                         SEQUENCE LISTING

<110>  Kadmon Corporation, LLC
       Lu, Dan
 
<120>  PDGFR Beta Antibody

<130>  163761.49176

<150>  62/268,424
<151>  2015-12-16

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCVD CDR1 Motif


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N or W

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  H or F

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  F or V

<400>  1

Gly Phe Thr Phe Ser Xaa Tyr Xaa Met Xaa 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCVD CDR2 Motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  V or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or W

<400>  2

Xaa Ile Xaa Pro Ser Gly Gly Xaa Thr Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD CDR1 (Kabat)

<400>  3

Asn Tyr His Met Phe 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD CDR1 (Chothia)

<400>  4

Gly Phe Thr Phe Ser Asn Tyr 
1               5           


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD CDR2 (Kabat)

<400>  5

Val Ile Ser Pro Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD CDR2 (Chothia)

<400>  6

Ser Pro Ser Gly Gly Ser 
1               5       


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD CDR3

<400>  7

Phe Asp Gly Asp Tyr Leu Trp Asp Asp Tyr Arg His Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 LCVD CDR1

<400>  8

Arg Ala Ser Gln Ser Val Gly Ser Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 LCVD CDR2

<400>  9

Ala Ala Tyr Ser Leu Gln Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 LCVD CDR3

<400>  10

Gln Gln Leu Asn Phe Tyr Pro Phe Thr 
1               5                   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD CDR1 (Kabat)

<400>  11

Trp Tyr Phe Met Val 
1               5   


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD CDR1 (Chothia)

<400>  12

Gly Phe Thr Phe Ser Trp Tyr 
1               5           


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD CDR2 (Kabat)

<400>  13

Arg Ile Tyr Pro Ser Gly Gly Tyr Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD CDR2 (Kabat)

<400>  14

Tyr Pro Ser Gly Gly Tyr 
1               5       


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD CDR3

<400>  15

Val Ser Phe Arg Pro Lys Thr Tyr Tyr Tyr Gly Ser Gly Ser Leu Thr 
1               5                   10                  15      


Trp Gly Gly Met Asp Val 
            20          


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 LCVD CDR1

<400>  16

Ser Gly Asp Lys Leu Gly Asp Lys Asn Ala Tyr 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 LCVD CDR2

<400>  17

Gln Asn Asn Lys Arg Pro Ser 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 LCVD CDR3

<400>  18

Gln Ala Trp Asp Ser Gly Val Val 
1               5               


<210>  19
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 HCVD

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


His Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Gly Asp Tyr Leu Trp Asp Asp Tyr Arg His Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFH2 LCVD

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Tyr Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Phe Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Thr Val Asp Ile Lys Arg 
            100                 105             


<210>  21
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 HCVD

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Phe Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Tyr Pro Ser Gly Gly Tyr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Phe Arg Pro Lys Thr Tyr Tyr Tyr Gly Ser Gly Ser 
            100                 105                 110         


Leu Thr Trp Gly Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  22
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFF9 LCVD

<400>  22

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Ala Cys Ser Gly Asp Lys Leu Gly Asp Lys Asn Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Gln Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Glu Asn Thr Ala Thr Leu Ser Ile Ser Gly Thr Gln Ala Thr 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Val Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Ile Gly Gln Pro 
            100                 105             


<210>  23
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv H2: anti-PDGFR Beta

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


His Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Gly Asp Tyr Leu Trp Asp Asp Tyr Arg His Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Ser Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Ala Ala Tyr 
        195                 200                 205             


Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Glu 
    210                 215                 220                 


Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Leu Asn Phe Tyr Pro Phe Thr Phe Gly Pro 
                245                 250                 255     


Gly Thr Thr Val Asp Ile Lys 
            260             


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1

<400>  24

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  26
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1A1 HC

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  27
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1A1 LC

<400>  27

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Glu Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Leu Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  28
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1A1HC-scFvH2 (bi-specifc)

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    450                 455                 460                 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
465                 470                 475                 480 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr His Met Phe Trp 
                485                 490                 495     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser 
            500                 505                 510         


Pro Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        515                 520                 525             


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
    530                 535                 540                 


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Phe Asp 
545                 550                 555                 560 


Gly Asp Tyr Leu Trp Asp Asp Tyr Arg His Asp Ala Phe Asp Ile Trp 
                565                 570                 575     


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    610                 615                 620                 


Leu Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
625                 630                 635                 640 


Ala Ser Gln Ser Val Gly Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                645                 650                 655     


Gly Lys Ala Pro Lys Leu Leu Ile Phe Ala Ala Tyr Ser Leu Gln Thr 
            660                 665                 670         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Glu Thr Glu Phe Ser 
        675                 680                 685             


Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    690                 695                 700                 


Gln Gln Leu Asn Phe Tyr Pro Phe Thr Phe Gly Pro Gly Thr Thr Val 
705                 710                 715                 720 


Asp Ile Lys 
            


