc cagcctcctc gctggcgccg gctgggcaac attccgaggg    18240

gaccgtcccc tcggtaatgg cgaatgggac gcggccgatc cggctgctaa caaagcccga    18300

aaggaagctg agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc    18360

tctaaacggg tcttgagggg ttttttgctg aaaggaggaa ctatatccgg atgcggccgc    18420

gggccctatg gtacccagct tttgttccct ttagtgaggg ttaattccga gcttggcgta    18480

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat    18540

aggagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgaggt aactcacatt    18600

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta    18660

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc    18720

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa    18780

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa    18840

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct    18900

cggcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac    18960

aggactataa agataccagg cgttcccccc tggaagctcc ctcgtgcgct ctcctgttcc    19020

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc    19080

tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg    19140

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga    19200

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag    19260

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta    19320

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag    19380

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg    19440

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac    19500

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc    19560

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag    19620

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc    19680

agcgatctgt ctatttcgtt catccatagt tgcctgactg cccgtcgtgt agataactac    19740

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc    19800

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg    19860

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag    19920

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc    19980

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac    20040

atgatccccc atgttgtgaa aaaaagcggt tagctccttc ggtcctccga tcgttgtcag    20100

aagtaagttg gccgcagtgt tatcactcat gcttatggca gcactgcata attctcttac    20160

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg    20220

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc    20280

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact    20340

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg    20400

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa    20460

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt    20520

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg    20580

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga    20640

aattgtaaac gttaatattt tgttaaaatt cgcgttaaat ttttgttaaa tcagctcatt    20700

ttttaaccaa taggccgaaa tcggcaaaat cccttataaa tcaaaagaat agaccgagat    20760

agggttgagt gttgttccag tttggaacaa gagtccacta ttaaagaacg tggactccaa    20820

cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca ctacgtgaac catcacccta    20880

atcaagtttt ttggggtcga ggtgccgtaa agcactaaat cggaacccta aagggagccc    20940

ccgatttaga gcttgacggg gaaagccggc gaacgtggcg agaaaggaag ggaagaaagc    21000

gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc acgctgcgcg taaccaccac    21060

acccgccgcg cttaatgcgc cgctacaggg cgcgtcccat tcgccattca ggctgcgcaa    21120

ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccagccac cgcggtgatc    21180

cttataaagc tagatg                                                    21196


<210>  59
<211>  18994
<212>  DNA
<213>  Measles virus Schwarz strain pTM - pTM MV Schw

<400>  59
tcatgaacgc ggccgctaat acgactcact atagggccaa ctttgtttgg tctgatgagt       60

ccgtgaggac gaaacccgga gtcccgggtc accaaacaaa gttgggtaag gatagttcaa      120

tcaatgatca tcttctagtg cacttaggat tcaagatcct attatcaggg acaagagcag      180

gattagggat atccgagatg gccacacttt taaggagctt agcattgttc aaaagaaaca      240

aggacaaacc acccattaca tcaggatccg gtggagccat cagaggaatc aaacacatta      300

ttatagtacc aatccctgga gattcctcaa ttaccactcg atccagactt ctggaccggt      360

tggtgaggtt aattggaaac ccggatgtga gcgggcccaa actaacaggg gcactaatag      420

gtatattatc cttatttgtg gagtctccag gtcaattgat tcagaggatc accgatgacc      480

ctgacgttag cataaggctg ttagaggttg tccagagtga ccagtcacaa tctggcctta      540

ccttcgcatc aagaggtacc aacatggagg atgaggcgga ccaatacttt tcacatgatg      600

atccaattag tagtgatcaa tccaggttcg gatggttcgg gaacaaggaa atctcagata      660

ttgaagtgca agaccctgag ggattcaaca tgattctggg taccatccta gcccaaattt      720

gggtcttgct cgcaaaggcg gttacggccc cagacacggc agctgattcg gagctaagaa      780

ggtggataaa gtacacccaa caaagaaggg tagttggtga atttagattg gagagaaaat      840

ggttggatgt ggtgaggaac aggattgccg aggacctctc cttacgccga ttcatggtcg      900

ctctaatcct ggatatcaag agaacacccg gaaacaaacc caggattgct gaaatgatat      960

gtgacattga tacatatatc gtagaggcag gattagccag ttttatcctg actattaagt     1020

ttgggataga aactatgtat cctgctcttg gactgcatga atttgctggt gagttatcca     1080

cacttgagtc cttgatgaac ctttaccagc aaatggggga aactgcaccc tacatggtaa     1140

tcctggagaa ctcaattcag aacaagttca gtgcaggatc ataccctctg ctctggagct     1200

atgccatggg agtaggagtg gaacttgaaa actccatggg aggtttgaac tttggccgat     1260

cttactttga tccagcatat tttagattag ggcaagagat ggtaaggagg tcagctggaa     1320

aggtcagttc cacattggca tctgaactcg gtatcactgc cgaggatgca aggcttgttt     1380

cagagattgc aatgcatact actgaggaca agatcagtag agcggttgga cccagacaag     1440

cccaagtatc atttctacac ggtgatcaaa gtgagaatga gctaccgaga ttggggggca     1500

aggaagatag gagggtcaaa cagagtcgag gagaagccag ggagagctac agagaaaccg     1560

ggcccagcag agcaagtgat gcgagagctg cccatcttcc aaccggcaca cccctagaca     1620

ttgacactgc aacggagtcc agccaagatc cgcaggacag tcgaaggtca gctgacgccc     1680

tgcttaggct gcaagccatg gcaggaatct cggaagaaca aggctcagac acggacaccc     1740

ctatagtgta caatgacaga aatcttctag actaggtgcg agaggccgag ggccagaaca     1800

acatccgcct accatccatc attgttataa aaaacttagg aaccaggtcc acacagccgc     1860

cagcccatca accatccact cccacgattg gagccaatgg cagaagagca ggcacgccat     1920

gtcaaaaacg gactggaatg catccgggct ctcaaggccg agcccatcgg ctcactggcc     1980

atcgaggaag ctatggcagc atggtcagaa atatcagaca acccaggaca ggagcgagcc     2040

acctgcaggg aagagaaggc aggcagttcg ggtctcagca aaccatgcct ctcagcaatt     2100

ggatcaactg aaggcggtgc acctcgcatc cgcggtcagg gacctggaga gagcgatgac     2160

gacgctgaaa ctttgggaat ccccccaaga aatctccagg catcaagcac tgggttacag     2220

tgttattacg tttatgatca cagcggtgaa gcggttaagg gaatccaaga tgctgactct     2280

atcatggttc aatcaggcct tgatggtgat agcaccctct caggaggaga caatgaatct     2340

gaaaacagcg atgtggatat tggcgaacct gataccgagg gatatgctat cactgaccgg     2400

ggatctgctc ccatctctat ggggttcagg gcttctgatg ttgaaactgc agaaggaggg     2460

gagatccacg agctcctgag actccaatcc agaggcaaca actttccgaa gcttgggaaa     2520

actctcaatg ttcctccgcc cccggacccc ggtagggcca gcacttccgg gacacccatt     2580

aaaaagggca cagacgcgag attagcctca tttggaacgg agatcgcgtc tttattgaca     2640

ggtggtgcaa cccaatgtgc tcgaaagtca ccctcggaac catcagggcc aggtgcacct     2700

gcggggaatg tccccgagtg tgtgagcaat gccgcactga tacaggagtg gacacccgaa     2760

tctggtacca caatctcccc gagatcccag aataatgaag aagggggaga ctattatgat     2820

gatgagctgt tctctgatgt ccaagatatt aaaacagcct tggccaaaat acacgaggat     2880

aatcagaaga taatctccaa gctagaatca ctgctgttat tgaagggaga agttgagtca     2940

attaagaagc agatcaacag gcaaaatatc agcatatcca ccctggaagg acacctctca     3000

agcatcatga tcgccattcc tggacttggg aaggatccca acgaccccac tgcagatgtc     3060

gaaatcaatc ccgacttgaa acccatcata ggcagagatt caggccgagc actggccgaa     3120

gttctcaaga aacccgttgc cagccgacaa ctccaaggaa tgacaaatgg acggaccagt     3180

tccagaggac agctgctgaa ggaatttcag ctaaagccga tcgggaaaaa gatgagctca     3240

gccgtcgggt ttgttcctga caccggccct gcatcacgca gtgtaatccg ctccattata     3300

aaatccagcc ggctagagga ggatcggaag cgttacctga tgactctcct tgatgatatc     3360

aaaggagcca atgatcttgc caagttccac cagatgctga tgaagataat aatgaagtag     3420

ctacagctca acttacctgc caaccccatg ccagtcgacc caactagtac aacctaaatc     3480

cattataaaa aacttaggag caaagtgatt gcctcccaag gtccacaatg acagagacct     3540

acgacttcga caagtcggca tgggacatca aagggtcgat cgctccgata caacccacca     3600

cctacagtga tggcaggctg gtgccccagg tcagagtcat agatcctggt ctaggcgaca     3660

ggaaggatga atgctttatg tacatgtttc tgctgggggt tgttgaggac agcgattccc     3720

tagggcctcc aatcgggcga gcatttgggt tcctgccctt aggtgttggc agatccacag     3780

caaagcccga aaaactcctc aaagaggcca ctgagcttga catagttgtt agacgtacag     3840

cagggctcaa tgaaaaactg gtgttctaca acaacacccc actaactctc ctcacacctt     3900

ggagaaaggt cctaacaaca gggagtgtct tcaacgcaaa ccaagtgtgc aatgcggtta     3960

atctgatacc gctcgatacc ccgcagaggt tccgtgttgt ttatatgagc atcacccgtc     4020

tttcggataa cgggtattac accgttccta gaagaatgct ggaattcaga tcggtcaatg     4080

cagtggcctt caacctgctg gtgaccctta ggattgacaa ggcgataggc cctgggaaga     4140

tcatcgacaa tacagagcaa cttcctgagg caacatttat ggtccacatc gggaacttca     4200

ggagaaagaa gagtgaagtc tactctgccg attattgcaa aatgaaaatc gaaaagatgg     4260

gcctggtttt tgcacttggt gggatagggg gcaccagtct tcacattaga agcacaggca     4320

aaatgagcaa gactctccat gcacaactcg ggttcaagaa gaccttatgt tacccgctga     4380

tggatatcaa tgaagacctt aatcgattac tctggaggag cagatgcaag atagtaagaa     4440

tccaggcagt tttgcagcca tcagttcctc aagaattccg catttacgac gacgtgatca     4500

taaatgatga ccaaggacta ttcaaagttc tgtagaccgt agtgcccagc aatgcccgaa     4560

aacgaccccc ctcacaatga cagccagaag gcccggacaa aaaagccccc tccgaaagac     4620

tccacggacc aagcgagagg ccagccagca gccgacggca agcgcgaaca ccaggcggcc     4680

ccagcacaga acagccctga cacaaggcca ccaccagcca ccccaatctg catcctcctc     4740

gtgggacccc cgaggaccaa cccccaaggc tgcccccgat ccaaaccacc aaccgcatcc     4800

ccaccacccc cgggaaagaa acccccagca attggaaggc ccctccccct cttcctcaac     4860

acaagaactc cacaaccgaa ccgcacaagc gaccgaggtg acccaaccgc aggcatccga     4920

ctccctagac agatcctctc tccccggcaa actaaacaaa acttagggcc aaggaacata     4980

cacacccaac agaacccaga ccccggccca cggcgccgcg cccccaaccc ccgacaacca     5040

gagggagccc ccaaccaatc ccgccggctc ccccggtgcc cacaggcagg gacaccaacc     5100

cccgaacaga cccagcaccc aaccatcgac aatccaagac gggggggccc ccccaaaaaa     5160

aggcccccag gggccgacag ccagcaccgc gaggaagccc acccacccca cacacgacca     5220

cggcaaccaa accagaaccc agaccaccct gggccaccag ctcccagact cggccatcac     5280

cccgcagaaa ggaaaggcca caacccgcgc accccagccc cgatccggcg gggagccacc     5340

caacccgaac cagcacccaa gagcgatccc cgaaggaccc ccgaaccgca aaggacatca     5400

gtatcccaca gcctctccaa gtcccccggt ctcctcctct tctcgaaggg accaaaagat     5460

caatccacca cacccgacga cactcaactc cccaccccta aaggagacac cgggaatccc     5520

agaatcaaga ctcatccaat gtccatcatg ggtctcaagg tgaacgtctc tgccatattc     5580

atggcagtac tgttaactct ccaaacaccc accggtcaaa tccattgggg caatctctct     5640

aagatagggg tggtaggaat aggaagtgca agctacaaag ttatgactcg ttccagccat     5700

caatcattag tcataaaatt aatgcccaat ataactctcc tcaataactg cacgagggta     5760

gagattgcag aatacaggag actactgaga acagttttgg aaccaattag agatgcactt     5820

aatgcaatga cccagaatat aagaccggtt cagagtgtag cttcaagtag gagacacaag     5880

agatttgcgg gagtagtcct ggcaggtgcg gccctaggcg ttgccacagc tgctcagata     5940

acagccggca ttgcacttca ccagtccatg ctgaactctc aagccatcga caatctgaga     6000

gcgagcctgg aaactactaa tcaggcaatt gagacaatca gacaagcagg gcaggagatg     6060

atattggctg ttcagggtgt ccaagactac atcaataatg agctgatacc gtctatgaac     6120

caactatctt gtgatttaat cggccagaag ctcgggctca aattgctcag atactataca     6180

gaaatcctgt cattatttgg ccccagttta cgggacccca tatctgcgga gatatctatc     6240

caggctttga gctatgcgct tggaggagac atcaataagg tgttagaaaa gctcggatac     6300

agtggaggtg atttactggg catcttagag agcggaggaa taaaggcccg gataactcac     6360

gtcgacacag agtcctactt cattgtcctc agtatagcct atccgacgct gtccgagatt     6420

aagggggtga ttgtccaccg gctagagggg gtctcgtaca acataggctc tcaagagtgg     6480

tataccactg tgcccaagta tgttgcaacc caagggtacc ttatctcgaa ttttgatgag     6540

tcatcgtgta ctttcatgcc agaggggact gtgtgcagcc aaaatgcctt gtacccgatg     6600

agtcctctgc tccaagaatg cctccggggg tacaccaagt cctgtgctcg tacactcgta     6660

tccgggtctt ttgggaaccg gttcatttta tcacaaggga acctaatagc caattgtgca     6720

tcaatccttt gcaagtgtta cacaacagga acgatcatta atcaagaccc tgacaagatc     6780

ctaacataca ttgctgccga tcactgcccg gtagtcgagg tgaacggcgt gaccatccaa     6840

gtcgggagca ggaggtatcc agacgctgtg tacttgcaca gaattgacct cggtcctccc     6900

atatcattgg agaggttgga cgtagggaca aatctgggga atgcaattgc taagttggag     6960

gatgccaagg aattgttgga gtcatcggac cagatattga ggagtatgaa aggtttatcg     7020

agcactagca tagtctacat cctgattgca gtgtgtcttg gagggttgat agggatcccc     7080

gctttaatat gttgctgcag ggggcgttgt aacaaaaagg gagaacaagt tggtatgtca     7140

agaccaggcc taaagcctga tcttacggga acatcaaaat cctatgtaag gtcgctctga     7200

tcctctacaa ctcttgaaac acaaatgtcc cacaagtctc ctcttcgtca tcaagcaacc     7260

accgcaccca gcatcaagcc cacctgaaat tatctccggc ttccctctgg ccgaacaata     7320

tcggtagtta atcaaaactt agggtgcaag atcatccaca atgtcaccac aacgagaccg     7380

gataaatgcc ttctacaaag ataaccccca tcccaaggga agtaggatag tcattaacag     7440

agaacatctt atgattgata gaccttatgt tttgctggct gttctgtttg tcatgtttct     7500

gagcttgatc gggttgctag ccattgcagg cattagactt catcgggcag ccatctacac     7560

cgcagagatc cataaaagcc tcagcaccaa tctagatgta actaactcaa tcgagcatca     7620

ggtcaaggac gtgctgacac cactcttcaa aatcatcggt gatgaagtgg gcctgaggac     7680

acctcagaga ttcactgacc tagtgaaatt aatctctgac aagattaaat tccttaatcc     7740

ggatagggag tacgacttca gagatctcac ttggtgtatc aacccgccag agagaatcaa     7800

attggattat gatcaatact gtgcagatgt ggctgctgaa gagctcatga atgcattggt     7860

gaactcaact ctactggaga ccagaacaac caatcagttc ctagctgtct caaagggaaa     7920

ctgctcaggg cccactacaa tcagaggtca attctcaaac atgtcgctgt ccctgttaga     7980

cttgtattta ggtcgaggtt acaatgtgtc atctatagtc actatgacat cccagggaat     8040

gtatggggga acttacctag tggaaaagcc taatctgagc agcaaaaggt cagagttgtc     8100

acaactgagc atgtaccgag tgtttgaagt aggtgttatc agaaatccgg gtttgggggc     8160

tccggtgttc catatgacaa actatcttga gcaaccagtc agtaatgatc tcagcaactg     8220

tatggtggct ttgggggagc tcaaactcgc agccctttgt cacggggaag attctatcac     8280

aattccctat cagggatcag ggaaaggtgt cagcttccag ctcgtcaagc taggtgtctg     8340

gaaatcccca accgacatgc aatcctgggt ccccttatca acggatgatc cagtgataga     8400

caggctttac ctctcatctc acagaggtgt tatcgctgac aatcaagcaa aatgggctgt     8460

cccgacaaca cgaacagatg acaagttgcg aatggagaca tgcttccaac aggcgtgtaa     8520

gggtaaaatc caagcactct gcgagaatcc cgagtgggca ccattgaagg ataacaggat     8580

tccttcatac ggggtcttgt ctgttgatct gagtctgaca gttgagctta aaatcaaaat     8640

tgcttcggga ttcgggccat tgatcacaca cggttcaggg atggacctat acaaatccaa     8700

ccacaacaat gtgtattggc tgactatccc gccaatgaag aacctagcct taggtgtaat     8760

caacacattg gagtggatac cgagattcaa ggttagtccc tacctcttca ctgtcccaat     8820

taaggaagca ggcgaagact gccatgcccc aacataccta cctgcggagg tggatggtga     8880

tgtcaaactc agttccaatc tggtgattct acctggtcaa gatctccaat atgttttggc     8940

aacctacgat acttccaggg ttgaacatgc tgtggtttat tacgtttaca gcccaagccg     9000

ctcattttct tacttttatc cttttaggtt gcctataaag ggggtcccca tcgaattaca     9060

agtggaatgc ttcacatggg accaaaaact ctggtgccgt cacttctgtg tgcttgcgga     9120

ctcagaatct ggtggacata tcactcactc tgggatggtg ggcatgggag tcagctgcac     9180

agtcacccgg gaagatggaa ccaatcgcag atagggctgc tagtgaacca atcacatgat     9240

gtcacccaga catcaggcat acccactagt gtgaaataga catcagaatt aagaaaaacg     9300

tagggtccaa gtggttcccc gttatggact cgctatctgt caaccagatc ttataccctg     9360

aagttcacct agatagcccg atagttacca ataagatagt agccatcctg gagtatgctc     9420

gagtccctca cgcttacagc ctggaggacc ctacactgtg tcagaacatc aagcaccgcc     9480

taaaaaacgg attttccaac caaatgatta taaacaatgt ggaagttggg aatgtcatca     9540

agtccaagct taggagttat ccggcccact ctcatattcc atatccaaat tgtaatcagg     9600

atttatttaa catagaagac aaagagtcaa cgaggaagat ccgtgaactc ctcaaaaagg     9660

ggaattcgct gtactccaaa gtcagtgata aggttttcca atgcttaagg gacactaact     9720

cacggcttgg cctaggctcc gaattgaggg aggacatcaa ggagaaagtt attaacttgg     9780

gagtttacat gcacagctcc cagtggtttg agccctttct gttttggttt acagtcaaga     9840

ctgagatgag gtcagtgatt aaatcacaaa cccatacttg ccataggagg agacacacac     9900

ctgtattctt cactggtagt tcagttgagt tgctaatctc tcgtgacctt gttgctataa     9960

tcagtaaaga gtctcaacat gtatattacc tgacatttga actggttttg atgtattgtg    10020

atgtcataga ggggaggtta atgacagaga ccgctatgac tattgatgct aggtatacag    10080

agcttctagg aagagtcaga tacatgtgga aactgataga tggtttcttc cctgcactcg    10140

ggaatccaac ttatcaaatt gtagccatgc tggagcctct ttcacttgct tacctgcagc    10200

tgagggatat aacagtagaa ctcagaggtg ctttccttaa ccactgcttt actgaaatac    10260

atgatgttct tgaccaaaac gggttttctg atgaaggtac ttatcatgag ttaactgaag    10320

ctctagatta cattttcata actgatgaca tacatctgac aggggagatt ttctcatttt    10380

tcagaagttt cggccacccc agacttgaag cagtaacggc tgctgaaaat gttaggaaat    10440

acatgaatca gcctaaagtc attgtgtatg agactctgat gaaaggtcat gccatatttt    10500

gtggaatcat aatcaacggc tatcgtgaca ggcacggagg cagttggcca ccgctgaccc    10560

tccccctgca tgctgcagac acaatccgga atgctcaagc ttcaggtgaa gggttaacac    10620

atgagcagtg cgttgataac tggaaatctt ttgctggagt gaaatttggc tgctttatgc    10680

ctcttagcct ggatagtgat ctgacaatgt acctaaagga caaggcactt gctgctctcc    10740

aaagggaatg ggattcagtt tacccgaaag agttcctgcg ttacgaccct cccaagggaa    10800

ccgggtcacg gaggcttgta gatgttttcc ttaatgattc gagctttgac ccatatgatg    10860

tgataatgta tgttgtaagt ggagcttacc tccatgaccc tgagttcaac ctgtcttaca    10920

gcctgaaaga aaaggagatc aaggaaacag gtagactttt tgctaaaatg acttacaaaa    10980

tgagggcatg ccaagtgatt gctgaaaatc taatctcaaa cgggattggc aaatatttta    11040

aggacaatgg gatggccaag gatgagcacg atttgactaa ggcactccac actctagctg    11100

tctcaggagt ccccaaagat ctcaaagaaa gtcacagggg ggggccagtc ttaaaaacct    11160

actcccgaag cccagtccac acaagtacca ggaacgtgag agcagcaaaa gggtttatag    11220

ggttccctca agtaattcgg caggaccaag acactgatca tccggagaat atggaagctt    11280

acgagacagt cagtgcattt atcacgactg atctcaagaa gtactgcctt aattggagat    11340

atgagaccat cagcttgttt gcacagaggc taaatgagat ttacggattg ccctcatttt    11400

tccagtggct gcataagagg cttgagacct ctgtcctgta tgtaagtgac cctcattgcc    11460

cccccgacct tgacgcccat atcccgttat ataaagtccc caatgatcaa atcttcatta    11520

agtaccctat gggaggtata gaagggtatt gtcagaagct gtggaccatc agcaccattc    11580

cctatctata cctggctgct tatgagagcg gagtaaggat tgcttcgtta gtgcaagggg    11640

acaatcagac catagccgta acaaaaaggg tacccagcac atggccctac aaccttaaga    11700

aacgggaagc tgctagagta actagagatt actttgtaat tcttaggcaa aggctacatg    11760

atattggcca tcacctcaag gcaaatgaga caattgtttc atcacatttt tttgtctatt    11820

caaaaggaat atattatgat gggctacttg tgtcccaatc actcaagagc atcgcaagat    11880

gtgtattctg gtcagagact atagttgatg aaacaagggc agcatgcagt aatattgcta    11940

caacaatggc taaaagcatc gagagaggtt atgaccgtta ccttgcatat tccctgaacg    12000

tcctaaaagt gatacagcaa attctgatct ctcttggctt cacaatcaat tcaaccatga    12060

cccgggatgt agtcataccc ctcctcacaa acaacgacct cttaataagg atggcactgt    12120

tgcccgctcc tattgggggg atgaattatc tgaatatgag caggctgttt gtcagaaaca    12180

tcggtgatcc agtaacatca tcaattgctg atctcaagag aatgattctc gcctcactaa    12240

tgcctgaaga gaccctccat caagtaatga cacaacaacc gggggactct tcattcctag    12300

actgggctag cgacccttac tcagcaaatc ttgtatgtgt ccagagcatc actagactcc    12360

tcaagaacat aactgcaagg tttgtcctga tccatagtcc aaacccaatg ttaaaaggat    12420

tattccatga tgacagtaaa gaagaggacg agggactggc ggcattcctc atggacaggc    12480

atattatagt acctagggca gctcatgaaa tcctggatca tagtgtcaca ggggcaagag    12540

agtctattgc aggcatgctg gataccacaa aaggcttgat tcgagccagc atgaggaagg    12600

gggggttaac ctctcgagtg ataaccagat tgtccaatta tgactatgaa caattcagag    12660

cagggatggt gctattgaca ggaagaaaga gaaatgtcct cattgacaaa gagtcatgtt    12720

cagtgcagct ggcgagagct ctaagaagcc atatgtgggc gaggctagct cgaggacggc    12780

ctatttacgg ccttgaggtc cctgatgtac tagaatctat gcgaggccac cttattcggc    12840

gtcatgagac atgtgtcatc tgcgagtgtg gatcagtcaa ctacggatgg ttttttgtcc    12900

cctcgggttg ccaactggat gatattgaca aggaaacatc atccttgaga gtcccatata    12960

ttggttctac cactgatgag agaacagaca tgaagcttgc cttcgtaaga gccccaagtc    13020

gatccttgcg atctgctgtt agaatagcaa cagtgtactc atgggcttac ggtgatgatg    13080

atagctcttg gaacgaagcc tggttgttgg ctaggcaaag ggccaatgtg agcctggagg    13140

agctaagggt gatcactccc atctcaactt cgactaattt agcgcatagg ttgagggatc    13200

gtagcactca agtgaaatac tcaggtacat cccttgtccg agtggcgagg tataccacaa    13260

tctccaacga caatctctca tttgtcatat cagataagaa ggttgatact aactttatat    13320

accaacaagg aatgcttcta gggttgggtg ttttagaaac attgtttcga ctcgagaaag    13380

ataccggatc atctaacacg gtattacatc ttcacgtcga aacagattgt tgcgtgatcc    13440

cgatgataga tcatcccagg atacccagct cccgcaagct agagctgagg gcagagctat    13500

gtaccaaccc attgatatat gataatgcac ctttaattga cagagatgca acaaggctat    13560

acacccagag ccataggagg caccttgtgg aatttgttac atggtccaca ccccaactat    13620

atcacatttt agctaagtcc acagcactat ctatgattga cctggtaaca aaatttgaga    13680

aggaccatat gaatgaaatt tcagctctca taggggatga cgatatcaat agtttcataa    13740

ctgagtttct gctcatagag ccaagattat tcactatcta cttgggccag tgtgcggcca    13800

tcaattgggc atttgatgta cattatcata gaccatcagg gaaatatcag atgggtgagc    13860

tgttgtcatc gttcctttct agaatgagca aaggagtgtt taaggtgctt gtcaatgctc    13920

taagccaccc aaagatctac aagaaattct ggcattgtgg tattatagag cctatccatg    13980

gtccttcact tgatgctcaa aacttgcaca caactgtgtg caacatggtt tacacatgct    14040

atatgaccta cctcgacctg ttgttgaatg aagagttaga agagttcaca tttctcttgt    14100

gtgaaagcga cgaggatgta gtaccggaca gattcgacaa catccaggca aaacacttat    14160

gtgttctggc agatttgtac tgtcaaccag ggacctgccc accaattcga ggtctaagac    14220

cggtagagaa atgtgcagtt ctaaccgacc atatcaaggc agaggctatg ttatctccag    14280

caggatcttc gtggaacata aatccaatta ttgtagacca ttactcatgc tctctgactt    14340

atctccggcg aggatcgatc aaacagataa gattgagagt tgatccagga ttcattttcg    14400

acgccctcgc tgaggtaaat gtcagtcagc caaagatcgg cagcaacaac atctcaaata    14460

tgagcatcaa ggctttcaga cccccacacg atgatgttgc aaaattgctc aaagatatca    14520

acacaagcaa gcacaatctt cccatttcag ggggcaatct cgccaattat gaaatccatg    14580

ctttccgcag aatcgggttg aactcatctg cttgctacaa agctgttgag atatcaacat    14640

taattaggag atgccttgag ccaggggagg acggcttgtt cttgggtgag ggatcgggtt    14700

ctatgttgat cacttataaa gagatactta aactaaacaa gtgcttctat aatagtgggg    14760

tttccgccaa ttctagatct ggtcaaaggg aattagcacc ctatccctcc gaagttggcc    14820

ttgtcgaaca cagaatggga gtaggtaata ttgtcaaagt gctctttaac gggaggcccg    14880

aagtcacgtg ggtaggcagt gtagattgct tcaatttcat agttagtaat atccctacct    14940

ctagtgtggg gtttatccat tcagatatag agaccttgcc tgacaaagat actatagaga    15000

agctagagga attggcagcc atcttatcga tggctctgct cctgggcaaa ataggatcaa    15060

tactggtgat taagcttatg cctttcagcg gggattttgt tcagggattt ataagttatg    15120

tagggtctca ttatagagaa gtgaaccttg tataccctag atacagcaac ttcatctcta    15180

ctgaatctta tttggttatg acagatctca aggctaaccg gctaatgaat cctgaaaaga    15240

ttaagcagca gataattgaa tcatctgtga ggacttcacc tggacttata ggtcacatcc    15300

tatccattaa gcaactaagc tgcatacaag caattgtggg agacgcagtt agtagaggtg    15360

atatcaatcc tactctgaaa aaacttacac ctatagagca ggtgctgatc aattgcgggt    15420

tggcaattaa cggacctaag ctgtgcaaag aattgatcca ccatgatgtt gcctcagggc    15480

aagatggatt gcttaattct atactcatcc tctacaggga gttggcaaga ttcaaagaca    15540

accaaagaag tcaacaaggg atgttccacg cttaccccgt attggtaagt agcaggcaac    15600

gagaacttat atctaggatc acccgcaaat tctgggggca cattcttctt tactccggga    15660

acaaaaagtt gataaataag tttatccaga atctcaagtc cggctatctg atactagact    15720

tacaccagaa tatcttcgtt aagaatctat ccaagtcaga gaaacagatt attatgacgg    15780

ggggtttgaa acgtgagtgg gtttttaagg taacagtcaa ggagaccaaa gaatggtata    15840

agttagtcgg atacagtgcc ctgattaagg actaattggt tgaactccgg aaccctaatc    15900

ctgccctagg tggttaggca ttatttgcaa tatattaaag aaaactttga aaatacgaag    15960

tttctattcc cagctttgtc tggtggccgg catggtccca gcctcctcgc tggcgccggc    16020

tgggcaacat tccgagggga ccgtcccctc ggtaatggcg aatgggacgc ggccgatccg    16080

gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta    16140

gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact    16200

atatccggat gcggccgcgg gccctatggt acccagcttt tgttcccttt agtgagggtt    16260

aattccgagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct    16320

cacaattcca cacaacatag gagccggaag cataaagtgt aaagcctggg gtgcctaatg    16380

agtgaggtaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct    16440

gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg    16500

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc    16560

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg    16620

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct    16680

ggcgtttttc cataggctcg gcccccctga cgagcatcac aaaaatcgac gctcaagtca    16740

gaggtggcga aacccgacag gactataaag ataccaggcg ttcccccctg gaagctccct    16800

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc    16860

gggaagcgtg gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt    16920

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc    16980

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc    17040

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg    17100

gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc    17160

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag    17220

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga    17280

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat    17340

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag    17400

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat    17460

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactgcc    17520

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat    17580

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag    17640

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg    17700

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc    17760

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca    17820

acgatcaagg cgagttacat gatcccccat gttgtgaaaa aaagcggtta gctccttcgg    17880

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgc ttatggcagc    17940

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta    18000

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc    18060

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg    18120

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc    18180

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc    18240

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat    18300

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag    18360

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc    18420

ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg ttaaaattcg cgttaaattt    18480

ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc    18540

aaaagaatag accgagatag ggttgagtgt tgttccagtt tggaacaaga gtccactatt    18600

aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg atggcccact    18660

acgtgaacca tcaccctaat caagtttttt ggggtcgagg tgccgtaaag cactaaatcg    18720

gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga acgtggcgag    18780

aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg tagcggtcac    18840

gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg cgtcccattc    18900

gccattcagg ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg    18960

ccagccaccg cggtgatcct tataaagcta gatg                                18994


<210>  60
<211>  19107
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pTM 2ATU MV Schw - Measles virus scaffold with ATU

<400>  60
tccaaccgcg cgcgcggccg ctaatacgac tcactatagg gccaactttg tttggtctga       60

tgagtccgtg aggacgaaac ccggagtccc gggtcaccaa acaaagttgg gtaaggatag      120

ttcaatcaat gatcatcttc tagtgcactt aggattcaag atcctattat cagggacaag      180

agcaggatta gggatatccg agatggccac acttttaagg agcttagcat tgttcaaaag      240

aaacaaggac aaaccaccca ttacatcagg atccggtgga gccatcagag gaatcaaaca      300

cattattata gtaccaatcc ctggagattc ctcaattacc actcgatcca gacttctgga      360

ccggttggtg aggttaattg gaaacccgga tgtgagcggg cccaaactaa caggggcact      420

aataggtata ttatccttat ttgtggagtc tccaggtcaa ttgattcaga ggatcaccga      480

tgaccctgac gttagcataa ggctgttaga ggttgtccag agtgaccagt cacaatctgg      540

ccttaccttc gcatcaagag gtaccaacat ggaggatgag gcggaccaat acttttcaca      600

tgatgatcca attagtagtg atcaatccag gttcggatgg ttcgggaaca aggaaatctc      660

agatattgaa gtgcaagacc ctgagggatt caacatgatt ctgggtacca tcctagccca      720

aatttgggtc ttgctcgcaa aggcggttac ggccccagac acggcagctg attcggagct      780

aagaaggtgg ataaagtaca cccaacaaag aagggtagtt ggtgaattta gattggagag      840

aaaatggttg gatgtggtga ggaacaggat tgccgaggac ctctccttac gccgattcat      900

ggtcgctcta atcctggata tcaagagaac acccggaaac aaacccagga ttgctgaaat      960

gatatgtgac attgatacat atatcgtaga ggcaggatta gccagtttta tcctgactat     1020

taagtttggg atagaaacta tgtatcctgc tcttggactg catgaatttg ctggtgagtt     1080

atccacactt gagtccttga tgaaccttta ccagcaaatg ggggaaactg caccctacat     1140

ggtaatcctg gagaactcaa ttcagaacaa gttcagtgca ggatcatacc ctctgctctg     1200

gagctatgcc atgggagtag gagtggaact tgaaaactcc atgggaggtt tgaactttgg     1260

ccgatcttac tttgatccag catattttag attagggcaa gagatggtaa ggaggtcagc     1320

tggaaaggtc agttccacat tggcatctga actcggtatc actgccgagg atgcaaggct     1380

tgtttcagag attgcaatgc atactactga ggacaagatc agtagagcgg ttggacccag     1440

acaagcccaa gtatcatttc tacacggtga tcaaagtgag aatgagctac cgagattggg     1500

gggcaaggaa gataggaggg tcaaacagag tcgaggagaa gccagggaga gctacagaga     1560

aaccgggccc agcagagcaa gtgatgcgag agctgcccat cttccaaccg gcacacccct     1620

agacattgac actgcaacgg agtccagcca agatccgcag gacagtcgaa ggtcagctga     1680

cgccctgctt aggctgcaag ccatggcagg aatctcggaa gaacaaggct cagacacgga     1740

cacccctata gtgtacaatg acagaaatct tctagactag gtgcgagagg ccgagggcca     1800

gaacaacatc cgcctaccat ccatcattgt tataaaaaac ttaggaacca ggtccacaca     1860

gccgccagcc catcaaccat ccactcccac gattggagcc aatggcagaa gagcaggcac     1920

gccatgtcaa aaacggactg gaatgcatcc gggctctcaa ggccgagccc atcggctcac     1980

tggccatcga ggaagctatg gcagcatggt cagaaatatc agacaaccca ggacaggagc     2040

gagccacctg cagggaagag aaggcaggca gttcgggtct cagcaaacca tgcctctcag     2100

caattggatc aactgaaggc ggtgcacctc gcatccgcgg tcagggacct ggagagagcg     2160

atgacgacgc tgaaactttg ggaatccccc caagaaatct ccaggcatca agcactgggt     2220

tacagtgtta ttacgtttat gatcacagcg gtgaagcggt taagggaatc caagatgctg     2280

actctatcat ggttcaatca ggccttgatg gtgatagcac cctctcagga ggagacaatg     2340

aatctgaaaa cagcgatgtg gatattggcg aacctgatac cgagggatat gctatcactg     2400

accggggatc tgctcccatc tctatggggt tcagggcttc tgatgttgaa actgcagaag     2460

gaggggagat ccacgagctc ctgagactcc aatccagagg caacaacttt ccgaagcttg     2520

ggaaaactct caatgttcct ccgcccccgg accccggtag ggccagcact tccgggacac     2580

ccattaaaaa gggcacagac gcgagattag cctcatttgg aacggagatc gcgtctttat     2640

tgacaggtgg tgcaacccaa tgtgctcgaa agtcaccctc ggaaccatca gggccaggtg     2700

cacctgcggg gaatgtcccc gagtgtgtga gcaatgccgc actgatacag gagtggacac     2760

ccgaatctgg taccacaatc tccccgagat cccagaataa tgaagaaggg ggagactatt     2820

atgatgatga gctgttctct gatgtccaag atattaaaac agccttggcc aaaatacacg     2880

aggataatca gaagataatc tccaagctag aatcactgct gttattgaag ggagaagttg     2940

agtcaattaa gaagcagatc aacaggcaaa atatcagcat atccaccctg gaaggacacc     3000

tctcaagcat catgatcgcc attcctggac ttgggaagga tcccaacgac cccactgcag     3060

atgtcgaaat caatcccgac ttgaaaccca tcataggcag agattcaggc cgagcactgg     3120

ccgaagttct caagaaaccc gttgccagcc gacaactcca aggaatgaca aatggacgga     3180

ccagttccag aggacagctg ctgaaggaat ttcagctaaa gccgatcggg aaaaagatga     3240

gctcagccgt cgggtttgtt cctgacaccg gccctgcatc acgcagtgta atccgctcca     3300

ttataaaatc cagccggcta gaggaggatc ggaagcgtta cctgatgact ctccttgatg     3360

atatcaaagg agccaatgat cttgccaagt tccaccagat gctgatgaag ataataatga     3420

agtagctaca gctcaactta cctgccaacc ccatgccagt cgacccaact agcctaccct     3480

ccatcattgt tataaaaaac ttaggaacca ggtccacaca gccgccagcc catcaacgcg     3540

tacggcgcgc agcgcttaga cgtctcgcga tcgatactag tacaacctaa atccattata     3600

aaaaacttag gagcaaagtg attgcctccc aaggtccaca atgacagaga cctacgactt     3660

cgacaagtcg gcatgggaca tcaaagggtc gatcgctccg atacaaccca ccacctacag     3720

tgatggcagg ctggtgcccc aggtcagagt catagatcct ggtctaggcg acaggaagga     3780

tgaatgcttt atgtacatgt ttctgctggg ggttgttgag gacagcgatt ccctagggcc     3840

tccaatcggg cgagcatttg ggttcctgcc cttaggtgtt ggcagatcca cagcaaagcc     3900

cgaaaaactc ctcaaagagg ccactgagct tgacatagtt gttagacgta cagcagggct     3960

caatgaaaaa ctggtgttct acaacaacac cccactaact ctcctcacac cttggagaaa     4020

ggtcctaaca acagggagtg tcttcaacgc aaaccaagtg tgcaatgcgg ttaatctgat     4080

accgctcgat accccgcaga ggttccgtgt tgtttatatg agcatcaccc gtctttcgga     4140

taacgggtat tacaccgttc ctagaagaat gctggaattc agatcggtca atgcagtggc     4200

cttcaacctg ctggtgaccc ttaggattga caaggcgata ggccctggga agatcatcga     4260

caatacagag caacttcctg aggcaacatt tatggtccac atcgggaact tcaggagaaa     4320

gaagagtgaa gtctactctg ccgattattg caaaatgaaa atcgaaaaga tgggcctggt     4380

ttttgcactt ggtgggatag ggggcaccag tcttcacatt agaagcacag gcaaaatgag     4440

caagactctc catgcacaac tcgggttcaa gaagacctta tgttacccgc tgatggatat     4500

caatgaagac cttaatcgat tactctggag gagcagatgc aagatagtaa gaatccaggc     4560

agttttgcag ccatcagttc ctcaagaatt ccgcatttac gacgacgtga tcataaatga     4620

tgaccaagga ctattcaaag ttctgtagac cgtagtgccc agcaatgccc gaaaacgacc     4680

cccctcacaa tgacagccag aaggcccgga caaaaaagcc ccctccgaaa gactccacgg     4740

accaagcgag aggccagcca gcagccgacg gcaagcgcga acaccaggcg gccccagcac     4800

agaacagccc tgacacaagg ccaccaccag ccaccccaat ctgcatcctc ctcgtgggac     4860

ccccgaggac caacccccaa ggctgccccc gatccaaacc accaaccgca tccccaccac     4920

ccccgggaaa gaaaccccca gcaattggaa ggcccctccc cctcttcctc aacacaagaa     4980

ctccacaacc gaaccgcaca agcgaccgag gtgacccaac cgcaggcatc cgactcccta     5040

gacagatcct ctctccccgg caaactaaac aaaacttagg gccaaggaac atacacaccc     5100

aacagaaccc agaccccggc ccacggcgcc gcgcccccaa cccccgacaa ccagagggag     5160

cccccaacca atcccgccgg ctcccccggt gcccacaggc agggacacca acccccgaac     5220

agacccagca cccaaccatc gacaatccaa gacggggggg cccccccaaa aaaaggcccc     5280

caggggccga cagccagcac cgcgaggaag cccacccacc ccacacacga ccacggcaac     5340

caaaccagaa cccagaccac cctgggccac cagctcccag actcggccat caccccgcag     5400

aaaggaaagg ccacaacccg cgcaccccag ccccgatccg gcggggagcc acccaacccg     5460

aaccagcacc caagagcgat ccccgaagga cccccgaacc gcaaaggaca tcagtatccc     5520

acagcctctc caagtccccc ggtctcctcc tcttctcgaa gggaccaaaa gatcaatcca     5580

ccacacccga cgacactcaa ctccccaccc ctaaaggaga caccgggaat cccagaatca     5640

agactcatcc aatgtccatc atgggtctca aggtgaacgt ctctgccata ttcatggcag     5700

tactgttaac tctccaaaca cccaccggtc aaatccattg gggcaatctc tctaagatag     5760

gggtggtagg aataggaagt gcaagctaca aagttatgac tcgttccagc catcaatcat     5820

tagtcataaa attaatgccc aatataactc tcctcaataa ctgcacgagg gtagagattg     5880

cagaatacag gagactactg agaacagttt tggaaccaat tagagatgca cttaatgcaa     5940

tgacccagaa tataagaccg gttcagagtg tagcttcaag taggagacac aagagatttg     6000

cgggagtagt cctggcaggt gcggccctag gcgttgccac agctgctcag ataacagccg     6060

gcattgcact tcaccagtcc atgctgaact ctcaagccat cgacaatctg agagcgagcc     6120

tggaaactac taatcaggca attgagacaa tcagacaagc agggcaggag atgatattgg     6180

ctgttcaggg tgtccaagac tacatcaata atgagctgat accgtctatg aaccaactat     6240

cttgtgattt aatcggccag aagctcgggc tcaaattgct cagatactat acagaaatcc     6300

tgtcattatt tggccccagt ttacgggacc ccatatctgc ggagatatct atccaggctt     6360

tgagctatgc gcttggagga gacatcaata aggtgttaga aaagctcgga tacagtggag     6420

gtgatttact gggcatctta gagagcggag gaataaaggc ccggataact cacgtcgaca     6480

cagagtccta cttcattgtc ctcagtatag cctatccgac gctgtccgag attaaggggg     6540

tgattgtcca ccggctagag ggggtctcgt acaacatagg ctctcaagag tggtatacca     6600

ctgtgcccaa gtatgttgca acccaagggt accttatctc gaattttgat gagtcatcgt     6660

gtactttcat gccagagggg actgtgtgca gccaaaatgc cttgtacccg atgagtcctc     6720

tgctccaaga atgcctccgg gggtacacca agtcctgtgc tcgtacactc gtatccgggt     6780

cttttgggaa ccggttcatt ttatcacaag ggaacctaat agccaattgt gcatcaatcc     6840

tttgcaagtg ttacacaaca ggaacgatca ttaatcaaga ccctgacaag atcctaacat     6900

acattgctgc cgatcactgc ccggtagtcg aggtgaacgg cgtgaccatc caagtcggga     6960

gcaggaggta tccagacgct gtgtacttgc acagaattga cctcggtcct cccatatcat     7020

tggagaggtt ggacgtaggg acaaatctgg ggaatgcaat tgctaagttg gaggatgcca     7080

aggaattgtt ggagtcatcg gaccagatat tgaggagtat gaaaggttta tcgagcacta     7140

gcatagtcta catcctgatt gcagtgtgtc ttggagggtt gatagggatc cccgctttaa     7200

tatgttgctg cagggggcgt tgtaacaaaa agggagaaca agttggtatg tcaagaccag     7260

gcctaaagcc tgatcttacg ggaacatcaa aatcctatgt aaggtcgctc tgatcctcta     7320

caactcttga aacacaaatg tcccacaagt ctcctcttcg tcatcaagca accaccgcac     7380

ccagcatcaa gcccacctga aattatctcc ggcttccctc tggccgaaca atatcggtag     7440

ttaatcaaaa cttagggtgc aagatcatcc acaatgtcac cacaacgaga ccggataaat     7500

gccttctaca aagataaccc ccatcccaag ggaagtagga tagtcattaa cagagaacat     7560

cttatgattg atagacctta tgttttgctg gctgttctgt ttgtcatgtt tctgagcttg     7620

atcgggttgc tagccattgc aggcattaga cttcatcggg cagccatcta caccgcagag     7680

atccataaaa gcctcagcac caatctagat gtaactaact caatcgagca tcaggtcaag     7740

gacgtgctga caccactctt caaaatcatc ggtgatgaag tgggcctgag gacacctcag     7800

agattcactg acctagtgaa attaatctct gacaagatta aattccttaa tccggatagg     7860

gagtacgact tcagagatct cacttggtgt atcaacccgc cagagagaat caaattggat     7920

tatgatcaat actgtgcaga tgtggctgct gaagagctca tgaatgcatt ggtgaactca     7980

actctactgg agaccagaac aaccaatcag ttcctagctg tctcaaaggg aaactgctca     8040

gggcccacta caatcagagg tcaattctca aacatgtcgc tgtccctgtt agacttgtat     8100

ttaggtcgag gttacaatgt gtcatctata gtcactatga catcccaggg aatgtatggg     8160

ggaacttacc tagtggaaaa gcctaatctg agcagcaaaa ggtcagagtt gtcacaactg     8220

agcatgtacc gagtgtttga agtaggtgtt atcagaaatc cgggtttggg ggctccggtg     8280

ttccatatga caaactatct tgagcaacca gtcagtaatg atctcagcaa ctgtatggtg     8340

gctttggggg agctcaaact cgcagccctt tgtcacgggg aagattctat cacaattccc     8400

tatcagggat cagggaaagg tgtcagcttc cagctcgtca agctaggtgt ctggaaatcc     8460

ccaaccgaca tgcaatcctg ggtcccctta tcaacggatg atccagtgat agacaggctt     8520

tacctctcat ctcacagagg tgttatcgct gacaatcaag caaaatgggc tgtcccgaca     8580

acacgaacag atgacaagtt gcgaatggag acatgcttcc aacaggcgtg taagggtaaa     8640

atccaagcac tctgcgagaa tcccgagtgg gcaccattga aggataacag gattccttca     8700

tacggggtct tgtctgttga tctgagtctg acagttgagc ttaaaatcaa aattgcttcg     8760

ggattcgggc cattgatcac acacggttca gggatggacc tatacaaatc caaccacaac     8820

aatgtgtatt ggctgactat cccgccaatg aagaacctag ccttaggtgt aatcaacaca     8880

ttggagtgga taccgagatt caaggttagt ccctacctct tcactgtccc aattaaggaa     8940

gcaggcgaag actgccatgc cccaacatac ctacctgcgg aggtggatgg tgatgtcaaa     9000

ctcagttcca atctggtgat tctacctggt caagatctcc aatatgtttt ggcaacctac     9060

gatacttcca gggttgaaca tgctgtggtt tattacgttt acagcccaag ccgctcattt     9120

tcttactttt atccttttag gttgcctata aagggggtcc ccatcgaatt acaagtggaa     9180

tgcttcacat gggaccaaaa actctggtgc cgtcacttct gtgtgcttgc ggactcagaa     9240

tctggtggac atatcactca ctctgggatg gtgggcatgg gagtcagctg cacagtcacc     9300

cgggaagatg gaaccaatcg cagatagggc tgctagtgaa ccaatcacat gatgtcaccc     9360

agacatcagg catacccact agtgtgaaat agacatcaga attaagaaaa acgtagggtc     9420

caagtggttc cccgttatgg actcgctatc tgtcaaccag atcttatacc ctgaagttca     9480

cctagatagc ccgatagtta ccaataagat agtagccatc ctggagtatg ctcgagtccc     9540

tcacgcttac agcctggagg accctacact gtgtcagaac atcaagcacc gcctaaaaaa     9600

cggattttcc aaccaaatga ttataaacaa tgtggaagtt gggaatgtca tcaagtccaa     9660

gcttaggagt tatccggccc actctcatat tccatatcca aattgtaatc aggatttatt     9720

taacatagaa gacaaagagt caacgaggaa gatccgtgaa ctcctcaaaa aggggaattc     9780

gctgtactcc aaagtcagtg ataaggtttt ccaatgctta agggacacta actcacggct     9840

tggcctaggc tccgaattga gggaggacat caaggagaaa gttattaact tgggagttta     9900

catgcacagc tcccagtggt ttgagccctt tctgttttgg tttacagtca agactgagat     9960

gaggtcagtg attaaatcac aaacccatac ttgccatagg aggagacaca cacctgtatt    10020

cttcactggt agttcagttg agttgctaat ctctcgtgac cttgttgcta taatcagtaa    10080

agagtctcaa catgtatatt acctgacatt tgaactggtt ttgatgtatt gtgatgtcat    10140

agaggggagg ttaatgacag agaccgctat gactattgat gctaggtata cagagcttct    10200

aggaagagtc agatacatgt ggaaactgat agatggtttc ttccctgcac tcgggaatcc    10260

aacttatcaa attgtagcca tgctggagcc tctttcactt gcttacctgc agctgaggga    10320

tataacagta gaactcagag gtgctttcct taaccactgc tttactgaaa tacatgatgt    10380

tcttgaccaa aacgggtttt ctgatgaagg tacttatcat gagttaactg aagctctaga    10440

ttacattttc ataactgatg acatacatct gacaggggag attttctcat ttttcagaag    10500

tttcggccac cccagacttg aagcagtaac ggctgctgaa aatgttagga aatacatgaa    10560

tcagcctaaa gtcattgtgt atgagactct gatgaaaggt catgccatat tttgtggaat    10620

cataatcaac ggctatcgtg acaggcacgg aggcagttgg ccaccgctga ccctccccct    10680

gcatgctgca gacacaatcc ggaatgctca agcttcaggt gaagggttaa cacatgagca    10740

gtgcgttgat aactggaaat cttttgctgg agtgaaattt ggctgcttta tgcctcttag    10800

cctggatagt gatctgacaa tgtacctaaa ggacaaggca cttgctgctc tccaaaggga    10860

atgggattca gtttacccga aagagttcct gcgttacgac cctcccaagg gaaccgggtc    10920

acggaggctt gtagatgttt tccttaatga ttcgagcttt gacccatatg atgtgataat    10980

gtatgttgta agtggagctt acctccatga ccctgagttc aacctgtctt acagcctgaa    11040

agaaaaggag atcaaggaaa caggtagact ttttgctaaa atgacttaca aaatgagggc    11100

atgccaagtg attgctgaaa atctaatctc aaacgggatt ggcaaatatt ttaaggacaa    11160

tgggatggcc aaggatgagc acgatttgac taaggcactc cacactctag ctgtctcagg    11220

agtccccaaa gatctcaaag aaagtcacag gggggggcca gtcttaaaaa cctactcccg    11280

aagcccagtc cacacaagta ccaggaacgt gagagcagca aaagggttta tagggttccc    11340

tcaagtaatt cggcaggacc aagacactga tcatccggag aatatggaag cttacgagac    11400

agtcagtgca tttatcacga ctgatctcaa gaagtactgc cttaattgga gatatgagac    11460

catcagcttg tttgcacaga ggctaaatga gatttacgga ttgccctcat ttttccagtg    11520

gctgcataag aggcttgaga cctctgtcct gtatgtaagt gaccctcatt gcccccccga    11580

ccttgacgcc catatcccgt tatataaagt ccccaatgat caaatcttca ttaagtaccc    11640

tatgggaggt atagaagggt attgtcagaa gctgtggacc atcagcacca ttccctatct    11700

atacctggct gcttatgaga gcggagtaag gattgcttcg ttagtgcaag gggacaatca    11760

gaccatagcc gtaacaaaaa gggtacccag cacatggccc tacaacctta agaaacggga    11820

agctgctaga gtaactagag attactttgt aattcttagg caaaggctac atgatattgg    11880

ccatcacctc aaggcaaatg agacaattgt ttcatcacat ttttttgtct attcaaaagg    11940

aatatattat gatgggctac ttgtgtccca atcactcaag agcatcgcaa gatgtgtatt    12000

ctggtcagag actatagttg atgaaacaag ggcagcatgc agtaatattg ctacaacaat    12060

ggctaaaagc atcgagagag gttatgaccg ttaccttgca tattccctga acgtcctaaa    12120

agtgatacag caaattctga tctctcttgg cttcacaatc aattcaacca tgacccggga    12180

tgtagtcata cccctcctca caaacaacga cctcttaata aggatggcac tgttgcccgc    12240

tcctattggg gggatgaatt atctgaatat gagcaggctg tttgtcagaa acatcggtga    12300

tccagtaaca tcatcaattg ctgatctcaa gagaatgatt ctcgcctcac taatgcctga    12360

agagaccctc catcaagtaa tgacacaaca accgggggac tcttcattcc tagactgggc    12420

tagcgaccct tactcagcaa atcttgtatg tgtccagagc atcactagac tcctcaagaa    12480

cataactgca aggtttgtcc tgatccatag tccaaaccca atgttaaaag gattattcca    12540

tgatgacagt aaagaagagg acgagggact ggcggcattc ctcatggaca ggcatattat    12600

agtacctagg gcagctcatg aaatcctgga tcatagtgtc acaggggcaa gagagtctat    12660

tgcaggcatg ctggatacca caaaaggctt gattcgagcc agcatgagga agggggggtt    12720

aacctctcga gtgataacca gattgtccaa ttatgactat gaacaattca gagcagggat    12780

ggtgctattg acaggaagaa agagaaatgt cctcattgac aaagagtcat gttcagtgca    12840

gctggcgaga gctctaagaa gccatatgtg ggcgaggcta gctcgaggac ggcctattta    12900

cggccttgag gtccctgatg tactagaatc tatgcgaggc caccttattc ggcgtcatga    12960

gacatgtgtc atctgcgagt gtggatcagt caactacgga tggttttttg tcccctcggg    13020

ttgccaactg gatgatattg acaaggaaac atcatccttg agagtcccat atattggttc    13080

taccactgat gagagaacag acatgaagct tgccttcgta agagccccaa gtcgatcctt    13140

gcgatctgct gttagaatag caacagtgta ctcatgggct tacggtgatg atgatagctc    13200

ttggaacgaa gcctggttgt tggctaggca aagggccaat gtgagcctgg aggagctaag    13260

ggtgatcact cccatctcaa cttcgactaa tttagcgcat aggttgaggg atcgtagcac    13320

tcaagtgaaa tactcaggta catcccttgt ccgagtggcg aggtatacca caatctccaa    13380

cgacaatctc tcatttgtca tatcagataa gaaggttgat actaacttta tataccaaca    13440

aggaatgctt ctagggttgg gtgttttaga aacattgttt cgactcgaga aagataccgg    13500

atcatctaac acggtattac atcttcacgt cgaaacagat tgttgcgtga tcccgatgat    13560

agatcatccc aggataccca gctcccgcaa gctagagctg agggcagagc tatgtaccaa    13620

cccattgata tatgataatg cacctttaat tgacagagat gcaacaaggc tatacaccca    13680

gagccatagg aggcaccttg tggaatttgt tacatggtcc acaccccaac tatatcacat    13740

tttagctaag tccacagcac tatctatgat tgacctggta acaaaatttg agaaggacca    13800

tatgaatgaa atttcagctc tcatagggga tgacgatatc aatagtttca taactgagtt    13860

tctgctcata gagccaagat tattcactat ctacttgggc cagtgtgcgg ccatcaattg    13920

ggcatttgat gtacattatc atagaccatc agggaaatat cagatgggtg agctgttgtc    13980

atcgttcctt tctagaatga gcaaaggagt gtttaaggtg cttgtcaatg ctctaagcca    14040

cccaaagatc tacaagaaat tctggcattg tggtattata gagcctatcc atggtccttc    14100

acttgatgct caaaacttgc acacaactgt gtgcaacatg gtttacacat gctatatgac    14160

ctacctcgac ctgttgttga atgaagagtt agaagagttc acatttctct tgtgtgaaag    14220

cgacgaggat gtagtaccgg acagattcga caacatccag gcaaaacact tatgtgttct    14280

ggcagatttg tactgtcaac cagggacctg cccaccaatt cgaggtctaa gaccggtaga    14340

gaaatgtgca gttctaaccg accatatcaa ggcagaggct atgttatctc cagcaggatc    14400

ttcgtggaac ataaatccaa ttattgtaga ccattactca tgctctctga cttatctccg    14460

gcgaggatcg atcaaacaga taagattgag agttgatcca ggattcattt tcgacgccct    14520

cgctgaggta aatgtcagtc agccaaagat cggcagcaac aacatctcaa atatgagcat    14580

caaggctttc agacccccac acgatgatgt tgcaaaattg ctcaaagata tcaacacaag    14640

caagcacaat cttcccattt cagggggcaa tctcgccaat tatgaaatcc atgctttccg    14700

cagaatcggg ttgaactcat ctgcttgcta caaagctgtt gagatatcaa cattaattag    14760

gagatgcctt gagccagggg aggacggctt gttcttgggt gagggatcgg gttctatgtt    14820

gatcacttat aaagagatac ttaaactaaa caagtgcttc tataatagtg gggtttccgc    14880

caattctaga tctggtcaaa gggaattagc accctatccc tccgaagttg gccttgtcga    14940

acacagaatg ggagtaggta atattgtcaa agtgctcttt aacgggaggc ccgaagtcac    15000

gtgggtaggc agtgtagatt gcttcaattt catagttagt aatatcccta cctctagtgt    15060

ggggtttatc cattcagata tagagacctt gcctgacaaa gatactatag agaagctaga    15120

ggaattggca gccatcttat cgatggctct gctcctgggc aaaataggat caatactggt    15180

gattaagctt atgcctttca gcggggattt tgttcaggga tttataagtt atgtagggtc    15240

tcattataga gaagtgaacc ttgtataccc tagatacagc aacttcatct ctactgaatc    15300

ttatttggtt atgacagatc tcaaggctaa ccggctaatg aatcctgaaa agattaagca    15360

gcagataatt gaatcatctg tgaggacttc acctggactt ataggtcaca tcctatccat    15420

taagcaacta agctgcatac aagcaattgt gggagacgca gttagtagag gtgatatcaa    15480

tcctactctg aaaaaactta cacctataga gcaggtgctg atcaattgcg ggttggcaat    15540

taacggacct aagctgtgca aagaattgat ccaccatgat gttgcctcag ggcaagatgg    15600

attgcttaat tctatactca tcctctacag ggagttggca agattcaaag acaaccaaag    15660

aagtcaacaa gggatgttcc acgcttaccc cgtattggta agtagcaggc aacgagaact    15720

tatatctagg atcacccgca aattctgggg gcacattctt ctttactccg ggaacaaaaa    15780

gttgataaat aagtttatcc agaatctcaa gtccggctat ctgatactag acttacacca    15840

gaatatcttc gttaagaatc tatccaagtc agagaaacag attattatga cggggggttt    15900

gaaacgtgag tgggttttta aggtaacagt caaggagacc aaagaatggt ataagttagt    15960

cggatacagt gccctgatta aggactaatt ggttgaactc cggaacccta atcctgccct    16020

aggtggttag gcattatttg caatatatta aagaaaactt tgaaaatacg aagtttctat    16080

tcccagcttt gtctggtggc cggcatggtc ccagcctcct cgctggcgcc ggctgggcaa    16140

cattccgagg ggaccgtccc ctcggtaatg gcgaatggga cgcggccgat ccggctgcta    16200

acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctagcataac    16260

cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga actatatccg    16320

gatgcggccg cgggccctat ggtacccagc ttttgttccc tttagtgagg gttaattccg    16380

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt    16440

ccacacaaca taggagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagg    16500

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc    16560

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct    16620

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca    16680

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac    16740

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt    16800

ttccataggc tcggcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg    16860

cgaaacccga caggactata aagataccag gcgttccccc ctggaagctc cctcgtgcgc    16920

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc    16980

gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc    17040

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac    17100

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt    17160

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct    17220

aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc    17280

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt    17340

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg    17400

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc    17460

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa    17520

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag    17580

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact gcccgtcgtg    17640

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga    17700

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag    17760

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa    17820

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc    17880

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca    17940

aggcgagtta catgatcccc catgttgtga aaaaaagcgg ttagctcctt cggtcctccg    18000

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tgcttatggc agcactgcat    18060

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc    18120

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg    18180

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg    18240

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt    18300

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca    18360

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata    18420

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac    18480

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa    18540

gtgccacctg aaattgtaaa cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa    18600

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa    18660

tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac    18720

gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa    18780

ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct    18840

aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa    18900

gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc    18960

gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtccca ttcgccattc    19020

aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt acgccagcca    19080

ccgcggtgat ccttataaag ctagatg                                        19107


<210>  61
<211>  591
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein encoded by SEQ ID NO: 53

<400>  61

Arg Arg Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr 
1               5                   10                  15      


Thr Ala Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
            20                  25                  30          


Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr 
        35                  40                  45              


Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met 
    50                  55                  60                  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
65                  70                  75                  80  


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
                85                  90                  95      


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
            100                 105                 110         


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
        115                 120                 125             


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg 
    130                 135                 140                 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala 
145                 150                 155                 160 


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
                165                 170                 175     


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
            180                 185                 190         


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
        195                 200                 205             


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
    210                 215                 220                 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
225                 230                 235                 240 


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
                245                 250                 255     


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
            260                 265                 270         


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
        275                 280                 285             


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
    290                 295                 300                 


Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
305                 310                 315                 320 


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
                325                 330                 335     


Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg 
            340                 345                 350         


Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
        355                 360                 365             


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
    370                 375                 380                 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
385                 390                 395                 400 


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
                405                 410                 415     


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
            420                 425                 430         


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
        435                 440                 445             


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
    450                 455                 460                 


Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg 
465                 470                 475                 480 


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
                485                 490                 495     


Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly 
            500                 505                 510         


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
        515                 520                 525             


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
    530                 535                 540                 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
545                 550                 555                 560 


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
                565                 570                 575     


Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser 
            580                 585                 590     


<210>  62
<211>  692
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein encoded by SEQ ID NOs: 54

<400>  62

Arg Arg Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr 
1               5                   10                  15      


Thr Ala Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
            20                  25                  30          


Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr 
        35                  40                  45              


Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met 
    50                  55                  60                  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
65                  70                  75                  80  


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
                85                  90                  95      


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
            100                 105                 110         


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
        115                 120                 125             


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg 
    130                 135                 140                 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala 
145                 150                 155                 160 


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
                165                 170                 175     


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
            180                 185                 190         


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
        195                 200                 205             


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
    210                 215                 220                 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
225                 230                 235                 240 


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
                245                 250                 255     


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
            260                 265                 270         


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
        275                 280                 285             


Trp Gly Asn Gly Cys Gly Asp Phe Gly Lys Gly Ser Leu Val Thr Cys 
    290                 295                 300                 


Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
305                 310                 315                 320 


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
                325                 330                 335     


Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg 
            340                 345                 350         


Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
        355                 360                 365             


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
    370                 375                 380                 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
385                 390                 395                 400 


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
                405                 410                 415     


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
            420                 425                 430         


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
        435                 440                 445             


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
    450                 455                 460                 


Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg 
465                 470                 475                 480 


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
                485                 490                 495     


Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly 
            500                 505                 510         


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
        515                 520                 525             


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
    530                 535                 540                 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
545                 550                 555                 560 


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
                565                 570                 575     


Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly 
            580                 585                 590         


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
        595                 600                 605             


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
    610                 615                 620                 


Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
625                 630                 635                 640 


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
                645                 650                 655     


Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
            660                 665                 670         


Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile Phe Leu Ser Thr 
        675                 680                 685             


Ala Val Ser Ala 
    690         


<210>  63
<211>  1209
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sE antigen no codon optimization

<400>  63
atcaggtgca taggagtcag caatagggac tttgtggaag gtatgtcagg tgggacctgg       60

gttgatgttg tcttggaaca tggaggttgt gtcaccgtaa tggcacagga caaaccgact      120

gtcgacatag agctggttac aacaacagtc agcaacatgg cggaggtaag atcctactgc      180

tatgaggcat caatatcaga catggcttcg gacagccgct gcccaacaca aggtgaagcc      240

taccttgaca agcaatcaga cactcaatat gtctgcaaaa gaacgttagt ggacagaggc      300

tggggaaatg gatgtggact ttttggcaaa gggagcctgg tgacatgcgc taagtttgca      360

tgctccaaga aaatgaccgg gaagagcatc cagccagaga atctggagta ccggataatg      420

ctgtcagttc atggctccca gcacagtggg atgattgtta atgacacagg acatgaaact      480

gatgagaata gagcgaaagt tgagataacg cccaattcac caagagccga agccaccctg      540

gggggttttg gaagcctagg acttgattgt gaaccgagga caggccttga cttttcagat      600

ttgtattact tgactatgaa taacaagcac tggttggttc acaaggagtg gttccacgac      660

attccattac cttggcacgc tggggcagac accggaactc cacactggaa caacaaagaa      720

gcactggtag agttcaagga cgcacatgcc aaaaggcaaa ctgtcgtggt tctagggagt      780

caagaaggag cagttcacac ggcccttgct ggagctctgg aggctgagat ggatggtgca      840

aagggaaggc tgtcctctgg ccacttgaaa tgtcgcctga aaatggataa acttagattg      900

aagggcgtgt catactcctt gtgtactgca gcgttcacat tcaccaagat cccggctgaa      960

acactgcacg ggacagtcac agtggaggta cagtacgcag ggacagatgg accttgcaag     1020

gttccagctc agatggcggt ggacatgcaa actctgaccc cagttgggag gttgataacc     1080

gctaaccccg taatcactga aagcactgag aactctaaga tgatgctgga acttgatcca     1140

ccatttgggg actcttacat tgtcatagga gtcggggaga agaagatcac ccaccactgg     1200

cacaggagt                                                             1209


<210>  64
<211>  1209
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sE antigen codon optimization (human)

<400>  64
atcagatgca tcggagtttc caatcgtgac tttgtcgaag ggatgtccgg aggcacctgg       60

gttgacgtgg tgcttgagca tggtggctgc gtaacggtaa tggctcagga caaacccacg      120

gttgacatag aactggtgac cacgactgtc agtaatatgg ccgaagtgcg aagctactgc      180

tatgaggcct ctatctctga catggcatca gacagccggt gtccaactca aggcgaagct      240

tatctggaca agcaatccga tacacagtac gtgtgcaagc ggactctcgt ggatagaggt      300

tggggcaatg ggtgtggtct gtttgggaaa ggcagtctgg taacatgcgc aaagttcgca      360

tgttccaaga aaatgacagg aaagagcatt cagccggaaa atctggagta taggattatg      420

ctcagcgtgc atgggagcca gcacagtggc atgattgtca atgatacagg ccacgaaacc      480

gacgagaaca gagcgaaggt tgagatcact cccaattcac ctcgcgcaga ggccactctg      540

ggagggtttg gaagtctcgg tctggactgt gaacctcgca ctggcctgga cttcagcgat      600

ctgtattacc tgacgatgaa caacaagcat tggctggtcc ataaggagtg gttccatgat      660

attccgcttc cttggcatgc cggagccgat accggaacac cccactggaa caacaaagag      720

gctttggtgg agttcaaaga tgcacacgct aagcgccaaa ccgtcgtggt cctgggtagc      780

caagaaggag cggttcacac tgcgcttgcc ggagccctgg aggcggaaat ggatggggcc      840

aaagggcgcc tttccagtgg acacctgaag tgtcggctga aaatggacaa gctgagactg      900

aaaggtgtgt cttacagcct gtgcaccgca gccttcactt tcaccaaaat ccctgctgaa      960

accttgcacg gaacagtgac agtagaggtg cagtatgcag gcacagatgg cccatgtaag     1020

gtgccagctc agatggcagt ggacatgcag accctgactc cagtgggaag gctcataact     1080

gccaatccgg tcatcacaga gtctaccgag aactcaaaga tgatgctgga gctggaccct     1140

ccctttgggg actcttacat agtcataggg gtaggcgaga agaaaatcac ccatcactgg     1200

cacaggagc                                                             1209


<210>  65
<211>  403
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sE antigen L107D

<400>  65

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Asp Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  66
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E antigen L107D

<400>  66

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Asp Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  67
<211>  10272
<212>  DNA
<213>  Zika virus isolate GD01 polyprotein gene, complete cds

<400>  67
atgaaaaacc caaaaaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt      120

catgggccca tcaggatggt cttggcgatt ctagcctttt tgagattcac ggcaatcaag      180

ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag      300

aagaagagac gaggcgcaga aactagtgtc ggaattgttg gcctcctgct gaccacagct      360

atggcagcgg aggtcactag acgtgggagt gcatactata tgtacttgga cagaaacgat      420

gctggggagg ccatatcttt tccaaccaca ttggggatga ataagtgtta tatacagatc      480

atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gctggatgag      540

ggggtggaac cagatgacgt cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac      600

ggaacctgcc atcacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctccct      660

tcccattcca ctaggaagct gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac      720

acaaagcact tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca      780

gcagctgcta tcgcttggct tttgggaagc tcaacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac      900

tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt      960

gtcaccgtaa tggcacagga caaaccgact gtcgacatag agctggttac aacaacagtc     1020

agcaacatgg cggaggtaag atcctactgc tatgaggcat caatatcaga catggcttcg     1080

gacagccgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa     1200

gggagcctgg tgacatgcgc taagtttgca tgctccaaga aaatgaccgg gaaaagcatc     1260

cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg     1320

atgattgtta atggcacagg acatgaaact gatgagaata gagcgaaagt tgagataacg     1380

cccaattcac caagagccga agccaccctg gggggttttg gaagcctagg acttgattgt     1440

gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac     1500

tggttggttc acaaggagtg gttccacgac attccattac cttggcacgc tggggcagac     1560

accggaactc cacactggaa caacaaagaa gcactggtag agttcaagga cgcacatgcc     1620

aaaaggcaaa ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct     1680

ggagctctgg aggctgagat ggatggagca aagggaaggc tgtcctctgg ccacttgaaa     1740

tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtactgca     1800

gcgttcacat tcaccaagat cccggctgaa acactgcacg ggacagtcac agtggaggta     1860

cagtacgcag ggacagatgg accttgcaag gttccagctc agatggcggt ggacatgcaa     1920

actctgaccc cagttgggag gttgataacc gctaaccccg taatcactga aagcactgag     1980

aactctaaga tgatgctgga acttgatcca ccatttgggg actcttacat tgtcatagga     2040

gtcggggaga agaagatcac ccaccactgg cacaggagtg gcagcaccat tggaaaagca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggac     2160

tttggatcag ttggaggcgc tctcaactca ttgggcaagg gcatccatca aatttttgga     2220

gcagctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg     2280

ttgctgatgt ggttgggtct gaacacaaag aatggatcta tttcccttat gtgcttggcc     2340

ttagggggag tgttgatctt cttatccaca gccgtctctg ctgatgtggg gtgctcggtg     2400

gacttctcaa agaaggagac gagatgcggt acaggggtgt ttgtctataa cgacgttgaa     2460

gcctggaggg acaggtacaa gtaccatcct gactcccccc gtagattggc agcagcagtc     2520

aagcaagcct gggaagatgg tatctgcggg atctcctctg tttcaagaat ggaaaacatc     2580

atgtggagat cagtagaagg ggagctcaac gcaatcctgg aagagaatgg agttcaactg     2640

acggtcgttg tgggatctgt aaaaaacccc atgtggagag gtccacagag attgcccgtg     2700

cctgtgaacg agctgcccca cggctggaag gcttggggga aatcgtactt cgtcagagca     2760

gcaaagacaa ataacagctt tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa     2820

catagagcat ggaacagctt tcttgtggag gatcatgggt tcggggtatt tcacactagt     2880

gtctggctca aggttagaga agactattca ttagagtgtg atccagccgt tattggaaca     2940

gctgttaagg gaaaggaggc tgtacacagt gatctaggct actggattga gagtgagaag     3000

aatgacacat ggaggctgaa gagggcccat ctgatcgaga tgaaaacatg tgaatggcca     3060

aagtcccaca cattgtggac agatggaata gaagagagtg atctgatcat acccaagtct     3120

ttagctgggc cactcagcca tcacaatacc agagagggct acaggaccca aatgaaaggg     3180

ccatggcaca gtgaggagct tgaaattcgg tttgaggaat gcccaggcac taaggtccac     3240

gtggaggaaa catgtggaac aagaggacca tctctgagat caaccactgc aagcggaagg     3300

gtgatcgagg aatggtgctg cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa     3360

gatggctgtt ggtatggaat ggagataagg cccaggaaag aaccagaaag caacttagta     3420

aggtcaatgg tgactgcagg atcaactgat cacatggacc acttctccct tggagtgctt     3480

gtgatcctgc tcatggtgca ggaagggctg aagaagagaa tgaccacaaa gatcatcata     3540

agcacatcaa tggcagtgct ggtagctatg atcctgggag gattttcaat gagtgacctg     3600

gctaagcttg caattttgat gggtgccacc ttcgcggaaa tgaacactgg aggagatgta     3660

gctcatctgg cgctgatagc ggcattcaaa gtcagaccag cgttgctggt atctttcatc     3720

ttcagagcta attggacacc ccgtgaaagc atgctgctgg ccttggcctc gtgtcttttg     3780

caaactgcga tctccgcctt ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg     3840

gcctggttgg cagtacgagc gatggttgtt ccacgcactg ataacatcac cttagcaatc     3900

ctggctgctc tgacaccact ggcccggggc acactgcttg tggcgtggag agcaggcctt     3960

gctacttgcg gggggtttat gctcctctct ctgaagggaa aaggcagtgt gaagaagaac     4020

ttaccatttg tcatggccct gggactaacc gctgtgaggc tggtcgaccc catcaacgtg     4080

gtgggactgc tgttgctcac aaggagtggg aagcggagct ggccccctag cgaagtactc     4140

acagctgttg gcctgatatg cgcattggct ggagggttcg ccaaggcaga tatagagatg     4200

gctgggccca tggccgcggt cggtctgcta attgtcagtt acgtggtctc aggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaagatgc ggaagtcact     4320

ggaaacagtc cccggctcga tgtggcgcta gatgagagtg gtgatttctc cctggtggag     4380

gatgacggtc cccccatgag agagatcata ctcaaggtgg tcctgatgac catctgtggc     4440

atgaacccaa tagccatacc ctttgcagct ggagcgtggt acgtatacgt gaagactgga     4500

aaaaggagtg gtgctctatg ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc     4560

acagatggag tgtacagagt aatgactcgc agactgctag gttcaacaca agttggagtg     4620

ggagttatgc aagagggggt ctttcacact atgtggcacg tcacaaaagg atccgcgctg     4680

agaagcggtg aagggagact tgatccatac tggggagatg tcaagcagga tctggtgtca     4740

tactgtggtc catggaagct agatgccgcc tgggacgggc acagcgaggt gcagctcttg     4800

gccgtgcccc ccggagagag agcgaggaac atccagactc tgcccggaat atttaagaca     4860

aaggatgggg acattggagc ggttgcgctg gattacccag caggaacttc aggatctcca     4920

atcctagaca agtgtgggag agtgatagga ctttatggca atggggtcgt gatcaaaaat     4980

gggagttatg ttagtgccat cacccaaggg aggagggagg aagagactcc tgttgagtgc     5040

ttcgagcctt cgatgctgaa gaagaagcag ctaactgtct tagacttgca tcctggagct     5100

gggaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaac aagactccgt     5160

actgtgatct tagctccaac cagggttgtc gctgctgaaa tggaggaggc ccttagaggg     5220

cttccagtgc gttatatgac aacagcagtc aatgtcaccc actctggaac agaaatcgtc     5280

gacttaatgt gccatgccac cttcacttca cgtctactac agccaattag agtccccaac     5340

tataatctgt atattatgga tgaggcccac ttcacagatc cctcaagtat agcagcaaga     5400

ggatacattt caacaagggt tgagatgggc gaggcggctg ccatcttcat gaccgccacg     5460

ccaccaggaa cccgtgacgc atttccggac tccaactcac caattatgga caccgaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacggatca ttctggaaaa     5580

acagtttggt ttgttccaag cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag     5640

gctggaaaac gggtcataca gctcagcaga aagacttttg agacagagtt ccagaaaaca     5700

aaacatcaag agtgggactt tgtcgtgaca actgacattt cagagatggg cgccaacttt     5760

aaagctgacc gtgtcataga ttccaggaga tgcctaaagc cggtcatact tgatggcgag     5820

agagtcattc tggctggacc catgcctgtc acacatgcca gcgctgccca gaggaggggg     5880

cgcataggca ggaatcccaa caaacctgga gatgagtatc tgtatggagg tgggtgcgca     5940

gagactgacg aagaccatgc acactggctt gaagcaagaa tgctccttga caatatttac     6000

ctccaagatg gcctcatagc ctcgctctat cgacctgagg ccgacaaagt agcagccatt     6060

gagggagagt tcaagcttag gacggagcaa aggaagacct ttgtggaact catgaaaaga     6120

ggagatcttc ctgtttggct ggcctatcag gttgcatctg ccggaataac ctacacagat     6180

agaagatggt gctttgatgg cacgaccaac aacaccataa tggaagacag tgtgccggca     6240

gaggtgtgga ccagacacgg agagaaaaga gtgctcaaac cgaggtggat ggacgccaga     6300

gtttgttcag atcatgcggc cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga     6360

gcggcttttg gagtgatgga agccctggga acactgccag gacacatgac agagagattc     6420

caggaagcca ttgacaacct cgctgtgctc atgcgggcag agactggaag caggccttac     6480

aaagccgcgg cagcccaatt gccggagacc ctagagacca ttatgctttt ggggttgctg     6540

ggaacagtct cgctgggaat cttcttcgtc ttgatgagga acaagggcat agggaagatg     6600

ggctttggaa tggtgactct tggggccagc gcatggctca tgtggctctc ggaaattgag     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgttcctat tgctggtggt gctcatacct     6720

gagccagaaa agcaaagatc tccccaggac aaccaaatgg caatcatcat catggtagca     6780

gtaggtcttc tgggcttgat taccgccaat gaactcggat ggttggagag aacaaagagt     6840

gacctaagcc atctaatggg aaggagagag gagggggcaa ccataggatt ctcaatggac     6900

attgacctgc ggccagcctc agcttgggcc atctatgctg ccttgacaac tttcattacc     6960

ccagccgtcc aacatgcagt gaccacctca tacaacaact actccttaat ggcgatggcc     7020

acgcaagctg gagtgttgtt tggtatgggc aaagggatgc cattctacgc atgggacttt     7080

ggagtcccgc tgctaatgat aggctgctac tcacaattaa cacccctgac cctaatagtg     7140

gccatcattt tgctcgtggc gcactacatg tacttgatcc cagggctgca ggcagcagct     7200

gcgcgtgctg cccagaagag aacggcagct ggcatcatga agaaccctgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa aaagatggga     7320

caggtgctac tcatagcagt agccgtctcc agcgccatac tgtcgcggac cgcctggggg     7380

tggggggagg ctggggccct gatcacagcc gcaacttcca ctttgtggga aggctctccg     7440

aacaagtact ggaactcctc tacagccact tcactgtgta acatttttag gggaagttac     7500

ttggctggag cttctctaat ctacacagta acaagaaacg ctggcttggt caagagacgt     7560

gggggtggaa caggagagac cctgggagag aaatggaagg cccgcttgaa ccagatgtcg     7620

gccctggagt tctactccta caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc     7680

cgccgcgccc tcaaggacgg tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca     7740

aagctgagat ggttggtgga gcggggatac ctgcagccct atggaaaggt cattgatctt     7800

ggatgtggca gagggggctg gagttactac gccgccacca tccgcaaagt tcaagaagtg     7860

aaaggataca caaaaggagg ccctggtcat gaagaacccg tgttggtgca aagctatggg     7920

tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt     7980

gacacgttgc tgtgtgacat aggtgagtca tcatctagtc ctgaagtgga agaagcacgg     8040

acgctcagag tcctctccat ggtgggggat tggcttgaaa aaagaccagg agccttttgt     8100

ataaaggtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt     8160

aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac     8220

tgggtctctg gagcgaaaag caacatcata aaaagtgtgt ccaccacgag ccagctcctc     8280

ttggggcgca tggacgggcc taggaggcca gtgaaatatg aggaggatgt gaatctcggc     8340

tctggcacgc gggctgtggc aagctgcgct gaagctccca acatgaagat cattggtaac     8400

cgcattgaaa ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca     8460

tataggacat gggcttacca tggaagctat gaggccccca cacaagggtc agcgtcctct     8520

ctaataaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca     8580

ggaatagcca tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg     8640

gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc     8700

tggttgtgga aagagctagg caaacacaaa cggccacgag tctgtaccaa agaagagttc     8760

atcaacaagg ttcgtagcaa tgcagcatta ggggcaatat ttgaagagga aaaagagtgg     8820

aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga     8880

gagcaccacc tgagaggaga gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggcta     9000

ggggctagat ttctagagtt cgaagccctt ggattcttga acgaggatca ctggatgggg     9060

agagagaact caggaggtgg tgttgaaggg ctgggattac aaagactcgg atatgtccta     9120

gaagagatga gtcgtatacc aggaggaagg atgtatgcag atgacactgc tggctgggac     9180

acccgcatta gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa     9240

gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag     9300

gtccttagac cagctgaaaa agggaaaaca gttatggaca ttatttcgag acaagaccaa     9360

agggggagcg gacaagttgt cacttacgct cttaacacat ttaccaacct agtggtgcaa     9420

ctcattcgga atatggaggc tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg     9480

aggtcagaga aagtgaccaa ctggttgcag agcaacggat gggataggct caaacgaatg     9540

gcagtcagtg gagatgattg cgttgtgaag ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa accctcaact     9660

ggatgggaca actgggaaga agttccgttt tgctcccacc atttcaacaa gctccatctc     9720

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgggcc     9780

cgcgtctctc caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     9840

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc     9900

atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt    10020

gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat    10080

ttgggaaaaa gggaagactt gtggtgtgga tctctcatag ggcacagacc gcgcaccacc    10140

tgggctgaga acattaaaaa cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagtt cgctacttgg gtgaagaagg gtctacacct    10260

ggagtgctgt aa                                                        10272


<210>  68
<211>  10617
<212>  DNA
<213>  Zika virus strain MRS_OPY_Martinique_PaRi_2015 polyprotein gene, complete cds

<400>  68
agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa       60

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      120

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      180

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      240

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaataata aagaagttca      300

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      360

gcgcagaaac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      420

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      480

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      540

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      600

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      660

acaaaaaagg tgaagcacgg agatctagaa gagccgtgac gctcccctcc cattccacta      720

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      780

ttagagtcga aaattggata ttcaggaacc ctggtttcgc tttagcagca gctgccatcg      840

cgtggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      900

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta      960

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1020

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1080

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1140

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1200

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1260

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1320

tggagtaccg gataatgttg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1380

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1440

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1500

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1560

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1620

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1680

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1740

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1800

tggataaact tagattgaag ggcgtgtcat actccttgtg taccgcagcg ttcacattca     1860

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1920

cagatggacc ttgcaaggtt ccagcccaga tggcggtgga catgcaaact ctgaccccag     1980

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2040

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2100

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2160

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2220

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2280

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2340

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2400

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2460

aggagacgag atgtggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2520

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2580

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2640

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2700

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2760

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2820

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2880

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     2940

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3000

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3060

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaaa tcccacacat     3120

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3180

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3240

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3300

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3360

ggtgctgcag ggagtgcaca atgcccccac tgtcgttctg ggctaaagat ggctgttggt     3420

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3480

ctgcaggatc aactgatcac atggatcact tctcccttgg agtgcttgtg attctgctca     3540

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3600

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3660

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3720

tgacagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3780

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3840

ctgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3900

tacgagcgat ggttgttcca cgcactgaca acatcacctt ggcaatcctg gctgctctga     3960

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4020

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4080

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4140

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4200

tgatatgtgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4260

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4320

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4380

ggctcgacgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4440

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4500

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4560

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4620

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4680

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4740

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4800

ggaagctaga tgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4860

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4920

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     4980

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaatggg agttatgtta     5040

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5100

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5160

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5220

ctccaaccag ggttgtcgct gctgaaatgg aggaagccct tagagggctt ccagtgcgtt     5280

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5340

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5400

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5460

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5520

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5580

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5640

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5700

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5760

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5820

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5880

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     5940

atcccaataa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6000

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6060

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6120

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6180

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6240

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6300

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6360

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6420

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6480

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6540

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6600

tgggaatctt tttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6660

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6720

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6780

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6840

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6900

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     6960

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7020

atgcagtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctggag     7080

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccactgc     7140

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7200

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7260

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7320

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7380

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7440

gggccctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7500

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7560

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7620

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7680

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7740

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7800

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7860

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7920

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     7980

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8040

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8100

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8160

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8220

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8280

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8340

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8400

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8460

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8520

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8580

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8640

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8700

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8760

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8820

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8880

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     8940

gaggagagtg ccagagttgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9000

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9060

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9120

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9180

gcataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcatcagca     9240

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9300

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9360

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9420

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9480

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9540

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9600

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9660

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9720

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9780

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9840

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9900

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg     9960

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10020

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10080

acatggaaga caagacccca gttgcgaaat ggacagacat tccctatttg ggaaaaaggg    10140

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10200

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10260

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10320

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10380

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10440

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10500

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10560

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggag       10617


<210>  69
<211>  10617
<212>  DNA
<213>  Zika virus strain H/PF/2013 polyprotein gene, complete cds

<400>  69
agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa       60

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      120

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      180

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      240

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaataata aagaagttca      300

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      360

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      420

tcactagacg tgggagtgca tactatatgt acttggacag aaacgacgct ggggaggcca      480

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      540

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      600

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      660

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      720

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      780

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      840

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      900

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta      960

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1020

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1080

aggtaagatc ctactgctat gaggcatcaa tatcggacat ggcttcggac agccgctgcc     1140

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1200

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1260

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1320

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1380

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1440

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1500

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1560

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1620

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1680

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1740

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1800

tggataaact tagattgaag ggcgtgtcat actccttgtg taccgcagcg ttcacattca     1860

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1920

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     1980

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2040

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2100

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2160

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2220

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2280

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2340

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2400

tgatcttctt atccacagct gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2460

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2520

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2580

aagatggtat ctgtgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2640

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2700

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2760

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2820

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2880

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     2940

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3000

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3060

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3120

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3180

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3240

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3300

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3360

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3420

atggaatgga gataaggccc aggaaagaac cagaaagtaa cttagtaagg tcaatggtga     3480

ctgcaggatc aactgatcac atggatcact tctcccttgg agtgcttgtg attctgctca     3540

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcgatgg     3600

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3660

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3720

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3780

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3840

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3900

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     3960

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4020

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4080

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4140

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4200

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4260

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4320

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4380

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4440

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4500

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4560

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4620

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4680

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4740

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4800

ggaagctaga tgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4860

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4920

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     4980

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaatggg agttatgtta     5040

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5100

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5160

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5220

ctccaaccag ggttgtcgct gctgaaatgg aggaagccct tagagggctt ccagtgcgtt     5280

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5340

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5400

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5460

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5520

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5580

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5640

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5700

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5760

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5820

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5880

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     5940

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6000

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6060

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6120

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6180

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6240

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6300

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6360

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6420

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6480

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6540

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6600

tgggaatctt tttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6660

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6720

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6780

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6840

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6900

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     6960

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7020

atgcagtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctggag     7080

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7140

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7200

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7260

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7320

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7380

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7440

gggccctgat cacagcggca acttccactt tgtgggaagg ctctccgaac aagtactgga     7500

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7560

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7620

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7680

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7740

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7800

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7860

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7920

aaggaggccc tggtcatgaa gaacccatgt tggtgcaaag ctatgggtgg aacatagtcc     7980

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8040

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8100

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8160

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8220

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8280

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8340

acgggcccag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8400

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8460

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8520

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8580

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8640

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8700

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8760

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8820

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8880

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     8940

gaggagagtg ccagagttgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9000

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9060

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9120

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9180

gcataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcatcagca     9240

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9300

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9360

ctgaaaaagg gaagacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9420

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9480

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9540

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9600

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9660

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9720

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9780

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9840

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9900

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg     9960

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10020

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10080

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10140

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10200

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10260

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10320

caccaatctt agtgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10380

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10440

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10500

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10560

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggag       10617


<210>  70
<211>  10766
<212>  DNA
<213>  Zika virus strain MR 766 polyprotein gene, complete cds

<400>  70
gatctgtgtg agtcagactg cgacagttcg agtctgaagc gagagctaac aacagtatca       60

acaggtttaa tttggatttg gaaacgagag tttctggtca tgaaaaaccc aaagaagaaa      120

tccggaggat tccggattgt caatatgcta aaacgcggag tagcccgtgt aaaccccttg      180

ggaggtttga agaggttgcc agccggactt ctgctgggtc atggacccat cagaatggtt      240

ttggcgatac tagccttttt gagatttaca gcaatcaagc catcactggg ccttatcaac      300

agatggggtt ccgtggggaa aaaagaggct atggaaataa taaagaagtt caagaaagat      360

cttgctgcca tgttgagaat aatcaatgct aggaaagaga ggaagagacg tggcgcagac      420

accagcatcg gaatcattgg cctcctgctg actacagcca tggcagcaga gatcactaga      480

cgcgggagtg catactacat gtacttggat aggagcgatg ccgggaaggc catttcgttt      540

gctaccacat tgggagtgaa caagtgccac gtacagatca tggacctcgg gcacatgtgt      600

gacgccacca tgagttatga gtgccctatg ctggatgagg gagtggaacc agatgatgtc      660

gattgctggt gcaacacgac atcaacttgg gttgtgtacg gaacctgtca tcacaaaaaa      720

ggtgaggcac ggcgatctag aagagccgtg acgctccctt ctcactctac aaggaagttg      780

caaacgcggt cgcagacctg gttagaatca agagaataca cgaagcactt gatcaaggtt      840

gaaaactgga tattcaggaa ccccgggttt gcgctagtgg ccgttgccat tgcctggctt      900

ttgggaagct cgacgagcca aaaagtcata tacttggtca tgatactgct gattgccccg      960

gcatacagta tcaggtgcat tggagtcagc aatagagact tcgtggaggg catgtcaggt     1020

gggacctggg ttgatgttgt cttggaacat ggaggctgcg ttaccgtgat ggcacaggac     1080

aagccaacag ttgacataga gttggtcacg acgacggtta gtaacatggc cgaggtaaga     1140

tcctattgct acgaggcatc gatatcggac atggcttcgg acagtcgttg cccaacacaa     1200

ggtgaagcct accttgacaa gcaatcagac actcaatatg tctgcaaaag aacattagtg     1260

gacagaggtt ggggaaacgg ttgtggactt tttggcaaag ggagcttggt gacatgtgcc     1320

aagtttacgt gttctaagaa gatgaccggg aagagcattc aaccggaaaa tctggagtat     1380

cggataatgc tatcagtgca tggctcccag catagcggga tgattgtcaa tgatacagga     1440

tatgaaactg acgaaaatag agcgaaagtc gaggttacgc ctaattcacc aagagcggaa     1500

gcaaccttgg gaggctttgg aagcttagga cttgactgtg aaccaaggac aggccttgac     1560

ttttcagatc tgtattacct gaccatgaac aataagcatt ggttggtgca caaagagtgg     1620

tttcatgaca tcccattgcc ttggcatgct ggggcagaca ccggaactcc acactggaac     1680

aacaaagagg cattggtaga attcaaggat gcccacgcca agaggcaaac cgtcgtcgtt     1740

ctggggagcc aggaaggagc cgttcacacg gctctcgctg gagctctaga ggctgagatg     1800

gatggtgcaa agggaaagct gttctctggc catttgaaat gccgcctaaa aatggacaag     1860

cttagattga agggcgtgtc atattccttg tgcactgcgg cattcacatt caccaaggtc     1920

ccagctgaaa cactgcatgg aacagtcaca gtggaggtgc agtatgcagg gacagatgga     1980

ccctgcaaga tcccagtcca gatggcggtg gacatgcaga ccctgacccc agttggaagg     2040

ctgataaccg ccaaccccgt gattactgaa agcactgaga actcaaagat gatgttggag     2100

cttgacccac catttgggga ttcttacatt gtcataggag ttggggacaa gaaaatcacc     2160

caccactggc ataggagtgg tagcaccatc ggaaaggcat ttgaggccac tgtgagaggc     2220

gccaagagaa tggcagtcct gggggataca gcctgggact tcggatcagt cgggggtgtg     2280

ttcaactcac tgggtaaggg cattcaccag atttttggag cagccttcaa atcactgttt     2340

ggaggaatgt cctggttctc acagatcctc ataggcacgc tgctagtgtg gttaggtttg     2400

aacacaaaga atggatctat ctccctcaca tgcttggccc tggggggagt gatgatcttc     2460

ctctccacgg ctgtttctgc tgacgtgggg tgctcagtgg acttctcaaa aaaggaaacg     2520

agatgtggca cgggggtatt catctataat gatgttgaag cctggaggga ccggtacaag     2580

taccatcctg actccccccg cagattggca gcagcagtca agcaggcctg ggaagagggg     2640

atctgtggga tctcatccgt ttcaagaatg gaaaacatca tgtggaaatc agtagaaggg     2700

gagctcaatg ctatcctaga ggagaatgga gttcaactga cagttgttgt gggatctgta     2760

aaaaacccca tgtggagagg tccacaaaga ttgccagtgc ctgtgaatga gctgccccat     2820

ggctggaaag cctgggggaa atcgtatttt gttagggcgg caaagaccaa caacagtttt     2880

gttgtcgacg gtgacacact gaaggaatgt ccgcttgagc acagagcatg gaatagtttt     2940

cttgtggagg atcacgggtt tggagtcttc cacaccagtg tctggcttaa ggtcagagaa     3000

gattactcat tagaatgtga cccagccgtc ataggaacag ctgttaaggg aagggaggcc     3060

gcgcacagtg atctgggcta ttggattgaa agtgaaaaga atgacacatg gaggctgaag     3120

agggcccacc tgattgagat gaaaacatgt gaatggccaa agtctcacac attgtggaca     3180

gatggagtag aagaaagtga tcttatcata cccaagtctt tagctggtcc actcagccac     3240

cacaacacca gagagggtta cagaacccaa gtgaaagggc catggcacag tgaagagctt     3300

gaaatccggt ttgaggaatg tccaggcacc aaggtttacg tggaggagac atgcggaact     3360

agaggaccat ctctgagatc aactactgca agtggaaggg tcattgagga atggtgctgt     3420

agggaatgca caatgccccc actatcgttt cgagcaaaag acggctgctg gtatggaatg     3480

gagataaggc ccaggaaaga accagagagc aacttagtga ggtcaatggt gacagcgggg     3540

tcaaccgatc atatggacca cttctctctt ggagtgcttg tgattctact catggtgcag     3600

gaggggttga agaagagaat gaccacaaag atcatcatga gcacatcaat ggcagtgctg     3660

gtagtcatga tcttgggagg attttcaatg agtgacctgg ccaagcttgt gatcctgatg     3720

ggtgctactt tcgcagaaat gaacactgga ggagatgtag ctcacttggc attggtagcg     3780

gcatttaaag tcagaccagc cttgctggtc tccttcattt tcagagccaa ttggacaccc     3840

cgtgagagca tgctgctagc cctggcttcg tgtcttctgc aaactgcgat ctctgctctt     3900

gaaggtgact tgatggtcct cattaatgga tttgctttgg cctggttggc aattcgagca     3960

atggccgtgc cacgcactga caacatcgct ctaccaatct tggctgctct aacaccacta     4020

gctcgaggca cactgctcgt ggcatggaga gcgggcctgg ctacttgtgg agggatcatg     4080

ctcctctccc tgaaagggaa aggtagtgtg aagaagaacc tgccatttgt catggccctg     4140

ggattgacag ctgtgagggt agtagaccct attaatgtgg taggactact gttactcaca     4200

aggagtggga agcggagctg gccccctagt gaagttctca cagccgttgg cctgatatgt     4260

gcactggccg gagggtttgc caaggcagac attgagatgg ctggacccat ggctgcagta     4320

ggcttgctaa ttgtcagcta tgtggtctcg ggaaagagtg tggacatgta cattgaaaga     4380

gcaggtgaca tcacatggga aaaggacgcg gaagtcactg gaaacagtcc tcggcttgac     4440

gtggcactgg atgagagtgg tgatttctcc ttggtagagg aagatggtcc acccatgaga     4500

gagatcatac tcaaggtggt cctgatggcc atctgtggca tgaacccaat agctatacct     4560

tttgctgcag gagcgtggta tgtgtatgtg aagactggga aaaggagtgg cgccctctgg     4620

gacgtgcctg ctcccaaaga agtgaagaaa ggagagacca cagatggagt gtacagagtg     4680

atgactcgca gactgctagg ttcaacacag gttggagtgg gagtcatgca agagggagtc     4740

ttccacacca tgtggcacgt tacaaaagga gccgcactga ggagcggtga gggaagactt     4800

gatccatact ggggggatgt caagcaggac ttggtgtcat actgtgggcc ttggaagttg     4860

gatgcagctt gggatggact cagcgaggta cagcttttgg ccgtacctcc cggagagagg     4920

gccagaaaca ttcagaccct gcctggaata ttcaagacaa aggacgggga catcggagca     4980

gttgctctgg actaccctgc agggacctca ggatctccga tcctagacaa atgtggaaga     5040

gtgataggac tctatggcaa tggggttgtg atcaagaatg gaagctatgt tagtgctata     5100

acccagggaa agagggagga ggagactccg gttgaatgtt tcgaaccctc gatgctgaag     5160

aagaagcagc taactgtctt ggatctgcat ccaggagccg gaaaaaccag gagagttctt     5220

cctgaaatag tccgtgaagc cataaaaaag agactccgga cagtgatctt ggcaccaact     5280

agggttgtcg ctgctgagat ggaggaggcc ttgagaggac ttccggtgcg ttacatgaca     5340

acagcagtca acgtcaccca ttctgggaca gaaatcgttg atttgatgtg ccatgccact     5400

ttcacttcac gcttactaca acccatcaga gtccctaatt acaatctcta catcatggat     5460

gaagcccact tcacagaccc ctcaagtata gctgcaagag gatacatatc aacaagggtt     5520

gaaatgggcg aggcggctgc catttttatg actgccacac caccaggaac ccgtgatgcg     5580

tttcctgact ctaactcacc aatcatggac acagaagtgg aagtcccaga gagagcctgg     5640

agctcaggct ttgattgggt gacagaccat tctgggaaaa cagtttggtt cgttccaagc     5700

gtgagaaacg gaaatgaaat cgcagcctgt ctgacaaagg ctggaaagcg ggtcatacag     5760

ctcagcagga agacttttga gacagaattt cagaaaacaa aaaatcaaga gtgggacttt     5820

gtcataacaa ctgacatctc agagatgggc gccaacttca aggctgaccg ggtcatagac     5880

tctaggagat gcctaaaacc agtcatactt gatggtgaga gagtcatctt ggctgggccc     5940

atgcctgtca cgcatgctag tgctgctcag aggagaggac gtataggcag gaaccctaac     6000

aaacctggag atgagtacat gtatggaggt gggtgtgcag agactgatga aggccatgca     6060

cactggcttg aagcaagaat gcttcttgac aacatctacc tccaggatgg cctcatagcc     6120

tcgctctatc ggcctgaggc cgataaggta gccgccattg agggagagtt taagctgagg     6180

acagagcaaa ggaagacctt cgtggaactc atgaagagag gagaccttcc cgtctggcta     6240

gcctatcagg ttgcatctgc cggaataact tacacagaca gaagatggtg ctttgatggc     6300

acaaccaaca acaccataat ggaagacagc gtaccagcag aggtgtggac aaagtatgga     6360

gagaagagag tgctcaaacc gagatggatg gatgctaggg tctgttcaga ccatgcggcc     6420

ctgaagtcgt tcaaagaatt cgccgctgga aaaagaggag cggctttggg agtaatggag     6480

gccctgggaa cactgccagg acacatgaca gagaggtttc aggaagccat tgacaacctc     6540

gccgtgctca tgcgagcaga gactggaagc aggccttata aggcagcggc agcccaactg     6600

ccggagaccc tagagaccat tatgctctta ggtttgctgg gaacagtttc actggggatc     6660

ttcttcgtct tgatgcggaa taagggcatc gggaagatgg gctttggaat ggtaaccctt     6720

ggggccagtg catggctcat gtggctttcg gaaattgaac cagccagaat tgcatgtgtc     6780

ctcattgttg tgtttttatt actggtggtg ctcatacccg agccagagaa gcaaagatct     6840

ccccaagata accagatggc aattatcatc atggtggcag tgggccttct aggtttgata     6900

actgcaaacg aacttggatg gctggaaaga acaaaaaatg acatagctca tctaatggga     6960

aggagagaag aaggagcaac catgggattc tcaatggaca ttgatctgcg gccagcctcc     7020

gcctgggcta tctatgccgc attgacaact ctcatcaccc cagctgtcca acatgcggta     7080

accacttcat acaacaacta ctccttaatg gcgatggcca cacaagctgg agtgctgttt     7140

ggcatgggca aagggatgcc attttatgca tgggaccttg gagtcccgct gctaatgatg     7200

ggttgctatt cacaattaac acccctgact ctgatagtag ctatcattct gcttgtggcg     7260

cactacatgt acttgatccc aggcctacaa gcggcagcag cgcgtgctgc ccagaaaagg     7320

acagcagctg gcatcatgaa gaatcccgtt gtggatggaa tagtggtaac tgacattgac     7380

acaatgacaa tagaccccca ggtggagaag aagatgggac aagtgttact catagcagta     7440

gccatctcca gtgctgtgct gctgcggacc gcctggggat ggggggaggc tggagctctg     7500

atcacagcag cgacctccac cttgtgggaa ggctctccaa acaaatactg gaactcctct     7560

acagccacct cactgtgcaa catcttcaga ggaagctatc tggcaggagc ttcccttatc     7620

tatacagtga cgagaaacgc tggcctggtt aagagacgtg gaggtgggac gggagagact     7680

ctgggagaga agtggaaagc tcgtctgaat cagatgtcgg ccctggagtt ctactcttat     7740

aaaaagtcag gtatcactga agtgtgtaga gaggaggctc gccgtgccct caaggatgga     7800

gtggccacag gaggacatgc cgtatcccgg ggaagtgcaa agctcagatg gttggtggag     7860

agaggatatc tgcagcccta tgggaaggtt gttgacctcg gatgtggcag agggggctgg     7920

agctattatg ccgccaccat ccgcaaagtg caggaggtga gaggatacac aaagggaggt     7980

cccggtcatg aagaacccat gctggtgcaa agctatgggt ggaacatagt tcgtctcaag     8040

agtggagtgg acgtcttcca catggcggct gagccgtgtg acactctgct gtgtgacata     8100

ggtgagtcat catctagtcc tgaagtggaa gagacacgaa cactcagagt gctctctatg     8160

gtgggggact ggcttgaaaa aagaccaggg gccttctgta taaaggtgct gtgcccatac     8220

accagcacta tgatggaaac catggagcga ctgcaacgta ggcatggggg aggattagtc     8280

agagtgccat tgtctcgcaa ctccacacat gagatgtact gggtctctgg ggcaaagagc     8340

aacatcataa aaagtgtgtc caccacaagt cagctcctcc tgggacgcat ggatggcccc     8400

aggaggccag tgaaatatga ggaggatgtg aacctcggct cgggtacacg agctgtggca     8460

agctgtgctg aggctcctaa catgaaaatc atcggcaggc gcattgagag aatccgcaat     8520

gaacatgcag aaacatggtt tcttgatgaa aaccacccat acaggacatg ggcctaccat     8580

gggagctacg aagcccccac gcaaggatca gcgtcttccc tcgtgaacgg ggttgttaga     8640

ctcctgtcaa agccttggga cgtggtgact ggagttacag gaatagccat gactgacacc     8700

acaccatacg gccaacaaag agtcttcaaa gaaaaagtgg acaccagggt gccagatccc     8760

caagaaggca ctcgccaggt aatgaacata gtctcttcct ggctgtggaa ggagctgggg     8820

aaacgcaagc ggccacgcgt ctgcaccaaa gaagagttta tcaacaaggt gcgcagcaat     8880

gcagcactgg gagcaatatt tgaagaggaa aaagaatgga agacggctgt ggaagctgtg     8940

aatgatccaa ggttttgggc cctagtggat agggagagag aacaccacct gagaggagag     9000

tgtcacagct gtgtgtacaa catgatggga aaaagagaaa agaagcaagg agagttcggg     9060

aaagcaaaag gtagccgcgc catctggtac atgtggttgg gagccagatt cttggagttt     9120

gaagcccttg gattcttgaa cgaggaccat tggatgggaa gagaaaactc aggaggtgga     9180

gtcgaagggt taggattgca aagacttgga tacattctag aagaaatgaa tcgggcacca     9240

ggaggaaaga tgtacgcaga tgacactgct ggctgggaca cccgcattag taagtttgat     9300

ctggagaatg aagctctgat taccaaccaa atggaggaag ggcacagaac tctggcgttg     9360

gccgtgatta aatacacata ccaaaacaaa gtggtgaagg ttctcagacc agctgaagga     9420

ggaaaaacag ttatggacat catttcaaga caagaccaga gagggagtgg acaagttgtc     9480

acttatgctc tcaacacatt caccaacttg gtggtgcagc ttatccggaa catggaagct     9540

gaggaagtgt tagagatgca agacttatgg ttgttgagga agccagagaa agtgaccaga     9600

tggttgcaga gcaatggatg ggatagactc aaacgaatgg cggtcagtgg agatgactgc     9660

gttgtgaagc caatcgatga taggtttgca catgccctca ggttcttgaa tgacatggga     9720

aaagttagga aagacacaca ggagtggaaa ccctcgactg gatggagcaa ttgggaagaa     9780

gtcccgttct gctcccacca cttcaacaag ctgtacctca aggatgggag atccattgtg     9840

gtcccttgcc gccaccaaga tgaactgatt ggccgagctc gcgtctcacc aggggcagga     9900

tggagcatcc gggagactgc ctgtcttgca aaatcatatg cgcagatgtg gcagctcctt     9960

tatttccaca gaagagacct tcgactgatg gctaatgcca tttgctcggc tgtgccagtt    10020

gactgggtac caactgggag aaccacctgg tcaatccatg gaaagggaga atggatgacc    10080

actgaggaca tgctcatggt gtggaataga gtgtggattg aggagaacga ccatatggag    10140

gacaagactc ctgtaacaaa atggacagac attccctatc taggaaaaag ggaggactta    10200

tggtgtggat cccttatagg gcacagaccc cgcaccactt gggctgaaaa catcaaagac    10260

acagtcaaca tggtgcgcag gatcataggt gatgaagaaa agtacatgga ctatctatcc    10320

acccaagtcc gctacttggg tgaggaaggg tccacacccg gagtgttgta agcaccaatt    10380

ttagtgttgt caggcctgct agtcagccac agtttgggga aagctgtgca gcctgtaacc    10440

cccccaggag aagctgggaa accaagctca tagtcaggcc gagaacgcca tggcacggaa    10500

gaagccatgc tgcctgtgag cccctcagag gacactgagt caaaaaaccc cacgcgcttg    10560

gaagcgcagg atgggaaaag aaggtggcga ccttccccac ccttcaatct ggggcctgaa    10620

ctggagacta gctgtgaatc tccagcagag ggactagtgg ttagaggaga ccccccggaa    10680

aacgcacaac agcatattga cgctgggaaa gaccagagac tccatgagtt tccaccacgc    10740

tggccgccag gcacagatcg ccgaac                                         10766


<210>  71
<211>  10272
<212>  DNA
<213>  Zika virus strain 8375 polyprotein gene, complete cds

<400>  71
atgaaaaacc caaaaaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt      120

catgggccca tcaggatggt cttggcgatt ctagcctttt tgagattcac ggcaatcaag      180

ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag      300

aagaagagac gaggcgcaga tactagtgtc ggaattgttg gcctcctgct gaccacagct      360

atggcagcgg aggtcactag acgtgggagt gcatactata tgtacttgga cagaaacgat      420

gctggggagg ccatatcttt tccaaccaca ttggggatga ataagtgtta tatacagatc      480

atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gctggatgag      540

ggggtggaac cagatgacgt cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac      600

ggaacctgcc atcacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctcccc      660

tcccattcca ctaggaagct gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac      720

acaaagcact tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca      780

gcagctgcca tcgcttggct tttgggaagc tcaacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac      900

tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt      960

gtcaccgtaa tggcacagga caaaccgact gtcgacatag agctggttac aacaacagtc     1020

agcaacatgg cggagataag atcctactgc tatgaggcat caatatcaga catggcttcg     1080

gacagccgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa     1200

gggagcctgg tgacatgcgc taagtttgca tgctccaaga aaatgaccgg gaagagcatc     1260

cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg     1320

atgatcgtta atgacacagg acatgaaact gatgagaata gagcgaaggt tgagataacg     1380

cccaattcac caagagccga agccaccctg gggggttttg gaagcctagg acttgattgt     1440

gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac     1500

tggttggttc acaaggagtg gttccacgac attccattac cttggcacgc tggggcagac     1560

accggaactc cacactggaa caacaaagaa gcactggtgg agttcaagga cgcacatgcc     1620

aaaaggcaaa ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa     1740

tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtaccgca     1800

gcgttcacat tcaccaagat cccggctgaa acactgcacg ggacagtcac agtggaggta     1860

cagtacgcag ggacagatgg accttgcaag gttccagctc agatggcggt ggacatgcaa     1920

actctgaccc cagttgggag gttgataacc gctaaccccg taatcactga aagcactgag     1980

aactctaaga tgatgctgga acttgatcca ccatttgggg actcttacat tgtcatagga     2040

gtcggggaga agaagatcac ccaccactgg cacaggagtg gcagcaccat tggaaaagca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggac     2160

tttggatcag ttggaggcgc tctcaactca ttgggcaagg gcatccatca aatttttgga     2220

gctgctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg     2280

ttgctgatgt ggttgggtct gaacacaaag aatggatcta tttcccttat gtgcttggcc     2340

ttagggggag tgttgatctt cttatccaca gccgtctctg ctgatgtggg gtgctcggtg     2400

gacttctcaa agaaggagac gagatgcggt acaggggtgt tcgtctataa cgacgttgaa     2460

gcctggaggg acaggtacaa gtaccatcct gactcccccc gtagattggc agcagcagtc     2520

aagcaagcct gggaagatgg tatctgcggg atctcctctg tttcaagaat ggaaaacatc     2580

atgtggagat cagtagaagg ggagctcaac gcaatcctgg aagagaatgg agttcaactg     2640

acggtcgttg tgggatctgt aaaaaacccc atgtggagag ctccacagag attgcccgtg     2700

cctgtgaacg agctgcccca cggctggaag gcttggggga aatcgtactt cgtcagagca     2760

gcaaagacaa ataacagctt tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa     2820

catagagcat ggaacagctt tcttgtggag gatcatgggt tcggggtatt tcacactagt     2880

gtctggctca aggttagaga agattattca ttagagtgtg atccagccgt tattggaaca     2940

gctgttaagg gaaaggaggc tgtacacagt gatctaggct actggattga gagtgagaag     3000

aatgacacat ggaggctgaa gagggcccat ctgatcgaga tgaaaacatg tgaatggcca     3060

aagtcccaca cattgtggac agatggaata gaagagagtg atctgatcat acccaagtct     3120

ttagctgggc cactcagcca tcacaatacc agagagggct acaggaccca aatgaaaggg     3180

ccatggcaca gtgaagagct tgaaattcgg tttgaggaat gcccaggcac taaggtccac     3240

gtggaggaaa catgtggaac aagaggacca tctctgagat caaccactgc aagcggaagg     3300

gtgatcgagg aatggtgctg cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa     3360

gatggctgtt ggtatggaat ggagataagg cccaggaaag aaccagaaag caacttagta     3420

aggtcaatgg tgactgcagg atcaactgat cacatggatc acttctccct tggagtgctt     3480

gtgattctgc tcatggtgca ggaagggcta aagaagagaa tgaccacaaa gatcatcata     3540

agcacatcaa tggcagtgct ggtagctatg atcctgggag gattttcaat gagtgacctg     3600

gctaagcttg caattttgat gggtgccacc ttcgcggaaa tgaacactgg aggagatgta     3660

gctcatctgg cgctgatagc ggcattcaaa gtcagaccag cgttgctggt atctttcatc     3720

ttcagagcta attggacacc ccgtgaaagc atgctactgg ccttggcctc gtgtcttttg     3780

caaactgcga tctccgcctt ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg     3840

gcctggttgg caatacgagc gatggttgtt ccacgcactg ataacatcac cttggcaatc     3900

ctggctgctc tgacaccact ggcccggggc acactgcttg tggcgtggag agcaggcctt     3960

gctacttgcg gggggtttat gctcctctct ctgaagggaa aaggcagtgt gaagaagaac     4020

ttaccatttg tcatggccct gggactaacc gctgtgaggc tggtcgaccc catcaacgtg     4080

gtgggactgc tgttgctcac aaggagtggg aagcggagct ggccccctag cgaagtactc     4140

acagctgttg gcctgatatg cgcattggct ggagggttcg ccaaggcaga tatagagatg     4200

gctgggccca tggccgcggt cggtctgcta attgtcagtt acgtggtctc aggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaagatgc ggaagtcact     4320

ggaaacagtc cccggctcga tgtggcgcta gatgagagtg gtgatttctc cctggtggag     4380

gatgacggtc cccccatgag agagatcata ctcaaggtgg tcctgatgac catctgtggc     4440

atgaacccaa tagccatacc ctttgcagct ggagcgtggt acgtatacgt gaagactgga     4500

aaaaggagtg gtgctctatg ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc     4560

acagatggag tgtacagagt aatgactcgt agactgctag gttcaacaca agttggagtg     4620

ggagttatgc aagagggggt ctttcacact atgtggcacg tcacaaaagg atccgcactg     4680

agaagcggtg aagggagact tgatccatac tggggagatg tcaagcagga tctggtgtca     4740

tactgtggtc catggaagct agatgccgcc tgggacgggc acagcgaggt gcagctcttg     4800

gccgtgcccc ccggagagag agcgaggaac atccagactc tgcccggaat atttaagaca     4860

aaggatgggg acattggagc ggttgcgctg gattacccag caggaacttc aggatctcca     4920

atcctagaca agtgtgggag agtgatagga ctttatggca atggggtcgt gatcaaaaat     4980

gggagttatg ttagtgccat cacccaaggg aggagggagg aagagactcc tgttgagtgc     5040

ttcgagcctt cgatgctgaa gaagaagcag ctaactgtct tagacttaca tcctggagct     5100

gggaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaac aagactccgt     5160

actgtgatct tagctccaac cagggttgtc gctgctgaaa tggaggaggc ccttagaggg     5220

cttccagtgc gttatatgac aacagcagtc aatgtcaccc actctggaac agaaatcgtc     5280

gacttaatgt gccatgccac cttcacttca cgtctactac agccaatcag agtccccaac     5340

tataatctgt atattatgga tgaggcccac ttcacagatc cctcaagtat agcagcaaga     5400

ggatacattt caacaagggt tgagatgggc gaggcggctg ccatcttcat gaccgccacg     5460

ccaccaggaa cccgtgacgc atttccggac tccaactcac caattatgga caccgaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacggatca ttctggaaaa     5580

acagtttggt ttgttccaag cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag     5640

gctggaaaac gggtcataca gctcagcaga aagacttttg agacagagtt ccagaaaaca     5700

aaacatcaag agtgggactt tgtcgtgaca actgacattt cagagatggg cgccaacttt     5760

aaagctgacc gtgtcataga ttccaggaga tgcctaaagc cggtcatact tgatggcgag     5820

agagtcattc tggctggacc catgcctgtc acacatgcca gcgctgccca gaggaggggg     5880

cgcataggca ggaatcccaa caaacctgga gatgagtatc tgtatggagg tgggtgcgca     5940

gagactgacg aagaccatgc acactggctt gaagcaagaa tgctccttga caatatttac     6000

ctccaagatg gcctcatagc ctcgctctat cgacctgagg ccgacaaagt agcagccatt     6060

gagggagagt tcaagcttag gacggagcaa aggaagacct ttgtggaact catgaaaaga     6120

ggagatcttc ctgtttggct ggcctatcag gttgcatctg ccggaataac ctacacagat     6180

agaagatggt gctttgatgg cacgaccaac aacaccatac tggaagacag tgtgccggca     6240

gaggtgtgga ccagacacgg agagaaaaga gtgctcaaac cgaggtggat ggacgccaga     6300

gtttgttcag atcatgcggc cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga     6360

gcggcttttg gagtgatgga agccttggga acactgccag gacacatgac agagagattc     6420

caggaagcca ttgacaacct cgctgtgctc atgcgggcag agactggaag caggccttac     6480

aaagccgcgg cggcccaatt gccggagacc ctagagacca ttatgctttt ggggttgctg     6540

ggaacagtct cgctgggaat ctttttcgtc ttgatgagga acaagggcat agggaagatg     6600

ggctttggaa tggtgaccct tggggccagt gcatggctca tgtggctctc ggaaattgag     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgttcctat tgctggtggt gctcatacct     6720

gagccagaaa agcaaagatc tccccaggac aaccaaatgg caatcatcat catggtagca     6780

gtaggtcttc tgggcttgat taccgccaat gaactcggat ggttggagag aacaaagagt     6840

gacctaagcc atctaatggg aaggagagag gagggagcaa ccataggatt ctcaatggac     6900

attgacctgc ggccagcctc agcttgggcc atctatgctg ccttgacaac tttcattacc     6960

ccagccgtcc aacatgcagt gaccacttca tacaacaact actccttaat ggcgatggcc     7020

acgcaagctg gagtgttgtt tggtatgggc aaagggatgc cattctacgc atgggacttt     7080

ggagtcccgc tgctaatgat aggttgctac tcacaattaa cacccctgac cctaatagtg     7140

gccatcattt tgctcgtggc gcactacatg tacttgatcc cagggctgca ggcagcagct     7200

gcgcgtgctg cccagaagag aacggcagct ggcatcatga agaaccctgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa aaagatggga     7320

caggtgctac tcatagcagt agccgtctcc agcgccatac tgtcgcggac cgcctggggg     7380

tggggggagg ctggggccct gatcacagcc gcaacttcca ctttgtggga aggctctccg     7440

aacaagtact ggaactcctc tacagccact tcactgtgta acatttttag gggaagttac     7500

ttggctggag cttctctaat ctacacagta acaagaaacg ctggcttggt caagagacgt     7560

gggggtggaa caggagagac cctgggagag aaatggaagg cccgcttgaa ccagatgtcg     7620

gccctggagt tctactccta caaaaagtca ggcatcactg aggtgtgcag agaagaggcc     7680

cgccgcgccc tcaaggacgg tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca     7740

aagctgagat ggttggtgga gcggggatac ctgcagccct atggaaaggt cattgatctt     7800

ggatgtggca gagggggctg gagttactac gccgccacca tccgcaaagt tcaagaagtg     7860

aaaggataca caaaaggagg ccctggtcat gaagaacccg tgttggtgca aagctatggg     7920

tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt     7980

gacacgttgc tgtgtgacat aggcgagtca tcatctagtc ctgaagtgga agaagcacgg     8040

acgctcagag tcctctccat ggtgggggat tggcttgaaa gaagaccagg agccttttgt     8100

ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt     8160

aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac     8220

tgggtctctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctc     8280

ttggggcgca tggacgggcc taggaggcca gtgaaatatg aggaggatgt gaatctcggc     8340

tctggcacgc gggctgtggt aagctgcgct gaagctccca acatgaagat cattggtaac     8400

cgcattgaaa ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca     8460

tataggacat gggcttacca tggaagctat gaggccccca cacaagggtc agcgtcctct     8520

ctaataaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca     8580

ggaatagcca tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg     8640

gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc     8700

tggttgtgga aagagctagg caaacacaaa cggccacgag tctgtaccaa agaagagttc     8760

atcaacaagg ttcgtagcaa tgcagcatta ggggcaatat ttgaagagga aaaagagtgg     8820

aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga     8880

gagcaccacc tgagaggaga gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggcta     9000

ggggctagat ttctagagtt cgaagccctt ggattcttga acgaggatca ctggatgggg     9060

agagagaact caggaggtgg tgttgaaggg ctgggattac aaagactcgg atatgtccta     9120

gaagagatga gttgcatacc aggaggaagg atgtatgcag atgacactgc tggctgggac     9180

acccgcatca gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa     9240

gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag     9300

gtccttagac cagctgaaaa agggaaaaca gttatggaca ttatttcaag acaagaccaa     9360

agggggagcg gacaagttgt cacttacgct cttaacacat ttaccaacct agtggtgcaa     9420

ctcattcgga atatggaggc tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg     9480

aggtcagaga aagtgaccaa ctggttgcag agcaacggat gggataggct caaacgaatg     9540

gcagtcagtg gagatgattg cgttgtgaag ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa accctcaact     9660

ggatgggaca actgggaaga agttccgttt tgctcccacc acttcaacaa gctccatctc     9720

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgggcc     9780

cgcgtctctc caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     9840

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc     9900

atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt    10020

gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat    10080

ttgggaaaaa gggaagactt gtggtgtgga tctctcatag ggcacagacc gcgcaccacc    10140

tgggctgaga acattaaaaa cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagtt cgctacttgg gtgaagaagg gtctacacct    10260

ggagtgctgt aa                                                        10272


<210>  72
<211>  10272
<212>  DNA
<213>  Zika virus strain 103344 polyprotein gene, complete cds

<400>  72
atgaaaaacc caaaaaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt      120

catgggccca tcaggatggt cttggcgatt ctagcctttt tgagattcac ggcaatcaag      180

ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag      300

aagaagagac gaggcgcaga tactagtgtc ggaattgttg gcctcctgct gaccacagct      360

atggcagcgg aggtcactag acgtgggagt gcatactata tgtacttgga cagaaacgat      420

gctggggagg ccatatcttt tccaaccaca ttggggatga ataagtgtta tatacagatc      480

atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gctggatgag      540

ggggtggaac cagatgacgt cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac      600

ggaacctgcc atcacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctcccc      660

tcccattcca ctaggaagct gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac      720

acaaagcact tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca      780

gcagctgcca tcgcttggct tttgggaagc tcaacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac      900

tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt      960

gtcaccgtaa tggcacagga caaaccgact gtcgacatag agctggttac aacaacagtc     1020

agcaacatgg cggagataag atcctactgc tatgaggcat caatatcaga catggcttcg     1080

gacagccgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa     1200

gggagcctgg tgacatgcgc taagtttgca tgctccaaga aaatgaccgg gaagagcatc     1260

cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg     1320

atgatcgtta atgacacagg acatgaaact gatgagaata gagcgaaggt tgagataacg     1380

cccaattcac caagagccga agccaccctg gggggttttg gaagcctagg acttgattgt     1440

gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac     1500

tggttggttc acaaggagtg gttccacgac attccattac cttggcacgc tggggcagac     1560

accggaactc cacactggaa caacaaagaa gcactggtgg agttcaagga cgcacatgcc     1620

aaaaggcaaa ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa     1740

tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtaccgca     1800

gcgttcacat tcaccaagat cccggctgaa acactgcacg ggacagtcac agtggaggta     1860

cagtacgcag ggacagatgg accttgcaag gttccagctc agatggcggt ggacatgcaa     1920

actctgaccc cagttgggag gttgataacc gctaaccccg taatcactga aagcactgag     1980

aactctaaga tgatgctgga acttgatcca ccatttgggg actcttacat tgtcatagga     2040

gtcggggaga agaagatcac ccaccactgg cacaggagtg gcagcaccat tggaaaagca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggac     2160

tttggatcag ttggaggcgc tctcaactca ttgggcaagg gcatccatca aatttttgga     2220

gctgctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg     2280

ttgctgatgt ggttgggtct gaacacaaag aatggatcta tttcccttat gtgcttggcc     2340

ttagggggag tgttgatctt cttatccaca gccgtctctg ctgatgtggg gtgctcggtg     2400

gacttctcaa agaaggagac gagatgcggt acaggggtgt tcgtctataa cgacgttgaa     2460

gcctggaggg acaggtacaa gtaccatcct gactcccccc gtagattggc agcagcagtc     2520

aagcaagcct gggaagatgg tatctgcggg atctcctctg tttcaagaat ggaaaacatc     2580

atgtggagat cagtagaagg ggagctcaac gcaatcctgg aagagaatgg agttcaactg     2640

acggtcgttg tgggatctgt aaaaaacccc atgtggagag ctccacagag attgcccgtg     2700

cctgtgaacg agctgcccca cggctggaag gcttggggga aatcgtactt cgtcagagca     2760

gcaaagacaa ataacagctt tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa     2820

catagagcat ggaacagctt tcttgtggag gatcatgggt tcggggtatt tcacactagt     2880

gtctggctca aggttagaga agattattca ttagagtgtg atccagccgt tattggaaca     2940

gctgttaagg gaaaggaggc tgtacacagt gatctaggct actggattga gagtgagaag     3000

aatgacacat ggaggctgaa gagggcccat ctgatcgaga tgaaaacatg tgaatggcca     3060

aagtcccaca cattgtggac agatggaata gaagagagtg atctgatcat acccaagtct     3120

ttagctgggc cactcagcca tcacaatacc agagagggct acaggaccca aatgaaaggg     3180

ccatggcaca gtgaagagct tgaaattcgg tttgaggaat gcccaggcac taaggtccac     3240

gtggaggaaa catgtggaac aagaggacca tctctgagat caaccactgc aagcggaagg     3300

gtgatcgagg aatggtgctg cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa     3360

gatggctgtt ggtatggaat ggagataagg cccaggaaag aaccagaaag caacttagta     3420

aggtcaatgg tgactgcagg atcaactgat cacatggatc acttctccct tggagtgctt     3480

gtgattctgc tcatggtgca ggaagggcta aagaagagaa tgaccacaaa gatcatcata     3540

agcacatcaa tggcagtgct ggtagctatg atcctgggag gattttcaat gagtgacctg     3600

gctaagcttg caattttgat gggtgccacc ttcgcggaaa tgaacactgg aggagatgta     3660

gctcatctgg cgctgatagc ggcattcaaa gtcagaccag cgttgctggt atctttcatc     3720

ttcagagcta attggacacc ccgtgaaagc atgctactgg ccttggcctc gtgtcttttg     3780

caaactgcga tctccgcctt ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg     3840

gcctggttgg caatacgagc gatggttgtt ccacgcactg ataacatcac cttggcaatc     3900

ctggctgctc tgacaccact ggcccggggc acactgcttg tggcgtggag agcaggcctt     3960

gctacttgcg gggggtttat gctcctctct ctgaagggaa aaggcagtgt gaagaagaac     4020

ttaccatttg tcatggccct gggactaacc gctgtgaggc tggtcgaccc catcaacgtg     4080

gtgggactgc tgttgctcac aaggagtggg aagcggagct ggccccctag cgaagtactc     4140

acagctgttg gcctgatatg cgcattggct ggagggttcg ccaaggcaga tatagagatg     4200

gctgggccca tggccgcggt cggtctgcta attgtcagtt acgtggtctc aggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaagatgc ggaagtcact     4320

ggaaacagtc cccggctcga tgtggcgcta gatgagagtg gtgatttctc cctggtggag     4380

gatgacggtc cccccatgag agagatcata ctcaaggtgg tcctgatgac catctgtggc     4440

atgaacccaa tagccatacc ctttgcagct ggagcgtggt acgtatacgt gaagactgga     4500

aaaaggagtg gtgctctatg ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc     4560

acagatggag tgtacagagt aatgactcgt agactgctag gttcaacaca agttggagtg     4620

ggagttatgc aagagggggt ctttcacact atgtggcacg tcacaaaagg atccgcactg     4680

agaagcggtg aagggagact tgatccatac tggggagatg tcaagcagga tctggtgtca     4740

tactgtggtc catggaagct agatgccgcc tgggacgggc acagcgaggt gcagctcttg     4800

gccgtgcccc ccggagagag agcgaggaac atccagactc tgcccggaat atttaagaca     4860

aaggatgggg acattggagc ggttgcgctg gattacccag caggaacttc aggatctcca     4920

atcctagaca agtgtgggag agtgatagga ctttatggca atggggtcgt gatcaaaaat     4980

gggagttatg ttagtgccat cacccaaggg aggagggagg aagagactcc tgttgagtgc     5040

ttcgagcctt cgatgctgaa gaagaagcag ctaactgtct tagacttaca tcctggagct     5100

gggaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaac aagactccgt     5160

actgtgatct tagctccaac cagggttgtc gctgctgaaa tggaggaggc ccttagaggg     5220

cttccagtgc gttatatgac aacagcagtc aatgtcaccc actctggaac agaaatcgtc     5280

gacttaatgt gccatgccac cttcacttca cgtctactac agccaatcag agtccccaac     5340

tataatctgt atattatgga tgaggcccac ttcacagatc cctcaagtat agcagcaaga     5400

ggatacattt caacaagggt tgagatgggc gaggcggctg ccatcttcat gaccgccacg     5460

ccaccaggaa cccgtgacgc atttccggac tccaactcac caattatgga caccgaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacggatca ttctggaaaa     5580

acagtttggt ttgttccaag cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag     5640

gctggaaaac gggtcataca gctcagcaga aagacttttg agacagagtt ccagaaaaca     5700

aaacatcaag agtgggactt tgtcgtgaca actgacattt cagagatggg cgccaacttt     5760

aaagctgacc gtgtcataga ttccaggaga tgcctaaagc cggtcatact tgatggcgag     5820

agagtcattc tggctggacc catgcctgtc acacatgcca gcgctgccca gaggaggggg     5880

cgcataggca ggaatcccaa caaacctgga gatgagtatc tgtatggagg tgggtgcgca     5940

gagactgacg aagaccatgc acactggctt gaagcaagaa tgctccttga caatatttac     6000

ctccaagatg gcctcatagc ctcgctctat cgacctgagg ccgacaaagt agcagccatt     6060

gagggagagt tcaagcttag gacggagcaa aggaagacct ttgtggaact catgaaaaga     6120

ggagatcttc ctgtttggct ggcctatcag gttgcatctg ccggaataac ctacacagat     6180

agaagatggt gctttgatgg cacgaccaac aacaccatac tggaagacag tgtgccggca     6240

gaggtgtgga ccagacacgg agagaaaaga gtgctcaaac cgaggtggat ggacgccaga     6300

gtttgttcag atcatgcggc cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga     6360

gcggcttttg gagtgatgga agccttggga acactgccag gacacatgac agagagattc     6420

caggaagcca ttgacaacct cgctgtgctc atgcgggcag agactggaag caggccttac     6480

aaagccgcgg cggcccaatt gccggagacc ctagagacca ttatgctttt ggggttgctg     6540

ggaacagtct cgctgggaat ctttttcgtc ttgatgagga acaagggcat agggaagatg     6600

ggctttggaa tggtgaccct tggggccagt gcatggctca tgtggctctc ggaaattgag     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgttcctat tgctggtggt gctcatacct     6720

gagccagaaa agcaaagatc tccccaggac aaccaaatgg caatcatcat catggtagca     6780

gtaggtcttc tgggcttgat taccgccaat gaactcggat ggttggagag aacaaagagt     6840

gacctaagcc atctaatggg aaggagagag gagggagcaa ccataggatt ctcaatggac     6900

attgacctgc ggccagcctc agcttgggcc atctatgctg ccttgacaac tttcattacc     6960

ccagccgtcc aacatgcagt gaccacttca tacaacaact actccttaat ggcgatggcc     7020

acgcaagctg gagtgttgtt tggtatgggc aaagggatgc cattctacgc atgggacttt     7080

ggagtcccgc tgctaatgat aggttgctac tcacaattaa cacccctgac cctaatagtg     7140

gccatcattt tgctcgtggc gcactacatg tacttgatcc cagggctgca ggcagcagct     7200

gcgcgtgctg cccagaagag aacggcagct ggcatcatga agaaccctgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa aaagatggga     7320

caggtgctac tcatagcagt agccgtctcc agcgccatac tgtcgcggac cgcctggggg     7380

tggggggagg ctggggccct gatcacagcc gcaacttcca ctttgtggga aggctctccg     7440

aacaagtact ggaactcctc tacagccact tcactgtgta acatttttag gggaagttat     7500

ttggctggag cttctctaat ctacacagta acaagaaacg ctggcttggt caagagacgt     7560

gggggtggaa caggagagac cctgggagag aaatggaagg cccgcttgaa ccagatgtcg     7620

gccctggagt tctactccta caaaaagtca ggcatcactg aggtgtgcag agaagaggcc     7680

cgccgcgccc tcaaggacgg tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca     7740

aagctgagat ggttggtgga gcggggatac ctgcagccct atggaaaggt cattgatctt     7800

ggatgtggca gagggggctg gagttactac gccgccacca tccgcaaagt tcaagaagtg     7860

aaaggataca caaaaggagg ccctggtcat gaagaacccg tgttggtgca aagctatggg     7920

tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt     7980

gacacgttgc tgtgtgacat aggcgagtca tcatctagtc ctgaagtgga agaagcacgg     8040

acgctcagag tcctctccat ggtgggggat tggcttgaaa gaagaccagg agccttttgt     8100

ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt     8160

aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac     8220

tgggtctctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctc     8280

ttggggcgca tggacgggcc taggaggcca gtgaaatatg aggaggatgt gaatctcggc     8340

tctggcacgc gggctgtggt aagctgcgct gaagctccca acatgaagat cattggtaac     8400

cgcattgaaa ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca     8460

tataggacat gggcttacca tggaagctat gaggccccca cacaagggtc agcgtcctct     8520

ctaataaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca     8580

ggaatagcca tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg     8640

gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc     8700

tggttgtgga aagagctagg caaacacaaa cggccacgag tctgtaccaa agaagagttc     8760

atcaacaagg ttcgtagcaa tgcagcatta ggggcaatat ttgaagagga aaaagagtgg     8820

aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga     8880

gagcaccacc tgagaggaga gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggcta     9000

ggggctagat ttctagagtt cgaagccctt ggattcttga acgaggatca ctggatgggg     9060

agagagaact caggaggtgg tgttgaaggg ctgggattac aaagactcgg atatgtccta     9120

gaagagatga gttgcatacc aggaggaagg atgtatgcag atgacactgc tggctgggac     9180

acccgcatca gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa     9240

gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag     9300

gtccttagac cagctgaaaa agggaaaaca gttatggaca ttatttcaag acaagaccaa     9360

agggggagcg gacaagttgt cacttacgct cttaacacat ttaccaacct agtggtgcaa     9420

ctcattcgga atatggaggc tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg     9480

aggtcagaga aagtgaccaa ctggttgcag agcaacggat gggataggct caaacgaatg     9540

gcagtcagtg gagatgattg cgttgtgaag ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa accctcaact     9660

ggatgggaca actgggaaga agttccgttt tgctcccacc acttcaacaa gctccatctc     9720

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgggcc     9780

cgcgtctctc caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     9840

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc     9900

atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt    10020

gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat    10080

ttgggaaaaa gggaagactt gtggtgtgga tctctcatag ggcacagacc gcgcaccacc    10140

tgggctgaga acattaaaaa cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagtt cgctacttgg gtgaagaagg gtctacacct    10260

ggagtgctgt aa                                                        10272


<210>  73
<211>  10272
<212>  DNA
<213>  Zika virus strain ArD158084 polyprotein gene, complete cds

<400>  73
atgaaaaacc caaagaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt gggaggtttg aagaggttgc cagccggact tctgctgggt      120

catggaccca tcagaatggt tttggcgata ctagcctttt tgagatttac agcaatcaag      180

ccatcactgg gccttatcaa cagatggggt tccgtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaagag      300

aggaagagac gtggcgcaga caccagcatc ggaatcattg gcctcctgct gactacagcc      360

atggcagcag agatcactag acgcgggagt gcatactaca tgtacttgga taggagcgat      420

gccgggaagg ccatttcgtt tgctaccaca ttgggagtga acaagtgcca cgtacagatc      480

atggacctcg ggcacatgtg tgacgccacc atgagttatg agtgccctat gctggatgag      540

ggagtggaac cagatgatgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc atcacaaaaa aggtgaggca cggcgatcta gaagagccgt gacgctccct      660

tctcactcta caaggaagtt gcaaacgcgg tcgcagacct ggttagaatc aagagaatac      720

acgaagcact tgatcaaggt tgaaaactgg atattcagga accccgggtt tgcgctagtg      780

gccgttgcca ttgcctggct tttgggaagc tcgacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagt atcaggtgca ttggagtcag caatagagac      900

ttcgtggagg gcatgtcagg tgggacctgg gttgatgttg tcttggaaca tggaggctgc      960

gttaccgtga tggcacagga caagccaaca gttgacatag agttggtcac gacgacggtt     1020

agtaacatgg ccgaggtaag atcctattgc tacgaggcat cgatatcgga catggcttcg     1080

gacagtcgtt gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacattagt ggacagaggt tggggaaatg gttgtggact ttttggcaaa     1200

gggagcttgg tgacatgtgc caagttcacg tgttctaaga agatgaccgg gaagagcatt     1260

caaccggaaa atctggagta tcggataatg ctatcagtgc atggctccca gcatagcggg     1320

atgattgtca atgatatagg acatgaaact gacgaaaaca gagcgaaagt cgaggttacg     1380

cctaattcac caagagcgga agcaaccttg ggaggctttg gaagcttagg acttgactgt     1440

gaaccaagga caggccttga cttttcagat ctgtattacc tgaccatgaa caataagcat     1500

tggttggtgc acaaagagtg gtttcatgac atcccattgc cttggcatgc tggggcagac     1560

accggaactc cacactggaa caacaaagag gcattggtag aattcaagga tgcccacgcc     1620

aagaggcaaa ccgtcgtcgt tctggggagc caggaaggag ccgttcacac ggctctcgct     1680

ggagctctag aggctgagat ggatggtgca aagggaaggc tgttctctgg ccatttgaaa     1740

tgccgcctaa aaatggacaa gcttagattg aagggcgtgt catattcctt gtgcactgcg     1800

gcattcacat tcaccaaggt cccagctgaa acactgcatg gaacagtcac agtggaggtg     1860

cagtatgcag ggacagatgg accctgcaag gtcccagccc agatggcggt ggacatgcag     1920

accctgaccc cagttggaag gctgataacc gccaaccccg tgattactga aagcactgag     1980

aactcaaaga tgatgttgga gcttgaccca ccatttgggg attcttacat tgtcatagga     2040

gttggggaca agaaaatcac ccaccactgg cataggagtg gtagcaccat cggaaaggca     2100

tttgaagcca ctgtgagagg cgccaagaga atggcagtcc tgggggatac agcctgggac     2160

ttcggatcag tcgggggtgt gttcaactca ctgggtaagg gcattcacca gatttttgga     2220

gcagccttca aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcacg     2280

ctgctagtgt ggttaggttt gaacacaaag aatggatcta tctccctcac atgcttggcc     2340

ctggggggag tgatgatctt cctctccacg gctgtttctg ctgacgtggg gtgctcagtg     2400

gacttctcaa aaagagaaac gagatgtggc acgggggtat tcatctataa tgatgttgaa     2460

gcctggaggg accggtacaa gtaccatcct gactcccccc gcagattggc agcagcagtc     2520

aagcaggcct gggaagaggg gatctgtggg atctcatccg tttcaagaat ggaaaacatc     2580

atgtggaaat cagtagaagg ggagctcaat gctatcctag aggagaatgg agttcaactg     2640

acagttgttg tgggatctgt aaaaaacccc atgtggagag gtccacaaag attgccagtg     2700

cctgtgaatg ggctgcccca tggctggaaa gcctggggga aatcgtattt tgttagggcg     2760

gcaaagacca acaacagttt tgttgtcgac ggtgacacac tgaaggaatg tccgcttaag     2820

cacagagcat ggaatagttt tcttgtggag gatcacgggt ttggagtctt ccacaccagt     2880

gtttggctta aggtcagaga agattactca ttagaatgtg acccagccgt cataggaaca     2940

gctgttaagg gaagggaggc cgcgcacagt gatctgggct attggattga aagtgaaaag     3000

aatgacacat ggaggctgaa gagggcccac ctgattgaga tgaaaacatg tgaatggcca     3060

aagtctcaca cattgtggac agatggagta gaagaaagtg atcttatcat acccaagtct     3120

ttagctggtc cactcagcca ccacaacacc agagagggtt acagaaccca agtgaaaggg     3180

ccatggcaca gtgaagagct tgaaatccgg tttgaggaat gtccaggcac caaggttcac     3240

gtggaggaga catgcggaac tagaggacca tctctgagat caactactgc aagtggaagg     3300

gtcattgagg aatggtgctg tagggaatgc acaatgcccc cactatcgtt tcgagcaaaa     3360

gacggctgct ggtatggaat ggagataagg cccaggaaag aaccagagag caacttagtg     3420

aggtcaatgg tgacagcggg gtcaaccgat catatggacc acttctctct tggagtgctt     3480

gtgattctac tcatggtgca ggaggggttg aagaagagaa tgaccacaaa gatcatcatg     3540

agcacatcaa tggcagtgct ggtagtcatg atcttgggag gattttcaat gagtgacctg     3600

gccaagcttg tgatcctgat gggtgctact ttcgcagaaa tgaacactgg aggagatgta     3660

gctcacttgg cattggtagc ggcatttaaa gtcagaccag ccttgctggt ctccttcatt     3720

ctcagagcca attggacacc ccgtgagagc atgctgctag ccctggcttc gtgtcttctg     3780

caaactgcga tctctgctct tgaaggtgac ttgatggtcc tcgttaatgg atttgctttg     3840

gcctggttgg caattcgagc aatggccgtg ccacgcactg acaacatcgc tctagcaatc     3900

ttggctgctc taacaccact agctcgaggc acactgctcg tggcatggag agcgggcctg     3960

gctacttgtg gagggttcat gctcctctcc ctgaaaggga aaggtagtgt gaagaagaac     4020

ctgccatttg tcatggccct gggattgaca gctgtgaggg tagtagaccc tattaatgtg     4080

gtaggactac tgttactcac aaggagtggg aagcggagct ggccccctag tgaagttctc     4140

acagccgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga cattgagatg     4200

gctggaccca tggctgcagt aggcttgcta attgtcagct atgtggtctc gggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaggacgc ggaagtcact     4320

ggaaacagtc ctcggcttga cgtggcactg gatgagagtg gtgatttctc cttggtagag     4380

gaagatggtc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc     4440

atgaacccaa tagctatacc ttttgctgca ggagcgtggt atgtgtatgt gaagactggg     4500

aaaaggagtg gcgccctctg ggacgtgcct gctcccaaag aagtgaagaa aggagagacc     4560

acagatggag tgtacagagt gatgactcgc agactgctag gttcaacaca ggttggagtg     4620

ggagtcatgc aagagggagt cttccacacc atgtggcacg ttacaaaagg agccgcactg     4680

aggagcggtg agggaagact tgatccatac tggggggatg tcaagcagga cttggtgtca     4740

tactgtgggc cttggaagtt ggatgcagct tgggatggac ttagcgaggt acagcttttg     4800

gccgtacctc ccggagagag ggccagaaac attcagaccc tgcctggaat attcaagaca     4860

aaggacgggg acatcggagc agttgctctg gactaccctg cagggacctc aggatctccg     4920

atcctagaca aatgtggaag agtgatagga ctctatggca atggggttgt gatcaagaat     4980

ggaagctatg ttagtgctat aacccaggga aagagggagg aggagactcc ggttgaatgt     5040

ttcgaaccct cgatgctgaa gaagaagcag ctaactgtcc tggatctgca tccaggagcc     5100

ggaaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaaa gagactccgg     5160

acagtgatct tggcaccaac tagggttgtc gctgctgaga tggaggaagc cttgagagga     5220

cttccggtgc gttacatgac aacagcagtc aacgtcaccc attctgggac agaaatcgtt     5280

gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat     5340

tacaatctca acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga     5400

ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca     5460

ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacagacca ttctgggaaa     5580

acagtttggt tcgttccaag cgtgagaaac ggaaatgaaa tcgcagcctg tctgacaaag     5640

gctggaaagc gggtcataca gctcagcagg aagacttttg agacagaatt tcagaaaaca     5700

aaaaatcaag agtgggactt tgtcataaca actgacatct cagagatggg cgccaacttc     5760

aaggctgacc gggtcataga ctctaggaga tgcctaaaac cagtcatact tgatggtgag     5820

agagtcatct tggctgggcc catgcctgtc acgcatgcta gtgctgctca gaggagagga     5880

cgtataggca ggaaccctaa caaacctgga gatgagtaca tgtatggagg tgggtgtgca     5940

gagactgatg aaggccatgc acactggctt gaagcaagaa tgcttcttga caacatctac     6000

ctccaggatg gcctcatagc ctcgctctat cggcctgagg ccgataaggt agccgccatt     6060

gagggagagt ttaagctgag gacagagcaa aggaagacct tcgtggaact catgaagaga     6120

ggagaccttc ccgtctggct agcctatcag gttgcatctg ccggaataac ttacacagac     6180

agaagatggt gctttgatgg cacaaccaac aacaccataa tggaagacag tgtaccagca     6240

gaggtttgga caaagtatgg agagaagaga gtgctcaaac cgagatggat ggatgctagg     6300

gtctgttcag accatgcggc cctgaagtcg ttcaaagaat tcgccgctgg aaaaagagga     6360

gcggctttgg gagtaatgga ggccctggga acactgccag gacacatgac agagaggttt     6420

caggaagcca ttgacaacct cgccgtgctc atgcgagcag agactggaag caggccttat     6480

aaggcagcgg cagcccaact gccggagacc ctagagacca ttatgctctt aggtttgctg     6540

ggaacagttt cactggggat cttctttgtc ttgatgcgga ataagggcat cgggaagatg     6600

ggctttggaa tggtaaccct tggggccagt gcatggctca tgtggctttc ggaaattgaa     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgtttttat tactggtggt gctcataccc     6720

gagccagaga agcaaagatc tccccaagat aaccagatgg caattatcat catggtggca     6780

gtgggccttc taggtttgat aactgcaaac gaacttggat ggctggaaag aacaaaaaat     6840

gacatagctc atctaatggg aaggagagaa gaaggagcaa ccatgggatt ctcaatggac     6900

attgatctgc ggccagcctc cgcctgggct atctatgccg cattgacaac tctcatcacc     6960

ccagctgtcc aacatgcggt aaccacttca tacaacaact actccttaat ggcgatggcc     7020

acacaagctg gagtgctgtt tggcatgggc aaagggatgc cattttatgc atgggacttt     7080

ggagtcccgc tgctaatgat gggttgctat tcacaattaa cacccctgac tctgatagta     7140

gctatcattc tgcttgtggc gcactacatg tacttgatcc caggcctaca agcggcagca     7200

gcgcgtgctg cccagaaaag gacagcagct ggcatcatga agaatcccgt tgtggatgga     7260

atagtggtaa ctgacattga cacaatgaca atagaccccc aggtggagaa gaagatggga     7320

caagtgttac tcatagcagt agccatctcc agtgctgtgc tgctgcggac cgcctgggga     7380

tggggggagg ctggagctct gatcacagca gcgacctcca ccttgtggga aggctctcca     7440

aacaaatact ggaactcctc tacagccacc tcactgtgca acatcttcag aggaagctat     7500

ctggcaggag cttcccttat ctatacagtg acgagaaacg ctggcctggt taagagacgt     7560

ggaggtggga cgggagagac tctgggagag aagtggaaag ctcgtctgaa tcagatgtcg     7620

gccctggagt tctactctta taaaaagtca ggtatcactg aagtgtgtag agaggaggct     7680

cgccgtgccc tcaaggatgg agtggccaca ggaggacatg ccgtatcccg gggaagtgca     7740

aagctcagat ggttggtgga gagaggatat ctgcagcccc atgggaaggt tgttgacctc     7800

ggatgtggca gagggggctg gagctattat gccgccacca tccgcaaagt gcaggaggtg     7860

agaggataca caaagggagg tcccggtcat gaagaaccca tgctggtgca aagctatggg     7920

tggaacatag ttcgtctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt     7980

gacactctgc tgtgtgacat aggtgagtca tcatctagtc ctgaagtgga agagacacga     8040

acactcagag tgctctctat ggtgggggac tggcttgaaa aaagaccagg ggccttctgt     8100

ataaaggtgc tgtgcccata caccagcact atgatggaaa ccatggagcg actgcaacgt     8160

aggcatgggg gaggattagt cagagtgcca ttgtctcgca actccacaca tgagatgtac     8220

tgggtctctg gggcaaaaag caacatcata aaaagtgtgt ccaccacaag tcagctcctc     8280

ctgggacgca tggatggccc caggaggcca gtgaaatatg aggaggatgt gaacctcggc     8340

tcgggtacac gagctgtggc aagctgtgct gaggctccta acatgaaaat catcggcagg     8400

cgcattgaga gaatccgcaa tgaacatgca gaaacatggt ttcttgatga aaaccaccca     8460

tacaggacat gggcctacca tgggagctac gaagccccca cgcaaggatc agcgtcttcc     8520

ctcgtgaacg gggttgttag actcctgtca aagccttggg acgtggtgac tggagttaca     8580

ggaatagcca tgactgacac cacaccatac ggccaacaaa gagtcttcaa agaaaaagtg     8640

gacaccaggg tgccagatcc ccaagaaggc actcgccagg taatgaacat ggtctcttcc     8700

tggctgtgga aggagctggg gaaacgcaag cggccacgcg tctgcaccaa agaagagttt     8760

atcaacaagg tgcgcagcaa tgcagcactg ggagcaatat ttgaagagga aaaagaatgg     8820

aagacggctg tggaagctgt gaatgatcca aggttttggg ccctagtgga tagggagaga     8880

gaacaccacc tgagaggaga gtgtcacagc tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaagcaag gagagttcgg gaaagcaaaa ggtagccgcg ccatctggta catgtggttg     9000

ggagccagat tcttggagtt tgaagccctt ggattcttga acgaggacca ttggatggga     9060

agagagaact ctggaggcgg agttgaagga ctgggactgc agagactggg ctatgtcctt     9120

gaggagatga gccaggcacc aggagggaag atgtacgcag atgacactgc tggctgggac     9180

acccgcatta gtaagtttga tctggagaat gaagctttga ttaccaacca aatggaggaa     9240

gggcacagaa ctctggcgtt ggccgtgatt aaatacacat accaaaacaa agtggtgaag     9300

gtcctcagac cagctgaagg aggaaaaaca gttatggaca tcatttcaag acaagaccag     9360

agagggagtg gacaagttgt cacttatgct ctcaacacat tcaccaactt ggtggtgcag     9420

cttatccgga acatggaagc tgaggaagtg ttagagatgc aagacttatg gctgttgagg     9480

aagccagaga aagtgaccag atggttgcag agcaatggat gggatggact caaacgaatg     9540

gcggtcagtg gagatgactg cgttgtgaag ccaatcgatg ataggtttgc acatgccctc     9600

aggttcttga atgacatggg aaaagttagg aaagacacac aggagtggaa accctcgact     9660

ggatggagca attgggaaga agtcccgttc tgctcccacc acttcaacaa gctgtacctc     9720

aaggatggga gatccattgt ggtcccttgc cgccaccaag atgaactgat tggccgagct     9780

cgcgtttcac caggggcagg atggagcatc cgggagactg cctgtcttgc aaaatcatat     9840

gcgcagatgt ggcagctcct ttatttccac agaagagacc ttcgactgat ggctaatgcc     9900

atttgctcgg ctgtaccagt tgactgggta ccaactggga gaaccacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaggac atgctcatgg tgtggaatag agtgtggatt    10020

gaggagaacg accatatgga ggacaagact cctgtaacaa aatggacaga cattccctat    10080

ctaggaaaaa gggaggactt atggtgtgga tcccttatag ggcacagacc ccgcaccact    10140

tgggctgaaa acatcaaaga cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actatctatc cacccaagtc cgctacttgg gtgaggaagg gtccacaccc    10260

ggagtgttgt aa                                                        10272


<210>  74
<211>  10272
<212>  DNA
<213>  Zika virus strain ArD157995 polyprotein gene, complete cds


<220>
<221>  misc_feature
<222>  (2711)..(2711)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8487)..(8487)
<223>  n is a, c, g, or t

<400>  74
atgaaaaacc caaagaagaa atccggaaga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt gggaggtttg aagaggttgc cagccggact tctgctgggt      120

catggaccca tcagaatggt tttggcgata ctagcctttt tgagatttac agcaatcaag      180

ccatcactgg gccttatcaa cagatggggt tccgtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaagag      300

aggaagagac gtggcgcaga caccagcatc ggaatcattg gcctcctgct gactacagcc      360

atggcagcag agatcactag acgcgggagt gcatactaca tgtacttgga taggagcgat      420

gccgggaagg ccatttcgtt tgctaccaca ttgggagtga acaagtgcca cgtacagatc      480

atggacctcg ggcacatgtg tgacgccacc atgagttatg agtgccctat gctggatgag      540

ggagtggaac cagatgatgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc atcacaaaaa aggtgagaca cggcgatcta gaagatctgt gtcgctccgt      660

tatcactata caaggaagtt gcaaacgcgg tcgcagacat ggttagaatc aagagaatac      720

aagaagcact tgatcatggt cgaaaactgg atattcagga accccgggtt tgccatagtg      780

tccgttgcca ttacctggct gatgggaagc ttgacgagcc aaaaagtcat atacttggtc      840

atgatagtgt tgattgtccc ggcatacagt atcagctgca ttggagtcag caatagagac      900

ttagtggagg gcatgtcagg tgggacctgg gttgatgttg tcttggaaca tggagggtgc      960

gttaccgaga tggcacagga caagccaaca gttgacatag agttggtcac gatgacggtt     1020

agtaacatgg ccgaggtaag atcctattgc tacgaggcat cgttatccga catggcttcg     1080

gccagtcgtt gcccaacaca aggcgaaccc tccctcgaca agcaatcaga cactcaatct     1140

gtatgcaaaa gaacattagg agacagaggt tggggaaatg gttgtgggat ttttggcaaa     1200

gggagcttgg tgacatgttc caagttcacg tgttgtaaga agatgcccgg gaagagcatt     1260

caaccggaaa atctggagta tcggataatg ctcccagtgc atggctccca gcatagcggg     1320

atgattgtga atgacatagg acatgaaact gacgaaaaca gagcgaaagt cgaggtcaca     1380

cccaattcac caagagcaga agcaaccttg ggaggttttg gaagcttggg acttgactgt     1440

gaaccaagga caggccttga cttctcagat ctgtattatc tgaccatgaa caacaagcat     1500

tggttggtgc acaaggagtg gtttcatgac atcccattac cttggcatgc tggtgcagac     1560

actggaactc cacactggaa caacaaagag gcattggtgg agttcaagga cgcccacgcc     1620

aagaggcaaa ctgttgtggt tctggggagc caagagggag ctgttcacac ggccctcgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tattctctgg ccatttgaaa     1740

tgccgcctaa aaatggacaa gcttaggttg aagggtgtgt catattccct gtgtactgca     1800

gcgttcacat ttaccaaggt cccagctgaa acattgcatg gaacagttac agtggaggtg     1860

cagtctgcag ggacagatgg accctgcaag gtcccagccc agatggcggt ggacatgcag     1920

accctgaccc cagttggaag gctgataacc gccaaccccg tgattactga aagcactgag     1980

aactcaaaga tgatgttgga gcttgaccca ccatttgggg attcttacat tgtcatagga     2040

gttggggaca agaaaatcac ccaccactgg cataggagtg gtagcaccat cggaaaggca     2100

tttgaagcca ctgtgagagg cgccaagaga atggcagtcc tgggggatac agcctgggac     2160

ttcggatcag tcgggggtgt gttcaactca ctgggtaagg gcattcacca gatttttgga     2220

gcagccttca aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcacg     2280

ctgctagtgt ggttaggttt gaacacaaag aatggatcta tctccctcac atgcttggcc     2340

ctggggggag tgatgatctt cctctccacg gctgtttctg ctgacgtggg gtgctcagtg     2400

gacttctcaa aaaaggaaac gagatgtggc acgggggtat tcatctataa tgatgttgaa     2460

gcctggaggg accggtacaa gtaccatcct gactcccccc gcagattggc agcagcagtc     2520

aagcaggcct gggaagaggg gatctgtggg atctcatccg tttcaagaat ggaaaacatc     2580

atgtggaaat cagtagaagg ggagctcaat gctatcctag aggagaatgg agttcaactg     2640

acagttgttg tgggatctgt aaaaaacccc atgtggagag gtccacaaag attgccagtg     2700

cctgtgaatg ngctgcccca tggctggaaa gcctggggga aatcgtattt tgttagggcg     2760

gcaaagacca acaacagttt tgttgtcgac ggtgacacac tgaaggaatg tccgcttaag     2820

cacagagcat ggaatagttt tcttgtggag gatcacgggt ttggagtctt ccacaccagt     2880

gtttggctta aggtcagaga agattactca ttagaatgtg acccagccgt cataggaaca     2940

gctgttaagg gaagggaggc cgcgcacagt gatctgggct attggattga aagtgaaaag     3000

aatgacacat ggaggctgaa gagggcccac ctgattgaga tgaaaacatg tgaatggcca     3060

aagtctcaca cattgtggac agatggagta gaagaaagtg atcttatcat acccaagtct     3120

ttagctggtc cactcagcca ccacaacacc agagagggtt acagaaccca agtgaaaggg     3180

ccatggcaca gtgaagagct tgaaatccgg tttgaggaat gtccaggcac caaggttcac     3240

gtggaggaga catgcggaac tagaggacca tctctgagat caactactgc aagtggaagg     3300

gtcattgagg aatggtgctg tagggaatgc acaatgcccc cactatcgtt tcgagcaaaa     3360

gacggctgct ggtatggaat ggagataagg cccaggaaag aaccagagag caacttagtg     3420

aggtcaatgg tgacagcggg gtcaaccgat catatggacc acttctctct tggagtgctt     3480

gtgattctac tcatggtgca ggaggggttg aagaagagaa tgaccacaaa gatcatcatg     3540

agcacatcaa tggcagtgct ggtagtcatg atcttgggag gattttcaat gagtgacctg     3600

gccaagcttg tgatcctgat gggtgctact ttcgcagaaa tgaacactgg aggagatgta     3660

gctcacttgg cattggtagc ggcatttaaa gtcagaccag ccttgctggt ctccttcatt     3720

ctcagagcca attggacacc ccgtgagagc atgctgctag ccctggcttc gtgtcttctg     3780

caaactgcga tctctgctct tgaaggtgac ttgatggtcc tcgttaatgg atttgctttg     3840

gcctggttgg caattcgagc aatggccgtg ccacgcactg acaacatcgc tctagcaatc     3900

ttggctgctc taacaccact agctcgaggc acactgctcg tggcatggag agcgggcctg     3960

gctacttgtg gagggttcat gctcctctcc ctgaaaggga aaggtagtgt gaagaagaac     4020

ctgccatttg tcatggccct gggattgaca gctgtgaggg tagtagaccc tattaatgtg     4080

gtaggactac tgttactcac aaggagtggg aagcggagct ggccccctag tgaagttctc     4140

acagccgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga cattgagatg     4200

gctggaccca tggctgcagt aggcttgcta attgtcagct atgtggtctc gggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaggacgc ggaagtcact     4320

ggaaacagtc ctcggcttga cgtggcactg gatgagagtg gtgatttctc cttggtagag     4380

gaagatggtc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc     4440

atgaacccaa tagctatacc ttttgctgca ggagcgtggt atgtgtatgt gaagactggg     4500

aaaaggagtg gcgccctctg ggacgtgcct gctcccaaag aagtgaagaa aggagagacc     4560

acagatggag tgtacagagt gatgactcgc agactgctag gttcaacaca ggttggagtg     4620

ggagtcatgc aagagggagt cttccacacc atgtggcacg ttacaaaagg agccgcactg     4680

aggagcggtg agggaagact tgatccatac tggggggatg tcaagcagga cttggtgtca     4740

tactgtgggc cttggaagtt ggatgcagct tgggatggac ttagcgaggt acagcttttg     4800

gccgtacctc ccggagagag ggccagaaac attcagaccc tgcctggaat attcaagaca     4860

aaggacgggg acatcggagc agttgctctg gactaccctg cagggacctc aggatctccg     4920

atcctagaca aatgtggaag agtgatagga ctctatggca atggggttgt gatcaagaat     4980

ggaagctatg ttagtgctat aacccaggga aagagggagg aggagactcc ggttgaatgt     5040

ttcgaaccct cgatgctgaa gaagaagcag ctaactgtcc tggatctgca tccaggagcc     5100

ggaaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaaa gagactccgg     5160

acagtgatct tggcaccaac tccagttgag agatcatact caaggtggtc cttgtggcca     5220

tctgtggcac gtacccagac aacagcagtc aacgtcaccc attctgggac agaaatcgtt     5280

gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat     5340

tacaatctca acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga     5400

ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca     5460

ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacagacca ttctgggaaa     5580

acagtttggt tcgttccaag cgtgagatct ggagaagaaa gcgcagcctg tctgacaaag     5640

gctggaaagc gggtcataca gctcagcagg aagacttttg agacagaatt tcagaaaaca     5700

aaaaatcaag agtgggactt tgtcataaca actgacatct cagagatggg cgccaacttc     5760

aaggctgacc gggtcataga ctctaggaga tgcctaaagc cagtcatact tgatggtgag     5820

agagtcatct tggctgggcc catgcctgtc acgcatgcta gtgctgctca gaggagagga     5880

cgtataggca ggaaccctaa caaacctgga gatgagtaca tgtatggagg tgggtgtgca     5940

gagactgatg aagaccatgc acactggctt gaagcaagaa tgcttcttga caacatctac     6000

ctccaggatg gcctcatagc ctcgctctat cggcctgagg ccgataaggt agccgccatt     6060

gagggagagt ttaagctgag gacagagcaa aggaagacct tcgtggaact catgaagaga     6120

ggagaccttc ccgtctggct agcctatcag gttgcatctg ccggaataac ttacacagac     6180

agaagatggt gctttgatgg cacaaccaac aacaccataa tggaagacag cgtaccagca     6240

gaggtgtgga caaagtatgg agagaagaga gtgctcaaac cgagatggat ggatgctagg     6300

gtctgttcag accatgcggc cctgaagtcg ttcaaagaat tcgccgctgg aaaaagagga     6360

gcggctttgg gagtaatgga ggccctggga acactgccag gacacatgac agagaggttt     6420

caggaagcca ttgacaacct cgccgtgctc atgcgagcag agactggaag caggccttat     6480

aaggcagcgg cagcccaact gccggagacc ctagagacca ttatgctctt aggtttgctg     6540

ggaacagttt cactggggat cttcttcgtc ttgatgcgga ataagggcat cgggaagatg     6600

ggctttggaa tggtaaccct tggggccagt gcatggctca tgtggctttc ggaaattgaa     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgtttttat tactggtggt gctcataccc     6720

gagccagaga agcaaagatc tccccaagat aaccagatgg caattatcat catggtggca     6780

gtgggccttc taggtttgat aactgcaaac gaacttggat ggctggaaag aacaaaaaat     6840

gacatagctc atctaatggg aaggagagaa gaaggagcaa ccatgggatt ctcaatggac     6900

attgatctgc ggccagcctc cgcctgggct atctatgccg cattgacaac tctcatcacc     6960

ccagctgtcc aacatgcggt aaccacttca tacaacaact actccttaat ggcgatggcc     7020

acacaagctg gagtgctgtt tggcatgggc aaagggatgc catttatgca tggggacctt     7080

ggagtcccgc tgctaatgat gggttgctat tcacaattaa cacccctgac tctgatagta     7140

gctatcattc tgcttgtggc gcactacatg tacttgatcc caggcctaca agcggcagca     7200

gcgcgtgctg cccagaaaag gacagcagct ggcatcatga agaatcccgt tgtggatgga     7260

atagtggtaa ctgacattga cacaatgaca atagaccccc aggtggagaa gaagatggga     7320

caagtgttac tcatagcagt agccatctcc agtgctgtgc tgctgcggac cgcctgggga     7380

tggggggagg ctggagctct gatcacagca gcgacctcca ccttgtggga aggctctcca     7440

aacaaatact ggaactcctc tacagccacc tcactgtgca acatcttcag aggaagctat     7500

ctggcaggag cttcccttat ctatacagtg acgagaaacg ctggcctggt taagagacgt     7560

ggaggtggga cgggagagac tctgggagag aagtggaaag ctcgtctgaa tcagatgtcg     7620

gccctggagt tctactctta taaaaagtca ggtatcactg aagtgtgtag agaggaggct     7680

cgccgtgccc tcaaggatgg agtggccaca ggaggacatg ccgtatcccg gggaagtgca     7740

aagctcagat ggttggtgga gagaggatat ctgcagcccc atgggaaggt tgttgacctc     7800

ggatgtggca gagggggctg gagctattat gccgccacca tccgcaaagt gcaggaggtg     7860

agaggataca caaagggagg tcccggtcat gaagaaccca tgctggtgca aagctatggg     7920

tggaacatag ttcgtctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt     7980

gacactctgc tgtgtgacat aggtgagtca tcatctagtc ctgaagtgga agagacacga     8040

acactcagag tgctctctat ggtgggggac tggcttgaaa aaagaccagg ggccttctgt     8100

ataaaggtgc tgtgcccata caccagcact atgatggaaa ccatggagcg actgcaacgt     8160

aggcatgggg gaggattagt cagagtgcca ttgtctcgca actccacaca tgagatgtac     8220

tgggtctctg gggcaaaaag caacatcata aaaagtgtgt ccaccacaag tcagctcctc     8280

ctgggacgca tggatggccc caggaggcca gtgaaatatg aggaggatgt gaacctcggc     8340

tcgggtacac gagctgtggc aagctgtgct gaggctccta acatgaaaat catcggcagg     8400

cgcattgaga gaatccgcaa tgaacatgca gaaacatggt ttcttgatga aaaccaccca     8460

tacaggacat gggcctacca tgggagntac gaagccccca cgcaaggatc agcgtcttcc     8520

ctcgtgaacg gggttgttag actcctgtca aagccttggg acgtggtgac tggagttaca     8580

ggaatagcca tgactgacac cacaccatac ggccaacaaa gagtcttcaa agaaaaagtg     8640

gacaccaggg tgccagatcc ccaagaaggc actcgccagg taatgaacat ggtctcttcc     8700

tggctgtgga aggagctggg gaaacgcaag cggccacgcg tctgcaccaa agaagagttt     8760

atcaacaagg tgcgcagcaa tgcagcactg ggagcaatat ttgaagagga aaaagaatgg     8820

aagacggctg tggaagctgt gaatgatcca aggttttggg ccctagtgga tagggagaga     8880

gaacaccacc tgagaggaga gtgtcacagc tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaagcaag gagagttcgg gaaagcaaaa ggtagccgcg ccatctggta catgtggttg     9000

ggagccaggt ttctggagtt tgaatcactg gggtttctga atgaagatca ctggatggga     9060

agagagaact ctggaggcgg agttgaagga ctgggactgc agagactggg ctatgtcctt     9120

gaggagatga gccaggcacc aggagggaag atgtacgcag atgacactgc tggctgggac     9180

acccgcatta gtaagtttga tctggagaat gaagctttga ttaccaacca aatggaggaa     9240

gggcacagaa ctctggcgtt ggccgtgatt aaatacacat accaaaacaa agtggtgaag     9300

gtcctcagac cagctgaagg aggaaaaaca gttatggaca tcatttcaag acaagaccag     9360

agagggagtg gacaagttgt cacttatgct ctcaacacat tcaccaactt ggtggtgcag     9420

cttatccgga acatggaagc tgaggaagtg ttagagatgc aagacttatg gctgttgagg     9480

aagccagaga aagtgaccag atggttgcag agcaatggat gggatagact caaacgaatg     9540

gcggtcagtg gagatgactg cgttgtgaag ccaatcgatg ataggtttgc acatgccctc     9600

aggttcttga atgacatggg aaaagttagg aaagacacac aggagtggaa accctcgact     9660

ggatggagca attgggaaga agtcccgttc tgctcccacc acttcaacaa gctgtacctc     9720

aaggatggga gatccattgt ggtcccttgc cgccaccaag atgaactgat tggccgagct     9780

cgcgtttcac caggggcagg atggagcatc cgggagactg cctgtcttgc aaaatcatat     9840

gcgcagatgt ggcagctcct ttatttccac agaagagacc ttcgactgat ggctaatgcc     9900

atttgctcgg ctgtaccagt tgactgggta ccaactggga gaaccacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaggac atgctcatgg tgtggaatag agtgtggatt    10020

gaggagaacg accatatgga ggacaagact cctgtaacaa aatggacaga cattccctat    10080

ctaggaaaaa gggaggactt atggtgtgga tcccttatag ggcacagacc ccgcaccact    10140

tgggctgaaa acatcaaaga cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actatctatc cacccaagtc cgctacttgg gtgaggaagg gtccacaccc    10260

ggagtgttgt aa                                                        10272


<210>  75
<211>  10272
<212>  DNA
<213>  Zika virus strain ArD128000 polyprotein gene, complete cds


<220>
<221>  misc_feature
<222>  (1324)..(1338)
<223>  n is a, c, g, or t

<400>  75
atgaaaaacc caaagaggaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt ggggggtttg aagaggctgc cagccggact tctgctgggt      120

catggaccca ttagaatggt tttggcgata ctagcctttt tgagatttac agcaatcaag      180

ccatcactgg gcctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggagata      240

ataaagaagt ttaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaggag      300

aggaagagac gtggtgcaga caccagtatc ggaatcattg gcctcctgct gactacagcc      360

atggcagcag agattactag acgaggaagt gcatactaca tgtacttgga caggagcgat      420

gctgggaagg ccatttcctt tgctaccaca ttgggagtga acaaatgcca tgtacagatc      480

atggatctcg ggcacatgtg tgacgccacc atgagttatg agtgccctat gctagacgaa      540

ggagtggaac cagatgatgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc atcacaaaaa aggtgaagca cggcgatcta gaagagctgt gacgctccct      660

tctcactcca caaggaagtt gcaaacgcgg tcgcagacct ggttagaatc aagagaatac      720

acgaagcact tgatcaaggt tgaaaactgg atattcagga accccgggtt tgcgctagcg      780

gctgttgcca ttgcttggct tctgggaagc tcgacgagcc aaaaagtcat atacttggtc      840

atgatattgt tgattgcccc ggcatacagc atcaggtgca taggagttag caatagagat      900

ttcgtagagg gcatgtcagg tgggacctgg gttgatgtcg tcttggaaca tgggggttgc      960

gtcaccgtga tggcacagga caagccaaca gttgacatcg agttggtcac gacaacggtt     1020

agcaacatgg ccgaggtaag atcctactgc tatgaggcat caatatcgga catggcctcg     1080

gacagccgct gtccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacattagt ggacagaggt tggggaaacg gttgtggact ttttggcaaa     1200

gggagcttgg tgacatgtgc caagtttacg tgttctaaga agatgaccgg gaagagcatt     1260

cagccggaga acttggagta ccggataatg ctatcagtgc atggatccca gcacagtggg     1320

atgnnnnnnn nnnnnnnngg acatgaaact gacgaaaaca gagcaaaggt cgaggtcaca     1380

cccaattcac caagagcaga agcaaccttg ggaggttttg gaagcttggg acttgactgt     1440

gaaccaagga caggccttga cttctcagat ctgtattatc tgaccatgaa caacaagcat     1500

cggttggtgc gcaaggagtg gtttcatgac atcccattac cttggcatgc tggtgcagac     1560

actggaactc cacactggaa caacaaagag gcattggtgg agttcaagga cgctcacgcc     1620

aagaggcaaa ctgttgtggt tctggggagc caagagggag ctgttcacac ggccctcgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tattctctgg ccatttgaaa     1740

tgccgcctaa aaatggacaa gcttaggttg aagggtgtgt catattccct gtgtactgca     1800

gcgttcacat ttaccaaggt cccagctgaa acattgcatg gaacagttac agtggaggtg     1860

cagtatgcag ggacagatgg accttgcaag gtcccagccc agatggcggt ggacatgcag     1920

actctgaccc cagttggaag gctgataacc gccaaccctg tgatcactga aagtactgag     1980

aattcaaaga tgatgttgga acttgaccca ccatttgggg attcttacat tgtcatagga     2040

gtcggggaca agaaaatcac ccatcactgg ctcaagaaag ggagctccat cggaaaggca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggggacac agcctgggac     2160

tttggatcag ttggaggtgt gtttaattca ttgggtaagg gtgttcatca gatctttgga     2220

gcagctttca aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcaca     2280

ctgttggtgt ggttgggtct gaacacaaag aatggatcta tctccctcac atgcttagcc     2340

ctggggggag tgatgatttt cctttccacg gctgtttctg ctgatgttgg gtgctcggtg     2400

gacttctcaa aaaaggaaac gagatgtggc acgggggtgt tcgtctacaa tgacgttgaa     2460

gcctggaggg accgttacaa gtatcatcct gactcccccc gcagattggc agcagctgtt     2520

aagcaggctt gggaagaggg gatttgtggg atctcctccg tttcgagaat ggaaaacatc     2580

atgtggaaat cagtggaagg ggagcttaat gcaatcctag aggagaatgg agtccaactg     2640

acagttgtag tggggtctgt aaaaaacccc atgtggagag gtccacaaag attgccagtg     2700

cccgtgaatg agctgcccca tggctggaaa gcctggggga aatcgtactt tgtcagagcg     2760

gcaaagacca acaacagttt tgttgtcgac ggagacacac tgaaggagtg tccgctcaaa     2820

catagagcat ggaatagctt ccttgtggag gatcacgggt ttgggatttt ccacaccagt     2880

gtttggctga aggtcagaga ggactactca ttagagtgtg acccagccgt cataggaaca     2940

gctgtcaagg gaaaggaagc tgcacacagt gatctatgct attggattga gagtgaaaag     3000

aatgacacat ggaggctgag gagggcccac ctgattgaga tgaaaacatg tgaatggcca     3060

aagtctcaca cattgtggac agatggagta gaagaaagtg atcttatcat acccaagtct     3120

ttagctggtc cactcagcca ccacaacacc agagagggtt acagaaccca agtgaaaggg     3180

ccatggcaca gtgaagagct tgaaatccgg tttgaggaat gtccaggcac caaggtttac     3240

gtggaggaga catgcggaac tagaggacca tctctgagat caactactgc aagtggaagg     3300

gtcattgagg aatggtgctg tagggaatgc acaatgcccc cactatcgtt tcgagcaaaa     3360

gacggctgct ggtatggaat ggagataagg cccaggaaag aaccagagag caacttagtg     3420

aggtcaatgg tgacagcggg gtcaaccgat catatggacc acttctctct tggagtgctt     3480

gtgattctac tcatggtgca ggaggggttg aagaagagaa tgaccacaaa gatcatcatg     3540

agcacatcaa tggcagtgct ggtagccatg gtcttgggag gattctcaat gagtgatctg     3600

gctaagcttg tgatcctgat gggtgccact ttcgcagaaa tgaacactgg aggagatgtg     3660

gctcacttgg cattggttgc ggcatttaaa gtcagaccag ccttgttggt ttcctttatc     3720

ttcagagcca actggacacc ccgtgagagc atgctgctag ccctggcttc gtgtctcctg     3780

cagactgcga tctccgctct tgaaggcgag ctgatggtcc tcgttaatgg atttgctttg     3840

gcctggttgg caatacgagc aatggccgtg ccacgcactg acaatatcgc tctagcaact     3900

ctggccgctt taacaccatt ggccagaggc acactgctcg tggcatggag agcgggcctc     3960

gccacttgtg gagggttcat gcttctttcc ctgaaaggga aaggtagtgt gaagaagaac     4020

ctgccttttg tcatggcctt ggggttggcc gctgtgagga tagtggaccc catcaatgtg     4080

gtaggactac tgttactcac aaggagtgga aaacggagct ggccccccag tgaagtgctt     4140

acagctgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga catagagatg     4200

gctgggccca tggctgcagt aggcctgcta attgtcagtt atgtggtctc gggaaagagt     4260

gtggacatgt acatcgaaag agcaggtgat atcacatggg aaaaagacgc ggaagtcact     4320

ggaaacagtc cccggcttga cgtggcactg gatgagagtg gtgatttctc cttggtagag     4380

gaggatggcc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc     4440

atgaacccaa tagccatacc cttcgctgca ggagcgtggt atgtgtatgt aaagactggg     4500

aaaaggagtg gtgccctctg ggacgtgcct gctcccaaag aagtgaaaaa aggagagact     4560

acagatggag tgtacagagt gatgactcgc agactgctgg gttcaacaca ggttggagtg     4620

ggggtcatgc aagagggagt cttccacacc atgtggcacg tcacaaaagg agctgcattg     4680

aggagcggtg aaggaagact tgatccatat tggggggacg tcaagcagga cttggtgtca     4740

tattgtgggc cgtggaagtt ggacgcaacc tgggatggac taagtgaagt gcagcttttg     4800

gccgtacccc ccggagagag ggctagaaac attcagactc tgcctggaat attcaagaca     4860

aaggatgggg acatcggagc ggttgctcta gactaccccg caggaacctc aggatctcca     4920

atcctagaca aatgcggaag agtgatagga ctttatggca atggggttgt gatcaagaat     4980

ggaagctatg tcagtgcaat aacccaggga aaaagggagg aggaggcccc agttgagtgc     5040

tttgaaccct cgatgctgag gaagaagcag ctaacagtct tggatctgca tccaggagcc     5100

ggaaaaacca ggagggttct tcctgaaata gtccgtgaag ccataaaaaa gagactccgg     5160

acagtgatct tggcaccaac tagggttgtc gctgctgaga tggaggaggc cttgagagga     5220

cttccggtgc gttacatgac aacagcagtc aacgtcaccc attctgggac agaaatcgtt     5280

gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat     5340

tacaatctca acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga     5400

ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca     5460

ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacagacca ttctgggaaa     5580

acaatttggt ttgttccaag tgtgagaaac ggaaatgaaa tcgcagcctg tctgacaaag     5640

gctggaaagc gggttataca gctcagcagg aagacttttg agacagagtt tcagaagaca     5700

aaaaatcaag agtgggactt tgtcataaca actgacattt cagagatggg tgccaatttc     5760

aaggctgacc gggtcatcga ttccaggaga tgcctaaagc cagtcatact tgatggtgag     5820

agagtcatcc tggctgggcc catgcctgtc acgcatgcca gtgctgctca gaggagagga     5880

cgtataggca ggaaccccaa caaacccgga gatgagtaca tgtatggagg tgggtgtgca     5940

gagactgatg aagaccatgc acactggctt gaagcaagaa tgcttcttga caacatttac     6000

ctccaagatg gcctcatagc ctcgctctat cggcctgagg ccgacaaggt agccgccatt     6060

gagggagagt tcaagctgag gacagagcaa aggaagacct ttgtggaact catgaagaga     6120

ggagaccttc ccgtttggct ggcctatcaa gtagcatctg ccggaataac ttacacagac     6180

agaagatggt gctttgatgg cactaccaac aacaccataa tggaagacag tgtaccagca     6240

gaggtgtgga ccaagtatgg agagaagaga gtgcttaaac cgaggtggat ggatgctagg     6300

gtctgttcag atcatgcggc tctgaagtcg ttcaaagaat ttgccgctgg gaagagagga     6360

gcggctttgg gagtaatgga tgccctggga acattgccag gacacatgac agagaggttt     6420

caggaagcca ttgacaatct tgctgtgctc atgcgagcag agactggaag taggccctac     6480

aaagcagcgg cagctcaact gccggagacc ctagagacca tcatgctttt gggcttattg     6540

ggaacagttt cgctaggaat cttctttgtc ttgatgcgga acaagggcat cgggaagatg     6600

ggcttcggaa tggtaaccct tggggccagc gcatggctca tgtggctctc ggaaattgaa     6660

ccagccagaa tcgcatgtgt cctcattgtc gtgtttttgt tactggtggt gctcataccc     6720

gagccagaga agcaaagatc tccccaggat aatcaaatgg caatcatcat catggtggca     6780

gttggccttt tgggtttgat aactgcaaat gaactcggat ggctggaaag gacaaaaagt     6840

gatatagctt atctgatggg aaggaaagaa gaggggacaa ccataggatt ctcaatggat     6900

attgatctgc ggccagcctc tgcctgggct atttatgccg cattgacaac tctcatcacc     6960

ccagccgtcc aacatgcggt aaccacctca tacaacaact actccctgat ggcgatggcc     7020

acacaagctg gagtgctgtt tggcatgggc aaagggatgc cattttatgc atgggacttt     7080

ggagtcccgc tgctaatgat aggttgctac tcacagttaa cacccctgac cctgatagta     7140

gccatcattc tgcttgtagc acactacatg tacttgatcc caggtttgca ggcagcagca     7200

gcacgtgctg cccagaagag gacagcagct ggcatcatga aaaatcccgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa gaagatggga     7320

caagtgttac tcatagcagt agctgtctcc agtgctgtgc tgctgcggac cgctggggga     7380

tggggggagg ctggggctct gatcacagca gctacctcca ccttatggga aggctctcca     7440

aacaaatact ggaactcctc tacagccacc tcactatgca acatctttag aggaagttat     7500

ttggcagggg cttcccttat ttacacagtg acaagaaatg ccggtctggt taagagacgt     7560

ggaggtggaa cgggagagac cctgggagag aagtggaaag cccgcctgaa ccagatgtcg     7620

gccctggagt tttactctta caaaaagtca ggcatcaccg aagtgtgtag ggaggaggcg     7680

cgccgcgctc tcaaggatgg agtggccaca ggagggcatg ctgtatcccg gggaagcgca     7740

aagcttagat ggttggtaga gagaggatac ctgcagcccc atggaaaggt tgttgacctt     7800

ggatgtggca gaggaggctg gagttattac gctgccacta tccgtaaagt gcaggaggtc     7860

agaggataca caaagggagg tcctggtcat gaagaaccca tgctggtgca aagctatggg     7920

tggaacatag ttcgcctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt     7980

gacactctgc tgtgtgacat aggcgagtca tcatctagtc ctgaagtgga agagacgcga     8040

acactcagag tgctctccat ggtagaagac tggcttgaga aaagaccagg ggccttctgc     8100

ataaaggtgc tgtgcccata caccagcaca atgatggaga ccatggagcg actgcaacgt     8160

aggcatgggg gaggattggt cagagtgcca ttgtcccgca actccacaca tgagatgtat     8220

tgggtctctg gagccaaaag taacatcata aagagtgtgt ccaccacaag tcagctcctc     8280

ttgggacgca tggatgggcc taggaggcca gtgaaatatg aggaggatgt gaacctcggc     8340

tcaggcacac gagctgtggc aagctgcgct gaggctccca acatgaagat cattggtagg     8400

cgcattgaga gaatccgcaa tgaacatgca gagacatggt tctttgatga aaaccaccca     8460

tacaggacat gggcctacca tgggagctac gaagccccca cgcaggggtc agcgtcatcc     8520

ctcgtgaatg gggttgttag actcttgtca aagccctggg atgtggtgac tggagttaca     8580

ggaatagcta tgactgacac cacgccatac ggccaacaaa gagtcttcaa ggaaaaagtg     8640

gacacaaggg tgccagatcc ccaagaaggc actcgccaag taatgaacat agtttcgtct     8700

tggctatgga aggagctagg aaaacgcaag cgaccacgtg tctgcaccaa agaagagttc     8760

atcaataagg tgcgcagcaa tgcagcactg ggagcaatat ttgaagagga aaaagaatgg     8820

aagacagctg tagaagctgt gaatgatcca agattttggg ctctagtgga caaggaaaga     8880

gaacaccacc tgagaggaga gtgtcacagc tgtgtgtaca acatgatggg taaaagagaa     8940

aagaagcaag gagaattcgg gaaagcaaaa ggcagccgcg caatctggta catgtggttg     9000

ggagccagat ttttggagtt tgaagctctt ggattcttga acgaggatca ctggatggga     9060

agagaaaact caggaggtgg tgttgaaggg ctaggactgc aaaggcttgg atatatccta     9120

gaagaaatga accgggcacc aggaggaaag atgtatgcag atgacaccgc tggctgggac     9180

acccgtatta gtaagtttga tctagagaat gaagccctga tcactaacca gatggaagaa     9240

gggcacagag ctctggcgtt ggccgtgatt aaatacacat accaaaacaa agtggtgaag     9300

gttctcagac cagctgaagg agggaaaaca gtcatggaca tcatctcaag acaagaccag     9360

agagggagtg gacaagttgt tacttatgcc ctcaacacat tcaccaacct ggtggtgcag     9420

cttatccgga acatggaggc tgaggaagtg ctagagatgc atgatctgtg gttgttgagg     9480

aaaccagaga aagtgaccag atggttgcag agtaatggat gggacagact caaacggatg     9540

gcagttagtg gagatgactg cgttgtaaag ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgacatggg aaaggttagg aaagacacac aggaatggaa gccctcgact     9660

ggatggagca attgggagga ggtcccgttc tgttctcacc acttcaacaa gctgcacctc     9720

aaggacggga gatccattgt ggtcccctgc cgccaccaag atgaactgat tggccgagcc     9780

cgtgtctcac caggggcagg atggagcatc cgtgagactg cttgccttgc aaaatcatat     9840

gcacagatgt ggcagcttct ttatttccac agaagagatc tccgactgat ggccaatgcc     9900

atttgttcgg ctgtgccagt tgattgggta ccaactggga gaaccacctg gtcaatccat     9960

ggaaagggag aatggatgac tactgaggac atgctcatgg tgtggaatag agtgtggatt    10020

gaggagaacg accacatgga ggacaagacc cctgttccaa aatggacaga aattccctac    10080

ttggggaaaa gggagtccct atggtgtgga tacattatag ggcacagacc tcgcaccact    10140

tgggctgaga acatcaaaga cacagtcaac atggtgctta ggctcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagta cgctacttgg gtgaggaagg gtccacacct    10260

ggagtgctgt aa                                                        10272


<210>  76
<211>  10272
<212>  DNA
<213>  Zika virus strain ArD7117 polyprotein gene, complete cds


<220>
<221>  misc_feature
<222>  (4309)..(4309)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5225)..(5226)
<223>  n is a, c, g, or t

<400>  76
atgaaaaacc caaagaagag atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt ggggggtttg aagaggctgc cggccggact tctgctgggc      120

catggaccca tcagaatggt tttggcgata ctagcctttt tgagattcac agcaatcaag      180

ccatcactgg gcctcatcaa tagatggggt tccgtgggga agaaggaggc tatggaaata      240

ataaaaaagt tcaagaaaga ccttgctgcc atgttgagaa ttatcaatgc taggaaggag      300

aggaagagac gtggcgctga caccagcatc ggaatcgtcg gcctcctgct gaccacagcc      360

atggcagccg agatcaccag acgtgggagt gcatactaca tgtacttgga caggagcgat      420

gctggtaagg ccatttcttt tgctaccaca ttgggggtga acaaatgcca tgtacagatc      480

atggacctcg ggcacatgtg tgacgccacc atgagttatg agtgccccat gctggacgag      540

ggagtggagc cagatgacgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc aacataaaaa aggtgaagca cgacgatcca gaagagccgt gacgcttcct      660

tctcactcca caaggaagct gcaaacgcga tcacagactt ggctagaatc aagagaatac      720

acaaagcacc tgatcaaggt tgagaattgg atattcagga accccgggtt tgcgctagtg      780

gctgtagcta ttgcctggct cctgggaagc tcgacgagcc aaaaagtcat atacttggta      840

atgatattgt tgattgcccc ggcatacagc atcaggtgca taggagttag caatagagac      900

ttcgtggagg gcatgtcagg tgggacctgg gttgatgttg tcttggaaca tgggggttgc      960

gtcaccgtga tggcacagga caagccaaca gttgacatcg agttggtcac gacaacggtt     1020

agcaacatgg ccgaggtaag atcctactgc tatgaggcat caatatcgga catggcttcg     1080

gacagccgct gtccaacaca aggtgaagcc taccttgaca agcagtcaga cactcaatat     1140

gtctgcaaga gaacattggt ggatagaggt tggggaaatg ggtgtggact ttttggcaaa     1200

gggagcttgg tgacatgtgc caagtttacg tgctccaaga aaatgacagg caagagcatc     1260

cagccggaga acttggagta ccggataatg ctatcagtgc atggatccca gcacagtggg     1320

atgattgtga atgacatagg acatgaaact gacgaaaaca gagcaaaagt cgaggtcaca     1380

cccaattcac caagagcaga agcaaccttg ggaggttttg gaagcttggg acttgactgt     1440

gaaccaagga caggccttga cttctcagat ctgtattacc tgaccatgaa caataagcat     1500

tggttggtgc acaaggagtg gtttcatgac atcccattac cttggcatgc tggtgcagac     1560

actggaactc cacactggaa caacaaagag gcattggtgg agtttaagga cgcccacgcc     1620

aagaggcaaa ctgttgtggt tctggggagc caagagggag ctgttcacac ggccctcgct     1680

ggagctttgg aggctgagat ggatggtgca aagggaaggc tattctctgg ccatttgaaa     1740

tgccgcctaa aaatggacaa gcttaggttg aagggtgtgt catattccct gtgtaccgca     1800

gtgtgtaccg cagcgaaggt cccagctgaa acattgcatg gaacagtcac agtggaggtg     1860

cagtatgcag ggacagatgg accctgcaag gtcccagccc agatggcggt agacatgcag     1920

accctgaccc cagttggaag gctgataacc gccaaccctg tgatcactga aagtactgag     1980

aattcaaaga tgatgttgga gctcgaccca ccatttgggg attcttacat tgtcatagga     2040

gtcggggaca agaaaatcac ccatcactgg catcggagtg gtagcaccat cggaaaggca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggggacac agcctgggac     2160

tttggatcag ttgggggtgt gtttaattca ttgggtaagg gtattcacca gatctttgga     2220

gcagctttta aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcaca     2280

ctgttggtgt ggttaggtct gaacacaaag aatggatcta tctccctcac atgcttagcc     2340

ctggggggag tgatgatctt cctttccacg gctgtttctg ctgatgttgg gtgctcggtg     2400

gacttctcaa aaaaggaaac gagatgtggc acgggggtgt tcgtctacaa tgacgttgaa     2460

gcctggaggg accggtacaa gtaccatcct gactcccccc gcagattggc agcagctgtc     2520

aagcaggctt gggaagaggg gatttgtggg atctcctccg tttcgagaat ggaaaacatc     2580

atgtggaaat cagtggaagg ggagcttaat gcaatcctag aggagaatgg agtccaactg     2640

acagttgtag tggggtctgt aaaaaaccct atgtggagag gtccacaaag attgccagtg     2700

cccgtgaatg agctgcccca tggctggaaa gcctggggga aatcgtactt tgtcagagcg     2760

gcaaagacca acaacagttt tgttgtcgac ggtgacacac tgaaggagtg tccgctcaaa     2820

catagagcat ggaatagctt ccttgtggag gatcacgggt ttgggatctt ccacaccagt     2880

gtttggctga aggtcagaga ggactactca ttagagtgtg acccagccgt cataggaaca     2940

gctgtcaagg gaaaggaagc tgcacacagt gatctaggct attggattga gagtgaaaag     3000

aatgacacat ggaggctgag gagggctcat ctgattgaga tgaaaacatg tgagtggcca     3060

aagtctcaca cactgtggac agatggagtg gaagaaagtg atctgatcat acccaagtcc     3120

ttagctggtc cactcagcca ccacaacacc agagagggtt acagaactca agtgaaaggg     3180

ccatggcata gtgaagagct cgaaatccgg tttgaggagt gcccaggaac caaggttcac     3240

gtggaggaga catgcggaac tagaggacca tctctgagat caactactgc aagtggaagg     3300

gtcatagagg aatggtgctg tagggaatgc acaatgcctc cactatcgtt ccgggcgaaa     3360

gacggctgct ggtatggaat ggagataagg cccagaaagg aaccagagag caacttagta     3420

aggtctatgg tgacagcagg atcaaccgat catatggatc acttctctct tggagtgctt     3480

gtgattctac tcatggtgca ggaaggtttg aagaagagaa tgaccacaaa gatcataatg     3540

agcacatcaa tggcagtgct ggtagccatg gtcttgggag gattctcaat gagtgacctg     3600

gctaagcttg tgatcctgat gggtgccact ttcgcagaaa tgaacactgg aggagatgtg     3660

gctcacttgg cattggttgc ggcatttaaa gtcagaccag ccttgttggt ttccttcatc     3720

ttcagagcca actggacacc ccgtgagagc atgctgctag ccctggcttc gtgtctcctg     3780

cagactgcga tctccgctct tgaaggcgag ctgatggtcc tcgttaatgg atttgctttg     3840

gcctggttgg caatacgagc aatggccgtg ccacgcactg acaatatcgc tctagcaatt     3900

ctggctgctc taacaccatt agccagaggc acactgctcg tggcatggag agcgggcctc     3960

gccacttgtg gagggttcat gctcctttcc ctgaaaggga aaggtagtgt gaagaagaac     4020

ctgccttttg tcatggcctt ggggttgacc gctgtgagga tagtggaccc catcaatgtg     4080

gtaggactac tgttactcac acggagtgga aaacggagct ggccccctag tgaagtgctt     4140

acagctgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga tatagagatg     4200

gctgggccca tggctgcagt aggcctgcta attgtcagtt atgtggtctc gggaaagagt     4260

gtggacatgt acatcgaaag agcaggtgat atcacatggg aaaaagacnc ggaagtcact     4320

ggaaacagtc ctcggcttga cgtggcacta gatgagagtg gtgatttctc cttggtagag     4380

gaggatggcc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc     4440

atgaacccaa tagccatacc cttcgctgca ggagcgtggt atgtgtatgt aaagactgga     4500

aaaaggagtg gtgccctctg ggacgtgcct gctcccaaag aagtgaaaaa aggagagact     4560

acagatggag tgtacagagt gatgactcgc agactgctgg gttcaacaca ggttggagtg     4620

ggagtcatgc aagagggagt cttccacacc atgtggcacg tcacaaaagg agccgcattg     4680

aggagcggtg aaggaagact tgatccatat tggggggacg tcaagcagga cttggtgtca     4740

tattgtgggc cgtggaagtt ggatgcagcc tgggatggac taagtgaagt gcagcttttg     4800

gccgtacccc ccggagagag ggctagaaac attcagactc tgcctggaat attcaagaca     4860

aaggatgggg acatcggagc agtcgctcta gactaccccg caggaacctc aggatctcca     4920

atcctagaca aatgcggaag agtgatagga ctttatggca atggggttgt gatcaagaat     4980

ggaagctatg ttagtgccat aacccaggga aaaagggagg aggaggctcc agttgagtgc     5040

tttgaaccct cgatgctgag gaagaagcag ctaacagtct tggatctgca tccaggagcc     5100

gggaaaacca ggagggttct tcctgaaata gtccgtgaag ccataaagaa gagacttcgc     5160

acattgatcc tagcaccaac cagggtcgtt gctgctgaga tggaggaagc cctaagagga     5220

cttcnngtgc gttacatgac aacagcagtc aacgtcaccc attctgggac agaaatcgtt     5280

gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat     5340

tacaatctca acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga     5400

ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca     5460

ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgactggg tgacggacca ttctgggaaa     5580

acaatttggt ttgttccaag tgtgagatct ggagaagaaa gcgcagcctg tctgacaaag     5640

gctggaaagc gggttataca gctcagcagg aagacttttg agacagagtt tcagaagaca     5700

aaaaatcaag agtgggactt tgtcataaca actgacattt cagagatggg tgccaatttc     5760

aaggctgacc gggtcataga ttccaggaga tgcctaaagc cagtcatact cgatggtgag     5820

agagtcatcc tggctgggcc catgcctgtc acgcatgcca gtgctgctca gaggagagga     5880

cgtataggca ggaaccccaa caaacctgga gatgagtaca tgtatggagg tgggtgtgca     5940

gagactgatg aagaccatgc acactggctt gaagcaagaa tgcttcttga caacatttac     6000

ctccaggatg gcctcatagc ctcgctctat cggcctgagg ccgacaaggt agccgccatt     6060

gagggagagt tcaagctgag gacagagcaa aggaagacct ttgtggaact catgaagaga     6120

ggagaccttc ccgtttggct ggcctatcaa gtagcatctg ccggaataac ttacacagac     6180

agaagatggt gctttgatgg cactaccaac aacaccataa tggaagacag tgtaccagca     6240

gaggtgtgga ccaagtatgg agagaagaga gtgcttaaac cgaggtggat ggatgctagg     6300

gtctgttcag atcatgcggc tttgaagtcg ttcaaagaat ttgccgctgg gaagagagga     6360

gcggctttgg gagtgatgga tgccctggga acattgccag gacacatgac agagaggttt     6420

caggaagcca ttgacaatct cgctgtgctc atgcgagcag agactggaag taggccctac     6480

aaagcagcgg cagctcaact gccggagacc ctagagacca tcatgctttt gggcttattg     6540

ggaacagttt cgctaggaat cttctttgtc ttgatgcgga acaagggcat cgggaagatg     6600

ggcttcggaa tggtaaccct tggggccagc gcatggctca tgtggctttc ggaaattgaa     6660

ccagccagaa tcgcatgtgt cctcattgtc gtgtttttgt tactggtggt gctcataccc     6720

gagccagaga agcaaagatc tccccaggat aatcaaatgg caatcatcat catggtggca     6780

gttggccttc tgggtttgat aacagcaaat gaactcggat ggctggaaag gacaaaaagt     6840

gatatagctc atctaatggg aaggaaagaa gaggggacaa ccataggatt ctcaatggat     6900

attgatctgc ggccagcctc cgcctgggct atttatgccg cattgacaac tctcatcacc     6960

ccagccgtcc aacatgcggt aaccacctca tacaacaact actccctgat ggcgatggcc     7020

acacaagctg gagtgctgtt tggcatgggc aaagggatgc cattttatgc atgggacttt     7080

ggagtcccgc tgctaatgat gggttgctac tcacaattaa cacccctgac cctgatagtg     7140

gccatcattc tgcttgtggc acactacatg tacttgatcc caggtttgca ggcagcagca     7200

gcacgtgctg cccagaagag gacagcagct ggcatcatga agaatcccgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa gaagatggga     7320

caagtgttac tcatagcagt agctgtctcc agtgctgtgc tgctgcggac cgcttgggga     7380

tggggggagg ctggggctct gatcacagca gcaacctcca ccttatggga aggctctcca     7440

aacaaatact ggaactcctc cacagccacc tcactgtgca acatctttag aggaagttat     7500

ttggcagggg cttcccttat ttacacagtg acaagaaatg ccggtctggt taagagacgt     7560

ggaggtggaa cgggagagac cctgggagag aagtggaaag cccgcctgaa ccagatgtcg     7620

gccttggagt tttactctta caaaaagtca ggcatcaccg aagtgtgtag ggaggaggcg     7680

cgccgcgccc tcaaggatgg agtggccaca ggaggacatg ctgtatcccg gggaagcgca     7740

aagcttagat ggttggtaga gagaggatac ctgcagcccc atggaaaggt tgttgacctt     7800

ggatgtggca gaggaggctg gagttattac gctgccacca tccgtaaagt gcaggaggtc     7860

agaggataca caaagggagg tcctggtcat gaagaaccca tgctggtgca aagctatggg     7920

tggaacatag ttcgcctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt     7980

gacactctgc tgtgtgacat cggcgagtca tcatctagtc ctgaagtgga agagacgcga     8040

acactcagag tgctctccat ggtgggagac tggcttgaga aaagaccagg ggccttctgc     8100

ataaaggtgc tgtgcccata caccagcaca atgatggaga ccatggagcg actgcaacgt     8160

aggcatgggg gaggattggt cagagtgcca ttgtcccgca actccacaca tgagatgtat     8220

tgggtctctg gagccaaaag taacatcata aagagtgtgt ccaccacaag tcagctcctc     8280

ttgggacgca tggatgggcc taggaggcca gtgaaatatg aggaggatgt gaacctcggc     8340

tcaggcacac gagctgtggc aagctgcgct gaggctccca acatgaagat cattggtagg     8400

cgcattgaga gaatccgcaa tgaacatgca gagacatggt tctttgatga aaaccaccca     8460

tacaggacat gggcctacca tgggagctac gaagccccca cgcaggggtc agcgtcatcc     8520

ctcgtgaacg gggttgttag actcttgtca aaaccctggg atgtggtgac tggagttaca     8580

ggaatagcta tgactgacac cacgccatac ggccaacaaa gagtcttcaa ggaaaaagtg     8640

gacactaggg tgccagatcc ccaagaaggc actcgccaag taatgaacat ggtctcgtct     8700

tggctatgga aggagctggg aaaacgcaag cggccacgtg tctgcaccaa agaagagttc     8760

attaataagg tgcgcagcaa tgcagcactg ggagcaatat ttgaagagga aaaagaatgg     8820

aagacagctg tagaagctgt gaatgatcca agattttggg ctctagtgga caaggaaaga     8880

gaacaccacc tgagaggaga gtgtcacagc tgtgtgtaca acatgatggg taaaagagaa     8940

aagaagcaag gagaattcgg gaaagcaaaa ggcagccgcg caatctggta catgtggttg     9000

ggagccagat ttttggagtt tgaagctctt ggattcttga acgaggacca ctggatggga     9060

agagaaaact caggaggtgg cgttgaaggg ctaggactgc aaaggcttgg atatatccta     9120

gaagaaatga accgggcacc aggaggaaag atgtatgcag atgacaccgc tggctgggac     9180

acccgcatta gcaagtttga tctagagaat gaagccctga tcactaacca gatggaagaa     9240

gggcacagag ctctggcgtt ggccgtgatt aaatacacat accaaaacaa agtggtgaag     9300

gttctcagac cagctgaagg agggaaaaca gtcatggaca tcatctcaag acaagaccag     9360

agagggagcg gacaagttgt tacttatgct ctcaacacat tcaccaacct ggtggtgcag     9420

cttatccgga acatggaggc tgaggaagtg ctagagatgc atgatctatg gttgttgagg     9480

aagccagaga aagtgaccag atggttgcag agcaatggat gggacagact caaacggatg     9540

gcagttagtg gagatgactg cgttgtaaag ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgacatggg aaaggttagg aaagacacac aggaatggaa accctcgact     9660

ggatggagca attgggaaga ggtcccgttc tgttctcacc acttcaacaa gctgcacctc     9720

aaggacggga gatccattgt ggtcccctgc cgccaccaag atgaactgat tggccgagcc     9780

cgtgtctcac caggggcagg atggagcatc cgggagactg cttgtcttgc aaaatcatat     9840

gcacagatgt ggcagcttct ttatttccac aaaagagacc tccgactgat ggccaatgcc     9900

atttgttcgg ctgtgccagt tgactgggta ccaactggga gaaccacctg gtcaatccat     9960

ggaaagggag aatggatgac tactgaggac atgctcatgg tgtggaatag agtgtggatt    10020

gaggagaacg accacatgga ggacaagacc cctgtaacaa aatggacaga cattccctat    10080

ttggggaaaa gggaggactt atggtgtgga tcccttatag ggcacagacc tcgcaccact    10140

tgggctgaga acatcaaaga cacagtcaac atggtgcgta ggatcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagta cgctacttgg gtgaggaagg gtccacacct    10260

ggagtgctgt aa                                                        10272


<210>  77
<211>  10272
<212>  DNA
<213>  Zika virus strain ArB1362 polyprotein gene, complete cds


<220>
<221>  misc_feature
<222>  (1336)..(1356)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5225)..(5226)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5229)..(5229)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8947)..(8947)
<223>  n is a, c, g, or t

<400>  77
atgaaaaacc caaagaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt gggaggtttg aagaggctgc cagccggact tctgctgggt      120

catggaccca ttagaatggt tttggcgata ctagcctttt tgagatttac agcaatcaag      180

ccatcactgg gcctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggagata      240

ataaagaagt ttaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaggag      300

aggaagagac gtggtgcaga caccagtatc ggaatcattg gcctcctgct gactacagcc      360

atggcagcag agattactag acgaggaagt gcatactaca tgtacttgga caggagcgat      420

gctgggaagg ccatttcctt tgctaccaca ttgggagtga acaaatgcca tgtacagatc      480

atggatctcg ggcacatgtg tgacgccacc atgagttatg agtgccctat gctagacgaa      540

ggagtggaac cagatgatgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc atcacaaaaa aggtgaagca cggcgatcta gaagagctgt gacgctccct      660

tctcactcca caaggaagtt gcaaacgcgg tcgcagacct ggttagaatc aagagaatac      720

acgaagcact tgatcaaggt tgaaaactgg atattcagga accccgggtt tgcgctagcg      780

gctgttgcca ttgcttggct tctgggaagt tcgacgagcc aaaaagtcat atacttgatc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca ttggagtcag caacagagac      900

ttcgtggaag gcatgtcagg tgggacctgg gttgatgtcg tcttggaaca tggaggttgc      960

gtcaccgtaa tggcacagga caagccaaca gttgacatag agttggtcac gacaacggtt     1020

agcaacatgg ctgaggtaag atcctactgc tacgaggcat caatatcgga catggcttcg     1080

gatagtcgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtttgcaaaa gaacattggt ggacagaggt tggggaaatg ggtgtggact ttttggcaaa     1200

gggagcctgg tgacatgtgc caagttcacg tgttccaaga agatgaccgg gaagagcatc     1260

cagccggaga atctggagta tcgaataatg ctatcggtgc atggctccca gcacagcggg     1320

atgattgtta atgacnnnnn nnnnnnnnnn nnnnnnaaca gagcggaagt cgaggtcacg     1380

cctaattcac caagagcaga agcaaccttg ggaggctttg gaagtttagg acttgattgt     1440

gaaccaagga caggccttga cttttcagat ttgtattacc tgaccatgaa caataagcac     1500

tggttagtcc acaaagagtg gtttcatgac atcccattgc cttggcatgc tggggcagac     1560

accggaactc cacactggaa caacaaagag gcattggtag agttcaagga tgcccacgcc     1620

aagaggcaaa ccgtcgtcgt tctggggagc caggaaggag ctgttcacac ggctcttgct     1680

ggagctttgg aggctgagat ggatggtgca aaaggaaggc tgttctctgg ccatttgaaa     1740

tgccgcctaa aaatggacaa gcttagattg aagggcgtgt catattcctt gtgcaccgca     1800

gcgttcacat tcaccaaggt cccagctgaa acactgcatg gaacagtcac agtggaggtg     1860

cagtatgcag ggacagatgg accctgcaag gtcccagccc agatggcggt ggacatgcag     1920

actttgaccc cagtcggaag gctgataact gccaaccccg tgattactga aagcactgaa     1980

aattcaaaga tgatgttgga gctcgaccca ccatttgggg attcttacat tgtcatagga     2040

gttggagata agaaaatcac ccaccactgg cataggagtg gtagcaccat cggaaaagca     2100

tttgaggcca ctgtgagagg tgccaagaga atggcagttt tgggggacac agcttgggac     2160

tttggatccg tcgggggtgt gttcaactca ttgggcaagg gcatccacca gatctttgga     2220

gcagccttca aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcacg     2280

ctgctagtgt ggttgggctt gaacacaaag aatggatcca tctccctcac atgcttggcc     2340

ctggggggag tgatgatctt cctctccacg gctgtttctg ctgatgtggg gtgctcggtg     2400

gacttctcaa aaagagaaac gagatgtggc acgggggtgt tcgtctacaa tgacgttgaa     2460

gcctggaggg ataggtacaa gtaccatcct gactcccccc gcagattggc agcagcagtc     2520

aagcaggctt gggaagaggg gatttgtggg atctcctccg tttcaagaat ggaaaacatc     2580

atgtggaaat cagtggaagg ggagctcaat gctatcttag aggagaatgg agttcaactg     2640

acagttgttg tgggatctgt aaaaaacccc atgtggagag gtccacaaag attgccagtg     2700

cctgtaaatg agctgcccca tggctggaaa gcctggggga aatcatattt tgtcagagcg     2760

gcaaagacca acaacagttt tgttgtcgac ggtgacacac tgaaggaatg tccgctcaaa     2820

cacagagcat ggaacagttt ccttgtggag gatcacgggt ttggggtctt ccacactagt     2880

gtttggctta aggttagaga agattactca ctagagtgtg acccagccgt cataggaaca     2940

gctgttaagg gaaaggaggc cgcgcacagt gatctaggct actggattga aagtgaaaag     3000

aatgacacat ggaggttgaa gagggcccac ctgattgaga tgaaaacatg tgagtggcca     3060

aagtctcaca cactgtggac agatggagta gaagaaagtg atctgatcat acccaagtct     3120

ttagctggtc cactcagcca ccacaacacc agagagggtt acagaactca ggcaaaaggg     3180

ccatggcata gtgaagagct tgaaatccgg tttgaggaat gtccaggcac caaggttcac     3240

gtggaggaga catgcggaac tagaggacca tctctgagat caaccactgc aagtggaagg     3300

gtcattgagg aatggtgctg tagagaatgc acaatgcccc cactatcatt tcgagcgaaa     3360

gacggctgct ggtatggaat ggagataagg cccaggaaag aaccagagag caatttagtg     3420

aggtcaatgg tgacagcggg atcaaccgat cacatggacc acttctctct tggagtgctt     3480

gtgattctac tcatggtgca ggaagggctg aagaagagaa tgaccacgaa gatcattgtg     3540

agcacatcaa tggcagtgct ggtagccatg atcttgggag gattctcaat gagtgacctg     3600

gctaagcttg tgatcctgat gggtgctact ttcgcagaaa tgaatactgg aggagatgtg     3660

gctcacttgg cattggtcgc ggcattcaaa gtcagaccag ccttgctggt ctccttcatt     3720

ttcagagcca attggacacc ccgtgagagc atgctgctag ccctggcttc gtgtcttttg     3780

caaactgcaa tttcagctct tgaaggtgac ttgatggtcc tcgttaatgg atttgctttg     3840

gcctggttgg caatacgagc aatggccgtg ccacgcactg acaacattgc tctagcaatc     3900

ctggctgctc tgacaccact agcccgaggc acactgctcg tggcatggag agcgggcctc     3960

gccacttgtg gagggttcat gctcctctcc ttgaaaggaa aaggtagtgt gaagaagaac     4020

ctgccatttg tcatggcctt gggaatgacc gctgtgagga tagtggaccc cattaacgtg     4080

gtgggactac tactactcac aaggagtggg aagcggagct ggccccccag tgaagtgctt     4140

acagctgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga cattgagatg     4200

gctgggccca tggctgcagt aggcttgcta attgtcagtt atgtggtctc aggaaagagt     4260

gtggatatgt acattgaaag agcaggtgac atcacatggg aaaaagacgc ggaagttact     4320

ggaaatagtc ctcggcttga cgtggcacta gatgagagtg gtgatttctc tctggtagag     4380

gaagatggtc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc     4440

atgaacccaa tagccatacc ttttgctgca ggagcgtggt atgtgtatgt gaagactggg     4500

aaaaggagtg gtgccctctg ggatgtgcca gctcctaaag aagtgaaaaa aggagagacc     4560

acagatggag tatacagagt gatgacccgc agattgctgg gttcaacaca ggttggagtg     4620

ggagtcatgc aggagggagt cttccacacc atgtggcacg tcacaaaagg agccgcactg     4680

aggagcggtg aagggagact tgatccatac tggggtgatg tcaagcagga cttggtgtca     4740

tactgtgggc cttggaagct ggatgcagct tgggatggac ttagtgaggt gcagctcttg     4800

gcagtacctc ccggagagag ggccagaaac atccagactc tgcctggaat attcaagaca     4860

aaggatgggg acatcggagc agttgctctg gactaccccg caggaacctc aggatctccg     4920

atcctagaca aatgcggaag agtgatagga ctttatggca atggggttgt gatcaagaat     4980

ggaagctatg ttagtgccat aacccaggga aagagggagg aggagactcc ggttgaatgt     5040

ttcgaaccct cgatgctgaa gaagaagcag ctaactgtcc tggacctgca tccaggagcc     5100

ggaaagacta ggagagttct tcctgaaata gtccgtgaag ccataaaaaa gagactccgc     5160

acagtgatct tggctccaac cagggttgtc gctgctgaga tggaggaagc cttgagagga     5220

cttcnngtnc gttacatgac aacagcagtc aacgtcaccc attctgggac agaaatcgtt     5280

gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat     5340

tacaatctca acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga     5400

ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca     5460

ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacagacca ttctgggaaa     5580

acagtttggt tcgttccaag tgtgagaaat ggaaatgaaa tcacagcctg cctgacaaag     5640

gctggaaagc gggtcataca gctcagcagg aagacttttg agacagagtt ccagaaaaca     5700

aaaaaccaag agtgggactt tgtcataaca actgacatct cagagatggg cgccaatttc     5760

aaggctgacc gggtcataga ctctaggaga tgcctaaagc cagtcatact tgatggtgag     5820

agagtcatct tggctgggcc catgcctgtc acgcatgcta gtgctgctca gaggagagga     5880

cgtataggca ggaaccctaa caaacctgga gatgagtaca tgtatggagg tgggtgtgca     5940

gagactgatg aagaccacgc acactggctt gaagcaagaa tgcttcttga caacatctac     6000

ctccaggatg gcctcatagc ctcgctctat cggcctgagg ccgataaggt ggccgccatt     6060

gagggagagt ttaagctgag gacagagcaa aggaagacct ttgtggaact tatgaagaga     6120

ggagaccttc ccgtttggct agcctatcag gttgcatctg ccggaataac ttacacagac     6180

agaagatggt gctttgatgg cacaactaac aacaccataa tggaagacag tgtaccagca     6240

gaggtgtgga caaaatatgg agagaagaga gtgctcaaac caagatggat ggatgctaga     6300

gtctgttcag atcatgccgc cctgaagtcg ttcaaagagt ttgctgccgg gaaaagagga     6360

gcggctttgg gagtaatgga ggccctggga acattgccag gacacatgac agagaggttt     6420

caggaagcca ttgacaatct cgctgtgctt atgcgagcag aaactggaag caggccttac     6480

aaggcagcgg cagccccact gccggagacc ctagagacca tcatgctctt aggtttgctg     6540

ggaacagttt cgttggggat attctttgtc ttgatgcgga acaagggcat cgggaagatg     6600

gggtttggaa tggtaactct tggggccagt gcatggctca tgtggctttc ggaaattgaa     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgtttttgt tactggtggt actcatacct     6720

gagccagaga agcaaagatc tccccaggat aaccagatgg caatcatcat catggtggca     6780

gtgggccttc tggggttgat aactgcaaat gaacttggat ggctggaaag aacaaaaaat     6840

gacatagctc atctaatggg aaggagagaa gaaggagtaa ctatgggatt ctcaatggac     6900

atcgatttga ggccggcctc cgcctgggct atctatgctg cattgacaac tctcatcacc     6960

ccagccgtcc aacatgcggt aaccacttca tataacaact actccttaat ggcgatggcc     7020

acacaagctg gagtgctgtt tggcatgggc aaagggatgc cattttatgc atgggacttt     7080

ggagtcccgc tgctaatgat gggttgctac tcacaattaa cacccctgac cctgatagtg     7140

gctatcattc tgcttgtggc acactacatg tacttgatcc caggcctaca ggcagcagca     7200

gcgcgtgctg cccagaagag aacagcagct ggcatcatga agaatcccgt tgtggatgga     7260

atagtggtaa ctgacattga cacaatgaca attgaccccc aagtggagaa gaagatggga     7320

caagtgttac tcatagcagt agccatctcc agtgctgtgc tgctgcggac tgcttgggga     7380

tggggggaag ctggagctct gatcacagca gcaacctcca ctttgtggga aggttctcca     7440

aacaaatact ggaactcctc tacagccacc tcactgtgca acatctttag aggaagttac     7500

ctggcaggcg cttctcttat ttacacagtg acaagaaatg ctggcctggt caagagacgt     7560

ggaggtggaa cgggagagac tctaggagag aagtggaaag ctcgcctgaa tcagatgtcg     7620

gccctggagt tctactctta caaaaagtcg ggcatcactg aagtgtgtag agaggaggct     7680

cgccgcgccc tcaaggatgg agtggccaca ggaggacatg ctgtatcccg gggaagcgca     7740

aagctcagat ggctggtgga gagaggatac ctgcagcccc atggaaaggt tgttgacctc     7800

ggatgtggca gagggggttg gagctattat gccgctacca tccggaaagt gcaggaggtg     7860

aaaggataca caaagggagg tcccggtcat gaagaaccca tgctggtgca aagctatgga     7920

tggaacatag ttcgtctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt     7980

gatactctgc tgtgtgacat aggtgagtca tcatccagtc ctgaagtaga agagacgcga     8040

acactcagag tgctctctat ggtgggggac tggcttgaaa aaagaccagg ggccttctgc     8100

ataaaggtgc tgtgcccata caccagcact atgatggaga ccatggagcg actgcaacgt     8160

aggtatgggg gaggattagt cagagtgcca ttgtctcgca actccacaca tgagatgtat     8220

tgggtctctg gagcaaaaag caacatcata aaaagtgtgt ccaccacaag ccagctcctc     8280

ctgggacgca tggatgggcc caggaggcca gtgaaatatg aggaggatgt gaacctcggc     8340

tcgggcacac gagctgtggc aagctgtgct gaggctccca acatgaagat cattggtaag     8400

cgcattgaga gaatccgcag tgaacatgca gaaacatggt tctttgatga aaaccaccca     8460

tacaggacat gggcttacca tgggagctac gaagccccca cgcaagggtc agcgtcttcc     8520

ctcgtgaatg gggttgttag gctcctgtca aagccctggg atgtagtgac tggagttaca     8580

ggaatagcta tgactgacac cacaccatat ggccaacaaa gagtcttcaa agaaaaagtg     8640

gacaccaggg tgccagatcc ccaagaaggc actcgccaga caatgaacat ggtctcgtcc     8700

tggctgtgga aggagctggg aaaacgcaag cggccacgcg tctgcaccaa agaagagttc     8760

atcaacaagg tgcgcagcaa tgcagcgctg ggagcaatat ttgaagagga aaaagaatgg     8820

aagacggccg tggaagctgt gaatgatcca aggttttggg ccctagtgga taaggagaga     8880

gagcatcacc taagaggaga gtgtcatagc tgtgtgtaca acatgatggg aaaaagagag     8940

aagaagnaag gagaattcgg gaaagcaaaa ggcagccgcg ccatctggta catgtggttg     9000

ggagccaggt ttctggagtt tgaatcactg gggtttctga atgaagatca ctggatggga     9060

agagagaact caggaggtgg tgtcgaaggg ctaggactgc aaagacttgg atatattcta     9120

gaagaaatga atcgggcacc aggaggaaag atgtatgcag atgacaccgc tggttgggat     9180

acccgcatta gtaagtttga tctggagaat gaagccttga ttaccaacca aatggaggaa     9240

gggcacagag ctctggcgtt ggctgtgatt aaatacacat accaaaacaa agtggtgaag     9300

gtccttagac cagctgaagg aggaaaaaca gttatggaca tcatttcaag acaagaccag     9360

agagggagtg ggcaagttgt cacttatgct ctcaacacgt ttaccaactt agtggtgcag     9420

cttattcgga acatggaggc tgaggaagtg ttagagatgc aagacttatg gctgttgagg     9480

aagccagaga aagtgactag atggttgcag agtaatggat gggacagact caaacgaatg     9540

gcagtcagtg gagatgactg tgttgtgaag ccaattgatg ataggtttgc atgctgcctc     9600

aggttcctaa acgacatggg gaaagttagg aaagacacac aggaatggaa accctcgact     9660

ggatggagca attgggaaga agtccctttc tgctcccacc acttcaacaa gctgcacctc     9720

aaggatggta gatccattgt ggtcccttgc cgccaccaag atgaactgat tggccgagcc     9780

cgtgtatcac caggggcagg atggagcatc cgggagactg cctgtcttgc aaaatcatat     9840

gcacagatgt ggcagcttct ttacttccac agaagagacc ttcgactgat ggccaacgcc     9900

atttgttcgg ctgtgccagt cgactgggta ccaaccggga gaaccacctg gtcaatccac     9960

gggaagggag aatggatgac cactgaggac atgctcatgg tgtggaatag agtgtggatt    10020

gaggagaacg accatatgga ggacaagact cctgtaacaa agtggactga cattccctac    10080

ctgggaaaaa gggaggactt atggtgtgga tcccttatag ggcacagacc ccgcaccact    10140

tgggctgaga acatcaaaga cacagtcaac atggtgcgca ggatcatagg tgatgaagaa    10200

aaatacatgg actacctatc cacccaagtc cgctacttgg gtgaggaagg gtccacacct    10260

ggagtgttgt aa                                                        10272


<210>  78
<211>  10272
<212>  DNA
<213>  Zika virus polyprotein gene, complete cds GenBank: EU545988.1

<400>  78
atgaaaaacc ccaaagaaga aatccggagg atccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt      120

catgggccca tcaggatggt cttggcgata ctagcctttt tgagattcac ggcaatcaag      180

ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaata      240

ataaagaagt tcaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag      300

aagaagagac gaggcacaga tactagtgtc ggaattgttg gcctcctgct gaccacagcc      360

atggcagtgg aggtcactag acgtgggagt gcatactata tgtacttgga cagaagcgat      420

gctggggagg ccatatcttt tccaaccaca ctggggatga acaagtgtta catacagatc      480

atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gttggatgag      540

ggggtagaac cagatgacgt cgattgttgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgcc accacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctcccc      660

tcccattcca ctaggaagct gcaaacgcgg tcgcagacct ggttggaatc aagagaatat      720

acaaagcacc tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca      780

gcagctgcca tcgcctggct tttgggaagt tcaacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac      900

tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt      960

gttaccgtaa tggcacagga caaaccggct gtcgacatag agctggttac aacaacagtc     1020

agcaacatgg cggaggtaag atcctattgc tatgaggcat caatatcgga catggcttcg     1080

gacagccgct gcccaacaca aggtgaagcc taccttgaca agcagtcaga cactcaatat     1140

gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa     1200

gggagcctgg tgacatgcgc taagtttgca tgctccaaga aaatgaccgg gaagagcatc     1260

cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg     1320

atgatcgtta atgacacagg acatgaaact gatgagaata gagcgaaggt tgagataacg     1380

cccaattcac caagagctga agccaccctg gggggttttg gaagcctagg acttgattgt     1440

gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac     1500

tggttggttc acaaggagtg gttccacgac attccattac cttggcatgc tggggcagac     1560

accggaactc cacattggaa caacaaagaa gcattggtag agttcaagga cgcacatgcc     1620

aaaaggcaaa ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa     1740

tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtaccgca     1800

gcgttcacat tcaccaagat cccggctgaa acactgcacg ggacagtcac agtggaggta     1860

cagtacgcag ggacagatgg accctgcaag gttccagctc agatggcggt ggacatgcaa     1920

actctgaccc cagttgggag gctgataacc gctaaccctg taatcactga aagcactgag     1980

aactctaaga tgatgctgga acttgatcca ccatttgggg actcttacat tgtcatagga     2040

gtcggggaga agaagatcac ccatcactgg cacaggagtg gcagcaccat tggaaaagca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggat     2160

tttggatcag ttggaggtgc tctcaactca ttgggcaagg gcatccatca aatttttgga     2220

gcagctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg     2280

ttgctggtgt ggttgggtct gaatacaaag aatggatcta tttcccttac gtgcttggcc     2340

ttagggggag tgttgatctt tttatccaca gccgtctctg ctgatgtggg gtgctcggtg     2400

gacttctcaa agaaggaaac gagatgcggt acgggggtgt tcgtctataa cgacgttgat     2460

gcctggaggg acaggtacaa gtaccatcct gactcccctc gtagattagc agcagcagtc     2520

aagcaagcct gggragatgg gatctgtggg atctcctctg tttcaagaat ggaaaacatc     2580

atgtggagat cagtagaagg ggagctcaac gcaatcctgg aagagaatgg agttcaactg     2640

acggtcgttg tgggatctgt aaaaaacccc atgtggagag gtccacagag attgcccgtg     2700

cctgtgaacg agctgcccca cggctggaag gcttggggga aatcgtactt cgtcagagca     2760

gcaaagacaa ataacagctt tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa     2820

catagagcat ggaacagctt tcttgtggag gatcatgggt tcggggtatt tcacactagt     2880

gtctggctca aggttagaga agattattca ttagagtgtg atccagccgt tattggaaca     2940

gctgctaagg gaaaggaggc tgtgcacagt gatctaggct actggattga gagtgagaag     3000

aatgacacat ggaggctgaa gagggcccac ctgatcgaga tgaaaacatg tgaatggcca     3060

aagtcccaca cattgtggac agatggaata gaagaaagtg atctgatcat acccaagtct     3120

ttagctgggc cactcagcca tcacaacacc agagagggct acaggactca aatgaaaggg     3180

ccatggcaca gtgaagagct tgaaattcgg tttgaggaat gcccaggcac taaggtccac     3240

gtggaggaaa catgtggaac aagaggacca tctctgagat caaccactgc aagcggaagg     3300

gtgatcgagg aatggtgctg cagggaatgc acaatgcccc cactgtcgtt ccgggctaaa     3360

gatggctgtt ggtatggaat ggagataagg cccaggaaag aaccagaaag taacttagta     3420

aggtcaatgg tgactgcagg atcaactgat cacatggatc acttctccct tggagtgctt     3480

gtgattctgc tcatggtgca ggaagggctg aagaagagaa tgaccacaaa gatcatcata     3540

agcacatcaa tggcagtgct ggtagctatg atcctgggag gattttcaat gagtgacctg     3600

gccaagcttg caattttgat gggtgccacc tttgcggaaa tgaacactgg aggagatgta     3660

gctcatctgg cgctgatagc ggcattcaaa gtcagacctg cgttgctggt atctttcatc     3720

ttcagagcta attggacacc ccgtgagagc atgctgctgg ccctggcttc gtgtcttctg     3780

caaactgcga tctccgcctt ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg     3840

gcctggttgg caatacgagc gatggttgtt ccacgcactg acaacatcac cttggcaatc     3900

ctgactgcgc tgacaccact ggcccggggc acgctgcttg tggcgtggag agcaggcctt     3960

gctacttgcg gggggttcat gcttctctct ctgaagggga agggcagtgt gaagaagaac     4020

ctaccatttg tcatggcctt gggactcacc gctgtgaggc tggtcgaccc catcaacgtg     4080

gtgggactgc tgttgctcac aaggagtggg aagcggagct ggccccctag tgaagtactc     4140

acagctgttg gtctgatatg cgcgttggcc ggagggttcg ccaaggcgga tatagagatg     4200

gctgggccca tggccgcggt cggtctgcta attgtcagtt acgtggtctc aggaaagagt     4260

gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaagatgc ggaagtcact     4320

ggaaacagtc cccggctcga tgtggcactg gatgagagtg gtgatttctc cctagtggag     4380

gatgatggtc cccccatgag agagatcata ctcaaagtgg tcctgatgac catctgtggc     4440

atgaacccaa tagccatacc ctttgcagct ggagcgtggt acgtgtatgt gaagactgga     4500

aaaaggagtg gtgctctatg ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc     4560

acagatggag tgtacagagt aatgactcgt agactgcttg gttcaacaca agttggagtg     4620

ggagtcatgc aagagggggt cttccacact atgtggcacg tcacaaaagg atccgcgctg     4680

agaagcggtg aagggagact tgatccatac tggggagatg tcaagcagga tctggtgtca     4740

tattgtggtc cgtggaagct agacgccgcc tgggacgggc acagcgaggt gcagctcttg     4800

gccgtgcccc ccggagagag agcgaggaac atccagactc cgcccggaat atttaagaca     4860

aaggatgggg acattggagc agttgcgttg gactacccag caggaacttc aggatctcca     4920

atcctagaca agtgtgggag agtgatagga ctctatggta atggggtcgt gataaaaaat     4980

gggagttatg ttagtgccat cacccaaggg aggagggagg aagagactcc tgttgagtgc     5040

ttcgagcctt cgatgttgaa gaagaagcag ctaactgtct tagacctgca tcctggagct     5100

gggaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaac aagactccgt     5160

actgtgatct tagctccaac cagggttgtc gctgctgaaa tggaggaagc ccttagaggg     5220

cttccagtgc gttatatgac aacagcagtc aatgtcaccc attctgggac agaaattgtt     5280

gacttaatgt gccatgccac cttcacttca cgtctactac aaccaatcag agtccccaac     5340

tataatctgt atattatgga cgaggcccac ttcacagatc cctcaagtat agcagcaaga     5400

ggatacattt caacaagggt tgagatgggc gaggcggccg ccatcttcat gaccgccacc     5460

ccaccaggaa cccgtgacgc attcccggac tccaactcac caattatgga caccgaagtg     5520

gaagtcccag agagagcctg gagctcaggc tttgattggg tgacggatca ttctggaaaa     5580

acagtttggt ttgttccaag cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag     5640

gctggaaaac gggtcataca gctcagcaga aagacttttg agacagagtt cctgaaaaca     5700

aaaaatcaag agtgggactt cgtcgtgaca actgacattt cagagatggg cgccaacttt     5760

aaagctgacc gtgtcataga ttccaggaga tgcctaaagc cggtcatact tgatggcgag     5820

agagtcattc tggctggacc catgcctgtc acacatgcca gcgctgccca gaggaggggg     5880

cgcataggca ggaatcccaa caaacctgga gatgagtatc tgtatggagg tgggtgcgca     5940

gagactgatg aagaccatgc acactggctt gaagcaagaa tgcttcttga caacatttac     6000

ctccaagatg gcctcatagc ctcgctctat cgacctgagg ccgacaaagt agcagctatt     6060

gagggagagt tcaagcttag gacggagcaa aggaagacct ttgtggaact catgaaaaga     6120

ggagatcttc ctgtttggct ggcctatcag gttgcatctg ccggaataac ctacacagat     6180

agaaaatggt gctttgatgg cacgaccaac aacaccataa tggaagacag tgtgccggca     6240

gaggtgtgga ccagatacgg agagaaaaga gtgctcaaac caaggtggat ggacgccaga     6300

gtttgttcag atcatgcggc cctgaagtca ttcaaagagt ttgccgctgg gaaaagagga     6360

gyggcctttg gagtgatgga agccctggga acattgccgg gacacatgac agagagattc     6420

caggaagcca ttgacaacct cgctgtgctc atgcgggcag agactggaag caggccttac     6480

gaagccgcgg cggcccaatt gccggagacc ttagagacca tcatgctttt ggggttgctg     6540

ggaacagtct cgctgggaat ctttttcgtc ttgatgcgga ataagggcat cgggaagatg     6600

ggctttggaa tggtgactct tggggccagc gcatggctta tgtggctctc ggaaattgag     6660

ccagccagaa ttgcatgtgt cctcattgtt gtgttcctat tgctggtggt gctcatacct     6720

gagccagaaa agcaaagatc tccccaggac aaccaaatgg caatcatcat catgatagca     6780

gtgggtcttc tgggtttgat taccgccaat gaacttggat ggttggaaag aacaaagagt     6840

gacctaagcc atctaatggg aaggagagag gagggggcaa ccataggatt ctcaatggac     6900

attgacctgc ggccagcctc agcttgggct atctatgctg ctctgacaac tttcatcacc     6960

ccagccgtcc aacatgcggt gaccacttca tacaacaact actccttaat ggcgatggcc     7020

acgcaagctg gagtgttgtt tggtatgggt aaagggatgc cattctacgc atgggacttt     7080

ggagtcccgc tgctaatgat gggttgctac tcacaattaa cacccctgac cctaatagtg     7140

gccatcattt tgctcgtggc gcactacatg tacttgatcc cagggctgca ggcagcagct     7200

gcgcgtgctg cccagaagag aacggcagct ggcatcatga agaaccctgt tgtggatgga     7260

atagtggtga ctgacattga cacaatgaca attgaccacc gagtggagaa aaagatggga     7320

caggtgctac tcatagcagt agccgtctcc agcgccatac tgtcgcggac cgcctggggg     7380

tggggggagg ctggggccct gatcacagct gcaacttcca ctttgtggga aggctctccg     7440

aacaagtact ggaactcctc cacagccact tcactgtgta acatttttag gggaagttac     7500

ttggctggag cttctctaat ctacacagta acaagaaacg ctggcttggt caagagacgt     7560

gggggtggaa cgggagagac cctgggagag aaatggaagg cccgcctgaa ccagatgtcg     7620

gccctagagt tctactccta caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc     7680

cgccgcgccc tcaaggacgg tgtggcaaca ggaggccatg ctgtgtcccg aggaagtgca     7740

aagcttagat ggttggtgga gagaggatac ctgcagccct atggaaaggt cattgatctt     7800

ggatgtggca gagggggctg gagttactac gccgccacca tccgcaaagt tcaagaagtg     7860

aaaggataca caaaaggagg ccctggtcat gaagaaccca tgttggtgca aagctatggg     7920

tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt     7980

gacactttgc tgtgtgatat aggtgagtca tcatctagtc ctgaagtgga agaagcacgg     8040

acgctcagag tcctttccat ggtgggggat tggcttgaaa aaagaccagg agccttttgt     8100

ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt     8160

aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac     8220

tgggtctctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctc     8280

ttggggcgca tggacgggcc caggaggcca gtgaaatatg aggaggatgt gaatctcggc     8340

tccggcacgc gggctgtggt aagctgcgct gaagctccca acatgaagat cattggtaac     8400

cgcattgaga ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca     8460

tataggacat gggcttacca tggaagctat gaggccccta cacaagggtc agcgtcctct     8520

ctaataaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca     8580

ggaatagcca tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg     8640

gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc     8700

tggttatgga aagagctagg caaacacaaa cggccacgag tctgtaccaa agaagagttc     8760

atcaacaagg ttcgtagcaa tgcagcatta ggggcaatat ttgaagagga aaaagagtgg     8820

aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga     8880

gagcaccacc tgagaggaga gtgtcagagc tgtgtgtaca acatgatggg aaaaagagaa     8940

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggcta     9000

ggggctagat tcctggagtt cgaagccctt ggattcttga acgaggatca ctggatgggg     9060

agagagaatt caggaggtgg tgttgaaggg ctgggattac aaagactcgg atatgtccta     9120

gaagagatga gtcgcatacc aggaggaagg atgtatgctg atgacacagc tggctgggac     9180

acccgcatca gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa     9240

gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag     9300

gtcctcagac cagctgaaaa agggaagaca gttatggaca ttatttcaag acaagaccaa     9360

agggggagcg gacaagttgt cacttacgct cttaatacat tcaccaacct ggtggtgcag     9420

ctcattcgga atatggaggc tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg     9480

aggtcagaga aagtgaccaa ctggttgcag agcaacggat gggataggct caaacgaatg     9540

gcagtcagtg gagatgattg cgttgtgaaa ccaattgatg ataggtttgc acatgccctc     9600

aggttcttga atgatatggg aaaagtcagg aaggacacac aagagtggaa accctcaact     9660

ggatgggaca attgggaaga agttccgttt tgctcccacc acttcaacaa gctccatctc     9720

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgagcc     9780

cgcgtctcac caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     9840

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc     9900

atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat     9960

ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt    10020

gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat    10080

ttgggaaaaa gggaagactt gtggtgtgga tctctcatag ggcacagacc gcgcactacc    10140

tgggctgaga acatcaaaaa cacagtcaac atgatgcgca ggatcatagg tgatgaagaa    10200

aagtacatgg actacctatc cacccaagtt cgctacttgg gtgaagaagg gtccacaccc    10260

ggagtgttgt aa                                                        10272


<210>  79
<211>  10807
<212>  DNA
<213>  Zika virus isolate Zika virus/H.sapiens-tc/PHL/2012/CPC-0740, complete genome

<400>  79
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggccat gggcccatca      240

ggatggtctt ggcgatacta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagcgtcgga attgttggcc tcctcctgac cacagccatg gcagtagagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aagcgatgct ggggaggcca      540

tatcttttcc aaccacactg gggatgaata agtgttacat acaaatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgtt ggatgagggg gtagaaccag      660

atgacgtcga ttgctggtgc aacacgacat caacttgggt tgtgtatgga acctgccacc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg cagacctggt tggaatcaag agaatacaca aagcacctga      840

ttagagttga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgtcatcg      900

cttggctttt gggaagttca acgagccaaa aagtcatata tctggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtt accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcggatat ggcttcggac agccgctgcc     1200

caacacaagg tgaggcctac cttgacaagc agtcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggga gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacctga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcatgctgg ggcagacact ggaactccac     1680

attggaacaa caaagaagca ctggtagagt tcaaggacgc acatgcaaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggagccaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg cactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga tatgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccctgtaa tcactgaaag caccgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca tcactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

ggggtgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgttcgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctggtgtggt     2400

tgggtctgaa tacaaagaat ggatctattt cccttacgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtttctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggaaacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tcccctcgta gattggcagc agcagtcaag caagcctggg     2640

aagatgggat ctgtgggatc tcctctgtct caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggtttg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgtcat tggaacagct gctaagggaa     3060

aggaggctgt gcacagcgat ctaggctact ggattgagag tgagaagaac gacacatgga     3120

ggctgaagag ggcccacctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggagtagaa gaaagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caacaccaga gagggctaca ggactcaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtgggacaag aggaccatcc ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggaatgcaca atgcccccac tgtcgttccg agctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagtaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggatcact tctctcttgg agtgcttgtg attttgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agccatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catttggcgc     3780

tgatagcggc attcaaagtc agacctgcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgagagcatg ctgctggcct tggcctcgtg tcttctgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgaca acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggttcatgct cctctctctg aaggggaaag gcagtgtgaa gaagaaccta ccatttgtca     4140

tggccttggg actaactgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagtga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcggatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga aatcactgga aacagtcccc     4440

ggctcgatgt ggcactagat gagagtggtg atttctccct agtggaggat gatggtccac     4500

ccatgagaga gatcatactc aaagtggtcc tgatgaccat ctgcggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tgtatgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgcttggtt caacacaagt tggagtggga gtcatgcaag     4740

agggggtctt ccacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccgt     4860

ggaagctaga cgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaacatt taagacaaag gatggggaca     4980

ttggagcagt tgcgctggac tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactc tatggtaatg gggtcgtgat aaaaaatggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5160

tgctgaagaa gaagcagcta actgtcttag acctgcatcc tggagccggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggtcgtcgct gctgaaatgg aggaagccct tagagggctt ccagttcgtt     5340

atatgacaac agcagtcaat gtcacccatt ctgggacaga aatcgttgac ttaatgtgcc     5400

atgctacctt cacttcacgc ctactacaac caatcagagt ccccaactat aatttgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt cccggactcc aactcaccaa ttatggacac cgaggtggaa gtcccagaga     5640

gagcctggag cacaggcttt gattgggtga cggatcattc tgggaaaaca gtctggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacgaaa aatcaagagt     5820

gggacttcgt cgtgacaacc gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ttaaagccgg tcatacttga tggcgagaga gtcattttgg     5940

ctggacccat gcctgtcaca catgccagcg ctgctcagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgatgaag     6060

atcacgcaca ctggcttgaa gcaagaatgc ttcttgacaa catttacctc caagatggcc     6120

tcatagcttc gctctatcga cctgaggccg acaaagtagc agctattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttccgg     6240

tttggttggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcat gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gatacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaagagtttg ccgctgggaa aagaggagcg gcctttggag     6480

tgatagaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt tttcgtcttg atgcggaaca agggcatggg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggcttatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgtcgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc tcaggacaac caaatggcaa tcatcatcat ggtagcagtg ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaaaagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca caggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggctatc tatgctgctc tgacaacttt catcacccca gccgtccaac     7080

atgcggtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctgggg     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatggg ttgctactca caattaacac ctctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgggctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggaaaaaaa gatggggcag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggccctgat cacagctgca acttccacct tgtgggaagg ctctccgaac aagtactgga     7560

actcctccac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacgg     7680

gagagaccct gggagagaaa tggaaggccc gcctgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgtgccctca     7800

aggacggtgt ggcaacagga ggccatgctg tgtcccgagg aagtgcaaag cttagatggc     7860

tggtggagag aggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactatgcc gccaccatcc gcaaagttca ggaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccatgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcaca tggcggctga gccgtgtgac actttgctgt     8100

gtgatatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag ggtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcccag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgagagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccctacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ctgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttatggaagg     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa tgatccaagg ttctgggctc tagtggacaa ggaaagagag catcacctga     9000

gaggagagtg tcagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagattcc     9120

tagagttcga agcccttgga ttcttgaatg aggatcattg gatggggaga gagaattcag     9180

gaggtggtgt tgaaggactg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gcataccagg aggaaggatg tatgcagatg atactgctgg ctgggacacc cgcatcagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaagacagtt atggacatta tttcaagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aatacattca ccaacctggt ggtgcagctc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg ccagagaaag     9600

tgaccaactg gttgcaaagc aacggatggg ataggctcaa aagaatggca gtcagtggag     9660

atgattgcgt tgtgaaacca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaaact ccatcttaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgagcccgc gtatcaccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ttgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtat ggaacagagt gtggattgag gaaaacgacc    10140

acatggaaga caagacccca gttacaaaat ggacagacat tccctatttg ggaaaaagag    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg tactacctgg gctgagaaca    10260

tcaaaaatac agtcaacatg atgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaggttcgc tacttgggtg aagaagggtc cacacctgga gtgctgtaag    10380

caccaatctt agtgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  80
<211>  10807
<212>  DNA
<213>  Zika virus isolate Zika virus/H.sapiens-tc/THA/2014/SV0127- 14, complete genome

<400>  80
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtgggaaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcacagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aagcgatgct ggggaggcca      540

tatcttttcc aaccacactg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtagaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatccagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg cagacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagtaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcggacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaacaa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacactgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg taccgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaagg cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgttct taactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa tacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctccgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggaaacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tcccctcgta gattggcagc agtagtcaag caagcctggg     2640

aagatggtat ctgtgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcacta gagtgtgatc cagccgtcat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaac gacacatgga     3120

ggctgaggag ggcccacctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caacaccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagtaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggatcact tttcccttgg agtgcttgtg attctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgatctggct aagcttgcaa     3720

ttttgatggg tgccaccttt gcggaaatga acactggagg agatgtagct catctggcgc     3780

tggtagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgaca atatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggttcatgct cctctctctg aaggggaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agttactgga aacagtcccc     4440

ggctcgatgt ggcactagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaagtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa aactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcatgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggac tatccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactc tatggcaatg gggtcgtgat caagaatggg agttatgtca     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5160

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacgag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaagccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccatt ctgggacaga aatcgttgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcagctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt cccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

tcccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggacttcgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgatgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcat gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacgga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt tttcgtcttg atgcggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgcgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatcccc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcggc ctgggccatc tatgctgccc tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggct atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgactatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaagctg     7500

gggccctgat cacagctgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgcaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccatgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtgta aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcccag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccctacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac accagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag accgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttaaatg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gcataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcatcagca     9300

ggtttgatct ggagaatgaa gctttaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tagcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaagacagtt atggacatta tttcaagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgt tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgt gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa gtcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatc tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatctg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctataag    10380

caccaatctt agtgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagag gctgggaaac caagcccata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  81
<211>  10755
<212>  DNA
<213>  Zika virus isolate ARB7701 polyprotein gene, complete cds


<220>
<221>  misc_feature
<222>  (3606)..(3607)
<223>  n is a, c, g, or t

<400>  81
acctgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa gcgagagttt ctggtcatga aaaacccaaa      120

gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa      180

ccccttggga ggtttgaaga ggctgccagc cggacttctg ctgggtcatg gacccatcag      240

aatggttttg gcaatactag cctttttgag atttacagca atcaagccat cactgggcct      300

catcaacaga tggggttctg tggggaaaaa agaggctatg gaaataataa agaagtttaa      360

gaaagatctt gctgccatgt tgagaataat caatgctagg aaggagagga agagacgtgg      420

tgcagacacc agcatcggaa tcattggtct cctgctgact acagccatgg cagcggagat      480

taccagacgt ggaagtgcat actacatgta cttggacagg agcgatgctg ggaaggccat      540

ctcctttgct accaacttgg gagttaacaa atgccatgta cagatcatgg atctcgggca      600

catgtgtgac gccaccatga gttatgagtg ccctatgttg gacgagggag tggaaccaga      660

tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca      720

caaaaaaggt gaagcacggc gatctagaag agctgtgacg ctcccttctc actctacaag      780

gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacctgat      840

caaggttgaa aactggatat ttaggaaccc cgggtttgcg ctcgcagctg ttgccattgc      900

ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggttatga tactgctgat      960

tgccccggca tacagcatca ggtgcattgg agtcagcaat agagacttcg tggaaggcat     1020

gtcaggtggg acctgggttg atgtcgtctt ggaacatgga ggttgcgtca ccgttatggc     1080

acaggacaag ccaacagttg acatagagtt ggtcacgaca acggttagta acatggccga     1140

ggtaagatcc tactgttatg aggcatcaat atcagacatg gcttcggaca gtcgctgccc     1200

aacacaaggt gaagcctacc ttgataagca atcagacacc caatatgtgt gcaaaagaac     1260

attggtggac agaggttggg gaaatgggtg tggacttttt ggcaaaggga gcctggtgac     1320

atgtgccaag ttcacgtgtt ccaagaagat gactgggaag agcattcagc cggagaatct     1380

ggagtatcga ataatgctat cagtgcatgg ctcccagcac agcgggatga ttgttaatga     1440

cataggacat gaaactgacg aaaacagagc gaaagtcgag gtcacgccca attcaccaag     1500

agcagaagca accttgggag gctttggaag cttaggactt gattgtgaac caaggacagg     1560

cctggacttt tcagatttgt actacttgac catgaacaac aagcactggt tggtgcacaa     1620

agagtggttt catgacatcc cattgccttg gcatgctggg gcagataccg gaactccaca     1680

ctggaacaac aaggaggcat tggtagagtt caaagatgcc cacgccaaga ggcaaaccgt     1740

cgttgttcta gggagccagg aaggagccgt tcacacggct cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaaag gaaggctgtt ctccggccat ttgaaatgcc gcttaaaaat     1860

ggacaagctt agattgaagg gcgtgtcata ttccttgtgc accgcagcgt tcacatttac     1920

caaggtccca gctgaaacat tgcatggaac agttacagtg gaggtgcagt atgcagggac     1980

agatggaccc tgcaaggtcc cagcccagat ggcggtggac atgcagaccc tgaccccagt     2040

cgggaggctg ataaccgcca accctgtgat tactgaaagc actgagaatt caaagatgat     2100

gttggagctc gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa     2160

aatcacccat cactggcata ggagtggtag caccatcgga aaagcatttg aggccactgt     2220

gagaggtgcc aagagaatgg cagttctggg ggatacagcc tgggacttcg gatcagtcgg     2280

gggcgtgttc aactcattgg gcaagggtgt tcaccagatt tttggagcag ctttcaaatc     2340

actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tggtgtggtt     2400

gggtttgaac acaaagaatg gatccatctc cctcacatgc ttggccctgg ggggagtgat     2460

gatcttcctc tccacggctg tctctgctga cgtggggtgc tcggtggact tctcaaaaag     2520

agaaacgaga tgtggcacgg gggtgttcgt ctacaatgat gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcttggga     2640

agaggggatt tgtgggatct cctccgtttc aagaatggaa aacatcatgt ggaaatcagt     2700

ggaaggggag ctcaatgcta tcttagagga gaatggagtt caactgacag ttgttgtagg     2760

atctgtaaaa aaccccatgt ggagaggccc acaaagattg ccagtgcctg tgaatgagct     2820

gccccatggc tggaaagcct gggggaaatc atattttgtc agagcggcaa agaccaacaa     2880

cagttttgtt gtcgatggtg acacactgaa ggaatgtccg ctcaaacaca gagcatggaa     2940

tagtttcctt gtggaggatc atgggtttgg ggtcttccac accagtgttt ggctcaaggt     3000

tagagaagac tactcactag aatgtgaccc agccgtcata ggaacagctg ttaagggaaa     3060

ggaggccgcc cacagtgacc tgggctactg gattgaaagt gaaaagaatg acacatggag     3120

gctgaagagg gcccatctga ttgagatgaa aacatgtgag tggccaaagt ctcacactct     3180

gtggacagat ggagtagaag aaagtgatct gatcatacct aaatctttag ctggtccact     3240

cagccaccac aacactagag agggttacag aactcaagca aaagggccat ggcatagtga     3300

agagcttgaa atccggtttg aggaatgtcc aggcaccaag gttcacgtgg aggagacatg     3360

cggaactaga ggaccatctc tgagatcaac cactgcaagt ggaagggtca ttgaggaatg     3420

gtgctgtaga gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta     3480

tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac     3540

agcgggatca accgatcaca tggaccactt ctctcttgga gtgcttgtga ttctactcat     3600

ggtgcnngaa gggctgaaga agagaatgac cacaaagatc attatgagca catcaatggc     3660

agtgctggtg gccatgatcc tgggaggatt tttaatgagt gacttggcta agcttgtgat     3720

cctgatgggt gccaccttcg cagaaatgaa cactggagga gatgtggctc acttggcatt     3780

ggttgcggca tttaaagtca gaccagcctt gctggtctcc tttattttca gagctaattg     3840

gacacctcgt gagagcatgc tgctagccct ggcttcgtgt cttttgcaaa ctgcaatctc     3900

tgctctcgaa ggtgacttga tggtcctcgt caatggattt gctttggcct ggttggcaat     3960

acgagcaatg gccgtgccac gcactgacaa cattgctctg gcaatcctgg ctgctctgac     4020

accactagcc cgaggtacac tgctcgtggc atggagagcg ggcctcgcta cttgtggagg     4080

gtttatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat     4140

ggccttggga ttgactgctg tgaggatagt agaccccatt aatgtggtgg gactactgtt     4200

actcacaagg agtgggaagc ggagctggcc ccctagtgaa gtgcttacag ctgttggcct     4260

gatatgtgca ctggccggag gctttgccaa ggcagacatt gagatggctg ggcccatggc     4320

tgcagtaggc ttgctgattg tcagttatgt ggtctcagga aagagtgtgg atatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gttactggaa atagtcctcg     4440

gcttgacgtg gcactagatg agagtggtga tttctctctg gtggaggaag atggtccacc     4500

catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc     4560

catacccttt gctgcaggag cgtggtatgt gtatgtgaag actggaaaaa ggagtggtgc     4620

cctctgggat gtgcccgctc ccaaagaagt gaaaaaagga gagaccacag atggggtata     4680

cagagtgatg acccgcagac tgctgggttc aacacaggtt ggagtgggag tcatgcaaga     4740

gggagtcttc cacaccatgt ggcacgtcac aaaaggagct gcactgagga gcggtgaagg     4800

gagacttgat ccatactggg gggatgtcaa gcaggactta gtgtcatact gtgggccttg     4860

gaagttggat gcagcttggg atggacttag tgaggtgcag ctcttggcag taccccccgg     4920

agagagggcc agaaacattc agactctgcc tggaatattc aagacaaagg atggggacat     4980

cggagcagtc gctctggact accccgcagg aacttcagga tccccgatcc tagacaaatg     5040

cggaagagtg ataggacttt atggcaatgg ggttgtgatc aagaatggaa gctatgttag     5100

tgccataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat     5160

gctgaagaag aagcagctaa ctgtcctgga tctgcatcca ggagccggaa agactaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccgcacag tgattttggc     5280

tccaaccagg gttgtcgctg ctgagatgga ggaagccttg agaggacttc cggtgcgtta     5340

catgacaaca gcagttaacg tcacccactc tgggacagaa atcgttgatt tgatgtgcca     5400

tgccaccttc acctcacgcc tattacaacc catcagagtc cctaattaca atctctacat     5460

catggatgaa gcccatttca cagacccctc aagtatagct gcaagaggat acatatcaac     5520

aagggttgaa atgggcgagg cggctgccat cttcatgaca gccacgccac caggaacccg     5580

agatgcattt ccagactcca actcaccaat catggacaca gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt     5700

tccaagtgtg agaaatggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt     5760

catacaactc agcaggaaga cttttgagac agagtttcag aaaacaaaaa atcaagagtg     5820

ggactttgtc ataacaactg acatctcaga gatgggcgcg aatttcaaag ctgaccgggt     5880

catagactct aggagatgcc taaagccagt catacttgat ggtgagagag tcatcttggc     5940

tgggcccatg cctgtcacgc atgctagtgc tgctcaaagg agagggcgta taggcaggaa     6000

ccctaacaaa cctggagatg agtacatgta tggaggtgga tgtgcagaga ccgatgaaga     6060

ccatgcacac tggcttgaag caagaatgct tcttgacaac atctacctcc aggatggcct     6120

catagcctcg ctctaccggc ctgaggccga taaggtagct gccattgagg gagagttcaa     6180

gctgaggaca gagcaaagga aaacctttgt ggaacttatg aagagaggag accttcccgt     6240

ttggctagcc tatcaggttg catctgccgg aataacttac acagacagaa gatggtgctt     6300

tgatggcaca accaacaaca ccataatgga agatagtgta ccagcagaag tgtggacaaa     6360

atatggagag aagagagtgc tcaaaccaag atggatggat gcgagggtct gttccgatca     6420

tgctgccctg aagtcgttca aagaatttgc tgccgggaaa agaggagtgg ctttaggagt     6480

aatggaggcc ctgggaacat tgccaggaca catgacagag aggtttcagg aggccattga     6540

caatctcgct gtgctcatgc gagcagagac tggaagcagg ccttacaagg cagcggcagc     6600

ccaactgccg gagaccctag agaccatcat gctcttaggc ttgttgggaa cagtttcgtt     6660

ggggatcttc tttgtcttga tgcggaacaa gggcatcggg aagatgggtt ttggaatggt     6720

aactcttggg gccagtgcat ggctcatgtg gctttcggaa attgaaccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcttgttact ggtggtactc atacccgagc cagagaagca     6840

aagatctccc caggacaacc agatggcaat catcatcatg gtggcagtgg gccttctggg     6900

tttgataact gcaaacgaac ttggatggct ggaaagaaca aaaaatgaca tagctcatct     6960

aatgggaagg agagaagaag gagtaactat gggattctca atggacatcg atttgcggcc     7020

agcctccgcc tgggctatct atgccgcact gacaactctc atcaccccag ccgtccaaca     7080

cgcggtaacc acttcataca acaactactc cctaatggcg atggccacac aagctggagt     7140

gctatttggc atgggcaaag ggatgccatt ttatgcatgg gactttggag tcccgctgct     7200

aatgatgggt tgctactcac aattaacacc cctaaccttg atagtggcta tcattctgct     7260

tgtggcacac tatatgtact tgatcccagg cctacaggca gcagcagcgc gtgctgccca     7320

gaagagaaca gcagctggca tcatgaagaa tcccgttgtg gatggaatag tggtaactga     7380

cattgacaca atgacaattg acccccaagt ggagaagaag atgggacaag tgttacttat     7440

agcagtagcc atctccagtg ctgtgctgct gcggactgct tggggatggg gggaggctgg     7500

agctctgatt actgcagcaa cctccacctt gtgggaaggt tctccaaaca aatactggaa     7560

ctcctctaca gccacctcac tgtgcaacat cttcagagga agttacctgg caggcgcttc     7620

tcttatttat acagtgacaa gaaatgctgg cctagtcaag agacgtggag gtggaacggg     7680

agagactcta ggagagaagt ggaaagctcg cctgaatcag atgtcggccc tggagttcta     7740

ctcttacaaa aagtcaggca tcactgaagt gtgtagagag gaggctcgcc gcgccctcaa     7800

ggatggagtg gccacaggag gacatgctgt atcccgggga agcgcaaagc tcagatggct     7860

ggtggagaga ggatacctgc aaccccatgg aaaggttgtt gacctcggat gtggcagagg     7920

gggttggagc tattatgccg ccaccatccg gaaagtgcag gaggtgaaag gatacacaaa     7980

gggaggtccc ggtcatgaag aacccatgct ggtgcaaagc tatgggtgga acatcgttcg     8040

tctcaagagt ggagtggacg tcttccacat ggcggccgag ccgtgtgata ccttgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagag acgcgaacac tccgagtgct     8160

ctctatggtg ggggactggc ttgagaaaag accgggggcc ttctgtataa aggtgctgtg     8220

tccatacacc agcactatga tggagaccat ggagcgcctg caacgtaggt atgggggagg     8280

attagtcaga gtgccattgt ctcgcaactc cacacatgag atgtattggg tctctggagc     8340

aaaaagtaac gtcataaaaa gtgtgtccac cacaagtcag ctcctcctgg gacgcatgga     8400

tggtcccagg aggccagtga aatatgagga agatgtgaac ctcggctcgg gcacacgagc     8460

tgtggcaagc tgtgctgaag ctcccaacat gaaggtcatt ggcaagcgca ttgagagaat     8520

ccgcagtgaa catgcagaaa catggttctt tgatgaaaac catccataca ggacatgggc     8580

ctaccatggg agctacgaag cccccacaca agggtcagca tcttccctcg tgaatggggt     8640

tgttagactc ctgtcaaagc cctgggatgt agtgactgga gttacaggaa tagctatgac     8700

tgatacaaca ccatacggcc aacaaagagt cttcaaagaa aaagtggaca ccagggtgcc     8760

agatccccaa gaaggcactc gccaggcaat gaacatggtc tcttcctggc tgtggaagga     8820

gttggggaaa cgcaagcggc cacgtgtctg caccaaagaa gagttcatca acaaggtgcg     8880

cagcaatgca gcactgggag caatatttga agaggaaaaa gaatggaaga cggccgtgga     8940

ggctgtgaat gatccaaggt tttgggctct agtggacaag gaaagagaac atcacctgag     9000

aggagagtgc catagctgtg tgtacaatat gatgggaaaa agagagaaga agcaaggaga     9060

attcggaaaa gcaaaaggca gccgcgccat ctggtacatg tggttgggag ccagattctt     9120

ggagtttgaa gcccttggat tcttgaatga ggaccattgg atgggaagag aaaactcagg     9180

aggtggtgtc gaagggctag gactgcaaag acttggatac attctagaag aaatgaatcg     9240

ggcaccagga ggaaagatgt atgcagatga caccgctggc tgggacaccc gcattagtaa     9300

gtttgatctg gagaatgaag ccttaattac caaccaaatg gaggaagggc acagagctct     9360

ggcgttggct gtgattaagt acacaaaaaa caaagtggtg aaggtcctca gaccagctga     9420

aggagggaaa acagttatgg acatcatttc aagacaggac cagagaggga gtggacaagt     9480

tgtcacctat gctctcaaca catttaccaa cttagtggtg cagcttatcc ggaatatgga     9540

ggctgaggaa gtgttagaga tgcaagactt atggctgttg aggaagccag agaaagtgac     9600

cagatggttg cagtgcaatg gatgggacag actcaaacga atggcagtca gtggagatga     9660

ctgcgttgtg aagccaattg atgataggtt tgcgcatgcc ctcaggttct taaatgacat     9720

gggaaaagtt aggaaagaca cacaggaatg gaaaccctcg actggatgga gcaattggga     9780

agaagtcccg ttctgctccc accatttcaa caagctgcac ctcaaggatg gtagatccat     9840

tgtggtccct tgccgccacc aagatgaatt gattggccga gcccgtgtat caccaggggc     9900

aggatggagc attcgggaga ctgcctgtct agcaaaatca tatgcacaga tgtggcagct     9960

tctttacttc cacagaagag accttcgact gatggccaat gctatttgtt cggctgtgcc    10020

agttgactgg gtaccaaccg ggagaaccac ctggtcaatc cacggaaagg gagaatggat    10080

gactactgag gacatgctca tggtgtggaa tagagtgtgg attgaggaga acgaccatat    10140

ggaggacaag actcctgtga caaagtggac agacatcccc tatctgggaa aaagggagga    10200

cttatggtgt ggatccctta tagggcacag gccccgcacc acttgggctg agaacatcaa    10260

agacacagtc aacatggtgc gcaggatcat aggtgatgaa gaaaaataca tggactactt    10320

atccacccag gtccgctact tgggtgagga agggtccaca cctggagtgt tgtaagcacc    10380

aatttcagtg ttgtcaggcc tgctagccag ccacagtttg gggaaagctg tgcagcctgt    10440

agccccccca ggagaagctg ggaaaccaag ctcatagtca ggccgagaac gccatggcac    10500

ggaagaagcc atgctgcctg tgagcccctc agaggacact gagttaaaaa accccacgcg    10560

cttggaagcg caggatggga aaagaaggtg gcgaccttcc ccacccttta atctggggcc    10620

tgaactggag actagctgtg aatctccagc agagggacta gtggttagag gagacccccc    10680

ggaaaacgca aaacagcata ttgacgctgg gaaagaccag agactccatg agtttccacc    10740

acgctggccg ccagg                                                     10755


<210>  82
<211>  10776
<212>  DNA
<213>  Zika virus isolate ARB15076 polyprotein gene, complete cds

<400>  82
gttgttgatc tgtgtgaatc agactgcgac agttcgagtt tgaagcgaga gctaacaaca       60

gtatcaacag gtttaatttg gatttggaaa cgagagtttc tggtcatgaa aaacccaaag      120

aagaaatccg gaggattccg gattgtcaat atgctaaaac gcggagtagc ccgtgtaaac      180

cccttgggag gtttgaagag gctgccagcc ggactcctgc tgggtcatgg acccatcaga      240

atggttttgg caatactagc ctttttgaga tttacagcaa tcaagccatc actgggcctc      300

atcaacagat ggggttcagt ggggaaaaaa gaggctatgg aaataataaa gaagtttaag      360

aaagatcttg ctgccatgtt gagaataatc aatgctagga aggagaggaa gagacgtggt      420

gcagacacca gcatcggaat cattggtctc ctgctgacta cagccatggc agcagagatt      480

accagacgtg gaagtgcata ctacatgtac ttggacagga gcgatgctgg gaaggccatc      540

tcctttgcta ccaatttggg agttaacaaa tgccatgtac agatcatgga tctcgggcac      600

atgtgtgacg ccaccatgag ttatgagtgt cctatgttgg acgagggagt ggaaccagat      660

gatgtcgatt gctggtgcaa cacgacatca acttgggttg tgtacggaac ctgtcatcac      720

aaaaaaggtg aagcacggcg atctagaaga gctgtgacgc tcccttctca ctctacaagg      780

aagctgcaaa cgcggtcgca gacttggtta gaatcaagag aatacacgaa gcacttgatc      840

aaggttgaaa actggatatt caggaacccc gggtttgcgc tcgcagctgt tgccattgcc      900

tggcttttgg gaagctcgac gagccaaaaa gtcatatact tggtcatgat actgctgatt      960

gccccggcat acagcatcag gtgcattgga gtcagcaata gagacttcgt ggaaggcatg     1020

tcaggtggga cctgggttga tgtcgtcttg gaacatggag gttgcgtcac cgtaatggca     1080

caggacaagc caacagttga catagagttg gtcacgacaa cggtcagtaa catggccgag     1140

gtaagatcct actgttatga ggcatcaata tcggacatgg cttcggacag tcgctgccca     1200

acacaaggtg aagcctacct tgacaagcaa tcagacactc aatatgtatg caaaagaaca     1260

ttggtggaca gaggttgggg aaatgggtgt ggactttttg gcaaagggag cctggtgaca     1320

tgtgccaagt tcacgtgttc caagaagatg accgggaaga gcattcagcc ggagaatctg     1380

gagtatcgaa taatgctatc agtgcatggc tcccagcaca gcgggatgat tgttaatgac     1440

gaaaataggg cgaaagtcga ggtcacgccc aattcaccaa gagcagaagc aaccttggga     1500

ggctttggaa gcttaggact tgattgtgaa ccaaggacag gcctggactt ttcagatttg     1560

tactacttga ccatgaacaa taagcactgg ttagtgcaca aagagtggtt tcatgacatc     1620

ccattgccct ggcatgctgg ggcagacacc ggaactccac attggaacaa caaggaggca     1680

ttggtagagt tcaaagatgc ccacgctaag aggcaaaccg tcgttgttct agggagccag     1740

gaaggagccg ttcacacggc tcttgctgga gctctggagg ctgagatgga tggtgcaaaa     1800

ggaaggttgt tctccggcca tttgaaatgc cgcttaaaaa tggacaagct tagattgaag     1860

ggcgtgtcat attccttgtg caccgcagcg ttcacattca ccaaggtccc agctgaaaca     1920

ttgcatggaa cagttacagt ggaggtgcag tatgcaggga cagatggacc ctgcaaggtc     1980

ccagctcaga tggcggtgga catgcagacc ctgaccccag tcggaaggct gataaccgcc     2040

aaccccgtga ttactgaaag cactgagaat tcaaagatga tgttggagct cgacccacca     2100

tttggggatt cttacattgt cataggagtt ggggacaaga aaattaccca ccactggcat     2160

aggagtggta gcaccatcgg aaaagcattt gaggccactg tgagaggtgc caagagaatg     2220

gcagttctgg gggacacagc ctgggacttt ggatcagtcg ggggcgtgtt taactcattg     2280

ggcaagggca tccaccagat ttttggagca gccttcaaat cactgtttgg aggaatgtcc     2340

tggttctcac agatcctcat aggcacgctg ctggtgtggt tgggtttgaa cacaaagaat     2400

ggatccatct ccctcacatg cttggccctg gggggagtga tgatcttcct ctccacggct     2460

gtctctgctg acgtggggtg ctcggtggac ttctcaaaaa gagaaacgag atgtggcacg     2520

ggggtgttcg tctacaatga tgttgaagcc tggagggaca ggtacaagta ccatcctgac     2580

tccccccgca gattggcagc agcagtcaag caggcttggg aagagggaat ttgtgggatc     2640

tcctccgttt caagaatgga aaacatcatg tggaaatcag tggaagggga gctcaatgct     2700

atcttagagg agaatggagt tcaactgaca gttgttgtag gatctgtaaa aaaccccatg     2760

tggagaggtc cacaaagatt gccagtgcct gtgaatgagc tgccccatgg ctggaaagcc     2820

tgggggaaat catattttgt cagagcggca aagaccaaca acaggtttgt tgtcgatggt     2880

gacacactga aggaatgtcc gctcaaacac agagcatgga atagtttcct tgtggaggat     2940

catgggtttg gggtcttcca caccagtgtt tggcttaagg ttagagaaga ttactcacta     3000

gaatgtgacc cagccgtcat aggaacagct gttaagggaa aggaggccgc gcacagtgac     3060

ctaggctact ggattgaaag tgaaaagaat gacacatgga ggctgaagag ggcccacctg     3120

attgagatga aaacatgtga gtggccaaag tctcacactc tgtggacaga tggagtagaa     3180

gaaagtgatc tgatcatacc taaatcttta gctggtccac tcagccacca caacactaga     3240

gagggttaca gaactcaagc aaaagggcca tggcatagtg aagagcttga aatccggttt     3300

gaggaatgtc caggcaccaa ggttcatgtg gaggagacat gcggaactag aggaccatct     3360

ctgagatcaa ccactgcaag tggaagggtc attgaggaat ggtgctgtag agaatgcaca     3420

atgcccccac tatcgtttcg agcaaaagat ggctgctggt atggaatgga gataaggccc     3480

aggaaagaac cagagagcaa cttagtgagg tcaatggtga cagcgggatc aaccgatcac     3540

atggaccact tctctcttgg agtgcttgtg attctactca tggtgcagga agggttgaag     3600

aagagaatga ccacgaagat cattatgagc acatcaatgg cagtgctggt agccatgatc     3660

ctgggaggat tttcaatgag tgacctggct aagcttgtga tcctgatggg tgccaccttc     3720

gcagaaatga acactggagg agatgtggct cacttggcat tggttgcggc atttaaagtc     3780

agaccagcct tgctggtctc ctttattttc agagctaatt ggacacctcg tgagagcatg     3840

ctgctagccc tggcttcgtg tcttttacaa actgcaatct ctgctcttga aggtgacttg     3900

atggtcctcg tcaatggatt tgctttggcc tggttggcaa tacgagcaat ggccgtgcca     3960

cgcactgaca acattgctct agcagtcctg gctgctctga caccactagc ccgaggcaca     4020

ctgctcgtgg catggagagc gggcctcgct acttgtggag ggttcatgct cctttccctg     4080

aaggggaaag gtagtgtgaa gaagaacctg ccatttgtca tggccttggg attgaccgct     4140

gtgaggatag tagaccccat taatgtggta ggactactgt tactcacaag gagcgggaag     4200

cggagctggc cccctagtga agtgcttaca gctgttggcc tgatatgtgc actggccgga     4260

gggtttgcca aggcagacat tgagatggct gggcccatgg ctgcagtagg cttgctaatt     4320

gtcagttatg tggtctcagg aaagagtgtg gatatgtaca ttgaaagagc aggtgacatc     4380

acatgggaaa aggacgcgga agttactgga aatagtcctc ggcttgacgt ggcactagat     4440

gagagtggtg atttctctct ggtggaggaa gatggtccac ccatgagaga gatcatactc     4500

aaggtggtcc tgatggccat ctgtggcatg aacccaatag ccataccctt tgctgcagga     4560

gcgtggtatg tgtatgtgaa gactgggaaa aggagtggtg ccctctggga tgtgcccgct     4620

cccaaagaag tgaaaaaagg agagaccaca gatggagtat acagagtgat gacccgcaga     4680

ctgctgggtt caacacaggt tggagttgga gtcatgcaag agggagtctt ccacaccatg     4740

tggcacgtca caaaaggagc tgcactgagg agcggcgaag ggagacttga tccatactgg     4800

ggggatgtca agcaggactt agtgtcatac tgtgggcctt ggaagttgga tgcagcttgg     4860

gatggactta gtgaggtgca gctcttggca gtaccccccg gagagagggc cagaaacatt     4920

cagactctgc ctggaatatt caagacaaag gatggggaca tcggagcagt tgctctggac     4980

taccccgcag gaacttcagg atccccgatc ctagacaaat gcggaagagt gataggactt     5040

tatggcaatg gggttgtgat caagaatgga agctatgtta gtgccataac ccagggaaag     5100

agggaggagg agactccggt tgaatgtttc gaaccctcga tgctgaagaa gaagcagcta     5160

actgtcctgg atctgcatcc aggagccgga aagactagga gagttcttcc tgaaatagtc     5220

cgtgaagcca taaaaaagag actccgcaca gtgattttgg ctccaaccag ggttgtcgct     5280

gctgagatgg aggaagcctt gagaggactt ccggtgcgtt acatgacaac agcagttaac     5340

gtcacccact ctgggacaga aatcgttgat ttgatgtgcc atgccacctt cacttcacgc     5400

ttattacaac ccatcagagt ccctaattac aatctctaca tcatggatga agcccatttc     5460

acagacccct caagtatagc tgcaagagga tacatatcaa caagggttga aatgggcgag     5520

gcggctgcca tctttatgac agccacgcca ccaggaaccc gagatgcatt tccagactcc     5580

aactcaccaa tcatggacac agaagtggaa gtcccagaga gagcctggag ctcaggcttt     5640

gattgggtga cagaccattc tggaaaaaca gtttggtttg ttccaagtgt gagaaatgga     5700

aatgaaatcg cagcctgtct gacaaaggct ggaaagcggg tcatacaact cagcaggaag     5760

acttttgaga cagagtttca gaaaacaaaa aatcaagagt gggactttgt cataacaact     5820

gacatctcag agatgggtgc caatttcaag gctgaccggg tcatagactc taggagatgc     5880

ctaaagccag ttatacttga tggtgagaga gtcatcttgg ctgggcccat gcctgtcacg     5940

catgctagtg ctgctcaaag gagagggcgt ataggcagga accctaacaa acctggagat     6000

gagtacatgt atggaggtgg atgtgcagag accgatgaag accatgcaca ctggcttgaa     6060

gcaagaatgc ttcttgacaa catctacctc caggatggcc tcatagcttc gctctaccgg     6120

cctgaggccg acaaggtagc cgccattgag ggagagttca agctgaggac ggagcaaagg     6180

aaaacctttg tggaacttat gaagagagga gaccttcccg tttggctggc ctatcaggtt     6240

gcatctgccg gaataactta cacagacaga agatggtgct ttgatggcac aaccaacaac     6300

accataatgg aagatagtgt accagcagag gtgtggacaa aatatggaga gaagagagtg     6360

cttaaaccaa gatggatgga tgcgagggtc tgttctgatc atgctgccct gaagtcgttc     6420

aaagaatttg ctgccgggaa aagaggagcg gctttaggag taatggaggc cctgggaaca     6480

ttaccaggac acatgacaga gaggtttcag gaggccattg acaatctcgc tgtgcttatg     6540

cgagcagaga ctggaagtag gccttacaag gcagcggcag cccaactgcc ggagacccta     6600

gagaccatca tgctcctagg tttgctggga acagtttcgt tggggatctt ctttgtcttg     6660

atgcggaaca agggcatcgg gaagatgggt tttggaatgg taactcttgg ggccagtgca     6720

tggctcatgt ggctttcgga aattgagcca gccagaattg catgtgtcct cattgttgtg     6780

ttcttgttac tggtggtact catacccgag ccagagaagc aaagatctcc ccaggacaac     6840

cagatggcaa tcatcatcat ggtggcagtg ggccttctgg gtttgataac tgcaaacgaa     6900

cttggatggc tggaaagaac aaaaaatgac atagctcatc taatgggaag gagagaagaa     6960

ggagtaacta tgggattctc aatggacatc gatttgcggc cagcctccgc ctgggctatt     7020

tatgccgcac tgacaactct catcacccca gctgtccaac acgcggtaac cacttcatac     7080

aacaactact ccctaatggc gatggccaca caagctggag tgctatttgg catgggcaaa     7140

gggatgccat tttatgcatg ggactttgga gtcccgctgc taatggtggg ttgctactca     7200

caattaacac ccctaacctt gatagtggct atcattctgc ttgtggcaca ctacatgtac     7260

ttgatcccag gcctacaggc agcagcagcg cgtgctgccc agaagagaac agcagctggc     7320

atcatgaaga atcccgttgt ggatggaata gtggtaactg acattgacac aatgacaatt     7380

gacccccaag tggagaagaa gatgggacaa gtgttactca tagcagtagc catctccagt     7440

gctgtgctgc tgcgaactgc ttggggatgg ggggaggctg gagctctgat cacagcagca     7500

acctccacct tgtgggaagg ttctccaaac aaatactgga actcctctac agccacctca     7560

ctgtgcaaca tctttagagg aagttacctg gcaggcgctt ctctcattta tacagtgaca     7620

agaaatgctg gcctagtcaa gagacgtgga ggtggaacgg gagagactct aggagagaag     7680

tggaaagctc gcctgaatca gatgtcggcc ctggagttct actcttacaa aaagtcaggc     7740

atcactgaag tgtgtagaga ggaggctcgc cgcgccctca agaatggagt ggccacagga     7800

ggacatgctg tatcccgggg aagcgcaaag ctcagatggc tggtggagag aggatacctg     7860

caaccccatg gaaaggttgt tgacctcgga tgtggcagag ggggttggag ctattatgcc     7920

gccaccatcc ggaaagtgca ggaggtgaaa ggatacacaa agggaggtcc tggtcatgaa     7980

gaacccatgc tggtgcaaag ctatgggtgg aacatagttc gtctcaagag tggagtggat     8040

gtcttccaca tggcggccga gccgtgtgac accttgctgt gcgacatagg tgagtcatca     8100

tctagtcctg aagtggaaga gacgcgaaca ctcagagtgc tctctatggt gggggactgg     8160

cttgagaaaa gaccgggagc cttctgcata aaggtgctgt gcccatacac cagcactatg     8220

atggagacca tggagcgcct gcaacgtagg tatgggggag gattagtcag agtgccattg     8280

tctcgcaact ccacacatga aatgtattgg gtctctggag caaaaagtaa catcataaaa     8340

agtgtgtcca ccacaagtca gctcctcctg ggacgcatgg atggccccag gaggccagtg     8400

aaatatgagg aagatgtgaa cctcggctcg ggcacacgag ctgtggcaag ctgtgctgaa     8460

gctcccaaca tgaagatcat tggcaagcgc attgagagaa tccgcagtga acatgcagaa     8520

acatggttct ttgatgaaaa ccacccatac aggacatggg cctaccatgg gagctacgaa     8580

gcccccaccc aaggatcagc gtcttccctc gtgaatgggg ttgttagact cctgtcaaag     8640

ccctgggatg ttgtgactgg agttacagga atagctatga ctgacactac accatacggc     8700

caacaaagag tcttcaaaga aaaagtggac accagggtgc cagatcctca agaaggcact     8760

cgccagacaa tgaacatggt ttcttcctgg ctgtggaagg agctggggaa acgcaagcgg     8820

ccacgtgtct gcaccaaaga agagttcatc aacaaggtgc gcagcaatgc agcactggga     8880

gcaatatttg aagaggaaaa agaatggaag acggccgtgg aagctgtgaa tgatccaagg     8940

ttttgggccc tagtggacaa ggagagagaa catcacctga gaggagagtg ccatagctgt     9000

gtgtacaata tgatgggaaa aagagagaag aagcaaggag aattcggaaa agcaaaaggc     9060

agccgcgcca tctggtacat gtggttggga gccagattct tggagtttga agcccttgga     9120

ttcttgaatg aggaccattg gatgggaaga gaaaactcag gaggtggtgt cgaagggcta     9180

ggactgcaaa gacttggata cattctagaa gaaatgaatc gagcaccagg aggaaagatg     9240

tatgcagatg acaccgctgg ctgggatacc cgtattagta agtttgatct ggagaatgaa     9300

gccttaatta ccaaccaaat ggaggaaggg catagagctc tagcattggc tgtgattaag     9360

tacacatacc aaaacaaagt ggtgaaggtc ctcagaccag ctgaaggagg gaaaacagtt     9420

atggacatca tttcaagaca agaccagaga gggagtggac aagttgtcac ttatgctctc     9480

aacacattta ccaacttggt ggtgcagctt atccggaaca tggaggctga ggaagtgcta     9540

gagatgcaag acttatggct gctgaggaag ccagagaaag tgaccagatg gttgcagtgc     9600

aatggatggg acagactcaa acgaatggca gtcagtggag atgactgcgt tgtgaagcca     9660

attgatgata ggtttgcaca tgccctcagg ttcttgaatg acatgggaaa agttaggaaa     9720

gacacacagg aatggaaacc ctcgactgga tggagcaatt gggaagaagt cccgttctgc     9780

tcccaccatt tcaacaagct gcacctcaag gatggtagat ccattgtggt cccttgccgc     9840

caccaagatg aattgattgg ccgagcccgt gtatcaccag gggcaggatg gagcatccgg     9900

gagactgcct gtctagcaaa atcatatgca cagatgtggc agcttcttta cttccacaga     9960

agagaccttc gactgatggc caatgctatt tgttcggctg tgccagttga ctgggtgcca    10020

accgggagaa ccacctggtc aatccacgga aagggagaat ggatgactac tgaggacatg    10080

ctcatggtgt ggaatagagt gtggattgag gagaacgacc acatggagga caagactcct    10140

gtgacaaagt ggacagacat cccctatctg ggaaaaaggg aggacttatg gtgtggatcc    10200

cttatagggc acaggccccg caccacttgg gctgagaaca tcaaagacac agtcaacatg    10260

gtgcgcagga tcataggtga tgaagaaaaa tacatggact acttatccac ccaggtccgc    10320

tacttgggtg aggaagggtc cacacctgga gtgttgtaag caccaatttc agtgttgtca    10380

ggcctgctag tcagccacag tttggggaaa gctgtgcagc ctgtagcccc cccaggagac    10440

gctgggaaac caagctcata gtcaggccga gaacgccatg gcacggaaga agccatgctg    10500

cctgtgagcc cctcagagga cactgagtca aaaaacccca cgcgcttgga agcgcaggat    10560

gggaaaagaa ggtggcgacc ttccccaccc tttaatctgg ggcctgaact ggagactagc    10620

tgtgaatctc cagcagaggg actagtggtt agaggagacc ccccggaaaa cgcaaaacag    10680

catattgacg ctgggaaaga ccagagactc catgagtttc caccacgctg gccgccaggc    10740

acagatcgcc gaacagcggc ggccagtgtg gtggaa                              10776


<210>  83
<211>  10788
<212>  DNA
<213>  Zika virus isolate ARB13565 polyprotein gene, complete cds

<400>  83
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa gcgagagttt ctggtcatga aaaacccaaa      120

gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa      180

ccccttggga ggtttgaaga ggctgccagc cggacttctg ctgggtcatg gacccatcag      240

aatggttttg gcaatactag cctttttgag atttacagca atcaagccat cactgggcct      300

catcaacaga tggggttctg tggggaaaaa agaggctatg gaaataataa agaagtttaa      360

gaaagatctt gctgccatgt tgagaataat caatgctagg aaggagagga agagacgtgg      420

tgcagacacc agcatcggaa tcattggtct cctgctgact acagccatgg cagcggagat      480

taccagacgt ggaagtgcat actacatgta cttggacagg agcgatgctg ggaaggccat      540

ctcctttgct accaacttgg gagttaacaa atgccatgta cagatcatgg atctcgggca      600

catgtgtgac gccaccatga gttatgagtg ccctatgttg gacgagggag tggaaccaga      660

tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca      720

caaaaaaggt gaagcacggc gatctagaag agctgtgacg ctcccttctc actctacaag      780

gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacctgat      840

caaggttgaa aactggatat ttaggaaccc cgggtttgcg ctcgcagctg ttgccattgc      900

ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggttatga tactgctgat      960

tgccccggca tacagcatca ggtgcattgg agtcagcaat agagacttcg tggaaggcat     1020

gtcaggtggg acctgggttg atgtcgtctt ggaacatgga ggttgcgtca ccgttatggc     1080

acaggacaag ccaacagttg acatagagtt ggtcacgaca acggttagta acatggccga     1140

ggtaagatcc tactgttatg aggcatcaat atcagacatg gcttcggaca gtcgctgccc     1200

aacacaaggt gaagcctacc ttgataagca atcagacacc caatatgtgt gcaaaagaac     1260

attggtggac agaggttggg gaaatgggtg tggacttttt ggcaaaggga gcctggtgac     1320

atgtgccaag ttcacgtgtt ccaagaagat gactgggaag agcattcagc cggagaatct     1380

ggagtatcga ataatgctat cagtgcatgg ctcccagcac agcgggatga ttgttaatga     1440

cataggacat gaaactgacg aaaacagagc gaaagtcgag gtcacgccca attcaccaag     1500

agcagaagca accttgggag gctttggaag cttaggactt gattgtgaac caaggacagg     1560

cctggacttt tcagatttgt actacttgac catgaacaac aagcactggt tggtgcacaa     1620

agagtggttt catgacatcc cattgccttg gcatgctggg gcagataccg gaactccaca     1680

ctggaacaac aaggaggcat tggtagagtt caaagatgcc cacgccaaga ggcaaaccgt     1740

cgttgttcta gggagccagg aaggagccgt tcacacggct cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaaag gaaggctgtt ctccggccat ttgaaatgcc gcttaaaaat     1860

ggacaagctt agattgaagg gcgtgtcata ttccttgtgc accgcagcgt tcacatttac     1920

caaggtccca gctgaaacat tgcatggaac agttacagtg gaggtgcagt atgcagggac     1980

agatggaccc tgcaaggtcc cagcccagat ggcggtggac atgcagaccc tgaccccagt     2040

cgggaggctg ataaccgcca accctgtgat tactgaaagc actgagaatt caaagatgat     2100

gttggagctc gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa     2160

aatcacccat cactggcata ggagtggtag caccatcgga aaagcatttg aggccactgt     2220

gagaggtgcc aagagaatgg cagttctggg ggatacagcc tgggacttcg gatcagtcgg     2280

gggcgtgttc aactcattgg gcaagggtgt tcaccagatt tttggagcag ctttcaaatc     2340

actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tggtgtggtt     2400

gggtttgaac acaaagaatg gatccatctc cctcacatgc ttggccctgg ggggagtgat     2460

gatcttcctc tccacggctg tctctgctga cgtggggtgc tcggtggact tctcaaaaag     2520

agaaacgaga tgtggcacgg gggtgttcgt ctacaatgat gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcttggga     2640

agaggggatt tgtgggatct cctccgtttc aagaatggaa aacatcatgt ggaaatcagt     2700

ggaaggggag ctcaatgcta tcttagagga gaatggagtt caactgacag ttgttgtagg     2760

atctgtaaaa aaccccatgt ggagaggccc acaaagattg ccagtgcctg tgaatgagct     2820

gccccatggc tggaaagcct gggggaaatc atattttgtc agagcggcaa agaccaacaa     2880

cagttttgtt gtcgatggtg acacactgaa ggaatgtccg ctcaaacaca gagcatggaa     2940

tagtttcctt gtggaggatc atgggtttgg ggtcttccac accagtgttt ggctcaaggt     3000

tagagaagac tactcactag aatgtgaccc agccgtcata ggaacagctg ttaagggaaa     3060

ggaggccgcc cacagtgacc tgggctactg gattgaaagt gaaaagaatg acacatggag     3120

gctgaagagg gcccatctga ttgagatgaa aacatgtgag tggccaaagt ctcacactct     3180

gtggacagat ggagtagaag aaagtgatct gatcatacct aaatctttag ctggtccact     3240

cagccaccac aacactagag agggttacag aactcaagca aaagggccat ggcatagtga     3300

agagcttgaa atccggtttg aggaatgtcc aggcaccaag gttcacgtgg aggagacatg     3360

cggaactaga ggaccatctc tgagatcaac cactgcaagt ggaagggtca ttgaggaatg     3420

gtgctgtaga gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta     3480

tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac     3540

agcgggatca accgatcaca tggaccactt ctctcttgga gtgcttgtga ttctactcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc attatgagca catcaatggc     3660

agtgctggtg gccatgatcc tgggaggatt tttaatgagt gacttggcta agcttgtgat     3720

cctgatgggt gccaccttcg cagaaatgaa cactggagga gatgtggctc acttggcatt     3780

ggttgcggca tttaaagtca gaccagcctt gctggtctcc tttattttca gagctaattg     3840

gacacctcgt gagagcatgc tgctagccct ggcttcgtgt cttttgcaaa ctgcaatctc     3900

tgctctcgaa ggtgacttga tggtcctcgt caatggattt gctttggcct ggttggcaat     3960

acgagcaatg gccgtgccac gcactgacaa cattgctctg gcaatcctgg ctgctctgac     4020

accactagcc cgaggtacac tgctcgtggc atggagagcg ggcctcgcta cttgtggagg     4080

gtttatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat     4140

ggccttggga ttgactgctg tgaggatagt agaccccatt aatgtggtgg gactactgtt     4200

actcacaagg agtgggaagc ggagctggcc ccctagtgaa gtgcttacag ctgttggcct     4260

gatatgtgca ctggccggag gctttgccaa ggcagacatt gagatggctg ggcccatggc     4320

tgcagtaggc ttgctgattg tcagttatgt ggtctcagga aagagtgtgg atatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gttactggaa atagtcctcg     4440

gcttgacgtg gcactagatg agagtggtga tttctctctg gtggaggaag atggtccacc     4500

catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc     4560

catacccttt gctgcaggag cgtggtatgt gtatgtgaag actggaaaaa ggagtggtgc     4620

cctctgggat gtgcccgctc ccaaagaagt gaaaaaagga gagaccacag atggggtata     4680

cagagtgatg acccgcagac tgctgggttc aacacaggtt ggagtgggag tcatgcaaga     4740

gggagtcttc cacaccatgt ggcacgtcac aaaaggagct gcactgagga gcggtgaagg     4800

gagacttgat ccatactggg gggatgtcaa gcaggactta gtgtcatact gtgggccttg     4860

gaagttggat gcagcttggg atggacttag tgaggtgcag ctcttggcag taccccccgg     4920

agagagggcc agaaacattc agactctgcc tggaatattc aagacaaagg atggggacat     4980

cggagcagtc gctctggact accccgcagg aacttcagga tccccgatcc tagacaaatg     5040

cggaagagtg ataggacttt atggcaatgg ggttgtgatc aagaatggaa gctatgttag     5100

tgccataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat     5160

gctgaagaag aagcagctaa ctgtcctgga tctgcatcca ggagccggaa agactaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccgcacag tgattttggc     5280

tccaaccagg gttgtcgctg ctgagatgga ggaagccttg agaggacttc cggtgcgtta     5340

catgacaaca gcagttaacg tcacccactc tgggacagaa atcgttgatt tgatgtgcca     5400

tgccaccttc acctcacgcc tattacaacc catcagagtc cctaattaca atctctacat     5460

catggatgaa gcccatttca cagacccctc aagtatagct gcaagaggat acatatcaac     5520

aagggttgaa atgggcgagg cggctgccat cttcatgaca gccacgccac caggaacccg     5580

agatgcattt ccagactcca actcaccaat catggacaca gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt     5700

tccaagtgtg agaaatggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt     5760

catacaactc agcaggaaga cttttgagac agagtttcag aaaacaaaaa atcaagagtg     5820

ggactttgtc ataacaactg acatctcaga gatgggcgcg aatttcaaag ctgaccgggt     5880

catagactct aggagatgcc taaagccagt catacttgat ggtgagagag tcatcttggc     5940

tgggcccatg cctgtcacgc atgctagtgc tgctcaaagg agagggcgta taggcaggaa     6000

ccctaacaaa cctggagatg agtacatgta tggaggtgga tgtgcagaga ccgatgaaga     6060

ccatgcacac tggcttgaag caagaatgct tcttgacaac atctacctcc aggatggcct     6120

catagcctcg ctctaccggc ctgaggccga taaggtagct gccattgagg gagagttcaa     6180

gctgaggaca gagcaaagga aaacctttgt ggaacttatg aagagaggag accttcccgt     6240

ttggctagcc tatcaggttg catctgccgg aataacttac acagacagaa gatggtgctt     6300

tgatggcaca accaacaaca ccataatgga agatagtgta ccagcagaag tgtggacaaa     6360

atatggagag aagagagtgc tcaaaccaag atggatggat gcgagggtct gttccgatca     6420

tgctgccctg aagtcgttca aagaatttgc tgccgggaaa agaggagtgg ctttaggagt     6480

aatggaggcc ctgggaacat tgccaggaca catgacagag aggtttcagg aggccattga     6540

caatctcgct gtgctcatgc gagcagagac tggaagcagg ccttacaagg cagcggcagc     6600

ccaactgccg gagaccctag agaccatcat gctcttaggc ttgttgggaa cagtttcgtt     6660

ggggatcttc tttgtcttga tgcggaacaa gggcatcggg aagatgggtt ttggaatggt     6720

aactcttggg gccagtgcat ggctcatgtg gctttcggaa attgaaccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcttgttact ggtggtactc atacccgagc cagagaagca     6840

aagatctccc caggacaacc agatggcaat catcatcatg gtggcagtgg gccttctggg     6900

tttgataact gcaaacgaac ttggatggct ggaaagaaca aaaaatgaca tagctcatct     6960

aatgggaagg agagaagaag gagtaactat gggattctca atggacatcg atttgcggcc     7020

agcctccgcc tgggctatct atgccgcact gacaactctc atcaccccag ccgtccaaca     7080

cgcggtaacc acttcataca acaactactc cctaatggcg atggccacac aagctggagt     7140

gctatttggc atgggcaaag ggatgccatt ttatgcatgg gactttggag tcccgctgct     7200

aatgatgggt tgctactcac aattaacacc cctaaccttg atagtggcta tcattctgct     7260

tgtggcacac tatatgtact tgatcccagg cctacaggca gcagcagcgc gtgctgccca     7320

gaagagaaca gcagctggca tcatgaagaa tcccgttgtg gatggaatag tggtaactga     7380

cattgacaca atgacaattg acccccaagt ggagaagaag atgggacaag tgttacttat     7440

agcagtagcc atctccagtg ctgtgctgct gcggactgct tggggatggg gggaggctgg     7500

agctctgatt actgcagcaa cctccacctt gtgggaaggt tctccaaaca aatactggaa     7560

ctcctctaca gccacctcac tgtgcaacat cttcagagga agttacctgg caggcgcttc     7620

tcttatttat acagtgacaa gaaatgctgg cctagtcaag agacgtggag gtggaacggg     7680

agagactcta ggagagaagt ggaaagctcg cctgaatcag atgtcggccc tggagttcta     7740

ctcttacaaa aagtcaggca tcactgaagt gtgtagagag gaggctcgcc gcgccctcaa     7800

ggatggagtg gccacaggag gacatgctgt atcccgggga agcgcaaagc tcagatggct     7860

ggtggagaga ggatacctgc aaccccatgg aaaggttgtt gacctcggat gtggcagagg     7920

gggttggagc tattatgccg ccaccatccg gaaagtgcag gaggtgaaag gatacacaaa     7980

gggaggtccc ggtcatgaag aacccatgct ggtgcaaagc tatgggtgga acatcgttcg     8040

tctcaagagt ggagtggacg tcttccacat ggcggccgag ccgtgtgata ccttgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagag acgcgaacac tccgagtgct     8160

ctctatggtg ggggactggc ttgagaaaag accgggggcc ttctgtataa aggtgctgtg     8220

tccatacacc agcactatga tggagaccat ggagcgcctg caacgtaggt atgggggagg     8280

attagtcaga gtgccattgt ctcgcaactc cacacatgag atgtattggg tctctggagc     8340

aaaaagtaac gtcataaaaa gtgtgtccac cacaagtcag ctcctcctgg gacgcatgga     8400

tggtcccagg aggccagtga aatatgagga agatgtgaac ctcggctcgg gcacacgagc     8460

tgtggcaagc tgtgctgaag ctcccaacat gaaggtcatt ggcaagcgca ttgagagaat     8520

ccgcagtgaa catgcagaaa catggttctt tgatgaaaac catccataca ggacatgggc     8580

ctaccatggg agctacgaag cccccacaca agggtcagca tcttccctcg tgaatggggt     8640

tgttagactc ctgtcaaagc cctgggatgt agtgactgga gttacaggaa tagctatgac     8700

tgatacaaca ccatacggcc aacaaagagt cttcaaagaa aaagtggaca ccagggtgcc     8760

agatccccaa gaaggcactc gccaggcaat gaacatggtc tcttcctggc tgtggaagga     8820

gttggggaaa cgcaagcggc cacgtgtctg caccaaagaa gagttcatca acaaggtgcg     8880

cagcaatgca gcactgggag caatatttga agaggaaaaa gaatggaaga cggccgtgga     8940

ggctgtgaat gatccaaggt tttgggctct agtggacaag gaaagagaac atcacctgag     9000

aggagagtgt catagctgtg tgtacaacat gatgggaaaa agagagaaga agcaaggaga     9060

attcggaaaa gcaaaaggca gccgcgccat ctggtacatg tggttgggag ccagattctt     9120

ggagtttgaa gcccttggat tcttgaatga ggaccattgg atgggaagag aaaactcagg     9180

aggtggtgtc gaagggctag gactgcaaag acttggatac attctagaag aaatgaatcg     9240

ggcaccagga ggaaagatgt atgcagatga caccgctggc tgggacaccc gcattagtaa     9300

gtttgatctg gagaatgaag ccttaattac caaccaaatg gaggaagggc acagagctct     9360

ggcgttggct gtgattaagt acacaaaaaa caaagtggtg aaggtcctca gaccagctga     9420

aggagggaaa acagttatgg acatcatttc aagacaggac cagagaggga gtggacaagt     9480

tgtcacctat gctctcaaca catttaccaa cttagtggtg cagcttatcc ggaatatgga     9540

ggctgaggaa gtgttagaga tgcaagactt atggctgttg aggaagccag agaaagtgac     9600

cagatggttg cagtgcaatg gatgggacag actcaaacga atggcagtca gtggagatga     9660

ctgcgttgtg aagccaattg atgataggtt tgcgcatgcc ctcaggttct taaatgacat     9720

gggaaaagtt aggaaagaca cacaggaatg gaaaccctcg actggatgga gcaattggga     9780

agaagtcccg ttctgctccc accatttcaa caagctgcac ctcaaggatg gtagatccat     9840

tgtggtccct tgccgccacc aagatgaatt gattggccga gcccgtgtat caccaggggc     9900

aggatggagc attcgggaga ctgcctgtct agcaaaatca tatgcacaga tgtggcagct     9960

tctttacttc cacagaagag accttcgact gatggccaat gctatttgtt cggctgtgcc    10020

agttgactgg gtaccaaccg ggagaaccac ctggtcaatc cacggaaagg gagaatggat    10080

gactactgag gacatgctca tggtgtggaa tagagtgtgg attgaggaga acgaccatat    10140

ggaggacaag actcctgtga caaagtggac agacatcccc tatctgggaa aaagggagga    10200

cttatggtgt ggatccctta tagggcacag gccccgcacc acttgggctg agaacatcaa    10260

agacacagtc aacatggtgc gcaggatcat aggtgatgaa gaaaaataca tggactactt    10320

atccacccag gtccgctact tgggtgagga agggtccaca cctggagtgt tgtaagcacc    10380

aatttcagtg ttgtcaggcc tgctagccag ccacagtttg gggaaagctg tgcagcctgt    10440

agccccccca ggagaagctg ggaaaccaag ctcatagtca ggccgagaac gccatggcac    10500

ggaagaagcc atgctgcctg tgagcccctc agaggacact gagttaaaaa accccacgcg    10560

cttggaagcg caggatggga aaagaaggtg gcgaccttcc ccacccttta atctggggcc    10620

tgaactggag actagctgtg aatctccagc agagggacta gtggttagag gagacccccc    10680

ggaaaacgca aaacagcata ttgacgctgg gaaagaccag agactccatg agtttccacc    10740

acgctggccg ccaggcacag atcgccgaac agcggcggcc agtgtggg                 10788


<210>  84
<211>  10254
<212>  DNA
<213>  Zika virus strain MR 766 polyprotein gene, complete cds

<400>  84
atgaaaaacc caaagaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg taaacccctt gggaggtttg aagaggctgc cagccggact tctgctgggt      120

catggaccca tcagaatggt tttggcgata ttagcctttt tgagattcac agcaatcaag      180

ccatcactgg gcctcatcaa cagatggggt accgtgggga aaaaagaggc tatggaaata      240

ataaaaaaat ttaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaggag      300

aggaagagac gtggcgcaga caccagcatc ggaatcgttg gcctcctgtt gactacagcc      360

atggcagcag agatcactag acgtgggagt gcatactaca tgtacttgga taggagcgat      420

gcagggaagg ccatttcttt cgctaccaca ttgggggtga acaaatgcca tgtgcagatc      480

atggacctcg ggcacatgtg tgacgccacc atgagctatg aatgccctat gctggacgag      540

ggggtggaac cagatgacgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac      600

ggaacctgtc atcataaaaa aggtgaagca cggcgatcta gaagagccgt cacgctccca      660

tctcactcca caaggaaatt gcaaacgcgg tcgcagactt ggctagaatc aagagaatac      720

acaaagcacc tgatcaaggt tgaaaattgg atattcagga accctggttt tacgctagtg      780

gctgtcgcca tcgcctggct tttgggaagc tcgacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagt atcaggtgca taggagtcag caatagagac      900

ttcgtggagg gcatgtcagg tgggacctgg gttgacgttg tcctggaaca tggaggctgc      960

gtcaccgtga tggcacagga caagccaaca gttgacatag agctggtcac aacaacggtt     1020

agtaacatgg ccgaggtgag atcctattgt tacgaggcat caatatcgga catggcttcg     1080

gacagtcgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtttgcaaaa gaacattggt ggacagaggt tggggaaatg ggtgtggact ctttggcaaa     1200

gggagtttgg tgacatgtgc taagttcacg tgctccaaga agatgactgg gaagagcatt     1260

cagccggaga acctggagta tcggataatg ctatcagtgc atggctccca gcacagtggg     1320

atgattgtta atgatgaaaa cagagcgaag gtcgaggtta cgcccaattc accaagagca     1380

gaagcaaccc tgggaggctt tggaagctta ggacttgatt gtgaaccaag gacaggcctt     1440

gacttttcag atctgtatta cctaaccatg aataacaagc attggttggt gcacaaagag     1500

tggtttcatg acatcccatt gccctggcat gctggggcag acactggaac tccacattgg     1560

aacaacaagg aggcattagt ggaattcaag gacgcccacg ccaagaggca aaccgtcgtg     1620

gttttgggga gccaggaagg agccgtccac acggctcttg ctggagctct agaggctgag     1680

atggatggtg caaagggaag gctattctct ggccacttga aatgtcgctt aaaaatggac     1740

aagcttagat tgaagggcgt gtcatattcc ttgtgcaccg cggcattcac attcaccaag     1800

gtcccggctg aaacactaca tggaacagtc acagtggagg tgcagtatgc agggacagat     1860

ggaccctgca aggtcccagc ccagatggcg gtggacatgc agaccttgac cccagtcgga     1920

aggctgataa ccgccaaccc cgtgattact gaaagcactg agaattcaaa gatgatgttg     1980

gagctcgacc caccatttgg ggattcttac attgtcatag gagttgggga taagaaaatc     2040

acccatcact ggcataggag tggcagcacc attggaaaag catttgaagc cactgtgaga     2100

ggcgctaaga gaatggcagt cctgggggac acagcttggg actttggatc agtcggaggt     2160

gtgtttaact cattgggcaa gggcattcat cagatttttg gagcagcttt caaatcactg     2220

tttggaggaa tgtcctggtt ctcacagatc ctcataggca ctctgctggt gtggttaggt     2280

ctgaacacaa agaatgggtc tatctccctc acatgcttag ccctgggggg agtgatgatc     2340

ttcctctcca cggctgtttc tgctgacgtg gggtgctcgg tggacttctc aaaaaaagaa     2400

acgagatgtg gcacgggggt gttcgtctac aatgacgttg aagcctggag ggaccggtac     2460

aagtaccatc ctgactcccc tcgtagactg gcagcagccg ttaagcaagc ttgggaagag     2520

gggatttgtg ggatctcctc tgtttctaga atggaaaaca taatgtggaa atcagtggaa     2580

ggagagctca atgcaatcct agaggagaat ggagtccaac tgacagttgt tgtgggatct     2640

gtaaaaaacc ccatgtggag aggcccacaa agattgccag tgcctgtgaa tgagctgccc     2700

catggctgga aagcctgggg gaaatcgtac tttgttaggg cggcaaagac caacaacagt     2760

tttgttgtcg acggtgacac attgaaggaa tgtccgctca agcacagagc atggaacagc     2820

ttcctcgtgg aggatcacgg gtttggggtc ttccacacca gtgtttggct taaggttaga     2880

gaagattact cactggagtg tgacccagcc gtcataggaa cagctgttaa gggaaaggag     2940

gccgcgcaca gtgatctagg ctattggatt gaaagtgaaa agaatgacac atggaggctg     3000

aagagggctc atttgattga gatgaaaaca tgtgagtggc caaagtctca cacactgtgg     3060

acagatggag tggaagaaag tgatctgatc atacccaagt ctttagctgg tccactcagc     3120

caccacaaca ccagagaggg ttacagaact caagtgaaag ggccatggca tagtgaggag     3180

cttgaaatcc gatttgagga atgtccaggt accaaggttc atgtggagga gacatgcgga     3240

acgagaggac catctctgag atcaaccact gcaagcggaa gggtcattga ggaatggtgc     3300

tgtagggaat gcacaatgcc cccactatcg ttccgagcaa aagatggctg ctggtatgga     3360

atggagataa ggcctaggaa agaaccagag agcaacttag tgaggtcaat ggtgacagcg     3420

ggatcaaccg atcatatgga tcatttttct cttggagtgc ttgtgattct actcatggtg     3480

caggaagggt tgaagaagag aatgaccaca aagatcatca tgagcacatc aatggcagtg     3540

ctggtggcca tgatcttggg aggattctca atgagtgacc tggctaagct tgtgatcctg     3600

atgggggcca ctttcgcaga aatgaacact ggaggagacg tagctcactt ggcattagta     3660

gcggcattta aagtcagacc agccttgctg gtctcattta tcttcagagc caactggaca     3720

cctcgtgaga gcatgctgct agccttggct tcgtgtcttc tgcaaactgc gatctccgct     3780

cttgaaggcg acttgatggt cctcgttaat ggatttgctt tggcctggtt ggcaatacgt     3840

gcaatggccg tgccacgcac tgacaacatc gctctagcaa ttctggctgc tctaacacca     3900

ctagcccgag gcacactgct cgtggcatgg agagcgggcc tcgccacttg tggagggttc     3960

atgctcctct ccctgaaagg gaaaggtagt gtgaagaaga acctgccatt cgtcgcggcc     4020

ttgggattga ccgctgtgag aatagtggac cccattaatg tggtgggact actgttactc     4080

acaaggagtg ggaagcggag ctggccccct agtgaagtgc tcactgctgt cggcctgata     4140

tgtgcattgg ccggagggtt tgccaaggca gacatagaga tggctgggcc catggcggca     4200

gtgggcctgc taattgtcag ttatgtggtc tcgggaaaga gtgtagatat gtacattgaa     4260

agagcaggtg acatcacatg ggagaaagac gcggaagtca ctggaaacag tcctcggctt     4320

gacgtggcac tagatgagag tggtgatttc tctctggtgg aggaagatgg tccacccatg     4380

agagagatca tacttaaggt ggtcttgatg gccatctgtg gcatgaaccc aatagccata     4440

ccttttgctg caggagcgtg gtatgtgtat gtgaagactg ggaaaaggag tggtgccctc     4500

tgggacgtgc ctgctccgaa agaagtgaaa aaaggagaga ccacagatgg agtgtacaga     4560

gtgatgactc gcagactgct gggttcaaca caagttggag tgggagtcat gcaggaggga     4620

gtcttccaca ccatgtggca cgtcacaaaa ggggccgcat tgaggagcgg tgaagggaga     4680

cttgatccat actgggggga tgtcaagcag gacttggtgt catattgtgg gccttggaag     4740

ctggacgcag cttgggacgg agttagtgag gtgcagcttc tggccgtacc ccctggagag     4800

agagccagaa acattcagac tctgcctgga atatttaaga caaaggatgg ggacatcgga     4860

gcagttgctt tggactatcc tgcaggaacc tcaggatctc cgatcctaga caaatgcggg     4920

agagtgatag gactctatgg caatggggtt gtgatcaaga acggaagcta tgttagtgct     4980

ataacccagg gaaagaggga ggaggagact ccggttgagt gttttgaacc ctcgatgctg     5040

aagaagaagc agctaactgt cctggacctg catccagggg ctgggaaaac caggagagtt     5100

cttcctgaaa tagtccgtga agctataaag aagagactcc gcacggtgat cttggcacca     5160

accagggtcg tcgctgctga gatggaggaa gccctgagag gacttccggt gcgttacatg     5220

acaacagcag tcaaggtcac ccattctggg acagaaatcg ttgatttgat gtgccatgcc     5280

accttcactt cacgcctact acaacccatt agagtcccta attacaacct ctacatcatg     5340

gatgaagccc atttcacaga cccctcaagc atagctgcaa gaggatatat atcaacaagg     5400

gttgagatgg gcgaggcagc agccatcttt atgactgcca caccaccagg aacccgcgat     5460

gcgtttccag attccaactc accaatcatg gacacagaag tggaagtccc agagagagcc     5520

tggagctcag gctttgattg ggtgacggac cattctggga aaacagtttg gttcgttcca     5580

agcgtgagga atggaaatga aatcgcagcc tgtctgacaa aggctggaaa gcgggttata     5640

cagcttagta ggaaaacttt tgagacagag tttcagaaaa caaaaaatca agagtgggac     5700

tttgtcataa caactgacat ctcagagatg ggtgccaact tcaaggctga ccgggttata     5760

gattccagga gatgcctaaa gccagttata cttgatggtg agagagtcat cttggctggg     5820

cccatgcctg tcacgcatgc tagcgctgct cagaggagag gacgtatagg caggaacccc     5880

aacaagcctg gagatgagta catgtatgga ggtgggtgtg cggagactga tgaagaccat     5940

gcacattggc ttgaagcaag aatgcttctt gacaacattt acctccagga tggcctcata     6000

gcctcgctct atcgacctga ggccgacaag gtagccgcca ttgagggaga gtttaagctg     6060

aggacagagc aaaggaagac ctttgtggaa ctcatgaaga gaggagatct tcccgtttgg     6120

ttggcctacc aggttgcatc tgccggaata acttatacag acagaagatg gtgttttgat     6180

ggcacaacca acaacaccat aatggaagac agtgtaccag cagaggtgtg gaccaagtat     6240

ggagagaaga gagtgctcaa accaagatgg atggacgcca gggtctgctc agatcatgcg     6300

gccctgaagt cgttcaaaga attcgccgct gggaaaagag gagcggcttt gggagtaatg     6360

gaggccctgg gaacattacc aggacacatg acagagaggt ttcaggaagc cattgataac     6420

ctcgctgtgc tcatgcgagc agagactgga agcaggccct acaaggcagc ggcagcccaa     6480

ttgccggaga ccctagagac catcatgctt ttaggcctgc tgggaacagt atcgctgggg     6540

atcttttttg tcttgatgag gaacaagggc atcgggaaga tgggctttga aatggtaacc     6600

cttggggcca gcgcatggct catgtggctc tcagaaatcg aaccagccag aattgcatgt     6660

gtccttattg ttgtgttttt attactggtg gtgctaatac cagagccaga gaagcaaaga     6720

tccccccagg acaatcagat ggcaatcatt attatggtgg cagtgggcct tttggggttg     6780

ataactgcaa atgaacttgg atggctggag agaacaaaaa atgacatagc tcatctgatg     6840

ggaaagagag aagagggaac aaccgtggga ttctcaatgg acatcgatct gcgaccagcc     6900

tccgcatggg ctatttatgc cgcattgaca accctcatca ccccagccgt ccagcacgcg     6960

gtaactacct cgtacaacaa ctactcctta atggcgatgg ccacacaagc tggagtgctg     7020

tttggcatgg gcaaagggat gccattttat gcatgggact taggagtccc gttgctaatg     7080

atgggctgct actcacaact aacacccctg accctgatag tagccatcat tttgcttgtg     7140

gcacattaca tgtacttgat cccaggccta caggcagcag cagcacgcgc tgcccagaag     7200

agaacagcag ccggcatcat gaagaatccc gttgtggatg gaatagtggt aactgacatt     7260

gacacaatga caattgaccc ccaagtggag aagaagatgg gacaagtgct acttatagca     7320

gtggctgtct ccagtgctgt gttgctgcgg accgcttggg gatgggggga ggctggagct     7380

ttgatcacag cagcaacttc caccctgtgg gaaggctccc caaacaaata ctggaactcc     7440

tccacagcca cctcactgtg caacatcttc agaggaagtt acttggcagg agcttccctt     7500

atttacacag tgacaagaaa tgccggcctg gttaagagac gtggaggtgg aacgggagaa     7560

actctgggag agaagtggaa agcccgcctg aatcagatgt cggccttgga gttctactct     7620

tacaaaaagt caggcatcac tgaagtatgt agagaggagg ctcgccgcgc cctcaaggat     7680

ggagtggcca caggaggaca tgctgtatcc cgaggaagcg caaaactcag atggttggtg     7740

gagagaggat atctgcagcc ctatggaaag gttgttgatc tcggatgcgg cagagggggc     7800

tggagttatt atgccgccac catccgcaaa gtgcaggagg tgagaggata cacaaaggga     7860

ggtcccggtc atgaagagcc catgctggtg caaagctatg ggtggaacat aattcgtctc     7920

aagagtggag tggacgtctt ccacatggcg gctgagtcgt gtgacacttt gctgtgtgac     7980

ataggtgagt catcatccag tcctgaagtg gaggagacgc gaacactcag agtgctctcc     8040

atggtggggg actggcttga gaagagacca ggggccttct gcataaaggt gttatgccca     8100

tacaccagca ccatgatgga gaccatggag cgactgcaac gtaggtatgg gggaggacta     8160

gtcagagtgc cactgtcccg caattctaca catgagatgt attgggtctc tggagcaaaa     8220

agtaacatca taaaaagtgt gtccaccaca agtcagctcc tcctgggacg catggatggg     8280

cccaggaggc cagtgaagta tgaggaggat gtgaacctcg gctcaggcac acgagctgtg     8340

gcaagctgtg ctgaggctcc caacatgaag gtcattggta ggcgcattga gagaatccgt     8400

agtgaacatg cagaaacatg gttctttgat gaaaaccatc catacaggac atgggcctac     8460

cacgggagct acgaagcccc cacgcaaggg tcagcatctt ccctcgtgaa tggggttgtt     8520

agactcctgt caaagccctg ggatgtggtg actggagtta caggaatagc tatgactgac     8580

accacaccgt acggccaaca aagagtcttc aaagaaaaag tggacaccag ggtgccagac     8640

cctcaagaag gtactcgcca ggtaatgaac atggtcgctt cctggctgtg gaaggagctg     8700

ggaaaacgta agcggccacg tgtctgcacc aaagaagagt tcatcaacaa ggtgcgcagc     8760

aatgcagcac tgggagcaat atttgaagag gaaaaagaat ggaagacggc tgtggaagct     8820

gtgaatgatc caaggttttg ggccctagtg gataaggaaa gagaacacca cctgagagga     8880

gagtgccata gttgtgtgta caacatgatg ggaaaaagag aaaagaagca aggggaattc     8940

gggaaagcaa aaggcagtcg cgccatctgg tacatgtggt tgggagccag attcttggag     9000

tttgaagccc ttggattctt gaacgaggac cattggatgg gaagagaaaa ctcaggaggt     9060

ggtgtcgaag ggttgggact gcaaagactt ggatacgttc tagaagaaat gagccgggca     9120

ccaggaggaa agatgtatgc agatgacacc gctggctggg acacccgcat tagcaagttt     9180

gatttggaga atgaagcctt gattactaac caaatggatg aagggcacag aactctggcg     9240

ttggccgtga ttaagtacac ataccaaaac aaagtggtga aggtcctcag accagctgaa     9300

ggaggaaaaa cagtcatgga catcatttca agacaagacc agagggggag cggacaagtt     9360

gtcacttatg ctctcaacac atttaccaac ttggtggtgc agctcatccg gaacatggag     9420

gctgaggaag tgttagagat gcaagactta tggctgttga ggaagccaga gaaagtaacc     9480

agatggctgc agagtagcgg atgggacaga ctcaaacgaa tggcagtcag tggtgatgac     9540

tgtgttgtaa agccaattga tgacaggttt gcacacgccc tcaggttctt gaatgatatg     9600

gggaaagtta ggaaagacac acaggaatgg aaaccctcaa ctggatggag caactgggaa     9660

gaagtcccgt tctgctccca ccactttaac aagctgcacc tcaaagacgg gagatccatt     9720

gtggtccctt gccgccacca agatgaactg attggccggg ctcgcgtttc gccgggggca     9780

ggatggagca tccgggagac tgcctgtctt gcaaaatcat atgcacagat gtggcagctt     9840

ctttatttcc acagaagaga cctccgactg atggccaatg ccatttgctc ggccgtgcca     9900

gttgactggg tcccaactgg gagaactacc tggtcaatcc atggaaaggg agaatggatg     9960

actactgagg acatgctcat ggtgtggaat agagtgtgga ttgaggagaa tgatcacatg    10020

gaggacaaga cccctgtaac aaaatggaca gacattccct atttgggaaa aagggaggac    10080

ttatggtgtg gatcccttat aggacacaga cctcgcacca cttgggctga gaacatcaaa    10140

gacacagtca gcatggtgcg cagaatcata ggtgatgaag aaaagtacat ggactaccta    10200

tccactcaag ttcgctactt gggtgaggaa gggtctacac ctggagtgct gtaa          10254


<210>  85
<211>  10793
<212>  DNA
<213>  Zika virus isolate Brazil-ZKV2015, complete genome

<400>  85
ccaatctgtg aatcagactg cgacagttcg agtttgaagc gaaagctagc aacagtatca       60

acaggtttta ttttggattt ggaaacgaga gtttctggtc atgaaaaacc caaaaaagaa      120

atccggagga ttccggattg tcaatatgct aaaacgcgga gtagcccgtg tgagcccctt      180

tgggggcttg aagaggctgc cagccggact tctgctgggt catgggccca tcaggatggt      240

cttggcgatt ctagcctttt tgagattcac ggcaatcaag ccatcactgg gtctcatcaa      300

tagatggggt tcagtgggga aaaaagaggc tatggaaata ataaagaagt tcaagaaaga      360

tctggctgcc atgctgagaa taatcaatgc caggaaggag aagaagagac gaggcgcaga      420

tactagtgtc ggaatcgttg gcctcctgct gaccacagct atggcagcgg aggtcactag      480

acgtgggagt gcatactata tgtacttgga cagaaacgat gctggggagg ccatatcttt      540

tccaaccaca ttggggatga ataagtgtta tatacagatc atggatcttg gacacatgtg      600

tgatgccacc atgagctatg aatgccctat gctggatgag ggggtggaac cagatgacgt      660

cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac ggaacctgcc atcacaaaaa      720

aggtgaagca cggagatcta gaagagctgt gacgctcccc tcccattcca ctaggaagct      780

gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac acaaagcact tgattagagt      840

cgaaaattgg atattcagga accctggctt cgcgttagca gcagctgcca tcgcttggct      900

tttgggaagc tcaacgagcc aaaaagtcat atacttggtc atgatactgc tgattgcccc      960

ggcatacagc atcaggtgca taggagtcag caatagggac tttgtggaag gtatgtcagg     1020

tgggacttgg gttgatgttg tcttggaaca tgggggttgt gtcaccgtaa tggcacagga     1080

caaaccgact gtcgacatag agctggttac aacaacagtc agcaacatgg cggaggtaag     1140

atcctactgc tatgaggcat caatatcaga catggcttcg gacagccgct gcccaacaca     1200

aggtgaagcc taccttgaca agcaatcaga cactcaatat gtctgcaaaa gaacgttagt     1260

ggacagaggc tggggaaatg gatgtggact ttttggcaaa gggagcctgg tgacatgcgc     1320

taagtttgca tgctccaaga aaatgaccgg gaagagcatc cagccagaga atctggagta     1380

ccggataatg ctgtcagttc atggctccca gcacagtggg atgatcgtta atgacacagg     1440

acatgaaact gatgagaata gagcgaaggt tgagataacg cccaattcac caagagccga     1500

agccaccctg gggggttttg gaagcttagg acttgattgt gaaccgagga caggccttga     1560

cttttcagat ttgtattact tgactatgaa taacaagcac tggttggttc acaaggagtg     1620

gttccacgac attccattac cttggcacgc tggggcagac accggaactc cacactggaa     1680

caacaaagaa gcactggtag agttcaagga cgcacatgcc aaaaggcaaa ctgtcgtggt     1740

tctagggact caagaaggag cagttcacac ggcccttgct ggagctctgg aggctgagat     1800

ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa tgtcgcctga aaatggataa     1860

acttagattg aagggcgtgt catactcctt gtgtaccgca gcgttcacat tcaccaagat     1920

cccggctgaa acactgcacg ggacagtcac agtggaggta cagtacgcag ggacagatgg     1980

accttgcaag gttccagctc agatggcggt ggacatgcaa actctgaccc cagttgggag     2040

gttgataacc gctaaccccg taatcactga aagcactgag aactctaaga tgatgctgga     2100

acttgatcca ccatttgggg actcttacat tgtcatagga gtcggggaga agaagatcac     2160

ccaccactgg cacaggagtg gcagcaccat tggaaaagca tttgaagcca ctgtgagagg     2220

tgccaagaga atggcagtct tgggagacac agcctgggac tttggatcag ttggaggcgc     2280

tctcaactca ttgggcaagg gcatccatca aatttttgga gcagctttca aatcattgtt     2340

tggaggaatg tcctggttct cacaaattct cattggaacg ttgctgatgt ggttgggtct     2400

gaacacaaag aatggatcta tttcccttat gtgcttggcc ttagggggag tgttgatctt     2460

cttatccaca gccgtctctg ctgatgtggg gtgctcggtg gacttctcaa agaaggagac     2520

gagatgtggt acaggggtgt tcgtctataa cgacgttgaa gcctggaggg acaggtacaa     2580

gtaccatcct gactctcccc gtagattggc agcagcagtc aagcaagcct gggaagatgg     2640

tatctgcggg atctcctctg tttcaagaat ggaaaacatc atgtggagat cagtagaagg     2700

ggagcttaac gcaatcctgg aagagaatgg agttcaactg acggtcgttg tgggatctgt     2760

aaaaaacccc atgtggagag gtccacagag attgcccgtg cctgtgaacg agctgcccca     2820

cggctggaag gcttggggga aatcgtactt cgtcagagca gcaaagacaa ataacagctt     2880

tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa catagagcat ggaacagctt     2940

tcttgtggag gatcatgggt tcggggtatt tcacactagt gtctggctca aggttagaga     3000

agattattca ttagagtgtg atccagccgt tattggaaca gctgttaagg gaaaggaggc     3060

tgtacacagt gatctaggct actggattga gagtgagaag aatgacacat ggaggctgaa     3120

gagggcccat ctgatcgaga tgaaaacatg tgaatggcca aagtcccaca cattgtggac     3180

agatggaata gaagagagtg atctgatcat acccaagtct ttagctgggc cactcagcca     3240

tcacaatacc agagagggct acaggaccca aatgaaaggg ccatggcaca gtgaagagct     3300

tgaaattcgg tttgaggaat gcccaggcac taaggtccac gtggaggaaa catgtggaac     3360

aagaggacca tctctgagat caaccactgc aagcggaagg gtgatcgagg aatggtgctg     3420

cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa gatggctgtt ggtatggaat     3480

ggagataagg cccaggaaag aaccagaaag caacttagta aggtcaatgg tgactgcagg     3540

atcaactgat cacatggatc acttctccct tggagtgctt gtgattctgc tcatggtgca     3600

ggaagggctg aagaagagaa tgaccacaaa gatcatcata agcacatcaa tggcagtgct     3660

ggtagctatg atcctgggag gattttcaat gagtgacctg gctaagcttg caattttgat     3720

gggtgccacc ttcgcggaaa tgaacactgg aggagatgta gctcatctgg cgctgatagc     3780

ggcattcaaa gtcagaccag cgttgctggt atctttcatc ttcagagcta attggacacc     3840

ccgtgaaagc atgctgctgg ccttggcctc gtgttttttg caaactgcga tctccgcctt     3900

ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg gcctggttgg caatacgagc     3960

gatggttgtt ccacgcactg acaacatcac cttggcaatc ctggctgctc tgacaccact     4020

ggcccggggc acactgcttg tggcgtggag agcaggcctt gctacttgcg gggggtttat     4080

gctcctctct ctgaagggaa aaggcagtgt gaagaagaac ttaccatttg tcatggccct     4140

gggactaacc gctgtgaggc tggtcgaccc catcaacgtg gtgggactgc tgttgctcac     4200

aaggagtggg aagcggagct ggccccctag cgaagtactc acagctgttg gcctgatatg     4260

cgcattggct ggagggttcg ccaaggcaga tatagagatg gctgggccca tggccgcggt     4320

cggtctgcta attgtcagtt acgtggtctc aggaaagagt gtggacatgt acattgaaag     4380

agcaggtgac atcacatggg aaaaagatgc ggaagtcact ggaaacagtc cccggctcga     4440

tgtggcgcta gatgagagtg gtgacttctc cctggtggag gatgacggtc cccccatgag     4500

agagatcata ctcaaggtgg tcctgatgac catctgtggc atgaacccaa tagccatacc     4560

ctttgcagct ggagcgtggt acgtatacgt gaagactgga aaaaggagtg gtgctctatg     4620

ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc acagatggag tgtacagagt     4680

aatgactcgt agactgctag gttcaacaca agttggagtg ggagttatgc aagagggggt     4740

ctttcacact atgtggcacg tcacaaaagg atccgcgctg agaagcggtg aagggagact     4800

tgatccatac tggggagatg tcaagcagga tctggtgtca tactgtggtc catggaagct     4860

agatgccgcc tgggacgggc acagcgaggt gcagctcttg gccgtgcccc ccggagagag     4920

agcgaggaac atccagactc tgcccggaat atttaagaca aaggatgggg acattggagc     4980

ggttgcgctg gattacccag caggaacttc aggatctcca atcctagaca agtgtgggag     5040

agtgatagga ctttatggca atggggtcgt gataaaaaat gggagttatg ttagtgccat     5100

cacccaaggg aggagggagg aagagactcc tgttgagtgc ttcgagcctt cgatgctgaa     5160

gaagaagcag ctaactgtct tagacttgca tcctggagct gggaaaacca ggagagttct     5220

tcctgaaata gtccgtgaag ccataaaaac aagactccgt actgtgatct tagctccaac     5280

cagggttgtc gctgctgaaa tggaggaagc ccttagaggg cttccagtgc gttatatgac     5340

aacagcagtc aatgtcaccc actctggaac agaaatcgtc gacttaatgt gccatgccac     5400

cttcacttca cgtctactac agccaatcag agtccccaac tataatctgt atattatgga     5460

tgaggcccac ttcacagatc cctcaagcat agcagcaaga ggatacattt caacaagggt     5520

tgagatgggc gaggcggctg ccatcttcat gaccgccacg ccaccaggaa cccgtgacgc     5580

atttccggac tccaactcac caattatgga caccgaagtg gaagtcccag agagagcctg     5640

gagctcaggc tttgattggg tgacggatca ttctggaaaa acagtttggt ttgttccaag     5700

cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag gctggaaaac gggtcataca     5760

gctcagcaga aagacttttg agacagagtt ccagaaaaca aaacatcaag agtgggactt     5820

tgtcgtgaca actgacattt cagagatggg cgccaacttt aaagctgacc gtgtcataga     5880

ttccaggaga tgcctaaagc cggtcatact tgatggcgag agagtcattc tggctggacc     5940

catgcctgtc acacatgcca gcgctgccca gaggaggggg cgcataggca ggaatcccaa     6000

caaacctgga gatgagtacc tgtatggagg tgggtgcgca gagactgacg aagaccatgc     6060

acactggctt gaagcaagaa tgctccttga caatatttac ctccaagatg gcctcatagc     6120

ctcgctctat cgacctgagg ccgacaaagt agcagccatt gagggagagt tcaagcttag     6180

gacggagcaa aggaagacct ttgtggaact catgaaaaga ggagatcttc ctgtttggct     6240

ggcctatcag gttgcatctg ccggaataac ctacacagat agaagatggt gctttgatgg     6300

cacgaccaac aacaccataa tggaagacag tgtgccggca gaggtgtgga ccagacacgg     6360

agagaaaaga gtgctcaaac cgaggtggat ggacgccaga gtttgttcag atcatgcggc     6420

cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga gcggcttttg gagtgatgga     6480

agccctggga acactgccag gacacatgac agagagattc caggaagcca ttgacaacct     6540

cgctgtgctc atgcgggcag agactggaag caggccttac aaagccgcgg cggcccaatt     6600

gccggagacc ctagagacca ttatgctttt ggggttgctg ggaacagtct cgctgggaat     6660

ctttttcgtc ttgatgagga acaagggcat agggaagatg ggctttggaa tggtgactct     6720

tggggccagc gcatggctca tgtggctctc ggaaattgag ccagccagaa ttgcatgtgt     6780

cctcattgtt gtgttcctat tgctggtggt gctcatacct gagccagaaa agcaaagatc     6840

tccccaggac aaccaaatgg caatcatcat catggtagca gtaggtcttc tgggcttgat     6900

taccgccaat gaactcggat ggttggagag aacaaagagt gacctaagcc atctaatggg     6960

aaggagagag gagggggcaa ccataggatt ctcaatggac attgacctgc ggccagcctc     7020

agcttgggcc atctatgctg ccttgacaac tttcattacc ccagccgtcc aacatgcagt     7080

gaccacttca tacaacaact actccttaat ggcgatggcc acgcaagctg gagtgttgtt     7140

tggtatgggc aaagggatgc cattctacgc atgggacttt ggagtcccgc tgctaatgat     7200

aggttgctac tcacaattaa cacccctgac cctaatagtg gccatcattt tgctcgtggc     7260

gcactacatg tacttgatcc cagggctgca ggcagcagct gcgcgtgctg cccagaagag     7320

aacggcagct ggcatcatga agaaccctgt tgtggatgga atagtggtga ctgacattga     7380

cacaatgaca attgaccccc aagtggagaa aaagatggga caggtgctac tcatagcagt     7440

agccgtctcc agcgccatac tgtcgcggac cgcctggggg tggggggagg ctggggccct     7500

gatcacagcc gcaacttcca ctttgtggga aggctctccg aacaagtact ggaactcctc     7560

tacagccact tcactgtgta acatttttag gggaagttac ttggctggag cttctctaat     7620

ctacacagta acaagaaacg ctggcttggt caagagacgt gggggtggaa caggagagac     7680

cctgggagag aaatggaagg cccgcttgaa ccagatgtcg gccctggagt tctactccta     7740

caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc cgccgcgccc tcaaggacgg     7800

tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca aagctgagat ggttggtgga     7860

gcggggatac ctgcagccct atggaaaggt cattgatctt ggatgtggca gagggggctg     7920

gagttactac gccgccacca tccgcaaagt tcaagaagtg aaaggataca caaaaggagg     7980

ccctggtcat gaagaacccg tgttggtgca aagctatggg tggaacatag tccgtcttaa     8040

gagtggggtg gacgtctttc atatggcggc tgagccgtgt gacacgttgc tgtgtgacat     8100

aggtgagtca tcatctagtc ctgaagtgga agaagcacgg acgctcagag tcctctccat     8160

ggtgggggat tggcttgaaa aaagaccagg agccttttgc ataaaagtgt tgtgcccata     8220

caccagcact atgatggaaa ccctggagcg actgcagcgt aggtatgggg gaggactggt     8280

cagagtgcca ctctcccgca actctacaca tgagatgtac tgggtctctg gagcgaaaag     8340

caacaccata aaaagtgtgt ccaccacgag ccagctcctc ttggggcgca tggacgggcc     8400

taggaggcca gtgaaatatg aggaggatgt gaatctcggc tctggcacgc gggctgtggt     8460

aagctgcgct gaagctccca acatgaagat cattggtaac cgcattgaaa ggatccgcag     8520

tgagcacgcg gaaacgtggt tctttgacga aaaccaccca tataggacat gggcttacca     8580

tggaagctat gtggccccca cacaagggtc agcgtcctct ctaataaacg gggttgtcag     8640

gctcctgtca aaaccctggg atgtggtgac tggagtcaca ggaatagcca tgaccgacac     8700

cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg gacactaggg tgccagaccc     8760

ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc tggttgtgga aagagctagg     8820

caaacacaaa cgaccacgag tctgtaccaa agaagagttc atcaacaagg ttcgtagcaa     8880

tgcagcatta ggggcaatat ttgaagagga aaaagagtgg aagactgcag tggaagctgt     8940

gaacgatcca aggttctggg ctctagtgga caaggaaaga gagcaccacc tgagaggaga     9000

gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa aagaaacaag gggaatttgg     9060

aaaggccaag ggcagccgcg ccatctggta tatgtggcta ggggctagat ttctagagtt     9120

cgaagccctt ggattcttga acgaggatca ctggatgggg agagagaact caggaggtgg     9180

tgttgaaggg ctgggattac aaagactcgg atatgtccta gaagagatga gtcgcatacc     9240

aggaggaagg atgtatgcag atgacactgc tggctgggac acccgcatca gcaggtttga     9300

tctggagaat gaagctctaa tcaccaacca aatggagaaa gggcacaggg ccttggcatt     9360

ggccataatc aagtacacat accaaaacaa agtggtaaag gtccttagac cagctgaaaa     9420

agggaaaaca gttatggaca ttatttcgag acaagaccaa agggggagcg gacaagttgt     9480

cacttacgct cttaacacat ttaccaacct agtggtgcaa ctcattcgga atatggaggc     9540

tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg aggtcagaga aagtgaccaa     9600

ctggttgcag agcaacggat gggataggct caaacgaatg gcagtcagtg gagatgattg     9660

cgttgtgaag ccaattgatg ataggtttgc acatgccctc aggttcttga atgatatggg     9720

aaaagttagg aaggacacac aagagtggaa accctcaact ggatgggaca actgggaaga     9780

agttccgttt tgctcccacc acttcaacaa gctccatctc aaggacggga ggtccattgt     9840

ggttccctgc cgccaccaag atgaactgat tggccgggcc cgcgtctctc caggggcggg     9900

atggagcatc cgggagactg cttgcctagc aaaatcatat gcgcaaatgt ggcagctcct     9960

ttatttccac agaagggacc tccgactgat ggccaatgcc atttgttcat ctgtgccagt    10020

tgactgggtt ccaactggga gaactacctg gtcaatccat ggaaagggag aatggatgac    10080

cactgaagac atgcttgtgg tgtggaacag agtgtggatt gaggagaacg accacatgga    10140

agacaagacc ccagttacga aatggacaga cattccctat ttgggaaaaa gggaagactt    10200

gtggtgtgga tctctcatag ggcacagacc gcgcaccacc tgggctgaga acattaaaaa    10260

tacagtcaac atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actacctatc    10320

cacccaagtt cgctacttgg gtgaagaagg gtctacacct ggagtgctgt gagcaccaat    10380

cttaatgttg tcaggcctgc tagtcagcca cagcttgggg aaagctgtgc agcctgtgac    10440

ccctccagga gaagctgggt aaccaagcct atagtcaggc cgagaacgcc atggcacgga    10500

agaagccatg ctgcctgtga gcccctcaga ggacactgag tcaaaaaacc ccacgcgctt    10560

ggaggcgcag gatgggaaaa gaaggtggcg accttcccca cccttcaatc tggggcctga    10620

actggagatc agctgtggat ctccagaaga gggactagtg gttagaggag accccccgga    10680

aaacgcaaaa cagcatattg acgctgggaa agaccagaga ctccatgagt ttccaccacg    10740

ctggccgcca ggcacagatc gccgaatagc ggcggccggt gtggggaaat cca           10793


<210>  86
<211>  10290
<212>  DNA
<213>  Spondweni virus strain SM-6 V-1 polyprotein gene, complete cds

<400>  86
atgaaaaacc caaaaagagc cggtagcagc cggcttgtca atatgctaag acgcggtgca       60

gcccgtgtca tccctccagg aggagggctc aagaggctgc ctgtaggatt gctgttgggt      120

cggggtccga tcaaaatgat cctggccata ctggcattcc tacgatttac agcaataaaa      180

ccgtccactg gcctcatcaa cagatgggga aaagtgggca aaaaagaggc catcaaaatc      240

ctcacaaaat tcaaggctga cgtgggcacc atgctgcgta tcatcaacaa tcggaagaca      300

aaaaagagag gagtcgaaac tggaattgtg ttcctggcat tgctggtgtc tattgttgct      360

gtggaagtca caaaaaaggg ggacacctat tacatgtttg cggacaagaa ggacgccgga      420

aaggtggtga cctttgagac tgaatctgga cccaaccgtt gctccatcca agcaatggac      480

attggacata tgtgtccagc tacaatgagc tatgaatgtc ccgtgctgga accacagtat      540

gagccagagg atgtcgactg ttggtgcaac tcgacagcag catggattgt gtatggcaca      600

tgcacccaca agacaacggg agagacaaga cgttccagac gttcaatcac cctgccatct      660

catgcctcac aaaagttgga gaccagatca tcgacgtggc ttgaatcccg cgaatactcc      720

aaatatctaa taaaggtgga aaactggatc ctccgcaatc caggatatgc gttggtggct      780

gcagtgattg gatggactct gggcagcagt cgcagccaga agatcatctt tgtcactctg      840

ctcatgttgg tagcccccgc atacagcatc agatgcattg gaattggaaa cagagacttc      900

attgagggaa tgtccggtgg cacctgggtg gacattgtcc tggaacatgg tggttgtgtg      960

acagtaatgt caaacgacaa acccacattg gactttgaac tggtgacaac gaccgcaagt     1020

aacatggctg aggtcaggtc ctactgctat gaagctaaca tatccgagat ggcatcggac     1080

agcaggtgcc ccacacaggg ggaagcttat cttgacaaaa tggccgactc ccagtttgtg     1140

tgcaagcgtg ggtacgttga caggggctgg ggaaacggat gtggactctt tggaaaagga     1200

agcattgtca cttgcgctaa gttcacgtgt gtgaaaaagc tcacagggaa aagcattcaa     1260

ccggagaatc tcgagtaccg ggtccttgtt tcggtgcacg cttcccaaca tggaggaatg     1320

attaacaatg acaccaatca ccaacacgac aaggagaaca gagcgcgcat tgatatcaca     1380

gctagcgctc cccgtgttga ggtggaactt ggctcctttg gatccttctc gatggagtgt     1440

gaaccccggt caggattgaa ctttggtgac ctgtattacc tcaccatgaa caacaagcat     1500

tggctggtta atagagattg gtttcacgat ctttccttgc catggcatac aggagccaca     1560

tcaaacaatc atcactggaa caacaaggag gcgctggtag aattcagaga agcccacgca     1620

aagaagcaga cggctgtggt cctgggaagt caggaaggag ctgttcacgc agcactggcc     1680

ggcgcactgg aggctgagtc tgatggacac aaagcgacta tctactctgg acacttgaag     1740

tgtcgcttga agctagacaa actgcgcctg aagggaatgt catatgcact ctgcacagga     1800

gcattcacct tcgctcgcac cccctctgaa acaattcacg gcaccgccac agtggagctg     1860

caatatgcag gtgaagatgg gccgtgcaaa gttcccatag taattaccag tgacaccaat     1920

agcatggcct cgacaggcag gctgatcaca gcgaatccgg tggtcacgga aagtggagca     1980

aactcaaaga tgatggtcga gattgaccct ccgtttggtg attcttacat tattgtgggc     2040

actggcacaa caaaaattac ccaccattgg cacagagccg gtagttcaat tggacgtgca     2100

tttgaggcta ccatgagagg agcaaaacgg atggcggtcc tcggcgacac cgcttgggac     2160

tttggctctg ttgggggcat gttcaactcc gttggaaagt ttgtccacca ggtgtttgga     2220

tcagcattta aggcattgtt tggaggcatg tcctggttca cacagctcct gataggattt     2280

ctgctcatat ggatgggttt gaacgcacgc ggtggaaccg tggccatgag cttcatgggc     2340

attggggcta tgctgatttt cctagccacc tcggtgtcag gagacacagg atgctcggtt     2400

gacatatcca gaagggaaat gcggtgcggg agcggcatat tcgtgtacaa tgacgttgac     2460

gcatggcgaa gccgctacaa ataccatcct gaaaccccca gagctttggc cgctgccgtg     2520

aaaacggctt gggaagaagg gacctgtggc attacctcag tgagcagaat ggaaaacctg     2580

atgtggagct ctgtggctgg agagttgaat gcaatccttg aggacaattc agtgccattg     2640

acagtcgtcg ttggcgagcc aaaatatcca ctgtacaatg ctccaaagag gctgaaacca     2700

ccagcatcag agttaccgca ggggtggaag tcctggggaa agtcatactt tgtctcagcc     2760

gcaaaaaaca acaactcctt tgtggtagat ggtgacacca tgaaggaatg cccaagacag     2820

aagcgagcat ggaacagctt gagaatagag gatcatgggt tcggagtctt ccacactagc     2880

atctggctga aattccatga ggacaactcc accgaatgtg acacagctat cataggaacg     2940

gcggttcgcg ggaaggaagc cgttcatagt gacttgggct actggataga gagtgagcgc     3000

aatgacacat ggaggctctc tcgagcgcac ctgatcgaag caaagacatg tgaatggcca     3060

cggtcgcaca cactgtggac ggacggagtg gaagagagcg agctgatcat tccacgtggc     3120

ttagccggtc ctttcagcca tcataacacg cgtgctggct acaagactca gaataaaggt     3180

ccctggcatt taggtgatgt tgaaattcag ttcgccacgt gccccggaac aaccgtggtc     3240

caggaccaag agtgcaggga caggggcgct tctctacgca cgaccacagc tagtggaagg     3300

gtaatcaatg aatggtgctg caggtcgtgc accatgcctc cactcagttt caagacaaaa     3360

gatggatgtt ggtatgcaat ggagatacgt cctgtgaaag aacaagagtc aaacctcgtg     3420

cgatcgcacg tcactgccgg aagcacagac cacatggacc atttctctct cggattagta     3480

gtggtcatgt tgatggtgca agaaggtatg aagaagagaa tgacatcaaa agcaataatc     3540

acctcagcgg cctttctcct ggcggttatg atagtgggag gtttcacgta ccaggatttt     3600

gggaggctgg tggtattggt gggtgctgca tttgctgaga tgaacactgg aggtgacgtt     3660

gcgcacctgg cgctggtggc agcgtttaaa gtgaggccag cgatgctggt ctcattcatg     3720

ttcagagcct tgtggacccc cagggagtca ctgcttttag ctctggctgc ctgcctcctg     3780

caggtgtcag tgacaccact ggatcattcc atcatgatcg tggttgatgg gattgcgctg     3840

tcctggttgt gtctgaaagc catcttggtg ccgcgtaccc caaacatagc ccttcctctt     3900

ctcgctatgc tgtcacccat gctccaaggt accaccattg tggcatggcg agctatgatg     3960

gcggccctgg ctgtcataac cttggcttcc atgaagcatg gaaggggtgt aaaaaagacg     4020

tttccctaca ccatcggatg catccttggc agcatgggct tagttgaaaa cttggggttg     4080

gttggcctcc tcttgttgac agcctcaaaa aagaggagtt ggcctccgag tgaggtgatg     4140

acggctgtcg gactgatctg tgcaattgtg ggcggactaa ccaagaccga cattgacatg     4200

gcgggaccca tggcagccat aggactgctg gtggtgagct atgtggtttc tggcaagagt     4260

gtggacatgt acattgaaaa ggtgtgtgac atatcatggg acaaggacgc tgaaataaca     4320

ggcacaagtc cgcggctgga tgtggctctc gacgacagtg gagatttctc acttatccag     4380

gatgacgggc cccccactcg agagattgtg ttgaaggtgt ttctgatgtg tgtttgcggt     4440

gtcagcccca tagccatccc ctttgcagcc gctgcttggt tcgtgtacat taaatcaggg     4500

aaaagaagcg gcgccatgtg ggacattcca tccccaagag aagtgaaaaa aggggaaaca     4560

acggctggag tgtacagaat catgacgcgt aaattgctgg gcagcacaca ggtgggagcc     4620

ggagtaatgc atgaaggtgt ttttcacaca atgtggcacg tcacaaaagg ttcggccctt     4680

cggagtggtg agggacgcct agatccatac tggggaaacg tgaagcagga tttgatctct     4740

tactgcggac catggaaact ggatgggaaa tgggacggcg tgtcggaagt ccaactgata     4800

gcggtcgccc caggtgagcg cgccagaaat gtgcagacaa aaccaggagt gttcaagacc     4860

actgatgggg aaatcggggc cttggccctt gacttcccag gcggaagttc aggctccccg     4920

ataattgaca aaaatggaca tgtaattggc ctgtatggaa atggtgtcgt ggtcaagagt     4980

ggaagctacg tgagtgccat catgcagaca gagaagatgg aggaacccgc agttgactgc     5040

tttgaggagg acatgctgag aaaaaagaag ctgacggtgc tcgacctcca tccaggagct     5100

ggaaaaactc gaagagtgct ccctcagatc gtcaaggctg caattaagaa acgcctacgc     5160

acggtaatcc tggcacccac ccgagtggtg gcagctgaga tggctgaggc actaaaagac     5220

cttccaataa ggtacatgac tccggcagtt tcagccaccc atgatggcaa tgagattgtt     5280

gaccttatgt gccacgccac ttttacatca aggctaatgc aaccaattag ggtgcctaat     5340

tacaatctat atataatgga tgaggcccac ttcacagatc ctgcaagcat cgctgcaaga     5400

gggtacatag caacaagagt ggacatggga gacgccgcgg ccatcttcat gacggccacc     5460

cctcctggca gcactgaagc tttcccggat tcaaacgccc ccatcacaga tgttgaaaca     5520

gaggttcctg acaaggcgtg gaattctgga tttgaatgga tcactgatta cccagggaaa     5580

accgtttggt ttgtccctag tgtcagaatg ggcaatgaga tctcggcctg cctcacaaaa     5640

gccggcaaat cggttatcca actcagccgg aaaacctttg aaacagagta ccagaagaca     5700

aagaatggtg agtgggactt tgtcgtgacc actgacatct cagaaatggg agccaacttc     5760

aaggccgaca gagtcataga ctcacggaaa tgcttgaagc cagtgattct ggatgacatg     5820

gaagagagag ttgttcttgc cgggccgatg gcagtaacac catccagcgc agctcaacgc     5880

agaggaagaa ttggaagaaa ccccaacaaa actggagatg agttctatta cggggggggc     5940

tgtgccgcaa cggatgatga ccatgctcat tgggtagagg ctaggatgct gcttgacaac     6000

atctacctcc aggacaacct cgttgcatct ctgtacaagc cagaacaagg aaaggtctcg     6060

gcaatagaag gggagttcaa actgagagga gaacagagga aaaccttcgt ggagctgatg     6120

aagagagggg acttgccagt gtggttgtca tatcaagtgg cggcctccgg actcagctat     6180

actgaccggc gctggtgctt tgatggaaaa aacaacaaca ccatcctgga ggactgcgtc     6240

cccgtcgagg tgtggacaaa atttggagag aaaaagattc tgaagcccag atggatggac     6300

gctcggatct gctctgatca tgcctctttg aagtctttca aggagtttgc tgcaggaaag     6360

agaacaatag ccactggctt aattgaggct tttgggatgc ttcccgggca catgactgag     6420

agattccagg aggccgtcga caatttggcc gtgttgatga gggccgaggc aggctctagg     6480

gcacacagaa tggctgcagc acagctccct gagacaatgg aaaccatcct gctcctcagc     6540

ctgctggcat tcgtgtcact tggtgtattt tttgtactga tgagggcaaa agggttagga     6600

aaaatggggt ccggcatgat cgtgctggca ggaagtggct ggctcatgtg gatgtctgag     6660

gtggaaccag cccgcatagc ttgtgtggtg atcatagtgt ttctgctaat ggtcgttctg     6720

attccggaac cggagaagca gcgctctccc caggacaatc agctggctct aattatcttg     6780

atcgcgacgg gcctcatcac gctcatcgcg gccaatgagc tgggttggtt agaaagaaca     6840

aagagtgacc tcaccaggct gttttggaga gaacacgctg agccaacagg agggagaggg     6900

ttttccttct cgctggacat tgacctgcgg ccggcatcgg cctgggcaat atatgccgct     6960

atgacaaccc tgatcacacc gacagtccaa cacgctgtga ccacatcgta caacaactac     7020

tctctcatgg ctatggccac tcaggccgga gttctttttg gcatgggacg gggggtgcct     7080

ttttacaaat gggactttgg cgtgccactc cttatgctgg gctgctactc acaacttacc     7140

ccactcaccc tgatcgtggc tctcgtgatg ctagccgctc actatctcta tctcatcccc     7200

gggctccagg caacggccgc cagggccgcc caacgaagga cggctgctgg aataatgaaa     7260

aacccagtgg tggatggaat tgtggtaact gacatagacc caatccaaat cgatccaaat     7320

gtcgaaaaga agatgggcca ggtcatgctc atctttgtgg ctttggcgag cgcggttctc     7380

atgagaacgg catggggttg gggagaggct ggtgcccttg catcggcagc agctgccacc     7440

ctatgggaag gggctcccaa caagtactgg aattcatcaa cggctacatc cttgtgcaac     7500

atatttcggg gaagttatct ggcaggtccc tccctcatct acaccgtcac acgcaatgca     7560

ggtatcatga agaaaagggg cggtggaaat ggagaaacgg tgggcgagaa atggaaggag     7620

cgcttgaatc ggatgaccgc gcttgaattc tacgcctaca agcggtcagg aataactgaa     7680

gtgtgcagag aacccgccag aagagccttg aaggatggag tcgtcacagg aggacacgct     7740

gtctcccgcg gaagcgcaaa gctgcgatgg atggtggaac gtggccacgt caatctagtg     7800

ggacgcgttg tcgacctcgg atgtggaagg ggtggctgga gttactacgc cgcatctcaa     7860

aagcaagtcc tcgaggtgag aggctacaca aaagggggag cgggccacga ggagcccatg     7920

aatgtccaaa gttatggttg gaacatagtg cgactcaaga gtggagtgga cgttttttat     7980

ctaccatcag aaccatgtga cacgctgctc tgtgacattg gagagtcatc ctcgagccca     8040

gcagtggaag aagcccggac tctgagagtg ctcgggatgg ttgaaacctg gctggaacgg     8100

ggcgtaaaga acttctgcat caaagtgctc tgcccgtaca ccagtgccat gattgagcgg     8160

ctggaagccc tccagcgtcg ctacggagga ggcctggtga gggttccact ctccagaaat     8220

tccacccacg aaatgtactg ggtctctgga gcaaaatcaa acatcatcag gagtgtgaat     8280

gccaccagcc agctgctcat gcacagaatg gacatcccca cgcggaaaac aaagtttgaa     8340

gaagacgtca atctggggac cggaaccagg gcagttgaaa gcagagctga ccctcccgac     8400

atgaaaaaac taggcagccg gattgagcgg ttgagaaagg aatatggatc cacttggcac     8460

tacgatgaaa accaccccta caggacatgg cattaccacg gcagttatga ggctgacacg     8520

caaggctccg cctcctcaat ggtcaacggc gtggtgcgtc tcctctcaaa accatgggat     8580

gcattgagct cggtcaccaa cattgctatg acggacacaa ctccgtttgg acagcagcgg     8640

gtgttcaagg agaaagtgga cacccggact ccagacccca agcagggcac gcaaagagtc     8700

atggccataa catcacaatg gctgtgggac cgcctagcaa gaaacaagac ccctcggatg     8760

tgcacgcgac aggaattcat aaacaaggtc aacagtcacg cggcgttggg acccgttttt     8820

agagaacagc agggatgggg ttcagcggcc gaagcggtgg tagatcctag gttttgggag     8880

ctcgttgaca atgaaagaga agcccatttg agaggggagt gcttgacctg tgtctacaac     8940

atgatgggga aaagagaaaa gaagctcggt gaattcggga aggcaaaagg cagcagagcc     9000

atttggtaca tgtggctggg agcccgcttc ctcgagttcg aggccctggg cttcctcaat     9060

gaagaccact ggttaagcag agagaactct ggagggggag ttgagggctt gggcctccaa     9120

aaacttggat acatccttga agagatcagc aggaggccag gaggcaaaat gtatgccgat     9180

gacacggctg gctgggacac ccgcatcacg aaatgcgacc tagaaaatga ggcgcgcatt     9240

ttggaaaaaa tggacgggat ccacaaaaaa ctcgcacggg ccgtcatcga gttgacatac     9300

aagcataagg ttgtgagagt cttgagacca gcaccacaag ggaaggtcgt tatggacatc     9360

atctccaggc cagaccaaag ggggagtggg caggtggtta cttatgccct caacacctat     9420

acaaacttgg tggtgcagct gatccgtaac atggaagcag aggctgtcat caatgaaaga     9480

gacatggagg agctccaaaa cccatggaaa gtcatcaatt ggctagaagg aaatggatgg     9540

gacagactcc gctcgatggc agtgagtgga gatgactgtg tcgtgaaacc aatggatgat     9600

aggttcgcct atgcactgaa tttcctcaat gacatgggca aggtcagaaa agatgtccag     9660

gaatggaagc cctcgccggg gtggacaaac tgggaagaag tgcccttttg ctcccaccac     9720

ttcaacaagc tcccgatgaa ggatggaaga acaataatag ttccctgccg gcaccaagat     9780

gagttgatag gcagggctag agtttctcca ggaaaaggct ggtcactcag tgaaacagca     9840

tgcttgggca agtcttatgc ccagatgtgg ctactgttgt actttcacag gagagatctc     9900

cgactcatgg caaacgcaat ctgctctgct gtaccggtga gttgggtgcc cacggggaga     9960

acaacctggt ccatccatgg gcgtggagag tggatgacaa cagaggacat gctagaggta    10020

tggaacagag tgtggatcat agagaatgag tacatggagg acaagacccc tgtcacagag    10080

tggaccgatg ttccatactt gggaaagaga gaagacttgt ggtgcggctc ccttattgga    10140

cacaggccaa gaagcacatg ggcagagaac atctgggctg ccatttatca agtgcgccga    10200

gcaatcggcg aaactgaaga atatagagac tacatgagca cacaggtccg ctatggctcg    10260

gaggaagggc caagcgctgg tgtgttgtaa                                     10290


<210>  87
<211>  10290
<212>  DNA
<213>  Spondweni virus, complete genome NCBI Reference Sequence: NC_029055.1

<400>  87
atgaaaaacc caaaaagagc cggtagcagc cggcttgtca atatgctaag acgcggtgca       60

gcccgtgtca tccctccagg aggagggctc aagaggctgc ctgtaggatt gctgttgggt      120

cggggtccga tcaaaatgat cctggccata ctggcattcc tacgatttac agcaataaaa      180

ccgtccactg gcctcatcaa cagatgggga aaagtgggca aaaaagaggc catcaaaatc      240

ctcacaaaat tcaaggctga cgtgggcacc atgctgcgta tcatcaacaa tcggaagaca      300

aaaaagagag gagtcgaaac tggaattgtg ttcctggcat tgctggtgtc tattgttgct      360

gtggaagtca caaaaaaggg ggacacctat tacatgtttg cggacaagaa ggacgccgga      420

aaggtggtga cctttgagac tgaatctgga cccaaccgtt gctccatcca agcaatggac      480

attggacata tgtgtccagc tacaatgagc tatgaatgtc ccgtgctgga accacagtat      540

gagccagagg atgtcgactg ttggtgcaac tcgacagcag catggattgt gtatggcaca      600

tgcacccaca agacaacggg agagacaaga cgttccagac gttcaatcac cctgccatct      660

catgcctcac aaaagttgga gaccagatca tcgacgtggc ttgaatcccg cgaatactcc      720

aaatatctaa taaaggtgga aaactggatc ctccgcaatc caggatatgc gttggtggct      780

gcagtgattg gatggactct gggcagcagt cgcagccaga agatcatctt tgtcactctg      840

ctcatgttgg tagcccccgc atacagcatc agatgcattg gaattggaaa cagagacttc      900

attgagggaa tgtccggtgg cacctgggtg gacattgtcc tggaacatgg tggttgtgtg      960

acagtaatgt caaacgacaa acccacattg gactttgaac tggtgacaac gaccgcaagt     1020

aacatggctg aggtcaggtc ctactgctat gaagctaaca tatccgagat ggcatcggac     1080

agcaggtgcc ccacacaggg ggaagcttat cttgacaaaa tggccgactc ccagtttgtg     1140

tgcaagcgtg ggtacgttga caggggctgg ggaaacggat gtggactctt tggaaaagga     1200

agcattgtca cttgcgctaa gttcacgtgt gtgaaaaagc tcacagggaa aagcattcaa     1260

ccggagaatc tcgagtaccg ggtccttgtt tcggtgcacg cttcccaaca tggaggaatg     1320

attaacaatg acaccaatca ccaacacgac aaggagaaca gagcgcgcat tgatatcaca     1380

gctagcgctc cccgtgttga ggtggaactt ggctcctttg gatccttctc gatggagtgt     1440

gaaccccggt caggattgaa ctttggtgac ctgtattacc tcaccatgaa caacaagcat     1500

tggctggtta atagagattg gtttcacgat ctttccttgc catggcatac aggagccaca     1560

tcaaacaatc atcactggaa caacaaggag gcgctggtag aattcagaga agcccacgca     1620

aagaagcaga cggctgtggt cctgggaagt caggaaggag ctgttcacgc agcactggcc     1680

ggcgcactgg aggctgagtc tgatggacac aaagcgacta tctactctgg acacttgaag     1740

tgtcgcttga agctagacaa actgcgcctg aagggaatgt catatgcact ctgcacagga     1800

gcattcacct tcgctcgcac cccctctgaa acaattcacg gcaccgccac agtggagctg     1860

caatatgcag gtgaagatgg gccgtgcaaa gttcccatag taattaccag tgacaccaat     1920

agcatggcct cgacaggcag gctgatcaca gcgaatccgg tggtcacgga aagtggagca     1980

aactcaaaga tgatggtcga gattgaccct ccgtttggtg attcttacat tattgtgggc     2040

actggcacaa caaaaattac ccaccattgg cacagagccg gtagttcaat tggacgtgca     2100

tttgaggcta ccatgagagg agcaaaacgg atggcggtcc tcggcgacac cgcttgggac     2160

tttggctctg ttgggggcat gttcaactcc gttggaaagt ttgtccacca ggtgtttgga     2220

tcagcattta aggcattgtt tggaggcatg tcctggttca cacagctcct gataggattt     2280

ctgctcatat ggatgggttt gaacgcacgc ggtggaaccg tggccatgag cttcatgggc     2340

attggggcta tgctgatttt cctagccacc tcggtgtcag gagacacagg atgctcggtt     2400

gacatatcca gaagggaaat gcggtgcggg agcggcatat tcgtgtacaa tgacgttgac     2460

gcatggcgaa gccgctacaa ataccatcct gaaaccccca gagctttggc cgctgccgtg     2520

aaaacggctt gggaagaagg gacctgtggc attacctcag tgagcagaat ggaaaacctg     2580

atgtggagct ctgtggctgg agagttgaat gcaatccttg aggacaattc agtgccattg     2640

acagtcgtcg ttggcgagcc aaaatatcca ctgtacaatg ctccaaagag gctgaaacca     2700

ccagcatcag agttaccgca ggggtggaag tcctggggaa agtcatactt tgtctcagcc     2760

gcaaaaaaca acaactcctt tgtggtagat ggtgacacca tgaaggaatg cccaagacag     2820

aagcgagcat ggaacagctt gagaatagag gatcatgggt tcggagtctt ccacactagc     2880

atctggctga aattccatga ggacaactcc accgaatgtg acacagctat cataggaacg     2940

gcggttcgcg ggaaggaagc cgttcatagt gacttgggct actggataga gagtgagcgc     3000

aatgacacat ggaggctctc tcgagcgcac ctgatcgaag caaagacatg tgaatggcca     3060

cggtcgcaca cactgtggac ggacggagtg gaagagagcg agctgatcat tccacgtggc     3120

ttagccggtc ctttcagcca tcataacacg cgtgctggct acaagactca gaataaaggt     3180

ccctggcatt taggtgatgt tgaaattcag ttcgccacgt gccccggaac aaccgtggtc     3240

caggaccaag agtgcaggga caggggcgct tctctacgca cgaccacagc tagtggaagg     3300

gtaatcaatg aatggtgctg caggtcgtgc accatgcctc cactcagttt caagacaaaa     3360

gatggatgtt ggtatgcaat ggagatacgt cctgtgaaag aacaagagtc aaacctcgtg     3420

cgatcgcacg tcactgccgg aagcacagac cacatggacc atttctctct cggattagta     3480

gtggtcatgt tgatggtgca agaaggtatg aagaagagaa tgacatcaaa agcaataatc     3540

acctcagcgg cctttctcct ggcggttatg atagtgggag gtttcacgta ccaggatttt     3600

gggaggctgg tggtattggt gggtgctgca tttgctgaga tgaacactgg aggtgacgtt     3660

gcgcacctgg cgctggtggc agcgtttaaa gtgaggccag cgatgctggt ctcattcatg     3720

ttcagagcct tgtggacccc cagggagtca ctgcttttag ctctggctgc ctgcctcctg     3780

caggtgtcag tgacaccact ggatcattcc atcatgatcg tggttgatgg gattgcgctg     3840

tcctggttgt gtctgaaagc catcttggtg ccgcgtaccc caaacatagc ccttcctctt     3900

ctcgctatgc tgtcacccat gctccaaggt accaccattg tggcatggcg agctatgatg     3960

gcggccctgg ctgtcataac cttggcttcc atgaagcatg gaaggggtgt aaaaaagacg     4020

tttccctaca ccatcggatg catccttggc agcatgggct tagttgaaaa cttggggttg     4080

gttggcctcc tcttgttgac agcctcaaaa aagaggagtt ggcctccgag tgaggtgatg     4140

acggctgtcg gactgatctg tgcaattgtg ggcggactaa ccaagaccga cattgacatg     4200

gcgggaccca tggcagccat aggactgctg gtggtgagct atgtggtttc tggcaagagt     4260

gtggacatgt acattgaaaa ggtgtgtgac atatcatggg acaaggacgc tgaaataaca     4320

ggcacaagtc cgcggctgga tgtggctctc gacgacagtg gagatttctc acttatccag     4380

gatgacgggc cccccactcg agagattgtg ttgaaggtgt ttctgatgtg tgtttgcggt     4440

gtcagcccca tagccatccc ctttgcagcc gctgcttggt tcgtgtacat taaatcaggg     4500

aaaagaagcg gcgccatgtg ggacattcca tccccaagag aagtgaaaaa aggggaaaca     4560

acggctggag tgtacagaat catgacgcgt aaattgctgg gcagcacaca ggtgggagcc     4620

ggagtaatgc atgaaggtgt ttttcacaca atgtggcacg tcacaaaagg ttcggccctt     4680

cggagtggtg agggacgcct agatccatac tggggaaacg tgaagcagga tttgatctct     4740

tactgcggac catggaaact ggatgggaaa tgggacggcg tgtcggaagt ccaactgata     4800

gcggtcgccc caggtgagcg cgccagaaat gtgcagacaa aaccaggagt gttcaagacc     4860

actgatgggg aaatcggggc cttggccctt gacttcccag gcggaagttc aggctccccg     4920

ataattgaca aaaatggaca tgtaattggc ctgtatggaa atggtgtcgt ggtcaagagt     4980

ggaagctacg tgagtgccat catgcagaca gagaagatgg aggaacccgc agttgactgc     5040

tttgaggagg acatgctgag aaaaaagaag ctgacggtgc tcgacctcca tccaggagct     5100

ggaaaaactc gaagagtgct ccctcagatc gtcaaggctg caattaagaa acgcctacgc     5160

acggtaatcc tggcacccac ccgagtggtg gcagctgaga tggctgaggc actaaaagac     5220

cttccaataa ggtacatgac tccggcagtt tcagccaccc atgatggcaa tgagattgtt     5280

gaccttatgt gccacgccac ttttacatca aggctaatgc aaccaattag ggtgcctaat     5340

tacaatctat atataatgga tgaggcccac ttcacagatc ctgcaagcat cgctgcaaga     5400

gggtacatag caacaagagt ggacatggga gacgccgcgg ccatcttcat gacggccacc     5460

cctcctggca gcactgaagc tttcccggat tcaaacgccc ccatcacaga tgttgaaaca     5520

gaggttcctg acaaggcgtg gaattctgga tttgaatgga tcactgatta cccagggaaa     5580

accgtttggt ttgtccctag tgtcagaatg ggcaatgaga tctcggcctg cctcacaaaa     5640

gccggcaaat cggttatcca actcagccgg aaaacctttg aaacagagta ccagaagaca     5700

aagaatggtg agtgggactt tgtcgtgacc actgacatct cagaaatggg agccaacttc     5760

aaggccgaca gagtcataga ctcacggaaa tgcttgaagc cagtgattct ggatgacatg     5820

gaagagagag ttgttcttgc cgggccgatg gcagtaacac catccagcgc agctcaacgc     5880

agaggaagaa ttggaagaaa ccccaacaaa actggagatg agttctatta cggggggggc     5940

tgtgccgcaa cggatgatga ccatgctcat tgggtagagg ctaggatgct gcttgacaac     6000

atctacctcc aggacaacct cgttgcatct ctgtacaagc cagaacaagg aaaggtctcg     6060

gcaatagaag gggagttcaa actgagagga gaacagagga aaaccttcgt ggagctgatg     6120

aagagagggg acttgccagt gtggttgtca tatcaagtgg cggcctccgg actcagctat     6180

actgaccggc gctggtgctt tgatggaaaa aacaacaaca ccatcctgga ggactgcgtc     6240

cccgtcgagg tgtggacaaa atttggagag aaaaagattc tgaagcccag atggatggac     6300

gctcggatct gctctgatca tgcctctttg aagtctttca aggagtttgc tgcaggaaag     6360

agaacaatag ccactggctt aattgaggct tttgggatgc ttcccgggca catgactgag     6420

agattccagg aggccgtcga caatttggcc gtgttgatga gggccgaggc aggctctagg     6480

gcacacagaa tggctgcagc acagctccct gagacaatgg aaaccatcct gctcctcagc     6540

ctgctggcat tcgtgtcact tggtgtattt tttgtactga tgagggcaaa agggttagga     6600

aaaatggggt ccggcatgat cgtgctggca ggaagtggct ggctcatgtg gatgtctgag     6660

gtggaaccag cccgcatagc ttgtgtggtg atcatagtgt ttctgctaat ggtcgttctg     6720

attccggaac cggagaagca gcgctctccc caggacaatc agctggctct aattatcttg     6780

atcgcgacgg gcctcatcac gctcatcgcg gccaatgagc tgggttggtt agaaagaaca     6840

aagagtgacc tcaccaggct gttttggaga gaacacgctg agccaacagg agggagaggg     6900

ttttccttct cgctggacat tgacctgcgg ccggcatcgg cctgggcaat atatgccgct     6960

atgacaaccc tgatcacacc gacagtccaa cacgctgtga ccacatcgta caacaactac     7020

tctctcatgg ctatggccac tcaggccgga gttctttttg gcatgggacg gggggtgcct     7080

ttttacaaat gggactttgg cgtgccactc cttatgctgg gctgctactc acaacttacc     7140

ccactcaccc tgatcgtggc tctcgtgatg ctagccgctc actatctcta tctcatcccc     7200

gggctccagg caacggccgc cagggccgcc caacgaagga cggctgctgg aataatgaaa     7260

aacccagtgg tggatggaat tgtggtaact gacatagacc caatccaaat cgatccaaat     7320

gtcgaaaaga agatgggcca ggtcatgctc atctttgtgg ctttggcgag cgcggttctc     7380

atgagaacgg catggggttg gggagaggct ggtgcccttg catcggcagc agctgccacc     7440

ctatgggaag gggctcccaa caagtactgg aattcatcaa cggctacatc cttgtgcaac     7500

atatttcggg gaagttatct ggcaggtccc tccctcatct acaccgtcac acgcaatgca     7560

ggtatcatga agaaaagggg cggtggaaat ggagaaacgg tgggcgagaa atggaaggag     7620

cgcttgaatc ggatgaccgc gcttgaattc tacgcctaca agcggtcagg aataactgaa     7680

gtgtgcagag aacccgccag aagagccttg aaggatggag tcgtcacagg aggacacgct     7740

gtctcccgcg gaagcgcaaa gctgcgatgg atggtggaac gtggccacgt caatctagtg     7800

ggacgcgttg tcgacctcgg atgtggaagg ggtggctgga gttactacgc cgcatctcaa     7860

aagcaagtcc tcgaggtgag aggctacaca aaagggggag cgggccacga ggagcccatg     7920

aatgtccaaa gttatggttg gaacatagtg cgactcaaga gtggagtgga cgttttttat     7980

ctaccatcag aaccatgtga cacgctgctc tgtgacattg gagagtcatc ctcgagccca     8040

gcagtggaag aagcccggac tctgagagtg ctcgggatgg ttgaaacctg gctggaacgg     8100

ggcgtaaaga acttctgcat caaagtgctc tgcccgtaca ccagtgccat gattgagcgg     8160

ctggaagccc tccagcgtcg ctacggagga ggcctggtga gggttccact ctccagaaat     8220

tccacccacg aaatgtactg ggtctctgga gcaaaatcaa acatcatcag gagtgtgaat     8280

gccaccagcc agctgctcat gcacagaatg gacatcccca cgcggaaaac aaagtttgaa     8340

gaagacgtca atctggggac cggaaccagg gcagttgaaa gcagagctga ccctcccgac     8400

atgaaaaaac taggcagccg gattgagcgg ttgagaaagg aatatggatc cacttggcac     8460

tacgatgaaa accaccccta caggacatgg cattaccacg gcagttatga ggctgacacg     8520

caaggctccg cctcctcaat ggtcaacggc gtggtgcgtc tcctctcaaa accatgggat     8580

gcattgagct cggtcaccaa cattgctatg acggacacaa ctccgtttgg acagcagcgg     8640

gtgttcaagg agaaagtgga cacccggact ccagacccca agcagggcac gcaaagagtc     8700

atggccataa catcacaatg gctgtgggac cgcctagcaa gaaacaagac ccctcggatg     8760

tgcacgcgac aggaattcat aaacaaggtc aacagtcacg cggcgttggg acccgttttt     8820

agagaacagc agggatgggg ttcagcggcc gaagcggtgg tagatcctag gttttgggag     8880

ctcgttgaca atgaaagaga agcccatttg agaggggagt gcttgacctg tgtctacaac     8940

atgatgggga aaagagaaaa gaagctcggt gaattcggga aggcaaaagg cagcagagcc     9000

atttggtaca tgtggctggg agcccgcttc ctcgagttcg aggccctggg cttcctcaat     9060

gaagaccact ggttaagcag agagaactct ggagggggag ttgagggctt gggcctccaa     9120

aaacttggat acatccttga agagatcagc aggaggccag gaggcaaaat gtatgccgat     9180

gacacggctg gctgggacac ccgcatcacg aaatgcgacc tagaaaatga ggcgcgcatt     9240

ttggaaaaaa tggacgggat ccacaaaaaa ctcgcacggg ccgtcatcga gttgacatac     9300

aagcataagg ttgtgagagt cttgagacca gcaccacaag ggaaggtcgt tatggacatc     9360

atctccaggc cagaccaaag ggggagtggg caggtggtta cttatgccct caacacctat     9420

acaaacttgg tggtgcagct gatccgtaac atggaagcag aggctgtcat caatgaaaga     9480

gacatggagg agctccaaaa cccatggaaa gtcatcaatt ggctagaagg aaatggatgg     9540

gacagactcc gctcgatggc agtgagtgga gatgactgtg tcgtgaaacc aatggatgat     9600

aggttcgcct atgcactgaa tttcctcaat gacatgggca aggtcagaaa agatgtccag     9660

gaatggaagc cctcgccggg gtggacaaac tgggaagaag tgcccttttg ctcccaccac     9720

ttcaacaagc tcccgatgaa ggatggaaga acaataatag ttccctgccg gcaccaagat     9780

gagttgatag gcagggctag agtttctcca ggaaaaggct ggtcactcag tgaaacagca     9840

tgcttgggca agtcttatgc ccagatgtgg ctactgttgt actttcacag gagagatctc     9900

cgactcatgg caaacgcaat ctgctctgct gtaccggtga gttgggtgcc cacggggaga     9960

acaacctggt ccatccatgg gcgtggagag tggatgacaa cagaggacat gctagaggta    10020

tggaacagag tgtggatcat agagaatgag tacatggagg acaagacccc tgtcacagag    10080

tggaccgatg ttccatactt gggaaagaga gaagacttgt ggtgcggctc ccttattgga    10140

cacaggccaa gaagcacatg ggcagagaac atctgggctg ccatttatca agtgcgccga    10200

gcaatcggcg aaactgaaga atatagagac tacatgagca cacaggtccg ctatggctcg    10260

gaggaagggc caagcgctgg tgtgttgtaa                                     10290


<210>  88
<211>  3423
<212>  PRT
<213>  Zika virus isolate GD01 polyprotein

<400>  88

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Glu Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Gly Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Val  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  89
<211>  3423
<212>  PRT
<213>  Zika virus strain MRS_OPY_Martinique_PaRi_2015 polyprotein

<400>  89

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Glu Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Trp Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Thr Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Ala Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  90
<211>  3423
<212>  PRT
<213>  Zika virus strain H/PF/2013 polyprotein

<400>  90

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  91
<211>  3423
<212>  PRT
<213>  Zika virus strain MR 766 polyprotein

<400>  91

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly Tyr 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val Tyr  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Val Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Pro Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Ile Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Val Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Gly  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Leu  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Leu  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Ile Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Arg 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Thr Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu Tyr Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  92
<211>  3423
<212>  PRT
<213>  Zika virus strain 8375 polyprotein

<400>  92

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Ala Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Leu Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Arg Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Cys  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  93
<211>  3423
<212>  PRT
<213>  Zika virus strain 103344 polyprotein

<400>  93

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Ala Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Leu Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Arg Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Cys  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  94
<211>  3423
<212>  PRT
<213>  Zika virus strain ArD158084 polyprotein

<400>  94

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Arg Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Gly Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Val Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Leu Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Val Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Asn Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Gly  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Leu  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Arg 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Gln  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Thr Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Gly Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu Tyr Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  95
<211>  3423
<212>  PRT
<213>  Zika virus strain ArD157995 polyprotein


<220>
<221>  misc_feature
<222>  (904)..(904)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2829)..(2829)
<223>  Xaa can be any naturally occurring amino acid

<400>  95

Met Lys Asn Pro Lys Lys Lys Ser Gly Arg Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Thr Arg Arg Ser Arg Arg Ser Val Ser Leu Arg Tyr His Tyr Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Lys Lys His Leu Ile Met Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Ile Val Ser Val Ala Ile Thr Trp Leu Met Gly Ser Leu Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Val Leu Ile Val Pro Ala 
        275                 280                 285             


Tyr Ser Ile Ser Cys Ile Gly Val Ser Asn Arg Asp Leu Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Glu Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Met Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Leu Ser Asp Met Ala Ser Ala Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Pro Ser Leu Asp Lys Gln Ser Asp Thr Gln Ser Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Gly Asp Arg Gly Trp Gly Asn Gly Cys Gly Ile Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ser Lys Phe Thr Cys Cys Lys Lys Met Pro 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Pro 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Ser Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Xaa Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Val Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Leu Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Val Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Pro 
    1715                 1720                 1725             


Val Glu  Arg Ser Tyr Ser Arg  Trp Ser Leu Trp Pro  Ser Val Ala 
    1730                 1735                 1740             


Arg Thr  Gln Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Asn Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Ser  Gly Glu Glu Ser Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Met His Gly 
    2345                 2350                 2355             


Asp Leu  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Leu  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Xaa Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Arg 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ser Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Gln  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Thr Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu Tyr Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  96
<211>  3423
<212>  PRT
<213>  Zika virus strain ArD128000 polyprotein


<220>
<221>  misc_feature
<222>  (442)..(446)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Met Lys Asn Pro Lys Arg Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Xaa Xaa Xaa Xaa Xaa Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Arg Leu Val Arg Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp Leu Lys Lys Gly Ser Ser Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Ile Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Cys Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Arg Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val Tyr  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Val Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Glu  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Thr  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Ala  Ala Val Arg 
    1340                 1345                 1350             


Ile Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Thr  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Ala Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Arg Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Asn Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Ile Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Asp Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Ile Ala 
    2270                 2275                 2280             


Tyr Leu  Met Gly Arg Lys Glu  Glu Gly Thr Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Val Leu Leu  Arg Thr Ala Gly Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Glu Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Ile Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Ala Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


His Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Pro Lys Trp  Thr Glu Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Ser Leu Trp Cys Gly  Tyr Ile Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Leu 
    3380                 3385                 3390             


Arg Leu  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  97
<211>  3423
<212>  PRT
<213>  Zika virus strain ArD7117 polyprotein


<220>
<221>  misc_feature
<222>  (1437)..(1437)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1742)..(1742)
<223>  Xaa can be any naturally occurring amino acid

<400>  97

Met Lys Asn Pro Lys Lys Arg Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys Gln His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Val Cys Thr Ala Ala Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Ile Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Arg Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Val Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Val Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Glu  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Ile Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Xaa Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Ala Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Arg Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Leu Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Xaa Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Asn Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Ile Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Ser  Gly Glu Glu Ser Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Asp Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Lys Glu  Glu Gly Thr Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg His Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Arg  Arg Ile Glu Arg Ile  Arg Asn Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Ala Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


His Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Lys Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  98
<211>  3423
<212>  PRT
<213>  Zika virus strain ArB1362 polyprotein


<220>
<221>  misc_feature
<222>  (446)..(452)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1742)..(1742)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2983)..(2983)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Ile Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Asn Arg Ala Glu Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Arg Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Ala Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Val  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Met Thr  Ala Val Arg 
    1340                 1345                 1350             


Ile Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Xaa Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Asn Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Thr  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Pro Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Val Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Ile Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Lys  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Thr Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Xaa Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ser Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Ala Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Gly Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Lys Pro Glu Lys Val  Thr Arg Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala Cys 
    3185                 3190                 3195             


Cys Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Ser Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Met 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asp Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  99
<211>  3423
<212>  PRT
<213>  ZIKA VIRUS POLYPROTEIN GENBANK: EU545988.1


<220>
<221>  misc_feature
<222>  (845)..(845)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2121)..(2121)
<223>  Xaa can be any naturally occurring amino acid

<400>  99

Met Lys Asn Pro Lys Glu Glu Ile Arg Arg Ile Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Thr Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Val Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Ala Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Asp Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Xaa Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Ala Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Thr Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Pro Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Leu Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Lys Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Xaa Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Glu Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Ile Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp His 
    2420                 2425                 2430             


Arg Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Met Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  100
<211>  3423
<212>  PRT
<213>  Zika virus isolate Zika virus/H.sapiens-tc/PHL/2012/CPC-0740

<400>  100

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Val Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Val Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Ala Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Ile Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Thr Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Thr Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Met Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Ile Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Met Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Thr  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Pro Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Met Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  101
<211>  3423
<212>  PRT
<213>  Zika virus isolate Zika virus/H.sapiens-tc/THA/2014/SV0127- 14

<400>  101

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Thr Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Thr Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Gly Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Val Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Arg Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Met Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Val Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  102
<211>  3422
<212>  PRT
<213>  Zika virus isolate ARB7701 polyprotein


<220>
<221>  misc_feature
<222>  (1167)..(1167)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Asn Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Arg Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Ala Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Xaa Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Leu Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Ile Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Val Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Val Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Val Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Val Ile Gly Lys  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Ala Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Ala Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Lys Asn  Lys Val Val Lys Val  Leu Arg Pro Ala Glu  Gly Gly Lys 
    3095                 3100                 3105             


Thr Val  Met Asp Ile Ile Ser  Arg Gln Asp Gln Arg  Gly Ser Gly 
    3110                 3115                 3120             


Gln Val  Val Thr Tyr Ala Leu  Asn Thr Phe Thr Asn  Leu Val Val 
    3125                 3130                 3135             


Gln Leu  Ile Arg Asn Met Glu  Ala Glu Glu Val Leu  Glu Met Gln 
    3140                 3145                 3150             


Asp Leu  Trp Leu Leu Arg Lys  Pro Glu Lys Val Thr  Arg Trp Leu 
    3155                 3160                 3165             


Gln Cys  Asn Gly Trp Asp Arg  Leu Lys Arg Met Ala  Val Ser Gly 
    3170                 3175                 3180             


Asp Asp  Cys Val Val Lys Pro  Ile Asp Asp Arg Phe  Ala His Ala 
    3185                 3190                 3195             


Leu Arg  Phe Leu Asn Asp Met  Gly Lys Val Arg Lys  Asp Thr Gln 
    3200                 3205                 3210             


Glu Trp  Lys Pro Ser Thr Gly  Trp Ser Asn Trp Glu  Glu Val Pro 
    3215                 3220                 3225             


Phe Cys  Ser His His Phe Asn  Lys Leu His Leu Lys  Asp Gly Arg 
    3230                 3235                 3240             


Ser Ile  Val Val Pro Cys Arg  His Gln Asp Glu Leu  Ile Gly Arg 
    3245                 3250                 3255             


Ala Arg  Val Ser Pro Gly Ala  Gly Trp Ser Ile Arg  Glu Thr Ala 
    3260                 3265                 3270             


Cys Leu  Ala Lys Ser Tyr Ala  Gln Met Trp Gln Leu  Leu Tyr Phe 
    3275                 3280                 3285             


His Arg  Arg Asp Leu Arg Leu  Met Ala Asn Ala Ile  Cys Ser Ala 
    3290                 3295                 3300             


Val Pro  Val Asp Trp Val Pro  Thr Gly Arg Thr Thr  Trp Ser Ile 
    3305                 3310                 3315             


His Gly  Lys Gly Glu Trp Met  Thr Thr Glu Asp Met  Leu Met Val 
    3320                 3325                 3330             


Trp Asn  Arg Val Trp Ile Glu  Glu Asn Asp His Met  Glu Asp Lys 
    3335                 3340                 3345             


Thr Pro  Val Thr Lys Trp Thr  Asp Ile Pro Tyr Leu  Gly Lys Arg 
    3350                 3355                 3360             


Glu Asp  Leu Trp Cys Gly Ser  Leu Ile Gly His Arg  Pro Arg Thr 
    3365                 3370                 3375             


Thr Trp  Ala Glu Asn Ile Lys  Asp Thr Val Asn Met  Val Arg Arg 
    3380                 3385                 3390             


Ile Ile  Gly Asp Glu Glu Lys  Tyr Met Asp Tyr Leu  Ser Thr Gln 
    3395                 3400                 3405             


Val Arg  Tyr Leu Gly Glu Glu  Gly Ser Thr Pro Gly  Val Leu 
    3410                 3415                 3420         


<210>  103
<211>  3417
<212>  PRT
<213>  Zika virus isolate ARB15076 polyprotein

<400>  103

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Asn Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg 
        435                 440                 445             


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    450                 455                 460                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
465                 470                 475                 480 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                485                 490                 495     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            500                 505                 510         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        515                 520                 525             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    530                 535                 540                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
545                 550                 555                 560 


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
                565                 570                 575     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            580                 585                 590         


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
        595                 600                 605             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    610                 615                 620                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
625                 630                 635                 640 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                645                 650                 655     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            660                 665                 670         


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        675                 680                 685             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    690                 695                 700                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
705                 710                 715                 720 


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                725                 730                 735     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            740                 745                 750         


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        755                 760                 765             


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
    770                 775                 780                 


Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe Ser Lys Arg Glu 
785                 790                 795                 800 


Thr Arg Cys Gly Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp 
                805                 810                 815     


Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala 
            820                 825                 830         


Ala Val Lys Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser Ser Val 
        835                 840                 845             


Ser Arg Met Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu Leu Asn 
    850                 855                 860                 


Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser 
865                 870                 875                 880 


Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val 
                885                 890                 895     


Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val 
            900                 905                 910         


Arg Ala Ala Lys Thr Asn Asn Arg Phe Val Val Asp Gly Asp Thr Leu 
        915                 920                 925             


Lys Glu Cys Pro Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu 
    930                 935                 940                 


Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg 
945                 950                 955                 960 


Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val 
                965                 970                 975     


Lys Gly Lys Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile Glu Ser 
            980                 985                 990         


Glu Lys Asn Asp Thr Trp Arg Leu  Lys Arg Ala His Leu  Ile Glu Met 
        995                 1000                 1005             


Lys Thr  Cys Glu Trp Pro Lys  Ser His Thr Leu Trp  Thr Asp Gly 
    1010                 1015                 1020             


Val Glu  Glu Ser Asp Leu Ile  Ile Pro Lys Ser Leu  Ala Gly Pro 
    1025                 1030                 1035             


Leu Ser  His His Asn Thr Arg  Glu Gly Tyr Arg Thr  Gln Ala Lys 
    1040                 1045                 1050             


Gly Pro  Trp His Ser Glu Glu  Leu Glu Ile Arg Phe  Glu Glu Cys 
    1055                 1060                 1065             


Pro Gly  Thr Lys Val His Val  Glu Glu Thr Cys Gly  Thr Arg Gly 
    1070                 1075                 1080             


Pro Ser  Leu Arg Ser Thr Thr  Ala Ser Gly Arg Val  Ile Glu Glu 
    1085                 1090                 1095             


Trp Cys  Cys Arg Glu Cys Thr  Met Pro Pro Leu Ser  Phe Arg Ala 
    1100                 1105                 1110             


Lys Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Arg Lys Glu 
    1115                 1120                 1125             


Pro Glu  Ser Asn Leu Val Arg  Ser Met Val Thr Ala  Gly Ser Thr 
    1130                 1135                 1140             


Asp His  Met Asp His Phe Ser  Leu Gly Val Leu Val  Ile Leu Leu 
    1145                 1150                 1155             


Met Val  Gln Glu Gly Leu Lys  Lys Arg Met Thr Thr  Lys Ile Ile 
    1160                 1165                 1170             


Met Ser  Thr Ser Met Ala Val  Leu Val Ala Met Ile  Leu Gly Gly 
    1175                 1180                 1185             


Phe Ser  Met Ser Asp Leu Ala  Lys Leu Val Ile Leu  Met Gly Ala 
    1190                 1195                 1200             


Thr Phe  Ala Glu Met Asn Thr  Gly Gly Asp Val Ala  His Leu Ala 
    1205                 1210                 1215             


Leu Val  Ala Ala Phe Lys Val  Arg Pro Ala Leu Leu  Val Ser Phe 
    1220                 1225                 1230             


Ile Phe  Arg Ala Asn Trp Thr  Pro Arg Glu Ser Met  Leu Leu Ala 
    1235                 1240                 1245             


Leu Ala  Ser Cys Leu Leu Gln  Thr Ala Ile Ser Ala  Leu Glu Gly 
    1250                 1255                 1260             


Asp Leu  Met Val Leu Val Asn  Gly Phe Ala Leu Ala  Trp Leu Ala 
    1265                 1270                 1275             


Ile Arg  Ala Met Ala Val Pro  Arg Thr Asp Asn Ile  Ala Leu Ala 
    1280                 1285                 1290             


Val Leu  Ala Ala Leu Thr Pro  Leu Ala Arg Gly Thr  Leu Leu Val 
    1295                 1300                 1305             


Ala Trp  Arg Ala Gly Leu Ala  Thr Cys Gly Gly Phe  Met Leu Leu 
    1310                 1315                 1320             


Ser Leu  Lys Gly Lys Gly Ser  Val Lys Lys Asn Leu  Pro Phe Val 
    1325                 1330                 1335             


Met Ala  Leu Gly Leu Thr Ala  Val Arg Ile Val Asp  Pro Ile Asn 
    1340                 1345                 1350             


Val Val  Gly Leu Leu Leu Leu  Thr Arg Ser Gly Lys  Arg Ser Trp 
    1355                 1360                 1365             


Pro Pro  Ser Glu Val Leu Thr  Ala Val Gly Leu Ile  Cys Ala Leu 
    1370                 1375                 1380             


Ala Gly  Gly Phe Ala Lys Ala  Asp Ile Glu Met Ala  Gly Pro Met 
    1385                 1390                 1395             


Ala Ala  Val Gly Leu Leu Ile  Val Ser Tyr Val Val  Ser Gly Lys 
    1400                 1405                 1410             


Ser Val  Asp Met Tyr Ile Glu  Arg Ala Gly Asp Ile  Thr Trp Glu 
    1415                 1420                 1425             


Lys Asp  Ala Glu Val Thr Gly  Asn Ser Pro Arg Leu  Asp Val Ala 
    1430                 1435                 1440             


Leu Asp  Glu Ser Gly Asp Phe  Ser Leu Val Glu Glu  Asp Gly Pro 
    1445                 1450                 1455             


Pro Met  Arg Glu Ile Ile Leu  Lys Val Val Leu Met  Ala Ile Cys 
    1460                 1465                 1470             


Gly Met  Asn Pro Ile Ala Ile  Pro Phe Ala Ala Gly  Ala Trp Tyr 
    1475                 1480                 1485             


Val Tyr  Val Lys Thr Gly Lys  Arg Ser Gly Ala Leu  Trp Asp Val 
    1490                 1495                 1500             


Pro Ala  Pro Lys Glu Val Lys  Lys Gly Glu Thr Thr  Asp Gly Val 
    1505                 1510                 1515             


Tyr Arg  Val Met Thr Arg Arg  Leu Leu Gly Ser Thr  Gln Val Gly 
    1520                 1525                 1530             


Val Gly  Val Met Gln Glu Gly  Val Phe His Thr Met  Trp His Val 
    1535                 1540                 1545             


Thr Lys  Gly Ala Ala Leu Arg  Ser Gly Glu Gly Arg  Leu Asp Pro 
    1550                 1555                 1560             


Tyr Trp  Gly Asp Val Lys Gln  Asp Leu Val Ser Tyr  Cys Gly Pro 
    1565                 1570                 1575             


Trp Lys  Leu Asp Ala Ala Trp  Asp Gly Leu Ser Glu  Val Gln Leu 
    1580                 1585                 1590             


Leu Ala  Val Pro Pro Gly Glu  Arg Ala Arg Asn Ile  Gln Thr Leu 
    1595                 1600                 1605             


Pro Gly  Ile Phe Lys Thr Lys  Asp Gly Asp Ile Gly  Ala Val Ala 
    1610                 1615                 1620             


Leu Asp  Tyr Pro Ala Gly Thr  Ser Gly Ser Pro Ile  Leu Asp Lys 
    1625                 1630                 1635             


Cys Gly  Arg Val Ile Gly Leu  Tyr Gly Asn Gly Val  Val Ile Lys 
    1640                 1645                 1650             


Asn Gly  Ser Tyr Val Ser Ala  Ile Thr Gln Gly Lys  Arg Glu Glu 
    1655                 1660                 1665             


Glu Thr  Pro Val Glu Cys Phe  Glu Pro Ser Met Leu  Lys Lys Lys 
    1670                 1675                 1680             


Gln Leu  Thr Val Leu Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg 
    1685                 1690                 1695             


Arg Val  Leu Pro Glu Ile Val  Arg Glu Ala Ile Lys  Lys Arg Leu 
    1700                 1705                 1710             


Arg Thr  Val Ile Leu Ala Pro  Thr Arg Val Val Ala  Ala Glu Met 
    1715                 1720                 1725             


Glu Glu  Ala Leu Arg Gly Leu  Pro Val Arg Tyr Met  Thr Thr Ala 
    1730                 1735                 1740             


Val Asn  Val Thr His Ser Gly  Thr Glu Ile Val Asp  Leu Met Cys 
    1745                 1750                 1755             


His Ala  Thr Phe Thr Ser Arg  Leu Leu Gln Pro Ile  Arg Val Pro 
    1760                 1765                 1770             


Asn Tyr  Asn Leu Tyr Ile Met  Asp Glu Ala His Phe  Thr Asp Pro 
    1775                 1780                 1785             


Ser Ser  Ile Ala Ala Arg Gly  Tyr Ile Ser Thr Arg  Val Glu Met 
    1790                 1795                 1800             


Gly Glu  Ala Ala Ala Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr 
    1805                 1810                 1815             


Arg Asp  Ala Phe Pro Asp Ser  Asn Ser Pro Ile Met  Asp Thr Glu 
    1820                 1825                 1830             


Val Glu  Val Pro Glu Arg Ala  Trp Ser Ser Gly Phe  Asp Trp Val 
    1835                 1840                 1845             


Thr Asp  His Ser Gly Lys Thr  Val Trp Phe Val Pro  Ser Val Arg 
    1850                 1855                 1860             


Asn Gly  Asn Glu Ile Ala Ala  Cys Leu Thr Lys Ala  Gly Lys Arg 
    1865                 1870                 1875             


Val Ile  Gln Leu Ser Arg Lys  Thr Phe Glu Thr Glu  Phe Gln Lys 
    1880                 1885                 1890             


Thr Lys  Asn Gln Glu Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser 
    1895                 1900                 1905             


Glu Met  Gly Ala Asn Phe Lys  Ala Asp Arg Val Ile  Asp Ser Arg 
    1910                 1915                 1920             


Arg Cys  Leu Lys Pro Val Ile  Leu Asp Gly Glu Arg  Val Ile Leu 
    1925                 1930                 1935             


Ala Gly  Pro Met Pro Val Thr  His Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Asn Lys Pro Gly Asp  Glu Tyr Met 
    1955                 1960                 1965             


Tyr Gly  Gly Gly Cys Ala Glu  Thr Asp Glu Asp His  Ala His Trp 
    1970                 1975                 1980             


Leu Glu  Ala Arg Met Leu Leu  Asp Asn Ile Tyr Leu  Gln Asp Gly 
    1985                 1990                 1995             


Leu Ile  Ala Ser Leu Tyr Arg  Pro Glu Ala Asp Lys  Val Ala Ala 
    2000                 2005                 2010             


Ile Glu  Gly Glu Phe Lys Leu  Arg Thr Glu Gln Arg  Lys Thr Phe 
    2015                 2020                 2025             


Val Glu  Leu Met Lys Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Gln Val  Ala Ser Ala Gly Ile  Thr Tyr Thr Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Thr Thr Asn Asn  Thr Ile Met Glu Asp  Ser Val Pro 
    2060                 2065                 2070             


Ala Glu  Val Trp Thr Lys Tyr  Gly Glu Lys Arg Val  Leu Lys Pro 
    2075                 2080                 2085             


Arg Trp  Met Asp Ala Arg Val  Cys Ser Asp His Ala  Ala Leu Lys 
    2090                 2095                 2100             


Ser Phe  Lys Glu Phe Ala Ala  Gly Lys Arg Gly Ala  Ala Leu Gly 
    2105                 2110                 2115             


Val Met  Glu Ala Leu Gly Thr  Leu Pro Gly His Met  Thr Glu Arg 
    2120                 2125                 2130             


Phe Gln  Glu Ala Ile Asp Asn  Leu Ala Val Leu Met  Arg Ala Glu 
    2135                 2140                 2145             


Thr Gly  Ser Arg Pro Tyr Lys  Ala Ala Ala Ala Gln  Leu Pro Glu 
    2150                 2155                 2160             


Thr Leu  Glu Thr Ile Met Leu  Leu Gly Leu Leu Gly  Thr Val Ser 
    2165                 2170                 2175             


Leu Gly  Ile Phe Phe Val Leu  Met Arg Asn Lys Gly  Ile Gly Lys 
    2180                 2185                 2190             


Met Gly  Phe Gly Met Val Thr  Leu Gly Ala Ser Ala  Trp Leu Met 
    2195                 2200                 2205             


Trp Leu  Ser Glu Ile Glu Pro  Ala Arg Ile Ala Cys  Val Leu Ile 
    2210                 2215                 2220             


Val Val  Phe Leu Leu Leu Val  Val Leu Ile Pro Glu  Pro Glu Lys 
    2225                 2230                 2235             


Gln Arg  Ser Pro Gln Asp Asn  Gln Met Ala Ile Ile  Ile Met Val 
    2240                 2245                 2250             


Ala Val  Gly Leu Leu Gly Leu  Ile Thr Ala Asn Glu  Leu Gly Trp 
    2255                 2260                 2265             


Leu Glu  Arg Thr Lys Asn Asp  Ile Ala His Leu Met  Gly Arg Arg 
    2270                 2275                 2280             


Glu Glu  Gly Val Thr Met Gly  Phe Ser Met Asp Ile  Asp Leu Arg 
    2285                 2290                 2295             


Pro Ala  Ser Ala Trp Ala Ile  Tyr Ala Ala Leu Thr  Thr Leu Ile 
    2300                 2305                 2310             


Thr Pro  Ala Val Gln His Ala  Val Thr Thr Ser Tyr  Asn Asn Tyr 
    2315                 2320                 2325             


Ser Leu  Met Ala Met Ala Thr  Gln Ala Gly Val Leu  Phe Gly Met 
    2330                 2335                 2340             


Gly Lys  Gly Met Pro Phe Tyr  Ala Trp Asp Phe Gly  Val Pro Leu 
    2345                 2350                 2355             


Leu Met  Val Gly Cys Tyr Ser  Gln Leu Thr Pro Leu  Thr Leu Ile 
    2360                 2365                 2370             


Val Ala  Ile Ile Leu Leu Val  Ala His Tyr Met Tyr  Leu Ile Pro 
    2375                 2380                 2385             


Gly Leu  Gln Ala Ala Ala Ala  Arg Ala Ala Gln Lys  Arg Thr Ala 
    2390                 2395                 2400             


Ala Gly  Ile Met Lys Asn Pro  Val Val Asp Gly Ile  Val Val Thr 
    2405                 2410                 2415             


Asp Ile  Asp Thr Met Thr Ile  Asp Pro Gln Val Glu  Lys Lys Met 
    2420                 2425                 2430             


Gly Gln  Val Leu Leu Ile Ala  Val Ala Ile Ser Ser  Ala Val Leu 
    2435                 2440                 2445             


Leu Arg  Thr Ala Trp Gly Trp  Gly Glu Ala Gly Ala  Leu Ile Thr 
    2450                 2455                 2460             


Ala Ala  Thr Ser Thr Leu Trp  Glu Gly Ser Pro Asn  Lys Tyr Trp 
    2465                 2470                 2475             


Asn Ser  Ser Thr Ala Thr Ser  Leu Cys Asn Ile Phe  Arg Gly Ser 
    2480                 2485                 2490             


Tyr Leu  Ala Gly Ala Ser Leu  Ile Tyr Thr Val Thr  Arg Asn Ala 
    2495                 2500                 2505             


Gly Leu  Val Lys Arg Arg Gly  Gly Gly Thr Gly Glu  Thr Leu Gly 
    2510                 2515                 2520             


Glu Lys  Trp Lys Ala Arg Leu  Asn Gln Met Ser Ala  Leu Glu Phe 
    2525                 2530                 2535             


Tyr Ser  Tyr Lys Lys Ser Gly  Ile Thr Glu Val Cys  Arg Glu Glu 
    2540                 2545                 2550             


Ala Arg  Arg Ala Leu Lys Asn  Gly Val Ala Thr Gly  Gly His Ala 
    2555                 2560                 2565             


Val Ser  Arg Gly Ser Ala Lys  Leu Arg Trp Leu Val  Glu Arg Gly 
    2570                 2575                 2580             


Tyr Leu  Gln Pro His Gly Lys  Val Val Asp Leu Gly  Cys Gly Arg 
    2585                 2590                 2595             


Gly Gly  Trp Ser Tyr Tyr Ala  Ala Thr Ile Arg Lys  Val Gln Glu 
    2600                 2605                 2610             


Val Lys  Gly Tyr Thr Lys Gly  Gly Pro Gly His Glu  Glu Pro Met 
    2615                 2620                 2625             


Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Val Arg Leu  Lys Ser Gly 
    2630                 2635                 2640             


Val Asp  Val Phe His Met Ala  Ala Glu Pro Cys Asp  Thr Leu Leu 
    2645                 2650                 2655             


Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Pro Glu Val  Glu Glu Thr 
    2660                 2665                 2670             


Arg Thr  Leu Arg Val Leu Ser  Met Val Gly Asp Trp  Leu Glu Lys 
    2675                 2680                 2685             


Arg Pro  Gly Ala Phe Cys Ile  Lys Val Leu Cys Pro  Tyr Thr Ser 
    2690                 2695                 2700             


Thr Met  Met Glu Thr Met Glu  Arg Leu Gln Arg Arg  Tyr Gly Gly 
    2705                 2710                 2715             


Gly Leu  Val Arg Val Pro Leu  Ser Arg Asn Ser Thr  His Glu Met 
    2720                 2725                 2730             


Tyr Trp  Val Ser Gly Ala Lys  Ser Asn Ile Ile Lys  Ser Val Ser 
    2735                 2740                 2745             


Thr Thr  Ser Gln Leu Leu Leu  Gly Arg Met Asp Gly  Pro Arg Arg 
    2750                 2755                 2760             


Pro Val  Lys Tyr Glu Glu Asp  Val Asn Leu Gly Ser  Gly Thr Arg 
    2765                 2770                 2775             


Ala Val  Ala Ser Cys Ala Glu  Ala Pro Asn Met Lys  Ile Ile Gly 
    2780                 2785                 2790             


Lys Arg  Ile Glu Arg Ile Arg  Ser Glu His Ala Glu  Thr Trp Phe 
    2795                 2800                 2805             


Phe Asp  Glu Asn His Pro Tyr  Arg Thr Trp Ala Tyr  His Gly Ser 
    2810                 2815                 2820             


Tyr Glu  Ala Pro Thr Gln Gly  Ser Ala Ser Ser Leu  Val Asn Gly 
    2825                 2830                 2835             


Val Val  Arg Leu Leu Ser Lys  Pro Trp Asp Val Val  Thr Gly Val 
    2840                 2845                 2850             


Thr Gly  Ile Ala Met Thr Asp  Thr Thr Pro Tyr Gly  Gln Gln Arg 
    2855                 2860                 2865             


Val Phe  Lys Glu Lys Val Asp  Thr Arg Val Pro Asp  Pro Gln Glu 
    2870                 2875                 2880             


Gly Thr  Arg Gln Thr Met Asn  Met Val Ser Ser Trp  Leu Trp Lys 
    2885                 2890                 2895             


Glu Leu  Gly Lys Arg Lys Arg  Pro Arg Val Cys Thr  Lys Glu Glu 
    2900                 2905                 2910             


Phe Ile  Asn Lys Val Arg Ser  Asn Ala Ala Leu Gly  Ala Ile Phe 
    2915                 2920                 2925             


Glu Glu  Glu Lys Glu Trp Lys  Thr Ala Val Glu Ala  Val Asn Asp 
    2930                 2935                 2940             


Pro Arg  Phe Trp Ala Leu Val  Asp Lys Glu Arg Glu  His His Leu 
    2945                 2950                 2955             


Arg Gly  Glu Cys His Ser Cys  Val Tyr Asn Met Met  Gly Lys Arg 
    2960                 2965                 2970             


Glu Lys  Lys Gln Gly Glu Phe  Gly Lys Ala Lys Gly  Ser Arg Ala 
    2975                 2980                 2985             


Ile Trp  Tyr Met Trp Leu Gly  Ala Arg Phe Leu Glu  Phe Glu Ala 
    2990                 2995                 3000             


Leu Gly  Phe Leu Asn Glu Asp  His Trp Met Gly Arg  Glu Asn Ser 
    3005                 3010                 3015             


Gly Gly  Gly Val Glu Gly Leu  Gly Leu Gln Arg Leu  Gly Tyr Ile 
    3020                 3025                 3030             


Leu Glu  Glu Met Asn Arg Ala  Pro Gly Gly Lys Met  Tyr Ala Asp 
    3035                 3040                 3045             


Asp Thr  Ala Gly Trp Asp Thr  Arg Ile Ser Lys Phe  Asp Leu Glu 
    3050                 3055                 3060             


Asn Glu  Ala Leu Ile Thr Asn  Gln Met Glu Glu Gly  His Arg Ala 
    3065                 3070                 3075             


Leu Ala  Leu Ala Val Ile Lys  Tyr Thr Tyr Gln Asn  Lys Val Val 
    3080                 3085                 3090             


Lys Val  Leu Arg Pro Ala Glu  Gly Gly Lys Thr Val  Met Asp Ile 
    3095                 3100                 3105             


Ile Ser  Arg Gln Asp Gln Arg  Gly Ser Gly Gln Val  Val Thr Tyr 
    3110                 3115                 3120             


Ala Leu  Asn Thr Phe Thr Asn  Leu Val Val Gln Leu  Ile Arg Asn 
    3125                 3130                 3135             


Met Glu  Ala Glu Glu Val Leu  Glu Met Gln Asp Leu  Trp Leu Leu 
    3140                 3145                 3150             


Arg Lys  Pro Glu Lys Val Thr  Arg Trp Leu Gln Cys  Asn Gly Trp 
    3155                 3160                 3165             


Asp Arg  Leu Lys Arg Met Ala  Val Ser Gly Asp Asp  Cys Val Val 
    3170                 3175                 3180             


Lys Pro  Ile Asp Asp Arg Phe  Ala His Ala Leu Arg  Phe Leu Asn 
    3185                 3190                 3195             


Asp Met  Gly Lys Val Arg Lys  Asp Thr Gln Glu Trp  Lys Pro Ser 
    3200                 3205                 3210             


Thr Gly  Trp Ser Asn Trp Glu  Glu Val Pro Phe Cys  Ser His His 
    3215                 3220                 3225             


Phe Asn  Lys Leu His Leu Lys  Asp Gly Arg Ser Ile  Val Val Pro 
    3230                 3235                 3240             


Cys Arg  His Gln Asp Glu Leu  Ile Gly Arg Ala Arg  Val Ser Pro 
    3245                 3250                 3255             


Gly Ala  Gly Trp Ser Ile Arg  Glu Thr Ala Cys Leu  Ala Lys Ser 
    3260                 3265                 3270             


Tyr Ala  Gln Met Trp Gln Leu  Leu Tyr Phe His Arg  Arg Asp Leu 
    3275                 3280                 3285             


Arg Leu  Met Ala Asn Ala Ile  Cys Ser Ala Val Pro  Val Asp Trp 
    3290                 3295                 3300             


Val Pro  Thr Gly Arg Thr Thr  Trp Ser Ile His Gly  Lys Gly Glu 
    3305                 3310                 3315             


Trp Met  Thr Thr Glu Asp Met  Leu Met Val Trp Asn  Arg Val Trp 
    3320                 3325                 3330             


Ile Glu  Glu Asn Asp His Met  Glu Asp Lys Thr Pro  Val Thr Lys 
    3335                 3340                 3345             


Trp Thr  Asp Ile Pro Tyr Leu  Gly Lys Arg Glu Asp  Leu Trp Cys 
    3350                 3355                 3360             


Gly Ser  Leu Ile Gly His Arg  Pro Arg Thr Thr Trp  Ala Glu Asn 
    3365                 3370                 3375             


Ile Lys  Asp Thr Val Asn Met  Val Arg Arg Ile Ile  Gly Asp Glu 
    3380                 3385                 3390             


Glu Lys  Tyr Met Asp Tyr Leu  Ser Thr Gln Val Arg  Tyr Leu Gly 
    3395                 3400                 3405             


Glu Glu  Gly Ser Thr Pro Gly  Val Leu 
    3410                 3415         


<210>  104
<211>  3422
<212>  PRT
<213>  Zika virus isolate ARB13565 polyprotein

<400>  104

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Asn Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Arg Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Ala Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Met  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Leu Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Val Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Val  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Ala Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Ala Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Ile Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Glu Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Ala Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ala Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


Leu Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Lys Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys Asn Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Met Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Lys  Tyr Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Val Ala Leu Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Asn  Asp Ile Ala 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Val Thr Met  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Leu Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Met Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Ile Ser  Ser Ala Val Leu Leu  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro His Gly  Lys Val Val 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Thr Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Met  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Val Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Ala Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Val Ile Gly Lys  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Ala Met  Asn Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys Arg Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys His Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Ile Leu  Glu Glu Met Asn Arg  Ala Pro Gly 
    3035                 3040                 3045             


Gly Lys  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Lys  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Glu  Gly His Arg Ala Leu  Ala Leu Ala Val Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Lys Asn  Lys Val Val Lys Val  Leu Arg Pro Ala Glu  Gly Gly Lys 
    3095                 3100                 3105             


Thr Val  Met Asp Ile Ile Ser  Arg Gln Asp Gln Arg  Gly Ser Gly 
    3110                 3115                 3120             


Gln Val  Val Thr Tyr Ala Leu  Asn Thr Phe Thr Asn  Leu Val Val 
    3125                 3130                 3135             


Gln Leu  Ile Arg Asn Met Glu  Ala Glu Glu Val Leu  Glu Met Gln 
    3140                 3145                 3150             


Asp Leu  Trp Leu Leu Arg Lys  Pro Glu Lys Val Thr  Arg Trp Leu 
    3155                 3160                 3165             


Gln Cys  Asn Gly Trp Asp Arg  Leu Lys Arg Met Ala  Val Ser Gly 
    3170                 3175                 3180             


Asp Asp  Cys Val Val Lys Pro  Ile Asp Asp Arg Phe  Ala His Ala 
    3185                 3190                 3195             


Leu Arg  Phe Leu Asn Asp Met  Gly Lys Val Arg Lys  Asp Thr Gln 
    3200                 3205                 3210             


Glu Trp  Lys Pro Ser Thr Gly  Trp Ser Asn Trp Glu  Glu Val Pro 
    3215                 3220                 3225             


Phe Cys  Ser His His Phe Asn  Lys Leu His Leu Lys  Asp Gly Arg 
    3230                 3235                 3240             


Ser Ile  Val Val Pro Cys Arg  His Gln Asp Glu Leu  Ile Gly Arg 
    3245                 3250                 3255             


Ala Arg  Val Ser Pro Gly Ala  Gly Trp Ser Ile Arg  Glu Thr Ala 
    3260                 3265                 3270             


Cys Leu  Ala Lys Ser Tyr Ala  Gln Met Trp Gln Leu  Leu Tyr Phe 
    3275                 3280                 3285             


His Arg  Arg Asp Leu Arg Leu  Met Ala Asn Ala Ile  Cys Ser Ala 
    3290                 3295                 3300             


Val Pro  Val Asp Trp Val Pro  Thr Gly Arg Thr Thr  Trp Ser Ile 
    3305                 3310                 3315             


His Gly  Lys Gly Glu Trp Met  Thr Thr Glu Asp Met  Leu Met Val 
    3320                 3325                 3330             


Trp Asn  Arg Val Trp Ile Glu  Glu Asn Asp His Met  Glu Asp Lys 
    3335                 3340                 3345             


Thr Pro  Val Thr Lys Trp Thr  Asp Ile Pro Tyr Leu  Gly Lys Arg 
    3350                 3355                 3360             


Glu Asp  Leu Trp Cys Gly Ser  Leu Ile Gly His Arg  Pro Arg Thr 
    3365                 3370                 3375             


Thr Trp  Ala Glu Asn Ile Lys  Asp Thr Val Asn Met  Val Arg Arg 
    3380                 3385                 3390             


Ile Ile  Gly Asp Glu Glu Lys  Tyr Met Asp Tyr Leu  Ser Thr Gln 
    3395                 3400                 3405             


Val Arg  Tyr Leu Gly Glu Glu  Gly Ser Thr Pro Gly  Val Leu 
    3410                 3415                 3420         


<210>  105
<211>  3417
<212>  PRT
<213>  Zika virus strain MR 766 polyprotein

<400>  105

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Thr Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Thr Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg 
        435                 440                 445             


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    450                 455                 460                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
465                 470                 475                 480 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                485                 490                 495     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            500                 505                 510         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        515                 520                 525             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    530                 535                 540                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
545                 550                 555                 560 


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
                565                 570                 575     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            580                 585                 590         


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
        595                 600                 605             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    610                 615                 620                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
625                 630                 635                 640 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                645                 650                 655     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            660                 665                 670         


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        675                 680                 685             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    690                 695                 700                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
705                 710                 715                 720 


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                725                 730                 735     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            740                 745                 750         


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        755                 760                 765             


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
    770                 775                 780                 


Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu 
785                 790                 795                 800 


Thr Arg Cys Gly Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp 
                805                 810                 815     


Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala 
            820                 825                 830         


Ala Val Lys Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser Ser Val 
        835                 840                 845             


Ser Arg Met Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu Leu Asn 
    850                 855                 860                 


Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser 
865                 870                 875                 880 


Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val 
                885                 890                 895     


Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val 
            900                 905                 910         


Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu 
        915                 920                 925             


Lys Glu Cys Pro Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu 
    930                 935                 940                 


Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg 
945                 950                 955                 960 


Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val 
                965                 970                 975     


Lys Gly Lys Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile Glu Ser 
            980                 985                 990         


Glu Lys Asn Asp Thr Trp Arg Leu  Lys Arg Ala His Leu  Ile Glu Met 
        995                 1000                 1005             


Lys Thr  Cys Glu Trp Pro Lys  Ser His Thr Leu Trp  Thr Asp Gly 
    1010                 1015                 1020             


Val Glu  Glu Ser Asp Leu Ile  Ile Pro Lys Ser Leu  Ala Gly Pro 
    1025                 1030                 1035             


Leu Ser  His His Asn Thr Arg  Glu Gly Tyr Arg Thr  Gln Val Lys 
    1040                 1045                 1050             


Gly Pro  Trp His Ser Glu Glu  Leu Glu Ile Arg Phe  Glu Glu Cys 
    1055                 1060                 1065             


Pro Gly  Thr Lys Val His Val  Glu Glu Thr Cys Gly  Thr Arg Gly 
    1070                 1075                 1080             


Pro Ser  Leu Arg Ser Thr Thr  Ala Ser Gly Arg Val  Ile Glu Glu 
    1085                 1090                 1095             


Trp Cys  Cys Arg Glu Cys Thr  Met Pro Pro Leu Ser  Phe Arg Ala 
    1100                 1105                 1110             


Lys Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Arg Lys Glu 
    1115                 1120                 1125             


Pro Glu  Ser Asn Leu Val Arg  Ser Met Val Thr Ala  Gly Ser Thr 
    1130                 1135                 1140             


Asp His  Met Asp His Phe Ser  Leu Gly Val Leu Val  Ile Leu Leu 
    1145                 1150                 1155             


Met Val  Gln Glu Gly Leu Lys  Lys Arg Met Thr Thr  Lys Ile Ile 
    1160                 1165                 1170             


Met Ser  Thr Ser Met Ala Val  Leu Val Ala Met Ile  Leu Gly Gly 
    1175                 1180                 1185             


Phe Ser  Met Ser Asp Leu Ala  Lys Leu Val Ile Leu  Met Gly Ala 
    1190                 1195                 1200             


Thr Phe  Ala Glu Met Asn Thr  Gly Gly Asp Val Ala  His Leu Ala 
    1205                 1210                 1215             


Leu Val  Ala Ala Phe Lys Val  Arg Pro Ala Leu Leu  Val Ser Phe 
    1220                 1225                 1230             


Ile Phe  Arg Ala Asn Trp Thr  Pro Arg Glu Ser Met  Leu Leu Ala 
    1235                 1240                 1245             


Leu Ala  Ser Cys Leu Leu Gln  Thr Ala Ile Ser Ala  Leu Glu Gly 
    1250                 1255                 1260             


Asp Leu  Met Val Leu Val Asn  Gly Phe Ala Leu Ala  Trp Leu Ala 
    1265                 1270                 1275             


Ile Arg  Ala Met Ala Val Pro  Arg Thr Asp Asn Ile  Ala Leu Ala 
    1280                 1285                 1290             


Ile Leu  Ala Ala Leu Thr Pro  Leu Ala Arg Gly Thr  Leu Leu Val 
    1295                 1300                 1305             


Ala Trp  Arg Ala Gly Leu Ala  Thr Cys Gly Gly Phe  Met Leu Leu 
    1310                 1315                 1320             


Ser Leu  Lys Gly Lys Gly Ser  Val Lys Lys Asn Leu  Pro Phe Val 
    1325                 1330                 1335             


Ala Ala  Leu Gly Leu Thr Ala  Val Arg Ile Val Asp  Pro Ile Asn 
    1340                 1345                 1350             


Val Val  Gly Leu Leu Leu Leu  Thr Arg Ser Gly Lys  Arg Ser Trp 
    1355                 1360                 1365             


Pro Pro  Ser Glu Val Leu Thr  Ala Val Gly Leu Ile  Cys Ala Leu 
    1370                 1375                 1380             


Ala Gly  Gly Phe Ala Lys Ala  Asp Ile Glu Met Ala  Gly Pro Met 
    1385                 1390                 1395             


Ala Ala  Val Gly Leu Leu Ile  Val Ser Tyr Val Val  Ser Gly Lys 
    1400                 1405                 1410             


Ser Val  Asp Met Tyr Ile Glu  Arg Ala Gly Asp Ile  Thr Trp Glu 
    1415                 1420                 1425             


Lys Asp  Ala Glu Val Thr Gly  Asn Ser Pro Arg Leu  Asp Val Ala 
    1430                 1435                 1440             


Leu Asp  Glu Ser Gly Asp Phe  Ser Leu Val Glu Glu  Asp Gly Pro 
    1445                 1450                 1455             


Pro Met  Arg Glu Ile Ile Leu  Lys Val Val Leu Met  Ala Ile Cys 
    1460                 1465                 1470             


Gly Met  Asn Pro Ile Ala Ile  Pro Phe Ala Ala Gly  Ala Trp Tyr 
    1475                 1480                 1485             


Val Tyr  Val Lys Thr Gly Lys  Arg Ser Gly Ala Leu  Trp Asp Val 
    1490                 1495                 1500             


Pro Ala  Pro Lys Glu Val Lys  Lys Gly Glu Thr Thr  Asp Gly Val 
    1505                 1510                 1515             


Tyr Arg  Val Met Thr Arg Arg  Leu Leu Gly Ser Thr  Gln Val Gly 
    1520                 1525                 1530             


Val Gly  Val Met Gln Glu Gly  Val Phe His Thr Met  Trp His Val 
    1535                 1540                 1545             


Thr Lys  Gly Ala Ala Leu Arg  Ser Gly Glu Gly Arg  Leu Asp Pro 
    1550                 1555                 1560             


Tyr Trp  Gly Asp Val Lys Gln  Asp Leu Val Ser Tyr  Cys Gly Pro 
    1565                 1570                 1575             


Trp Lys  Leu Asp Ala Ala Trp  Asp Gly Val Ser Glu  Val Gln Leu 
    1580                 1585                 1590             


Leu Ala  Val Pro Pro Gly Glu  Arg Ala Arg Asn Ile  Gln Thr Leu 
    1595                 1600                 1605             


Pro Gly  Ile Phe Lys Thr Lys  Asp Gly Asp Ile Gly  Ala Val Ala 
    1610                 1615                 1620             


Leu Asp  Tyr Pro Ala Gly Thr  Ser Gly Ser Pro Ile  Leu Asp Lys 
    1625                 1630                 1635             


Cys Gly  Arg Val Ile Gly Leu  Tyr Gly Asn Gly Val  Val Ile Lys 
    1640                 1645                 1650             


Asn Gly  Ser Tyr Val Ser Ala  Ile Thr Gln Gly Lys  Arg Glu Glu 
    1655                 1660                 1665             


Glu Thr  Pro Val Glu Cys Phe  Glu Pro Ser Met Leu  Lys Lys Lys 
    1670                 1675                 1680             


Gln Leu  Thr Val Leu Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg 
    1685                 1690                 1695             


Arg Val  Leu Pro Glu Ile Val  Arg Glu Ala Ile Lys  Lys Arg Leu 
    1700                 1705                 1710             


Arg Thr  Val Ile Leu Ala Pro  Thr Arg Val Val Ala  Ala Glu Met 
    1715                 1720                 1725             


Glu Glu  Ala Leu Arg Gly Leu  Pro Val Arg Tyr Met  Thr Thr Ala 
    1730                 1735                 1740             


Val Lys  Val Thr His Ser Gly  Thr Glu Ile Val Asp  Leu Met Cys 
    1745                 1750                 1755             


His Ala  Thr Phe Thr Ser Arg  Leu Leu Gln Pro Ile  Arg Val Pro 
    1760                 1765                 1770             


Asn Tyr  Asn Leu Tyr Ile Met  Asp Glu Ala His Phe  Thr Asp Pro 
    1775                 1780                 1785             


Ser Ser  Ile Ala Ala Arg Gly  Tyr Ile Ser Thr Arg  Val Glu Met 
    1790                 1795                 1800             


Gly Glu  Ala Ala Ala Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr 
    1805                 1810                 1815             


Arg Asp  Ala Phe Pro Asp Ser  Asn Ser Pro Ile Met  Asp Thr Glu 
    1820                 1825                 1830             


Val Glu  Val Pro Glu Arg Ala  Trp Ser Ser Gly Phe  Asp Trp Val 
    1835                 1840                 1845             


Thr Asp  His Ser Gly Lys Thr  Val Trp Phe Val Pro  Ser Val Arg 
    1850                 1855                 1860             


Asn Gly  Asn Glu Ile Ala Ala  Cys Leu Thr Lys Ala  Gly Lys Arg 
    1865                 1870                 1875             


Val Ile  Gln Leu Ser Arg Lys  Thr Phe Glu Thr Glu  Phe Gln Lys 
    1880                 1885                 1890             


Thr Lys  Asn Gln Glu Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser 
    1895                 1900                 1905             


Glu Met  Gly Ala Asn Phe Lys  Ala Asp Arg Val Ile  Asp Ser Arg 
    1910                 1915                 1920             


Arg Cys  Leu Lys Pro Val Ile  Leu Asp Gly Glu Arg  Val Ile Leu 
    1925                 1930                 1935             


Ala Gly  Pro Met Pro Val Thr  His Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Asn Lys Pro Gly Asp  Glu Tyr Met 
    1955                 1960                 1965             


Tyr Gly  Gly Gly Cys Ala Glu  Thr Asp Glu Asp His  Ala His Trp 
    1970                 1975                 1980             


Leu Glu  Ala Arg Met Leu Leu  Asp Asn Ile Tyr Leu  Gln Asp Gly 
    1985                 1990                 1995             


Leu Ile  Ala Ser Leu Tyr Arg  Pro Glu Ala Asp Lys  Val Ala Ala 
    2000                 2005                 2010             


Ile Glu  Gly Glu Phe Lys Leu  Arg Thr Glu Gln Arg  Lys Thr Phe 
    2015                 2020                 2025             


Val Glu  Leu Met Lys Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Gln Val  Ala Ser Ala Gly Ile  Thr Tyr Thr Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Thr Thr Asn Asn  Thr Ile Met Glu Asp  Ser Val Pro 
    2060                 2065                 2070             


Ala Glu  Val Trp Thr Lys Tyr  Gly Glu Lys Arg Val  Leu Lys Pro 
    2075                 2080                 2085             


Arg Trp  Met Asp Ala Arg Val  Cys Ser Asp His Ala  Ala Leu Lys 
    2090                 2095                 2100             


Ser Phe  Lys Glu Phe Ala Ala  Gly Lys Arg Gly Ala  Ala Leu Gly 
    2105                 2110                 2115             


Val Met  Glu Ala Leu Gly Thr  Leu Pro Gly His Met  Thr Glu Arg 
    2120                 2125                 2130             


Phe Gln  Glu Ala Ile Asp Asn  Leu Ala Val Leu Met  Arg Ala Glu 
    2135                 2140                 2145             


Thr Gly  Ser Arg Pro Tyr Lys  Ala Ala Ala Ala Gln  Leu Pro Glu 
    2150                 2155                 2160             


Thr Leu  Glu Thr Ile Met Leu  Leu Gly Leu Leu Gly  Thr Val Ser 
    2165                 2170                 2175             


Leu Gly  Ile Phe Phe Val Leu  Met Arg Asn Lys Gly  Ile Gly Lys 
    2180                 2185                 2190             


Met Gly  Phe Glu Met Val Thr  Leu Gly Ala Ser Ala  Trp Leu Met 
    2195                 2200                 2205             


Trp Leu  Ser Glu Ile Glu Pro  Ala Arg Ile Ala Cys  Val Leu Ile 
    2210                 2215                 2220             


Val Val  Phe Leu Leu Leu Val  Val Leu Ile Pro Glu  Pro Glu Lys 
    2225                 2230                 2235             


Gln Arg  Ser Pro Gln Asp Asn  Gln Met Ala Ile Ile  Ile Met Val 
    2240                 2245                 2250             


Ala Val  Gly Leu Leu Gly Leu  Ile Thr Ala Asn Glu  Leu Gly Trp 
    2255                 2260                 2265             


Leu Glu  Arg Thr Lys Asn Asp  Ile Ala His Leu Met  Gly Lys Arg 
    2270                 2275                 2280             


Glu Glu  Gly Thr Thr Val Gly  Phe Ser Met Asp Ile  Asp Leu Arg 
    2285                 2290                 2295             


Pro Ala  Ser Ala Trp Ala Ile  Tyr Ala Ala Leu Thr  Thr Leu Ile 
    2300                 2305                 2310             


Thr Pro  Ala Val Gln His Ala  Val Thr Thr Ser Tyr  Asn Asn Tyr 
    2315                 2320                 2325             


Ser Leu  Met Ala Met Ala Thr  Gln Ala Gly Val Leu  Phe Gly Met 
    2330                 2335                 2340             


Gly Lys  Gly Met Pro Phe Tyr  Ala Trp Asp Leu Gly  Val Pro Leu 
    2345                 2350                 2355             


Leu Met  Met Gly Cys Tyr Ser  Gln Leu Thr Pro Leu  Thr Leu Ile 
    2360                 2365                 2370             


Val Ala  Ile Ile Leu Leu Val  Ala His Tyr Met Tyr  Leu Ile Pro 
    2375                 2380                 2385             


Gly Leu  Gln Ala Ala Ala Ala  Arg Ala Ala Gln Lys  Arg Thr Ala 
    2390                 2395                 2400             


Ala Gly  Ile Met Lys Asn Pro  Val Val Asp Gly Ile  Val Val Thr 
    2405                 2410                 2415             


Asp Ile  Asp Thr Met Thr Ile  Asp Pro Gln Val Glu  Lys Lys Met 
    2420                 2425                 2430             


Gly Gln  Val Leu Leu Ile Ala  Val Ala Val Ser Ser  Ala Val Leu 
    2435                 2440                 2445             


Leu Arg  Thr Ala Trp Gly Trp  Gly Glu Ala Gly Ala  Leu Ile Thr 
    2450                 2455                 2460             


Ala Ala  Thr Ser Thr Leu Trp  Glu Gly Ser Pro Asn  Lys Tyr Trp 
    2465                 2470                 2475             


Asn Ser  Ser Thr Ala Thr Ser  Leu Cys Asn Ile Phe  Arg Gly Ser 
    2480                 2485                 2490             


Tyr Leu  Ala Gly Ala Ser Leu  Ile Tyr Thr Val Thr  Arg Asn Ala 
    2495                 2500                 2505             


Gly Leu  Val Lys Arg Arg Gly  Gly Gly Thr Gly Glu  Thr Leu Gly 
    2510                 2515                 2520             


Glu Lys  Trp Lys Ala Arg Leu  Asn Gln Met Ser Ala  Leu Glu Phe 
    2525                 2530                 2535             


Tyr Ser  Tyr Lys Lys Ser Gly  Ile Thr Glu Val Cys  Arg Glu Glu 
    2540                 2545                 2550             


Ala Arg  Arg Ala Leu Lys Asp  Gly Val Ala Thr Gly  Gly His Ala 
    2555                 2560                 2565             


Val Ser  Arg Gly Ser Ala Lys  Leu Arg Trp Leu Val  Glu Arg Gly 
    2570                 2575                 2580             


Tyr Leu  Gln Pro Tyr Gly Lys  Val Val Asp Leu Gly  Cys Gly Arg 
    2585                 2590                 2595             


Gly Gly  Trp Ser Tyr Tyr Ala  Ala Thr Ile Arg Lys  Val Gln Glu 
    2600                 2605                 2610             


Val Arg  Gly Tyr Thr Lys Gly  Gly Pro Gly His Glu  Glu Pro Met 
    2615                 2620                 2625             


Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Ile Arg Leu  Lys Ser Gly 
    2630                 2635                 2640             


Val Asp  Val Phe His Met Ala  Ala Glu Ser Cys Asp  Thr Leu Leu 
    2645                 2650                 2655             


Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Pro Glu Val  Glu Glu Thr 
    2660                 2665                 2670             


Arg Thr  Leu Arg Val Leu Ser  Met Val Gly Asp Trp  Leu Glu Lys 
    2675                 2680                 2685             


Arg Pro  Gly Ala Phe Cys Ile  Lys Val Leu Cys Pro  Tyr Thr Ser 
    2690                 2695                 2700             


Thr Met  Met Glu Thr Met Glu  Arg Leu Gln Arg Arg  Tyr Gly Gly 
    2705                 2710                 2715             


Gly Leu  Val Arg Val Pro Leu  Ser Arg Asn Ser Thr  His Glu Met 
    2720                 2725                 2730             


Tyr Trp  Val Ser Gly Ala Lys  Ser Asn Ile Ile Lys  Ser Val Ser 
    2735                 2740                 2745             


Thr Thr  Ser Gln Leu Leu Leu  Gly Arg Met Asp Gly  Pro Arg Arg 
    2750                 2755                 2760             


Pro Val  Lys Tyr Glu Glu Asp  Val Asn Leu Gly Ser  Gly Thr Arg 
    2765                 2770                 2775             


Ala Val  Ala Ser Cys Ala Glu  Ala Pro Asn Met Lys  Val Ile Gly 
    2780                 2785                 2790             


Arg Arg  Ile Glu Arg Ile Arg  Ser Glu His Ala Glu  Thr Trp Phe 
    2795                 2800                 2805             


Phe Asp  Glu Asn His Pro Tyr  Arg Thr Trp Ala Tyr  His Gly Ser 
    2810                 2815                 2820             


Tyr Glu  Ala Pro Thr Gln Gly  Ser Ala Ser Ser Leu  Val Asn Gly 
    2825                 2830                 2835             


Val Val  Arg Leu Leu Ser Lys  Pro Trp Asp Val Val  Thr Gly Val 
    2840                 2845                 2850             


Thr Gly  Ile Ala Met Thr Asp  Thr Thr Pro Tyr Gly  Gln Gln Arg 
    2855                 2860                 2865             


Val Phe  Lys Glu Lys Val Asp  Thr Arg Val Pro Asp  Pro Gln Glu 
    2870                 2875                 2880             


Gly Thr  Arg Gln Val Met Asn  Met Val Ala Ser Trp  Leu Trp Lys 
    2885                 2890                 2895             


Glu Leu  Gly Lys Arg Lys Arg  Pro Arg Val Cys Thr  Lys Glu Glu 
    2900                 2905                 2910             


Phe Ile  Asn Lys Val Arg Ser  Asn Ala Ala Leu Gly  Ala Ile Phe 
    2915                 2920                 2925             


Glu Glu  Glu Lys Glu Trp Lys  Thr Ala Val Glu Ala  Val Asn Asp 
    2930                 2935                 2940             


Pro Arg  Phe Trp Ala Leu Val  Asp Lys Glu Arg Glu  His His Leu 
    2945                 2950                 2955             


Arg Gly  Glu Cys His Ser Cys  Val Tyr Asn Met Met  Gly Lys Arg 
    2960                 2965                 2970             


Glu Lys  Lys Gln Gly Glu Phe  Gly Lys Ala Lys Gly  Ser Arg Ala 
    2975                 2980                 2985             


Ile Trp  Tyr Met Trp Leu Gly  Ala Arg Phe Leu Glu  Phe Glu Ala 
    2990                 2995                 3000             


Leu Gly  Phe Leu Asn Glu Asp  His Trp Met Gly Arg  Glu Asn Ser 
    3005                 3010                 3015             


Gly Gly  Gly Val Glu Gly Leu  Gly Leu Gln Arg Leu  Gly Tyr Val 
    3020                 3025                 3030             


Leu Glu  Glu Met Ser Arg Ala  Pro Gly Gly Lys Met  Tyr Ala Asp 
    3035                 3040                 3045             


Asp Thr  Ala Gly Trp Asp Thr  Arg Ile Ser Lys Phe  Asp Leu Glu 
    3050                 3055                 3060             


Asn Glu  Ala Leu Ile Thr Asn  Gln Met Asp Glu Gly  His Arg Thr 
    3065                 3070                 3075             


Leu Ala  Leu Ala Val Ile Lys  Tyr Thr Tyr Gln Asn  Lys Val Val 
    3080                 3085                 3090             


Lys Val  Leu Arg Pro Ala Glu  Gly Gly Lys Thr Val  Met Asp Ile 
    3095                 3100                 3105             


Ile Ser  Arg Gln Asp Gln Arg  Gly Ser Gly Gln Val  Val Thr Tyr 
    3110                 3115                 3120             


Ala Leu  Asn Thr Phe Thr Asn  Leu Val Val Gln Leu  Ile Arg Asn 
    3125                 3130                 3135             


Met Glu  Ala Glu Glu Val Leu  Glu Met Gln Asp Leu  Trp Leu Leu 
    3140                 3145                 3150             


Arg Lys  Pro Glu Lys Val Thr  Arg Trp Leu Gln Ser  Ser Gly Trp 
    3155                 3160                 3165             


Asp Arg  Leu Lys Arg Met Ala  Val Ser Gly Asp Asp  Cys Val Val 
    3170                 3175                 3180             


Lys Pro  Ile Asp Asp Arg Phe  Ala His Ala Leu Arg  Phe Leu Asn 
    3185                 3190                 3195             


Asp Met  Gly Lys Val Arg Lys  Asp Thr Gln Glu Trp  Lys Pro Ser 
    3200                 3205                 3210             


Thr Gly  Trp Ser Asn Trp Glu  Glu Val Pro Phe Cys  Ser His His 
    3215                 3220                 3225             


Phe Asn  Lys Leu His Leu Lys  Asp Gly Arg Ser Ile  Val Val Pro 
    3230                 3235                 3240             


Cys Arg  His Gln Asp Glu Leu  Ile Gly Arg Ala Arg  Val Ser Pro 
    3245                 3250                 3255             


Gly Ala  Gly Trp Ser Ile Arg  Glu Thr Ala Cys Leu  Ala Lys Ser 
    3260                 3265                 3270             


Tyr Ala  Gln Met Trp Gln Leu  Leu Tyr Phe His Arg  Arg Asp Leu 
    3275                 3280                 3285             


Arg Leu  Met Ala Asn Ala Ile  Cys Ser Ala Val Pro  Val Asp Trp 
    3290                 3295                 3300             


Val Pro  Thr Gly Arg Thr Thr  Trp Ser Ile His Gly  Lys Gly Glu 
    3305                 3310                 3315             


Trp Met  Thr Thr Glu Asp Met  Leu Met Val Trp Asn  Arg Val Trp 
    3320                 3325                 3330             


Ile Glu  Glu Asn Asp His Met  Glu Asp Lys Thr Pro  Val Thr Lys 
    3335                 3340                 3345             


Trp Thr  Asp Ile Pro Tyr Leu  Gly Lys Arg Glu Asp  Leu Trp Cys 
    3350                 3355                 3360             


Gly Ser  Leu Ile Gly His Arg  Pro Arg Thr Thr Trp  Ala Glu Asn 
    3365                 3370                 3375             


Ile Lys  Asp Thr Val Ser Met  Val Arg Arg Ile Ile  Gly Asp Glu 
    3380                 3385                 3390             


Glu Lys  Tyr Met Asp Tyr Leu  Ser Thr Gln Val Arg  Tyr Leu Gly 
    3395                 3400                 3405             


Glu Glu  Gly Ser Thr Pro Gly  Val Leu 
    3410                 3415         


<210>  106
<211>  3423
<212>  PRT
<213>  Zika virus isolate Brazil-ZKV2015

<400>  106

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Thr Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Phe Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Val Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  107
<211>  3429
<212>  PRT
<213>  Spondweni virus strain SM-6 V-1 polyprotein

<400>  107

Met Lys Asn Pro Lys Arg Ala Gly Ser Ser Arg Leu Val Asn Met Leu 
1               5                   10                  15      


Arg Arg Gly Ala Ala Arg Val Ile Pro Pro Gly Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Val Gly Leu Leu Leu Gly Arg Gly Pro Ile Lys Met Ile Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Thr Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Lys Val Gly Lys Lys Glu Ala Ile Lys Ile 
65                  70                  75                  80  


Leu Thr Lys Phe Lys Ala Asp Val Gly Thr Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Asn Arg Lys Thr Lys Lys Arg Gly Val Glu Thr Gly Ile Val Phe Leu 
            100                 105                 110         


Ala Leu Leu Val Ser Ile Val Ala Val Glu Val Thr Lys Lys Gly Asp 
        115                 120                 125             


Thr Tyr Tyr Met Phe Ala Asp Lys Lys Asp Ala Gly Lys Val Val Thr 
    130                 135                 140                 


Phe Glu Thr Glu Ser Gly Pro Asn Arg Cys Ser Ile Gln Ala Met Asp 
145                 150                 155                 160 


Ile Gly His Met Cys Pro Ala Thr Met Ser Tyr Glu Cys Pro Val Leu 
                165                 170                 175     


Glu Pro Gln Tyr Glu Pro Glu Asp Val Asp Cys Trp Cys Asn Ser Thr 
            180                 185                 190         


Ala Ala Trp Ile Val Tyr Gly Thr Cys Thr His Lys Thr Thr Gly Glu 
        195                 200                 205             


Thr Arg Arg Ser Arg Arg Ser Ile Thr Leu Pro Ser His Ala Ser Gln 
    210                 215                 220                 


Lys Leu Glu Thr Arg Ser Ser Thr Trp Leu Glu Ser Arg Glu Tyr Ser 
225                 230                 235                 240 


Lys Tyr Leu Ile Lys Val Glu Asn Trp Ile Leu Arg Asn Pro Gly Tyr 
                245                 250                 255     


Ala Leu Val Ala Ala Val Ile Gly Trp Thr Leu Gly Ser Ser Arg Ser 
            260                 265                 270         


Gln Lys Ile Ile Phe Val Thr Leu Leu Met Leu Val Ala Pro Ala Tyr 
        275                 280                 285             


Ser Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met 
    290                 295                 300                 


Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val 
305                 310                 315                 320 


Thr Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr 
                325                 330                 335     


Thr Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala 
            340                 345                 350         


Asn Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu 
        355                 360                 365             


Ala Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly 
    370                 375                 380                 


Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
385                 390                 395                 400 


Ser Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly 
                405                 410                 415     


Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val 
            420                 425                 430         


His Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln 
        435                 440                 445             


His Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro 
    450                 455                 460                 


Arg Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys 
465                 470                 475                 480 


Glu Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser 
            500                 505                 510         


Leu Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr 
    530                 535                 540                 


Ala Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Met Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro 
        595                 600                 605             


Ser Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly 
    610                 615                 620                 


Glu Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn 
625                 630                 635                 640 


Ser Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr 
                645                 650                 655     


Glu Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ala Gly Ser Ser Ile Gly Arg Ala Phe Glu Ala Thr 
    690                 695                 700                 


Met Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Met Phe Asn Ser Val Gly Lys Phe Val His 
                725                 730                 735     


Gln Val Phe Gly Ser Ala Phe Lys Ala Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Thr Gln Leu Leu Ile Gly Phe Leu Leu Ile Trp Met Gly Leu Asn 
        755                 760                 765             


Ala Arg Gly Gly Thr Val Ala Met Ser Phe Met Gly Ile Gly Ala Met 
    770                 775                 780                 


Leu Ile Phe Leu Ala Thr Ser Val Ser Gly Asp Thr Gly Cys Ser Val 
785                 790                 795                 800 


Asp Ile Ser Arg Arg Glu Met Arg Cys Gly Ser Gly Ile Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Asp Ala Trp Arg Ser Arg Tyr Lys Tyr His Pro Glu Thr 
            820                 825                 830         


Pro Arg Ala Leu Ala Ala Ala Val Lys Thr Ala Trp Glu Glu Gly Thr 
        835                 840                 845             


Cys Gly Ile Thr Ser Val Ser Arg Met Glu Asn Leu Met Trp Ser Ser 
    850                 855                 860                 


Val Ala Gly Glu Leu Asn Ala Ile Leu Glu Asp Asn Ser Val Pro Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Glu Pro Lys Tyr Pro Leu Tyr Asn Ala Pro Lys 
                885                 890                 895     


Arg Leu Lys Pro Pro Ala Ser Glu Leu Pro Gln Gly Trp Lys Ser Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Ser Ala Ala Lys Asn Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Met Lys Glu Cys Pro Arg Gln Lys Arg Ala Trp 
    930                 935                 940                 


Asn Ser Leu Arg Ile Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Ile Trp Leu Lys Phe His Glu Asp Asn Ser Thr Glu Cys Asp Thr Ala 
                965                 970                 975     


Ile Ile Gly Thr Ala Val Arg Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Arg  Asn Asp Thr Trp Arg  Leu Ser Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Ala Lys  Thr Cys Glu Trp Pro  Arg Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Glu Leu  Ile Ile Pro 
    1025                 1030                 1035             


Arg Gly  Leu Ala Gly Pro Phe  Ser His His Asn Thr  Arg Ala Gly 
    1040                 1045                 1050             


Tyr Lys  Thr Gln Asn Lys Gly  Pro Trp His Leu Gly  Asp Val Glu 
    1055                 1060                 1065             


Ile Gln  Phe Ala Thr Cys Pro  Gly Thr Thr Val Val  Gln Asp Gln 
    1070                 1075                 1080             


Glu Cys  Arg Asp Arg Gly Ala  Ser Leu Arg Thr Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Asn Glu Trp  Cys Cys Arg Ser Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Lys Thr Lys  Asp Gly Cys Trp Tyr  Ala Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Val Lys Glu Gln  Glu Ser Asn Leu Val  Arg Ser His 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Leu Val  Val Val Met Leu Met  Val Gln Glu Gly Met  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Ser Lys Ala Ile Ile  Thr Ser Ala Ala Phe  Leu Leu Ala 
    1175                 1180                 1185             


Val Met  Ile Val Gly Gly Phe  Thr Tyr Gln Asp Phe  Gly Arg Leu 
    1190                 1195                 1200             


Val Val  Leu Val Gly Ala Ala  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Met  Leu Val Ser Phe Met  Phe Arg Ala Leu Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Leu Leu Leu Ala Leu  Ala Ala Cys Leu Leu  Gln Val Ser 
    1250                 1255                 1260             


Val Thr  Pro Leu Asp His Ser  Ile Met Ile Val Val  Asp Gly Ile 
    1265                 1270                 1275             


Ala Leu  Ser Trp Leu Cys Leu  Lys Ala Ile Leu Val  Pro Arg Thr 
    1280                 1285                 1290             


Pro Asn  Ile Ala Leu Pro Leu  Leu Ala Met Leu Ser  Pro Met Leu 
    1295                 1300                 1305             


Gln Gly  Thr Thr Ile Val Ala  Trp Arg Ala Met Met  Ala Ala Leu 
    1310                 1315                 1320             


Ala Val  Ile Thr Leu Ala Ser  Met Lys His Gly Arg  Gly Val Lys 
    1325                 1330                 1335             


Lys Thr  Phe Pro Tyr Thr Ile  Gly Cys Ile Leu Gly  Ser Met Gly 
    1340                 1345                 1350             


Leu Val  Glu Asn Leu Gly Leu  Val Gly Leu Leu Leu  Leu Thr Ala 
    1355                 1360                 1365             


Ser Lys  Lys Arg Ser Trp Pro  Pro Ser Glu Val Met  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Ile Val  Gly Gly Leu Thr Lys  Thr Asp Ile 
    1385                 1390                 1395             


Asp Met  Ala Gly Pro Met Ala  Ala Ile Gly Leu Leu  Val Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Lys Val 
    1415                 1420                 1425             


Cys Asp  Ile Ser Trp Asp Lys  Asp Ala Glu Ile Thr  Gly Thr Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Asp Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Ile Gln  Asp Asp Gly Pro Pro  Thr Arg Glu Ile Val  Leu Lys Val 
    1460                 1465                 1470             


Phe Leu  Met Cys Val Cys Gly  Val Ser Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Ala Ala Trp Phe Val  Tyr Ile Lys Ser Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Met Trp Asp Ile Pro  Ser Pro Arg Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Ala Gly Val Tyr  Arg Ile Met Thr Arg  Lys Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Ala  Gly Val Met His Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asn Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Ile Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Gly Lys  Trp Asp Gly 
    1580                 1585                 1590             


Val Ser  Glu Val Gln Leu Ile  Ala Val Ala Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Val Gln Thr Lys Pro  Gly Val Phe Lys Thr  Thr Asp Gly 
    1610                 1615                 1620             


Glu Ile  Gly Ala Leu Ala Leu  Asp Phe Pro Gly Gly  Ser Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Ile Asp Lys Asn  Gly His Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Val Lys Ser  Gly Ser Tyr Val Ser  Ala Ile Met 
    1655                 1660                 1665             


Gln Thr  Glu Lys Met Glu Glu  Pro Ala Val Asp Cys  Phe Glu Glu 
    1670                 1675                 1680             


Asp Met  Leu Arg Lys Lys Lys  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Gln Ile  Val Lys Ala 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Ala  Glu Ala Leu Lys Asp  Leu Pro Ile 
    1730                 1735                 1740             


Arg Tyr  Met Thr Pro Ala Val  Ser Ala Thr His Asp  Gly Asn Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Met 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ala Thr  Arg Val Asp Met Gly  Asp Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Ser Thr  Glu Ala Phe Pro Asp  Ser Asn Ala 
    1820                 1825                 1830             


Pro Ile  Thr Asp Val Glu Thr  Glu Val Pro Asp Lys  Ala Trp Asn 
    1835                 1840                 1845             


Ser Gly  Phe Glu Trp Ile Thr  Asp Tyr Pro Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Met  Gly Asn Glu Ile Ser  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Ser Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Tyr Gln Lys Thr  Lys Asn Gly Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Lys  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Asp Met  Glu Glu Arg Val Val  Leu Ala Gly Pro Met  Ala Val Thr 
    1940                 1945                 1950             


Pro Ser  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro 
    1955                 1960                 1965             


Asn Lys  Thr Gly Asp Glu Phe  Tyr Tyr Gly Gly Gly  Cys Ala Ala 
    1970                 1975                 1980             


Thr Asp  Asp Asp His Ala His  Trp Val Glu Ala Arg  Met Leu Leu 
    1985                 1990                 1995             


Asp Asn  Ile Tyr Leu Gln Asp  Asn Leu Val Ala Ser  Leu Tyr Lys 
    2000                 2005                 2010             


Pro Glu  Gln Gly Lys Val Ser  Ala Ile Glu Gly Glu  Phe Lys Leu 
    2015                 2020                 2025             


Arg Gly  Glu Gln Arg Lys Thr  Phe Val Glu Leu Met  Lys Arg Gly 
    2030                 2035                 2040             


Asp Leu  Pro Val Trp Leu Ser  Tyr Gln Val Ala Ala  Ser Gly Leu 
    2045                 2050                 2055             


Ser Tyr  Thr Asp Arg Arg Trp  Cys Phe Asp Gly Lys  Asn Asn Asn 
    2060                 2065                 2070             


Thr Ile  Leu Glu Asp Cys Val  Pro Val Glu Val Trp  Thr Lys Phe 
    2075                 2080                 2085             


Gly Glu  Lys Lys Ile Leu Lys  Pro Arg Trp Met Asp  Ala Arg Ile 
    2090                 2095                 2100             


Cys Ser  Asp His Ala Ser Leu  Lys Ser Phe Lys Glu  Phe Ala Ala 
    2105                 2110                 2115             


Gly Lys  Arg Thr Ile Ala Thr  Gly Leu Ile Glu Ala  Phe Gly Met 
    2120                 2125                 2130             


Leu Pro  Gly His Met Thr Glu  Arg Phe Gln Glu Ala  Val Asp Asn 
    2135                 2140                 2145             


Leu Ala  Val Leu Met Arg Ala  Glu Ala Gly Ser Arg  Ala His Arg 
    2150                 2155                 2160             


Met Ala  Ala Ala Gln Leu Pro  Glu Thr Met Glu Thr  Ile Leu Leu 
    2165                 2170                 2175             


Leu Ser  Leu Leu Ala Phe Val  Ser Leu Gly Val Phe  Phe Val Leu 
    2180                 2185                 2190             


Met Arg  Ala Lys Gly Leu Gly  Lys Met Gly Ser Gly  Met Ile Val 
    2195                 2200                 2205             


Leu Ala  Gly Ser Gly Trp Leu  Met Trp Met Ser Glu  Val Glu Pro 
    2210                 2215                 2220             


Ala Arg  Ile Ala Cys Val Val  Ile Ile Val Phe Leu  Leu Met Val 
    2225                 2230                 2235             


Val Leu  Ile Pro Glu Pro Glu  Lys Gln Arg Ser Pro  Gln Asp Asn 
    2240                 2245                 2250             


Gln Leu  Ala Leu Ile Ile Leu  Ile Ala Thr Gly Leu  Ile Thr Leu 
    2255                 2260                 2265             


Ile Ala  Ala Asn Glu Leu Gly  Trp Leu Glu Arg Thr  Lys Ser Asp 
    2270                 2275                 2280             


Leu Thr  Arg Leu Phe Trp Arg  Glu His Ala Glu Pro  Thr Gly Gly 
    2285                 2290                 2295             


Arg Gly  Phe Ser Phe Ser Leu  Asp Ile Asp Leu Arg  Pro Ala Ser 
    2300                 2305                 2310             


Ala Trp  Ala Ile Tyr Ala Ala  Met Thr Thr Leu Ile  Thr Pro Thr 
    2315                 2320                 2325             


Val Gln  His Ala Val Thr Thr  Ser Tyr Asn Asn Tyr  Ser Leu Met 
    2330                 2335                 2340             


Ala Met  Ala Thr Gln Ala Gly  Val Leu Phe Gly Met  Gly Arg Gly 
    2345                 2350                 2355             


Val Pro  Phe Tyr Lys Trp Asp  Phe Gly Val Pro Leu  Leu Met Leu 
    2360                 2365                 2370             


Gly Cys  Tyr Ser Gln Leu Thr  Pro Leu Thr Leu Ile  Val Ala Leu 
    2375                 2380                 2385             


Val Met  Leu Ala Ala His Tyr  Leu Tyr Leu Ile Pro  Gly Leu Gln 
    2390                 2395                 2400             


Ala Thr  Ala Ala Arg Ala Ala  Gln Arg Arg Thr Ala  Ala Gly Ile 
    2405                 2410                 2415             


Met Lys  Asn Pro Val Val Asp  Gly Ile Val Val Thr  Asp Ile Asp 
    2420                 2425                 2430             


Pro Ile  Gln Ile Asp Pro Asn  Val Glu Lys Lys Met  Gly Gln Val 
    2435                 2440                 2445             


Met Leu  Ile Phe Val Ala Leu  Ala Ser Ala Val Leu  Met Arg Thr 
    2450                 2455                 2460             


Ala Trp  Gly Trp Gly Glu Ala  Gly Ala Leu Ala Ser  Ala Ala Ala 
    2465                 2470                 2475             


Ala Thr  Leu Trp Glu Gly Ala  Pro Asn Lys Tyr Trp  Asn Ser Ser 
    2480                 2485                 2490             


Thr Ala  Thr Ser Leu Cys Asn  Ile Phe Arg Gly Ser  Tyr Leu Ala 
    2495                 2500                 2505             


Gly Pro  Ser Leu Ile Tyr Thr  Val Thr Arg Asn Ala  Gly Ile Met 
    2510                 2515                 2520             


Lys Lys  Arg Gly Gly Gly Asn  Gly Glu Thr Val Gly  Glu Lys Trp 
    2525                 2530                 2535             


Lys Glu  Arg Leu Asn Arg Met  Thr Ala Leu Glu Phe  Tyr Ala Tyr 
    2540                 2545                 2550             


Lys Arg  Ser Gly Ile Thr Glu  Val Cys Arg Glu Pro  Ala Arg Arg 
    2555                 2560                 2565             


Ala Leu  Lys Asp Gly Val Val  Thr Gly Gly His Ala  Val Ser Arg 
    2570                 2575                 2580             


Gly Ser  Ala Lys Leu Arg Trp  Met Val Glu Arg Gly  His Val Asn 
    2585                 2590                 2595             


Leu Val  Gly Arg Val Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp 
    2600                 2605                 2610             


Ser Tyr  Tyr Ala Ala Ser Gln  Lys Gln Val Leu Glu  Val Arg Gly 
    2615                 2620                 2625             


Tyr Thr  Lys Gly Gly Ala Gly  His Glu Glu Pro Met  Asn Val Gln 
    2630                 2635                 2640             


Ser Tyr  Gly Trp Asn Ile Val  Arg Leu Lys Ser Gly  Val Asp Val 
    2645                 2650                 2655             


Phe Tyr  Leu Pro Ser Glu Pro  Cys Asp Thr Leu Leu  Cys Asp Ile 
    2660                 2665                 2670             


Gly Glu  Ser Ser Ser Ser Pro  Ala Val Glu Glu Ala  Arg Thr Leu 
    2675                 2680                 2685             


Arg Val  Leu Gly Met Val Glu  Thr Trp Leu Glu Arg  Gly Val Lys 
    2690                 2695                 2700             


Asn Phe  Cys Ile Lys Val Leu  Cys Pro Tyr Thr Ser  Ala Met Ile 
    2705                 2710                 2715             


Glu Arg  Leu Glu Ala Leu Gln  Arg Arg Tyr Gly Gly  Gly Leu Val 
    2720                 2725                 2730             


Arg Val  Pro Leu Ser Arg Asn  Ser Thr His Glu Met  Tyr Trp Val 
    2735                 2740                 2745             


Ser Gly  Ala Lys Ser Asn Ile  Ile Arg Ser Val Asn  Ala Thr Ser 
    2750                 2755                 2760             


Gln Leu  Leu Met His Arg Met  Asp Ile Pro Thr Arg  Lys Thr Lys 
    2765                 2770                 2775             


Phe Glu  Glu Asp Val Asn Leu  Gly Thr Gly Thr Arg  Ala Val Glu 
    2780                 2785                 2790             


Ser Arg  Ala Asp Pro Pro Asp  Met Lys Lys Leu Gly  Ser Arg Ile 
    2795                 2800                 2805             


Glu Arg  Leu Arg Lys Glu Tyr  Gly Ser Thr Trp His  Tyr Asp Glu 
    2810                 2815                 2820             


Asn His  Pro Tyr Arg Thr Trp  His Tyr His Gly Ser  Tyr Glu Ala 
    2825                 2830                 2835             


Asp Thr  Gln Gly Ser Ala Ser  Ser Met Val Asn Gly  Val Val Arg 
    2840                 2845                 2850             


Leu Leu  Ser Lys Pro Trp Asp  Ala Leu Ser Ser Val  Thr Asn Ile 
    2855                 2860                 2865             


Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys 
    2870                 2875                 2880             


Glu Lys  Val Asp Thr Arg Thr  Pro Asp Pro Lys Gln  Gly Thr Gln 
    2885                 2890                 2895             


Arg Val  Met Ala Ile Thr Ser  Gln Trp Leu Trp Asp  Arg Leu Ala 
    2900                 2905                 2910             


Arg Asn  Lys Thr Pro Arg Met  Cys Thr Arg Gln Glu  Phe Ile Asn 
    2915                 2920                 2925             


Lys Val  Asn Ser His Ala Ala  Leu Gly Pro Val Phe  Arg Glu Gln 
    2930                 2935                 2940             


Gln Gly  Trp Gly Ser Ala Ala  Glu Ala Val Val Asp  Pro Arg Phe 
    2945                 2950                 2955             


Trp Glu  Leu Val Asp Asn Glu  Arg Glu Ala His Leu  Arg Gly Glu 
    2960                 2965                 2970             


Cys Leu  Thr Cys Val Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys 
    2975                 2980                 2985             


Leu Gly  Glu Phe Gly Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr 
    2990                 2995                 3000             


Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe 
    3005                 3010                 3015             


Leu Asn  Glu Asp His Trp Leu  Ser Arg Glu Asn Ser  Gly Gly Gly 
    3020                 3025                 3030             


Val Glu  Gly Leu Gly Leu Gln  Lys Leu Gly Tyr Ile  Leu Glu Glu 
    3035                 3040                 3045             


Ile Ser  Arg Arg Pro Gly Gly  Lys Met Tyr Ala Asp  Asp Thr Ala 
    3050                 3055                 3060             


Gly Trp  Asp Thr Arg Ile Thr  Lys Cys Asp Leu Glu  Asn Glu Ala 
    3065                 3070                 3075             


Arg Ile  Leu Glu Lys Met Asp  Gly Ile His Lys Lys  Leu Ala Arg 
    3080                 3085                 3090             


Ala Val  Ile Glu Leu Thr Tyr  Lys His Lys Val Val  Arg Val Leu 
    3095                 3100                 3105             


Arg Pro  Ala Pro Gln Gly Lys  Val Val Met Asp Ile  Ile Ser Arg 
    3110                 3115                 3120             


Pro Asp  Gln Arg Gly Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn 
    3125                 3130                 3135             


Thr Tyr  Thr Asn Leu Val Val  Gln Leu Ile Arg Asn  Met Glu Ala 
    3140                 3145                 3150             


Glu Ala  Val Ile Asn Glu Arg  Asp Met Glu Glu Leu  Gln Asn Pro 
    3155                 3160                 3165             


Trp Lys  Val Ile Asn Trp Leu  Glu Gly Asn Gly Trp  Asp Arg Leu 
    3170                 3175                 3180             


Arg Ser  Met Ala Val Ser Gly  Asp Asp Cys Val Val  Lys Pro Met 
    3185                 3190                 3195             


Asp Asp  Arg Phe Ala Tyr Ala  Leu Asn Phe Leu Asn  Asp Met Gly 
    3200                 3205                 3210             


Lys Val  Arg Lys Asp Val Gln  Glu Trp Lys Pro Ser  Pro Gly Trp 
    3215                 3220                 3225             


Thr Asn  Trp Glu Glu Val Pro  Phe Cys Ser His His  Phe Asn Lys 
    3230                 3235                 3240             


Leu Pro  Met Lys Asp Gly Arg  Thr Ile Ile Val Pro  Cys Arg His 
    3245                 3250                 3255             


Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Val Ser Pro  Gly Lys Gly 
    3260                 3265                 3270             


Trp Ser  Leu Ser Glu Thr Ala  Cys Leu Gly Lys Ser  Tyr Ala Gln 
    3275                 3280                 3285             


Met Trp  Leu Leu Leu Tyr Phe  His Arg Arg Asp Leu  Arg Leu Met 
    3290                 3295                 3300             


Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val Ser Trp  Val Pro Thr 
    3305                 3310                 3315             


Gly Arg  Thr Thr Trp Ser Ile  His Gly Arg Gly Glu  Trp Met Thr 
    3320                 3325                 3330             


Thr Glu  Asp Met Leu Glu Val  Trp Asn Arg Val Trp  Ile Ile Glu 
    3335                 3340                 3345             


Asn Glu  Tyr Met Glu Asp Lys  Thr Pro Val Thr Glu  Trp Thr Asp 
    3350                 3355                 3360             


Val Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu Trp Cys  Gly Ser Leu 
    3365                 3370                 3375             


Ile Gly  His Arg Pro Arg Ser  Thr Trp Ala Glu Asn  Ile Trp Ala 
    3380                 3385                 3390             


Ala Ile  Tyr Gln Val Arg Arg  Ala Ile Gly Glu Thr  Glu Glu Tyr 
    3395                 3400                 3405             


Arg Asp  Tyr Met Ser Thr Gln  Val Arg Tyr Gly Ser  Glu Glu Gly 
    3410                 3415                 3420             


Pro Ser  Ala Gly Val Leu 
    3425                 


<210>  108
<211>  3429
<212>  PRT
<213>  Spondweni virus, NCBI Reference Sequence: NC_029055.1

<400>  108

Met Lys Asn Pro Lys Arg Ala Gly Ser Ser Arg Leu Val Asn Met Leu 
1               5                   10                  15      


Arg Arg Gly Ala Ala Arg Val Ile Pro Pro Gly Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Val Gly Leu Leu Leu Gly Arg Gly Pro Ile Lys Met Ile Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Thr Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Lys Val Gly Lys Lys Glu Ala Ile Lys Ile 
65                  70                  75                  80  


Leu Thr Lys Phe Lys Ala Asp Val Gly Thr Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Asn Arg Lys Thr Lys Lys Arg Gly Val Glu Thr Gly Ile Val Phe Leu 
            100                 105                 110         


Ala Leu Leu Val Ser Ile Val Ala Val Glu Val Thr Lys Lys Gly Asp 
        115                 120                 125             


Thr Tyr Tyr Met Phe Ala Asp Lys Lys Asp Ala Gly Lys Val Val Thr 
    130                 135                 140                 


Phe Glu Thr Glu Ser Gly Pro Asn Arg Cys Ser Ile Gln Ala Met Asp 
145                 150                 155                 160 


Ile Gly His Met Cys Pro Ala Thr Met Ser Tyr Glu Cys Pro Val Leu 
                165                 170                 175     


Glu Pro Gln Tyr Glu Pro Glu Asp Val Asp Cys Trp Cys Asn Ser Thr 
            180                 185                 190         


Ala Ala Trp Ile Val Tyr Gly Thr Cys Thr His Lys Thr Thr Gly Glu 
        195                 200                 205             


Thr Arg Arg Ser Arg Arg Ser Ile Thr Leu Pro Ser His Ala Ser Gln 
    210                 215                 220                 


Lys Leu Glu Thr Arg Ser Ser Thr Trp Leu Glu Ser Arg Glu Tyr Ser 
225                 230                 235                 240 


Lys Tyr Leu Ile Lys Val Glu Asn Trp Ile Leu Arg Asn Pro Gly Tyr 
                245                 250                 255     


Ala Leu Val Ala Ala Val Ile Gly Trp Thr Leu Gly Ser Ser Arg Ser 
            260                 265                 270         


Gln Lys Ile Ile Phe Val Thr Leu Leu Met Leu Val Ala Pro Ala Tyr 
        275                 280                 285             


Ser Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met 
    290                 295                 300                 


Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val 
305                 310                 315                 320 


Thr Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr 
                325                 330                 335     


Thr Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala 
            340                 345                 350         


Asn Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu 
        355                 360                 365             


Ala Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly 
    370                 375                 380                 


Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
385                 390                 395                 400 


Ser Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly 
                405                 410                 415     


Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val 
            420                 425                 430         


His Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln 
        435                 440                 445             


His Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro 
    450                 455                 460                 


Arg Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys 
465                 470                 475                 480 


Glu Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser 
            500                 505                 510         


Leu Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr 
    530                 535                 540                 


Ala Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Met Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro 
        595                 600                 605             


Ser Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly 
    610                 615                 620                 


Glu Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn 
625                 630                 635                 640 


Ser Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr 
                645                 650                 655     


Glu Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ala Gly Ser Ser Ile Gly Arg Ala Phe Glu Ala Thr 
    690                 695                 700                 


Met Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Met Phe Asn Ser Val Gly Lys Phe Val His 
                725                 730                 735     


Gln Val Phe Gly Ser Ala Phe Lys Ala Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Thr Gln Leu Leu Ile Gly Phe Leu Leu Ile Trp Met Gly Leu Asn 
        755                 760                 765             


Ala Arg Gly Gly Thr Val Ala Met Ser Phe Met Gly Ile Gly Ala Met 
    770                 775                 780                 


Leu Ile Phe Leu Ala Thr Ser Val Ser Gly Asp Thr Gly Cys Ser Val 
785                 790                 795                 800 


Asp Ile Ser Arg Arg Glu Met Arg Cys Gly Ser Gly Ile Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Asp Ala Trp Arg Ser Arg Tyr Lys Tyr His Pro Glu Thr 
            820                 825                 830         


Pro Arg Ala Leu Ala Ala Ala Val Lys Thr Ala Trp Glu Glu Gly Thr 
        835                 840                 845             


Cys Gly Ile Thr Ser Val Ser Arg Met Glu Asn Leu Met Trp Ser Ser 
    850                 855                 860                 


Val Ala Gly Glu Leu Asn Ala Ile Leu Glu Asp Asn Ser Val Pro Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Glu Pro Lys Tyr Pro Leu Tyr Asn Ala Pro Lys 
                885                 890                 895     


Arg Leu Lys Pro Pro Ala Ser Glu Leu Pro Gln Gly Trp Lys Ser Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Ser Ala Ala Lys Asn Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Met Lys Glu Cys Pro Arg Gln Lys Arg Ala Trp 
    930                 935                 940                 


Asn Ser Leu Arg Ile Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Ile Trp Leu Lys Phe His Glu Asp Asn Ser Thr Glu Cys Asp Thr Ala 
                965                 970                 975     


Ile Ile Gly Thr Ala Val Arg Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Arg  Asn Asp Thr Trp Arg  Leu Ser Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Ala Lys  Thr Cys Glu Trp Pro  Arg Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Val  Glu Glu Ser Glu Leu  Ile Ile Pro 
    1025                 1030                 1035             


Arg Gly  Leu Ala Gly Pro Phe  Ser His His Asn Thr  Arg Ala Gly 
    1040                 1045                 1050             


Tyr Lys  Thr Gln Asn Lys Gly  Pro Trp His Leu Gly  Asp Val Glu 
    1055                 1060                 1065             


Ile Gln  Phe Ala Thr Cys Pro  Gly Thr Thr Val Val  Gln Asp Gln 
    1070                 1075                 1080             


Glu Cys  Arg Asp Arg Gly Ala  Ser Leu Arg Thr Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Asn Glu Trp  Cys Cys Arg Ser Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Lys Thr Lys  Asp Gly Cys Trp Tyr  Ala Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Val Lys Glu Gln  Glu Ser Asn Leu Val  Arg Ser His 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Leu Val  Val Val Met Leu Met  Val Gln Glu Gly Met  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Ser Lys Ala Ile Ile  Thr Ser Ala Ala Phe  Leu Leu Ala 
    1175                 1180                 1185             


Val Met  Ile Val Gly Gly Phe  Thr Tyr Gln Asp Phe  Gly Arg Leu 
    1190                 1195                 1200             


Val Val  Leu Val Gly Ala Ala  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Val Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Met  Leu Val Ser Phe Met  Phe Arg Ala Leu Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Leu Leu Leu Ala Leu  Ala Ala Cys Leu Leu  Gln Val Ser 
    1250                 1255                 1260             


Val Thr  Pro Leu Asp His Ser  Ile Met Ile Val Val  Asp Gly Ile 
    1265                 1270                 1275             


Ala Leu  Ser Trp Leu Cys Leu  Lys Ala Ile Leu Val  Pro Arg Thr 
    1280                 1285                 1290             


Pro Asn  Ile Ala Leu Pro Leu  Leu Ala Met Leu Ser  Pro Met Leu 
    1295                 1300                 1305             


Gln Gly  Thr Thr Ile Val Ala  Trp Arg Ala Met Met  Ala Ala Leu 
    1310                 1315                 1320             


Ala Val  Ile Thr Leu Ala Ser  Met Lys His Gly Arg  Gly Val Lys 
    1325                 1330                 1335             


Lys Thr  Phe Pro Tyr Thr Ile  Gly Cys Ile Leu Gly  Ser Met Gly 
    1340                 1345                 1350             


Leu Val  Glu Asn Leu Gly Leu  Val Gly Leu Leu Leu  Leu Thr Ala 
    1355                 1360                 1365             


Ser Lys  Lys Arg Ser Trp Pro  Pro Ser Glu Val Met  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Ile Val  Gly Gly Leu Thr Lys  Thr Asp Ile 
    1385                 1390                 1395             


Asp Met  Ala Gly Pro Met Ala  Ala Ile Gly Leu Leu  Val Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Lys Val 
    1415                 1420                 1425             


Cys Asp  Ile Ser Trp Asp Lys  Asp Ala Glu Ile Thr  Gly Thr Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Asp Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Ile Gln  Asp Asp Gly Pro Pro  Thr Arg Glu Ile Val  Leu Lys Val 
    1460                 1465                 1470             


Phe Leu  Met Cys Val Cys Gly  Val Ser Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Ala Ala Trp Phe Val  Tyr Ile Lys Ser Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Met Trp Asp Ile Pro  Ser Pro Arg Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Ala Gly Val Tyr  Arg Ile Met Thr Arg  Lys Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Ala  Gly Val Met His Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asn Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Ile Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Gly Lys  Trp Asp Gly 
    1580                 1585                 1590             


Val Ser  Glu Val Gln Leu Ile  Ala Val Ala Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Val Gln Thr Lys Pro  Gly Val Phe Lys Thr  Thr Asp Gly 
    1610                 1615                 1620             


Glu Ile  Gly Ala Leu Ala Leu  Asp Phe Pro Gly Gly  Ser Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Ile Asp Lys Asn  Gly His Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Val Lys Ser  Gly Ser Tyr Val Ser  Ala Ile Met 
    1655                 1660                 1665             


Gln Thr  Glu Lys Met Glu Glu  Pro Ala Val Asp Cys  Phe Glu Glu 
    1670                 1675                 1680             


Asp Met  Leu Arg Lys Lys Lys  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Gln Ile  Val Lys Ala 
    1700                 1705                 1710             


Ala Ile  Lys Lys Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Ala  Glu Ala Leu Lys Asp  Leu Pro Ile 
    1730                 1735                 1740             


Arg Tyr  Met Thr Pro Ala Val  Ser Ala Thr His Asp  Gly Asn Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Met 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ala Thr  Arg Val Asp Met Gly  Asp Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Ser Thr  Glu Ala Phe Pro Asp  Ser Asn Ala 
    1820                 1825                 1830             


Pro Ile  Thr Asp Val Glu Thr  Glu Val Pro Asp Lys  Ala Trp Asn 
    1835                 1840                 1845             


Ser Gly  Phe Glu Trp Ile Thr  Asp Tyr Pro Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Met  Gly Asn Glu Ile Ser  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Ser Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Tyr Gln Lys Thr  Lys Asn Gly Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Lys  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Asp Met  Glu Glu Arg Val Val  Leu Ala Gly Pro Met  Ala Val Thr 
    1940                 1945                 1950             


Pro Ser  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro 
    1955                 1960                 1965             


Asn Lys  Thr Gly Asp Glu Phe  Tyr Tyr Gly Gly Gly  Cys Ala Ala 
    1970                 1975                 1980             


Thr Asp  Asp Asp His Ala His  Trp Val Glu Ala Arg  Met Leu Leu 
    1985                 1990                 1995             


Asp Asn  Ile Tyr Leu Gln Asp  Asn Leu Val Ala Ser  Leu Tyr Lys 
    2000                 2005                 2010             


Pro Glu  Gln Gly Lys Val Ser  Ala Ile Glu Gly Glu  Phe Lys Leu 
    2015                 2020                 2025             


Arg Gly  Glu Gln Arg Lys Thr  Phe Val Glu Leu Met  Lys Arg Gly 
    2030                 2035                 2040             


Asp Leu  Pro Val Trp Leu Ser  Tyr Gln Val Ala Ala  Ser Gly Leu 
    2045                 2050                 2055             


Ser Tyr  Thr Asp Arg Arg Trp  Cys Phe Asp Gly Lys  Asn Asn Asn 
    2060                 2065                 2070             


Thr Ile  Leu Glu Asp Cys Val  Pro Val Glu Val Trp  Thr Lys Phe 
    2075                 2080                 2085             


Gly Glu  Lys Lys Ile Leu Lys  Pro Arg Trp Met Asp  Ala Arg Ile 
    2090                 2095                 2100             


Cys Ser  Asp His Ala Ser Leu  Lys Ser Phe Lys Glu  Phe Ala Ala 
    2105                 2110                 2115             


Gly Lys  Arg Thr Ile Ala Thr  Gly Leu Ile Glu Ala  Phe Gly Met 
    2120                 2125                 2130             


Leu Pro  Gly His Met Thr Glu  Arg Phe Gln Glu Ala  Val Asp Asn 
    2135                 2140                 2145             


Leu Ala  Val Leu Met Arg Ala  Glu Ala Gly Ser Arg  Ala His Arg 
    2150                 2155                 2160             


Met Ala  Ala Ala Gln Leu Pro  Glu Thr Met Glu Thr  Ile Leu Leu 
    2165                 2170                 2175             


Leu Ser  Leu Leu Ala Phe Val  Ser Leu Gly Val Phe  Phe Val Leu 
    2180                 2185                 2190             


Met Arg  Ala Lys Gly Leu Gly  Lys Met Gly Ser Gly  Met Ile Val 
    2195                 2200                 2205             


Leu Ala  Gly Ser Gly Trp Leu  Met Trp Met Ser Glu  Val Glu Pro 
    2210                 2215                 2220             


Ala Arg  Ile Ala Cys Val Val  Ile Ile Val Phe Leu  Leu Met Val 
    2225                 2230                 2235             


Val Leu  Ile Pro Glu Pro Glu  Lys Gln Arg Ser Pro  Gln Asp Asn 
    2240                 2245                 2250             


Gln Leu  Ala Leu Ile Ile Leu  Ile Ala Thr Gly Leu  Ile Thr Leu 
    2255                 2260                 2265             


Ile Ala  Ala Asn Glu Leu Gly  Trp Leu Glu Arg Thr  Lys Ser Asp 
    2270                 2275                 2280             


Leu Thr  Arg Leu Phe Trp Arg  Glu His Ala Glu Pro  Thr Gly Gly 
    2285                 2290                 2295             


Arg Gly  Phe Ser Phe Ser Leu  Asp Ile Asp Leu Arg  Pro Ala Ser 
    2300                 2305                 2310             


Ala Trp  Ala Ile Tyr Ala Ala  Met Thr Thr Leu Ile  Thr Pro Thr 
    2315                 2320                 2325             


Val Gln  His Ala Val Thr Thr  Ser Tyr Asn Asn Tyr  Ser Leu Met 
    2330                 2335                 2340             


Ala Met  Ala Thr Gln Ala Gly  Val Leu Phe Gly Met  Gly Arg Gly 
    2345                 2350                 2355             


Val Pro  Phe Tyr Lys Trp Asp  Phe Gly Val Pro Leu  Leu Met Leu 
    2360                 2365                 2370             


Gly Cys  Tyr Ser Gln Leu Thr  Pro Leu Thr Leu Ile  Val Ala Leu 
    2375                 2380                 2385             


Val Met  Leu Ala Ala His Tyr  Leu Tyr Leu Ile Pro  Gly Leu Gln 
    2390                 2395                 2400             


Ala Thr  Ala Ala Arg Ala Ala  Gln Arg Arg Thr Ala  Ala Gly Ile 
    2405                 2410                 2415             


Met Lys  Asn Pro Val Val Asp  Gly Ile Val Val Thr  Asp Ile Asp 
    2420                 2425                 2430             


Pro Ile  Gln Ile Asp Pro Asn  Val Glu Lys Lys Met  Gly Gln Val 
    2435                 2440                 2445             


Met Leu  Ile Phe Val Ala Leu  Ala Ser Ala Val Leu  Met Arg Thr 
    2450                 2455                 2460             


Ala Trp  Gly Trp Gly Glu Ala  Gly Ala Leu Ala Ser  Ala Ala Ala 
    2465                 2470                 2475             


Ala Thr  Leu Trp Glu Gly Ala  Pro Asn Lys Tyr Trp  Asn Ser Ser 
    2480                 2485                 2490             


Thr Ala  Thr Ser Leu Cys Asn  Ile Phe Arg Gly Ser  Tyr Leu Ala 
    2495                 2500                 2505             


Gly Pro  Ser Leu Ile Tyr Thr  Val Thr Arg Asn Ala  Gly Ile Met 
    2510                 2515                 2520             


Lys Lys  Arg Gly Gly Gly Asn  Gly Glu Thr Val Gly  Glu Lys Trp 
    2525                 2530                 2535             


Lys Glu  Arg Leu Asn Arg Met  Thr Ala Leu Glu Phe  Tyr Ala Tyr 
    2540                 2545                 2550             


Lys Arg  Ser Gly Ile Thr Glu  Val Cys Arg Glu Pro  Ala Arg Arg 
    2555                 2560                 2565             


Ala Leu  Lys Asp Gly Val Val  Thr Gly Gly His Ala  Val Ser Arg 
    2570                 2575                 2580             


Gly Ser  Ala Lys Leu Arg Trp  Met Val Glu Arg Gly  His Val Asn 
    2585                 2590                 2595             


Leu Val  Gly Arg Val Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp 
    2600                 2605                 2610             


Ser Tyr  Tyr Ala Ala Ser Gln  Lys Gln Val Leu Glu  Val Arg Gly 
    2615                 2620                 2625             


Tyr Thr  Lys Gly Gly Ala Gly  His Glu Glu Pro Met  Asn Val Gln 
    2630                 2635                 2640             


Ser Tyr  Gly Trp Asn Ile Val  Arg Leu Lys Ser Gly  Val Asp Val 
    2645                 2650                 2655             


Phe Tyr  Leu Pro Ser Glu Pro  Cys Asp Thr Leu Leu  Cys Asp Ile 
    2660                 2665                 2670             


Gly Glu  Ser Ser Ser Ser Pro  Ala Val Glu Glu Ala  Arg Thr Leu 
    2675                 2680                 2685             


Arg Val  Leu Gly Met Val Glu  Thr Trp Leu Glu Arg  Gly Val Lys 
    2690                 2695                 2700             


Asn Phe  Cys Ile Lys Val Leu  Cys Pro Tyr Thr Ser  Ala Met Ile 
    2705                 2710                 2715             


Glu Arg  Leu Glu Ala Leu Gln  Arg Arg Tyr Gly Gly  Gly Leu Val 
    2720                 2725                 2730             


Arg Val  Pro Leu Ser Arg Asn  Ser Thr His Glu Met  Tyr Trp Val 
    2735                 2740                 2745             


Ser Gly  Ala Lys Ser Asn Ile  Ile Arg Ser Val Asn  Ala Thr Ser 
    2750                 2755                 2760             


Gln Leu  Leu Met His Arg Met  Asp Ile Pro Thr Arg  Lys Thr Lys 
    2765                 2770                 2775             


Phe Glu  Glu Asp Val Asn Leu  Gly Thr Gly Thr Arg  Ala Val Glu 
    2780                 2785                 2790             


Ser Arg  Ala Asp Pro Pro Asp  Met Lys Lys Leu Gly  Ser Arg Ile 
    2795                 2800                 2805             


Glu Arg  Leu Arg Lys Glu Tyr  Gly Ser Thr Trp His  Tyr Asp Glu 
    2810                 2815                 2820             


Asn His  Pro Tyr Arg Thr Trp  His Tyr His Gly Ser  Tyr Glu Ala 
    2825                 2830                 2835             


Asp Thr  Gln Gly Ser Ala Ser  Ser Met Val Asn Gly  Val Val Arg 
    2840                 2845                 2850             


Leu Leu  Ser Lys Pro Trp Asp  Ala Leu Ser Ser Val  Thr Asn Ile 
    2855                 2860                 2865             


Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys 
    2870                 2875                 2880             


Glu Lys  Val Asp Thr Arg Thr  Pro Asp Pro Lys Gln  Gly Thr Gln 
    2885                 2890                 2895             


Arg Val  Met Ala Ile Thr Ser  Gln Trp Leu Trp Asp  Arg Leu Ala 
    2900                 2905                 2910             


Arg Asn  Lys Thr Pro Arg Met  Cys Thr Arg Gln Glu  Phe Ile Asn 
    2915                 2920                 2925             


Lys Val  Asn Ser His Ala Ala  Leu Gly Pro Val Phe  Arg Glu Gln 
    2930                 2935                 2940             


Gln Gly  Trp Gly Ser Ala Ala  Glu Ala Val Val Asp  Pro Arg Phe 
    2945                 2950                 2955             


Trp Glu  Leu Val Asp Asn Glu  Arg Glu Ala His Leu  Arg Gly Glu 
    2960                 2965                 2970             


Cys Leu  Thr Cys Val Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys 
    2975                 2980                 2985             


Leu Gly  Glu Phe Gly Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr 
    2990                 2995                 3000             


Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe 
    3005                 3010                 3015             


Leu Asn  Glu Asp His Trp Leu  Ser Arg Glu Asn Ser  Gly Gly Gly 
    3020                 3025                 3030             


Val Glu  Gly Leu Gly Leu Gln  Lys Leu Gly Tyr Ile  Leu Glu Glu 
    3035                 3040                 3045             


Ile Ser  Arg Arg Pro Gly Gly  Lys Met Tyr Ala Asp  Asp Thr Ala 
    3050                 3055                 3060             


Gly Trp  Asp Thr Arg Ile Thr  Lys Cys Asp Leu Glu  Asn Glu Ala 
    3065                 3070                 3075             


Arg Ile  Leu Glu Lys Met Asp  Gly Ile His Lys Lys  Leu Ala Arg 
    3080                 3085                 3090             


Ala Val  Ile Glu Leu Thr Tyr  Lys His Lys Val Val  Arg Val Leu 
    3095                 3100                 3105             


Arg Pro  Ala Pro Gln Gly Lys  Val Val Met Asp Ile  Ile Ser Arg 
    3110                 3115                 3120             


Pro Asp  Gln Arg Gly Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn 
    3125                 3130                 3135             


Thr Tyr  Thr Asn Leu Val Val  Gln Leu Ile Arg Asn  Met Glu Ala 
    3140                 3145                 3150             


Glu Ala  Val Ile Asn Glu Arg  Asp Met Glu Glu Leu  Gln Asn Pro 
    3155                 3160                 3165             


Trp Lys  Val Ile Asn Trp Leu  Glu Gly Asn Gly Trp  Asp Arg Leu 
    3170                 3175                 3180             


Arg Ser  Met Ala Val Ser Gly  Asp Asp Cys Val Val  Lys Pro Met 
    3185                 3190                 3195             


Asp Asp  Arg Phe Ala Tyr Ala  Leu Asn Phe Leu Asn  Asp Met Gly 
    3200                 3205                 3210             


Lys Val  Arg Lys Asp Val Gln  Glu Trp Lys Pro Ser  Pro Gly Trp 
    3215                 3220                 3225             


Thr Asn  Trp Glu Glu Val Pro  Phe Cys Ser His His  Phe Asn Lys 
    3230                 3235                 3240             


Leu Pro  Met Lys Asp Gly Arg  Thr Ile Ile Val Pro  Cys Arg His 
    3245                 3250                 3255             


Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Val Ser Pro  Gly Lys Gly 
    3260                 3265                 3270             


Trp Ser  Leu Ser Glu Thr Ala  Cys Leu Gly Lys Ser  Tyr Ala Gln 
    3275                 3280                 3285             


Met Trp  Leu Leu Leu Tyr Phe  His Arg Arg Asp Leu  Arg Leu Met 
    3290                 3295                 3300             


Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val Ser Trp  Val Pro Thr 
    3305                 3310                 3315             


Gly Arg  Thr Thr Trp Ser Ile  His Gly Arg Gly Glu  Trp Met Thr 
    3320                 3325                 3330             


Thr Glu  Asp Met Leu Glu Val  Trp Asn Arg Val Trp  Ile Ile Glu 
    3335                 3340                 3345             


Asn Glu  Tyr Met Glu Asp Lys  Thr Pro Val Thr Glu  Trp Thr Asp 
    3350                 3355                 3360             


Val Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu Trp Cys  Gly Ser Leu 
    3365                 3370                 3375             


Ile Gly  His Arg Pro Arg Ser  Thr Trp Ala Glu Asn  Ile Trp Ala 
    3380                 3385                 3390             


Ala Ile  Tyr Gln Val Arg Arg  Ala Ile Gly Glu Thr  Glu Glu Tyr 
    3395                 3400                 3405             


Arg Asp  Tyr Met Ser Thr Gln  Val Arg Tyr Gly Ser  Glu Glu Gly 
    3410                 3415                 3420             


Pro Ser  Ala Gly Val Leu 
    3425                 


<210>  109
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:88

<400>  109

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Gly Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  110
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:89

<400>  110

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  111
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:90

<400>  111

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  112
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:91

<400>  112

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly Tyr Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  113
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:92

<400>  113

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  114
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:93

<400>  114

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  115
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:94

<400>  115

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  116
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:95

<400>  116

Ile Ser Cys Ile Gly Val Ser Asn Arg Asp Leu Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Glu Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Met 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Leu Ser Asp Met Ala Ser Ala Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asp Lys Gln Ser Asp Thr Gln Ser Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Gly Asp Arg Gly Trp Gly Asn Gly Cys Gly Ile Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ser Lys Phe Thr Cys Cys Lys Lys Met Pro Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Pro Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Ser Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  117
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:96


<220>
<221>  misc_feature
<222>  (152)..(156)
<223>  Xaa can be any naturally occurring amino acid

<400>  117

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Xaa Xaa Xaa Xaa Xaa Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Arg Leu Val Arg Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


Leu Lys Lys 
            


<210>  118
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:97

<400>  118

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Val Cys Thr Ala Ala Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  119
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:98


<220>
<221>  misc_feature
<222>  (156)..(162)
<223>  Xaa can be any naturally occurring amino acid

<400>  119

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Asn Arg Ala Glu Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  120
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:99

<400>  120

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Ala Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  121
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:100

<400>  121

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  122
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:101

<400>  122

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Thr Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Gly 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  123
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:102

<400>  123

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  124
<211>  397
<212>  PRT
<213>  sE of SEQ ID NO:103

<400>  124

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg Ala Lys 
145                 150                 155                 160 


Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
                165                 170                 175     


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
            180                 185                 190         


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
        195                 200                 205             


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
    210                 215                 220                 


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
225                 230                 235                 240 


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
                245                 250                 255     


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
            260                 265                 270         


Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
    290                 295                 300                 


Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val 
305                 310                 315                 320 


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
                325                 330                 335     


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
            340                 345                 350         


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
        355                 360                 365             


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
    370                 375                 380                 


Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser 
385                 390                 395         


<210>  125
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:104

<400>  125

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  126
<211>  397
<212>  PRT
<213>  sE of SEQ ID NO:105

<400>  126

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg Ala Lys 
145                 150                 155                 160 


Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
                165                 170                 175     


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
            180                 185                 190         


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
        195                 200                 205             


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
    210                 215                 220                 


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
225                 230                 235                 240 


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
                245                 250                 255     


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
            260                 265                 270         


Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
    290                 295                 300                 


Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val 
305                 310                 315                 320 


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
                325                 330                 335     


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
            340                 345                 350         


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
        355                 360                 365             


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
    370                 375                 380                 


Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser 
385                 390                 395         


<210>  127
<211>  403
<212>  PRT
<213>  sE of SEQ ID NO:106

<400>  127

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Thr Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser 
            


<210>  128
<211>  404
<212>  PRT
<213>  sE of SEQ ID NO:107

<400>  128

Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Asn 
    50                  55                  60                  


Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val His 
    130                 135                 140                 


Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln His 
145                 150                 155                 160 


Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro Arg 
                165                 170                 175     


Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser Leu 
    210                 215                 220                 


Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr Ala 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly Met 
    290                 295                 300                 


Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro Ser 
305                 310                 315                 320 


Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly Glu 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn Ser 
            340                 345                 350         


Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Glu 
        355                 360                 365             


Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ala 
                


<210>  129
<211>  404
<212>  PRT
<213>  sE of SEQ ID NO:108

<400>  129

Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Asn 
    50                  55                  60                  


Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val His 
    130                 135                 140                 


Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln His 
145                 150                 155                 160 


Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro Arg 
                165                 170                 175     


Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser Leu 
    210                 215                 220                 


Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr Ala 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly Met 
    290                 295                 300                 


Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro Ser 
305                 310                 315                 320 


Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly Glu 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn Ser 
            340                 345                 350         


Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Glu 
        355                 360                 365             


Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ala 
                


<210>  130
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:88 + stem anchor

<400>  130

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Gly Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  131
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:89 + stem anchor

<400>  131

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  132
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:90 + stem anchor

<400>  132

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  133
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:91 + stem anchor

<400>  133

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly Tyr Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  134
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:92 + stem anchor

<400>  134

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  135
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:93 + stem anchor

<400>  135

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Ile Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  136
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:94 + stem anchor

<400>  136

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  137
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:95 + stem anchor

<400>  137

Ile Ser Cys Ile Gly Val Ser Asn Arg Asp Leu Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Glu Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Met 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Leu Ser Asp Met Ala Ser Ala Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asp Lys Gln Ser Asp Thr Gln Ser Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Gly Asp Arg Gly Trp Gly Asn Gly Cys Gly Ile Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ser Lys Phe Thr Cys Cys Lys Lys Met Pro Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Pro Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Ser Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  138
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:96 + stem anchor


<220>
<221>  misc_feature
<222>  (152)..(156)
<223>  Xaa can be any naturally occurring amino acid

<400>  138

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Xaa Xaa Xaa Xaa Xaa Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Arg Leu Val Arg Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


Leu Lys Lys Gly Ser Ser Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  139
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:97 + stem anchor

<400>  139

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Val Cys Thr Ala Ala Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  140
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:98 + stem anchor


<220>
<221>  misc_feature
<222>  (156)..(162)
<223>  Xaa can be any naturally occurring amino acid

<400>  140

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Asn Arg Ala Glu Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  141
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:99 + stem anchor

<400>  141

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Ala Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  142
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:100 + stem anchor

<400>  142

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  143
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:101 + stem anchor

<400>  143

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Thr Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Gly 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  144
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:102 + stem anchor

<400>  144

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  145
<211>  498
<212>  PRT
<213>  E-protein of SEQ ID NO:103 + stem anchor

<400>  145

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg Ala Lys 
145                 150                 155                 160 


Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
                165                 170                 175     


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
            180                 185                 190         


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
        195                 200                 205             


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
    210                 215                 220                 


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
225                 230                 235                 240 


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
                245                 250                 255     


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
            260                 265                 270         


Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
    290                 295                 300                 


Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val 
305                 310                 315                 320 


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
                325                 330                 335     


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
            340                 345                 350         


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
        355                 360                 365             


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
    370                 375                 380                 


Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr 
385                 390                 395                 400 


Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala 
                405                 410                 415     


Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe 
            420                 425                 430         


Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys 
        435                 440                 445             


Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr 
    450                 455                 460                 


Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu 
465                 470                 475                 480 


Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val 
                485                 490                 495     


Ser Ala 
        


<210>  146
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:104 + stem anchor

<400>  146

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Val His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  147
<211>  498
<212>  PRT
<213>  E-protein of SEQ ID NO:105 + stem anchor

<400>  147

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Glu Asn Arg Ala Lys 
145                 150                 155                 160 


Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
                165                 170                 175     


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
            180                 185                 190         


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
        195                 200                 205             


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
    210                 215                 220                 


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
225                 230                 235                 240 


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
                245                 250                 255     


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
            260                 265                 270         


Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
    290                 295                 300                 


Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val 
305                 310                 315                 320 


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
                325                 330                 335     


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
            340                 345                 350         


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
        355                 360                 365             


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
    370                 375                 380                 


Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr 
385                 390                 395                 400 


Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala 
                405                 410                 415     


Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe 
            420                 425                 430         


Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys 
        435                 440                 445             


Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr 
    450                 455                 460                 


Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu 
465                 470                 475                 480 


Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val 
                485                 490                 495     


Ser Ala 
        


<210>  148
<211>  504
<212>  PRT
<213>  E-protein of SEQ ID NO:106 + stem anchor

<400>  148

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Thr Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  149
<211>  505
<212>  PRT
<213>  E-protein of SEQ ID NO:107 + stem anchor

<400>  149

Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Asn 
    50                  55                  60                  


Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val His 
    130                 135                 140                 


Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln His 
145                 150                 155                 160 


Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro Arg 
                165                 170                 175     


Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser Leu 
    210                 215                 220                 


Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr Ala 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly Met 
    290                 295                 300                 


Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro Ser 
305                 310                 315                 320 


Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly Glu 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn Ser 
            340                 345                 350         


Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Glu 
        355                 360                 365             


Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ala Gly Ser Ser Ile Gly Arg Ala Phe Glu Ala Thr Met 
                405                 410                 415     


Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe 
            420                 425                 430         


Gly Ser Val Gly Gly Met Phe Asn Ser Val Gly Lys Phe Val His Gln 
        435                 440                 445             


Val Phe Gly Ser Ala Phe Lys Ala Leu Phe Gly Gly Met Ser Trp Phe 
    450                 455                 460                 


Thr Gln Leu Leu Ile Gly Phe Leu Leu Ile Trp Met Gly Leu Asn Ala 
465                 470                 475                 480 


Arg Gly Gly Thr Val Ala Met Ser Phe Met Gly Ile Gly Ala Met Leu 
                485                 490                 495     


Ile Phe Leu Ala Thr Ser Val Ser Gly 
            500                 505 


<210>  150
<211>  505
<212>  PRT
<213>  E-protein of SEQ ID NO:108 + stem anchor

<400>  150

Ile Arg Cys Ile Gly Ile Gly Asn Arg Asp Phe Ile Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ser Asn Asp Lys Pro Thr Leu Asp Phe Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Ala Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Asn 
    50                  55                  60                  


Ile Ser Glu Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Met Ala Asp Ser Gln Phe Val Cys Lys Arg Gly Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Thr Cys Ala Lys Phe Thr Cys Val Lys Lys Leu Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Val Leu Val Ser Val His 
    130                 135                 140                 


Ala Ser Gln His Gly Gly Met Ile Asn Asn Asp Thr Asn His Gln His 
145                 150                 155                 160 


Asp Lys Glu Asn Arg Ala Arg Ile Asp Ile Thr Ala Ser Ala Pro Arg 
                165                 170                 175     


Val Glu Val Glu Leu Gly Ser Phe Gly Ser Phe Ser Met Glu Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Phe Gly Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Ser Leu 
    210                 215                 220                 


Pro Trp His Thr Gly Ala Thr Ser Asn Asn His His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Arg Glu Ala His Ala Lys Lys Gln Thr Ala 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Ala Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Ser Asp Gly His Lys Ala Thr Ile Tyr Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Leu Asp Lys Leu Arg Leu Lys Gly Met 
    290                 295                 300                 


Ser Tyr Ala Leu Cys Thr Gly Ala Phe Thr Phe Ala Arg Thr Pro Ser 
305                 310                 315                 320 


Glu Thr Ile His Gly Thr Ala Thr Val Glu Leu Gln Tyr Ala Gly Glu 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ile Val Ile Thr Ser Asp Thr Asn Ser 
            340                 345                 350         


Met Ala Ser Thr Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Glu 
        355                 360                 365             


Ser Gly Ala Asn Ser Lys Met Met Val Glu Ile Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Ile Val Gly Thr Gly Thr Thr Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ala Gly Ser Ser Ile Gly Arg Ala Phe Glu Ala Thr Met 
                405                 410                 415     


Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe 
            420                 425                 430         


Gly Ser Val Gly Gly Met Phe Asn Ser Val Gly Lys Phe Val His Gln 
        435                 440                 445             


Val Phe Gly Ser Ala Phe Lys Ala Leu Phe Gly Gly Met Ser Trp Phe 
    450                 455                 460                 


Thr Gln Leu Leu Ile Gly Phe Leu Leu Ile Trp Met Gly Leu Asn Ala 
465                 470                 475                 480 


Arg Gly Gly Thr Val Ala Met Ser Phe Met Gly Ile Gly Ala Met Leu 
                485                 490                 495     


Ile Phe Leu Ala Thr Ser Val Ser Gly 
            500                 505 


<210>  151
<211>  589
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO 61 without N-terminal RR

<400>  151

Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr Ala 
1               5                   10                  15      


Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu 
            20                  25                  30          


Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly 
        35                  40                  45              


Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp 
    50                  55                  60                  


Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro 
65                  70                  75                  80  


Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr 
                85                  90                  95      


Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala 
            100                 105                 110         


Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln 
        115                 120                 125             


Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu 
    130                 135                 140                 


Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile 
145                 150                 155                 160 


Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val 
                165                 170                 175     


Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val 
            180                 185                 190         


Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp 
        195                 200                 205             


Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys 
    210                 215                 220                 


Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala 
225                 230                 235                 240 


Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser 
                245                 250                 255     


Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser 
            260                 265                 270         


Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly 
        275                 280                 285             


Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys 
    290                 295                 300                 


Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn 
305                 310                 315                 320 


Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 
                325                 330                 335     


Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala Lys 
            340                 345                 350         


Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
        355                 360                 365             


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
    370                 375                 380                 


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
385                 390                 395                 400 


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
                405                 410                 415     


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
            420                 425                 430         


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
        435                 440                 445             


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
    450                 455                 460                 


Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg Leu Lys 
465                 470                 475                 480 


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
                485                 490                 495     


Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val 
            500                 505                 510         


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
        515                 520                 525             


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
    530                 535                 540                 


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
545                 550                 555                 560 


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
                565                 570                 575     


Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser 
            580                 585                 


<210>  152
<211>  690
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO 62 without N-terminal RR

<400>  152

Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr Ala 
1               5                   10                  15      


Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu 
            20                  25                  30          


Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly 
        35                  40                  45              


Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp 
    50                  55                  60                  


Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro 
65                  70                  75                  80  


Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr 
                85                  90                  95      


Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala 
            100                 105                 110         


Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln 
        115                 120                 125             


Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu 
    130                 135                 140                 


Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile 
145                 150                 155                 160 


Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val 
                165                 170                 175     


Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val 
            180                 185                 190         


Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp 
        195                 200                 205             


Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys 
    210                 215                 220                 


Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala 
225                 230                 235                 240 


Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser 
                245                 250                 255     


Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser 
            260                 265                 270         


Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly 
        275                 280                 285             


Asn Gly Cys Gly Asp Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys 
    290                 295                 300                 


Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn 
305                 310                 315                 320 


Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 
                325                 330                 335     


Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala Lys 
            340                 345                 350         


Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
        355                 360                 365             


Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 
    370                 375                 380                 


Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 
385                 390                 395                 400 


Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 
                405                 410                 415     


Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 
            420                 425                 430         


Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 
        435                 440                 445             


Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 
    450                 455                 460                 


Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg Leu Lys 
465                 470                 475                 480 


Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 
                485                 490                 495     


Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val 
            500                 505                 510         


Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro 
        515                 520                 525             


Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 
    530                 535                 540                 


Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 
545                 550                 555                 560 


Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 
                565                 570                 575     


Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr 
            580                 585                 590         


Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala 
        595                 600                 605             


Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Ala Leu 
    610                 615                 620                 


Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys 
625                 630                 635                 640 


Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr 
                645                 650                 655     


Leu Leu Met Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu 
            660                 665                 670         


Met Cys Leu Ala Leu Gly Gly Val Leu Ile Phe Leu Ser Thr Ala Val 
        675                 680                 685             


Ser Ala 
    690 


<210>  153
<211>  19800
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pTM3 ATU3-GFP MV Schwarz sequence  + GFP within ATU3

<400>  153
tataagcggc cgctaatacg actcactata gggccaactt tgtttggtct gatgagtccg       60

tgaggacgaa acccggagtc ccgggtcacc aaacaaagtt gggtaaggat agttcaatca      120

atgatcatct tctagtgcac ttaggattca agatcctatt atcagggaca agagcaggat      180

tagggatatc cgagatggcc acacttttaa ggagcttagc attgttcaaa agaaacaagg      240

acaaaccacc cattacatca ggatccggtg gagccatcag aggaatcaaa cacattatta      300

tagtaccaat ccctggagat tcctcaatta ccactcgatc cagacttctg gaccggttgg      360

tgaggttaat tggaaacccg gatgtgagcg ggcccaaact aacaggggca ctaataggta      420

tattatcctt atttgtggag tctccaggtc aattgattca gaggatcacc gatgaccctg      480

acgttagcat aaggctgtta gaggttgtcc agagtgacca gtcacaatct ggccttacct      540

tcgcatcaag aggtaccaac atggaggatg aggcggacca atacttttca catgatgatc      600

caattagtag tgatcaatcc aggttcggat ggttcgggaa caaggaaatc tcagatattg      660

aagtgcaaga ccctgaggga ttcaacatga ttctgggtac catcctagcc caaatttggg      720

tcttgctcgc aaaggcggtt acggccccag acacggcagc tgattcggag ctaagaaggt      780

ggataaagta cacccaacaa agaagggtag ttggtgaatt tagattggag agaaaatggt      840

tggatgtggt gaggaacagg attgccgagg acctctcctt acgccgattc atggtcgctc      900

taatcctgga tatcaagaga acacccggaa acaaacccag gattgctgaa atgatatgtg      960

acattgatac atatatcgta gaggcaggat tagccagttt tatcctgact attaagtttg     1020

ggatagaaac tatgtatcct gctcttggac tgcatgaatt tgctggtgag ttatccacac     1080

ttgagtcctt gatgaacctt taccagcaaa tgggggaaac tgcaccctac atggtaatcc     1140

tggagaactc aattcagaac aagttcagtg caggatcata ccctctgctc tggagctatg     1200

ccatgggagt aggagtggaa cttgaaaact ccatgggagg tttgaacttt ggccgatctt     1260

actttgatcc agcatatttt agattagggc aagagatggt aaggaggtca gctggaaagg     1320

tcagttccac attggcatct gaactcggta tcactgccga ggatgcaagg cttgtttcag     1380

agattgcaat gcatactact gaggacaaga tcagtagagc ggttggaccc agacaagccc     1440

aagtatcatt tctacacggt gatcaaagtg agaatgagct accgagattg gggggcaagg     1500

aagataggag ggtcaaacag agtcgaggag aagccaggga gagctacaga gaaaccgggc     1560

ccagcagagc aagtgatgcg agagctgccc atcttccaac cggcacaccc ctagacattg     1620

acactgcaac ggagtccagc caagatccgc aggacagtcg aaggtcagct gacgccctgc     1680

ttaggctgca agccatggca ggaatctcgg aagaacaagg ctcagacacg gacaccccta     1740

tagtgtacaa tgacagaaat cttctagact aggtgcgaga ggccgagggc cagaacaaca     1800

tccgcctacc atccatcatt gttataaaaa acttaggaac caggtccaca cagccgccag     1860

cccatcaacc atccactccc acgattggag ccaatggcag aagagcaggc acgccatgtc     1920

aaaaacggac tggaatgcat ccgggctctc aaggccgagc ccatcggctc actggccatc     1980

gaggaagcta tggcagcatg gtcagaaata tcagacaacc caggacagga gcgagccacc     2040

tgcagggaag agaaggcagg cagttcgggt ctcagcaaac catgcctctc agcaattgga     2100

tcaactgaag gcggtgcacc tcgcatccgc ggtcagggac ctggagagag cgatgacgac     2160

gctgaaactt tgggaatccc cccaagaaat ctccaggcat caagcactgg gttacagtgt     2220

tattacgttt atgatcacag cggtgaagcg gttaagggaa tccaagatgc tgactctatc     2280

atggttcaat caggccttga tggtgatagc accctctcag gaggagacaa tgaatctgaa     2340

aacagcgatg tggatattgg cgaacctgat accgagggat atgctatcac tgaccgggga     2400

tctgctccca tctctatggg gttcagggct tctgatgttg aaactgcaga aggaggggag     2460

atccacgagc tcctgagact ccaatccaga ggcaacaact ttccgaagct tgggaaaact     2520

ctcaatgttc ctccgccccc ggaccccggt agggccagca cttccgggac acccattaaa     2580

aagggcacag acgcgagatt agcctcattt ggaacggaga tcgcgtcttt attgacaggt     2640

ggtgcaaccc aatgtgctcg aaagtcaccc tcggaaccat cagggccagg tgcacctgcg     2700

gggaatgtcc ccgagtgtgt gagcaatgcc gcactgatac aggagtggac acccgaatct     2760

ggtaccacaa tctccccgag atcccagaat aatgaagaag ggggagacta ttatgatgat     2820

gagctgttct ctgatgtcca agatattaaa acagccttgg ccaaaataca cgaggataat     2880

cagaagataa tctccaagct agaatcactg ctgttattga agggagaagt tgagtcaatt     2940

aagaagcaga tcaacaggca aaatatcagc atatccaccc tggaaggaca cctctcaagc     3000

atcatgatcg ccattcctgg acttgggaag gatcccaacg accccactgc agatgtcgaa     3060

atcaatcccg acttgaaacc catcataggc agagattcag gccgagcact ggccgaagtt     3120

ctcaagaaac ccgttgccag ccgacaactc caaggaatga caaatggacg gaccagttcc     3180

agaggacagc tgctgaagga atttcagcta aagccgatcg ggaaaaagat gagctcagcc     3240

gtcgggtttg ttcctgacac cggccctgca tcacgcagtg taatccgctc cattataaaa     3300

tccagccggc tagaggagga tcggaagcgt tacctgatga ctctccttga tgatatcaaa     3360

ggagccaatg atcttgccaa gttccaccag atgctgatga agataataat gaagtagcta     3420

cagctcaact tacctgccaa ccccatgcca gtcgacccaa ctagtacaac ctaaatccat     3480

tataaaaaac ttaggagcaa agtgattgcc tcccaaggtc cacaatgaca gagacctacg     3540

acttcgacaa gtcggcatgg gacatcaaag ggtcgatcgc tccgatacaa cccaccacct     3600

acagtgatgg caggctggtg ccccaggtca gagtcataga tcctggtcta ggcgacagga     3660

aggatgaatg ctttatgtac atgtttctgc tgggggttgt tgaggacagc gattccctag     3720

ggcctccaat cgggcgagca tttgggttcc tgcccttagg tgttggcaga tccacagcaa     3780

agcccgaaaa actcctcaaa gaggccactg agcttgacat agttgttaga cgtacagcag     3840

ggctcaatga aaaactggtg ttctacaaca acaccccact aactctcctc acaccttgga     3900

gaaaggtcct aacaacaggg agtgtcttca acgcaaacca agtgtgcaat gcggttaatc     3960

tgataccgct cgataccccg cagaggttcc gtgttgttta tatgagcatc acccgtcttt     4020

cggataacgg gtattacacc gttcctagaa gaatgctgga attcagatcg gtcaatgcag     4080

tggccttcaa cctgctggtg acccttagga ttgacaaggc gataggccct gggaagatca     4140

tcgacaatac agagcaactt cctgaggcaa catttatggt ccacatcggg aacttcagga     4200

gaaagaagag tgaagtctac tctgccgatt attgcaaaat gaaaatcgaa aagatgggcc     4260

tggtttttgc acttggtggg atagggggca ccagtcttca cattagaagc acaggcaaaa     4320

tgagcaagac tctccatgca caactcgggt tcaagaagac cttatgttac ccgctgatgg     4380

atatcaatga agaccttaat cgattactct ggaggagcag atgcaagata gtaagaatcc     4440

aggcagtttt gcagccatca gttcctcaag aattccgcat ttacgacgac gtgatcataa     4500

atgatgacca aggactattc aaagttctgt agaccgtagt gcccagcaat gcccgaaaac     4560

gacccccctc acaatgacag ccagaaggcc cggacaaaaa agccccctcc gaaagactcc     4620

acggaccaag cgagaggcca gccagcagcc gacggcaagc gcgaacacca ggcggcccca     4680

gcacagaaca gccctgacac aaggccacca ccagccaccc caatctgcat cctcctcgtg     4740

ggacccccga ggaccaaccc ccaaggctgc ccccgatcca aaccaccaac cgcatcccca     4800

ccacccccgg gaaagaaacc cccagcaatt ggaaggcccc tccccctctt cctcaacaca     4860

agaactccac aaccgaaccg cacaagcgac cgaggtgacc caaccgcagg catccgactc     4920

cctagacaga tcctctctcc ccggcaaact aaacaaaact tagggccaag gaacatacac     4980

acccaacaga acccagaccc cggcccacgg cgccgcgccc ccaacccccg acaaccagag     5040

ggagccccca accaatcccg ccggctcccc cggtgcccac aggcagggac accaaccccc     5100

gaacagaccc agcacccaac catcgacaat ccaagacggg ggggcccccc caaaaaaagg     5160

cccccagggg ccgacagcca gcaccgcgag gaagcccacc caccccacac acgaccacgg     5220

caaccaaacc agaacccaga ccaccctggg ccaccagctc ccagactcgg ccatcacccc     5280

gcagaaagga aaggccacaa cccgcgcacc ccagccccga tccggcgggg agccacccaa     5340

cccgaaccag cacccaagag cgatccccga aggacccccg aaccgcaaag gacatcagta     5400

tcccacagcc tctccaagtc ccccggtctc ctcctcttct cgaagggacc aaaagatcaa     5460

tccaccacac ccgacgacac tcaactcccc acccctaaag gagacaccgg gaatcccaga     5520

atcaagactc atccaatgtc catcatgggt ctcaaggtga acgtctctgc catattcatg     5580

gcagtactgt taactctcca aacacccacc ggtcaaatcc attggggcaa tctctctaag     5640

ataggggtgg taggaatagg aagtgcaagc tacaaagtta tgactcgttc cagccatcaa     5700

tcattagtca taaaattaat gcccaatata actctcctca ataactgcac gagggtagag     5760

attgcagaat acaggagact actgagaaca gttttggaac caattagaga tgcacttaat     5820

gcaatgaccc agaatataag accggttcag agtgtagctt caagtaggag acacaagaga     5880

tttgcgggag tagtcctggc aggtgcggcc ctaggcgttg ccacagctgc tcagataaca     5940

gccggcattg cacttcacca gtccatgctg aactctcaag ccatcgacaa tctgagagcg     6000

agcctggaaa ctactaatca ggcaattgag acaatcagac aagcagggca ggagatgata     6060

ttggctgttc agggtgtcca agactacatc aataatgagc tgataccgtc tatgaaccaa     6120

ctatcttgtg atttaatcgg ccagaagctc gggctcaaat tgctcagata ctatacagaa     6180

atcctgtcat tatttggccc cagtttacgg gaccccatat ctgcggagat atctatccag     6240

gctttgagct atgcgcttgg aggagacatc aataaggtgt tagaaaagct cggatacagt     6300

ggaggtgatt tactgggcat cttagagagc ggaggaataa aggcccggat aactcacgtc     6360

gacacagagt cctacttcat tgtcctcagt atagcctatc cgacgctgtc cgagattaag     6420

ggggtgattg tccaccggct agagggggtc tcgtacaaca taggctctca agagtggtat     6480

accactgtgc ccaagtatgt tgcaacccaa gggtacctta tctcgaattt tgatgagtca     6540

tcgtgtactt tcatgccaga ggggactgtg tgcagccaaa atgccttgta cccgatgagt     6600

cctctgctcc aagaatgcct ccgggggtac accaagtcct gtgctcgtac actcgtatcc     6660

gggtcttttg ggaaccggtt cattttatca caagggaacc taatagccaa ttgtgcatca     6720

atcctttgca agtgttacac aacaggaacg atcattaatc aagaccctga caagatccta     6780

acatacattg ctgccgatca ctgcccggta gtcgaggtga acggcgtgac catccaagtc     6840

gggagcagga ggtatccaga cgctgtgtac ttgcacagaa ttgacctcgg tcctcccata     6900

tcattggaga ggttggacgt agggacaaat ctggggaatg caattgctaa gttggaggat     6960

gccaaggaat tgttggagtc atcggaccag atattgagga gtatgaaagg tttatcgagc     7020

actagcatag tctacatcct gattgcagtg tgtcttggag ggttgatagg gatccccgct     7080

ttaatatgtt gctgcagggg gcgttgtaac aaaaagggag aacaagttgg tatgtcaaga     7140

ccaggcctaa agcctgatct tacgggaaca tcaaaatcct atgtaaggtc gctctgatcc     7200

tctacaactc ttgaaacaca aatgtcccac aagtctcctc ttcgtcatca agcaaccacc     7260

gcacccagca tcaagcccac ctgaaattat ctccggcttc cctctggccg aacaatatcg     7320

gtagttaatc aaaacttagg gtgcaagatc atccacaatg tcaccacaac gagaccggat     7380

aaatgccttc tacaaagata acccccatcc caagggaagt aggatagtca ttaacagaga     7440

acatcttatg attgatagac cttatgtttt gctggctgtt ctgtttgtca tgtttctgag     7500

cttgatcggg ttgctagcca ttgcaggcat tagacttcat cgggcagcca tctacaccgc     7560

agagatccat aaaagcctca gcaccaatct agatgtaact aactcaatcg agcatcaggt     7620

caaggacgtg ctgacaccac tcttcaaaat catcggtgat gaagtgggcc tgaggacacc     7680

tcagagattc actgacctag tgaaattaat ctctgacaag attaaattcc ttaatccgga     7740

tagggagtac gacttcagag atctcacttg gtgtatcaac ccgccagaga gaatcaaatt     7800

ggattatgat caatactgtg cagatgtggc tgctgaagag ctcatgaatg cattggtgaa     7860

ctcaactcta ctggagacca gaacaaccaa tcagttccta gctgtctcaa agggaaactg     7920

ctcagggccc actacaatca gaggtcaatt ctcaaacatg tcgctgtccc tgttagactt     7980

gtatttaggt cgaggttaca atgtgtcatc tatagtcact atgacatccc agggaatgta     8040

tgggggaact tacctagtgg aaaagcctaa tctgagcagc aaaaggtcag agttgtcaca     8100

actgagcatg taccgagtgt ttgaagtagg tgttatcaga aatccgggtt tgggggctcc     8160

ggtgttccat atgacaaact atcttgagca accagtcagt aatgatctca gcaactgtat     8220

ggtggctttg ggggagctca aactcgcagc cctttgtcac ggggaagatt ctatcacaat     8280

tccctatcag ggatcaggga aaggtgtcag cttccagctc gtcaagctag gtgtctggaa     8340

atccccaacc gacatgcaat cctgggtccc cttatcaacg gatgatccag tgatagacag     8400

gctttacctc tcatctcaca gaggtgttat cgctgacaat caagcaaaat gggctgtccc     8460

gacaacacga acagatgaca agttgcgaat ggagacatgc ttccaacagg cgtgtaaggg     8520

taaaatccaa gcactctgcg agaatcccga gtgggcacca ttgaaggata acaggattcc     8580

ttcatacggg gtcttgtctg ttgatctgag tctgacagtt gagcttaaaa tcaaaattgc     8640

ttcgggattc gggccattga tcacacacgg ttcagggatg gacctataca aatccaacca     8700

caacaatgtg tattggctga ctatcccgcc aatgaagaac ctagccttag gtgtaatcaa     8760

cacattggag tggataccga gattcaaggt tagtccctac ctcttcactg tcccaattaa     8820

ggaagcaggc gaagactgcc atgccccaac atacctacct gcggaggtgg atggtgatgt     8880

caaactcagt tccaatctgg tgattctacc tggtcaagat ctccaatatg ttttggcaac     8940

ctacgatact tccagggttg aacatgctgt ggtttattac gtttacagcc caagccgctc     9000

attttcttac ttttatcctt ttaggttgcc tataaagggg gtccccatcg aattacaagt     9060

ggaatgcttc acatgggacc aaaaactctg gtgccgtcac ttctgtgtgc ttgcggactc     9120

agaatctggt ggacatatca ctcactctgg gatggtgggc atgggagtca gctgcacagt     9180

cacccgggaa gatggaacca atcgcagata gggctgctag tgaaccaatc acatgatgtc     9240

acccagacat caggcatacc cactagtcta ccctccatca ttgttataaa aaacttagga     9300

accaggtcca cacagccgcc agcccatcaa cgcgtacgat ggtgagcaag ggcgaggagc     9360

tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt     9420

tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca     9480

tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg     9540

gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg     9600

ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca     9660

agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg     9720

gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca     9780

gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga     9840

tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc     9900

ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc     9960

tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg    10020

ccgggatcac tctcggcatg gacgagctgt acaagtaggc gcgcagcgct tagacgtctc    10080

gcgatcgatg ctagtgtgaa atagacatca gaattaagaa aaacgtaggg tccaagtggt    10140

tccccgttat ggactcgcta tctgtcaacc agatcttata ccctgaagtt cacctagata    10200

gcccgatagt taccaataag atagtagcca tcctggagta tgctcgagtc cctcacgctt    10260

acagcctgga ggaccctaca ctgtgtcaga acatcaagca ccgcctaaaa aacggatttt    10320

ccaaccaaat gattataaac aatgtggaag ttgggaatgt catcaagtcc aagcttagga    10380

gttatccggc ccactctcat attccatatc caaattgtaa tcaggattta tttaacatag    10440

aagacaaaga gtcaacgagg aagatccgtg aactcctcaa aaaggggaat tcgctgtact    10500

ccaaagtcag tgataaggtt ttccaatgct taagggacac taactcacgg cttggcctag    10560

gctccgaatt gagggaggac atcaaggaga aagttattaa cttgggagtt tacatgcaca    10620

gctcccagtg gtttgagccc tttctgtttt ggtttacagt caagactgag atgaggtcag    10680

tgattaaatc acaaacccat acttgccata ggaggagaca cacacctgta ttcttcactg    10740

gtagttcagt tgagttgcta atctctcgtg accttgttgc tataatcagt aaagagtctc    10800

aacatgtata ttacctgaca tttgaactgg ttttgatgta ttgtgatgtc atagagggga    10860

ggttaatgac agagaccgct atgactattg atgctaggta tacagagctt ctaggaagag    10920

tcagatacat gtggaaactg atagatggtt tcttccctgc actcgggaat ccaacttatc    10980

aaattgtagc catgctggag cctctttcac ttgcttacct gcagctgagg gatataacag    11040

tagaactcag aggtgctttc cttaaccact gctttactga aatacatgat gttcttgacc    11100

aaaacgggtt ttctgatgaa ggtacttatc atgagttaac tgaagctcta gattacattt    11160

tcataactga tgacatacat ctgacagggg agattttctc atttttcaga agtttcggcc    11220

accccagact tgaagcagta acggctgctg aaaatgttag gaaatacatg aatcagccta    11280

aagtcattgt gtatgagact ctgatgaaag gtcatgccat attttgtgga atcataatca    11340

acggctatcg tgacaggcac ggaggcagtt ggccaccgct gaccctcccc ctgcatgctg    11400

cagacacaat ccggaatgct caagcttcag gtgaagggtt aacacatgag cagtgcgttg    11460

ataactggaa atcttttgct ggagtgaaat ttggctgctt tatgcctctt agcctggata    11520

gtgatctgac aatgtaccta aaggacaagg cacttgctgc tctccaaagg gaatgggatt    11580

cagtttaccc gaaagagttc ctgcgttacg accctcccaa gggaaccggg tcacggaggc    11640

ttgtagatgt tttccttaat gattcgagct ttgacccata tgatgtgata atgtatgttg    11700

taagtggagc ttacctccat gaccctgagt tcaacctgtc ttacagcctg aaagaaaagg    11760

agatcaagga aacaggtaga ctttttgcta aaatgactta caaaatgagg gcatgccaag    11820

tgattgctga aaatctaatc tcaaacggga ttggcaaata ttttaaggac aatgggatgg    11880

ccaaggatga gcacgatttg actaaggcac tccacactct agctgtctca ggagtcccca    11940

aagatctcaa agaaagtcac aggggggggc cagtcttaaa aacctactcc cgaagcccag    12000

tccacacaag taccaggaac gtgagagcag caaaagggtt tatagggttc cctcaagtaa    12060

ttcggcagga ccaagacact gatcatccgg agaatatgga agcttacgag acagtcagtg    12120

catttatcac gactgatctc aagaagtact gccttaattg gagatatgag accatcagct    12180

tgtttgcaca gaggctaaat gagatttacg gattgccctc atttttccag tggctgcata    12240

agaggcttga gacctctgtc ctgtatgtaa gtgaccctca ttgccccccc gaccttgacg    12300

cccatatccc gttatataaa gtccccaatg atcaaatctt cattaagtac cctatgggag    12360

gtatagaagg gtattgtcag aagctgtgga ccatcagcac cattccctat ctatacctgg    12420

ctgcttatga gagcggagta aggattgctt cgttagtgca aggggacaat cagaccatag    12480

ccgtaacaaa aagggtaccc agcacatggc cctacaacct taagaaacgg gaagctgcta    12540

gagtaactag agattacttt gtaattctta ggcaaaggct acatgatatt ggccatcacc    12600

tcaaggcaaa tgagacaatt gtttcatcac atttttttgt ctattcaaaa ggaatatatt    12660

atgatgggct acttgtgtcc caatcactca agagcatcgc aagatgtgta ttctggtcag    12720

agactatagt tgatgaaaca agggcagcat gcagtaatat tgctacaaca atggctaaaa    12780

gcatcgagag aggttatgac cgttaccttg catattccct gaacgtccta aaagtgatac    12840

agcaaattct gatctctctt ggcttcacaa tcaattcaac catgacccgg gatgtagtca    12900

tacccctcct cacaaacaac gacctcttaa taaggatggc actgttgccc gctcctattg    12960

gggggatgaa ttatctgaat atgagcaggc tgtttgtcag aaacatcggt gatccagtaa    13020

catcatcaat tgctgatctc aagagaatga ttctcgcctc actaatgcct gaagagaccc    13080

tccatcaagt aatgacacaa caaccggggg actcttcatt cctagactgg gctagcgacc    13140

cttactcagc aaatcttgta tgtgtccaga gcatcactag actcctcaag aacataactg    13200

caaggtttgt cctgatccat agtccaaacc caatgttaaa aggattattc catgatgaca    13260

gtaaagaaga ggacgaggga ctggcggcat tcctcatgga caggcatatt atagtaccta    13320

gggcagctca tgaaatcctg gatcatagtg tcacaggggc aagagagtct attgcaggca    13380

tgctggatac cacaaaaggc ttgattcgag ccagcatgag gaaggggggg ttaacctctc    13440

gagtgataac cagattgtcc aattatgact atgaacaatt cagagcaggg atggtgctat    13500

tgacaggaag aaagagaaat gtcctcattg acaaagagtc atgttcagtg cagctggcga    13560

gagctctaag aagccatatg tgggcgaggc tagctcgagg acggcctatt tacggccttg    13620

aggtccctga tgtactagaa tctatgcgag gccaccttat tcggcgtcat gagacatgtg    13680

tcatctgcga gtgtggatca gtcaactacg gatggttttt tgtcccctcg ggttgccaac    13740

tggatgatat tgacaaggaa acatcatcct tgagagtccc atatattggt tctaccactg    13800

atgagagaac agacatgaag cttgccttcg taagagcccc aagtcgatcc ttgcgatctg    13860

ctgttagaat agcaacagtg tactcatggg cttacggtga tgatgatagc tcttggaacg    13920

aagcctggtt gttggctagg caaagggcca atgtgagcct ggaggagcta agggtgatca    13980

ctcccatctc aacttcgact aatttagcgc ataggttgag ggatcgtagc actcaagtga    14040

aatactcagg tacatccctt gtccgagtgg cgaggtatac cacaatctcc aacgacaatc    14100

tctcatttgt catatcagat aagaaggttg atactaactt tatataccaa caaggaatgc    14160

ttctagggtt gggtgtttta gaaacattgt ttcgactcga gaaagatacc ggatcatcta    14220

acacggtatt acatcttcac gtcgaaacag attgttgcgt gatcccgatg atagatcatc    14280

ccaggatacc cagctcccgc aagctagagc tgagggcaga gctatgtacc aacccattga    14340

tatatgataa tgcaccttta attgacagag atgcaacaag gctatacacc cagagccata    14400

ggaggcacct tgtggaattt gttacatggt ccacacccca actatatcac attttagcta    14460

agtccacagc actatctatg attgacctgg taacaaaatt tgagaaggac catatgaatg    14520

aaatttcagc tctcataggg gatgacgata tcaatagttt cataactgag tttctgctca    14580

tagagccaag attattcact atctacttgg gccagtgtgc ggccatcaat tgggcatttg    14640

atgtacatta tcatagacca tcagggaaat atcagatggg tgagctgttg tcatcgttcc    14700

tttctagaat gagcaaagga gtgtttaagg tgcttgtcaa tgctctaagc cacccaaaga    14760

tctacaagaa attctggcat tgtggtatta tagagcctat ccatggtcct tcacttgatg    14820

ctcaaaactt gcacacaact gtgtgcaaca tggtttacac atgctatatg acctacctcg    14880

acctgttgtt gaatgaagag ttagaagagt tcacatttct cttgtgtgaa agcgacgagg    14940

atgtagtacc ggacagattc gacaacatcc aggcaaaaca cttatgtgtt ctggcagatt    15000

tgtactgtca accagggacc tgcccaccaa ttcgaggtct aagaccggta gagaaatgtg    15060

cagttctaac cgaccatatc aaggcagagg ctatgttatc tccagcagga tcttcgtgga    15120

acataaatcc aattattgta gaccattact catgctctct gacttatctc cggcgaggat    15180

cgatcaaaca gataagattg agagttgatc caggattcat tttcgacgcc ctcgctgagg    15240

taaatgtcag tcagccaaag atcggcagca acaacatctc aaatatgagc atcaaggctt    15300

tcagaccccc acacgatgat gttgcaaaat tgctcaaaga tatcaacaca agcaagcaca    15360

atcttcccat ttcagggggc aatctcgcca attatgaaat ccatgctttc cgcagaatcg    15420

ggttgaactc atctgcttgc tacaaagctg ttgagatatc aacattaatt aggagatgcc    15480

ttgagccagg ggaggacggc ttgttcttgg gtgagggatc gggttctatg ttgatcactt    15540

ataaagagat acttaaacta aacaagtgct tctataatag tggggtttcc gccaattcta    15600

gatctggtca aagggaatta gcaccctatc cctccgaagt tggccttgtc gaacacagaa    15660

tgggagtagg taatattgtc aaagtgctct ttaacgggag gcccgaagtc acgtgggtag    15720

gcagtgtaga ttgcttcaat ttcatagtta gtaatatccc tacctctagt gtggggttta    15780

tccattcaga tatagagacc ttgcctgaca aagatactat agagaagcta gaggaattgg    15840

cagccatctt atcgatggct ctgctcctgg gcaaaatagg atcaatactg gtgattaagc    15900

ttatgccttt cagcggggat tttgttcagg gatttataag ttatgtaggg tctcattata    15960

gagaagtgaa ccttgtatac cctagataca gcaacttcat ctctactgaa tcttatttgg    16020

ttatgacaga tctcaaggct aaccggctaa tgaatcctga aaagattaag cagcagataa    16080

ttgaatcatc tgtgaggact tcacctggac ttataggtca catcctatcc attaagcaac    16140

taagctgcat acaagcaatt gtgggagacg cagttagtag aggtgatatc aatcctactc    16200

tgaaaaaact tacacctata gagcaggtgc tgatcaattg cgggttggca attaacggac    16260

ctaagctgtg caaagaattg atccaccatg atgttgcctc agggcaagat ggattgctta    16320

attctatact catcctctac agggagttgg caagattcaa agacaaccaa agaagtcaac    16380

aagggatgtt ccacgcttac cccgtattgg taagtagcag gcaacgagaa cttatatcta    16440

ggatcacccg caaattctgg gggcacattc ttctttactc cgggaacaaa aagttgataa    16500

ataagtttat ccagaatctc aagtccggct atctgatact agacttacac cagaatatct    16560

tcgttaagaa tctatccaag tcagagaaac agattattat gacggggggt ttgaaacgtg    16620

agtgggtttt taaggtaaca gtcaaggaga ccaaagaatg gtataagtta gtcggataca    16680

gtgccctgat taaggactaa ttggttgaac tccggaaccc taatcctgcc ctaggtggtt    16740

aggcattatt tgcaatatat taaagaaaac tttgaaaata cgaagtttct attcccagct    16800

ttgtctggtg gccggcatgg tcccagcctc ctcgctggcg ccggctgggc aacattccga    16860

ggggaccgtc ccctcggtaa tggcgaatgg gacgcggccg atccggctgc taacaaagcc    16920

cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata accccttggg    16980

gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc cggatgcggc    17040

cgcgggccct atggtaccca gcttttgttc cctttagtga gggttaattc cgagcttggc    17100

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa    17160

cataggagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga ggtaactcac    17220

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca    17280

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc    17340

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc    17400

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc    17460

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag    17520

gctcggcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc    17580

gacaggacta taaagatacc aggcgttccc ccctggaagc tccctcgtgc gctctcctgt    17640

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct    17700

ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg    17760

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct    17820

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat    17880

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg    17940

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa    18000

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt    18060

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc    18120

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt    18180

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta    18240

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat    18300

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctgcccgtcg tgtagataac    18360

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg    18420

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag    18480

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt    18540

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt    18600

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt    18660

tacatgatcc cccatgttgt gaaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt    18720

cagaagtaag ttggccgcag tgttatcact catgcttatg gcagcactgc ataattctct    18780

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt    18840

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac    18900

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa    18960

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa    19020

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca    19080

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct    19140

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga    19200

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc    19260

tgaaattgta aacgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc    19320

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    19380

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    19440

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    19500

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    19560

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    19620

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    19680

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    19740

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc caccgcggtg    19800


<210>  154
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Kozak sequence

<400>  154
gccaccatgg                                                              10


<210>  155
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Kozak sequence + alanine after start codon

<400>  155
gccaccatgg ca                                                           12


<210>  156
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enhanced honeybee melittin signal peptide

<400>  156
atgaaattct tagtcaacgt tgcccttgtt tttatggtcg tatacatttc ttacatctat       60

gcg                                                                     63


<210>  157
<211>  19
<212>  PRT
<213>  Homo sapiens azurocidin signal peptide

<400>  157

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  158
<211>  18
<212>  PRT
<213>  Homo sapiens serum albumin signal peptide

<400>  158

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  159
<211>  23
<212>  PRT
<213>  Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 1 signal peptide

<400>  159

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala 
            20              


<210>  160
<211>  30
<212>  PRT
<213>  Bos taurus prolactin signal peptide

<400>  160

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210>  161
<211>  58
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (strain Armstrong), pre-glycoprotein polyprotein GP complex signal peptide

<400>  161

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Val Ile Thr Gly Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Phe Ala Leu Ile Ser 
        35                  40                  45              


Phe Leu Leu Leu Ala Gly Arg Ser Cys Gly 
    50                  55              


<210>  162
<211>  27
<212>  PRT
<213>  Homo sapiens insulin receptor signal peptide

<400>  162

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly 
            20                  25          


<210>  163
<211>  20
<212>  PRT
<213>  Drosophila melanogaster BM-40 signal peptide

<400>  163

Met Arg Ser Leu Trp Leu Leu Leu Gly Leu Gly Leu Leu Ala Val Ser 
1               5                   10                  15      


His Val Gln Ala 
            20  


<210>  164
<211>  16
<212>  PRT
<213>  Vesicular stomatitis virus Glycoprotein protein signal peptide

<400>  164

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


<210>  165
<211>  18
<212>  PRT
<213>  Homo sapiens Chymotrypsinogen B signal peptide

<400>  165

Met Ala Ser Leu Trp Leu Leu Ser Cys Phe Ser Leu Val Gly Ala Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  166
<211>  20
<212>  PRT
<213>  Homo sapiens Interleukin-2 signal peptide

<400>  166

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  167
<211>  17
<212>  PRT
<213>  Gaussia princeps Luciferase signal peptide

<400>  167

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  168
<211>  19
<212>  PRT
<213>  Gaussia princeps Gluc Luciferase signal peptide

<400>  168

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Val Thr Gly 
            


<210>  169
<211>  17
<212>  PRT
<213>  Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) Hemagglutinin (HA) signal peptide

<400>  169

Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala 
    


<210>  170
<211>  15
<212>  PRT
<213>  Influenza A virus (strain A/Japan/305/1957 H2N2) Hemagglutinin (HA)  signal peptide

<400>  170

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly 
1               5                   10                  15  


<210>  171
<211>  16
<212>  PRT
<213>  Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd) Hemagglutinin signal peptide

<400>  171

Met Glu Lys Thr Val Leu Leu Leu Ala Thr Val Ser Leu Val Lys Ser 
1               5                   10                  15      


<210>  172
<211>  21
<212>  PRT
<213>  Hepatitis C Virus (HCV) 1b E1 signal peptide

<400>  172

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Thr Pro Ala Ser 
            20      


<210>  173
<211>  20
<212>  PRT
<213>  Hepatitis C Virus 1b E2 signal peptide

<400>  173

Met Val Gly Asn Trp Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala 
1               5                   10                  15      


Gly Val Asp Gly 
            20  


<210>  174
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide based on HCV 1b

<400>  174

Met Asp Ala Met Lys Val Leu Leu Leu Val Phe Val Ser Pro Ser Gln 
1               5                   10                  15      


Val Thr Gly 
            


<210>  175
<211>  22
<212>  PRT
<213>  Homo sapiens Tissue-type plasminogen activator signal peptide 1

<400>  175

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro 
            20          


<210>  176
<211>  25
<212>  PRT
<213>  Homo sapiens Tissue-type plasminogen activator signal peptide 2

<400>  176

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Asp Ser Val Thr Gly 
            20                  25  


<210>  177
<211>  26
<212>  PRT
<213>  Murray Valley encephalitis (MVE) virus prM signal peptide

<400>  177

Lys Lys Arg Gly Gly Ser Glu Thr Ser Val Leu Met Leu Ile Phe Met 
1               5                   10                  15      


Leu Ile Gly Phe Ala Ala Ala Leu Lys Leu 
            20                  25      


<210>  178
<211>  26
<212>  PRT
<213>  Yellow fever virus signal peptide

<400>  178

Lys Arg Arg Ser His Asp Val Leu Thr Val Gln Phe Leu Ile Leu Gly 
1               5                   10                  15      


Met Leu Leu Met Thr Gly Gly Val Thr Leu 
            20                  25      


<210>  179
<211>  24
<212>  PRT
<213>  Kunjin virus signal peptide

<400>  179

Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala Phe Met Ile Gly Leu Ile 
1               5                   10                  15      


Ala Gly Val Gly Ala Val Thr Leu 
            20                  


<210>  180
<211>  26
<212>  PRT
<213>  Tick-borne encephalitis virus signal peptide

<400>  180

Lys Arg Arg Ser Ala Thr Asp Trp Met Ser Trp Leu Leu Val Ile Thr 
1               5                   10                  15      


Leu Leu Gly Met Thr Leu Ala Ala Thr Val 
            20                  25      


<210>  181
<211>  20
<212>  PRT
<213>  Dengue virus signal peptide

<400>  181

Arg Arg Arg Thr Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met 
1               5                   10                  15      


Ala Phe His Leu 
            20  


<210>  182
<211>  24
<212>  PRT
<213>  West Nile virus signal peptide

<400>  182

Lys Lys Arg Gly Gly Thr Ala Gly Phe Thr Ile Leu Leu Gly Leu Ile 
1               5                   10                  15      


Ala Cys Ala Gly Ala Val Thr Leu 
            20                  


<210>  183
<211>  28
<212>  PRT
<213>  Japanese encephalitis signal peptide 1

<400>  183

Asn Lys Arg Gly Gly Asn Glu Gly Ser Ile Met Trp Leu Ala Ser Leu 
1               5                   10                  15      


Ala Val Val Ile Ala Tyr Ala Gly Ala Met Lys Leu 
            20                  25              


<210>  184
<211>  24
<212>  PRT
<213>  Japanese encephalitis SA-14 JE isolate (GenBank accession # M55506) signal peptide 2

<400>  184

Met Gly Lys Arg Ser Ala Gly Ser Ile Met Trp Leu Ala Ser Leu Ala 
1               5                   10                  15      


Val Val Ile Ala Cys Ala Gly Ala 
            20                  


<210>  185
<211>  56
<212>  PRT
<213>  Tick-borne encephalitis virus stem anchor sequence

<400>  185

Lys Gly Ser Ser Ile Gly Arg Val Phe Gln Lys Thr Lys Lys Gly Ile 
1               5                   10                  15      


Glu Arg Leu Thr Val Ile Gly Glu His Ala Trp Asp Phe Gly Ser Ala 
            20                  25                  30          


Gly Gly Phe Leu Ser Ser Ile Gly Lys Ala Val His Thr Val Leu Gly 
        35                  40                  45              


Gly Ala Phe Asn Ser Ile Phe Gly 
    50                  55      


<210>  186
<211>  56
<212>  PRT
<213>  Dengue virus stem anchor sequence 1

<400>  186

Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala 
1               5                   10                  15      


Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile 
            20                  25                  30          


Gly Gly Val Phe Thr Ser Val Gly Lys Leu Val His Gln Ile Phe Gly 
        35                  40                  45              


Thr Ala Tyr Gly Val Leu Phe Ser 
    50                  55      


<210>  187
<211>  56
<212>  PRT
<213>  Dengue virus stem anchor sequence 2

<400>  187

Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala 
1               5                   10                  15      


Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu 
            20                  25                  30          


Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly 
        35                  40                  45              


Ala Ile Tyr Gly Ala Ala Phe Ser 
    50                  55      


<210>  188
<211>  56
<212>  PRT
<213>  Japanese encephalitis stem anchor sequence

<400>  188

Ala Gly Ser Thr Leu Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala 
1               5                   10                  15      


Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile 
            20                  25                  30          


Gly Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly 
        35                  40                  45              


Gly Ala Phe Arg Thr Leu Phe Gly 
    50                  55      


<210>  189
<211>  56
<212>  PRT
<213>  St. Louis encephalitis virus stem anchor sequence

<400>  189

Glu Gly Ser Ser Ile Gly Lys Ala Leu Ala Thr Thr Trp Lys Gly Ala 
1               5                   10                  15      


Gln Arg Leu Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile 
            20                  25                  30          


Gly Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly 
        35                  40                  45              


Gly Ala Phe Arg Thr Leu Phe Gly 
    50                  55      


<210>  190
<211>  56
<212>  PRT
<213>  West Nile virus stem anchor sequence

<400>  190

Ser Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala 
1               5                   10                  15      


Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val 
            20                  25                  30          


Gly Gly Val Phe Thr Ser Val Gly Lys Ala Val His Gln Val Phe Gly 
        35                  40                  45              


Gly Ala Phe Arg Ser Leu Phe Gly 
    50                  55      


<210>  191
<211>  56
<212>  PRT
<213>  Yellow fever virus encephalitis sequence

<400>  191

Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln Thr Met Lys Gly Ala 
1               5                   10                  15      


Glu Arg Leu Ala Val Met Gly Asp Ala Ala Trp Asp Phe Ser Ser Ala 
            20                  25                  30          


Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile His Thr Val Phe Gly 
        35                  40                  45              


Ser Ala Phe Gln Gly Leu Phe Gly 
    50                  55      


<210>  192
<211>  19075
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pTM 2ATU MV Schw short

<400>  192
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac ggcgcgcagc     3540

gcttagacgt ctcgcgatcg atactagtac aacctaaatc cattataaaa aacttaggag     3600

caaagtgatt gcctcccaag gtccacaatg acagagacct acgacttcga caagtcggca     3660

tgggacatca aagggtcgat cgctccgata caacccacca cctacagtga tggcaggctg     3720

gtgccccagg tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg     3780

tacatgtttc tgctgggggt tgttgaggac agcgattccc tagggcctcc aatcgggcga     3840

gcatttgggt tcctgccctt aggtgttggc agatccacag caaagcccga aaaactcctc     3900

aaagaggcca ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg     3960

gtgttctaca acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca     4020

gggagtgtct tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc     4080

ccgcagaggt tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac     4140

accgttccta gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg     4200

gtgaccctta ggattgacaa ggcgataggc cctgggaaga tcatcgacaa tacagagcaa     4260

cttcctgagg caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc     4320

tactctgccg attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt     4380

gggatagggg gcaccagtct tcacattaga agcacaggca aaatgagcaa gactctccat     4440

gcacaactcg ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt     4500

aatcgattac tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca     4560

tcagttcctc aagaattccg catttacgac gacgtgatca taaatgatga ccaaggacta     4620

ttcaaagttc tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga     4680

cagccagaag gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg     4740

ccagccagca gccgacggca agcgcgaaca ccaggcggcc ccagcacaga acagccctga     4800

cacaaggcca ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa     4860

cccccaaggc tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc cgggaaagaa     4920

acccccagca attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa     4980

ccgcacaagc gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc     5040

tccccggcaa actaaacaaa acttagggcc aaggaacata cacacccaac agaacccaga     5100

ccccggccca cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc     5160

ccgccggctc ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcaccc     5220

aaccatcgac aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag     5280

ccagcaccgc gaggaagccc acccacccca cacacgacca cggcaaccaa accagaaccc     5340

agaccaccct gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca     5400

caacccgcgc accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa     5460

gagcgatccc cgaaggaccc ccgaaccgca aaggacatca gtatcccaca gcctctccaa     5520

gtcccccggt ctcctcctct tctcgaaggg accaaaagat caatccacca cacccgacga     5580

cactcaactc cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat     5640

gtccatcatg ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct     5700

ccaaacaccc accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat     5760

aggaagtgca agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt     5820

aatgcccaat ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag     5880

actactgaga acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat     5940

aagaccggtt cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct     6000

ggcaggtgcg gccctaggcg ttgccacagc tgctcagata acagccggca ttgcacttca     6060

ccagtccatg ctgaactctc aagccatcga caatctgaga gcgagcctgg aaactactaa     6120

tcaggcaatt gagacaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt     6180

ccaagactac atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat     6240

cggccagaag ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg     6300

ccccagttta cgggacccca tatctgcgga gatatctatc caggctttga gctatgcgct     6360

tggaggagac atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg     6420

catcttagag agcggaggaa taaaggcccg gataactcac gtcgacacag agtcctactt     6480

cattgtcctc agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg     6540

gctagagggg gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta     6600

tgttgcaacc caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc     6660

agaggggact gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg     6720

cctccggggg tacaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg     6780

gttcatttta tcacaaggga acctaatagc caattgtgca tcaatccttt gcaagtgtta     6840

cacaacagga acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga     6900

tcactgcccg gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc     6960

agacgctgtg tacttgcaca gaattgacct cggtcctccc atatcattgg agaggttgga     7020

cgtagggaca aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga     7080

gtcatcggac cagatattga ggagtatgaa aggtttatcg agcactagca tagtctacat     7140

cctgattgca gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag     7200

ggggcgttgt aacaaaaagg gagaacaagt tggtatgtca agaccaggcc taaagcctga     7260

tcttacggga acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac     7320

acaaatgtcc cacaagtctc ctcttcgtca tcaagcaacc accgcaccca gcatcaagcc     7380

cacctgaaat tatctccggc ttccctctgg ccgaacaata tcggtagtta atcaaaactt     7440

agggtgcaag atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag     7500

ataaccccca tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata     7560

gaccttatgt tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag     7620

ccattgcagg cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc     7680

tcagcaccaa tctagatgta actaactcaa tcgagcatca ggtcaaggac gtgctgacac     7740

cactcttcaa aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc     7800

tagtgaaatt aatctctgac aagattaaat tccttaatcc ggatagggag tacgacttca     7860

gagatctcac ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact     7920

gtgcagatgt ggctgctgaa gagctcatga atgcattggt gaactcaact ctactggaga     7980

ccagaacaac caatcagttc ctagctgtct caaagggaaa ctgctcaggg cccactacaa     8040

tcagaggtca attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt     8100

acaatgtgtc atctatagtc actatgacat cccagggaat gtatggggga acttacctag     8160

tggaaaagcc taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag     8220

tgtttgaagt aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa     8280

actatcttga gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc     8340

tcaaactcgc agccctttgt cacggggaag attctatcac aattccctat cagggatcag     8400

ggaaaggtgt cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc     8460

aatcctgggt ccccttatca acggatgatc cagtgataga caggctttac ctctcatctc     8520

acagaggtgt tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg     8580

acaagttgcg aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct     8640

gcgagaatcc cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt     8700

ctgttgatct gagtctgaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat     8760

tgatcacaca cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc     8820

tgactatccc gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac     8880

cgagattcaa ggttagtccc tacctcttca ctgtcccaat taaggaagca ggcgaagact     8940

gccatgcccc aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc     9000

tggtgattct acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg     9060

ttgaacatgc tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc     9120

cttttaggtt gcctataaag ggggtcccca tcgaattaca agtggaatgc ttcacatggg     9180

accaaaaact ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata     9240

tcactcactc tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa     9300

ccaatcgcag atagggctgc tagtgaacca atcacatgat gtcacccaga catcaggcat     9360

acccactagt gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc     9420

gttatggact cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg     9480

atagttacca ataagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc     9540

ctggaggacc ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac     9600

caaatgatta taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat     9660

ccggcccact ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac     9720

aaagagtcaa cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa     9780

gtcagtgata aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc     9840

gaattgaggg aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc     9900

cagtggtttg agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt     9960

aaatcacaaa cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt    10020

tcagttgagt tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat    10080

gtatattacc tgacatttga actggttttg atgtattgtg atgtcataga ggggaggtta    10140

atgacagaga ccgctatgac tattgatgct aggtatacag agcttctagg aagagtcaga    10200

tacatgtgga aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt    10260

gtagccatgc tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa    10320

ctcagaggtg ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac    10380

gggttttctg atgaaggtac ttatcatgag ttaactgaag ctctagatta cattttcata    10440

actgatgaca tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc    10500

agacttgaag cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc    10560

attgtgtatg agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc    10620

tatcgtgaca ggcacggagg cagttggcca ccgctgaccc tccccctgca tgctgcagac    10680

acaatccgga atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac    10740

tggaaatctt ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat    10800

ctgacaatgt acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt    10860

tacccgaaag agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta    10920

gatgttttcc ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt    10980

ggagcttacc tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc    11040

aaggaaacag gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt    11100

gctgaaaatc taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag    11160

gatgagcacg atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat    11220

ctcaaagaaa gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac    11280

acaagtacca ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg    11340

caggaccaag acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt    11400

atcacgactg atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt    11460

gcacagaggc taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg    11520

cttgagacct ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat    11580

atcccgttat ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata    11640

gaagggtatt gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct    11700

tatgagagcg gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta    11760

acaaaaaggg tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta    11820

actagagatt actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag    11880

gcaaatgaga caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat    11940

gggctacttg tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact    12000

atagttgatg aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc    12060

gagagaggtt atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa    12120

attctgatct ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc    12180

ctcctcacaa acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg    12240

atgaattatc tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca    12300

tcaattgctg atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat    12360

caagtaatga cacaacaacc gggggactct tcattcctag actgggctag cgacccttac    12420

tcagcaaatc ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg    12480

tttgtcctga tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa    12540

gaagaggacg agggactggc ggcattcctc atggacaggc atattatagt acctagggca    12600

gctcatgaaa tcctggatca tagtgtcaca ggggcaagag agtctattgc aggcatgctg    12660

gataccacaa aaggcttgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg    12720

ataaccagat tgtccaatta tgactatgaa caattcagag cagggatggt gctattgaca    12780

ggaagaaaga gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct    12840

ctaagaagcc atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc    12900

cctgatgtac tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc    12960

tgcgagtgtg gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat    13020

gatattgaca aggaaacatc atccttgaga gtcccatata ttggttctac cactgatgag    13080

agaacagaca tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt    13140

agaatagcaa cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc    13200

tggttgttgg ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc    13260

atctcaactt cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac    13320

tcaggtacat cccttgtccg agtggcgagg tataccacaa tctccaacga caatctctca    13380

tttgtcatat cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta    13440

gggttgggtg ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg    13500

gtattacatc ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg    13560

atacccagct cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat    13620

gataatgcac ctttaattga cagagatgca acaaggctat acacccagag ccataggagg    13680

caccttgtgg aatttgttac atggtccaca ccccaactat atcacatttt agctaagtcc    13740

acagcactat ctatgattga cctggtaaca aaatttgaga aggaccatat gaatgaaatt    13800

tcagctctca taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag    13860

ccaagattat tcactatcta cttgggccag tgtgcggcca tcaattgggc atttgatgta    13920

cattatcata gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct    13980

agaatgagca aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac    14040

aagaaattct ggcattgtgg tattatagag cctatccatg gtccttcact tgatgctcaa    14100

aacttgcaca caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg    14160

ttgttgaatg aagagttaga agagttcaca tttctcttgt gtgaaagcga cgaggatgta    14220

gtaccggaca gattcgacaa catccaggca aaacacttat gtgttctggc agatttgtac    14280

tgtcaaccag ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt    14340

ctaaccgacc atatcaaggc agaggctatg ttatctccag caggatcttc gtggaacata    14400

aatccaatta ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc    14460

aaacagataa gattgagagt tgatccagga ttcattttcg acgccctcgc tgaggtaaat    14520

gtcagtcagc caaagatcgg cagcaacaac atctcaaata tgagcatcaa ggctttcaga    14580

cccccacacg atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt    14640

cccatttcag ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg    14700

aactcatctg cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag    14760

ccaggggagg acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataaa    14820

gagatactta aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct    14880

ggtcaaaggg aattagcacc ctatccctcc gaagttggcc ttgtcgaaca cagaatggga    14940

gtaggtaata ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt    15000

gtagattgct tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat    15060

tcagatatag agaccttgcc tgacaaagat actatagaga agctagagga attggcagcc    15120

atcttatcga tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg    15180

cctttcagcg gggattttgt tcagggattt ataagttatg tagggtctca ttatagagaa    15240

gtgaaccttg tataccctag atacagcaac ttcatctcta ctgaatctta tttggttatg    15300

acagatctca aggctaaccg gctaatgaat cctgaaaaga ttaagcagca gataattgaa    15360

tcatctgtga ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc    15420

tgcatacaag caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa    15480

aaacttacac ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag    15540

ctgtgcaaag aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct    15600

atactcatcc tctacaggga gttggcaaga ttcaaagaca accaaagaag tcaacaaggg    15660

atgttccacg cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc    15720

acccgcaaat tctgggggca cattcttctt tactccggga acaaaaagtt gataaataag    15780

tttatccaga atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt    15840

aagaatctat ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg    15900

gtttttaagg taacagtcaa ggagaccaaa gaatggtata agttagtcgg atacagtgcc    15960

ctgattaagg actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca    16020

ttatttgcaa tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc    16080

tggtggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat tccgagggga    16140

ccgtcccctc ggtaatggcg aatgggacgc ggccgatccg gctgctaaca aagcccgaaa    16200

ggaagctgag ttggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc    16260

taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatccggat gcggccgcgg    16320

gccctatggt acccagcttt tgttcccttt agtgagggtt aattccgagc ttggcgtaat    16380

catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatag    16440

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgaggtaa ctcacattaa    16500

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat    16560

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc    16620

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg    16680

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag    16740

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcg    16800

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag    16860

gactataaag ataccaggcg ttcccccctg gaagctccct cgtgcgctct cctgttccga    16920

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc    16980

aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg    17040

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt    17100

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca    17160

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca    17220

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag    17280

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca    17340

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg    17400

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa    17460

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta    17520

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag    17580

cgatctgtct atttcgttca tccatagttg cctgactgcc cgtcgtgtag ataactacga    17640

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac    17700

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc    17760

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta    17820

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac    17880

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat    17940

gatcccccat gttgtgaaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa    18000

gtaagttggc cgcagtgtta tcactcatgc ttatggcagc actgcataat tctcttactg    18060

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag    18120

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc    18180

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct    18240

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat    18300

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg    18360

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc    18420

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta    18480

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa    18540

ttgtaaacgt taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt    18600

ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag    18660

ggttgagtgt tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg    18720

tcaaagggcg aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat    18780

caagtttttt ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc    18840

gatttagagc ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga    18900

aaggagcggg cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac    18960

ccgccgcgct taatgcgccg ctacagggcg cgtcccattc gccattcagg ctgcgcaact    19020

gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagccaccg cggtg         19075


