                     б
   
   <110>  ھ׼ҽƿƼ޹˾
    
   <120>  IL-12ȶĤƼƷ;
   
   <130>  P2015-1150
   
   <160>  8     
   
   <170>  PatentIn version 3.5
   
   <210>  1
   <211>  2742
   <212>  DNA
   <213>  ˹
   
   <220>
   <221>  misc_feature
   <223>  IL-12/dKSCD62L
   
   <400>  1
   atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60
   gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120
   gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180
   accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240
   gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300
   ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360
   aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420
   acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480
   ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540
   agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600
   gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660
   gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720
   ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780
   acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840
   agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900
   cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960
   gaatgggcat ctgtgccctg cagtggtggc ggtggcggcg gatctagaaa cctccccgtg     1020
   gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc     1080
   gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa     1140
   gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca     1200
   ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat     1260
   gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt     1320
   tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg     1380
   gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg     1440
   caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat     1500
   ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat tcgggcagtg     1560
   actattgata gagtgatgag ctatctgaat gcttccgggt ctacatctgg atctgggaag     1620
   ccgggttctg gtgagggttc tatgggcata tttccatgga aatgtcagag cacccagagg     1680
   gacttatgga acatcttcaa gttgtggggg tggacaatgc tctgttgtga tttcctggca     1740
   catcatggaa ccgactgctg gacttaccat tattctgaaa aacccatgaa ctggcaaagg     1800
   gctagaagat tctgccgaga caattacaca gatttagttg ccatacaaaa caaggcggaa     1860
   attgagtatc tggagaagac tctgcctttc agtcgttctt actactggat aggaatccgg     1920
   aagataggag gaatatggac gtgggtggga accaacaaat ctcttactga agaagcagag     1980
   aactggggag atggtgagcc caacaacaag aagaacaagg aggactgcgt ggagatctat     2040
   atcaagagaa acaaagatgc aggcaaatgg aacgatgacg cctgccacaa actaaaggca     2100
   gccctctgtt acacagcttc ttgccagccc tggtcatgca gtggccatgg agaatgtgta     2160
   gaaatcatca ataattacac ctgcaactgt gatgtggggt actatgggcc ccagtgtcag     2220
   tttgtgattc agtgtgagcc tttggaggcc ccagagctgg gtaccatgga ctgtactcac     2280
   cctttgggaa acttcagctt cagctcacag tgtgccttca gctgctctga aggaacaaac     2340
   ttaactggga ttgaagaaac cacctgtgga ccatttggaa actggtcatc tccagaacca     2400
   acctgtcaag tgattcagtg tgagcctcta tcagcaccag atttggggat catgaactgt     2460
   agccatcccc tggccagctt cagctttacc tctgcatgta ccttcatctg ctcagaagga     2520
   actgagttaa ttgggaagaa gaaaaccatt tgtgaatcat ctggaatctg gtcaaatcct     2580
   agtccaatat gtcaaatgat taaggagggt gattataacc ccctcttcat tccagtggca     2640
   gtcatggtta ctgcattctc tgggttggca tttatcattt ggctggcaag gagattaaaa     2700
   aaaggcaaga aatccaagag aagtatgaat gacccatatt aa                        2742
   
   <210>  2
   <211>  913
   <212>  PRT
   <213>  ˹
   
   <220>
   <221>  misc_feature
   <223>  IL-12/dKSCD62L
   
   <400>  2
   
   Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
   1               5                   10                  15      
   Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
               20                  25                  30          
   Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
           35                  40                  45              
   Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
       50                  55                  60                  
   Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
   65                  70                  75                  80  
   Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                   85                  90                  95      
   Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
               100                 105                 110         
   Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
           115                 120                 125             
   Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
       130                 135                 140                 
   Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
   145                 150                 155                 160 
   Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                   165                 170                 175     
   Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
               180                 185                 190         
   Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
           195                 200                 205             
   Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
       210                 215                 220                 
   Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
   225                 230                 235                 240 
   Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                   245                 250                 255     
   Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
               260                 265                 270         
   Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
           275                 280                 285             
   Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
       290                 295                 300                 
   Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
   305                 310                 315                 320 
   Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                   325                 330                 335     
   Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
               340                 345                 350         
   His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
           355                 360                 365             
   Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
       370                 375                 380                 
   Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
   385                 390                 395                 400 
   Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                   405                 410                 415     
   Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
               420                 425                 430         
   Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
           435                 440                 445             
   Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
       450                 455                 460                 
   Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
   465                 470                 475                 480 
   Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                   485                 490                 495     
   Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
               500                 505                 510         
   His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
           515                 520                 525             
   Leu Asn Ala Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
       530                 535                 540                 
   Glu Gly Ser Met Gly Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg 
   545                 550                 555                 560 
   Asp Leu Trp Asn Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys 
                   565                 570                 575     
   Asp Phe Leu Ala His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser 
               580                 585                 590         
   Glu Lys Pro Met Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn 
           595                 600                 605             
   Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu 
       610                 615                 620                 
   Glu Lys Thr Leu Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg 
   625                 630                 635                 640 
   Lys Ile Gly Gly Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr 
                   645                 650                 655     
   Glu Glu Ala Glu Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn 
               660                 665                 670         
   Lys Glu Asp Cys Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly 
           675                 680                 685             
   Lys Trp Asn Asp Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr 
       690                 695                 700                 
   Thr Ala Ser Cys Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val 
   705                 710                 715                 720 
   Glu Ile Ile Asn Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly 
                   725                 730                 735     
   Pro Gln Cys Gln Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu 
               740                 745                 750         
   Leu Gly Thr Met Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser 
           755                 760                 765             
   Ser Gln Cys Ala Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile 
       770                 775                 780                 
   Glu Glu Thr Thr Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro 
   785                 790                 795                 800 
   Thr Cys Gln Val Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly 
                   805                 810                 815     
   Ile Met Asn Cys Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala 
               820                 825                 830         
   Cys Thr Phe Ile Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys 
           835                 840                 845             
   Thr Ile Cys Glu Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys 
       850                 855                 860                 
   Gln Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala 
   865                 870                 875                 880 
   Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala 
                   885                 890                 895     
   Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro 
               900                 905                 910         
   Tyr 
       
   
   <210>  3
   <211>  1596
   <212>  DNA
   <213>  (Homo sapiens)
   
   <400>  3
   atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60
   gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120
   gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180
   accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240
   gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300
   ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360
   aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420
   acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480
   ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540
   agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600
   gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660
   gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720
   ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780
   acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840
   agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900
   cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960
   gaatgggcat ctgtgccctg cagtggtggc ggtggcggcg gatctagaaa cctccccgtg     1020
   gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc     1080
   gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa     1140
   gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca     1200
   ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat     1260
   gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt     1320
   tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg     1380
   gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg     1440
   caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat     1500
   ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat tcgggcagtg     1560
   actattgata gagtgatgag ctatctgaat gcttcc                               1596
   
   <210>  4
   <211>  532
   <212>  PRT
   <213>  (Homo sapiens)
   
   <400>  4
   Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
   1               5                   10                  15      
   Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
               20                  25                  30          
   Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
           35                  40                  45              
   Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
       50                  55                  60                  
   Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
   65                  70                  75                  80  
   Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                   85                  90                  95      
   Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
               100                 105                 110         
   Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
           115                 120                 125             
   Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
       130                 135                 140                 
   Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
   145                 150                 155                 160 
   Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                   165                 170                 175     
   Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
               180                 185                 190         
   Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
           195                 200                 205             
   Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
       210                 215                 220                 
   Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
   225                 230                 235                 240 
   Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                   245                 250                 255     
   Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
               260                 265                 270         
   Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
           275                 280                 285             
   Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
       290                 295                 300                 
   Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
   305                 310                 315                 320 
   Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                   325                 330                 335     
   Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
               340                 345                 350         
   His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
           355                 360                 365             
   Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
       370                 375                 380                 
   Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
   385                 390                 395                 400 
   Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                   405                 410                 415     
   Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
               420                 425                 430         
   Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
           435                 440                 445             
   Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
       450                 455                 460                 
   Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
   465                 470                 475                 480 
   Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                   485                 490                 495     
   Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
               500                 505                 510         
   His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
           515                 520                 525             
   Leu Asn Ala Ser 
       530         
   
   <210>  5
   <211>  1101
   <212>  DNA
   <213>  ˹
   
   <220>
   <221>  misc_feature
   <223>  dKSCD62L
   
   <400>  5
   atgggcatat ttccatggaa atgtcagagc acccagaggg acttatggaa catcttcaag       60
   ttgtgggggt ggacaatgct ctgttgtgat ttcctggcac atcatggaac cgactgctgg      120
   acttaccatt attctgaaaa acccatgaac tggcaaaggg ctagaagatt ctgccgagac      180
   aattacacag atttagttgc catacaaaac aaggcggaaa ttgagtatct ggagaagact      240
   ctgcctttca gtcgttctta ctactggata ggaatccgga agataggagg aatatggacg      300
   tgggtgggaa ccaacaaatc tcttactgaa gaagcagaga actggggaga tggtgagccc      360
   aacaacaaga agaacaagga ggactgcgtg gagatctata tcaagagaaa caaagatgca      420
   ggcaaatgga acgatgacgc ctgccacaaa ctaaaggcag ccctctgtta cacagcttct      480
   tgccagccct ggtcatgcag tggccatgga gaatgtgtag aaatcatcaa taattacacc      540
   tgcaactgtg atgtggggta ctatgggccc cagtgtcagt ttgtgattca gtgtgagcct      600
   ttggaggccc cagagctggg taccatggac tgtactcacc ctttgggaaa cttcagcttc      660
   agctcacagt gtgccttcag ctgctctgaa ggaacaaact taactgggat tgaagaaacc      720
   acctgtggac catttggaaa ctggtcatct ccagaaccaa cctgtcaagt gattcagtgt      780
   gagcctctat cagcaccaga tttggggatc atgaactgta gccatcccct ggccagcttc      840
   agctttacct ctgcatgtac cttcatctgc tcagaaggaa ctgagttaat tgggaagaag      900
   aaaaccattt gtgaatcatc tggaatctgg tcaaatccta gtccaatatg tcaaatgatt      960
   aaggagggtg attataaccc cctcttcatt ccagtggcag tcatggttac tgcattctct     1020
   gggttggcat ttatcatttg gctggcaagg agattaaaaa aaggcaagaa atccaagaga     1080
   agtatgaatg acccatatta a                                               1101
   
   <210>  6
   <211>  366
   <212>  PRT
   <213>  ˹
   
   <220>
   <221>  misc_feature
   <223>  dKSCD62L
   
   <400>  6
   Met Gly Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp 
   1               5                   10                  15      
   Asn Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu 
               20                  25                  30          
   Ala His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro 
           35                  40                  45              
   Met Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp 
       50                  55                  60                  
   Leu Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr 
   65                  70                  75                  80  
   Leu Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly 
                   85                  90                  95      
   Gly Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala 
               100                 105                 110         
   Glu Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp 
           115                 120                 125             
   Cys Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn 
       130                 135                 140                 
   Asp Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser 
   145                 150                 155                 160 
   Cys Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile 
                   165                 170                 175     
   Asn Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys 
               180                 185                 190         
   Gln Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr 
           195                 200                 205             
   Met Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys 
       210                 215                 220                 
   Ala Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr 
   225                 230                 235                 240 
   Thr Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln 
                   245                 250                 255     
   Val Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn 
               260                 265                 270         
   Cys Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe 
           275                 280                 285             
   Ile Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys 
       290                 295                 300                 
   Glu Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Met Ile 
   305                 310                 315                 320 
   Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala Val Met Val 
                   325                 330                 335     
   Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala Arg Arg Leu 
               340                 345                 350         
   Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro Tyr 
           355                 360                 365     
   
   <210>  7
   <211>  15
   <212>  PRT
   <213>  ˹
   
   <400>  7
   Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
   1               5                   10                  15  
   
   <210>  8
   <211>  7
   <212>  PRT
   <213>  ˹
   
   <400>  8
   Gly Gly Gly Gly Gly Gly Ser 
   1               5          
     

