                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Becart, Stephane
       Chen, Qiang
       Duffy, Karen
       Ernst, Robin
       Huang, Chichi
       Kuhn, Robert
       Lin-Schmidt, Xiefan
       Luo, Jinquan
       Martinez, Christian
       Obomolova, Galina
       Swiecki, Melissa
       Wu, Sheng-Jiun
       Zhou, Hong
 
<120>  Antibodies specifically binding HLA-DR and their uses

<130>  JBI5078WOPCT

<140>  To be assigned
<141>  2016-12-16

<150>  62/268570
<151>  2015-12-17

<160>  162   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TEV cleavage site

<400>  2

Glu Asp Leu Tyr Phe Gln 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hexahistidine tag

<400>  3

His His His His His His 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  4

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HRV3C cleavage site

<400>  5

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  StrepII tag

<400>  6

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10                  15  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg 
1               5                   10                  


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 
1               5                   10                  15      


Pro 
    


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Val Asn Gln Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val 
1               5                   10              


<210>  12
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered IgG4 Fc

<400>  12

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    210                 215                 220 


<210>  13
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  13

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            180                 185                 190     


<210>  14
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
            20                  25                  30          


His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr 
                85                  90                  95      


Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  15
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr 
            20                  25                  30          


Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  16
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Ser Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


Gln Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu 
            180                 185                 190         


Thr Glu 
        


<210>  17
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
            20                  25                  30          


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
        35                  40                  45              


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
                85                  90                  95      


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
    130                 135                 140                 


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
145                 150                 155                 160 


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
                165                 170                 175     


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  18
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro 
                85                  90                  95      


Lys Glu Pro Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile 
            100                 105                 110         


Asp Lys Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly 
        115                 120                 125             


Glu Leu Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr 
    130                 135                 140                 


Asp Tyr Ser Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala 
145                 150                 155                 160 


Glu Asp Phe Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr 
            180                 185                 190         


Thr Glu 
        


<210>  19
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          


Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              


Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  


Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  


Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg 
                85                  90                  95      


Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu 
            100                 105                 110         


Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg 
        115                 120                 125             


Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn 
    130                 135                 140                 


Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu 
145                 150                 155                 160 


Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr 
                165                 170                 175     


Ser Leu Asp Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser 
            180                 185                 190         


Ala Arg Ser Lys 
        195     


<210>  20
<211>  436
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G89, DR4G90, DR4G92, DR4G93, DR4G99, DR4G102  alpha chain

<400>  20

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
    210                 215                 220                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
225                 230                 235                 240 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                245                 250                 255     


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            260                 265                 270         


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
        275                 280                 285             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    290                 295                 300                 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
305                 310                 315                 320 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                325                 330                 335     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            340                 345                 350         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        355                 360                 365             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    370                 375                 380                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
385                 390                 395                 400 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                405                 410                 415     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys His His 
            420                 425                 430         


His His His His 
        435     


<210>  21
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G89  beta chain

<400>  21

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  22
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G90 bet achain

<400>  22

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg 
            20                  25                  30          


Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu Glu 
    50                  55                  60                  


Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu 
                85                  90                  95      


Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly 
            100                 105                 110         


Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val Thr 
        115                 120                 125             


Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val 
    130                 135                 140                 


Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe 
145                 150                 155                 160 


Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile 
                165                 170                 175     


Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val 
            180                 185                 190         


Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu 
        195                 200                 205             


Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln 
    210                 215                 220                 


Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470             


<210>  23
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G92 beta chain

<400>  23

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 
1               5                   10                  15      


Pro Gly Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly 
            20                  25                  30          


Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe 
        35                  40                  45              


Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His 
    50                  55                  60                  


Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
65                  70                  75                  80  


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
                85                  90                  95      


Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
            100                 105                 110         


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro 
        115                 120                 125             


Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val 
145                 150                 155                 160 


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr 
                165                 170                 175     


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
            180                 185                 190         


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
    210                 215                 220                 


Ser Ala Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 475     


<210>  24
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G93 beta chain

<400>  24

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  25
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G99 beta chain

<400>  25

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg 
            20                  25                  30          


Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu Glu 
    50                  55                  60                  


Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu 
                85                  90                  95      


Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly 
            100                 105                 110         


Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val Thr 
        115                 120                 125             


Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val 
    130                 135                 140                 


Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe 
145                 150                 155                 160 


Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile 
                165                 170                 175     


Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val 
            180                 185                 190         


Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val 
        195                 200                 205             


Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln 
    210                 215                 220                 


Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470             


<210>  26
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G102 beta chain

<400>  26

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 
1               5                   10                  15      


Pro Gly Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly 
            20                  25                  30          


Asp Thr Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe 
        35                  40                  45              


Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn 
    50                  55                  60                  


Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
65                  70                  75                  80  


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
                85                  90                  95      


Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
            100                 105                 110         


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro 
        115                 120                 125             


Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val 
145                 150                 155                 160 


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr 
                165                 170                 175     


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
            180                 185                 190         


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
    210                 215                 220                 


Ser Ala Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 475     


<210>  27
<211>  440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G111, DR4G112 alpha chain

<400>  27

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Ser Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


Gln Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu 
            180                 185                 190         


Thr Glu Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            420                 425                 430         


Gly Ser His His His His His His 
        435                 440 


<210>  28
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G111 beta chain

<400>  28

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Arg Asp Ser 
            20                  25                  30          


Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr Asn Arg Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Glu Val 
                85                  90                  95      


Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu Pro Thr Val 
        115                 120                 125             


Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Pro Leu 
                165                 170                 175     


Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met 
            180                 185                 190         


Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu His Pro Ser 
        195                 200                 205             


Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  29
<211>  440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G113 alpha chain

<400>  29

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro 
                85                  90                  95      


Lys Glu Pro Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile 
            100                 105                 110         


Asp Lys Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly 
        115                 120                 125             


Glu Leu Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr 
    130                 135                 140                 


Asp Tyr Ser Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala 
145                 150                 155                 160 


Glu Asp Phe Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr 
            180                 185                 190         


Thr Glu Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            420                 425                 430         


Gly Ser His His His His His His 
        435                 440 


<210>  30
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G113 beta chain

<400>  30

Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Arg Ala Thr Pro Glu 
            20                  25                  30          


Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn Gly Thr 
        35                  40                  45              


Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe Ala Arg 
    50                  55                  60                  


Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu Gly Arg 
65                  70                  75                  80  


Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu Glu Lys 
                85                  90                  95      


Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu Gly Gly 
            100                 105                 110         


Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val Ser Pro 
        115                 120                 125             


Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys His Val 
    130                 135                 140                 


Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu Asn Gly 
145                 150                 155                 160 


Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg Asn Gly 
                165                 170                 175     


Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln Gln 
            180                 185                 190         


Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp Ser Pro 
        195                 200                 205             


Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser Lys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Trp Ser 
    450                 455                 460                 


His Pro Gln Phe Glu Lys 
465                 470 


<210>  31
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ser His Tyr Gly Ser Thr Leu Ala Phe Ala Ser Trp Gly His Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  32
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Ile Cys Arg Ala Ser Val Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Ile Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  33
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Apolizumab VH

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Lys Trp Ser Gly Gly Ser Thr Glu Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Asp Arg Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Apolizumab VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Asn Ser Tyr 
                85                  90                  95      


Pro Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Arg Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Lys Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ile Thr Ala Val Val Pro Thr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Arg Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Asp Tyr Tyr Cys Gln His Phe Trp Thr Thr Pro Trp 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Thr Trp Thr Thr Cys Gln Ser Ile 
1               5                   


<210>  38
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G112 beta chain

<400>  38

Asn Thr Trp Thr Thr Cys Gln Ser Ile Gly Ser Gly Ser Gly Ser Leu 
1               5                   10                  15      


Glu Val Leu Phe Gln Gly Pro Arg Asp Ser Pro Glu Asp Phe Val Phe 
            20                  25                  30          


Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr Glu Arg Val Arg 
        35                  40                  45              


Leu Val Thr Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr Ala Arg Phe Asp 
    50                  55                  60                  


Ser Asp Val Gly Val Tyr Arg Ala Val Thr Pro Gln Gly Arg Pro Asp 
65                  70                  75                  80  


Ala Glu Tyr Trp Asn Ser Gln Lys Glu Val Leu Glu Gly Thr Arg Ala 
                85                  90                  95      


Glu Leu Asp Thr Val Cys Arg His Asn Tyr Glu Val Ala Phe Arg Gly 
            100                 105                 110         


Ile Leu Gln Arg Arg Val Glu Pro Thr Val Thr Ile Ser Pro Ser Arg 
        115                 120                 125             


Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser Val Thr Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Gln Ile Lys Val Arg Trp Phe Arg Asn Asp Gln Glu 
145                 150                 155                 160 


Glu Thr Ala Gly Val Val Ser Thr Pro Leu Ile Arg Asn Gly Asp Trp 
                165                 170                 175     


Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln Arg Gly Asp 
            180                 185                 190         


Val Tyr Thr Cys His Val Glu His Pro Ser Leu Gln Ser Pro Ile Thr 
        195                 200                 205             


Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser Lys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly Gly Gly Ser Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Trp Ser His Pro 
    450                 455                 460                 


Gln Phe Glu Lys 
465             


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 HCDR1

<400>  39

Ser Tyr Ser Ile His 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30 HCDR1

<400>  40

Ser Asp Trp Ile Gly 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B127 and DR4B98 HCDR1

<400>  41

Ser Tyr Tyr Ile His 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 HCDR2

<400>  42

Tyr Ile Ile Pro Glu Tyr Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30 HCDR2

<400>  43

Ile Ile Arg Pro Gly Asp Ser Asp Thr Tyr Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B127  HCDR2

<400>  44

Gly Ile Arg Pro Ile Ser Gly Asn Ala Glu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B98 HCDR2

<400>  45

Gly Ile Ala Pro Ile Tyr Gly Thr Ala Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 HCDR3

<400>  46

Gly Arg Tyr Tyr Ile Gly Asn Arg Arg Gly Ser Tyr Tyr Gly Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30 HCDR3

<400>  47

Glu Ser Tyr Tyr Tyr Val Gly Val Arg Tyr Arg Pro Ser Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  48
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B127  HCDR3

<400>  48

Asp Ala Ser Tyr Tyr Arg Asn Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B98 HCDR3

<400>  49

Asp Ala Ser Trp Ala Arg Ala Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 LCDR1

<400>  50

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  51
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 LCDR1

<400>  51

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  52
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 LCDR2

<400>  52

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 LCDR2

<400>  53

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 LCDR3

<400>  54

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 LCDR3

<400>  55

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  56
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 VH (DR4H4) amino acid

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ile Pro Glu Tyr Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Tyr Tyr Ile Gly Asn Arg Arg Gly Ser Tyr Tyr Gly 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  57
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30 VH (DR4H39) amino acid

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asp 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Arg Pro Gly Asp Ser Asp Thr Tyr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Tyr Tyr Tyr Val Gly Val Arg Tyr Arg Pro Ser Tyr 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  58
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B127 VH (DR4H7) amino acid

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Arg Pro Ile Ser Gly Asn Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Tyr Tyr Arg Asn Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B98 VH (DR4H50) amino acid

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ala Pro Ile Tyr Gly Thr Ala Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Trp Ala Arg Ala Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  60
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 VL (PH9L1) amino acid

<400>  60

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  61
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 VL

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  63
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  63

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  64
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  65
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210>  66
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Lys Arg Ala Ala 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Arg Arg Ala Ala 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  68

Arg Arg Arg Ala Ala 
1               5   


<210>  69
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G79 HC

<400>  69

Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val Ser Glu Gly Ala 
1               5                   10                  15      


Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val Pro Pro Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys 
        35                  40                  45              


Tyr Thr Ser Ala Ala Thr Leu Val Lys Gly Ile Asn Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr Lys Pro Ser Ala 
65                  70                  75                  80  


His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val Ser Glu Ser Pro 
                85                  90                  95      


Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile 
            100                 105                 110         


Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
        115                 120                 125             


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
145                 150                 155                 160 


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
                165                 170                 175     


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
            180                 185                 190         


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205             


Cys Asp Val Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys Gly Gly Gly Gly Ser His His His His His His 
    450                 455                 460         


<210>  70
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DRG79 LC

<400>  70

Gly Ser Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr 
1               5                   10                  15      


Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr 
        35                  40                  45              


Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly 
    50                  55                  60                  


Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu 
65                  70                  75                  80  


Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser 
                85                  90                  95      


Thr Gly Leu Pro Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ser Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp Cys Gly Phe Thr Gly Gly Gly Gly Ser Glu Asp Leu 
                245                 250                 255     


Tyr Phe Gln Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        355                 360                 365             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
                485                 490                 495     


Asp Asp Asp Lys Trp Ser His Pro Gln Phe Glu Lys 
            500                 505             


<210>  71
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vimentin L70A mutant peptide

<400>  71

Ser Ala Val Arg Ala Arg Ser Ser Val Pro Gly Val Arg 
1               5                   10              


<210>  72
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser 
1               5                   10                  15      


Ala Tyr Gln Asp Lys 
            20      


<210>  73
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR1 genus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Tyr or Asp

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Ser, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be His or Gly

<400>  73

Ser Xaa Xaa Ile Xaa 
1               5   


<210>  74
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR2 genus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Arg or Ala

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Asn or Thr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be Glu or Tyr

<400>  74

Gly Ile Xaa Pro Ile Xaa Gly Xaa Ala Xaa Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 genus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Tyr or Trp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Tyr or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Asn or Ala

<400>  75

Asp Ala Ser Xaa Xaa Arg Xaa Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 genus


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Ser or deleted

<400>  76

Arg Ala Ser Gln Ser Val Ser Ser Xaa Tyr Leu Ala 
1               5                   10          


<210>  77
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (4)..()
<223>  Xaa may be Ser or Asn

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Xaa Ala Ser Xaa Arg Ala Thr 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 genus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Tyr or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be  Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Ser or Trp

<400>  78

Gln Gln Xaa Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  79
<211>  378
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B117 VH (DR4H4) polynucleotide

<400>  79
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttagc agctattcca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggctac attattccgg agtacgggac tgccaattac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcggccga      300

tactatatcg gcaaccgtcg tggcagttat tacggttttg actattgggg ccagggcacc      360

ctggtgaccg tctcgagt                                                    378


<210>  80
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B117 VL (PH9L1) polynucleotide

<400>  80
gagatcgtgc tgacccagag ccccggcacc ctgagcctga gccccggcga gcgggccacc       60

ctgagctgcc gggccagcca gagcgtgagc agcagctacc tggcctggta ccagcagaag      120

cccggccagg ccccccggct gctgatctac ggcgccagca gccgggccac cggcatcccc      180

gaccggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag ccggctggag      240

cccgaggact tcgccgtgta ctactgccag cagtacggca gcagccccct gaccttcggc      300

cagggcacca aggtggagat caag                                             324


<210>  81
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B30 VH (DR4H39) polynucleotide

<400>  81
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gcagcggcta tagctttacc agcgactgga ttggttgggt gcgccagatg      120

ccgggcaaag gcttggaatg gatgggtatc attcgcccgg gcgatagcga tacgtattac      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

ctgcagtgga gcagcctgaa agcgagcgat accgcggtgt attattgcgc gcgtgaatcc      300

tattattacg ttggcgtgcg ttaccgtcca agctattatt tcgattactg gggccagggc      360

accctggtga ccgtctcgag t                                                381


<210>  82
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 VL

<400>  82
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gcgggccacc       60

ctgagctgcc gggccagcca gagcgtgagc agctacctgg cctggtacca gcagaagccc      120

ggccaggccc cccggctgct gatctacgac gccagcaacc gggccaccgg catccccgcc      180

cggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgccagcag cggagcaact ggcccctgac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  83
<211>  363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B127 VH (DR4H7) polynucleotide

<400>  83
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaaa tcctactaca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggtggt attcgtccga tcagcgggaa tgctgagtac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgatgca      300

agctattatc gtaattacgg ttttgactac tggggccagg gcaccctggt gaccgtctcg      360

agt                                                                    363


<210>  84
<211>  452
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 HC amino acid

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ile Pro Glu Tyr Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Tyr Tyr Ile Gly Asn Arg Arg Gly Ser Tyr Tyr Gly 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
    210                 215                 220                 


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala 
225                 230                 235                 240 


Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  85
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30 HC amino acid

<400>  85

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asp 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Arg Pro Gly Asp Ser Asp Thr Tyr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Tyr Tyr Tyr Val Gly Val Arg Tyr Arg Pro Ser Tyr 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    130                 135                 140                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
        195                 200                 205             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
    210                 215                 220                 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
225                 230                 235                 240 


Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  86
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B127 HC amino acid

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Arg Pro Ile Ser Gly Asn Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Tyr Tyr Arg Asn Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  87
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B98 HC amino acid

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ala Pro Ile Tyr Gly Thr Ala Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Trp Ala Arg Ala Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  88
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B117 LC amino acid

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  89
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 LC

<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  90
<211>  1356
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B117 HC

<400>  90
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttagc agctattcca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggctac attattccgg agtacgggac tgccaattac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcggccga      300

tactatatcg gcaaccgtcg tggcagttat tacggttttg actattgggg ccagggcacc      360

ctggtgaccg tctcgagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      420

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      660

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgcc      720

gcagccagct cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacgtgcgt ggtggtggac gtgagcgccg aagaccccga ggtccagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      900

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttc tgcaccagga ctggctgaac      960

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc catcctccat cgagaaaacc     1020

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1200

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  91
<211>  1359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B30 HC

<400>  91
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gcagcggcta tagctttacc agcgactgga ttggttgggt gcgccagatg      120

ccgggcaaag gcttggaatg gatgggtatc attcgcccgg gcgatagcga tacgtattac      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

ctgcagtgga gcagcctgaa agcgagcgat accgcggtgt attattgcgc gcgtgaatcc      300

tattattacg ttggcgtgcg ttaccgtcca agctattatt tcgattactg gggccagggc      360

accctggtga ccgtctcgag tgcctccacc aagggcccat cggtcttccc cctggcgccc      420

tgctccagga gcacctccga gagcacagcc gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgctctga ccagcggcgt gcacaccttc      540

ccagctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcaacttcg gcacccagac ctacacctgc aacgtagatc acaagcccag caacaccaag      660

gtggacaaga cagttgagcg caaatgttgt gtcgagtgcc caccgtgccc agcaccacct      720

gccgcagcca gctcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcg ccgaagaccc cgaggtccag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc acgggaggag      900

cagttcaaca gcacgttccg tgtggtcagc gtcctcaccg ttctgcacca ggactggctg      960

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccatcctc catcgagaaa     1020

accatctcca aaaccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccaca     1200

cctcccatgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  92
<211>  1341
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B127  HC

<400>  92
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaaa tcctactaca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggtggt attcgtccga tcagcgggaa tgctgagtac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgatgca      300

agctattatc gtaattacgg ttttgactac tggggccagg gcaccctggt gaccgtctcg      360

agtgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  93
<211>  1341
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B98 HC

<400>  93
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaag tcctattata ttcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcggt attgcaccaa tttacggcac cgcttactac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgtgatgca      300

agttgggcac gtgcatacgg ttttgattat tggggccagg gcaccctggt gaccgtctcg      360

agtgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  94
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B117 LC

<400>  94
gagatcgtgc tgacccagag ccccggcacc ctgagcctga gccccggcga gcgggccacc       60

ctgagctgcc gggccagcca gagcgtgagc agcagctacc tggcctggta ccagcagaag      120

cccggccagg ccccccggct gctgatctac ggcgccagca gccgggccac cggcatcccc      180

gaccggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag ccggctggag      240

cccgaggact tcgccgtgta ctactgccag cagtacggca gcagccccct gaccttcggc      300

cagggcacca aggtggagat caagcggacc gtggccgccc ccagcgtgtt catcttcccc      360

cccagcgacg agcagctgaa gagcggaacc gcaagcgtgg tgtgcctgct gaacaacttc      420

tacccccggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggagagcg tgaccgagca ggacagcaag gacagcacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcac aaggtgtacg cttgcgaggt gacccaccag      600

ggcctgagca gccccgtgac caagagcttc aaccggggcg agtgc                      645


<210>  95
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B30, DR4B127, DR4B98 LC

<400>  95
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gcgggccacc       60

ctgagctgcc gggccagcca gagcgtgagc agctacctgg cctggtacca gcagaagccc      120

ggccaggccc cccggctgct gatctacgac gccagcaacc gggccaccgg catccccgcc      180

cggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgccagcag cggagcaact ggcccctgac cttcggccag      300

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggaaccgca agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgctt gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cggggcgagt gc                         642


<210>  96
<211>  456
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B391 HC protein

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ile Pro Glu Tyr Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Tyr Tyr Ile Gly Asn Arg Arg Gly Ser Tyr Tyr Gly 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Ala Gly Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Ala Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  97
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B396 HC protein

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asp 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Arg Pro Gly Asp Ser Asp Thr Tyr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Tyr Tyr Tyr Val Gly Val Arg Tyr Arg Pro Ser Tyr 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Ala Ser Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Ala Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  98
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B392 HC protein

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Arg Pro Ile Ser Gly Asn Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Tyr Tyr Arg Asn Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  99
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B401 HC protein

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ala Pro Ile Tyr Gly Thr Ala Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Trp Ala Arg Ala Tyr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  100
<211>  1368
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B391 HC polynucleotide

<400>  100
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttagc agctattcca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggctac attattccgg agtacgggac tgccaattac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcggccga      300

tactatatcg gcaaccgtcg tggcagttat tacggttttg actattgggg ccagggcacc      360

ctggtgaccg tctcgagtgc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagcag caggggcatc ttcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcgc cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccatcctcc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210>  101
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B396 HC polynucleotide

<400>  101
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gcagcggcta tagctttacc agcgactgga ttggttgggt gcgccagatg      120

ccgggcaaag gcttggaatg gatgggtatc attcgcccgg gcgatagcga tacgtattac      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

ctgcagtgga gcagcctgaa agcgagcgat accgcggtgt attattgcgc gcgtgaatcc      300

tattattacg ttggcgtgcg ttaccgtcca agctattatt tcgattactg gggccagggc      360

accctggtga ccgtctcgag tgcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag cagcaggggc atcttcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag cgccgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccatcc     1020

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  102
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B392 HC polynucleotide

<400>  102
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaaa tcctactaca ttcactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggtggt attcgtccga tcagcgggaa tgctgagtac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgatgca      300

agctattatc gtaattacgg ttttgactac tggggccagg gcaccctggt gaccgtctcg      360

agtgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agcagcaggg      720

gcatcttcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agcgccgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccat cctccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  103
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B401 polynucleotide

<400>  103
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaag tcctattata ttcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcggt attgcaccaa tttacggcac cgcttactac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgtgatgca      300

agttgggcac gtgcatacgg ttttgattat tggggccagg gcaccctggt gaccgtctcg      360

agtgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agcagcaggg      720

gcatcttcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agcgccgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccat cctccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met 
1               5                   10                  15  


<210>  105
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Asp Thr Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His 
            20                  25                  30          


Asn Gln Glu Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  106
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
            20                  25                  30          


His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Ile Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr 
                85                  90                  95      


Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  107
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  107

Gly Asp Thr Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His 
            20                  25                  30          


Asn Gln Glu Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  108
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
            20                  25                  30          


Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Ile Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  109
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G143 beta chain

<400>  109

Ser Ala Val Arg Ala Arg Ser Ser Val Pro Gly Val Arg Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg Pro 
            20                  25                  30          


Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn Gly Thr 
        35                  40                  45              


Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu Glu Tyr 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val 
            100                 105                 110         


Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val Thr Val 
        115                 120                 125             


Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile Gln 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro 
            180                 185                 190         


Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Thr 
        195                 200                 205             


Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser 
    210                 215                 220                 


Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 


Trp Ser His Pro Gln Phe Glu Lys 
465                 470         


<210>  110
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G142 beta chain

<400>  110

Ser Ala Val Arg Ala Arg Ser Ser Val Pro Gly Val Arg Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg Pro 
            20                  25                  30          


Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn Gly Thr 
        35                  40                  45              


Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu Glu Asn 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr Gly Val 
            100                 105                 110         


Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val Thr Val 
        115                 120                 125             


Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile His 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro 
            180                 185                 190         


Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr 
        195                 200                 205             


Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser 
    210                 215                 220                 


Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 


Trp Ser His Pro Gln Phe Glu Lys 
465                 470         


<210>  111
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G119 beta chain

<400>  111

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  112
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G117 beta chain

<400>  112

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg 
            20                  25                  30          


Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu Glu 
    50                  55                  60                  


Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu 
                85                  90                  95      


Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr Gly 
            100                 105                 110         


Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val Thr 
        115                 120                 125             


Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val 
    130                 135                 140                 


Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe 
145                 150                 155                 160 


Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile 
                165                 170                 175     


His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val 
            180                 185                 190         


Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val 
        195                 200                 205             


Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln 
    210                 215                 220                 


Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470             


<210>  113
<211>  480
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G110 beta chain

<400>  113

Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser 
1               5                   10                  15      


Ala Tyr Gln Asp Lys Gly Ser Gly Ser Gly Ser Leu Glu Val Leu Phe 
            20                  25                  30          


Gln Gly Pro Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His 
        35                  40                  45              


Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg 
    50                  55                  60                  


Tyr Phe Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly 
65                  70                  75                  80  


Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp 
                85                  90                  95      


Asn Ser Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr 
            100                 105                 110         


Tyr Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg 
        115                 120                 125             


Arg Val Tyr Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu 
    130                 135                 140                 


Gln His His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly 
145                 150                 155                 160 


Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly 
                165                 170                 175     


Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr 
            180                 185                 190         


Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys 
        195                 200                 205             


Gln Val Glu His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg 
    210                 215                 220                 


Ala Arg Ser Glu Ser Ala Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp 
225                 230                 235                 240 


Leu Tyr Phe Gln Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Leu Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 475                 480 


<210>  114
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G104 beta chain

<400>  114

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  115
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G103 beta chain

<400>  115

Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  116
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G101 beta chain

<400>  116

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 
1               5                   10                  15      


Pro Gly Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly 
            20                  25                  30          


Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe 
        35                  40                  45              


Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His 
    50                  55                  60                  


Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
65                  70                  75                  80  


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
                85                  90                  95      


Asp Ile Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
            100                 105                 110         


Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro 
        115                 120                 125             


Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val 
145                 150                 155                 160 


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr 
                165                 170                 175     


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
            180                 185                 190         


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
    210                 215                 220                 


Ser Ala Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 475     


<210>  117
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G101 beta chain

<400>  117

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg 
            20                  25                  30          


Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu Glu 
    50                  55                  60                  


Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu 
                85                  90                  95      


Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly 
            100                 105                 110         


Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val Thr 
        115                 120                 125             


Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val 
    130                 135                 140                 


Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe 
145                 150                 155                 160 


Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile 
                165                 170                 175     


Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val 
            180                 185                 190         


Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu 
        195                 200                 205             


Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln 
    210                 215                 220                 


Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470             


<210>  118
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G97 beta chain

<400>  118

Leu Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr Arg 
            20                  25                  30          


Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu 
    50                  55                  60                  


Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu 
                85                  90                  95      


Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly 
            100                 105                 110         


Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val Thr 
        115                 120                 125             


Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val 
    130                 135                 140                 


Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe 
145                 150                 155                 160 


Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu Ile 
                165                 170                 175     


Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val 
            180                 185                 190         


Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val 
        195                 200                 205             


Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln 
    210                 215                 220                 


Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470             


<210>  119
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G96 beta chain

<400>  119

Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  120
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4G86 beta chain

<400>  120

Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Gly Gly Gly Gly Ser Glu Asp Leu Tyr Phe Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Trp Ser His Pro Gln Phe Glu Lys 
465                 470                 


<210>  121
<211>  363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B98 VH

<400>  121
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcgg cacctttaag tcctattata ttcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcggt attgcaccaa tttacggcac cgcttactac      180

gcgcagaaat ttcagggccg cgtgaccatt accgctgatg aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgtgatgca      300

agttgggcac gtgcatacgg ttttgattat tggggccagg gcaccctggt gaccgtctcg      360

agt                                                                    363


<210>  122
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  122

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 
1               5                   10                  15  


<210>  123
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B78 , DR4B70, DR4B38 HCDR1

<400>  123

Ser Tyr Ala Met Ser 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 HCDR1

<400>  124

Ser Ala Tyr Ile Asn 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B22 HCDR1

<400>  125

Ser Tyr Ala Met Asn 
1               5   


<210>  126
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B78, DR4B70, DR4B38 HCDR2

<400>  126

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 HCDR2

<400>  127

Ile Ile Arg Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B22 HCDR2

<400>  128

Ala Ile Ser Gly Ser Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B78  HCDR3

<400>  129

Asp Gly Gly Tyr Tyr Arg Tyr Val Arg Thr Ile Ser Gly Asp Tyr Ala 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  130
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B70 HCDR3

<400>  130

Asp Ser Ser Tyr Tyr Arg Tyr Ile Gly Arg Tyr Leu Gly Asp Tyr Ala 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  131
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B38 HCDR3

<400>  131

Asp Ser Gly Tyr Tyr Arg Leu Ala Ala Ile Gly Arg Ser Asp Tyr Ala 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  132
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 HCDR3

<400>  132

Asp Gly Tyr Tyr Phe Val Gly Ser Ile Ile Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  133
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B22 HCDR3

<400>  133

Asp Gly Gly Tyr Tyr Arg Tyr Val Tyr Arg Tyr Pro Gly Asp Tyr Ala 
1               5                   10                  15      


Phe Gly Tyr 
            


<210>  134
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 LCDR1

<400>  134

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  135
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 LCDR2

<400>  135

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 LCDR3

<400>  136

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  137
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B78 VH (DR4H62)

<400>  137

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Tyr Arg Tyr Val Arg Thr Ile Ser Gly Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  138
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B70 VH (DR4H29)

<400>  138

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Tyr Tyr Arg Tyr Ile Gly Arg Tyr Leu Gly Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  139
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B38 VH (DR4H56)

<400>  139

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Tyr Tyr Arg Leu Ala Ala Ile Gly Arg Ser Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  140
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 VH (DR4H58)

<400>  140

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asp Ser Ala 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Arg Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Phe Val Gly Ser Ile Ile Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  141
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B22 VH (DR4H16)

<400>  141

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Tyr Arg Tyr Val Tyr Arg Tyr Pro Gly Asp 
            100                 105                 110         


Tyr Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  142
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 VL (PH9L4)

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  143
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B78 VH (DR4H62)

<400>  143
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgatggc      300

ggttattatc gttatgtgcg tacaatcagc ggcgattatg cattcgacta ttggggccag      360

ggcaccctgg tgaccgtctc gagt                                             384


<210>  144
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B70 VH (DR4H29)

<400>  144
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgactcc      300

agctattatc gttacattgg ccgttatctg ggcgactacg cattcgacta ctggggccag      360

ggcaccctgg tgaccgtctc gagt                                             384


<210>  145
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B38 VH (DR4H56)

<400>  145
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgtgactcc      300

ggctattatc gtctggcagc aatcggccgt tctgattacg catttgatta ctggggccag      360

ggcaccctgg tgaccgtctc gagt                                             384


<210>  146
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B33 VH (DR4H58)

<400>  146
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gcagcggcta tagcttcgat agcgcataca ttaattgggt gcgccagatg      120

ccgggcaaag gcttggaatg gatgggtatt attcgtcctg gcgattcccg cacgcgttac      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

ctgcagtgga gcagcctgaa agcgagcgat accgcggtgt attattgcgc gcgtgacggc      300

tattattttg ttggcagcat catctattac ggtatggacg tatggggcca gggcaccctg      360

gtgaccgtct cgagt                                                       375


<210>  147
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B22 VH (DR4H16)

<400>  147
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt taccttttcc tcctatgcaa tgaattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgct attagcggtt ccggtgggta tacaaattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgtgacggt      300

ggttactacc ggtatgtgta ccgttatcca ggcgactatg catttggcta ttggggccag      360

ggcaccctgg tgaccgtctc gagt                                             384


<210>  148
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B33 VL (PH9L4)

<400>  148
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc       60

atcacctgcc gggccagcca gagcatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagc      180

cggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctacagca cccccctgac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  149
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B78 HC

<400>  149

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Tyr Arg Tyr Val Arg Thr Ile Ser Gly Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  150
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B70 HC

<400>  150

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Tyr Tyr Arg Tyr Ile Gly Arg Tyr Leu Gly Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  151
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B38 HC

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Tyr Tyr Arg Leu Ala Ala Ile Gly Arg Ser Asp 
            100                 105                 110         


Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  152
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 HC

<400>  152

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asp Ser Ala 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Arg Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Phe Val Gly Ser Ile Ile Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala 
225                 230                 235                 240 


Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  153
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B22 HC

<400>  153

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Tyr Arg Tyr Val Tyr Arg Tyr Pro Gly Asp 
            100                 105                 110         


Tyr Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  154
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR4B33 LC

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  155
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B78 HC

<400>  155
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgatggc      300

ggttattatc gttatgtgcg tacaatcagc ggcgattatg cattcgacta ttggggccag      360

ggcaccctgg tgaccgtctc gagtgcctcc accaagggcc catcggtctt ccccctggcg      420

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      540

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      660

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      720

cctgccgcag ccagctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gcgccgaaga ccccgaggtc      840

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      900

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttctgca ccaggactgg      960

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccatc ctccatcgag     1020

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  156
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B70 HC

<400>  156
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgactcc      300

agctattatc gttacattgg ccgttatctg ggcgactacg cattcgacta ctggggccag      360

ggcaccctgg tgaccgtctc gagtgcctcc accaagggcc catcggtctt ccccctggcg      420

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      540

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      660

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      720

cctgccgcag ccagctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gcgccgaaga ccccgaggtc      840

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      900

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttctgca ccaggactgg      960

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccatc ctccatcgag     1020

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  157
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B38 HC

<400>  157
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg atcagcggct ccggtggctc cacatattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgtgactcc      300

ggctattatc gtctggcagc aatcggccgt tctgattacg catttgatta ctggggccag      360

ggcaccctgg tgaccgtctc gagtgcctcc accaagggcc catcggtctt ccccctggcg      420

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      540

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      660

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      720

cctgccgcag ccagctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gcgccgaaga ccccgaggtc      840

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      900

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttctgca ccaggactgg      960

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccatc ctccatcgag     1020

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  158
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B33 HC

<400>  158
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gcagcggcta tagcttcgat agcgcataca ttaattgggt gcgccagatg      120

ccgggcaaag gcttggaatg gatgggtatt attcgtcctg gcgattcccg cacgcgttac      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

ctgcagtgga gcagcctgaa agcgagcgat accgcggtgt attattgcgc gcgtgacggc      300

tattattttg ttggcagcat catctattac ggtatggacg tatggggcca gggcaccctg      360

gtgaccgtct cgagtgcctc caccaagggc ccatcggtct tccccctggc gccctgctcc      420

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgct ctgaccagcg gcgtgcacac cttcccagct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcaac      600

ttcggcaccc agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      660

aagacagttg agcgcaaatg ttgtgtcgag tgcccaccgt gcccagcacc acctgccgca      720

gccagctcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca cgtgcgtggt ggtggacgtg agcgccgaag accccgaggt ccagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccacggga ggagcagttc      900

aacagcacgt tccgtgtggt cagcgtcctc accgttctgc accaggactg gctgaacggc      960

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccat cctccatcga gaaaaccatc     1020

tccaaaacca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacacctccc     1200

atgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  159
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B22 HC

<400>  159
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt taccttttcc tcctatgcaa tgaattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgct attagcggtt ccggtgggta tacaaattat      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgtgacggt      300

ggttactacc ggtatgtgta ccgttatcca ggcgactatg catttggcta ttggggccag      360

ggcaccctgg tgaccgtctc gagtgcctcc accaagggcc catcggtctt ccccctggcg      420

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      540

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      660

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      720

cctgccgcag ccagctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gcgccgaaga ccccgaggtc      840

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      900

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttctgca ccaggactgg      960

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccatc ctccatcgag     1020

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  160
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DR4B33 LC

<400>  160
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc       60

atcacctgcc gggccagcca gagcatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagc      180

cggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctacagca cccccctgac cttcggccag      300

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggaaccgca agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgctt gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cggggcgagt gc                         642


<210>  161
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  161

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  162
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


