                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  Method for producing RNA molecule compositions

<130>  C09919WO2 / RN

<140>  
<141>  

<150>  PCT/EP2015/081000
<151>  2015.12.22

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1915
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  1
gggagaaagc uuaccaugaa ggccaaccug cucgugcugc ugugcgcccu cgcggccgcc       60

gacgccgaca ccaucugcau cggcuaccac gccaacaaca gcaccgacac ggucgacacc      120

gugcuggaga agaacgugac cgucacccac uccgugaacc ugcucgagga cagccacaac      180

gggaagcugu gccggcugaa gggcaucgcg ccccuccagc uggggaagug caacaucgcc      240

ggcuggcugc ucgggaaccc ggagugcgac ccccugcugc ccgugcgcuc cuggagcuac      300

aucgucgaga cgcccaacuc cgagaacggc aucugcuacc cgggcgacuu caucgacuac      360

gaggagcucc gggagcagcu gagcuccgug agcuccuucg agcgcuucga gaucuucccc      420

aaggagagcu ccuggcccaa ccacaacacc aacgggguga ccgccgccug cagccacgag      480

ggcaagucca gcuucuaccg gaaccugcuc uggcugaccg agaaggaggg guccuacccc      540

aagcugaaga acagcuacgu caacaagaag ggcaaggagg ugcucgugcu gugggggauc      600

caccacccgc ccaacuccaa ggagcagcag aaccuguacc agaacgagaa cgcguacguc      660

agcgugguga cguccaacua caaccgccgg uucacccccg agaucgccga gcgccccaag      720

guccgggacc aggccggccg caugaacuac uacuggaccc uccugaagcc gggcgacacc      780

aucaucuucg aggccaacgg gaaccugauc gccccgaugu acgcguucgc ccucagccgg      840

ggcuucggga gcggcaucau cacguccaac gccagcaugc acgagugcaa caccaagugc      900

cagacccccc ugggcgccau caacuccagc cugcccuacc agaacaucca cccggugacc      960

aucggggagu gccccaagua cgugcgcucc gccaagcucc ggauggucac gggccugcgc     1020

aacaacccca gcauccaguc ccgggggcug uucggcgcga ucgccggguu caucgagggc     1080

ggcuggaccg ggaugaucga cggcugguac ggguaccacc accagaacga gcagggcagc     1140

ggguacgccg ccgaccagaa guccacccag aacgccauca acggcaucac caacaaggug     1200

aacacgguga ucgagaagau gaacauccag uucaccgcgg ucggcaagga guucaacaag     1260

cucgagaagc gcauggagaa ccugaacaag aagguggacg acggguuccu ggacaucugg     1320

accuacaacg ccgagcuccu ggugcugcuc gagaacgagc ggacccugga cuuccacgac     1380

agcaacguca agaaccugua cgagaaggug aagucccagc ucaagaacaa cgccaaggag     1440

aucggcaacg ggugcuucga guucuaccac aagugcgaca acgagugcau ggagagcguc     1500

cgcaacggca cguacgacua ccccaaguac uccgaggaga gcaagcugaa ccgggagaag     1560

guggacgggg ugaagcugga guccaugggc aucuaccaga uccucgccau cuacagcacc     1620

gucgccucca gccuggugcu gcuggugucc cucggcgcga ucagcuucug gaugugcagc     1680

aacggguccc ugcagugccg caucugcauc ugaccacuag uuauaagacu gacuagcccg     1740

augggccucc caacgggccc uccuccccuc cuugcaccga gauuaauaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa augcaucccc     1860

cccccccccc cccccccccc cccccccaaa ggcucuuuuc agagccacca gaauu          1915


<210>  2
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  2
gggagaaagc uuaccaugaa ggccauccug gugguccucc uguacaccuu cgccaccgcg       60

aacgccgaca cgcugugcau cggcuaccac gccaacaaca gcaccgacac cguggacacc      120

gugcucgaga agaacgucac ggugacccac uccgugaacc ugcuggagga caagcacaac      180

gggaagcucu gcaagcugcg gggcgucgcc ccgcugcacc ucgggaagug caacaucgcc      240

ggcuggaucc uggggaaccc ggagugcgag agccugucca ccgcgagcuc cuggagcuac      300

aucguggaga ccuccagcuc cgacaacggc acgugcuacc ccggcgacuu caucgacuac      360

gaggagcucc gcgagcagcu gagcuccgug agcuccuucg agcgguucga gaucuucccc      420

aagaccagcu ccuggcccaa ccacgacagc aacaaggggg ucaccgccgc cugcccgcac      480

gccggcgcga aguccuucua caagaaccug aucuggcucg ugaagaaggg gaacagcuac      540

cccaagcugu ccaagagcua caucaacgac aagggcaagg aggugcuggu ccucuggggg      600

auccaccacc ccagcaccuc cgccgaccag cagagccugu accagaacgc cgacgccuac      660

guguucgugg gcuccagccg cuacuccaag aaguucaagc ccgagaucgc cauccggccg      720

aagguccgcg accaggaggg ccggaugaac uacuacugga cgcuggugga gcccggggac      780

aagaucaccu ucgaggcgac cggcaaccuc gugguccccc gcuacgccuu cgccauggag      840

cggaacgccg ggagcggcau caucaucucc gacacccccg ugcacgacug caacacgacc      900

ugccagaccc cgaagggcgc caucaacacc agccugcccu uccagaacau ccaccccauc      960

acgaucggga agugccccaa guacgugaag uccaccaagc ugcgccucgc gaccggccug     1020

cggaacgucc cgagcaucca gucccgcggg cuguucggcg ccaucgccgg guucaucgag     1080

ggcggcugga ccgggauggu ggacggcugg uacggguacc accaccagaa cgagcagggc     1140

agcggguacg ccgccgaccu caaguccacg cagaacgcga ucgacgagau caccaacaag     1200

gugaacagcg ucaucgagaa gaugaacacc caguucaccg ccgugggcaa ggaguucaac     1260

caccuggaga agcggaucga gaaccugaac aagaaggucg acgacggcuu ccucgacauc     1320

uggacguaca acgccgagcu gcuggugcuc cuggagaacg agcgcacccu ggacuaccac     1380

gacuccaacg ugaagaaccu cuacgagaag guccggagcc agcugaagaa caacgccaag     1440

gagaucggga acggcugcuu cgaguucuac cacaagugcg acaacaccug cauggagucc     1500

gugaagaacg ggaccuacga cuaccccaag uacagcgagg aggccaagcu gaaccgcgag     1560

gagaucgacg gcgugaagcu cgaguccacg cggaucuacc agauccuggc gaucuacagc     1620

accgucgcca gcucccuggu gcucgugguc agccuggggg ccaucuccuu cuggaugugc     1680

agcaacggcu cccugcagug ccgcaucugc aucugaccac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  3
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  3
gggagaaagc uuaccaugaa ggccauccug gugguccucc uguacaccuu cgccaccgcg       60

aacgccgaca cgcugugcau cggcuaccac gccaacaaca gcaccgacac cguggacacc      120

gugcucgaga agaacgucac ggugacccac uccgugaacc ugcuggagga caagcacaac      180

gggaagcucu gcaagcugcg gggcgucgcc ccgcugcacc ucgggaagug caacaucgcc      240

ggcuggaucc uggggaaccc ggagugcgag agccugucca ccgcgagcuc cuggagcuac      300

aucguggaga cccccuccag cgacaacggc acgugcuacc ccggcgacuu caucgacuac      360

gaggagcucc gcgagcagcu guccagcgug uccagcuucg agcgguucga gaucuucccc      420

aagaccucca gcuggccgaa ccacgacucc gacaaggggg ucaccgccgc cugcccccac      480

gccggcgcga agagcuucua caagaaccug aucuggcucg ugaagaaggg gaacuccuac      540

cccaagcuga gcaaguccua caucaacgac aagggcaagg aggugcuggu ccucuggggg      600

auccaccacc ccagcaccag cgccgaccag cagucccugu accagaacgc cgacgccuac      660

guguucgugg gcagcucccg cuacagcaag acguucaagc cggagaucgc cauccggccc      720

aagguccgcg accgggaggg ccgcaugaac uacuacugga cccuggugga gcccggggac      780

aagaucaccu ucgaggcgac cggcaaccuc gugguccccc gguacgccuu cgccauggag      840

cgcaacgccg gguccggcau caucaucagc gacacgccgg ugcacgacug caacaccacc      900

ugccagaccc ccaagggcgc caucaacacg ucccugcccu uccagaacau ccaccccauc      960

accaucggga agugcccgaa guacgugaag agcaccaagc ugcggcucgc gaccggccug     1020

cgcaacaucc ccuccaucca gagccggggg cuguucggcg ccaucgccgg guucaucgag     1080

ggcggcugga cggggauggu cgacggcugg uacggguacc accaccagaa cgagcagggc     1140

agcggguacg ccgccgaccu caaguccacg cagaacgcga ucgacgagau caccaacaag     1200

gugaacagcg ucaucgagaa gaugaacacc caguucaccg ccgugggcaa ggaguucaac     1260

caccuggaga agcggaucga gaaccugaac aagaaggucg acgacggcuu ccucgacauc     1320

uggacguaca acgccgagcu gcuggugcuc cuggagaacg agcgcacccu ggacuaccac     1380

gacuccaacg ugaagaaccu cuacgagaag guccggagcc agcugaagaa caacgccaag     1440

gagaucggga acggcugcuu cgaguucuac cacaagugcg acaacaccug cauggagucc     1500

gugaagaacg ggaccuacga cuaccccaag uacagcgagg aggccaagcu gaaccgcgag     1560

gagaucgacg gcgugaagcu cgaguccacg cggaucuacc agauccuggc gaucuacagc     1620

accgucgcca gcucccuggu gcucgugguc agccuggggg ccaucuccuu cuggaugugc     1680

agcaacggcu cccugcagug ccgcaucugc aucugaccac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  4
<211>  1912
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  4
gggagaaagc uuaccaugga gaagaucgug cugcucuucg ccaucgucag ccuggugaag       60

uccgaccaga ucugcaucgg cuaccacgcc aacaacagca ccgagcaggu ggacaccauc      120

auggagaaga acgucacggu gacccacgcg caggacaucc uggagaagac ccacaacggg      180

aagcucugcg accuggacgg cgugaagccc cugauccucc gggacugcuc cgucgccggg      240

uggcugcugg gcaacccgau gugcgacgag uucaucaacg ugcccgagug gagcuacauc      300

guggagaagg ccaaccccgu caacgaccuc ugcuaccccg gggacuucaa cgacuacgag      360

gagcugaagc accugcucuc ccgcaucaac cacuucgaga agauccagau caucccgaag      420

agcuccugga gcucccacga ggccagccug ggcgugucca gcgccugccc cuaccagggc      480

aaguccagcu ucuuccggaa cguggucugg cugaucaaga agaacuccac cuaccccacg      540

aucaagcgca gcuacaacaa caccaaccag gaggaccucc uggugcugug ggggauccac      600

caccccaacg acgcggccga gcagaccaag cucuaccaga acccgaccac guacaucucc      660

gugggcacca gcacccugaa ccagcggcug gucccccgca ucgccacccg guccaaggug      720

aacgggcaga gcggccgcau ggaguucuuc uggacgaucc ucaagcccaa cgacgccauc      780

aacuucgaga gcaacgggaa cuucaucgcg cccgaguacg ccuacaagau cgugaagaag      840

ggcgacucca ccaucaugaa gagcgagcug gaguacggca acugcaacac caagugccag      900

accccgaugg gggccaucaa cuccagcaug cccuuccaca acauccaccc ccugacgauc      960

ggcgagugcc ccaaguacgu caaguccaac cggcucgugc uggccaccgg gcugcgcaac     1020

agcccgcagc gggagacccg cggccucuuc ggcgccaucg cgggguucau cgagggcggg     1080

uggcagggca ugguggacgg gugguacggc uaccaccacu ccaacgagca gggcagcggg     1140

uacgccgccg acaaggaguc cacccagaag gccaucgacg gcgucacgaa caaggugaac     1200

agcaucaucg acaagaugaa cacccaguuc gaggccgugg ggcgggaguu caacaaccug     1260

gagcgccgga ucgagaaccu gaacaagaag auggaggacg gcuuccucga cgucuggacc     1320

uacaacgcgg agcugcuggu gcucauggag aacgagcgca cccuggacuu ccacgacucc     1380

aacgucaaga accuguacga caaggugcgg cuccagcugc gcgacaacgc caaggagcug     1440

gggaacggcu gcuucgaguu cuaccacaag ugcgacaacg agugcaugga gagcgugcgg     1500

aacggcacgu acgacuaccc ccaguacucc gaggaggccc gccucaagcg ggaggagauc     1560

agcgggguca agcuggaguc caucggcauc uaccagaucc ugagcaucua cuccaccgug     1620

gccagcuccc ucgcccuggc gaucauggug gccgggcuga gccucuggau gugcagcaac     1680

ggcucccugc agugccgcau cugcaucuga ggacuaguua uaagacugac uagcccgaug     1740

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     1860

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             1912


<210>  5
<211>  1924
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  5
gggagaaagc uuaccaugga gaagaucgug cugcucuucg ccaucgucag ccuggugaag       60

uccgaccaga ucugcaucgg cuaccacgcc aacaacagca ccgagcaggu ggacaccauc      120

auggagaaga acgucacggu gacccacgcg caggacaucc uggagaagac ccacaacggg      180

aagcucugcg accuggacgg cgugaagccc cugauccucc gggacugcuc cgucgccggg      240

uggcugcugg gcaacccgau gugcgacgag uucaucaacg ugcccgagug gagcuacauc      300

guggagaagg ccaaccccgu caacgaccuc ugcuaccccg gggacuucaa cgacuacgag      360

gagcugaagc accugcucuc ccgcaucaac cacuucgaga agauccagau caucccgaag      420

agcuccugga gcucccacga ggccagccug ggcgugucca gcgccugccc cuaccagggc      480

aaguccagcu ucuuccggaa cguggucugg cugaucaaga agaacuccac cuaccccacg      540

aucaagcgca gcuacaacaa caccaaccag gaggaccucc uggugcugug ggggauccac      600

caccccaacg acgcggccga gcagaccaag cucuaccaga acccgaccac guacaucucc      660

gugggcacca gcacccugaa ccagcggcug gucccccgca ucgccacccg guccaaggug      720

aacgggcaga gcggccgcau ggaguucuuc uggacgaucc ucaagcccaa cgacgccauc      780

aacuucgaga gcaacgggaa cuucaucgcg cccgaguacg ccuacaagau cgugaagaag      840

ggcgacucca ccaucaugaa gagcgagcug gaguacggca acugcaacac caagugccag      900

accccgaugg gggccaucaa cuccagcaug cccuuccaca acauccaccc ccugacgauc      960

ggcgagugcc ccaaguacgu caaguccaac cggcucgugc uggccaccgg gcugcgcaac     1020

agcccgcagc gggagcggcg ccggaagaag cgcggccucu ucggcgccau cgcgggguuc     1080

aucgagggcg gguggcaggg caugguggac gggugguacg gcuaccacca cuccaacgag     1140

cagggcagcg gguacgccgc cgacaaggag uccacccaga aggccaucga cggcgucacg     1200

aacaagguga acagcaucau cgacaagaug aacacccagu ucgaggccgu ggggcgggag     1260

uucaacaacc uggagcgccg gaucgagaac cugaacaaga agauggagga cggcuuccuc     1320

gacgucugga ccuacaacgc ggagcugcug gugcucaugg agaacgagcg cacccuggac     1380

uuccacgacu ccaacgucaa gaaccuguac gacaaggugc ggcuccagcu gcgcgacaac     1440

gccaaggagc uggggaacgg cugcuucgag uucuaccaca agugcgacaa cgagugcaug     1500

gagagcgugc ggaacggcac guacgacuac ccccaguacu ccgaggaggc ccgccucaag     1560

cgggaggaga ucagcggggu caagcuggag uccaucggca ucuaccagau ccugagcauc     1620

uacuccaccg uggccagcuc ccucgcccug gcgaucaugg uggccgggcu gagccucugg     1680

augugcagca acggcucccu gcagugccgc aucugcaucu gaggacuagu uauaagacug     1740

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1920

aauu                                                                  1924


<210>  6
<211>  1924
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  6
gggagaaagc uuaccaugga gaagaucaug cugcuccugg ccaucgugag ccuggucaag       60

uccgaccaga ucugcaucgg cuaccacgcc aacaacagca ccgagcaggu ggacaccauc      120

auggagaaga acgugacggu cacccacgcg caggacaucc ucgagaagac ccacaacggg      180

aagcugugcg accuggacgg cgugaagccc cucauccugc gggacugcuc cguggccggg      240

uggcugcucg gcaacccgau gugcgacgag uuccugaacg uccccgagug gagcuacauc      300

guggagaaga ucaaccccgc caacgaccug ugcuaccccg ggaacuucaa cgacuacgag      360

gagcucaagc accugcuguc ccgcaucaac cacuucgaga agauccagau caucccgaag      420

agcuccugga gcgaccacga ggccuccagc ggcgugucca gcgccugccc cuaccagggc      480

cgguccagcu ucuuccgcaa cgucgugugg cucaucaaga aggacaacgc guaccccacc      540

aucaagcggu ccuacaacaa cacgaaccag gaggaccugc uggugcucug ggggauccac      600

caccccaacg acgccgccga gcagacccgc cuguaccaga acccgaccac cuacaucagc      660

gucggcacgu ccacccugaa ccagcggcuc gugcccaaga ucgccacccg cagcaaggug      720

aacgggcagu ccggccggau ggaguucuuc uggaccaucc ugaagcccaa cgacgcgauc      780

aacuucgaga gcaacgggaa cuucaucgcc cccgagaacg ccuacaagau cgucaagaag      840

ggcgacagca cgaucaugaa guccgagcug gaguacggca acugcaacac caagugccag      900

accccgaucg gggccaucaa cagcuccaug cccuuccaca acauccaccc ccucaccauc      960

ggcgagugcc ccaaguacgu gaagagcaac cgccuggugc uggccacggg gcuccggaac     1020

uccccgcagg gcgagcgccg gcgcaagaag cggggccugu ucggggcgau cgccggcuuc     1080

aucgagggcg gguggcaggg gauggucgac ggcugguacg gcuaccacca cagcaacgag     1140

cagggguccg gcuacgccgc cgacaaggag agcacccaga aggccaucga cggggugacc     1200

aacaagguga acuccaucau cgacaagaug aacacccagu ucgaggcggu cggccgcgag     1260

uucaacaacc uggagcggcg caucgagaac cucaacaaga agauggagga cggguuccug     1320

gacgugugga cguacaacgc cgagcugcuc gugcugaugg agaacgagcg gacccuggac     1380

uuccacgaca gcaacgucaa gaaccucuac gacaaggugc gccugcagcu gcgggacaac     1440

gccaaggagc ucggcaacgg cugcuucgag uucuaccacc gcugcgacaa cgagugcaug     1500

gaguccgucc ggaacgggac cuacgacuac ccccaguaca gcgaggaggc ccggcugaag     1560

cgcgaggaga ucuccggcgu gaagcuggag agcaucggga ccuaccagau ccucuccauc     1620

uacagcacgg uggccuccag ccuggcgcug gccaucaugg ucgccggccu cucccugugg     1680

augugcagca acgggagccu gcagugccgg aucugcaucu gaccacuagu uauaagacug     1740

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1920

aauu                                                                  1924


<210>  7
<211>  1915
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  7
gggagaaagc uuaccaugaa ggugaagcug cucguccugc ugugcaccuu caccgccacg       60

uacgccgaca ccaucugcau cggcuaccac gcgaacaaca gcaccgacac cguggacacg      120

gugcucgaga agaacgucac cgugacccac uccgugaacc ugcuggagaa cagccacaac      180

gggaagcucu gccugcugaa gggcaucgcc ccccuccagc uggggaacug cuccgucgcc      240

ggcuggaucc uggggaaccc ggagugcgag cuccugauca gcaaggaguc cuggagcuac      300

aucguggaga agcccaaccc cgagaacggc accugcuacc ccggccacuu cgccgacuac      360

gaggagcugc gggagcagcu cuccagcgug uccagcuucg agcgcuucga gaucuucccg      420

aaggagucca gcuggcccaa ccacacgguc accggggugu ccgccagcug cucccacaac      480

ggcgagagcu ccuucuaccg gaaccugcug uggcucaccg ggaagaacgg ccuguacccc      540

aaccugagca aguccuacgc gaacaacaag gagaaggagg ugcucguccu guggggcgug      600

caccacccgc cgaacaucgg gaaccagaag gcccuguacc acaccgagaa cgccuacgug      660

agcgucguga gcucccacua cagccgcaag uucacgcccg agaucgccaa gcggcccaag      720

gugcgcgacc aggagggccg gaucaacuac uacuggaccc uccuggagcc cggggacacc      780

aucaucuucg aggcgaacgg caaccugauc gccccgcgcu acgccuucgc ccucucccgg      840

ggguucggca gcggcaucau caacuccaac gccccgaugg acaagugcga cgcgaagugc      900

cagacccccc agggggccau caacagcucc cugcccuucc agaacgucca cccggugacg      960

aucggcgagu gccccaagua cgugcgcagc gccaagcugc ggauggucac cgggcuccgc     1020

aacauccccu ccauccagag ccggggccug uucggggcca ucgccggcuu caucgagggc     1080

ggguggaccg gcauggugga cgggugguac ggcuaccacc accagaacga gcaggggucc     1140

ggcuacgcgg ccgaccagaa gagcacccag aacgccauca acggcaucac gaacaaggug     1200

aacuccguca ucgagaagau gaacacccag uucaccgccg uggggaagga guucaacaag     1260

cuggagcgcc ggauggagaa ccucaacaag aaggucgacg acggcuucau cgacaucugg     1320

accuacaacg ccgagcugcu ggugcuccug gagaacgagc gcacgcugga cuuccacgac     1380

agcaacguga agaaccucua cgagaagguc aagucccagc ugaagaacaa cgcgaaggag     1440

aucgggaacg gcugcuucga guucuaccac aagugcaacg acgagugcau ggagagcgug     1500

aagaacggga ccuacgacua ccccaaguac uccgaggaga gcaagcugaa ccgggagaag     1560

aucgacggcg ugaagcucga guccaugggc gucuaccaga uccuggccau cuacagcacc     1620

guggccagcu cccuggugcu ccuggucagc cugggggcca ucuccuucug gaugugcagc     1680

aacggcuccc ugcagugccg caucugcauc ugaggacuag uuauaagacu gacuagcccg     1740

augggccucc caacgggccc uccuccccuc cuugcaccga gauuaauaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa augcaucccc     1860

cccccccccc cccccccccc cccccccaaa ggcucuuuuc agagccacca gaauu          1915


<210>  8
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  8
gggagaaagc uuaccaugaa gaccaucauc gcccugagcu acauccucug ccugguguuc       60

gcccagaagc ugcccggcaa cgacaacucc accgcgacgc ucugccuggg gcaccacgcc      120

gucccgaacg gcaccaucgu gaagaccauc accaacgacc agaucgaggu gacgaacgcc      180

accgagcugg uccagagcuc cagcaccggg gagaucugcg acucccccca ccagauccuc      240

gacggcgaga acugcacccu gaucgacgcc cugcucgggg acccccagug cgacggcuuc      300

cagaacaaga agugggaccu guucguggag cggagcaagg ccuacuccaa cugcuacccc      360

uacgacgugc cggacuacgc gagccugcgc ucccucgucg ccagcuccgg cacgcuggag      420

uucaacaacg agagcuucaa cuggaccggg gugacccaga acggcaccuc cagcuccugc      480

auccggggga gcaacaacuc cuucuucagc cgccugaacu ggcucacgca ccugaaguuc      540

aaguaccccg cccugaacgu gaccaugccc aacaacgaga aguucgacaa gcucuacauc      600

uggggcgucc accaccccgg gaccgacaac gaccagaucu ucccguacgc ccaggcgucc      660

ggccggauca ccgugagcac gaagcgcagc cagcagaccg ugauccccaa caucggcucc      720

cggccccgcg uccggaacau ccccagccgc aucuccaucu acuggaccau cgugaagccg      780

ggggacaucc ugcugaucaa cagcaccggc aaccucaucg ccccgcgggg guacuucaag      840

auccgcuccg gcaagagcuc caucaugcgg agcgacgccc ccaucggcaa gugcaacucc      900

gagugcauca cgcccaacgg gagcaucccg aacgacaagc ccuuccagaa cgugaaccgc      960

aucaccuacg gcgccugccc ccgguacguc aagcagaaca cccugaagcu ggccaccggg     1020

augcgcaacg ugcccgagaa gcagacgcgg ggcaucuucg gggcgaucgc cggcuucauc     1080

gagaacggcu gggaggggau gguggacggc ugguacgggu uccgccacca gaacuccgag     1140

ggcaucgggc aggccgccga ccucaagagc acccaggccg cgaucgacca gaucaacggc     1200

aagcugaacc ggcugaucgg caagaccaac gagaaguucc accagaucga gaaggaguuc     1260

uccgaggucg aggggcgcau ccaggaccuc gagaaguacg uggaggacac caagaucgac     1320

cuguggagcu acaacgccga gcugcucgug gcccuggaga accagcacac gaucgaccug     1380

accgacuccg agaugaacaa gcucuucgag aagaccaaga agcagcugcg ggagaacgcc     1440

gaggacaugg gcaacgggug cuucaagauc uaccacaagu gcgacaacgc cugcaucggc     1500

agcauccgca acgggaccua cgaccacgac gucuaccggg acgaggcgcu gaacaaccgg     1560

uuccagauca agggcgugga gcucaagucc ggcuacaagg acuggauccu guggaucagc     1620

uucgccaucu ccugcuuccu gcucugcgug gcccugcugg gguucaucau gugggccugc     1680

cagaagggca acauccgcug caacaucugc aucugaggac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  9
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  9
gggagaaagc uuaccaugaa gaccaucauc gcccugagcu acaucuucug ccucgcccug       60

ggccaggacc ugcccgggaa cgacaacucc accgcgacgc ucugccuggg ccaccacgcc      120

gugccgaacg ggacccuggu caagaccauc accgacgacc agaucgaggu gacgaacgcc      180

accgagcucg ugcagagcuc cagcaccggc aagaucugca acaaccccca ccggauccug      240

gacgggaucg acugcacccu gaucgacgcc cuccugggcg acccccacug cgacgucuuc      300

cagaacgaga cgugggaccu guucguggag cgcuccaagg ccuucagcaa cugcuacccc      360

uacgacgugc cggacuacgc gucccuccgg agccuggucg ccuccagcgg cacccuggag      420

uucaucaccg agggguucac cuggacgggc gugacccaga acgggggcuc caacgccugc      480

aagcgcgggc ccggcagcgg cuucuucucc cggcucaacu ggcugaccaa gagcgggucc      540

accuaccccg ugcugaacgu cacgaugccc aacaacgaca acuucgacaa gcucuacauc      600

uggggcgugc accacccgag caccaaccag gagcagaccu cccuguacgu gcaggccagc      660

gggcgcguca ccguguccac gcggcgcagc cagcagacca ucauccccaa caucgagagc      720

cggcccuggg ugcgcggcca guccagccgg aucuccaucu acuggaccau cgucaagccc      780

ggcgacgugc uggugaucaa cagcaacggg aaccucaucg cgccgcgcgg cuacuucaag      840

augcggaccg ggaaguccag caucaugcgc uccgacgccc ccaucgacac gugcaucagc      900

gagugcauca cccccaacgg cuccaucccc aacgacaagc cguuccagaa cgucaacaag      960

aucaccuacg gggccugccc caaguacgug aagcagaaca cccugaagcu ggccacgggc     1020

augcggaacg ugcccgagaa gcagacccgc ggccucuucg gggccaucgc gggcuucauc     1080

gagaacgggu gggagggcau gaucgacggg ugguacggcu uccggcacca gaacagcgag     1140

ggcaccgggc aggccgccga ccugaagucc acccaggccg ccaucgacca gaucaacggc     1200

aaggucaacc gcaucaucga gaagacgaac gagaaguucc accagaucga gaaggaguuc     1260

agcgaggugg aggggcggau ccaggaccug gagaaguacg uggaggacac caagaucgac     1320

cucugguccu acaacgcgga gcugcugguc gcccucgaga accagcacac caucgaccug     1380

accgacagcg agaugaacaa gcuguucgag aagacgcgcc ggcagcuccg cgagaacgcc     1440

gaggacaugg gcaacgggug cuucaagauc uaccacaagu gcgacaacgc cugcaucgag     1500

uccauccgga gcggcaccua cgaccacgac guguaccggg acgaggcccu gaacaaccgc     1560

uuccagauca agggcgucga gcugaagucc ggguacaagg acuggauccu cuggaucagc     1620

uucgcgaucu ccugcuuccu gcugugcgug gugcuccugg gcuucaucau gugggccugc     1680

cagcggggga acauccgcug caacaucugc aucugaggac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  10
<211>  1906
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  10
gggagaaagc uuaccauggc caucaucuac cugauccucc uguucaccgc cgugcggggc       60

gaccagaucu gcaucgggua ccacgcgaac aacagcaccg agaaggucga cacgauccug      120

gagcgcaacg ugaccgugac ccacgccaag gacauccucg agaagaccca caacggcaag      180

cugugcaagc ugaacgggau cccgccgcuc gagcugggcg acugcuccau cgccgggugg      240

cugcucggca accccgagug cgaccggcug cugagcgucc ccgagugguc cuacaucaug      300

gagaaggaga acccccgcga cggccucugc uacccgggga gcuucaacga cuacgaggag      360

cugaagcacc ugcucuccag cgugaagcac uucgagaagg ugaagauccu gcccaaggac      420

cgguggacgc agcacaccac caccggcggg ucccgcgccu gcgccgucag cggcaacccc      480

uccuucuucc ggaacauggu guggcugacg gagaagggga gcaacuaccc cguggcgaag      540

ggcuccuaca acaacaccag cggcgagcag augcucauca ucuggggcgu ccaccacccg      600

aacgacgaga ccgagcagcg cacccuguac cagaacgugg ggacguacgu guccgucggg      660

accagcaccc ugaacaagcg guccaccccc gagaucgcca cgcgccccaa ggugaacggc      720

cagggcgggc ggauggaguu cagcuggacc cuccuggaca ugugggacac caucaacuuc      780

gaguccaccg gcaaccugau cgcccccgag uacggguuca agaucagcaa gcgcggcucc      840

agcgggauca ugaagacgga gggcacccuc gagaacugcg agaccaagug ccagaccccg      900

cugggcgcca ucaacacgac ccugcccuuc cacaacgugc acccccucac caucggggag      960

ugccccaagu acgucaagag cgagaagcug gugcuggcga ccggccuccg gaacgugccg     1020

cagaucgagu cccgcgggcu guucggcgcc aucgccgggu ucaucgaggg cggcuggcag     1080

gggauggucg acggcuggua cggguaccac cacagcaacg accagggcuc cggguacgcc     1140

gccgacaagg agagcacgca gaaggcguuc gacggcauca ccaacaaggu gaacuccgug     1200

aucgagaaga ugaacaccca guucgaggcc gucggcaagg aguucagcaa ccuggagcgg     1260

cgccucgaga accugaacaa gaagauggag gacggguucc uggacgugug gaccuacaac     1320

gccgagcucc uggugcugau ggagaacgag cggacgcucg acuuccacga cuccaacguc     1380

aagaaccugu acgacaaggu gcgcaugcag cugcgggaca acgucaagga gcucggcaac     1440

gggugcuucg aguucuacca caagugcgac gacgagugca ugaacagcgu gaagaacggc     1500

accuacgacu accccaagua cgaggaggag uccaagcuga accgcaacga gaucaagggc     1560

gugaagcuga gcuccauggg ggucuaccag auccucgcca ucuacgccac cguggcgggc     1620

agccuguccc uggccaucau gauggccggg aucagcuucu ggaugugcuc caacggcagc     1680

cugcagugcc ggaucugcau cugaggacua guuauaagac ugacuagccc gaugggccuc     1740

ccaacgggcc cuccuccccu ccuugcaccg agauuaauaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1860

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1906


<210>  11
<211>  1909
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  11
gggagaaagc uuaccaugaa cacccagauc cugguguucg cccucgucgc cgugauccac       60

accaacgcgg acaagaucug ccugggccac cacgccguga gcaacgggac gaaggucaac      120

acccugaccg agcggggcgu ggaggugguc aacgccaccg agacggugga gcgcaccaac      180

auccccaaga ucugcuccaa ggggaagcgg accguggacc ucggccagug cgggcugcug      240

ggcaccauca cgggccagcc gcagugcgac caguuccucg aguucagcgc cgaccugauc      300

aucgagcgcc gggacgggaa cgacgucugc uaccccggca aguucgugaa cggggaggcc      360

cugcgccaga uccuccggaa guccggcggg aucaacaagg agaccauggg cuucaccuac      420

agcggcaucc gcaccaacgg gacgaccucc gcgugccggc gcagcggcuc cagcuucuac      480

gccgagauga aguggcugcu guccgacacc gacaacgccg ccuuccccca gaugaccaag      540

agcuacaaga acacgcggcg cgagcccgcg cucaucgugu gggggaucca ccacuccggc      600

agcaccaccg agcagaccaa gcuguacggc uccgggaaca agcuggucac ggugggcagc      660

uccaaguacc agcagagcuu cgugccgucc cccgagaccc ggccccaggu caacgggcag      720

agcggccgca ucgacuucca cuggcucauc cuggacucca acgacaccgu gaccuucagc      780

uucaacgggg ccuucaucgc ccccgaccgg gccagcuucc ugaagggcaa guccaugggc      840

auccagagcg acgugcaggu cgacgccaac ugcgaggggg agugcuacca cuccggcggg      900

acgaucacca gcucccuccc guuccagaac aucaacagcc gcgcgguggg caagugcccc      960

cgguacguga agcaggaguc ccugcugcuc gccaccggga ugaagaacgu ccccgagcug     1020

agcaagaagc gccggaagcg cggccuguuc ggcgccaucg ccggguucau cgagaacggc     1080

ugggaggggc ucguggacgg cugguacggg uuccggcacc agaacgccca gggcgagggc     1140

accgcggccg acuacaaguc cacgcagagc gccaucgacc agaucaccgg gaagcugaac     1200

cgccugaucg agaagaccaa ccagcaguuc gagcucaucg acaacgaguu caccgaggug     1260

gagaagcaga ucggcaacgu caucaacugg acgcgggacu ccaucaccga gguguggagc     1320

uacaacgccg agcugcuggu cgccauggag aaccagcaca ccaucgaccu cgcggacucc     1380

gagaugaaca agcuguacga gcgggugcgc aagcagcugc gggagaacgc cgaggaggac     1440

gggaccggcu gcuucgagau cuuccacaag ugcgacgacg acugcauggc cagcauccgc     1500

aacaacacgu acgaccacuc caaguaccgg gaggaggcca ugcagaaccg cauccagauc     1560

gaccccguga agcucagcgg cggguacaag gacgucaucc ugugguucuc cuucggcgcc     1620

agcugcuucc ugcuccuggc gaucgccaug gggcuggugu ucaucugcgu gaagaacggc     1680

aacaugcggu gcaccaucug caucugacca cuaguuauaa gacugacuag cccgaugggc     1740

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1860

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1909


<210>  12
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  12
gggagaaagc uuaccaugaa ggccauccug gugguccucc uguacaccuu cgccaccgcg       60

aacgccgaca cgcugugcau cggcuaccac gccaacaaca gcaccgacac cguggacacc      120

gugcucgaga agaacgucac ggugacccac uccgugaacc ugcuggagga caagcacaac      180

gggaagcucu gcaagcugcg gggcgucgcc ccgcugcacc ucgggaagug caacaucgcc      240

ggcuggaucc uggggaaccc ggagugcgag agccugucca ccgcgagcuc cuggagcuac      300

aucguggaga ccuccuccag cgacaacggc acgugcuacc ccggcgacuu caucgacuac      360

gaggagcucc gcgagcagcu guccagcgug uccagcuucg agcgguucga gaucuucccc      420

aagaccucca gcuggccgaa ccacgacucc aacaaggggg ucaccgccgc cugcccccac      480

gccggcgcga agagcuucua caagaaccug aucuggcucg ugaagaaggg gaacuccuac      540

cccaagcuga gcaaguccua caucaacgac aagggcaagg aggugcuggu ccucuggggg      600

auccaccacc ccagcaccag cgccgaccag cagucccugu accagaacgc cgacgccuac      660

guguucgugg gcagcucccg cuacagcaag aaguucaagc cggagaucgc cauccggccc      720

aagguccgcg accaggaggg ccgcaugaac uacuacugga cccuggugga gcccggggac      780

aagaucaccu ucgaggcgac cggcaaccuc gugguccccc gguacgccuu cgccauggag      840

cgcaacgccg gguccggcau caucaucagc gacacgccgg ugcacgacug caacaccacc      900

ugccagaccc ccaagggcgc caucaacacg ucccugcccu uccagaacau ccaccccauc      960

accaucggga agugcccgaa guacgugaag agcaccaagc ugcggcucgc gaccggccug     1020

cgcaacgucc ccuccaucca gagccggggg cuguucggcg ccaucgccgg guucaucgag     1080

ggcggcugga cggggauggu cgacggcugg uacggguacc accaccagaa cgagcagggc     1140

agcggguacg ccgccgaccu caaguccacg cagaacgcga ucgacgagau caccaacaag     1200

gugaacagcg ucaucgagaa gaugaacacc caguucaccg ccgugggcaa ggaguucaac     1260

caccuggaga agcggaucga gaaccugaac aagaaggucg acgacggcuu ccucgacauc     1320

uggacguaca acgccgagcu gcuggugcuc cuggagaacg agcgcacccu ggacuaccac     1380

gacuccaacg ugaagaaccu cuacgagaag guccggagcc agcugaagaa caacgccaag     1440

gagaucggga acggcugcuu cgaguucuac cacaagugcg acaacaccug cauggagucc     1500

gugaagaacg ggaccuacga cuaccccaag uacagcgagg aggccaagcu gaaccgcgag     1560

gagaucgacg gcgugaagcu cgaguccacg cggaucuacc agauccuggc gaucuacagc     1620

accgucgcca gcucccuggu gcucgugguc agccuggggg ccaucuccuu cuggaugugc     1680

agcaacggcu cccugcagug ccgcaucugc aucugaccac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  13
<211>  1975
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  13
gggagaaagc uuaccaugaa ggccaucauc gugcugcuca uggucgugac cagcaacgcc       60

gaccggaucu gcaccggcau cacguccagc aacuccccgc acguggucaa gaccgcgacc      120

cagggggagg ugaacgugac cggcgucauc ccgcugacga ccacccccac caagagccac      180

uucgccaacc ugaaggggac ggagacccgc ggcaagcucu gccccaagug ccugaacugc      240

accgaccugg acguggcccu cgggcggccc aagugcaccg gcaagauccc guccgcccgc      300

gugagcaucc ugcacgaggu ccggcccgug acguccggcu gcuuccccau caugcacgac      360

cgcaccaaga uccggcagcu gcccaaccuc cugcgcgggu acgagcacau ccggcugagc      420

acccacaacg ugaucaacgc cgagaacgcg ccgggcgggc ccuacaagau cggcaccucc      480

gggagcugcc ccaacaucac gaacggcaac ggcuucuucg ccaccauggc cugggccguc      540

cccaagaacg acaagaacaa gaccgcgacc aacccgcuca cgaucgaggu gcccuacauc      600

ugcaccgagg gggaggacca gaucaccgug uggggcuucc acuccgacaa cgagacccag      660

auggccaagc uguacgggga cagcaagccc cagaaguuca cguccagcgc caacggcguc      720

accacccacu acguguccca gaucggcggg uuccccaacc agaccgagga cggcgggcug      780

ccgcagagcg gccgcaucgu ggucgacuac auggugcaga aguccgggaa gacgggcacc      840

aucaccuacc agcggggcau ccuccugccc cagaaggugu ggugcgccag cgggcgcucc      900

aaggucauca agggcagccu gccccucauc ggggaggccg acugccugca cgagaaguac      960

ggcgggcuga acaagagcaa gcccuacuac accggcgagc acgcgaaggc caucggcaac     1020

ugcccgaucu gggugaagac gccccucaag cuggccaacg ggaccaagua ccggcccccc     1080

gccaagcugc ucaaggagcg cggcuucuuc ggggccaucg cgggcuuccu ggagggcggg     1140

ugggagggca ugaucgccgg guggcacggc uacaccuccc acggggccca cggcguggcc     1200

gucgccgcgg accugaagag cacccaggag gccaucaaca agaucacgaa gaaccucaac     1260

ucccugagcg agcuggaggu gaagaaccuc cagcggcugu ccggcgccau ggacgagcug     1320

cacaacgaga uccucgagcu ggacgagaag gucgacgacc ugcgcgccga caccaucagc     1380

ucccagaucg agcucgccgu gcugcugagc aacgagggga ucaucaacuc cgaggacgag     1440

caccuccugg cgcuggagcg gaagcucaag aagaugcugg gcccgagcgc cguggagauc     1500

gggaacggcu gcuucgagac caagcacaag ugcaaccaga ccugccugga ccgcaucgcc     1560

gccgggaccu ucgacgcggg cgaguucucc cuccccacgu ucgacagccu gaacaucacc     1620

gccgccuccc ugaacgacga cggccuggac aaccacacca uccuccugua cuacagcacc     1680

gccgccucca gccuggcggu cacgcucaug aucgccaucu ucguggugua cauggucucc     1740

cgggacaacg ugagcugcuc caucugccug ugaggacuag uuauaagacu gacuagcccg     1800

augggccucc caacgggccc uccuccccuc cuugcaccga gauuaauaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa augcaucccc     1920

cccccccccc cccccccccc cccccccaaa ggcucuuuuc agagccacca gaauu          1975


<210>  14
<211>  1918
<212>  RNA
<213>  Artificial sequnece

<220>
<223>  GC optimized HA mRNA

<400>  14
gggagaaagc uuaccaugaa ggccauccug gugguccucc uguacaccuu cgccaccgcg       60

aacgccgaca cgcugugcau cggcuaccac gccaacaaca gcaccgacac cguggacacc      120

gugcucgaga agaacgucac ggugacccac uccgugaacc ugcuggagga caagcacaac      180

gggaagcucu gcaagcugcg gggcgucgcc ccgcugcacc ucgggaagug caacaucgcc      240

ggcuggaucc uggggaaccc ggagugcgag agccugucca ccgcgagcuc cuggagcuac      300

aucguggaga cccccagcuc cgacaacggc acgugcuacc ccggcgacuu caucgacuac      360

gaggagcucc gcgagcagcu gagcuccgug agcuccuucg agcgguucga gaucuucccc      420

aagaccagcu ccuggcccaa ccacgacagc gacaaggggg ucaccgccgc cugcccgcac      480

gccggcgcga aguccuucua caagaaccug aucuggcucg ugaagaaggg gaacagcuac      540

cccaagcugu ccaagagcua caucaacgac aagggcaagg aggugcuggu ccucuggggg      600

auccaccacc ccagcaccuc cgccgaccag cagagccugu accagaacgc cgacgccuac      660

guguucgugg gcuccagccg cuacuccaag acguucaagc ccgagaucgc cauccggccg      720

aagguccgcg accgggaggg ccggaugaac uacuacugga cgcuggugga gcccggggac      780

aagaucaccu ucgaggcgac cggcaaccuc gugguccccc gcuacgccuu cgccauggag      840

cggaacgccg ggagcggcau caucaucucc gacacccccg ugcacgacug caacacgacc      900

ugccagaccc cgaagggcgc caucaacacc agccugcccu uccagaacau ccaccccauc      960

acgaucggga agugccccaa guacgugaag uccaccaagc ugcgccucgc gaccggccug     1020

cggaacaucc cgagcaucca gucccgcggg cuguucggcg ccaucgccgg guucaucgag     1080

ggcggcugga ccgggauggu ggacggcugg uacggguacc accaccagaa cgagcagggc     1140

agcggguacg ccgccgaccu caaguccacg cagaacgcga ucgacgagau caccaacaag     1200

gugaacagcg ucaucgagaa gaugaacacc caguucaccg ccgugggcaa ggaguucaac     1260

caccuggaga agcggaucga gaaccugaac aagaaggucg acgacggcuu ccucgacauc     1320

uggacguaca acgccgagcu gcuggugcuc cuggagaacg agcgcacccu ggacuaccac     1380

gacuccaacg ugaagaaccu cuacgagaag guccggagcc agcugaagaa caacgccaag     1440

gagaucggga acggcugcuu cgaguucuac cacaagugcg acaacaccug cauggagucc     1500

gugaagaacg ggaccuacga cuaccccaag uacagcgagg aggccaagcu gaaccgcgag     1560

gagaucgacg gcgugaagcu cgaguccacg cggaucuacc agauccuggc gaucuacagc     1620

accgucgcca gcucccuggu gcucgugguc agccuggggg ccaucuccuu cuggaugugc     1680

agcaacggcu cccugcagug ccgcaucugc aucugaccac uaguuauaag acugacuagc     1740

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1860

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1918


<210>  15
<211>  3952
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  15
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccaacc     2040

tgctcgtgct gctgtgcgcc ctcgcggccg ccgacgccga caccatctgc atcggctacc     2100

acgccaacaa cagcaccgac acggtcgaca ccgtgctgga gaagaacgtg accgtcaccc     2160

actccgtgaa cctgctcgag gacagccaca acgggaagct gtgccggctg aagggcatcg     2220

cgcccctcca gctggggaag tgcaacatcg ccggctggct gctcgggaac ccggagtgcg     2280

accccctgct gcccgtgcgc tcctggagct acatcgtcga gacgcccaac tccgagaacg     2340

gcatctgcta cccgggcgac ttcatcgact acgaggagct ccgggagcag ctgagctccg     2400

tgagctcctt cgagcgcttc gagatcttcc ccaaggagag ctcctggccc aaccacaaca     2460

ccaacggggt gaccgccgcc tgcagccacg agggcaagtc cagcttctac cggaacctgc     2520

tctggctgac cgagaaggag gggtcctacc ccaagctgaa gaacagctac gtcaacaaga     2580

agggcaagga ggtgctcgtg ctgtggggga tccaccaccc gcccaactcc aaggagcagc     2640

agaacctgta ccagaacgag aacgcgtacg tcagcgtggt gacgtccaac tacaaccgcc     2700

ggttcacccc cgagatcgcc gagcgcccca aggtccggga ccaggccggc cgcatgaact     2760

actactggac cctcctgaag ccgggcgaca ccatcatctt cgaggccaac gggaacctga     2820

tcgccccgat gtacgcgttc gccctcagcc ggggcttcgg gagcggcatc atcacgtcca     2880

acgccagcat gcacgagtgc aacaccaagt gccagacccc cctgggcgcc atcaactcca     2940

gcctgcccta ccagaacatc cacccggtga ccatcgggga gtgccccaag tacgtgcgct     3000

ccgccaagct ccggatggtc acgggcctgc gcaacaaccc cagcatccag tcccgggggc     3060

tgttcggcgc gatcgccggg ttcatcgagg gcggctggac cgggatgatc gacggctggt     3120

acgggtacca ccaccagaac gagcagggca gcgggtacgc cgccgaccag aagtccaccc     3180

agaacgccat caacggcatc accaacaagg tgaacacggt gatcgagaag atgaacatcc     3240

agttcaccgc ggtcggcaag gagttcaaca agctcgagaa gcgcatggag aacctgaaca     3300

agaaggtgga cgacgggttc ctggacatct ggacctacaa cgccgagctc ctggtgctgc     3360

tcgagaacga gcggaccctg gacttccacg acagcaacgt caagaacctg tacgagaagg     3420

tgaagtccca gctcaagaac aacgccaagg agatcggcaa cgggtgcttc gagttctacc     3480

acaagtgcga caacgagtgc atggagagcg tccgcaacgg cacgtacgac taccccaagt     3540

actccgagga gagcaagctg aaccgggaga aggtggacgg ggtgaagctg gagtccatgg     3600

gcatctacca gatcctcgcc atctacagca ccgtcgcctc cagcctggtg ctgctggtgt     3660

ccctcggcgc gatcagcttc tggatgtgca gcaacgggtc cctgcagtgc cgcatctgca     3720

tctgaccact agttataaga ctgactagcc cgatgggcct cccaacgggc cctcctcccc     3780

tccttgcacc gagattaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaatgcatcc cccccccccc cccccccccc ccccccccca     3900

aaggctcttt tcagagccac cagaattcgg atactctaga catatgctta ag             3952


<210>  16
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  16
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccatcc     2040

tggtggtcct cctgtacacc ttcgccaccg cgaacgccga cacgctgtgc atcggctacc     2100

acgccaacaa cagcaccgac accgtggaca ccgtgctcga gaagaacgtc acggtgaccc     2160

actccgtgaa cctgctggag gacaagcaca acgggaagct ctgcaagctg cggggcgtcg     2220

ccccgctgca cctcgggaag tgcaacatcg ccggctggat cctggggaac ccggagtgcg     2280

agagcctgtc caccgcgagc tcctggagct acatcgtgga gacctccagc tccgacaacg     2340

gcacgtgcta ccccggcgac ttcatcgact acgaggagct ccgcgagcag ctgagctccg     2400

tgagctcctt cgagcggttc gagatcttcc ccaagaccag ctcctggccc aaccacgaca     2460

gcaacaaggg ggtcaccgcc gcctgcccgc acgccggcgc gaagtccttc tacaagaacc     2520

tgatctggct cgtgaagaag gggaacagct accccaagct gtccaagagc tacatcaacg     2580

acaagggcaa ggaggtgctg gtcctctggg ggatccacca ccccagcacc tccgccgacc     2640

agcagagcct gtaccagaac gccgacgcct acgtgttcgt gggctccagc cgctactcca     2700

agaagttcaa gcccgagatc gccatccggc cgaaggtccg cgaccaggag ggccggatga     2760

actactactg gacgctggtg gagcccgggg acaagatcac cttcgaggcg accggcaacc     2820

tcgtggtccc ccgctacgcc ttcgccatgg agcggaacgc cgggagcggc atcatcatct     2880

ccgacacccc cgtgcacgac tgcaacacga cctgccagac cccgaagggc gccatcaaca     2940

ccagcctgcc cttccagaac atccacccca tcacgatcgg gaagtgcccc aagtacgtga     3000

agtccaccaa gctgcgcctc gcgaccggcc tgcggaacgt cccgagcatc cagtcccgcg     3060

ggctgttcgg cgccatcgcc gggttcatcg agggcggctg gaccgggatg gtggacggct     3120

ggtacgggta ccaccaccag aacgagcagg gcagcgggta cgccgccgac ctcaagtcca     3180

cgcagaacgc gatcgacgag atcaccaaca aggtgaacag cgtcatcgag aagatgaaca     3240

cccagttcac cgccgtgggc aaggagttca accacctgga gaagcggatc gagaacctga     3300

acaagaaggt cgacgacggc ttcctcgaca tctggacgta caacgccgag ctgctggtgc     3360

tcctggagaa cgagcgcacc ctggactacc acgactccaa cgtgaagaac ctctacgaga     3420

aggtccggag ccagctgaag aacaacgcca aggagatcgg gaacggctgc ttcgagttct     3480

accacaagtg cgacaacacc tgcatggagt ccgtgaagaa cgggacctac gactacccca     3540

agtacagcga ggaggccaag ctgaaccgcg aggagatcga cggcgtgaag ctcgagtcca     3600

cgcggatcta ccagatcctg gcgatctaca gcaccgtcgc cagctccctg gtgctcgtgg     3660

tcagcctggg ggccatctcc ttctggatgt gcagcaacgg ctccctgcag tgccgcatct     3720

gcatctgacc actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


<210>  17
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  17
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccatcc     2040

tggtggtcct cctgtacacc ttcgccaccg cgaacgccga cacgctgtgc atcggctacc     2100

acgccaacaa cagcaccgac accgtggaca ccgtgctcga gaagaacgtc acggtgaccc     2160

actccgtgaa cctgctggag gacaagcaca acgggaagct ctgcaagctg cggggcgtcg     2220

ccccgctgca cctcgggaag tgcaacatcg ccggctggat cctggggaac ccggagtgcg     2280

agagcctgtc caccgcgagc tcctggagct acatcgtgga gaccccctcc agcgacaacg     2340

gcacgtgcta ccccggcgac ttcatcgact acgaggagct ccgcgagcag ctgtccagcg     2400

tgtccagctt cgagcggttc gagatcttcc ccaagacctc cagctggccg aaccacgact     2460

ccgacaaggg ggtcaccgcc gcctgccccc acgccggcgc gaagagcttc tacaagaacc     2520

tgatctggct cgtgaagaag gggaactcct accccaagct gagcaagtcc tacatcaacg     2580

acaagggcaa ggaggtgctg gtcctctggg ggatccacca ccccagcacc agcgccgacc     2640

agcagtccct gtaccagaac gccgacgcct acgtgttcgt gggcagctcc cgctacagca     2700

agacgttcaa gccggagatc gccatccggc ccaaggtccg cgaccgggag ggccgcatga     2760

actactactg gaccctggtg gagcccgggg acaagatcac cttcgaggcg accggcaacc     2820

tcgtggtccc ccggtacgcc ttcgccatgg agcgcaacgc cgggtccggc atcatcatca     2880

gcgacacgcc ggtgcacgac tgcaacacca cctgccagac ccccaagggc gccatcaaca     2940

cgtccctgcc cttccagaac atccacccca tcaccatcgg gaagtgcccg aagtacgtga     3000

agagcaccaa gctgcggctc gcgaccggcc tgcgcaacat cccctccatc cagagccggg     3060

ggctgttcgg cgccatcgcc gggttcatcg agggcggctg gacggggatg gtcgacggct     3120

ggtacgggta ccaccaccag aacgagcagg gcagcgggta cgccgccgac ctcaagtcca     3180

cgcagaacgc gatcgacgag atcaccaaca aggtgaacag cgtcatcgag aagatgaaca     3240

cccagttcac cgccgtgggc aaggagttca accacctgga gaagcggatc gagaacctga     3300

acaagaaggt cgacgacggc ttcctcgaca tctggacgta caacgccgag ctgctggtgc     3360

tcctggagaa cgagcgcacc ctggactacc acgactccaa cgtgaagaac ctctacgaga     3420

aggtccggag ccagctgaag aacaacgcca aggagatcgg gaacggctgc ttcgagttct     3480

accacaagtg cgacaacacc tgcatggagt ccgtgaagaa cgggacctac gactacccca     3540

agtacagcga ggaggccaag ctgaaccgcg aggagatcga cggcgtgaag ctcgagtcca     3600

cgcggatcta ccagatcctg gcgatctaca gcaccgtcgc cagctccctg gtgctcgtgg     3660

tcagcctggg ggccatctcc ttctggatgt gcagcaacgg ctccctgcag tgccgcatct     3720

gcatctgacc actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


<210>  18
<211>  3949
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  18
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg gagaagatcg     2040

tgctgctctt cgccatcgtc agcctggtga agtccgacca gatctgcatc ggctaccacg     2100

ccaacaacag caccgagcag gtggacacca tcatggagaa gaacgtcacg gtgacccacg     2160

cgcaggacat cctggagaag acccacaacg ggaagctctg cgacctggac ggcgtgaagc     2220

ccctgatcct ccgggactgc tccgtcgccg ggtggctgct gggcaacccg atgtgcgacg     2280

agttcatcaa cgtgcccgag tggagctaca tcgtggagaa ggccaacccc gtcaacgacc     2340

tctgctaccc cggggacttc aacgactacg aggagctgaa gcacctgctc tcccgcatca     2400

accacttcga gaagatccag atcatcccga agagctcctg gagctcccac gaggccagcc     2460

tgggcgtgtc cagcgcctgc ccctaccagg gcaagtccag cttcttccgg aacgtggtct     2520

ggctgatcaa gaagaactcc acctacccca cgatcaagcg cagctacaac aacaccaacc     2580

aggaggacct cctggtgctg tgggggatcc accaccccaa cgacgcggcc gagcagacca     2640

agctctacca gaacccgacc acgtacatct ccgtgggcac cagcaccctg aaccagcggc     2700

tggtcccccg catcgccacc cggtccaagg tgaacgggca gagcggccgc atggagttct     2760

tctggacgat cctcaagccc aacgacgcca tcaacttcga gagcaacggg aacttcatcg     2820

cgcccgagta cgcctacaag atcgtgaaga agggcgactc caccatcatg aagagcgagc     2880

tggagtacgg caactgcaac accaagtgcc agaccccgat gggggccatc aactccagca     2940

tgcccttcca caacatccac cccctgacga tcggcgagtg ccccaagtac gtcaagtcca     3000

accggctcgt gctggccacc gggctgcgca acagcccgca gcgggagacc cgcggcctct     3060

tcggcgccat cgcggggttc atcgagggcg ggtggcaggg catggtggac gggtggtacg     3120

gctaccacca ctccaacgag cagggcagcg ggtacgccgc cgacaaggag tccacccaga     3180

aggccatcga cggcgtcacg aacaaggtga acagcatcat cgacaagatg aacacccagt     3240

tcgaggccgt ggggcgggag ttcaacaacc tggagcgccg gatcgagaac ctgaacaaga     3300

agatggagga cggcttcctc gacgtctgga cctacaacgc ggagctgctg gtgctcatgg     3360

agaacgagcg caccctggac ttccacgact ccaacgtcaa gaacctgtac gacaaggtgc     3420

ggctccagct gcgcgacaac gccaaggagc tggggaacgg ctgcttcgag ttctaccaca     3480

agtgcgacaa cgagtgcatg gagagcgtgc ggaacggcac gtacgactac ccccagtact     3540

ccgaggaggc ccgcctcaag cgggaggaga tcagcggggt caagctggag tccatcggca     3600

tctaccagat cctgagcatc tactccaccg tggccagctc cctcgccctg gcgatcatgg     3660

tggccgggct gagcctctgg atgtgcagca acggctccct gcagtgccgc atctgcatct     3720

gaggactagt tataagactg actagcccga tgggcctccc aacgggccct cctcccctcc     3780

ttgcaccgag attaataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa tgcatccccc cccccccccc cccccccccc ccccccaaag     3900

gctcttttca gagccaccag aattcggata ctctagacat atgcttaag                 3949


<210>  19
<211>  3961
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  19
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg gagaagatcg     2040

tgctgctctt cgccatcgtc agcctggtga agtccgacca gatctgcatc ggctaccacg     2100

ccaacaacag caccgagcag gtggacacca tcatggagaa gaacgtcacg gtgacccacg     2160

cgcaggacat cctggagaag acccacaacg ggaagctctg cgacctggac ggcgtgaagc     2220

ccctgatcct ccgggactgc tccgtcgccg ggtggctgct gggcaacccg atgtgcgacg     2280

agttcatcaa cgtgcccgag tggagctaca tcgtggagaa ggccaacccc gtcaacgacc     2340

tctgctaccc cggggacttc aacgactacg aggagctgaa gcacctgctc tcccgcatca     2400

accacttcga gaagatccag atcatcccga agagctcctg gagctcccac gaggccagcc     2460

tgggcgtgtc cagcgcctgc ccctaccagg gcaagtccag cttcttccgg aacgtggtct     2520

ggctgatcaa gaagaactcc acctacccca cgatcaagcg cagctacaac aacaccaacc     2580

aggaggacct cctggtgctg tgggggatcc accaccccaa cgacgcggcc gagcagacca     2640

agctctacca gaacccgacc acgtacatct ccgtgggcac cagcaccctg aaccagcggc     2700

tggtcccccg catcgccacc cggtccaagg tgaacgggca gagcggccgc atggagttct     2760

tctggacgat cctcaagccc aacgacgcca tcaacttcga gagcaacggg aacttcatcg     2820

cgcccgagta cgcctacaag atcgtgaaga agggcgactc caccatcatg aagagcgagc     2880

tggagtacgg caactgcaac accaagtgcc agaccccgat gggggccatc aactccagca     2940

tgcccttcca caacatccac cccctgacga tcggcgagtg ccccaagtac gtcaagtcca     3000

accggctcgt gctggccacc gggctgcgca acagcccgca gcgggagcgg cgccggaaga     3060

agcgcggcct cttcggcgcc atcgcggggt tcatcgaggg cgggtggcag ggcatggtgg     3120

acgggtggta cggctaccac cactccaacg agcagggcag cgggtacgcc gccgacaagg     3180

agtccaccca gaaggccatc gacggcgtca cgaacaaggt gaacagcatc atcgacaaga     3240

tgaacaccca gttcgaggcc gtggggcggg agttcaacaa cctggagcgc cggatcgaga     3300

acctgaacaa gaagatggag gacggcttcc tcgacgtctg gacctacaac gcggagctgc     3360

tggtgctcat ggagaacgag cgcaccctgg acttccacga ctccaacgtc aagaacctgt     3420

acgacaaggt gcggctccag ctgcgcgaca acgccaagga gctggggaac ggctgcttcg     3480

agttctacca caagtgcgac aacgagtgca tggagagcgt gcggaacggc acgtacgact     3540

acccccagta ctccgaggag gcccgcctca agcgggagga gatcagcggg gtcaagctgg     3600

agtccatcgg catctaccag atcctgagca tctactccac cgtggccagc tccctcgccc     3660

tggcgatcat ggtggccggg ctgagcctct ggatgtgcag caacggctcc ctgcagtgcc     3720

gcatctgcat ctgaggacta gttataagac tgactagccc gatgggcctc ccaacgggcc     3780

ctcctcccct ccttgcaccg agattaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatgcatccc cccccccccc cccccccccc     3900

ccccccccaa aggctctttt cagagccacc agaattcgga tactctagac atatgcttaa     3960

g                                                                     3961


<210>  20
<211>  3961
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  20
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg gagaagatca     2040

tgctgctcct ggccatcgtg agcctggtca agtccgacca gatctgcatc ggctaccacg     2100

ccaacaacag caccgagcag gtggacacca tcatggagaa gaacgtgacg gtcacccacg     2160

cgcaggacat cctcgagaag acccacaacg ggaagctgtg cgacctggac ggcgtgaagc     2220

ccctcatcct gcgggactgc tccgtggccg ggtggctgct cggcaacccg atgtgcgacg     2280

agttcctgaa cgtccccgag tggagctaca tcgtggagaa gatcaacccc gccaacgacc     2340

tgtgctaccc cgggaacttc aacgactacg aggagctcaa gcacctgctg tcccgcatca     2400

accacttcga gaagatccag atcatcccga agagctcctg gagcgaccac gaggcctcca     2460

gcggcgtgtc cagcgcctgc ccctaccagg gccggtccag cttcttccgc aacgtcgtgt     2520

ggctcatcaa gaaggacaac gcgtacccca ccatcaagcg gtcctacaac aacacgaacc     2580

aggaggacct gctggtgctc tgggggatcc accaccccaa cgacgccgcc gagcagaccc     2640

gcctgtacca gaacccgacc acctacatca gcgtcggcac gtccaccctg aaccagcggc     2700

tcgtgcccaa gatcgccacc cgcagcaagg tgaacgggca gtccggccgg atggagttct     2760

tctggaccat cctgaagccc aacgacgcga tcaacttcga gagcaacggg aacttcatcg     2820

cccccgagaa cgcctacaag atcgtcaaga agggcgacag cacgatcatg aagtccgagc     2880

tggagtacgg caactgcaac accaagtgcc agaccccgat cggggccatc aacagctcca     2940

tgcccttcca caacatccac cccctcacca tcggcgagtg ccccaagtac gtgaagagca     3000

accgcctggt gctggccacg gggctccgga actccccgca gggcgagcgc cggcgcaaga     3060

agcggggcct gttcggggcg atcgccggct tcatcgaggg cgggtggcag gggatggtcg     3120

acggctggta cggctaccac cacagcaacg agcaggggtc cggctacgcc gccgacaagg     3180

agagcaccca gaaggccatc gacggggtga ccaacaaggt gaactccatc atcgacaaga     3240

tgaacaccca gttcgaggcg gtcggccgcg agttcaacaa cctggagcgg cgcatcgaga     3300

acctcaacaa gaagatggag gacgggttcc tggacgtgtg gacgtacaac gccgagctgc     3360

tcgtgctgat ggagaacgag cggaccctgg acttccacga cagcaacgtc aagaacctct     3420

acgacaaggt gcgcctgcag ctgcgggaca acgccaagga gctcggcaac ggctgcttcg     3480

agttctacca ccgctgcgac aacgagtgca tggagtccgt ccggaacggg acctacgact     3540

acccccagta cagcgaggag gcccggctga agcgcgagga gatctccggc gtgaagctgg     3600

agagcatcgg gacctaccag atcctctcca tctacagcac ggtggcctcc agcctggcgc     3660

tggccatcat ggtcgccggc ctctccctgt ggatgtgcag caacgggagc ctgcagtgcc     3720

ggatctgcat ctgaccacta gttataagac tgactagccc gatgggcctc ccaacgggcc     3780

ctcctcccct ccttgcaccg agattaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatgcatccc cccccccccc cccccccccc     3900

ccccccccaa aggctctttt cagagccacc agaattcgga tactctagac atatgcttaa     3960

g                                                                     3961


<210>  21
<211>  3952
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  21
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggtgaagc     2040

tgctcgtcct gctgtgcacc ttcaccgcca cgtacgccga caccatctgc atcggctacc     2100

acgcgaacaa cagcaccgac accgtggaca cggtgctcga gaagaacgtc accgtgaccc     2160

actccgtgaa cctgctggag aacagccaca acgggaagct ctgcctgctg aagggcatcg     2220

cccccctcca gctggggaac tgctccgtcg ccggctggat cctggggaac ccggagtgcg     2280

agctcctgat cagcaaggag tcctggagct acatcgtgga gaagcccaac cccgagaacg     2340

gcacctgcta ccccggccac ttcgccgact acgaggagct gcgggagcag ctctccagcg     2400

tgtccagctt cgagcgcttc gagatcttcc cgaaggagtc cagctggccc aaccacacgg     2460

tcaccggggt gtccgccagc tgctcccaca acggcgagag ctccttctac cggaacctgc     2520

tgtggctcac cgggaagaac ggcctgtacc ccaacctgag caagtcctac gcgaacaaca     2580

aggagaagga ggtgctcgtc ctgtggggcg tgcaccaccc gccgaacatc gggaaccaga     2640

aggccctgta ccacaccgag aacgcctacg tgagcgtcgt gagctcccac tacagccgca     2700

agttcacgcc cgagatcgcc aagcggccca aggtgcgcga ccaggagggc cggatcaact     2760

actactggac cctcctggag cccggggaca ccatcatctt cgaggcgaac ggcaacctga     2820

tcgccccgcg ctacgccttc gccctctccc gggggttcgg cagcggcatc atcaactcca     2880

acgccccgat ggacaagtgc gacgcgaagt gccagacccc ccagggggcc atcaacagct     2940

ccctgccctt ccagaacgtc cacccggtga cgatcggcga gtgccccaag tacgtgcgca     3000

gcgccaagct gcggatggtc accgggctcc gcaacatccc ctccatccag agccggggcc     3060

tgttcggggc catcgccggc ttcatcgagg gcgggtggac cggcatggtg gacgggtggt     3120

acggctacca ccaccagaac gagcaggggt ccggctacgc ggccgaccag aagagcaccc     3180

agaacgccat caacggcatc acgaacaagg tgaactccgt catcgagaag atgaacaccc     3240

agttcaccgc cgtggggaag gagttcaaca agctggagcg ccggatggag aacctcaaca     3300

agaaggtcga cgacggcttc atcgacatct ggacctacaa cgccgagctg ctggtgctcc     3360

tggagaacga gcgcacgctg gacttccacg acagcaacgt gaagaacctc tacgagaagg     3420

tcaagtccca gctgaagaac aacgcgaagg agatcgggaa cggctgcttc gagttctacc     3480

acaagtgcaa cgacgagtgc atggagagcg tgaagaacgg gacctacgac taccccaagt     3540

actccgagga gagcaagctg aaccgggaga agatcgacgg cgtgaagctc gagtccatgg     3600

gcgtctacca gatcctggcc atctacagca ccgtggccag ctccctggtg ctcctggtca     3660

gcctgggggc catctccttc tggatgtgca gcaacggctc cctgcagtgc cgcatctgca     3720

tctgaggact agttataaga ctgactagcc cgatgggcct cccaacgggc cctcctcccc     3780

tccttgcacc gagattaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaatgcatcc cccccccccc cccccccccc ccccccccca     3900

aaggctcttt tcagagccac cagaattcgg atactctaga catatgctta ag             3952


<210>  22
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  22
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aagaccatca     2040

tcgccctgag ctacatcctc tgcctggtgt tcgcccagaa gctgcccggc aacgacaact     2100

ccaccgcgac gctctgcctg gggcaccacg ccgtcccgaa cggcaccatc gtgaagacca     2160

tcaccaacga ccagatcgag gtgacgaacg ccaccgagct ggtccagagc tccagcaccg     2220

gggagatctg cgactccccc caccagatcc tcgacggcga gaactgcacc ctgatcgacg     2280

ccctgctcgg ggacccccag tgcgacggct tccagaacaa gaagtgggac ctgttcgtgg     2340

agcggagcaa ggcctactcc aactgctacc cctacgacgt gccggactac gcgagcctgc     2400

gctccctcgt cgccagctcc ggcacgctgg agttcaacaa cgagagcttc aactggaccg     2460

gggtgaccca gaacggcacc tccagctcct gcatccgggg gagcaacaac tccttcttca     2520

gccgcctgaa ctggctcacg cacctgaagt tcaagtaccc cgccctgaac gtgaccatgc     2580

ccaacaacga gaagttcgac aagctctaca tctggggcgt ccaccacccc gggaccgaca     2640

acgaccagat cttcccgtac gcccaggcgt ccggccggat caccgtgagc acgaagcgca     2700

gccagcagac cgtgatcccc aacatcggct cccggccccg cgtccggaac atccccagcc     2760

gcatctccat ctactggacc atcgtgaagc cgggggacat cctgctgatc aacagcaccg     2820

gcaacctcat cgccccgcgg gggtacttca agatccgctc cggcaagagc tccatcatgc     2880

ggagcgacgc ccccatcggc aagtgcaact ccgagtgcat cacgcccaac gggagcatcc     2940

cgaacgacaa gcccttccag aacgtgaacc gcatcaccta cggcgcctgc ccccggtacg     3000

tcaagcagaa caccctgaag ctggccaccg ggatgcgcaa cgtgcccgag aagcagacgc     3060

ggggcatctt cggggcgatc gccggcttca tcgagaacgg ctgggagggg atggtggacg     3120

gctggtacgg gttccgccac cagaactccg agggcatcgg gcaggccgcc gacctcaaga     3180

gcacccaggc cgcgatcgac cagatcaacg gcaagctgaa ccggctgatc ggcaagacca     3240

acgagaagtt ccaccagatc gagaaggagt tctccgaggt cgaggggcgc atccaggacc     3300

tcgagaagta cgtggaggac accaagatcg acctgtggag ctacaacgcc gagctgctcg     3360

tggccctgga gaaccagcac acgatcgacc tgaccgactc cgagatgaac aagctcttcg     3420

agaagaccaa gaagcagctg cgggagaacg ccgaggacat gggcaacggg tgcttcaaga     3480

tctaccacaa gtgcgacaac gcctgcatcg gcagcatccg caacgggacc tacgaccacg     3540

acgtctaccg ggacgaggcg ctgaacaacc ggttccagat caagggcgtg gagctcaagt     3600

ccggctacaa ggactggatc ctgtggatca gcttcgccat ctcctgcttc ctgctctgcg     3660

tggccctgct ggggttcatc atgtgggcct gccagaaggg caacatccgc tgcaacatct     3720

gcatctgagg actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


<210>  23
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  23
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aagaccatca     2040

tcgccctgag ctacatcttc tgcctcgccc tgggccagga cctgcccggg aacgacaact     2100

ccaccgcgac gctctgcctg ggccaccacg ccgtgccgaa cgggaccctg gtcaagacca     2160

tcaccgacga ccagatcgag gtgacgaacg ccaccgagct cgtgcagagc tccagcaccg     2220

gcaagatctg caacaacccc caccggatcc tggacgggat cgactgcacc ctgatcgacg     2280

ccctcctggg cgacccccac tgcgacgtct tccagaacga gacgtgggac ctgttcgtgg     2340

agcgctccaa ggccttcagc aactgctacc cctacgacgt gccggactac gcgtccctcc     2400

ggagcctggt cgcctccagc ggcaccctgg agttcatcac cgaggggttc acctggacgg     2460

gcgtgaccca gaacgggggc tccaacgcct gcaagcgcgg gcccggcagc ggcttcttct     2520

cccggctcaa ctggctgacc aagagcgggt ccacctaccc cgtgctgaac gtcacgatgc     2580

ccaacaacga caacttcgac aagctctaca tctggggcgt gcaccacccg agcaccaacc     2640

aggagcagac ctccctgtac gtgcaggcca gcgggcgcgt caccgtgtcc acgcggcgca     2700

gccagcagac catcatcccc aacatcgaga gccggccctg ggtgcgcggc cagtccagcc     2760

ggatctccat ctactggacc atcgtcaagc ccggcgacgt gctggtgatc aacagcaacg     2820

ggaacctcat cgcgccgcgc ggctacttca agatgcggac cgggaagtcc agcatcatgc     2880

gctccgacgc ccccatcgac acgtgcatca gcgagtgcat cacccccaac ggctccatcc     2940

ccaacgacaa gccgttccag aacgtcaaca agatcaccta cggggcctgc cccaagtacg     3000

tgaagcagaa caccctgaag ctggccacgg gcatgcggaa cgtgcccgag aagcagaccc     3060

gcggcctctt cggggccatc gcgggcttca tcgagaacgg gtgggagggc atgatcgacg     3120

ggtggtacgg cttccggcac cagaacagcg agggcaccgg gcaggccgcc gacctgaagt     3180

ccacccaggc cgccatcgac cagatcaacg gcaaggtcaa ccgcatcatc gagaagacga     3240

acgagaagtt ccaccagatc gagaaggagt tcagcgaggt ggaggggcgg atccaggacc     3300

tggagaagta cgtggaggac accaagatcg acctctggtc ctacaacgcg gagctgctgg     3360

tcgccctcga gaaccagcac accatcgacc tgaccgacag cgagatgaac aagctgttcg     3420

agaagacgcg ccggcagctc cgcgagaacg ccgaggacat gggcaacggg tgcttcaaga     3480

tctaccacaa gtgcgacaac gcctgcatcg agtccatccg gagcggcacc tacgaccacg     3540

acgtgtaccg ggacgaggcc ctgaacaacc gcttccagat caagggcgtc gagctgaagt     3600

ccgggtacaa ggactggatc ctctggatca gcttcgcgat ctcctgcttc ctgctgtgcg     3660

tggtgctcct gggcttcatc atgtgggcct gccagcgggg gaacatccgc tgcaacatct     3720

gcatctgagg actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


<210>  24
<211>  3943
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  24
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg gccatcatct     2040

acctgatcct cctgttcacc gccgtgcggg gcgaccagat ctgcatcggg taccacgcga     2100

acaacagcac cgagaaggtc gacacgatcc tggagcgcaa cgtgaccgtg acccacgcca     2160

aggacatcct cgagaagacc cacaacggca agctgtgcaa gctgaacggg atcccgccgc     2220

tcgagctggg cgactgctcc atcgccgggt ggctgctcgg caaccccgag tgcgaccggc     2280

tgctgagcgt ccccgagtgg tcctacatca tggagaagga gaacccccgc gacggcctct     2340

gctacccggg gagcttcaac gactacgagg agctgaagca cctgctctcc agcgtgaagc     2400

acttcgagaa ggtgaagatc ctgcccaagg accggtggac gcagcacacc accaccggcg     2460

ggtcccgcgc ctgcgccgtc agcggcaacc cctccttctt ccggaacatg gtgtggctga     2520

cggagaaggg gagcaactac cccgtggcga agggctccta caacaacacc agcggcgagc     2580

agatgctcat catctggggc gtccaccacc cgaacgacga gaccgagcag cgcaccctgt     2640

accagaacgt ggggacgtac gtgtccgtcg ggaccagcac cctgaacaag cggtccaccc     2700

ccgagatcgc cacgcgcccc aaggtgaacg gccagggcgg gcggatggag ttcagctgga     2760

ccctcctgga catgtgggac accatcaact tcgagtccac cggcaacctg atcgcccccg     2820

agtacgggtt caagatcagc aagcgcggct ccagcgggat catgaagacg gagggcaccc     2880

tcgagaactg cgagaccaag tgccagaccc cgctgggcgc catcaacacg accctgccct     2940

tccacaacgt gcaccccctc accatcgggg agtgccccaa gtacgtcaag agcgagaagc     3000

tggtgctggc gaccggcctc cggaacgtgc cgcagatcga gtcccgcggg ctgttcggcg     3060

ccatcgccgg gttcatcgag ggcggctggc aggggatggt cgacggctgg tacgggtacc     3120

accacagcaa cgaccagggc tccgggtacg ccgccgacaa ggagagcacg cagaaggcgt     3180

tcgacggcat caccaacaag gtgaactccg tgatcgagaa gatgaacacc cagttcgagg     3240

ccgtcggcaa ggagttcagc aacctggagc ggcgcctcga gaacctgaac aagaagatgg     3300

aggacgggtt cctggacgtg tggacctaca acgccgagct cctggtgctg atggagaacg     3360

agcggacgct cgacttccac gactccaacg tcaagaacct gtacgacaag gtgcgcatgc     3420

agctgcggga caacgtcaag gagctcggca acgggtgctt cgagttctac cacaagtgcg     3480

acgacgagtg catgaacagc gtgaagaacg gcacctacga ctaccccaag tacgaggagg     3540

agtccaagct gaaccgcaac gagatcaagg gcgtgaagct gagctccatg ggggtctacc     3600

agatcctcgc catctacgcc accgtggcgg gcagcctgtc cctggccatc atgatggccg     3660

ggatcagctt ctggatgtgc tccaacggca gcctgcagtg ccggatctgc atctgaggac     3720

tagttataag actgactagc ccgatgggcc tcccaacggg ccctcctccc ctccttgcac     3780

cgagattaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaatgcatc cccccccccc cccccccccc cccccccccc aaaggctctt     3900

ttcagagcca ccagaattcg gatactctag acatatgctt aag                       3943


<210>  25
<211>  3946
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  25
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aacacccaga     2040

tcctggtgtt cgccctcgtc gccgtgatcc acaccaacgc ggacaagatc tgcctgggcc     2100

accacgccgt gagcaacggg acgaaggtca acaccctgac cgagcggggc gtggaggtgg     2160

tcaacgccac cgagacggtg gagcgcacca acatccccaa gatctgctcc aaggggaagc     2220

ggaccgtgga cctcggccag tgcgggctgc tgggcaccat cacgggccag ccgcagtgcg     2280

accagttcct cgagttcagc gccgacctga tcatcgagcg ccgggacggg aacgacgtct     2340

gctaccccgg caagttcgtg aacggggagg ccctgcgcca gatcctccgg aagtccggcg     2400

ggatcaacaa ggagaccatg ggcttcacct acagcggcat ccgcaccaac gggacgacct     2460

ccgcgtgccg gcgcagcggc tccagcttct acgccgagat gaagtggctg ctgtccgaca     2520

ccgacaacgc cgccttcccc cagatgacca agagctacaa gaacacgcgg cgcgagcccg     2580

cgctcatcgt gtgggggatc caccactccg gcagcaccac cgagcagacc aagctgtacg     2640

gctccgggaa caagctggtc acggtgggca gctccaagta ccagcagagc ttcgtgccgt     2700

cccccgagac ccggccccag gtcaacgggc agagcggccg catcgacttc cactggctca     2760

tcctggactc caacgacacc gtgaccttca gcttcaacgg ggccttcatc gcccccgacc     2820

gggccagctt cctgaagggc aagtccatgg gcatccagag cgacgtgcag gtcgacgcca     2880

actgcgaggg ggagtgctac cactccggcg ggacgatcac cagctccctc ccgttccaga     2940

acatcaacag ccgcgcggtg ggcaagtgcc cccggtacgt gaagcaggag tccctgctgc     3000

tcgccaccgg gatgaagaac gtccccgagc tgagcaagaa gcgccggaag cgcggcctgt     3060

tcggcgccat cgccgggttc atcgagaacg gctgggaggg gctcgtggac ggctggtacg     3120

ggttccggca ccagaacgcc cagggcgagg gcaccgcggc cgactacaag tccacgcaga     3180

gcgccatcga ccagatcacc gggaagctga accgcctgat cgagaagacc aaccagcagt     3240

tcgagctcat cgacaacgag ttcaccgagg tggagaagca gatcggcaac gtcatcaact     3300

ggacgcggga ctccatcacc gaggtgtgga gctacaacgc cgagctgctg gtcgccatgg     3360

agaaccagca caccatcgac ctcgcggact ccgagatgaa caagctgtac gagcgggtgc     3420

gcaagcagct gcgggagaac gccgaggagg acgggaccgg ctgcttcgag atcttccaca     3480

agtgcgacga cgactgcatg gccagcatcc gcaacaacac gtacgaccac tccaagtacc     3540

gggaggaggc catgcagaac cgcatccaga tcgaccccgt gaagctcagc ggcgggtaca     3600

aggacgtcat cctgtggttc tccttcggcg ccagctgctt cctgctcctg gcgatcgcca     3660

tggggctggt gttcatctgc gtgaagaacg gcaacatgcg gtgcaccatc tgcatctgac     3720

cactagttat aagactgact agcccgatgg gcctcccaac gggccctcct cccctccttg     3780

caccgagatt aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaatgc atcccccccc cccccccccc cccccccccc cccaaaggct     3900

cttttcagag ccaccagaat tcggatactc tagacatatg cttaag                    3946


<210>  26
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  26
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccatcc     2040

tggtggtcct cctgtacacc ttcgccaccg cgaacgccga cacgctgtgc atcggctacc     2100

acgccaacaa cagcaccgac accgtggaca ccgtgctcga gaagaacgtc acggtgaccc     2160

actccgtgaa cctgctggag gacaagcaca acgggaagct ctgcaagctg cggggcgtcg     2220

ccccgctgca cctcgggaag tgcaacatcg ccggctggat cctggggaac ccggagtgcg     2280

agagcctgtc caccgcgagc tcctggagct acatcgtgga gacctcctcc agcgacaacg     2340

gcacgtgcta ccccggcgac ttcatcgact acgaggagct ccgcgagcag ctgtccagcg     2400

tgtccagctt cgagcggttc gagatcttcc ccaagacctc cagctggccg aaccacgact     2460

ccaacaaggg ggtcaccgcc gcctgccccc acgccggcgc gaagagcttc tacaagaacc     2520

tgatctggct cgtgaagaag gggaactcct accccaagct gagcaagtcc tacatcaacg     2580

acaagggcaa ggaggtgctg gtcctctggg ggatccacca ccccagcacc agcgccgacc     2640

agcagtccct gtaccagaac gccgacgcct acgtgttcgt gggcagctcc cgctacagca     2700

agaagttcaa gccggagatc gccatccggc ccaaggtccg cgaccaggag ggccgcatga     2760

actactactg gaccctggtg gagcccgggg acaagatcac cttcgaggcg accggcaacc     2820

tcgtggtccc ccggtacgcc ttcgccatgg agcgcaacgc cgggtccggc atcatcatca     2880

gcgacacgcc ggtgcacgac tgcaacacca cctgccagac ccccaagggc gccatcaaca     2940

cgtccctgcc cttccagaac atccacccca tcaccatcgg gaagtgcccg aagtacgtga     3000

agagcaccaa gctgcggctc gcgaccggcc tgcgcaacgt cccctccatc cagagccggg     3060

ggctgttcgg cgccatcgcc gggttcatcg agggcggctg gacggggatg gtcgacggct     3120

ggtacgggta ccaccaccag aacgagcagg gcagcgggta cgccgccgac ctcaagtcca     3180

cgcagaacgc gatcgacgag atcaccaaca aggtgaacag cgtcatcgag aagatgaaca     3240

cccagttcac cgccgtgggc aaggagttca accacctgga gaagcggatc gagaacctga     3300

acaagaaggt cgacgacggc ttcctcgaca tctggacgta caacgccgag ctgctggtgc     3360

tcctggagaa cgagcgcacc ctggactacc acgactccaa cgtgaagaac ctctacgaga     3420

aggtccggag ccagctgaag aacaacgcca aggagatcgg gaacggctgc ttcgagttct     3480

accacaagtg cgacaacacc tgcatggagt ccgtgaagaa cgggacctac gactacccca     3540

agtacagcga ggaggccaag ctgaaccgcg aggagatcga cggcgtgaag ctcgagtcca     3600

cgcggatcta ccagatcctg gcgatctaca gcaccgtcgc cagctccctg gtgctcgtgg     3660

tcagcctggg ggccatctcc ttctggatgt gcagcaacgg ctccctgcag tgccgcatct     3720

gcatctgacc actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


<210>  27
<211>  4012
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  27
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccatca     2040

tcgtgctgct catggtcgtg accagcaacg ccgaccggat ctgcaccggc atcacgtcca     2100

gcaactcccc gcacgtggtc aagaccgcga cccaggggga ggtgaacgtg accggcgtca     2160

tcccgctgac gaccaccccc accaagagcc acttcgccaa cctgaagggg acggagaccc     2220

gcggcaagct ctgccccaag tgcctgaact gcaccgacct ggacgtggcc ctcgggcggc     2280

ccaagtgcac cggcaagatc ccgtccgccc gcgtgagcat cctgcacgag gtccggcccg     2340

tgacgtccgg ctgcttcccc atcatgcacg accgcaccaa gatccggcag ctgcccaacc     2400

tcctgcgcgg gtacgagcac atccggctga gcacccacaa cgtgatcaac gccgagaacg     2460

cgccgggcgg gccctacaag atcggcacct ccgggagctg ccccaacatc acgaacggca     2520

acggcttctt cgccaccatg gcctgggccg tccccaagaa cgacaagaac aagaccgcga     2580

ccaacccgct cacgatcgag gtgccctaca tctgcaccga gggggaggac cagatcaccg     2640

tgtggggctt ccactccgac aacgagaccc agatggccaa gctgtacggg gacagcaagc     2700

cccagaagtt cacgtccagc gccaacggcg tcaccaccca ctacgtgtcc cagatcggcg     2760

ggttccccaa ccagaccgag gacggcgggc tgccgcagag cggccgcatc gtggtcgact     2820

acatggtgca gaagtccggg aagacgggca ccatcaccta ccagcggggc atcctcctgc     2880

cccagaaggt gtggtgcgcc agcgggcgct ccaaggtcat caagggcagc ctgcccctca     2940

tcggggaggc cgactgcctg cacgagaagt acggcgggct gaacaagagc aagccctact     3000

acaccggcga gcacgcgaag gccatcggca actgcccgat ctgggtgaag acgcccctca     3060

agctggccaa cgggaccaag taccggcccc ccgccaagct gctcaaggag cgcggcttct     3120

tcggggccat cgcgggcttc ctggagggcg ggtgggaggg catgatcgcc gggtggcacg     3180

gctacacctc ccacggggcc cacggcgtgg ccgtcgccgc ggacctgaag agcacccagg     3240

aggccatcaa caagatcacg aagaacctca actccctgag cgagctggag gtgaagaacc     3300

tccagcggct gtccggcgcc atggacgagc tgcacaacga gatcctcgag ctggacgaga     3360

aggtcgacga cctgcgcgcc gacaccatca gctcccagat cgagctcgcc gtgctgctga     3420

gcaacgaggg gatcatcaac tccgaggacg agcacctcct ggcgctggag cggaagctca     3480

agaagatgct gggcccgagc gccgtggaga tcgggaacgg ctgcttcgag accaagcaca     3540

agtgcaacca gacctgcctg gaccgcatcg ccgccgggac cttcgacgcg ggcgagttct     3600

ccctccccac gttcgacagc ctgaacatca ccgccgcctc cctgaacgac gacggcctgg     3660

acaaccacac catcctcctg tactacagca ccgccgcctc cagcctggcg gtcacgctca     3720

tgatcgccat cttcgtggtg tacatggtct cccgggacaa cgtgagctgc tccatctgcc     3780

tgtgaggact agttataaga ctgactagcc cgatgggcct cccaacgggc cctcctcccc     3840

tccttgcacc gagattaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aaatgcatcc cccccccccc cccccccccc ccccccccca     3960

aaggctcttt tcagagccac cagaattcgg atactctaga catatgctta ag             4012


<210>  28
<211>  3955
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GC optimized HA construct

<400>  28
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct       60

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccacctg acgtctaata cgactcacta tagggagaaa gcttaccatg aaggccatcc     2040

tggtggtcct cctgtacacc ttcgccaccg cgaacgccga cacgctgtgc atcggctacc     2100

acgccaacaa cagcaccgac accgtggaca ccgtgctcga gaagaacgtc acggtgaccc     2160

actccgtgaa cctgctggag gacaagcaca acgggaagct ctgcaagctg cggggcgtcg     2220

ccccgctgca cctcgggaag tgcaacatcg ccggctggat cctggggaac ccggagtgcg     2280

agagcctgtc caccgcgagc tcctggagct acatcgtgga gacccccagc tccgacaacg     2340

gcacgtgcta ccccggcgac ttcatcgact acgaggagct ccgcgagcag ctgagctccg     2400

tgagctcctt cgagcggttc gagatcttcc ccaagaccag ctcctggccc aaccacgaca     2460

gcgacaaggg ggtcaccgcc gcctgcccgc acgccggcgc gaagtccttc tacaagaacc     2520

tgatctggct cgtgaagaag gggaacagct accccaagct gtccaagagc tacatcaacg     2580

acaagggcaa ggaggtgctg gtcctctggg ggatccacca ccccagcacc tccgccgacc     2640

agcagagcct gtaccagaac gccgacgcct acgtgttcgt gggctccagc cgctactcca     2700

agacgttcaa gcccgagatc gccatccggc cgaaggtccg cgaccgggag ggccggatga     2760

actactactg gacgctggtg gagcccgggg acaagatcac cttcgaggcg accggcaacc     2820

tcgtggtccc ccgctacgcc ttcgccatgg agcggaacgc cgggagcggc atcatcatct     2880

ccgacacccc cgtgcacgac tgcaacacga cctgccagac cccgaagggc gccatcaaca     2940

ccagcctgcc cttccagaac atccacccca tcacgatcgg gaagtgcccc aagtacgtga     3000

agtccaccaa gctgcgcctc gcgaccggcc tgcggaacat cccgagcatc cagtcccgcg     3060

ggctgttcgg cgccatcgcc gggttcatcg agggcggctg gaccgggatg gtggacggct     3120

ggtacgggta ccaccaccag aacgagcagg gcagcgggta cgccgccgac ctcaagtcca     3180

cgcagaacgc gatcgacgag atcaccaaca aggtgaacag cgtcatcgag aagatgaaca     3240

cccagttcac cgccgtgggc aaggagttca accacctgga gaagcggatc gagaacctga     3300

acaagaaggt cgacgacggc ttcctcgaca tctggacgta caacgccgag ctgctggtgc     3360

tcctggagaa cgagcgcacc ctggactacc acgactccaa cgtgaagaac ctctacgaga     3420

aggtccggag ccagctgaag aacaacgcca aggagatcgg gaacggctgc ttcgagttct     3480

accacaagtg cgacaacacc tgcatggagt ccgtgaagaa cgggacctac gactacccca     3540

agtacagcga ggaggccaag ctgaaccgcg aggagatcga cggcgtgaag ctcgagtcca     3600

cgcggatcta ccagatcctg gcgatctaca gcaccgtcgc cagctccctg gtgctcgtgg     3660

tcagcctggg ggccatctcc ttctggatgt gcagcaacgg ctccctgcag tgccgcatct     3720

gcatctgacc actagttata agactgacta gcccgatggg cctcccaacg ggccctcctc     3780

ccctccttgc accgagatta ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaatgca tccccccccc cccccccccc cccccccccc     3900

ccaaaggctc ttttcagagc caccagaatt cggatactct agacatatgc ttaag          3955


