                         SEQUENCE LISTING

<110>  La Jolla Institute for Allergy and Immunology
       Altman, Amnon
       Kong, Kok-Fai
       Crotty, Shane
 
<120>  Peptides and Methods Related to ICOS Signaling

<130>  2015-108-02

<150>  US 62/267,954
<151>  2015-12-16

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  2
<211>  199
<212>  PRT
<213>  Pan troglodytes

<400>  2

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Arg Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  3
<211>  199
<212>  PRT
<213>  Pongo Abelii

<400>  3

Met Lys Ser Arg Leu Trp Tyr Leu Phe Leu Phe Cys Leu His Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Arg Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Arg Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Lys Leu Thr Asp Val Thr Ile 
        195                 


<210>  4
<211>  199
<212>  PRT
<213>  Macaca mulatta

<400>  4

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu His Met Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Arg Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Thr Phe Val Val Val Cys Ile Phe Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Thr Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Val 
        195                 


<210>  5
<211>  208
<212>  PRT
<213>  Canis familiaris

<400>  5

Met Lys Ser Asp Leu Trp Tyr Phe Leu Leu Phe Cys Phe Gln Val Glu 
1               5                   10                  15      


Ala Leu Thr Gly Glu Ile Asn Asp Ser Thr Lys Ser Glu Met Phe Thr 
            20                  25                  30          


Phe His Asp Gly Gly Val Gln Ile Leu Cys Lys Phe Asn Ala Ile Val 
        35                  40                  45              


Ser Gln Tyr Lys Met Glu Leu Leu Lys Gly Thr Glu Val Leu Cys Asp 
    50                  55                  60                  


Leu Thr Thr Thr Lys Glu Asn Gly Asn Thr Val Ser Lys Asn Pro Lys 
65                  70                  75                  80  


Phe Cys Gln Ser Gln Ser Ser Ser Asp Gly Val Ser Phe Phe Leu Tyr 
                85                  90                  95      


Asn Leu Asp Ser Ser His Ala Ser Tyr Tyr Ala Cys Gln Leu Ser Ile 
            100                 105                 110         


Phe Asp Pro Pro Pro Phe Gln Arg Lys Asn Ile Ser Arg Glu Tyr Leu 
        115                 120                 125             


Asn Val Tyr Glu Ser Gln Thr Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Tyr Ile Phe Gly Cys Ile Phe 
145                 150                 155                 160 


Leu Cys Trp Leu Thr Lys Lys Lys Tyr Arg Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Ala Lys Lys Pro 
            180                 185                 190         


Gly Leu Thr Gly Val Thr His Asn Leu Glu Leu Cys Gly Thr Gln Ala 
        195                 200                 205             


<210>  6
<211>  180
<212>  PRT
<213>  Felis catus

<400>  6

Met Phe Thr Phe His Asp Gly Gly Ile Gln Ile Ser Cys Lys Phe Ser 
1               5                   10                  15      


Glu Ile Ala Leu Gln Phe Lys Met Lys Leu Leu Lys Gly Thr Glu Val 
            20                  25                  30          


Leu Cys Asp Leu Thr Lys Thr Lys Glu Ser Gly Asn Thr Val Ser Ile 
        35                  40                  45              


Lys Asn Leu Lys Phe Cys Gln Thr Gln Leu Phe Asn Asp Ser Val Ser 
    50                  55                  60                  


Phe Phe Leu Tyr Asn Leu Asp Ser Ser His Ala Ser Tyr Tyr Thr Cys 
65                  70                  75                  80  


Glu Leu Ser Ile Phe Asp Pro Pro Pro Phe Gln Lys Lys Asn Ile Ser 
                85                  90                  95      


Arg Glu Tyr Leu Asn Ile Tyr Glu Ser Gln Ile Cys Cys Gln Leu Lys 
            100                 105                 110         


Phe Trp Leu Pro Ile Gly Cys Ser Ala Phe Val Val Val Tyr Ile Phe 
        115                 120                 125             


Gly Cys Val Phe Leu Cys Trp Leu Thr Lys Lys Lys Tyr Arg Ser Ser 
    130                 135                 140                 


Gly His Asp Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr 
145                 150                 155                 160 


Ala Lys Lys Pro Gly Leu Thr Gly Val Thr His Asn Leu Glu Leu Cys 
                165                 170                 175     


Gly Thr Gln Ala 
            180 


<210>  7
<211>  209
<212>  PRT
<213>  Bos taurus

<400>  7

Met Lys Ser Asp Leu Arg Tyr Phe Phe Leu Phe Cys Ile Gln Val Glu 
1               5                   10                  15      


Ile Leu Ala Gly Glu Phe Asn Asp Ser Ala Ala Ser Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Thr Val 
        35                  40                  45              


Arg Gln Phe Lys Met Gln Leu Leu Lys Gly Asp Asn Val Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Glu Asn Glu Asp Thr Val Ser Ile Arg Asn Leu 
65                  70                  75                  80  


Asn Val Cys Lys Phe Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Ser Ser Tyr Ala Ser Tyr Tyr Ile Cys Lys Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Val Asp Ile Leu Ser Arg Glu Tyr 
        115                 120                 125             


Leu Asn Ile Tyr Glu Ser Glu Leu Cys Cys Gln Leu Lys Phe Trp Leu 
    130                 135                 140                 


Pro Ile Gly Cys Ala Ala Phe Val Thr Val Cys Val Phe Gly Cys Val 
145                 150                 155                 160 


Leu Met Tyr Trp Leu Thr Lys Lys Lys Tyr Pro Thr Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Ala Lys Lys 
            180                 185                 190         


Pro Ala Pro Thr Asp Val Thr Arg Asn Leu Glu Leu Pro Gly Thr Gln 
        195                 200                 205             


Ala 
    


<210>  8
<211>  209
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  8

Met Lys Ser Asp Leu Trp Tyr Phe Leu Leu Phe Cys Phe Gln Val Glu 
1               5                   10                  15      


Ala Leu Thr Gly Glu Ile Asn Asp Ser Ala Lys Ser Glu Met Phe Thr 
            20                  25                  30          


Phe His Asp Gly Gly Val Gln Ile Leu Cys Lys Phe Ser Asp Thr Val 
        35                  40                  45              


Trp Gln Phe Lys Met Lys Leu Trp Lys Gly Thr Glu Val Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Glu Ser Gly Asn Thr Glu Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Lys Ser Cys Gln Ser Gln Leu Ser Asn Asp Gly Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Leu Asp Ser Ser His Ala Ser Tyr Tyr Ala Cys Glu Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Lys Lys Asn Ile Ser Arg Glu Tyr 
        115                 120                 125             


Leu Asn Val Tyr Glu Ser Gln Thr Cys Cys Gln Leu Lys Phe Trp Leu 
    130                 135                 140                 


Pro Ile Gly Cys Ala Ala Phe Val Val Val Tyr Ile Phe Gly Cys Val 
145                 150                 155                 160 


Phe Leu Cys Trp Leu Thr Lys Lys Lys Tyr Arg Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Ala Lys Lys 
            180                 185                 190         


Pro Gly Val Thr Gly Val Thr His Asn Leu Glu Leu Cys Gly Thr Gln 
        195                 200                 205             


Ala 
    


<210>  9
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  9

Met Lys Pro Tyr Phe Cys Arg Val Phe Val Phe Cys Phe Leu Ile Arg 
1               5                   10                  15      


Leu Leu Thr Gly Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Val Val Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Leu Ile Ile Trp Phe Ser Lys Lys Lys Tyr Gly Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Val Thr Ser 
        195                 200 


<210>  10
<211>  200
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Lys Pro Tyr Phe Ser Cys Val Phe Val Phe Cys Phe Leu Ile Lys 
1               5                   10                  15      


Leu Leu Thr Gly Glu Leu Asn Asp Leu Ala Asn His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asp Gly Gly Val Gln Ile Ser Cys Asn Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Gln Leu Phe Lys Asp Arg Glu Val Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Ser Cys Pro Tyr Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asp Asn Ala Asp Ser Ser Gln Gly Ser Tyr Phe Leu Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Lys Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu Leu Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Ala Ala Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Phe Ile Val Trp Phe Ala Lys Lys Lys Tyr Arg Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Met Thr Ser 
        195                 200 


<210>  11
<211>  203
<212>  PRT
<213>  Taeniopygia guttata

<400>  11

Met Lys Ser Asp Leu Trp Tyr Phe Phe Leu Phe Cys Phe Gln Val Glu 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Asp Ser Ala Lys Tyr Glu Met Phe Thr 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Val Cys Lys Tyr Pro Glu Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Glu Gln Val Leu Cys Asp 
    50                  55                  60                  


Leu Arg Gln Thr Lys Glu Ser Gly Asn Thr Val Ser Ile Lys Ala Leu 
65                  70                  75                  80  


Lys Phe Cys Gln Tyr Gln Leu Phe Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Ser Ser His Ala Ser Tyr Tyr Phe Cys Lys Leu Ser 
            100                 105                 110         


Thr Phe Asp Pro Pro Pro Phe Gln Val Glu Ile Leu Arg Gly Glu Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu 
    130                 135                 140                 


Pro Ile Gly Cys Ala Ala Phe Ala Val Val Tyr Ile Phe Gly Cys Val 
145                 150                 155                 160 


Phe Ile Phe Trp Leu Thr Lys Lys Lys Tyr Gln Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Ala Lys Lys 
            180                 185                 190         


Pro Thr Pro Pro Glu Leu Ser Gly Thr Arg Ala 
        195                 200             


<210>  12
<211>  360
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Met Lys Ser Gly Ile Leu Ala Cys Leu Ile Phe Phe Gln Phe Glu Ala 
1               5                   10                  15      


Leu Ser Ala Arg Asn Arg His Arg Glu Arg Lys Lys Gln Lys Ser Pro 
            20                  25                  30          


Gln Lys Ala Ala Glu Thr Thr Ala Lys Met Gly Gly Glu Glu Ala Thr 
        35                  40                  45              


Arg Arg Lys Glu Gly Val Glu Ala Trp Arg Ala Ser Glu Glu Pro Cys 
    50                  55                  60                  


Trp Glu Gly Gly Arg Asn Leu Arg Ser Arg Phe Arg Lys Lys Ile Gln 
65                  70                  75                  80  


Pro His Ser His Ile Pro Phe Arg Lys Lys Thr Asp Ala Glu Glu Val 
                85                  90                  95      


Gly Met Ser Asn Pro Gly Ala Ala Ser Phe Met Thr Gln Ile Leu Trp 
            100                 105                 110         


Leu Thr Gln Ser His Leu Ser Lys Ile Ala Leu Ile Trp Leu Val Ile 
        115                 120                 125             


Ser Ser Ser Asp Thr Lys Ile Ile Cys Phe Phe Ile Ala Ser Leu Arg 
    130                 135                 140                 


Lys Gly Ala Arg Thr Leu Asn Ala Ile Thr Phe Val Leu Gly Leu Val 
145                 150                 155                 160 


Asp Pro Leu Pro Ser Gln Glu Thr Lys Pro Cys Glu Glu Lys Leu Gly 
                165                 170                 175     


Gln Thr Ile Glu Glu Ser Asn Ala Thr Ala His Gln Lys Met Met Ala 
            180                 185                 190         


Phe His Asn Gly Val Val Lys Val Thr Cys His Tyr Pro Arg Ser Ala 
        195                 200                 205             


Arg Asp Phe Thr Met Gln Leu Leu Lys Gly Thr Met Arg Gln Lys Val 
    210                 215                 220                 


Cys Glu Leu Ile Arg Asp Lys Asp Ile Thr Asn Thr Thr Thr Gln Lys 
225                 230                 235                 240 


Glu Leu Ile Tyr Cys Gln Pro Asp Leu Ser Asn Asp Ser Val Ile Phe 
                245                 250                 255     


Thr Leu Ser Asn Leu Asp Ile Arg His Ala Asp Tyr Tyr Phe Cys Ser 
            260                 265                 270         


Leu Glu Val Ser Phe Pro Pro Pro Tyr Gln Asn Cys Thr Pro Asp Glu 
        275                 280                 285             


Ala Tyr Leu Tyr Val Tyr Glu Ser Lys Phe Cys Ser Lys Leu Thr Phe 
    290                 295                 300                 


Trp Leu Pro Val Gly Leu Ala Val Phe Ser Met Leu Ser Cys Ile Cys 
305                 310                 315                 320 


Cys Ile Leu Ala Phe Trp Leu Arg Asn Lys Ser Asn Gln Cys Pro Ser 
                325                 330                 335     


Ser Leu His Glu Pro Asn Ser Glu Tyr Met Pro Met Ala Ala Val Thr 
            340                 345                 350         


Ala Ala Lys Lys Ser Gly Phe Arg 
        355                 360 


<210>  13
<211>  229
<212>  PRT
<213>  Meleagris gallopavo

<400>  13

Met Phe Thr Ala Asp Arg Lys Leu Met Pro Leu Cys Gln Ala Ser Met 
1               5                   10                  15      


Lys Ser Val Ala Val Thr Phe Tyr Leu Phe Cys Phe Gln Phe Glu Ala 
            20                  25                  30          


Leu Cys Gly Ala Asp Thr Cys Ser Ser Arg Leu Cys Lys Asn Ile Asp 
        35                  40                  45              


Lys Leu Gln Val Ser Asp Pro Gln Gly Ile Val Lys Phe Glu Asn Gly 
    50                  55                  60                  


Asn Phe Lys Leu Ile Phe Gln Asn Pro Lys Asn Val Ser Glu Phe Ser 
65                  70                  75                  80  


Met Thr Leu Leu Lys Gly His Glu Arg Lys Ala Ile Cys Ala Leu His 
                85                  90                  95      


Val Ser Lys Asn Lys Ala Val Pro Glu Ser Asn Val Thr Tyr Cys Gln 
            100                 105                 110         


Ala Glu His Ser Asn Thr Ser Thr Thr Phe Ile Leu Thr Asn Leu Asp 
        115                 120                 125             


Arg Lys His Ile Asp Thr Tyr Thr Cys Cys Leu Glu Ser Leu Leu Pro 
    130                 135                 140                 


Pro Pro Tyr Ile Asp Cys His Leu Lys Glu Thr Tyr Leu Tyr Ile Gln 
145                 150                 155                 160 


Asp Lys Glu Asp Cys Phe Ser Gln Gly Ile Met Ser Trp Ile Ile Ile 
                165                 170                 175     


Gly Leu Ile Ala Phe Ala Leu Ile Ser Cys Val Cys Cys Val Ile Ala 
            180                 185                 190         


Cys Ser Leu Arg Asn Lys Asn Gln Gln Cys Glu Ser Ser Ser His Glu 
        195                 200                 205             


Tyr Asn Ser Glu Tyr Met Pro Met Ala Ala Val Asn Ala Ala Lys Asn 
    210                 215                 220                 


Gln Glu Ser Glu Val 
225                 


<210>  14
<211>  212
<212>  PRT
<213>  Gallus gallus

<400>  14

Met Lys Thr Val Ala Val Thr Phe Cys Leu Leu Cys Phe Gln Phe Glu 
1               5                   10                  15      


Ala Leu Cys Gly Val Asp Thr Cys Ser Ser Arg Leu Cys Lys Asn Ile 
            20                  25                  30          


Asp Lys Leu Gln Val Ser Asp Pro Gln Gly Ile Val Glu Phe Glu Asn 
        35                  40                  45              


Gly Asn Phe Lys Leu Ile Phe Gln Asn Pro Lys Asn Val Asn Glu Phe 
    50                  55                  60                  


Ser Met Thr Leu Leu Lys Gly Arg Glu Arg Lys Ala Ile Cys Ala Leu 
65                  70                  75                  80  


His Met Asn Asn Lys Lys Ala Val Pro Glu Ser Asn Val Thr Tyr Cys 
                85                  90                  95      


Gln Ala Glu His Ser Asp Thr Ser Thr Thr Phe Ile Leu Thr Asn Leu 
            100                 105                 110         


Asp Arg Lys His Ile Asp Thr Tyr Thr Cys Cys Leu Glu Ser Leu Leu 
        115                 120                 125             


Pro Pro Pro Tyr Ile His Cys His Leu Lys Glu Thr Tyr Leu Tyr Ile 
    130                 135                 140                 


Gln Asp Lys Glu Asp Cys Ser Ser Gln Gly Ile Met Ser Trp Ile Ile 
145                 150                 155                 160 


Ile Gly Leu Ile Ala Phe Ala Leu Ile Phe Cys Val Cys Phe Val Val 
                165                 170                 175     


Ala Cys His Leu Arg Asn Lys Asn Gln Gln Cys Glu Ser Asn Ser His 
            180                 185                 190         


Glu Tyr Asn Ser Glu Tyr Met Pro Met Ala Ala Val Asn Ala Ala Lys 
        195                 200                 205             


Lys Pro Arg Ile 
    210         


<210>  15
<211>  212
<212>  PRT
<213>  Anas platyrhynchos

<400>  15

Met Lys Ser Val Ala Val Thr Leu Cys Leu Leu Cys Phe Gln Phe Gly 
1               5                   10                  15      


Ala Leu Cys Gly Ala Asp Thr Cys Ser Ser Arg Pro Cys Lys Asn Ile 
            20                  25                  30          


Asp Gln Leu His Val Ser Asp Ser Gln Val Met Val Glu Phe Asn Ser 
        35                  40                  45              


Gly Thr Phe Lys Phe Ile Phe His Asn Pro Lys Asn Val Ser Glu Phe 
    50                  55                  60                  


Ser Met Thr Leu Phe Lys Gly His Glu Lys Lys Glu Ile Cys Ala Leu 
65                  70                  75                  80  


His Val Ser Lys Glu Lys Ala Ile Pro Lys Ser Asn Val Thr Tyr Cys 
                85                  90                  95      


Gln Ala Glu His Ser Asn Thr Ser Thr Thr Phe Ile Leu Thr Asn Leu 
            100                 105                 110         


Glu Arg Lys His Ile Asp Thr Tyr Thr Tyr Cys Leu Glu Met Phe Leu 
        115                 120                 125             


Pro Pro Pro Tyr Ile Asp Cys Arg Leu Lys Glu Thr Tyr Leu Tyr Ile 
    130                 135                 140                 


Gln Asp Lys Glu Asp Cys Ile Ser Leu Gly Leu Met Thr Trp Val Thr 
145                 150                 155                 160 


Ile Gly Leu Ile Val Phe Ala Met Ile Ser Cys Val Cys Cys Val Ala 
                165                 170                 175     


Ala Cys Arg Leu Arg Asn Lys Asn Gln Gln Cys Glu Ser Asn Ser His 
            180                 185                 190         


Glu Tyr Asn Ser Glu Tyr Met Pro Met Ala Ala Val Asn Ala Ala Lys 
        195                 200                 205             


Lys Thr Arg Ile 
    210         


<210>  16
<211>  211
<212>  PRT
<213>  Taeniopygia guttata

<400>  16

Met Lys Ala Val Ala Val Thr Phe Cys Val Leu Cys Phe Gln Phe Glu 
1               5                   10                  15      


Ala Leu Tyr Gly Val Asp Gly Cys Ser Ser Cys Ala Cys Lys Asn Ile 
            20                  25                  30          


Asp Gln Ala His Val Ser Asp Gly Glu Val Met Val Glu Phe Glu Asn 
        35                  40                  45              


Gly Asn Phe His Phe Thr Phe Pro Asn Pro Lys Ser Val Ser Glu Phe 
    50                  55                  60                  


Ser Met Thr Leu Phe Lys Gly Arg Glu Lys Lys Glu Ile Cys Ala Ile 
65                  70                  75                  80  


His Leu Ser Lys Glu Arg Val Ile Ser Lys Ser Asn Val Thr Tyr Cys 
                85                  90                  95      


Gln Thr Gln Asn Ser Ser Ser Ser Thr Ile Phe Ile Leu Lys Asn Leu 
            100                 105                 110         


Gly Lys Lys His Ile Asp Val Tyr Thr Cys Cys Leu Glu Ile Phe Leu 
        115                 120                 125             


Pro Pro Pro Tyr Ile Glu Arg Cys Leu Lys Glu Thr Phe Leu Tyr Ile 
    130                 135                 140                 


Gln Asp Lys Glu Asp Cys Phe Ser Leu Gly Leu Met Leu Trp Ile Ile 
145                 150                 155                 160 


Ile Gly Val Ile Ile Phe Ala Ile Ser Cys Val Cys Cys Val Val Ala 
                165                 170                 175     


Cys Cys Leu Arg Asn Lys Asn Gln Lys Cys Glu Ser Asn Ser His Glu 
            180                 185                 190         


Tyr Asn Ser Glu Tyr Met Pro Met Ala Ala Val Asn Ala Ala Lys Lys 
        195                 200                 205             


Pro Arg Ile 
    210     


<210>  17
<211>  210
<212>  PRT
<213>  Xenopus Tropicalis

<400>  17

Met Asn Val Asn Leu Thr Gly Phe Pro Leu Phe Ile Leu Leu Val Leu 
1               5                   10                  15      


His Ala Gln Leu Ser Lys Ser Tyr Pro Lys Val Val Ile Ala Ser Gln 
            20                  25                  30          


Asp Gly Glu Pro Cys Leu Leu Cys His His Val Pro Ser Thr Asp Ser 
        35                  40                  45              


Lys Phe Asn Leu Thr Leu Met Arg Gly Asn Lys Lys Gln Glu Val Cys 
    50                  55                  60                  


Met Val Tyr Thr Asp Gly Lys Asn Thr Ser Phe Tyr Ser Trp Asn Asp 
65                  70                  75                  80  


Asn Pro Lys Cys Asn Trp Thr Lys Ser Asn Asp Ser Ser Ile Ser Phe 
                85                  90                  95      


Thr Leu Ser Asn Phe Asp Ile Lys His Thr Asp Asn Tyr Thr Cys Glu 
            100                 105                 110         


Ile Arg Ile Phe Tyr Pro Pro Pro Phe Arg Ser Ile Ile Ile Asn Glu 
        115                 120                 125             


Thr Tyr Val Tyr Ile His Asp Leu Gln Gln Cys Gly Ser Gly Met Gln 
    130                 135                 140                 


Glu Phe Ile Ile Trp Ile Leu Thr Gly Leu Ala Val Phe Leu Phe Leu 
145                 150                 155                 160 


Cys Cys Ile Phe Thr Phe Cys Leu Trp Ile Gln Asn Arg Phe Arg Arg 
                165                 170                 175     


Lys Cys Leu Ser Gln Gly Asn Thr Gln Asn Asn Glu Cys Asn Ser Glu 
            180                 185                 190         


Tyr Met Pro Met Ala Ser Val Asn Pro Ala Lys Arg Pro Val Ile Pro 
        195                 200                 205             


Arg Leu 
    210 


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proximal Motif from ICOS canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X may be present or absent, and when present may be S.

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  Each X may be independently any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Each X may be independently any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X may be any amino acid, but preferably is D or E.

<400>  18

Xaa Ser Ser Xaa Xaa Xaa Pro Xaa Xaa Xaa 
1               5                   10  


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YXXM Motif from ICOS


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X may be any amino acid, but preferably may be M

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X may be any amino acid, but preferably may be F or P

<400>  19

Tyr Xaa Xaa Met 
1               


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Distal Motif of ICOS


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X may be any amino acid, but preferably is A or S

<400>  20

Xaa Val Asn Thr Ala Lys Lys 
1               5           


<210>  21
<211>  199
<212>  PRT
<213>  artificial sequence

<220>
<223>  hICOS modified with proximal motif poly A

<400>  21

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ala Ala Ala Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  22
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Poly A proximal motif alone

<400>  22

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10  


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Leu Glu Ser Gly Gly Gly Gly 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hICOS proximal motif alone

<400>  24

Ser Ser Ser Val His Asp Pro Asn Gly Glu 
1               5                   10  


<210>  25
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  hICOS YXXM Motif alone

<400>  25

Tyr Met Phe Met 
1               


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  hICOS distal motif alone

<400>  26

Ala Val Asn Thr Ala Lys Lys 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived frmo pan troglodytes

<400>  27

Ser Ser Ser Val His Asp Pro Asn Gly Glu 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  proximal motif derived from pongo abelii

<400>  28

Ser Ser Ser Val His Asp Pro Asn Gly Glu 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  proximal motif derived from Macaca mulatta

<400>  29

Ser Ser Thr Val His Asp Pro Asn Gly Glu 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  proximal motif derived from Canis Familiaris

<400>  30

Ser Ser Thr Val His Asp Pro Asn Gly Glu 
1               5                   10  


<210>  31
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  proximal motif derived from Felis catus

<400>  31

Ser Ser Gly His Asp Pro Asn Ser Glu 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  proximal motif derived from Bos Taurus

<400>  32

Thr Ser Val His Asp Pro Asn Ser Glu 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Ailuropoda melanoleuca

<400>  33

Ser Ser Val His Asp Pro Asn Ser Glu 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from mus musculus

<400>  34

Ser Ser Val His Asp Pro Asn Ser Glu 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Rattus norvegicus

<400>  35

Ser Ser Val His Asp Pro Asn Ser Glu 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Oryctolagus cuniculus

<400>  36

Ser Ser Val His Asp Pro Asn Ser Glu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Meleagris gallopavo

<400>  37

Ser Ser Leu His Glu Pro Asn Ser Glu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Anas platyrhynchos

<400>  38

Ser Asn Ser His Glu Tyr Asn Ser Glu 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Taeniopygia guttata

<400>  39

Ser Asn Ser His Glu Tyr Asn Ser Glu 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Proximal motif derived from Xenopus tropicalis

<400>  40

Thr Gln Asn Asn Glu Cys Asn Ser Glu 
1               5                   


<210>  41
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  alternate YXXM motif

<400>  41

Tyr Met Pro Met 
1               


<210>  42
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Homo sapiens

<400>  42

Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
1               5                   10                  15      


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
            20                  25                  30      


<210>  43
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  C termimnal derived from Pan troglodytes

<400>  43

Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
1               5                   10                  15      


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
            20                  25                  30      


<210>  44
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Pongo abelii

<400>  44

Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
1               5                   10                  15      


Arg Ala Val Asn Thr Ala Lys Lys Ser Lys Leu Thr Asp Val Thr Ile 
            20                  25                  30          


<210>  45
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Macaca mulatta

<400>  45

Lys Tyr Ser Ser Thr Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
1               5                   10                  15      


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Gly Thr Thr 
            20                  25                  30      


<210>  46
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Canis Familiaris

<400>  46

Lys Tyr Arg Ser Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Ala Lys Lys Pro Gly Leu Thr Gly Val Thr His 
            20                  25                  30          


Asn Leu Glu Leu Cys Gly Thr Gln Ala 
        35                  40      


<210>  47
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Felis catus

<400>  47

Lys Tyr Arg Ser Ser Gly His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Ala Lys Lys Pro Gly Leu Thr Gly Val Thr His 
            20                  25                  30          


Asn Leu Glu Leu Cys Gly Thr Gln Ala 
        35                  40      


<210>  48
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Bos Taurus

<400>  48

Lys Tyr Pro Thr Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Ala Lys Lys Pro Ala Pro Thr Asp Val Thr Arg 
            20                  25                  30          


Asn Leu Glu Leu Pro Gly Thr Gln Ala 
        35                  40      


<210>  49
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Ailuopoda melanoleuca

<400>  49

Lys Tyr Arg Ser Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Ala Lys Lys Pro Gly Val Thr Gly Val Thr His 
            20                  25                  30          


Asn Leu Glu Leu Cys Gly Thr Gln Ala 
        35                  40      


<210>  50
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Mus musculus

<400>  50

Lys Tyr Gly Ser Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Asn Lys Lys Ser Arg Leu Ala Gly Thr Ala 
            20                  25                  30      


<210>  51
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Rattus norvegicus

<400>  51

Lys Tyr Arg Ser Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Asn Lys Lys Ser Arg Leu Ala Gly Met Thr Ser 
            20                  25                  30          


<210>  52
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  C term derived from Oryctolagus cuniculus

<400>  52

Lys Tyr Gln Ser Ser Val His Asp Pro Asn Ser Glu Tyr Met Phe Met 
1               5                   10                  15      


Ala Ala Val Asn Thr Ala Lys Lys Pro Thr Pro Pro Val Ile Leu 
            20                  25                  30      


<210>  53
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  C term derived from Ornithorhynchus anatinus

<400>  53

Gln Cys Pro Ser Ser Leu His Glu Pro Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ala Val Thr Ala Ala Lys Lys Ser Gly Phe Arg 
            20                  25              


<210>  54
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Meleagris gallopavo

<400>  54

Gln Cys Glu Ser Ser Ser His Glu Tyr Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ala Val Asn Ala Ala Lys Lys Pro Arg Ile 
            20                  25          


<210>  55
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Gallus gallus

<400>  55

Gln Cys Glu Ser Asn Ser His Glu Tyr Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ala Val Asn Ala Ala Lys Lys Pro Arg Ile 
            20                  25          


<210>  56
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Anas platyrhynchos

<400>  56

Gln Cys Glu Ser Asn Ser His Glu Tyr Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ala Val Asn Ala Ala Lys Lys Thr Arg Ile 
            20                  25          


<210>  57
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Taeniopygia guttata

<400>  57

Lys Cys Glu Ser Asn Ser His Glu Tyr Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ala Val Asn Ala Ala Lys Lys Pro Arg Ile 
            20                  25          


<210>  58
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  C terminal derived from Xenopus tropicalis

<400>  58

Gln Gly Asn Thr Gln Asn Asn Glu Cys Asn Ser Glu Tyr Met Pro Met 
1               5                   10                  15      


Ala Ser Val Asn Pro Ala Lys Arg Pro Val Ile Pro Arg Leu 
            20                  25                  30  


<210>  59
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Short Hairpin RNA targeting Tbk1 gene.

<400>  59
aagacataaa gtgcttatta tg                                                22


<210>  60
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  short hairpin RNA targeting ICOS gene.

<400>  60
ttcagttaat atggtttact at                                                22


<210>  61
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCMV gp61-80 peptide

<400>  61

Gly Leu Asn Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser 
1               5                   10                  15      


Val Glu Phe Asp 
            20  


<210>  62
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Icos Forward primer

<400>  62
actggtgatc tctatgctgt ca                                                22


<210>  63
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Icos Reverse primer

<400>  63
ttctggaagt ccatacgcat tg                                                22


<210>  64
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Tbk1 Forward primer

<400>  64
tgacccacct ccttttcaag                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Tbk1 Reverse primer

<400>  65
ttagggtcat gcacactgga                                                   20


<210>  66
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from Homo sapiens

<400>  66

Ser Ser Ser Phe Gln Arg Pro Val Asn Asp 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from Mus Musculus

<400>  67

Ser Ser Ser Phe Gln Arg Pro Val Ser Asp 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from Gallus gallus

<400>  68

Ser Ser Ser Phe Gln Arg Pro Val Thr Glu 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from Dario rerio

<400>  69

Ser Ser Ser Phe Gln Arg Pro Val Ser Asp 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from Branchiostoma floridae

<400>  70

Ser Ser Ser Phe Lys Arg Pro Thr Ser Asp 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF2 Serine Tongs derived from amphimedon queenslandica

<400>  71

Ser Ser Ser Phe Gln Arg Pro Lys Ser Asp 
1               5                   10  


<210>  72
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg 
        115                 120                 125             


Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys 
                165                 170                 175     


Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr 
        195                 200                 205             


Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu 
    210                 215                 220                 


Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro 
                245                 250                 255     


Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Gly Cys 
            260                 265                 270         


Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys Ser 
    290                 295                 300                 


Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala Pro Ser Ser Lys 
305                 310                 315                 320 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                325                 330                 335     


Asp Leu Glu Gln Lys Val Ser Glu Met Glu Ala Ser Thr Tyr Asp Gly 
            340                 345                 350         


Val Phe Ile Trp Lys Ile Ser Asp Phe Ala Arg Lys Arg Gln Glu Ala 
        355                 360                 365             


Val Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Arg 
    370                 375                 380                 


Arg Tyr Gly Tyr Lys Met Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly 
385                 390                 395                 400 


Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val Val Met Lys Gly 
                405                 410                 415     


Pro Asn Asp Ala Leu Leu Arg Trp Pro Phe Asn Gln Lys Val Thr Leu 
            420                 425                 430         


Met Leu Leu Asp Gln Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg 
        435                 440                 445             


Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val Asn Asp Met Asn 
    450                 455                 460                 


Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser Lys Met Glu Ala 
465                 470                 475                 480 


Lys Asp Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile Lys Ala Ile Val 
                485                 490                 495     


Asp Leu Thr Gly Leu 
            500     


<210>  73
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  73

Met Ala Ala Ala Ser Val Thr Ser Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Arg Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Lys Asn Ile Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Thr Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val Tyr Glu Gly Leu Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Asn Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Leu 
        115                 120                 125             


Cys Pro Phe Leu Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Ser Glu Lys Glu His His Thr Glu Gln Glu Cys Pro Lys Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Gln His Cys Arg Ala Pro Cys Ser His Val Asp Leu Glu 
                165                 170                 175     


Val His Tyr Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Thr Phe Gln Asp His Val Arg Ala 
        195                 200                 205             


Cys Ser Lys Cys Arg Val Leu Cys Arg Phe His Thr Val Gly Cys Ser 
    210                 215                 220                 


Glu Met Val Glu Thr Glu Asn Leu Gln Asp His Glu Leu Gln Arg Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Leu Leu Leu Ser Ser Phe Leu Glu Ala Gln Ala 
                245                 250                 255     


Ser Pro Gly Thr Leu Asn Gln Val Gly Pro Glu Leu Leu Gln Arg Cys 
            260                 265                 270         


Gln Ile Leu Glu Gln Lys Ile Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Val Thr Ala Glu Ala Cys Ser 
    290                 295                 300                 


Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala Leu Ser Asn Lys 
305                 310                 315                 320 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                325                 330                 335     


Asp Leu Glu Gln Lys Val Ser Glu Leu Glu Val Ser Thr Tyr Asp Gly 
            340                 345                 350         


Val Phe Ile Trp Lys Ile Ser Asp Phe Thr Arg Lys Arg Gln Glu Ala 
        355                 360                 365             


Val Ala Gly Arg Thr Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser 
    370                 375                 380                 


Arg Tyr Gly Tyr Lys Met Cys Leu Arg Val Tyr Leu Asn Gly Asp Gly 
385                 390                 395                 400 


Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val Val Met Lys Gly 
                405                 410                 415     


Pro Asn Asp Ala Leu Leu Gln Trp Pro Phe Asn Gln Lys Val Thr Leu 
            420                 425                 430         


Met Leu Leu Asp His Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg 
        435                 440                 445             


Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val Ser Asp Met Asn 
    450                 455                 460                 


Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser Lys Met Glu Ala 
465                 470                 475                 480 


Lys Asn Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile Lys Ala Ile Val 
                485                 490                 495     


Asp Leu Thr Gly Leu 
            500     


<210>  74
<211>  527
<212>  PRT
<213>  Gallus gallus

<400>  74

Met Ala Ala Ala Asn Ser Thr Pro Pro Gly Ser Leu Asp Leu Ser Gln 
1               5                   10                  15      


Pro Gly Phe Ala Lys Glu Ile Leu Gly Thr Lys Leu Glu Val Lys Tyr 
            20                  25                  30          


Leu Cys Ser Asp Cys Arg Asn Ile Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Tyr Cys Leu Lys Lys Ile Ile Ser Ser 
    50                  55                  60                  


Gly Pro Gln Lys Cys Ala Ser Cys Ile Gln Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Thr Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Ile Asn Glu Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Ile Lys Glu Tyr Glu Ser Cys His Glu Gly Asn 
        115                 120                 125             


Cys Pro Phe Leu Leu Ile Glu Cys Gln Ala Cys Arg Gly Val Ile Pro 
    130                 135                 140                 


Leu Asn Glu Lys Glu Arg His Ser Glu Arg Glu Cys Pro Glu Arg Thr 
145                 150                 155                 160 


Leu Asn Cys Lys Tyr Cys Lys Ser Leu Phe Tyr Phe Pro Asp Ile Lys 
                165                 170                 175     


Ala His Asp Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Asn 
        195                 200                 205             


Cys Gly Lys Cys Lys Val Pro Cys Arg Phe Lys Val Val Gly Cys Ala 
    210                 215                 220                 


Glu Met Val Glu Asn Glu Lys Leu Pro Glu His Glu Ser Lys Cys Leu 
225                 230                 235                 240 


Ala Glu His Leu Tyr Met Leu Leu Ser Phe Val Leu Ser Leu Lys Ser 
                245                 250                 255     


Gly Ser Gly Asp Leu Lys His Leu Pro Ala Ile Pro Ser Ser Gln Ser 
            260                 265                 270         


Ser Ser Pro Leu Leu Ala Ala Asn Ser Leu Cys Pro Glu Ser Glu Leu 
        275                 280                 285             


Phe Lys Ser Leu Glu Leu Leu Gly Arg Cys Asp Ala Leu Glu Lys Lys 
    290                 295                 300                 


Thr Val Thr Phe Glu Asn Ile Val Cys Val Leu Asn Arg Glu Val Glu 
305                 310                 315                 320 


Arg Val Ser Leu Thr Ala Glu Ala Tyr Ser Arg Gln His Arg Leu Asp 
                325                 330                 335     


Gln Glu Gln Ile Glu Thr Leu Ser Asn Lys Val Arg Gln Leu Glu Arg 
            340                 345                 350         


Ser Ile Gly Leu Lys Asp Leu Ala Met Ala Glu Met Glu Glu Lys Ile 
        355                 360                 365             


Arg Asn Met Glu Ala Ser Thr Tyr Asp Gly Val Phe Ile Trp Lys Ile 
    370                 375                 380                 


Thr Glu Phe Ala Arg Lys Arg Gln Glu Ala Ile Thr Gly Arg Ser Pro 
385                 390                 395                 400 


Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser Lys Tyr Gly Tyr Lys Met 
                405                 410                 415     


Cys Leu Arg Val Tyr Leu Asn Gly Asp Gly Thr Gly Arg Gly Thr His 
            420                 425                 430         


Leu Ser Leu Phe Phe Val Val Met Lys Gly Pro Asn Asp Ala Leu Leu 
        435                 440                 445             


Arg Trp Pro Phe Asn Gln Lys Val Thr Leu Met Leu Leu Asp Gln Asn 
    450                 455                 460                 


Asn Arg Glu His Ile Ile Asp Ala Phe Arg Pro Asp Val Thr Ser Ser 
465                 470                 475                 480 


Ser Phe Gln Arg Pro Val Thr Glu Met Asn Ile Ala Ser Gly Cys Pro 
                485                 490                 495     


Leu Phe Cys Pro Val Ser Val Met Glu Ala Lys Asn Ser Tyr Val Arg 
            500                 505                 510         


Asp Asp Ala Ile Phe Ile Lys Ala Ile Val Asp Leu Ser Gly Leu 
        515                 520                 525         


<210>  75
<211>  575
<212>  PRT
<213>  danio rerio

<400>  75

Met Ala Ala Gln Glu Pro Ser Pro Pro Ser Ser Leu Glu Gly Asn Lys 
1               5                   10                  15      


Pro Gly Phe Pro Lys Lys Ile Leu Ala Asn Lys Leu Glu Asp Lys His 
            20                  25                  30          


Leu Cys Asn Ile Cys Leu Lys Ile Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Phe Cys Ser Tyr Cys Phe Asn Lys Ala Val Ser Ser 
    50                  55                  60                  


Gly Pro Gln Lys Cys Ser Ala Cys Ile Lys Glu Asp Ile Phe Glu Glu 
65                  70                  75                  80  


Pro Thr Ser Ile Leu Lys Gln Gly Cys Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Lys Arg Glu Val Glu Ala Leu Glu Ala Val Cys Ile Asn Glu Glu Cys 
            100                 105                 110         


Ser Trp Thr Gly Thr Ile Lys Glu Tyr Glu Ala Asn His Glu Gly Lys 
        115                 120                 125             


Cys Asp Phe Arg Ile Leu Pro Cys Pro Ser Cys Lys Glu Leu Leu Arg 
    130                 135                 140                 


Ala Asn Glu Leu Glu Arg His Asn Glu Arg Glu Cys Pro Glu Arg Thr 
145                 150                 155                 160 


Leu Asn Cys Lys Tyr Cys Lys Glu Pro Phe His Phe Lys Asn Ile Lys 
                165                 170                 175     


Ala His Asp Glu Ile Cys Pro Lys Tyr Pro Met Ile Cys Glu Gly Cys 
            180                 185                 190         


Ala Lys Lys Lys Ile Pro Arg Glu Lys Tyr Val Asp His Ile Lys Leu 
        195                 200                 205             


Cys Thr Lys Phe Arg Thr Pro Cys Arg Phe His Val Val Gly Cys Asp 
    210                 215                 220                 


Met Thr Val Glu Lys Glu Lys Ile His Asp His Glu Gln Ala Cys Ser 
225                 230                 235                 240 


Tyr Glu His Leu Asn Leu Leu Leu His Phe Ile Met Gly Ile Lys Val 
                245                 250                 255     


Asn Leu Glu Ser Leu Gln Pro Gln Ser Leu Glu Leu Ala Ser His Lys 
            260                 265                 270         


Ile His Glu Leu His Gln Ser Leu Arg Glu Leu Glu Leu Lys Met Gly 
        275                 280                 285             


Gln Leu Cys Gly Ala Gly Ala Ser Val Gln Gly Ala Cys Ala Leu Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Ala Pro Thr Leu Gly Thr Ser Phe Thr Pro Leu 
305                 310                 315                 320 


Pro Thr Ala Val Gly Ala Ala Leu Glu Leu Gln Leu His Ser Glu Lys 
                325                 330                 335     


Thr Lys Val Val Glu Leu Ser Arg Arg Cys Gln Glu Leu Glu Leu Lys 
            340                 345                 350         


Val Asn Thr Phe Glu Asn Ile Val Cys Val Leu Asn Arg Glu Met Glu 
        355                 360                 365             


Arg Ser Ala Thr Thr Met Glu Ala Tyr Asn Arg Gln His Arg Leu Asp 
    370                 375                 380                 


Gln Asp Lys Ile Glu Ile Leu Asn Asn Lys Val Arg Gln Leu Glu Arg 
385                 390                 395                 400 


Thr Val Gly Leu Arg Asp Leu Ser Ile Val Glu Met Glu Ala Lys Met 
                405                 410                 415     


Arg Glu Met Ser Ala Ala Thr Tyr Asp Gly Val Phe Val Trp Lys Ile 
            420                 425                 430         


Ser Asp Phe Ser Lys Lys Arg Gln Asp Ala Val Ala Gly Arg Ala Pro 
        435                 440                 445             


Ala Met Phe Ser Pro Ala Phe Tyr Thr Ser Lys Tyr Gly Tyr Lys Met 
    450                 455                 460                 


Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly Thr Gly Arg Gly Thr His 
465                 470                 475                 480 


Leu Ser Leu Phe Phe Val Val Met Arg Gly His Ser Asp Ala Leu Leu 
                485                 490                 495     


Lys Trp Pro Phe Asn Gln Lys Val Thr Leu Met Leu Leu Asp Gln Asn 
            500                 505                 510         


Asn Arg Glu His Ile Ile Asp Ala Phe Arg Pro Asp Ile Ser Ser Ser 
        515                 520                 525             


Ser Phe Gln Arg Pro Val Ser Asp Met Asn Ile Ala Ser Gly Cys Pro 
    530                 535                 540                 


Leu Phe Cys Pro Leu Ser Lys Leu Asp Ser Lys Asn Ser Tyr Ile Arg 
545                 550                 555                 560 


Asp Asp Thr Ile Phe Ile Lys Ala Ile Val Asp Leu Thr Gly Leu 
                565                 570                 575 


<210>  76
<211>  482
<212>  PRT
<213>  Branchiostoma floridae

<400>  76

Met Pro Gly Tyr Ser Arg Glu Ile Phe Glu Val Arg Val Glu Asp Lys 
1               5                   10                  15      


Tyr Leu Cys Ser Ala Cys Arg Leu Val Leu Arg Glu Pro Phe Gln Thr 
            20                  25                  30          


Tyr Cys Gly His Arg Tyr Cys Lys Ser Cys Leu Asp Glu Ile Phe Glu 
        35                  40                  45              


Tyr Ala Phe Pro Asp Arg Ala Ile Lys Arg Asp Ile Gly Asp Leu Pro 
    50                  55                  60                  


Val Lys Cys Leu Asn Ala Gly Leu Cys Glu Trp Lys Gly Lys Ala Glu 
65                  70                  75                  80  


Gln Tyr Asp Glu His Gln Glu Thr Cys Glu Phe Val Leu Ile Pro Cys 
                85                  90                  95      


Pro Lys Gln Gly Cys Gly Lys Gln Val Met Arg Met Asp Leu Ala Ala 
            100                 105                 110         


His Leu Glu Lys Glu Cys Ala Val Arg Gln Val Lys Cys Lys Tyr Cys 
        115                 120                 125             


Ala Gln Glu Ile Leu Leu Lys Asp Glu Lys Asp His Leu Phe Ile Cys 
    130                 135                 140                 


Pro Gln Val Pro Val Asn Cys Asp Phe Cys Gly Lys Lys Lys Ile Pro 
145                 150                 155                 160 


Arg Ala Gln Leu Gln Gln His Gln Asp Glu Asp Thr Gly Asp Cys Lys 
                165                 170                 175     


Arg Leu Lys Val Ala Cys Arg Phe Ala Lys Val Gly Cys Gln Ala Lys 
            180                 185                 190         


Leu Glu Arg Glu Lys Leu Asn Asp His Ile Ala Lys Asn His Val Asp 
        195                 200                 205             


His Leu Asn His Leu Leu Asp Asn His Leu Thr Leu Met Glu Lys Val 
    210                 215                 220                 


Asn Leu Leu Lys Gln Asn Pro Gln Ala Gln His Met Gln Gln Ala Met 
225                 230                 235                 240 


Ala Ser Lys Gln Glu Glu Met Arg His Lys Tyr Val Ala Met Glu Thr 
                245                 250                 255     


Arg Val Ala Thr Phe Glu Gly Ile Val Ala Val Leu Asn Arg Glu Ile 
            260                 265                 270         


Glu Lys Cys Ser Ala Thr Ile Glu Ala Tyr Glu Arg Gln Arg Arg Gln 
        275                 280                 285             


Asp Arg Glu Ile Ile Glu Ser Ile Glu Arg Lys Met Lys Ser Gln Glu 
    290                 295                 300                 


Arg Ile Ile Ala Leu Lys Asp Val Ala Leu Ala Glu Gln Asp Leu Arg 
305                 310                 315                 320 


Ile Thr Ser Leu Glu Met Thr Ser Tyr Asp Ala Thr Leu Leu Trp Lys 
                325                 330                 335     


Ile Gln Asp Phe Thr Arg Lys Arg His Asp Ala Ile Thr Gly Lys Thr 
            340                 345                 350         


Thr Ser Ile Tyr Ser Pro Cys Phe Tyr Thr Ser Arg Thr Gly Tyr Lys 
        355                 360                 365             


Met Cys Ala Arg Ile Tyr Leu Asn Gly Asp Gly Met Gly Lys Gly Ser 
    370                 375                 380                 


His Ile Ser Leu Phe Phe Val Leu Met Arg Gly His Phe Asp Gly Leu 
385                 390                 395                 400 


Leu Arg Trp Pro Phe Arg Gln Lys Val Thr Phe Met Leu Leu Asp Gln 
                405                 410                 415     


Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg Pro Asp Pro Thr Ser 
            420                 425                 430         


Ser Ser Phe Lys Arg Pro Thr Ser Asp Met Asn Ile Ala Ser Gly Cys 
        435                 440                 445             


Pro Leu Phe Met Pro Leu Ser Gln Leu Glu Ser Thr Arg His Ala Tyr 
    450                 455                 460                 


Val Arg Asp Asp Ala Ile Phe Leu Lys Ile Ile Val Asp Thr Ser Asp 
465                 470                 475                 480 


Leu Asn 
        


<210>  77
<211>  498
<212>  PRT
<213>  Amphimedon queenslandica

<400>  77

Met Pro Gly Tyr Asp Leu Lys Ile Asn Gly Glu Tyr Ala Arg Ile Glu 
1               5                   10                  15      


Ser Leu Gln Cys Ser Ser Cys Glu Leu Ile Leu Lys Asp Ala Ile Gln 
            20                  25                  30          


Asn Glu Asp Gly Gln Arg Phe Cys Lys Ser Cys Trp Glu Glu Ala Ile 
        35                  40                  45              


Ser Ser Ser Ser Lys Ala Gln Lys Leu Gly Ile Asn Pro Lys Glu Glu 
    50                  55                  60                  


Ile His Pro Asp Ile Ala Val Arg Arg Glu Ile Asp Arg Leu Pro Val 
65                  70                  75                  80  


Leu Cys Glu Asn Tyr Glu Asn Gly Cys Asp Trp Thr Gly Lys Leu Lys 
                85                  90                  95      


Asp His Glu His Asp His Lys Ala Ile Cys Glu Tyr Lys Thr Met Arg 
            100                 105                 110         


Cys Pro Leu Gly Cys Gly Lys Arg Ile Pro Leu Gly Lys Leu Arg Lys 
        115                 120                 125             


His Glu Lys Glu Glu Cys Pro Phe Arg Gln Val Arg Cys Gln Tyr Cys 
    130                 135                 140                 


Arg Ser Glu Leu Leu Ala Gly Asp Tyr Asp Asp His Leu Leu Asn Cys 
145                 150                 155                 160 


Pro Asn Ala Pro Tyr Thr Cys Gly His Cys His Thr Glu Met Pro Arg 
                165                 170                 175     


Ser Glu Ile His Lys Ser Leu Ser Lys His Pro Asn Pro Ile Ser His 
            180                 185                 190         


Leu Glu Asn Asp Gln Val Phe Met His Leu Gln Met Leu Gly Leu Ala 
        195                 200                 205             


Met Lys Arg Leu Glu Thr His Phe Asn Val Ala Leu Lys Asp Ile Lys 
    210                 215                 220                 


Lys Glu Leu Thr Glu Ile Asp Glu Ser Asn Ser Lys Phe Lys Asp Lys 
225                 230                 235                 240 


Met Ile Asn Glu Ser Ser Ser Leu Thr Lys Gln Val Lys Gln Leu Glu 
                245                 250                 255     


Glu Arg Leu Lys Gly Glu Pro Ser Asn Arg Ile Ile Ile Glu Leu Gln 
            260                 265                 270         


Gly Glu Val Thr Lys Leu Ala Glu Arg Val Ser Lys Val Glu Ser Gly 
        275                 280                 285             


Ala Ser Tyr Arg Pro Leu Asn Gln Gly Tyr Asp Asp Met Ser Thr Ser 
    290                 295                 300                 


Asp Ser Lys Met Gly Gly Ser Ile Glu His Lys Leu Ala Glu Gln Glu 
305                 310                 315                 320 


Arg Thr Ser Gly Met Leu Lys Val His Leu Ser Glu Leu Glu Leu Gln 
                325                 330                 335     


Leu Gln Ala Ser Leu Ala Ser Thr Tyr Asn Gly Ser Phe Leu Trp Arg 
            340                 345                 350         


Ile Pro Asp Val Lys Arg Arg Lys Arg Asp Ala Ile Glu Gly Lys Ile 
        355                 360                 365             


Thr Ser Ile Tyr Ser Pro Pro Phe Tyr Thr Gly Arg Asn Gly Tyr Lys 
    370                 375                 380                 


Met Cys Ile Arg Ala Tyr Leu Asn Gly Asp Gly Ile Gly Tyr Asn Thr 
385                 390                 395                 400 


His Leu Ser Ile Phe Phe Val Leu Met Lys Gly Glu Tyr Asp Pro Leu 
                405                 410                 415     


Leu Lys Trp Pro Phe Asp Phe Lys Val Ser Leu Ile Met Val Asp Gln 
            420                 425                 430         


Asp His Lys Arg His Ile Val Gln Thr Phe Lys Pro Ser Pro Ser Ser 
        435                 440                 445             


Ser Ser Phe Gln Arg Pro Lys Ser Asp Met Asn Ile Ala Ser Gly Cys 
    450                 455                 460                 


Pro Lys Phe Ala Glu Leu Lys Ile Leu Asp Asn Glu Ser Tyr Val Lys 
465                 470                 475                 480 


Glu Asp Val Met Tyr Val Lys Ala Ile Val Asp Thr Thr Arg Ile Phe 
                485                 490                 495     


His Pro 
        


<210>  78
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Homo sapiens

<400>  78

Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Mus musculus

<400>  79

Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Gallus gallus

<400>  80

Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Dario rerio

<400>  81

Ser Ser Ser Phe Arg Arg Pro Thr Gly Glu 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Eptatretus brugeri

<400>  82

Ser Ser Ser Phe Lys Arg Pro Thr Ser Glu 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Pinctada fucata

<400>  83

Ser Ser Ser Phe Arg Lys Pro Thr Thr Glu 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Strongylocentrotus purpuratus

<400>  84

Ser Ser Ser Phe Gln Arg Pro Thr Ser Asn 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAF3 Serine Tongs derived from Nematostella vectensis

<400>  85

Ser Ser Ser Phe Lys Arg Pro Thr Ser Asn 
1               5                   10  


<210>  86
<211>  568
<212>  PRT
<213>  homo sapiens

<400>  86

Met Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe 
            20                  25                  30          


Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu 
        35                  40                  45              


Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys 
    50                  55                  60                  


Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val 
                85                  90                  95      


Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala 
            100                 105                 110         


Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu 
        115                 120                 125             


Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu 
    130                 135                 140                 


Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys 
145                 150                 155                 160 


Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr 
                165                 170                 175     


Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Lys His 
            180                 185                 190         


Glu Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys 
        195                 200                 205             


Ser Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu 
    210                 215                 220                 


Cys Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val 
225                 230                 235                 240 


Phe Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala 
                245                 250                 255     


Val Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys 
            260                 265                 270         


Lys Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile 
        275                 280                 285             


Gln Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg 
    290                 295                 300                 


Gln Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln 
305                 310                 315                 320 


Arg Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu 
                325                 330                 335     


Ile Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser 
            340                 345                 350         


Ser Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp 
        355                 360                 365             


Lys Ser Ala Gly Gln Val Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln 
    370                 375                 380                 


Leu Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala 
385                 390                 395                 400 


Asp Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly 
                405                 410                 415     


Val Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala 
            420                 425                 430         


Val Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly 
        435                 440                 445             


Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly 
    450                 455                 460                 


Met Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly 
465                 470                 475                 480 


Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu 
                485                 490                 495     


Met Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe 
            500                 505                 510         


Lys Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met 
        515                 520                 525             


Asn Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu 
    530                 535                 540                 


Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val 
545                 550                 555                 560 


Asp Thr Ser Asp Leu Pro Asp Pro 
                565             


<210>  87
<211>  567
<212>  PRT
<213>  mus musculus

<400>  87

Met Glu Ser Ser Lys Lys Met Asp Ala Ala Gly Thr Leu Gln Pro Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu Gln Pro Asp Arg Gly Ala Gly Ser Val Leu Val 
            20                  25                  30          


Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu Asp 
        35                  40                  45              


Lys Tyr Lys Cys Glu Lys Cys Arg Leu Val Leu Cys Asn Pro Lys Gln 
    50                  55                  60                  


Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu 
65                  70                  75                  80  


Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Ile Lys 
                85                  90                  95      


Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala Leu 
            100                 105                 110         


Gln Val Tyr Cys Arg Asn Glu Gly Arg Gly Cys Ala Glu Gln Leu Thr 
        115                 120                 125             


Leu Gly His Leu Leu Val His Leu Lys Asn Glu Cys Gln Phe Glu Glu 
    130                 135                 140                 


Leu Pro Cys Leu Arg Ala Asp Cys Lys Glu Lys Val Leu Arg Lys Asp 
145                 150                 155                 160 


Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr Cys 
                165                 170                 175     


Ser His Cys Lys Ser Gln Val Pro Met Ile Lys Leu Gln Lys His Glu 
            180                 185                 190         


Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys Ser 
        195                 200                 205             


Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu Cys 
    210                 215                 220                 


Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val Phe 
225                 230                 235                 240 


Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala Val 
                245                 250                 255     


Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys Lys 
            260                 265                 270         


Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile Gln 
        275                 280                 285             


Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg Gln 
    290                 295                 300                 


Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln Arg 
305                 310                 315                 320 


Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu Ile 
                325                 330                 335     


Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser Ser 
            340                 345                 350         


Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp Lys 
        355                 360                 365             


Ser Ala Gly Gln Ala Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln Leu 
    370                 375                 380                 


Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala Asp 
385                 390                 395                 400 


Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly Val 
                405                 410                 415     


Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala Val 
            420                 425                 430         


Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr 
        435                 440                 445             


Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met 
    450                 455                 460                 


Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu 
465                 470                 475                 480 


Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu Met 
                485                 490                 495     


Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe Lys 
            500                 505                 510         


Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met Asn 
        515                 520                 525             


Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu Asn 
    530                 535                 540                 


Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val Asp 
545                 550                 555                 560 


Thr Ser Asp Leu Pro Asp Pro 
                565         


<210>  88
<211>  464
<212>  PRT
<213>  gallus gallus

<400>  88

Met Asp Thr Ser Lys Lys Thr Glu Pro Pro Leu Ser Val Glu Met Val 
1               5                   10                  15      


Gln Gln Arg Ala Asn Pro Asp Arg Ser Pro Ser Ala Ser Ile Tyr Val 
            20                  25                  30          


Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Asn Ala Val Glu Asp 
        35                  40                  45              


Lys Tyr Lys Cys Glu Lys Cys His Phe Ile Leu Cys Asn Pro Lys Gln 
    50                  55                  60                  


Thr Glu Cys Gly His Arg Phe Cys Glu Thr Cys Met Asn Ala Leu Leu 
65                  70                  75                  80  


Ser Thr Pro Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val Lys 
                85                  90                  95      


Asp Lys Val Phe Lys Asp Asn Cys Cys Arg Arg Glu Leu Leu Ala Leu 
            100                 105                 110         


Gln Ile Tyr Cys Arg Asn Glu Asn Lys Gly Cys Lys Glu Gln Leu Ser 
        115                 120                 125             


Leu Gly Gln Leu Leu Met His Leu Lys Thr Asp Cys Gln Phe Glu Glu 
    130                 135                 140                 


Leu Pro Cys Pro Arg Ala Asp Cys Lys Glu Lys Ile Leu Arg Lys Asp 
145                 150                 155                 160 


Leu Pro Asp His Val Glu Lys Thr Cys Lys Tyr Arg Glu Thr Thr Cys 
                165                 170                 175     


Lys Tyr Cys Lys Ser Gln Val Pro Met Ile Met Leu Gln Lys His Glu 
            180                 185                 190         


Asp Thr Asp Cys Pro Cys Val Met Val Ser Cys Pro His Lys Cys Ser 
        195                 200                 205             


Val Lys Thr Leu Met Arg Ser Glu Arg Val Ile Asp Ser Gln Ala Glu 
    210                 215                 220                 


Lys Leu Lys Glu Leu Asp Lys Glu Ile Arg Pro Phe Arg Gln Asn Trp 
225                 230                 235                 240 


Glu Glu Ala Asp Ser Met Lys Ser Ser Val Glu Ser Leu Gln Asn Arg 
                245                 250                 255     


Val Thr Glu Leu Glu Ser Val Asp Lys Thr Ala Gly Gln Gly Ala Arg 
            260                 265                 270         


Asn Thr Ser Met Leu Glu Thr Gln Leu Ser Arg His Asp Gln Met Leu 
        275                 280                 285             


Ser Val His Asp Ile Arg Leu Ala Asp Met Asp Leu Arg Phe Gln Val 
    290                 295                 300                 


Leu Glu Thr Ala Ser Tyr Asn Gly Val Leu Ile Trp Lys Ile Arg Asp 
305                 310                 315                 320 


Tyr Lys Arg Arg Lys Gln Glu Ala Val Met Gly Lys Thr Leu Ser Leu 
                325                 330                 335     


Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met Cys Ala 
            340                 345                 350         


Arg Val Tyr Leu Asn Gly Asp Gly Met Gly Lys Gly Thr His Leu Ser 
        355                 360                 365             


Leu Phe Phe Val Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu Pro Trp 
    370                 375                 380                 


Pro Phe Lys Gln Lys Val Thr Leu Met Leu Met Asp Gln Gly Pro Ser 
385                 390                 395                 400 


Arg Arg His Leu Gly Asp Ala Phe Lys Pro Asp Pro Asn Ser Ser Ser 
                405                 410                 415     


Phe Lys Lys Pro Thr Gly Glu Met Asn Ile Ala Ser Gly Cys Pro Val 
            420                 425                 430         


Phe Val Ala Gln Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys Asp Asp 
        435                 440                 445             


Thr Ile Phe Ile Lys Val Ile Val Asp Thr Ser Asp Leu Pro Asp Pro 
    450                 455                 460                 


<210>  89
<211>  573
<212>  PRT
<213>  danio rerio

<400>  89

Met Ser Ala Gly Arg Asn Val Glu Gln Gln Ile Pro Leu Gln Gln Arg 
1               5                   10                  15      


Pro Pro Ser Leu Ala Met Pro Ser Met Ala Gln Arg Pro Arg Pro Glu 
            20                  25                  30          


Pro Gly Phe Ser Pro Leu His Gly Gly Phe Arg Asp His Phe Val Thr 
        35                  40                  45              


Thr Pro Glu Pro Lys Tyr Cys Cys Glu Thr Cys Arg Leu Val Leu Cys 
    50                  55                  60                  


Asn Pro Arg Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Ile 
65                  70                  75                  80  


Asn Glu Leu Leu Ser Lys Pro Asn Pro Val Cys Pro Ala Asp Leu Leu 
                85                  90                  95      


Pro Leu Phe Glu Asp Lys Ile Phe Arg Asp Val Cys Cys Asn Arg Glu 
            100                 105                 110         


Ile Met Ala Leu Lys Val Tyr Cys Arg Ser Glu Lys Asn Gly Cys Lys 
        115                 120                 125             


Glu Gln Met Cys Leu Gln Gln Val Met Glu His Leu Val Ile Cys Pro 
    130                 135                 140                 


Tyr Phe Glu Val Pro Cys Pro Leu Gly Lys Cys Lys Glu Lys Met Met 
145                 150                 155                 160 


Arg Lys Asp Met Pro Glu His Leu Ser Arg Lys Cys Lys His Arg Glu 
                165                 170                 175     


Val Thr Cys Glu Phe Cys Ser Leu Lys Met Ala Leu Thr Glu Leu Gln 
            180                 185                 190         


Lys His Lys Glu Thr Val Cys Pro Ala Phe Pro Val Ala Cys Pro Asn 
        195                 200                 205             


His Cys Ser Phe Ser Ser Ile Leu Arg Ser Glu Leu Ser Ser His Gln 
    210                 215                 220                 


His Asp Cys Pro Lys Ala Gln Val Thr Cys Ser Phe Ile Arg Tyr Gly 
225                 230                 235                 240 


Cys Ser Tyr Lys Gly Leu Asn Gln Glu Met Arg Glu His Glu Ser Ser 
                245                 250                 255     


Phe Ala Ser Glu His Leu Arg Met Met Ala Val Arg Asn Thr Thr Leu 
            260                 265                 270         


Glu Ala Lys Val Glu Asp Val Lys Ser Glu Leu Met Glu Arg Tyr Lys 
        275                 280                 285             


Val Leu Pro Ser Leu Ser Ser Arg Leu Ala Glu Val Glu Arg Gln Tyr 
    290                 295                 300                 


Glu Glu Met Arg Glu Lys Asn Arg Gln Leu Glu Gln Lys Leu Val Ser 
305                 310                 315                 320 


Met Gln Met Leu Met Ser Ser His Ser Glu Lys Leu Leu Glu Val Glu 
                325                 330                 335     


Met Glu Leu Arg Glu Leu Arg Pro Leu Arg Ala Met Arg Glu Glu Val 
            340                 345                 350         


Glu Thr Leu Arg Gly Ser Val Glu Ser Met Arg Ser Met Val Ser Ser 
        355                 360                 365             


Leu Asp Ser Ser Cys Val Asn Ser Ala Ser Gly Ser His Thr Leu Ala 
    370                 375                 380                 


Ser Leu Glu Gln Gln Leu Thr Arg His Asp Asp Leu Met Ser Val His 
385                 390                 395                 400 


Asp Val Arg Leu Ala Glu Met Asp Leu Lys Leu Gln Val Leu Glu Thr 
                405                 410                 415     


Ala Ser Phe Asn Gly Thr Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg 
            420                 425                 430         


Arg Lys Gln Glu Ala Val Val Ser Lys Thr Leu Ser Leu Tyr Ser Gln 
        435                 440                 445             


Pro Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr 
    450                 455                 460                 


Leu Asn Gly Asp Gly Met Gly Lys Gly Thr His Leu Ser Leu Phe Phe 
465                 470                 475                 480 


Val Val Met Arg Gly Glu Tyr Asp Ala Leu Leu Gln Trp Pro Phe Lys 
                485                 490                 495     


Gln Lys Val Thr Leu Met Leu Met Asp Gln Gly Pro Ala Arg Lys His 
            500                 505                 510         


Leu Gly Asp Ala Phe Lys Pro Asp Pro Ser Ser Ser Ser Phe Arg Arg 
        515                 520                 525             


Pro Thr Gly Glu Met Asn Ile Ala Ser Gly Cys Pro Leu Phe Val Ala 
    530                 535                 540                 


Gln Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe 
545                 550                 555                 560 


Ile Lys Val Thr Val Asp Thr Ser Asp Leu Pro Asp Pro 
                565                 570             


<210>  90
<211>  561
<212>  PRT
<213>  Eptatretus burgeri

<400>  90

Met Val Pro Ala Leu Gly Ile Cys Phe Pro Lys Val Pro Leu Arg Ser 
1               5                   10                  15      


Arg Pro Leu Gln Ile Ser Trp Pro Pro Leu Arg Gly Tyr Ala Tyr Asn 
            20                  25                  30          


Phe Val Glu Thr Pro Pro Ala Lys Tyr Cys Cys Gly Val Cys Ser Leu 
        35                  40                  45              


Pro Leu Arg Glu Ala His Gln Thr Gly Cys Gly His Arg Leu Cys Arg 
    50                  55                  60                  


Ser Cys Ala Asp Gly Leu Leu Thr Glu Thr Asn Pro Gln Cys Pro Glu 
65                  70                  75                  80  


Cys Ser Glu Pro Leu Asp Gln Lys Gln Val Tyr Arg Asp Thr Cys Cys 
                85                  90                  95      


Asn Arg Glu Ile Leu Asn Leu His Val Phe Cys Pro Asn Glu Ala Ser 
            100                 105                 110         


Gly Cys Cys Glu Thr Met Val Leu His Lys Leu Leu Val His Leu Asp 
        115                 120                 125             


Thr Cys Pro Tyr Glu Leu Val Ala Cys His Asn Asp Ala Cys Ser Met 
    130                 135                 140                 


His Leu Ala Arg Leu Tyr Met Pro Gln His His Gly Thr Cys Pro Phe 
145                 150                 155                 160 


Arg Leu Glu Phe Cys Lys Phe Cys Ser Ala Pro Val Pro Cys Val Gln 
                165                 170                 175     


Leu Glu Glu His Lys Gln Thr Cys Pro Lys Tyr Leu Leu Pro Cys Pro 
            180                 185                 190         


Asn Asn Cys Asp Glu His Gly Ile Pro Arg Asn Glu Leu Glu Lys His 
        195                 200                 205             


Leu Val Gln Cys Ala Leu Thr Glu Gln Pro Cys Ser Phe His Arg Phe 
    210                 215                 220                 


Gly Cys Asp Phe Lys Ala Cys Gly Lys Gly Val Ser Glu His Glu Ala 
225                 230                 235                 240 


Gly Ser Val Pro Gln His Leu Leu Leu Val Leu Arg Lys His Thr Glu 
                245                 250                 255     


Leu Gln Glu Thr Leu Gly Gln Val Gln Gly Glu Leu Glu Gln Lys Ala 
            260                 265                 270         


Ser Val Phe Glu Gln Met Gln Leu Arg Leu Glu Arg Ala Glu Arg Asp 
        275                 280                 285             


Ala Glu His Trp Gly Lys Leu Val Ser Lys Asn Glu Ala Ser Leu Thr 
    290                 295                 300                 


Ser Thr Met Glu Lys Val Thr Ser Gln Thr Lys Arg Met Gln Val Leu 
305                 310                 315                 320 


Glu Lys Leu Trp Glu Ser Ser Asn Gly Leu Ser Thr Met Ser Leu Glu 
                325                 330                 335     


Ser Ser Arg Ser Arg Glu Cys His Asp Asn Leu Lys Gly Val Arg Gln 
            340                 345                 350         


Met Leu Glu Val Val Lys Thr Arg Leu Ser Thr Leu Glu Ser Leu Gln 
        355                 360                 365             


Ser Thr Val Gly Thr Met Glu Lys Thr Leu Gln Thr His Glu Ser Leu 
    370                 375                 380                 


Leu Pro Val His Thr Gln Arg Leu Ala Asp Thr Asp Leu Arg Phe Gln 
385                 390                 395                 400 


Leu Leu Glu Thr Val Ser Cys Ser Gly Arg Leu Val Trp Lys Leu Thr 
                405                 410                 415     


Asp Tyr Ala Gln Arg Lys Gln Asp Ala Thr Thr Gly Ile Thr Pro Ser 
            420                 425                 430         


Leu Tyr Ser Gln Pro Phe Tyr Thr Thr Thr Phe Gly Tyr Lys Met Cys 
        435                 440                 445             


Ala Arg Val Tyr Leu Asn Gly Asp Gly Val Gly Arg Gly Thr His Leu 
    450                 455                 460                 


Ser Leu Phe Phe Val Val Met Arg Gly Glu Tyr Asp Thr Ile Leu Ser 
465                 470                 475                 480 


Trp Pro Phe Arg Gln Arg Val Thr Leu Met Leu Leu Asp Gln Gly Pro 
                485                 490                 495     


Gly Arg Lys His Leu Ser Asp Thr Phe Lys Pro Asp Pro Thr Ser Ser 
            500                 505                 510         


Ser Phe Lys Arg Pro Thr Ser Glu Met Asn Val Ala Ser Gly Cys Pro 
        515                 520                 525             


Met Phe Val Ser His Gly Val Leu Glu Ser Arg Thr Tyr Leu Lys Asp 
    530                 535                 540                 


Asp Ser Ile Phe Leu Ser Ile Val Val Asp Arg Thr Gly Leu Asp Asp 
545                 550                 555                 560 


Leu 
    


<210>  91
<211>  540
<212>  PRT
<213>  pinctada fucata

<400>  91

Met Cys Lys Ile Cys Asn Asp Val Leu Arg Asp Ala Val Gln Thr Phe 
1               5                   10                  15      


Cys Gly His Arg Ile Cys Leu Gln Cys Ile Asp Gln Ala Leu Gln Gly 
            20                  25                  30          


Arg Glu Ser Ile Pro Cys Pro Ala Lys Glu Glu Gly Cys Val Asp Leu 
        35                  40                  45              


Lys Arg Glu Glu Ile Asn Arg Asp Ser Ser Ala Arg Arg Glu Val Arg 
    50                  55                  60                  


Ala Leu Asp Val Phe Cys Pro Phe Glu Asp Gly Gly Cys Lys Lys Thr 
65                  70                  75                  80  


Leu Gln Trp Lys Asp Leu Gln Thr His Glu Glu Thr Cys Glu Phe Arg 
                85                  90                  95      


Pro Val Pro Cys Pro Asn Tyr Leu His Gly Cys Glu Val Ile Ile Ser 
            100                 105                 110         


Tyr Lys Asp Val Asp Glu His Leu Lys Glu Cys Pro Tyr Arg Pro Tyr 
        115                 120                 125             


Arg Cys Gln Phe Cys Asn Gln Glu Val Pro Leu Ala Leu Lys Gln Gln 
    130                 135                 140                 


His Glu Thr Glu Thr Cys Pro Arg Ile Pro Ile Pro Cys Arg Tyr Glu 
145                 150                 155                 160 


Cys Gly Ile Asn Pro Leu Pro Arg Glu Glu Leu Glu Ala His Leu Ile 
                165                 170                 175     


Thr Cys Pro Lys Arg Pro Gln Arg Cys Arg Tyr His Ser Val Gly Cys 
            180                 185                 190         


Thr Phe Glu Gly Thr Ser Glu Glu Val Gln Gln His Glu Arg Asp Asp 
        195                 200                 205             


Thr Asp Arg His Leu Glu Leu Ile Thr Met Tyr Thr Ala Asn Met Asp 
    210                 215                 220                 


Leu Gln Ser Leu Glu Val Arg Arg Glu Leu Gln Asp Met Ser Leu Glu 
225                 230                 235                 240 


Arg Asp Asn Ser Arg Arg Leu Leu Asp Asp Val Ser Arg Gln Met Ala 
                245                 250                 255     


Glu Ile Lys Arg Ser Met Asp Asp Met Lys Ile Gln Val Arg Asp Val 
            260                 265                 270         


Lys Leu Lys Ile Val Ser Gln Thr Glu Arg Ile Ile His Val Glu Arg 
        275                 280                 285             


Lys Val Glu Asp Leu Ala Lys Lys Asp Ser Val Asp Arg His Ala Arg 
    290                 295                 300                 


Asp Leu Gln Val Ile Arg Glu Thr Gln Ala Ser Met Ser Glu Arg Ile 
305                 310                 315                 320 


Arg Gln Leu Glu Gly Arg Ala Pro Ser Gln Gly Asn Pro Ala Val Pro 
                325                 330                 335     


Ala Ile Glu Gly Asn Thr Gly Ser Val Val Pro Gln Val Gln Gln His 
            340                 345                 350         


Glu Arg Gln Leu Gly Leu Gln Asp Ile Arg Leu Ala Glu Leu Asp Leu 
        355                 360                 365             


Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asp Gly Thr Leu Ile Trp 
    370                 375                 380                 


Lys Ile Lys Asp Tyr Ser Arg Arg Lys Gln Asp Ala Ile Thr Gly Arg 
385                 390                 395                 400 


Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Ser Arg Thr Gly Tyr 
                405                 410                 415     


Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met Gly Arg Gly 
            420                 425                 430         


Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu Tyr Asp Thr 
        435                 440                 445             


Leu Leu Ser Trp Pro Phe Lys Gln Lys Val Thr Leu Met Leu Leu Asp 
    450                 455                 460                 


Gln Asp Thr Gly Thr Arg His Leu Ser Asp Thr Phe Arg Pro Asp Pro 
465                 470                 475                 480 


Ser Ser Ser Ser Phe Arg Lys Pro Thr Thr Glu Met Asn Val Ala Ser 
                485                 490                 495     


Gly Cys Pro Leu Phe Val Ser His Ala Val Leu Glu Thr Arg Thr Tyr 
            500                 505                 510         


Val Arg Glu Asp Thr Ile Phe Ile Lys Ile Ile Val Asp Thr Glu Gly 
        515                 520                 525             


Leu Tyr Glu Asp Ser Ile Leu Lys Glu Arg Arg Ser 
    530                 535                 540 


<210>  92
<211>  637
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  92

Met Pro Phe Lys Asp Glu Thr Ala Leu Met Asn Asn Thr His Ser Glu 
1               5                   10                  15      


Ser Val Ile Ile Ile Tyr Leu Ile Leu Gly Ser Leu Ile Asn Phe Thr 
            20                  25                  30          


Thr Leu Ala Ser Leu Phe Ser Lys Ser Gly Ile Leu His Leu Gln Ala 
        35                  40                  45              


Ile Phe Cys His Gln Ala Gln Gln Arg Ser Ala Ser Leu Phe Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Lys Ser Arg His Arg Phe Val Leu Ser Ser Met Ala Glu 
65                  70                  75                  80  


Lys Gly Ala Glu Val Asn Pro Ser Ile Arg Ser Leu Gln Ser Asp Thr 
                85                  90                  95      


Gly Glu Leu Glu Gly Gln Pro Gly Ser Gly Ala Ser Phe Gln Gly Ala 
            100                 105                 110         


Ser Pro Pro Pro Ser Tyr Leu Glu Leu Pro Gly Tyr Ser Thr Asn Ile 
        115                 120                 125             


Phe Lys Ser Pro Pro Ser Glu Gly Tyr Ile Cys Gly Ile Cys Ala Gln 
    130                 135                 140                 


Val Val Arg Trp Pro Val Gln Thr Asp Cys Ala Cys Gly Leu Phe Cys 
145                 150                 155                 160 


His Gly Cys Leu His Arg Tyr Ile Gly Asp Glu Thr Gly Ser Leu Glu 
                165                 170                 175     


Cys Pro Arg Cys His Asp Met Phe Pro Thr Thr Glu Thr Gln Arg Asp 
            180                 185                 190         


Lys Ile Ala His Lys Lys Leu Leu Lys Leu Asp Ile Ile Cys Pro His 
        195                 200                 205             


Gly Cys Gly Thr Asp Met Leu Leu Arg Asp Leu Asp Lys His Glu Glu 
    210                 215                 220                 


Glu Cys Ser Phe Val Ile Ile Glu Cys Ile His Lys His Gln Gly Cys 
225                 230                 235                 240 


Lys Glu Leu Ile Lys Arg Ile Asp Leu Val Lys His Leu Glu Thr Gln 
                245                 250                 255     


Cys Asp Phe Arg Lys Glu Ser Cys Gln His Cys Gly Gln Gln Phe Ile 
            260                 265                 270         


Ala Thr Glu Leu Glu Lys His Glu Lys Val Cys Ala Phe Thr Glu Ser 
        275                 280                 285             


Val Thr Lys Val Leu Met Ala Lys Gly Gly Asp Gly Glu Gly Ala Gly 
    290                 295                 300                 


Ala Ala Ser Glu Gln Val Val Thr Gln Glu Leu Met Lys Thr Val Ala 
305                 310                 315                 320 


Ile Asn Leu Glu Ala Lys Ile Ala Glu Val Arg Arg Ile Met Thr Glu 
                325                 330                 335     


Ile Asp Asn Gln Gly Lys Val Leu Lys Lys Leu Tyr Glu Asp Ser Arg 
            340                 345                 350         


Ala Thr Ile Asn Lys Asn Thr Asp Asn Leu Ser Asp Val Asp Lys Ser 
        355                 360                 365             


Val Lys Gln Leu Gln Lys Met Val Leu Thr Lys Leu Ser Lys Leu Pro 
    370                 375                 380                 


Asp Ile Glu Arg Ser Val Gly Thr Ser Leu Ser Arg Thr Glu Phe Glu 
385                 390                 395                 400 


Ser His Lys Glu Ser Val Gln Gly Ile Arg Glu Glu Leu Asp Ser Gln 
                405                 410                 415     


Lys Thr Arg Ile Ser Glu Leu Glu Asp Gln Ser Ser Ser Gly Thr Ile 
            420                 425                 430         


Gly Gly Ser Gly Glu Gly Ile Ser Lys His Leu Lys Asp Gln Ile Ala 
        435                 440                 445             


Asn Asn Thr Glu Lys Val Asn Tyr Phe Asp Asp Gln Ile Asn Met Tyr 
    450                 455                 460                 


Ser Met Arg Leu Ala Glu His Glu Leu Arg Phe Gln Phe Gln Glu Thr 
465                 470                 475                 480 


Ala Ser Tyr Asp Gly Thr Leu Ile Trp Lys Ile Lys Glu Phe Ala Arg 
                485                 490                 495     


Arg Lys Arg Asp Ala Asp Asn Gly Lys Thr Leu Ser Leu Tyr Ser Gln 
            500                 505                 510         


Pro Phe Tyr Thr Ser Arg Phe Gly Tyr Lys Met Cys Ala Arg Ile Tyr 
        515                 520                 525             


Leu Asn Gly Asp Gly Ile Gly Lys Gly Thr His Val Ser Leu Phe Phe 
    530                 535                 540                 


Val Val Met Lys Gly Asp Tyr Asp Ala Leu Leu Pro Trp Pro Phe Ser 
545                 550                 555                 560 


Gln Lys Val Thr Leu Met Leu Leu Asp Gln Glu Thr Gly Arg Arg His 
                565                 570                 575     


Leu Ser Asp Ser Phe Arg Pro Asp Pro Thr Ser Thr Ser Phe Gln Arg 
            580                 585                 590         


Pro Ser Thr Asn Met Asn Ile Ala Ser Gly Cys Pro Leu Phe Val Ser 
        595                 600                 605             


Gln Ser Val Leu Lys Asp Pro Ala Tyr Val Lys Glu Asp Thr Ile Phe 
    610                 615                 620                 


Ile Lys Val Val Val Asp Thr Thr Asp Leu Tyr Gly Pro 
625                 630                 635         


<210>  93
<211>  531
<212>  PRT
<213>  Nematostella vectensis

<400>  93

Met Gln Asp Glu Gly Phe Gln Thr Glu Leu Phe Val Glu Pro Leu Asp 
1               5                   10                  15      


Pro Lys Tyr Arg Cys Pro Val Cys Gly Asn Ala Leu Lys His Pro Val 
            20                  25                  30          


Gln Thr Pro Cys Gly His Arg Phe Cys Glu Gly Cys Leu Glu Pro Ile 
        35                  40                  45              


Leu Arg Gly Pro Ser Lys Cys Pro Val Asp Gly Glu Glu Leu Lys Ile 
    50                  55                  60                  


Asp Gly Val Phe Lys Asp Val Cys Cys Arg Arg Glu Ile Leu Cys Leu 
65                  70                  75                  80  


Ala Cys Tyr Cys Pro Asn Arg Gln Leu Gly Cys Glu Trp Met Lys Asp 
                85                  90                  95      


Leu Gln Tyr Leu Glu Glu His Arg Ala Asn Cys Glu Tyr Lys Gly Val 
            100                 105                 110         


Gln Cys His Asn Pro Gly Cys Gln Glu Lys Val Ala Lys Arg Asp Leu 
        115                 120                 125             


Glu Ala His Leu Glu Arg Cys Glu Phe Lys Pro Ser Asp Cys Gln Tyr 
    130                 135                 140                 


Cys Leu Gln Arg Ile Pro Ala Ala Ser Met Glu Asp His Leu Gln Thr 
145                 150                 155                 160 


Cys Glu Lys His Pro Val Val Cys Pro His Cys Gly Ala Glu Gly Ile 
                165                 170                 175     


Cys Arg Asp Glu Leu Leu His His Gln Thr Asn Ile Cys Glu Gln Ala 
            180                 185                 190         


Glu Leu Pro Cys Ser Phe Ala Lys His Gly Cys His Phe Lys Gly Thr 
        195                 200                 205             


Arg Glu Ala Leu Glu Thr His Phe Arg Asp Gln Ala Ser Val His Val 
    210                 215                 220                 


Asn Leu Leu Leu Thr Ala Thr Gln Asn Glu Glu Lys Ala Arg Ser Glu 
225                 230                 235                 240 


Met Ala Ala Lys Leu Ser Gln Met Glu Lys Glu Arg Ala Lys Gln Gln 
                245                 250                 255     


Glu Gln Met Tyr Glu Gln Arg Glu Ala Leu Ala Val Ala Asn Gln Asn 
            260                 265                 270         


Leu Arg Thr Tyr Gln Gly Lys Leu Asn Val Ile Glu Arg Ser Val Ala 
        275                 280                 285             


Glu Gln Arg Arg Glu Leu Ala Glu Leu Lys Glu Arg Ile Gln Leu Gln 
    290                 295                 300                 


Glu Val Glu Ala Ala Ile Arg Glu Gln Asp Arg Arg Leu Gly Met Ile 
305                 310                 315                 320 


Glu Asn Glu Ala Ser Arg Gly Ala Ala Pro Ser Ser Gly Pro Gly Ser 
                325                 330                 335     


Met Gly Gly Thr Met Ala Leu Glu Arg Arg Gln Asp Arg Asn Glu His 
            340                 345                 350         


Gln Leu Ala Leu His Asp Ile Gln Leu Ala Glu His Asp Leu Lys Leu 
        355                 360                 365             


Gln Met Leu Glu Ala Thr Ser Tyr Asp Gly Thr Tyr Ile Trp Lys Ile 
    370                 375                 380                 


Asp Glu Tyr Thr Arg Arg Tyr Gln Glu Gly Val Ser Gly Lys Thr Pro 
385                 390                 395                 400 


Ser Ile Tyr Ser Pro Pro Phe Tyr Val Gly Arg Tyr Gly Tyr Lys Ala 
                405                 410                 415     


Cys Ala Arg Val Tyr Pro Asn Gly Asp Gly Met Gly Lys Gly Ser His 
            420                 425                 430         


Leu Ser Leu Phe Phe Val Leu Met Arg Gly Glu Phe Asp Ala Leu Leu 
        435                 440                 445             


Pro Trp Pro Phe Arg Gln Lys Val Thr Phe Lys Leu Leu Asp Gln Asp 
    450                 455                 460                 


Arg Val His Asp Ile Gly Asp Thr Phe Arg Pro Asp Pro Thr Ser Ser 
465                 470                 475                 480 


Ser Phe Lys Arg Pro Thr Ser Asn Met Asn Ile Ala Ser Gly Cys Pro 
                485                 490                 495     


Leu Phe Ile Ser His Thr Asn Leu Gln Thr Arg Ala Tyr Val Arg Asp 
            500                 505                 510         


Asp Thr Met Phe Ile Lys Ile Ala Val Asp Thr Thr Gly Leu Pro Pro 
        515                 520                 525             


Met Gly Phe 
    530     


