                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  Stapled peptide inhibitors of NEMO as potential anti-inflammatory and 
       anti-cancer drugs

<130>  F226EP212

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  1

Leu Lys Ala Gln Ala Asp Ile Tyr Lys Ala Arg Phe Gln Ala Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20      


<210>  2
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Alanine or a cross-linked amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa (6) is Aspartic acid, a cross-linked or neutral amino acid
       Xaa (7) is Isoleucine or a cross-linked amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Alanine or a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  Xaa (13) is Glutamine  or a cross-linked amino acid
       Xaa (14) is Alanine  or a cross-linked amino acid
       Xaa (15) is Glutamic acid, a neutral amino acid or a basic amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is Histidine or Glutamine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is Glutamic acid, a neutral amino acid or a basic amino acid

<400>  2

Leu Lys Xaa Gln Ala Xaa Xaa Tyr Lys Xaa Arg Phe Xaa Xaa Xaa Arg 
1               5                   10                  15      


Xaa Ala Arg Xaa Lys 
            20      


<210>  3
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  3

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is a cross-linked amino acid 

<400>  4

Leu Lys Xaa Gln Ala Asp Xaa Tyr Lys Ala Arg Phe Gln Ala Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20      


<210>  5
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is a cross-linked amino acid 

<400>  5

Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Xaa Arg Phe Gln Ala Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20      



<210>  6
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is a cross-linked amino acid 

<400>  6

Leu Lys Ala Gln Ala Asp Ile Tyr Lys Xaa Arg Phe Gln Xaa Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20        


<210>  7
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is a cross-linked amino acid 

<400>  7

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Ala Gln Ala Asp Ile Tyr Lys Xaa Arg Phe Gln Xaa Glu Arg 
            20                  25                  30          


His Ala Arg Glu Lys 
        35          


<210>  8
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is a cross-linked amino acid 

<400>  8

Leu Lys Xaa Gln Ala Asp Ile Tyr Lys Xaa Arg Phe Gln Ala Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20      


<210>  9
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is a cross-linked amino acid 

<400>  9

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Xaa Gln Ala Asp Ile Tyr Lys Xaa Arg Phe Gln Ala Glu Arg 
            20                  25                  30          


His Ala Arg Glu Lys 
        35          


<210>  10
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is a cross-linked amino acid 

<400>  10

Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Glu Arg 
1               5                   10                  15      


His Ala Arg Glu Lys 
            20      


<210>  11
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is a cross-linked amino acid 

<400>  11

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Glu Arg 
            20                  25                  30          


His Ala Arg Glu Lys 
        35          


<210>  12
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is a cross-linked amino acid 

<400>  12

Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Gln Arg 
1               5                   10                  15      


His Ala Arg Gln Lys 
            20      


<210>  13
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is a cross-linked amino acid 

<400>  13

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Gln Arg 
            20                  25                  30          


His Ala Arg Gln Lys 
        35          


<210>  14
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is a cross-linked amino acid 

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is Glutamic acid methyl ester

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is Glutamic acid methyl ester

<400>  14

Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Xaa Arg 
1               5                   10                  15      


His Ala Arg Xaa Lys 
            20      


<210>  15
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is is a cross-linked amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is is a cross-linked amino acidr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Glutamic acid methyl ester

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa is Glutamic acid methyl ester

<400>  15

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Ala Gln Ala Xaa Ile Tyr Lys Ala Arg Phe Xaa Ala Xaa Arg 
            20                  25                  30          


His Ala Arg Xaa Lys 
        35          


<210>  16
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  16

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Ala Gln Ala Asp Ile Tyr Lys Ala Arg Phe Gln Ala Glu Arg 
            20                  25                  30          


His Ala Arg Glu Lys 
        35          


210>  17
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)


<400>  17

Leu Lys Xaa Gln Xaa Asp Ile Tyr Lys Xaa Arg Phe Gln Xaa Glu Arg 
1               5                   10                  15      


His Xaa Arg Glu Lys 
            20      


<210>  18
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa is 2-Aminoisobutyric acid (Aib)

<400>  18

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Leu Lys Xaa Gln Xaa Asp Ile Tyr Lys Xaa Arg Phe Gln Xaa Glu Arg 
            20                  25                  30          


His Xaa Arg Glu Lys 
        35          
    


<210>  19
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is is a cross-linked amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is is a cross-linked amino acid

<400>  19

Glu Leu Ala Gln Leu Gln Ala Glu Leu Asp Xaa Val Gln Ala Val Val 
1               5                   10                  15      


Gln Xaa Asp Lys Gln Glu Leu Arg Lys Leu 
            20                  25      


