               SEQUENCE LISTING

<110> Venter Pharma

<120> ENZYMATIC METHOD FOR THE EVALUATION OF XYLOSE

<130> PCT-07448

<150> PCT/US62/270825
<151> 0028-06-06

<160> 8

<170> BiSSAP 1.3.6

<210> 1
<211> 660
<212> DNA
<213> Caulobacter crescentus NA1000


<220> 
<223> xylB

<400> 1
atgtcctcag ccatctatcc cagcctgaag ggcaagcgcg tcgtcatcac cggcggcggc      60

tcgggcatcg gggccggcct caccgccggc ttcgcccgtc agggcgcgga ggtgatcttc     120

ctcgacatcg ccgacgagga ctccagggct cttgaggccg agctggccgg ctcgccgatc     180

ccgccggtct acaagcgctg cgacctgatg aacctcgagg cgatcaaggc ggtcttcgcc     240

gagatcggcg acgtcgacgt gctggtcaac aacgccggca atgacgaccg ccacaagctg     300

gccgacgtga ccggcgccta ttgggacgag cggatcaacg tcaacctgcg ccacatgctg     360

ttctgcaccc aggccgtcgc gccgggcatg aagaagcgtg gcggcggggc ggtgatcaac     420

ttcggttcga tcagctggca cctggggctt gaggacctcg tcctctacga aaccgccaag     480

gccggcatcg aaggcatgac ccgcgcgctg gcccgggagc tgggtcccga cgacatccgc     540

gtcacctgcg tggtgccggg caacgtcaag accaagcgcc aggagaagtg gtacacgccc     600

gaaggcgagg cccagatcgt ggcggcccaa tgcctgaagg gccgcatcgt cccggagaac     660


<210> 2
<211> 248
<212> PRT
<213> Caulobacter crescentus NA1000


<220> 
<223> Xylose dehydrogenase XylB

<400> 2
Met Ser Ser Ala Ile Tyr Pro Ser Leu Lys Gly Lys Arg Val Val Ile 
1               5                   10                  15      
Thr Gly Gly Gly Ser Gly Ile Gly Ala Gly Leu Thr Ala Gly Phe Ala 
            20                  25                  30          
Arg Gln Gly Ala Glu Val Ile Phe Leu Asp Ile Ala Asp Glu Asp Ser 
        35                  40                  45              
Arg Ala Leu Glu Ala Glu Leu Ala Gly Ser Pro Ile Pro Pro Val Tyr 
    50                  55                  60                  
Lys Arg Cys Asp Leu Met Asn Leu Glu Ala Ile Lys Ala Val Phe Ala 
65                  70                  75                  80  
Glu Ile Gly Asp Val Asp Val Leu Val Asn Asn Ala Gly Asn Asp Asp 
                85                  90                  95      
Arg His Lys Leu Ala Asp Val Thr Gly Ala Tyr Trp Asp Glu Arg Ile 
            100                 105                 110         
Asn Val Asn Leu Arg His Met Leu Phe Cys Thr Gln Ala Val Ala Pro 
        115                 120                 125             
Gly Met Lys Lys Arg Gly Gly Gly Ala Val Ile Asn Phe Gly Ser Ile 
    130                 135                 140                 
Ser Trp His Leu Gly Leu Glu Asp Leu Val Leu Tyr Glu Thr Ala Lys 
145                 150                 155                 160 
Ala Gly Ile Glu Gly Met Thr Arg Ala Leu Ala Arg Glu Leu Gly Pro 
                165                 170                 175     
Asp Asp Ile Arg Val Thr Cys Val Val Pro Gly Asn Val Lys Thr Lys 
            180                 185                 190         
Arg Gln Glu Lys Trp Tyr Thr Pro Glu Gly Glu Ala Gln Ile Val Ala 
        195                 200                 205             
Ala Gln Cys Leu Lys Gly Arg Ile Val Pro Glu Asn Val Ala Ala Leu 
    210                 215                 220                 
Val Leu Phe Leu Ala Ser Asp Asp Ala Ser Leu Cys Thr Gly His Glu 
225                 230                 235                 240 
Tyr Trp Ile Asp Ala Gly Trp Arg 
                245             

<210> 3
<211> 747
<212> DNA
<213> Artificial Sequence


<220> 
<223> Gene xylB from C. crescentus strain NA1000 codon optimized

<400> 3
atgtcctctg cgatttatcc gagtctgaaa ggcaaacgtg tggtgattac gggtggtggt      60

tctggtattg gtgctggtct gacggcgggt tttgcgcgtc agggtgccga agtgattttc     120

ctggatatcg cggatgaaga cagtcgcgca ctggaagctg aactggcagg tagcccgatt     180

ccgccggtct ataaacgttg cgatctgatg aacctggaag ccattaaagc agtttttgct     240

gaaatcggtg atgtcgacgt gctggttaac aatgcaggca atgatgaccg ccataaactg     300

gcagatgtta ccggtgctta ctgggacgaa cgtatcaacg tcaatctgcg ccacatgctg     360

ttttgtacgc aggcggtggc cccgggcatg aaaaaacgtg gcggtggcgc cgttattaac     420

ttcggtagca tctcttggca tctgggcctg gaagatctgg tgctgtatga aaccgcaaaa     480

gctggtattg agggtatgac gcgtgcactg gcacgtgaac tgggtccgga tgacatccgt     540

gtcacctgcg tggttccggg caacgtgaaa accaaacgcc aagaaaaatg gtacacgccg     600

gaaggtgaag cccagattgt tgcggcccaa tgtctgaaag gccgcatcgt cccggaaaat     660

gtggcagctc tggttctgtt cctggcgtcg gatgatgcgt cgctgtgtac gggtcacgaa     720

tactggattg atgcgggctg gcgttga                                         747


<210> 4
<211> 764
<212> DNA
<213> Artificial Sequence


<220> 
<223> xylB synthetic gene, including restriction sites for the
      endonucleases NcoI, NdeI and HindIII

<400> 4
ccatgggcca tatgtcctct gcgatttatc cgagtctgaa aggcaaacgt gtggtgatta      60

cgggtggtgg ttctggtatt ggtgctggtc tgacggcggg ttttgcgcgt cagggtgccg     120

aagtgatttt cctggatatc gcggatgaag acagtcgcgc actggaagct gaactggcag     180

gtagcccgat tccgccggtc tataaacgtt gcgatctgat gaacctggaa gccattaaag     240

cagtttttgc tgaaatcggt gatgtcgacg tgctggttaa caatgcaggc aatgatgacc     300

gccataaact ggcagatgtt accggtgctt actgggacga acgtatcaac gtcaatctgc     360

gccacatgct gttttgtacg caggcggtgg ccccgggcat gaaaaaacgt ggcggtggcg     420

ccgttattaa cttcggtagc atctcttggc atctgggcct ggaagatctg gtgctgtatg     480

aaaccgcaaa agctggtatt gagggtatga cgcgtgcact ggcacgtgaa ctgggtccgg     540

atgacatccg tgtcacctgc gtggttccgg gcaacgtgaa aaccaaacgc caagaaaaat     600

ggtacacgcc ggaaggtgaa gcccagattg ttgcggccca atgtctgaaa ggccgcatcg     660

tcccggaaaa tgtggcagct ctggttctgt tcctggcgtc ggatgatgcg tcgctgtgta     720

cgggtcacga atactggatt gatgcgggct ggcgttgaaa gctt                      764


<210> 5
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of the protein XylB-wt

<400> 5
Met Gly His Met Ser Ser Ala Ile Tyr Pro Ser Leu Lys Gly Lys Arg 
1               5                   10                  15      
Val Val Ile Thr Gly Gly Gly Ser Gly Ile Gly Ala Gly Leu Thr Ala 
            20                  25                  30          
Gly Phe Ala Arg Gln Gly Ala Glu Val Ile Phe Leu Asp Ile Ala Asp 
        35                  40                  45              
Glu Asp Ser Arg Ala Leu Glu Ala Glu Leu Ala Gly Ser Pro Ile Pro 
    50                  55                  60                  
Pro Val Tyr Lys Arg Cys Asp Leu Met Asn Leu Glu Ala Ile Lys Ala 
65                  70                  75                  80  
Val Phe Ala Glu Ile Gly Asp Val Asp Val Leu Val Asn Asn Ala Gly 
                85                  90                  95      
Asn Asp Asp Arg His Lys Leu Ala Asp Val Thr Gly Ala Tyr Trp Asp 
            100                 105                 110         
Glu Arg Ile Asn Val Asn Leu Arg His Met Leu Phe Cys Thr Gln Ala 
        115                 120                 125             
Val Ala Pro Gly Met Lys Lys Arg Gly Gly Gly Ala Val Ile Asn Phe 
    130                 135                 140                 
Gly Ser Ile Ser Trp His Leu Gly Leu Glu Asp Leu Val Leu Tyr Glu 
145                 150                 155                 160 
Thr Ala Lys Ala Gly Ile Glu Gly Met Thr Arg Ala Leu Ala Arg Glu 
                165                 170                 175     
Leu Gly Pro Asp Asp Ile Arg Val Thr Cys Val Val Pro Gly Asn Val 
            180                 185                 190         
Lys Thr Lys Arg Gln Glu Lys Trp Tyr Thr Pro Glu Gly Glu Ala Gln 
        195                 200                 205             
Ile Val Ala Ala Gln Cys Leu Lys Gly Arg Ile Val Pro Glu Asn Val 
    210                 215                 220                 
Ala Ala Leu Val Leu Phe Leu Ala Ser Asp Asp Ala Ser Leu Cys Thr 
225                 230                 235                 240 
Gly His Glu Tyr Trp Ile Asp Ala Gly Trp Arg 
                245                 250     

<210> 6
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of the protein XylB-6His

<400> 6
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Ser Ser Ala Ile Tyr Pro Ser Leu Lys Gly Lys 
            20                  25                  30          
Arg Val Val Ile Thr Gly Gly Gly Ser Gly Ile Gly Ala Gly Leu Thr 
        35                  40                  45              
Ala Gly Phe Ala Arg Gln Gly Ala Glu Val Ile Phe Leu Asp Ile Ala 
    50                  55                  60                  
Asp Glu Asp Ser Arg Ala Leu Glu Ala Glu Leu Ala Gly Ser Pro Ile 
65                  70                  75                  80  
Pro Pro Val Tyr Lys Arg Cys Asp Leu Met Asn Leu Glu Ala Ile Lys 
                85                  90                  95      
Ala Val Phe Ala Glu Ile Gly Asp Val Asp Val Leu Val Asn Asn Ala 
            100                 105                 110         
Gly Asn Asp Asp Arg His Lys Leu Ala Asp Val Thr Gly Ala Tyr Trp 
        115                 120                 125             
Asp Glu Arg Ile Asn Val Asn Leu Arg His Met Leu Phe Cys Thr Gln 
    130                 135                 140                 
Ala Val Ala Pro Gly Met Lys Lys Arg Gly Gly Gly Ala Val Ile Asn 
145                 150                 155                 160 
Phe Gly Ser Ile Ser Trp His Leu Gly Leu Glu Asp Leu Val Leu Tyr 
                165                 170                 175     
Glu Thr Ala Lys Ala Gly Ile Glu Gly Met Thr Arg Ala Leu Ala Arg 
            180                 185                 190         
Glu Leu Gly Pro Asp Asp Ile Arg Val Thr Cys Val Val Pro Gly Asn 
        195                 200                 205             
Val Lys Thr Lys Arg Gln Glu Lys Trp Tyr Thr Pro Glu Gly Glu Ala 
    210                 215                 220                 
Gln Ile Val Ala Ala Gln Cys Leu Lys Gly Arg Ile Val Pro Glu Asn 
225                 230                 235                 240 
Val Ala Ala Leu Val Leu Phe Leu Ala Ser Asp Asp Ala Ser Leu Cys 
                245                 250                 255     
Thr Gly His Glu Tyr Trp Ile Asp Ala Gly Trp Arg 
            260                 265             

<210> 7
<211> 6004
<212> DNA
<213> Artificial Sequence


<220> 
<223> pET-xylB-wt

<400> 7
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggccata tgtcctctgc gatttatccg     5100

agtctgaaag gcaaacgtgt ggtgattacg ggtggtggtt ctggtattgg tgctggtctg     5160

acggcgggtt ttgcgcgtca gggtgccgaa gtgattttcc tggatatcgc ggatgaagac     5220

agtcgcgcac tggaagctga actggcaggt agcccgattc cgccggtcta taaacgttgc     5280

gatctgatga acctggaagc cattaaagca gtttttgctg aaatcggtga tgtcgacgtg     5340

ctggttaaca atgcaggcaa tgatgaccgc cataaactgg cagatgttac cggtgcttac     5400

tgggacgaac gtatcaacgt caatctgcgc cacatgctgt tttgtacgca ggcggtggcc     5460

ccgggcatga aaaaacgtgg cggtggcgcc gttattaact tcggtagcat ctcttggcat     5520

ctgggcctgg aagatctggt gctgtatgaa accgcaaaag ctggtattga gggtatgacg     5580

cgtgcactgg cacgtgaact gggtccggat gacatccgtg tcacctgcgt ggttccgggc     5640

aacgtgaaaa ccaaacgcca agaaaaatgg tacacgccgg aaggtgaagc ccagattgtt     5700

gcggcccaat gtctgaaagg ccgcatcgtc ccggaaaatg tggcagctct ggttctgttc     5760

ctggcgtcgg atgatgcgtc gctgtgtacg ggtcacgaat actggattga tgcgggctgg     5820

cgttgaaagc ttgcggccgc actcgagcac caccaccacc accactgaga tccggctgct     5880

aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actagcataa     5940

ccccttgggg cctctaaacg ggtcttgagg ggttttttgc tgaaaggagg aactatatcc     6000

ggat                                                                  6004


<210> 8
<211> 6055
<212> DNA
<213> Artificial Sequence


<220> 
<223> Plasmid pET-xylB-6His

<400> 8
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac     5100

agcagcggcc tggtgccgcg cggcagccat atgtcctctg cgatttatcc gagtctgaaa     5160

ggcaaacgtg tggtgattac gggtggtggt tctggtattg gtgctggtct gacggcgggt     5220

tttgcgcgtc agggtgccga agtgattttc ctggatatcg cggatgaaga cagtcgcgca     5280

ctggaagctg aactggcagg tagcccgatt ccgccggtct ataaacgttg cgatctgatg     5340

aacctggaag ccattaaagc agtttttgct gaaatcggtg atgtcgacgt gctggttaac     5400

aatgcaggca atgatgaccg ccataaactg gcagatgtta ccggtgctta ctgggacgaa     5460

cgtatcaacg tcaatctgcg ccacatgctg ttttgtacgc aggcggtggc cccgggcatg     5520

aaaaaacgtg gcggtggcgc cgttattaac ttcggtagca tctcttggca tctgggcctg     5580

gaagatctgg tgctgtatga aaccgcaaaa gctggtattg agggtatgac gcgtgcactg     5640

gcacgtgaac tgggtccgga tgacatccgt gtcacctgcg tggttccggg caacgtgaaa     5700

accaaacgcc aagaaaaatg gtacacgccg gaaggtgaag cccagattgt tgcggcccaa     5760

tgtctgaaag gccgcatcgt cccggaaaat gtggcagctc tggttctgtt cctggcgtcg     5820

gatgatgcgt cgctgtgtac gggtcacgaa tactggattg atgcgggctg gcgttgaaag     5880

cttgcggccg cactcgagca ccaccaccac caccactgag atccggctgc taacaaagcc     5940

cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata accccttggg     6000

gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc cggat          6055


