                         SEQUENCE LISTING

<110>  University College Dublin, National University of Ireland, 
       Dublin
 
<120>  COMPOSITION AND USES THEREOF

<130>  P32871WO/SNB

<150>  GB1522814.1
<151>  2015-12-23

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sp 16 Mature Protease Amino Acid Sequence

<400>  1

Tyr Thr Pro Asn Asp Pro Tyr Phe Ser Ser Arg Gln Tyr Gly Pro Gln 
1               5                   10                  15      


Lys Ile Gln Ala Pro Gln Ala Trp Asp Ile Ala Glu Gly Ser Gly Val 
            20                  25                  30          


Lys Ile Ala Ile Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu 
        35                  40                  45              


Ala Gly Lys Val Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr 
    50                  55                  60                  


Pro Gln Asp Gly Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala 
65                  70                  75                  80  


Ala Val Thr Asn Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala 
                85                  90                  95      


Ser Ile Leu Ala Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp 
            100                 105                 110         


Thr Ala Val Ala Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Lys 
        115                 120                 125             


Val Ile Ser Leu Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln 
    130                 135                 140                 


Gln Ala Val Asp Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala 
145                 150                 155                 160 


Ala Gly Asn Ala Gly Asn Thr Ala Pro Asn Tyr Pro Ala Tyr Tyr Ser 
                165                 170                 175     


Asn Ala Ile Ala Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser 
            180                 185                 190         


Phe Ser Thr Tyr Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser 
        195                 200                 205             


Ile Tyr Ser Thr Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr 
    210                 215                 220                 


Ser Met Ala Thr Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser 
225                 230                 235                 240 


Gln Gly Arg Ser Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala 
                245                 250                 255     


Asp Lys Ile Ser Gly Thr Gly Thr Tyr Trp Ala Lys Gly Arg Val Asn 
            260                 265                 270         


Ala Tyr Lys Ala Val Gln Tyr 
        275                 


<210>  2
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sp 16 Protease Amino Acid Sequence

<400>  2

Met Lys Lys Arg Val Ser Leu Ile Ala Ser Phe Val Leu Met Ala Ser 
1               5                   10                  15      


Ala Ala Leu Pro Ser Ala Ile Phe Ala Glu Glu Val Asp Ser Gln Ala 
            20                  25                  30          


Gly Lys Leu Tyr Ala Pro Gly Gln Val Val Val Lys Tyr Lys Asp Asn 
        35                  40                  45              


Ala Ser Ala Ser Ala Val Lys Ser Ala Arg Ala Lys Ala Asn Gly Thr 
    50                  55                  60                  


Val Met Glu Lys Asn Asn Lys Leu Gly Phe Glu Val Val Lys Val Lys 
65                  70                  75                  80  


Gly Ser Val Glu Ala Thr Ile Glu Lys Leu Lys Lys Asp Pro Asn Val 
                85                  90                  95      


Glu Tyr Ala Glu Pro Asn Tyr Tyr Leu His Ala Thr Tyr Thr Pro Asn 
            100                 105                 110         


Asp Pro Tyr Phe Ser Ser Arg Gln Tyr Gly Pro Gln Lys Ile Gln Ala 
        115                 120                 125             


Pro Gln Ala Trp Asp Ile Ala Glu Gly Ser Gly Val Lys Ile Ala Ile 
    130                 135                 140                 


Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu Ala Gly Lys Val 
145                 150                 155                 160 


Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr Pro Gln Asp Gly 
                165                 170                 175     


Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala Ala Val Thr Asn 
            180                 185                 190         


Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala Ser Ile Leu Ala 
        195                 200                 205             


Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp Thr Ala Val Ala 
    210                 215                 220                 


Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Lys Val Ile Ser Leu 
225                 230                 235                 240 


Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln Gln Ala Val Asp 
                245                 250                 255     


Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala Ala Gly Asn Ala 
            260                 265                 270         


Gly Asn Thr Ala Pro Asn Tyr Pro Ala Tyr Tyr Ser Asn Ala Ile Ala 
        275                 280                 285             


Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser Phe Ser Thr Tyr 
    290                 295                 300                 


Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser Ile Tyr Ser Thr 
305                 310                 315                 320 


Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr Ser Met Ala Thr 
                325                 330                 335     


Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser Gln Gly Arg Ser 
            340                 345                 350         


Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala Asp Lys Ile Ser 
        355                 360                 365             


Gly Thr Gly Thr Tyr Trp Ala Lys Gly Arg Val Asn Ala Tyr Lys Ala 
    370                 375                 380                 


Val Gln Tyr 
385         


<210>  3
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp 16 DNA Sequence

<400>  3
atgaagaaac gcgtttccct catcgcttcc ttcgttttga tggcaagcgc cgccctgcct       60

tccgccattt tcgctgagga agtagatagc caagcgggta aactctatgc tccagggcaa      120

gtcgtggtga aatacaaaga caatgcttcg gccagcgccg tcaaatctgc ccgcgccaaa      180

gccaacggta cagtcatgga gaaaaacaac aagctcggct ttgaagtggt caaagtgaaa      240

ggctctgtgg aagcgaccat cgaaaagctg aaaaaagacc ccaacgtgga atatgctgaa      300

cccaactact atctccacgc tacctacaca cctaacgatc cttacttcag ctcccgccaa      360

tacggcccac aaaaaatcca agcgccgcag gcatgggaca tcgctgaagg ctccggcgtg      420

aaaatcgcca tcgtcgacac cggggtgcaa tccaaccatc ccgacttggc cggtaaagta      480

gtgggcggtt gggacttcgt tgacaacgac tccactccgc aagatggcaa cggccacggt      540

acacactgcg ctggtatcgc cgcagcagtg accaacaaca gcaccgggat cgctggtact      600

gccccgaaag cgtcaatcct cgctgtgcgc gtgctggaca acagcggtag cggcacctgg      660

actgctgtcg ccaacggtat cacctatgct gcagaccaag gcgctaaagt catcagcttg      720

agcttgggcg gcaccgttgg taactccggt ctgcaacaag ctgtcgacta cgcttggaac      780

aaaggttccg ttgtcgtggc cgcggctggt aacgccggca acaccgctcc taactatccc      840

gcttactatt ccaacgccat cgcggtagct tctactgacc aaaatgacaa caaatcctcc      900

ttctccactt acggttcctg ggtagatgta gctgctcctg gttccagcat ctattccacc      960

tacccgacca gcacctacgc ttccttgagc ggtacctcca tggctactcc tcacgtagct     1020

ggtgtggctg gactcttggc ttcccaaggc cgtagcgctt ccaatatccg cgccgccatt     1080

gaaaacaccg ccgacaaaat cagcggcact ggcacctact gggccaaagg acgcgtcaac     1140

gcttacaaag ctgttcagta ctaa                                            1164


<210>  4
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sp 10 Mature Protease Amino Acid Sequence

<400>  4

Tyr Thr Pro Asn Asp Pro Tyr Phe Ser Thr Arg Gln Tyr Gly Pro Gln 
1               5                   10                  15      


Lys Ile Gln Ala Pro Gln Ala Trp Asp Ile Thr Glu Gly Ser Gly Ala 
            20                  25                  30          


Lys Ile Ala Ile Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu 
        35                  40                  45              


Ala Gly Lys Val Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr 
    50                  55                  60                  


Pro Gln Asp Gly Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala 
65                  70                  75                  80  


Ala Val Thr Asn Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala 
                85                  90                  95      


Ser Ile Leu Ala Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp 
            100                 105                 110         


Thr Ala Val Ala Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Asp 
        115                 120                 125             


Val Ile Ser Leu Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln 
    130                 135                 140                 


Gln Ala Val Asn Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala 
145                 150                 155                 160 


Ala Gly Asn Ala Gly Asn Thr Ala Pro His Tyr Pro Ala Tyr Tyr Ser 
                165                 170                 175     


Asn Ala Ile Ala Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser 
            180                 185                 190         


Phe Ser Thr Tyr Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser 
        195                 200                 205             


Ile Tyr Ala Thr Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr 
    210                 215                 220                 


Ser Met Ala Thr Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser 
225                 230                 235                 240 


Gln Gly Arg Ser Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala 
                245                 250                 255     


Asp Lys Ile Ser Gly Thr Gly Ser Tyr Trp Ala Lys Gly Arg Val Asn 
            260                 265                 270         


Ala Tyr Lys Ala Val Gln Tyr 
        275                 


<210>  5
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sp 10 Protease Amino Acid Sequence

<400>  5

Met Lys Lys Arg Val Ser Leu Ile Ala Ser Phe Val Leu Met Ala Ser 
1               5                   10                  15      


Ala Ala Leu Pro Ser Ala Ile Phe Ala Glu Glu Val Asp Ser Gln Ala 
            20                  25                  30          


Gly Lys Leu Tyr Ala Pro Gly Gln Val Val Val Lys Tyr Lys Asp Asn 
        35                  40                  45              


Ala Ser Ala Ser Ala Val Lys Ser Ala Arg Ala Lys Ala Asn Gly Thr 
    50                  55                  60                  


Val Met Glu Lys Asn Asn Lys Leu Gly Phe Glu Val Val Lys Val Lys 
65                  70                  75                  80  


Gly Ser Val Glu Ala Thr Ile Glu Lys Leu Lys Lys Asp Pro Asn Val 
                85                  90                  95      


Glu Tyr Ala Glu Pro Asn Tyr Tyr Leu His Ala Ser Tyr Thr Pro Asn 
            100                 105                 110         


Asp Pro Tyr Phe Ser Thr Arg Gln Tyr Gly Pro Gln Lys Ile Gln Ala 
        115                 120                 125             


Pro Gln Ala Trp Asp Ile Thr Glu Gly Ser Gly Ala Lys Ile Ala Ile 
    130                 135                 140                 


Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu Ala Gly Lys Val 
145                 150                 155                 160 


Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr Pro Gln Asp Gly 
                165                 170                 175     


Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala Ala Val Thr Asn 
            180                 185                 190         


Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala Ser Ile Leu Ala 
        195                 200                 205             


Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp Thr Ala Val Ala 
    210                 215                 220                 


Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Asp Val Ile Ser Leu 
225                 230                 235                 240 


Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln Gln Ala Val Asn 
                245                 250                 255     


Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala Ala Gly Asn Ala 
            260                 265                 270         


Gly Asn Thr Ala Pro His Tyr Pro Ala Tyr Tyr Ser Asn Ala Ile Ala 
        275                 280                 285             


Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser Phe Ser Thr Tyr 
    290                 295                 300                 


Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser Ile Tyr Ala Thr 
305                 310                 315                 320 


Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr Ser Met Ala Thr 
                325                 330                 335     


Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser Gln Gly Arg Ser 
            340                 345                 350         


Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala Asp Lys Ile Ser 
        355                 360                 365             


Gly Thr Gly Ser Tyr Trp Ala Lys Gly Arg Val Asn Ala Tyr Lys Ala 
    370                 375                 380                 


Val Gln Tyr 
385         


<210>  6
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp 10 DNA Sequence

<400>  6
atgaagaaac gcgtttccct catcgcttcc ttcgttttga tggccagcgc cgccctgcct       60

tccgccattt tcgcagagga agtagatagc caagcgggta aactctacgc ccccgggcaa      120

gttgtggtga aatacaaaga caatgcttcg gccagcgctg tcaaatctgc ccgcgccaaa      180

gccaacggta cagtcatgga gaaaaacaac aagctcggct tcgaagtggt caaagtgaaa      240

ggctctgtgg aagcgaccat cgaaaagctg aaaaaagacc ccaacgtgga atatgctgag      300

cccaactact atctccacgc ttcctacacg cctaacgatc cttacttcag cacccgccaa      360

tacggcccac aaaaaatcca agcgccacaa gcatgggaca tcactgaagg ctccggcgcg      420

aagatcgcca tcgtcgacac cggggtacaa tccaaccatc ccgacttggc cggtaaagta      480

gtgggcggtt gggacttcgt tgacaacgac tccacgccac aagatggcaa cggccacggt      540

acccactgcg ctggtatcgc cgcagcagtg accaacaaca gcaccgggat cgctggtact      600

gctccaaaag cgtcgatcct cgctgtgcgc gtgctggaca acagtggtag cggcacctgg      660

actgctgtcg ccaacggtat cacctatgcc gcagaccaag gtgctgacgt catcagcttg      720

agcttgggcg gcaccgtcgg taactccggt ctgcaacaag ctgtcaacta cgcttggaac      780

aaaggttctg ttgtcgtggc cgcagctggt aacgccggca acaccgctcc tcactatcct      840

gcatactatt ccaacgccat cgcggtagct tctactgacc aaaatgacaa caaatcctcc      900

ttctccactt acggttcctg ggtagatgta gccgctcctg gttccagcat ctatgctact      960

tatccgacca gcacctacgc ttccttgagc ggtacctcca tggctactcc ccatgtggct     1020

ggagtggctg gactcctggc ttcccaaggc cgtagtgctt ccaacatccg cgccgctatt     1080

gaaaacaccg ccgacaaaat cagcggcacc ggctcctact gggccaaagg gcgcgtcaac     1140

gcttacaaag ctgttcagta ctaa                                            1164


<210>  7
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Thermitase FL-SapI F Primer

<400>  7
ctcgatgctc ttccgcaatg aagaaacgcg tttccct                                37


<210>  8
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Thermitase FL-Xhol R Primer

<400>  8
ctcgagttag tactgaacag ctttgtaagc g                                      31


<210>  9
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Thermitase  Delta N-sapI Primer

<400>  9
ctcgatgctc ttccgcagag gaagtagata gccaagcgg                              39


<210>  10
<211>  75
<212>  DNA
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  10
atgaagaaac gcgtttccct catcgcttcc ttcgttttga tggcaagcgc cgccctgcct       60

tccgccattt tcgct                                                        75


<210>  11
<211>  249
<212>  DNA
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  11
gaggaagtag atagccaagc gggtaaactc tatgctccag ggcaagtcgt ggtgaaatac       60

aaagacaatg cttcggccag cgccgtcaaa tctgcccgcg ccaaagccaa cggtacagtc      120

atggagaaaa acaacaagct cggctttgaa gtggtcaaag tgaaaggctc tgtggaagcg      180

accatcgaaa agctgaaaaa agaccccaac gtggaatatg ctgaacccaa ctactatctc      240

cacgctacc                                                              249


<210>  12
<211>  840
<212>  DNA
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  12
tacacaccta acgatcctta cttcagctcc cgccaatacg gcccacaaaa aatccaagcg       60

ccgcaggcat gggacatcgc tgaaggctcc ggcgtgaaaa tcgccatcgt cgacaccggg      120

gtgcaatcca accatcccga cttggccggt aaagtagtgg gcggttggga cttcgttgac      180

aacgactcca ctccgcaaga tggcaacggc cacggtacac actgcgctgg tatcgccgca      240

gcagtgacca acaacagcac cgggatcgct ggtactgccc cgaaagcgtc aatcctcgct      300

gtgcgcgtgc tggacaacag cggtagcggc acctggactg ctgtcgccaa cggtatcacc      360

tatgctgcag accaaggcgc taaagtcatc agcttgagct tgggcggcac cgttggtaac      420

tccggtctgc aacaagctgt cgactacgct tggaacaaag gttccgttgt cgtggccgcg      480

gctggtaacg ccggcaacac cgctcctaac tatcccgctt actattccaa cgccatcgcg      540

gtagcttcta ctgaccaaaa tgacaacaaa tcctccttct ccacttacgg ttcctgggta      600

gatgtagctg ctcctggttc cagcatctat tccacctacc cgaccagcac ctacgcttcc      660

ttgagcggta cctccatggc tactcctcac gtagctggtg tggctggact cttggcttcc      720

caaggccgta gcgcttccaa tatccgcgcc gccattgaaa acaccgccga caaaatcagc      780

ggcactggca cctactgggc caaaggacgc gtcaacgctt acaaagctgt tcagtactaa      840


<210>  13
<211>  25
<212>  PRT
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  13

Met Lys Lys Arg Val Ser Leu Ile Ala Ser Phe Val Leu Met Ala Ser 
1               5                   10                  15      


Ala Ala Leu Pro Ser Ala Ile Phe Ala 
            20                  25  


<210>  14
<211>  83
<212>  PRT
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  14

Glu Glu Val Asp Ser Gln Ala Gly Lys Leu Tyr Ala Pro Gly Gln Val 
1               5                   10                  15      


Val Val Lys Tyr Lys Asp Asn Ala Ser Ala Ser Ala Val Lys Ser Ala 
            20                  25                  30          


Arg Ala Lys Ala Asn Gly Thr Val Met Glu Lys Asn Asn Lys Leu Gly 
        35                  40                  45              


Phe Glu Val Val Lys Val Lys Gly Ser Val Glu Ala Thr Ile Glu Lys 
    50                  55                  60                  


Leu Lys Lys Asp Pro Asn Val Glu Tyr Ala Glu Pro Asn Tyr Tyr Leu 
65                  70                  75                  80  


His Ala Thr 
            


<210>  15
<211>  279
<212>  PRT
<213>  Thermoactinomycete sp. 16 (Thermophilic streptomycetes)

<400>  15

Tyr Thr Pro Asn Asp Pro Tyr Phe Ser Ser Arg Gln Tyr Gly Pro Gln 
1               5                   10                  15      


Lys Ile Gln Ala Pro Gln Ala Trp Asp Ile Ala Glu Gly Ser Gly Val 
            20                  25                  30          


Lys Ile Ala Ile Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu 
        35                  40                  45              


Ala Gly Lys Val Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr 
    50                  55                  60                  


Pro Gln Asp Gly Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala 
65                  70                  75                  80  


Ala Val Thr Asn Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala 
                85                  90                  95      


Ser Ile Leu Ala Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp 
            100                 105                 110         


Thr Ala Val Ala Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Lys 
        115                 120                 125             


Val Ile Ser Leu Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln 
    130                 135                 140                 


Gln Ala Val Asp Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala 
145                 150                 155                 160 


Ala Gly Asn Ala Gly Asn Thr Ala Pro Asn Tyr Pro Ala Tyr Tyr Ser 
                165                 170                 175     


Asn Ala Ile Ala Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser 
            180                 185                 190         


Phe Ser Thr Tyr Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser 
        195                 200                 205             


Ile Tyr Ser Thr Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr 
    210                 215                 220                 


Ser Met Ala Thr Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser 
225                 230                 235                 240 


Gln Gly Arg Ser Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala 
                245                 250                 255     


Asp Lys Ile Ser Gly Thr Gly Thr Tyr Trp Ala Lys Gly Arg Val Asn 
            260                 265                 270         


Ala Tyr Lys Ala Val Gln Tyr 
        275                 


<210>  16
<211>  75
<212>  DNA
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  16
atgaagaaac gcgtttccct catcgcttcc ttcgttttga tggccagcgc cgccctgcct       60

tccgccattt tcgca                                                        75


<210>  17
<211>  249
<212>  DNA
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  17
gaggaagtag atagccaagc gggtaaactc tacgcccccg ggcaagttgt ggtgaaatac       60

aaagacaatg cttcggccag cgctgtcaaa tctgcccgcg ccaaagccaa cggtacagtc      120

atggagaaaa acaacaagct cggcttcgaa gtggtcaaag tgaaaggctc tgtggaagcg      180

accatcgaaa agctgaaaaa agaccccaac gtggaatatg ctgagcccaa ctactatctc      240

cacgcttcc                                                              249


<210>  18
<211>  840
<212>  DNA
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  18
tacacgccta acgatcctta cttcagcacc cgccaatacg gcccacaaaa aatccaagcg       60

ccacaagcat gggacatcac tgaaggctcc ggcgcgaaga tcgccatcgt cgacaccggg      120

gtacaatcca accatcccga cttggccggt aaagtagtgg gcggttggga cttcgttgac      180

aacgactcca cgccacaaga tggcaacggc cacggtaccc actgcgctgg tatcgccgca      240

gcagtgacca acaacagcac cgggatcgct ggtactgctc caaaagcgtc gatcctcgct      300

gtgcgcgtgc tggacaacag tggtagcggc acctggactg ctgtcgccaa cggtatcacc      360

tatgccgcag accaaggtgc tgacgtcatc agcttgagct tgggcggcac cgtcggtaac      420

tccggtctgc aacaagctgt caactacgct tggaacaaag gttctgttgt cgtggccgca      480

gctggtaacg ccggcaacac cgctcctcac tatcctgcat actattccaa cgccatcgcg      540

gtagcttcta ctgaccaaaa tgacaacaaa tcctccttct ccacttacgg ttcctgggta      600

gatgtagccg ctcctggttc cagcatctat gctacttatc cgaccagcac ctacgcttcc      660

ttgagcggta cctccatggc tactccccat gtggctggag tggctggact cctggcttcc      720

caaggccgta gtgcttccaa catccgcgcc gctattgaaa acaccgccga caaaatcagc      780

ggcaccggct cctactgggc caaagggcgc gtcaacgctt acaaagctgt tcagtactaa      840


<210>  19
<211>  25
<212>  PRT
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  19

Met Lys Lys Arg Val Ser Leu Ile Ala Ser Phe Val Leu Met Ala Ser 
1               5                   10                  15      


Ala Ala Leu Pro Ser Ala Ile Phe Ala 
            20                  25  


<210>  20
<211>  83
<212>  PRT
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  20

Glu Glu Val Asp Ser Gln Ala Gly Lys Leu Tyr Ala Pro Gly Gln Val 
1               5                   10                  15      


Val Val Lys Tyr Lys Asp Asn Ala Ser Ala Ser Ala Val Lys Ser Ala 
            20                  25                  30          


Arg Ala Lys Ala Asn Gly Thr Val Met Glu Lys Asn Asn Lys Leu Gly 
        35                  40                  45              


Phe Glu Val Val Lys Val Lys Gly Ser Val Glu Ala Thr Ile Glu Lys 
    50                  55                  60                  


Leu Lys Lys Asp Pro Asn Val Glu Tyr Ala Glu Pro Asn Tyr Tyr Leu 
65                  70                  75                  80  


His Ala Ser 
            


<210>  21
<211>  279
<212>  PRT
<213>  Thermoactinomycete sp. 10 (Thermophilic streptomycetes)

<400>  21

Tyr Thr Pro Asn Asp Pro Tyr Phe Ser Thr Arg Gln Tyr Gly Pro Gln 
1               5                   10                  15      


Lys Ile Gln Ala Pro Gln Ala Trp Asp Ile Thr Glu Gly Ser Gly Ala 
            20                  25                  30          


Lys Ile Ala Ile Val Asp Thr Gly Val Gln Ser Asn His Pro Asp Leu 
        35                  40                  45              


Ala Gly Lys Val Val Gly Gly Trp Asp Phe Val Asp Asn Asp Ser Thr 
    50                  55                  60                  


Pro Gln Asp Gly Asn Gly His Gly Thr His Cys Ala Gly Ile Ala Ala 
65                  70                  75                  80  


Ala Val Thr Asn Asn Ser Thr Gly Ile Ala Gly Thr Ala Pro Lys Ala 
                85                  90                  95      


Ser Ile Leu Ala Val Arg Val Leu Asp Asn Ser Gly Ser Gly Thr Trp 
            100                 105                 110         


Thr Ala Val Ala Asn Gly Ile Thr Tyr Ala Ala Asp Gln Gly Ala Asp 
        115                 120                 125             


Val Ile Ser Leu Ser Leu Gly Gly Thr Val Gly Asn Ser Gly Leu Gln 
    130                 135                 140                 


Gln Ala Val Asn Tyr Ala Trp Asn Lys Gly Ser Val Val Val Ala Ala 
145                 150                 155                 160 


Ala Gly Asn Ala Gly Asn Thr Ala Pro His Tyr Pro Ala Tyr Tyr Ser 
                165                 170                 175     


Asn Ala Ile Ala Val Ala Ser Thr Asp Gln Asn Asp Asn Lys Ser Ser 
            180                 185                 190         


Phe Ser Thr Tyr Gly Ser Trp Val Asp Val Ala Ala Pro Gly Ser Ser 
        195                 200                 205             


Ile Tyr Ala Thr Tyr Pro Thr Ser Thr Tyr Ala Ser Leu Ser Gly Thr 
    210                 215                 220                 


Ser Met Ala Thr Pro His Val Ala Gly Val Ala Gly Leu Leu Ala Ser 
225                 230                 235                 240 


Gln Gly Arg Ser Ala Ser Asn Ile Arg Ala Ala Ile Glu Asn Thr Ala 
                245                 250                 255     


Asp Lys Ile Ser Gly Thr Gly Ser Tyr Trp Ala Lys Gly Arg Val Asn 
            260                 265                 270         


Ala Tyr Lys Ala Val Gln Tyr 
        275                 


