                         SEQUENCE LISTING

<110>  AMGEN INC.
       HAMBURGER, Agnes E.
       XU, Cen
       SUN, Hong
       SHIH, Yuan D.
       WEERARATNE, Dohan
 
<120>  PACAP ANTIBODIES AND USES THEREOF

<130>  A-2013-WO-PCT

<150>  62/267,822
<151>  2015-12-15

<160>  127   

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  2
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  3
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  4

Gly Lys Arg Tyr Lys Gln Arg Val Lys Asn Lys 
1               5                   10      


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  5

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr 
1               5                   10              


<210>  6
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  6

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Glu Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Arg Thr Ser Thr Leu Glu Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Ile Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Asp Glu Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala 
    130                 135                 140                 


Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr 
145                 150                 155                 160 


Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala 
                165                 170                 175     


Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln 
            180                 185                 190         


Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr 
        195                 200                 205             


Ser Val Val Gln Ser Phe Ser Arg Lys Asn Cys 
    210                 215                 


<210>  7
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  7

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Ala Phe Ser Asn Asp Tyr 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Cys Ile Phe Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Ala Ile Ser Val Leu Gly Tyr Phe Tyr Ala Ala Tyr Phe 
            100                 105                 110         


Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln 
        115                 120                 125             


Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr 
    130                 135                 140                 


Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val 
                165                 170                 175     


Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser 
    210                 215                 220                 


Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr 
        275                 280                 285             


Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val 
    290                 295                 300                 


Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr 
            340                 345                 350         


Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu 
    370                 375                 380                 


Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr 
                405                 410                 415     


Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  8
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  8

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Gln Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Asp Ser 
            20                  25                  30          


Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Phe Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Ile Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ile Ser Gly Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Asp Glu Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala 
    130                 135                 140                 


Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr 
145                 150                 155                 160 


Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala 
                165                 170                 175     


Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln 
            180                 185                 190         


Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr 
        195                 200                 205             


Ser Val Val Gln Ser Phe Ser Arg Lys Asn Cys 
    210                 215                 


<210>  9
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  9

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Asn Ser Ser Ser 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Phe Thr Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Gln Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Ala Tyr Phe Leu Val Gly Tyr Phe Tyr Ala Thr Tyr Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln 
        115                 120                 125             


Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr 
    130                 135                 140                 


Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val 
                165                 170                 175     


Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser 
    210                 215                 220                 


Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr 
        275                 280                 285             


Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val 
    290                 295                 300                 


Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr 
            340                 345                 350         


Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu 
    370                 375                 380                 


Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr 
                405                 410                 415     


Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  10
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  10

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Glu Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Asp Glu Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala 
    130                 135                 140                 


Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr 
145                 150                 155                 160 


Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala 
                165                 170                 175     


Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln 
            180                 185                 190         


Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr 
        195                 200                 205             


Ser Val Val Gln Ser Phe Ser Arg Lys Asn Cys 
    210                 215                 


<210>  11
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  11

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Phe Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu His Val Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Leu Ser Val Val Gly Tyr Phe Tyr Ala Ala Tyr 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
                165                 170                 175     


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
    210                 215                 220                 


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
        275                 280                 285             


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
            340                 345                 350         


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
        355                 360                 365             


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro 
                405                 410                 415     


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  12
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  12

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Gly Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Arg Asn 
            20                  25                  30          


Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Asn Tyr Gly Thr Arg 
                85                  90                  95      


Arg Asn Asn Tyr Val Phe Pro Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Gly Asp Pro Val Ala Pro Thr Val Leu Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Asp Glu Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys 
    130                 135                 140                 


Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln 
145                 150                 155                 160 


Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys 
                165                 170                 175     


Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn 
            180                 185                 190         


Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val 
        195                 200                 205             


Val Gln Ser Phe Ser Arg Lys Asn Cys 
    210                 215         


<210>  13
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  13

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Pro Gly Trp Ser Asn Gly Phe Ala Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser 
            180                 185                 190         


Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile 
            260                 265                 270         


Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln 
        275                 280                 285             


Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln 
    290                 295                 300                 


Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro 
                325                 330                 335     


Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser 
            340                 345                 350         


Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe 
                405                 410                 415     


Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440 


<210>  14
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  14

Ala Asp Ile Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Asn 
            20                  25                  30          


Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Glu Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp 
65                  70                  75                  80  


Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Asp Tyr Ile 
                85                  90                  95      


Ile Ile Glu Asn Ile Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Asp Pro Val Ala Pro Thr Val Leu Leu Phe Pro Pro Ser Ser Asp Glu 
        115                 120                 125             


Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe 
    130                 135                 140                 


Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr 
145                 150                 155                 160 


Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr 
                165                 170                 175     


Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His 
            180                 185                 190         


Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 
        195                 200                 205             


Ser Phe Ser Arg Lys Asn Cys 
    210                 215 


<210>  15
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  15

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Asn 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Phe Ile Asn Ser Asp Asp Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Phe Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Tyr Asp 
                85                  90                  95      


Trp Asp Tyr Tyr Tyr Ser Arg Leu Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser 
            180                 185                 190         


Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile 
            260                 265                 270         


Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln 
        275                 280                 285             


Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln 
    290                 295                 300                 


Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro 
                325                 330                 335     


Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser 
            340                 345                 350         


Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe 
                405                 410                 415     


Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440 


<210>  16
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  16

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Phe Ser Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Arg Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Gly Ser 
                85                  90                  95      


Ile Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Asp Pro 
            100                 105                 110         


Val Ala Pro Thr Val Leu Leu Phe Pro Pro Ser Ser Asp Glu Val Ala 
        115                 120                 125             


Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro Asp 
    130                 135                 140                 


Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly Ile 
145                 150                 155                 160 


Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys Glu 
            180                 185                 190         


Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser Phe 
        195                 200                 205             


Ser Arg Lys Asn Cys 
    210             


<210>  17
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  17

Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser Leu 
1               5                   10                  15      


Thr Leu Thr Cys Thr Thr Ser Gly Phe Ser Leu Ser Asp Asn Tyr Leu 
            20                  25                  30          


Cys Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val Ala Cys 
        35                  40                  45              


Ile Gly Ile Val Leu Arg Ser Thr Gly Ala Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Glu Gly Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Thr 
65                  70                  75                  80  


Leu Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Leu Asp Leu Gly Tyr Gly Gly Pro Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser 
            180                 185                 190         


Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile 
            260                 265                 270         


Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln 
        275                 280                 285             


Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln 
    290                 295                 300                 


Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro 
                325                 330                 335     


Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser 
            340                 345                 350         


Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe 
                405                 410                 415     


Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440 


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  18

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Glu Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Arg Thr Ser Thr Leu Glu Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Ile Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly 
        115     


<210>  19
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  19

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Ala Phe Ser Asn Asp Tyr 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Cys Ile Phe Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Ala Ile Ser Val Leu Gly Tyr Phe Tyr Ala Ala Tyr Phe 
            100                 105                 110         


Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  20

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Gln Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Asp Ser 
            20                  25                  30          


Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Phe Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Ile Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ile Ser Gly Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly 
        115     


<210>  21
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  21

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Asn Ser Ser Ser 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Phe Thr Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Gln Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Ala Tyr Phe Leu Val Gly Tyr Phe Tyr Ala Thr Tyr Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  22
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  22

Ala Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Glu Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Asp Gly Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Tyr Gly Trp Asp Ala Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Gly 
        115     


<210>  23
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  23

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Phe Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu His Val Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Leu Ser Val Val Gly Tyr Phe Tyr Ala Ala Tyr 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  24

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Gly Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Arg Asn 
            20                  25                  30          


Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Asn Tyr Gly Thr Arg 
                85                  90                  95      


Arg Asn Asn Tyr Val Phe Pro Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Gly 
        


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  25

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Pro Gly Trp Ser Asn Gly Phe Ala Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  26

Ala Asp Ile Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Asn 
            20                  25                  30          


Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Glu Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp 
65                  70                  75                  80  


Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Asp Tyr Ile 
                85                  90                  95      


Ile Ile Glu Asn Ile Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


<210>  27
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  27

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Asn 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Phe Ile Asn Ser Asp Asp Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Phe Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Tyr Asp 
                85                  90                  95      


Trp Asp Tyr Tyr Tyr Ser Arg Leu Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  28

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Phe Ser Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Arg Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Gly Ser 
                85                  90                  95      


Ile Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110 


<210>  29
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  29

Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser Leu 
1               5                   10                  15      


Thr Leu Thr Cys Thr Thr Ser Gly Phe Ser Leu Ser Asp Asn Tyr Leu 
            20                  25                  30          


Cys Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val Ala Cys 
        35                  40                  45              


Ile Gly Ile Val Leu Arg Ser Thr Gly Ala Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Glu Gly Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Thr 
65                  70                  75                  80  


Leu Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Leu Asp Leu Gly Tyr Gly Gly Pro Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  30

Arg Ala Ser Glu Asp Ile Glu Ser Phe Leu Ala 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  31

Gln Ala Ser Glu Ser Ile Asp Ser Asp Leu Ser 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  32

Gln Ala Ser Gln Ser Ile Arg Asn Glu Leu Ser 
1               5                   10      


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  33

Gln Ser Ser Glu Ser Val Tyr Asn Asn Asn Tyr Leu Ser 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  34

Gln Ala Ser Gln Ser Val Tyr Asn Asn Lys Asn Leu Ala 
1               5                   10              


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  35

Arg Thr Ser Thr Leu Glu Ser 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  36

Arg Thr Phe Thr Leu Glu Ser 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  37

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  38

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  39

Phe Ser Ser Thr Leu Ala Ser 
1               5           


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  40

Gln Cys Thr Asp Gly Ser Ser Ser Ser Ser Ser Tyr Gly Trp Asp Ala 
1               5                   10                  15      


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  41

Gln Cys Thr Asp Gly Ser Ser Ile Ser Gly Ser Tyr Gly Trp Asp Ala 
1               5                   10                  15      


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  42

Gln Asn Asn Tyr Gly Thr Arg Arg Asn Asn Tyr Val Phe Pro 
1               5                   10                  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  43

Leu Gly Asp Tyr Ile Ile Ile Glu Asn Ile 
1               5                   10  


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  44

Leu Gly Glu Phe Gly Ser Ile Trp Ala 
1               5                   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  45

Asn Asp Tyr Met Cys 
1               5   


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  46

Ser Ser Ser Tyr Met Cys 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  47

Ser Asn Tyr Tyr Met Cys 
1               5       


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  48

Ser Tyr Ala Met Ile 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  49

Thr Tyr Asn Met Cys 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  50

Asp Asn Tyr Leu Cys 
1               5   


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  51

Cys Ile Phe Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  52

Cys Ile Phe Thr Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Thr Trp Ala 
1               5                   10                  15      


Gln Gly 
        


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  53

Phe Ile Asp Ala Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  54

Phe Ile Asn Ser Asp Asp Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  55

Cys Ile Gly Ile Val Leu Arg Ser Thr Gly Ala Thr Tyr Tyr Ala Ser 
1               5                   10                  15      


Trp Ala Glu Gly 
            20  


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  56

Asp Arg Ala Ile Ser Val Leu Gly Tyr Phe Tyr Ala Ala Tyr Phe Phe 
1               5                   10                  15      


Asp Phe 
        


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  57

Asp Arg Ala Tyr Phe Leu Val Gly Tyr Phe Tyr Ala Thr Tyr Tyr Phe 
1               5                   10                  15      


Asp Leu 
        


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  58

Asp Arg Ala Leu Ser Val Val Gly Tyr Phe Tyr Ala Ala Tyr Tyr Phe 
1               5                   10                  15      


Asp Phe 
        


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  59

Gly Asp Pro Gly Trp Ser Asn Gly Phe Ala Leu 
1               5                   10      


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  60

Tyr Asp Trp Asp Tyr Tyr Tyr Ser Arg Leu Asp Leu 
1               5                   10          


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  61

Asp Leu Gly Tyr Gly Gly Pro Leu 
1               5               


<210>  62
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  62

His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210>  63
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  64
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  65
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  66
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  67
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  68
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  69
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  69

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  70
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  71
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  72
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  72
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cagctgtggg aggcacagtc       60

accatcaatt gccgggccag tgaggacatt gaaagctttt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctcc aggacatcca ctctggaatc tggggtctca      180

tcgcggttca aaggcagtgg atcggggaca gagttcattc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa tgtactgatg gtagtagtag tagtagtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggt                   348


<210>  73
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  73
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cgcaggtggg aggcacagtc       60

accatcaatt gccaggccag tgagagcatt gatagtgact tatcctggta tcaacagaaa      120

ccagggcagc ctcccaagct cctgatctac aggacattca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gactacactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccattta ctactgtcaa tgcactgatg gtagtagtat tagtggtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggt                   348


<210>  74
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  74
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cagctgtggg aggcacagtc       60

accatcaatt gccgggccag tgaggacatt gaaagctttt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatgtcc aggacatcca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccacata ttactgtcaa tgtactgatg gtagtagtag tagtagtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggt                   348


<210>  75
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  75
gctgacattg tgatgaccca gactccagcc tccgtgtctg gagctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt aggaatgaat tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac aaggcatcca ctctggcatc tggggtccca      180

tcgcggttca gtggcagtgg atttgggaca gagttcactc tcaccatcag cggtgtgcag      240

tgtgatgatg ctgccactta ctactgtcaa aacaattatg gtactaggcg taataattat      300

gtttttcctt tcggcggagg gaccgaggtg gtggtcaaag gt                         342


<210>  76
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  76
gctgacatcg tgctgaccca gactccagcc tccgtgtctg cagctgtggg aggcacagtc       60

agcatcagtt gccagtccag tgaaagtgtt tataataaca actacttatc ctggtttcag      120

cagaaaccag ggcagcctcc caagctcctg atctatggtg catccactct ggcatctggg      180

gtcccatcgc ggtttgaagg cagtggatct gggacacagt tcactctcac catcagcgac      240

gtgcagtgtg atgatgctgc cacttactac tgtctaggcg attatattat tattgagaat      300

attttcggcg gagggaccga ggtggtggtc aaaggt                                336


<210>  77
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  77
gcgcaagtgc tgacccagac tccagcctcc gtgtctgcgg ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagtgtttat aacaacaaaa atttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatttttcat ccactctggc atctggggtc      180

ccatcgcggt tcagaggcag tggatctggg acacagttca ctctcaccat cagtggcgtg      240

cagtgtggcg atgctgccac ttactactgt ctaggcgaat ttggtagtat ttgggctttc      300

ggcggaggga ccgaggtggt ggtcaaaggt                                       330


<210>  78
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  78
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatctct gacactcacc       60

tgcaaagcct ctggaatcgc cttcagtaac gactacatgt gctgggtccg ccaggctcca      120

gggaaggggc tggagtggat cgcatgtatt tttactggta gtagtggtag tacttactac      180

gcgagctggg cgaaaggtcg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agatagggct      300

atttctgtac ttggttattt ctatgctgca tacttctttg acttctgggg cccaggcacc      360

ctggtcaccg tctcctca                                                    378


<210>  79
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  79
cagtcgttgg aggagtccgg gggaggcctg gtccagcctg agggatccct gacactcacc       60

tgcacagctt ctggattctc cttcaatagc agctcctaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atttttactg gtagtagtgg taatacctac      180

tacgcgacct gggcgcaagg tcgattcacc atctccaaga cctcgaccac ggtgactctg      240

gaaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agatagggct      300

tattttttgg ttggttattt ctatgctaca tattattttg acttatgggg cccaggcacc      360

ctggtcaccg tctcctca                                                    378


<210>  80
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  80
cagtcgttgg aggagtccgg gggaggcctg gtccagcctg gggcatctct gacactcacc       60

tgtacagcct ctggattctc cttcagtagc aactactaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcatgc atttttactg gtagtagtgg tagcacttac      180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcacgtga ccagtctgac agccgcggac acggccacct atttctgtgc gagagatagg      300

gctttgtctg ttgttggtta tttctatgct gcatactact ttgacttctg gggcccaggc      360

accctggtca ccgtctcctc a                                                381


<210>  81
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  81
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggaatcga cctcagtagc tatgcaatga tctgggtccg ccaggctcca      120

ggagagggac tggaatacat cggattcatt gatgctggtg atggtaacac ttactacgcg      180

agctgggcaa aaggccgatt caccatctcc aaaacctcga ccacggtgga tctgaaaatc      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggaga tcctggttgg      300

agtaatggtt ttgccttgtg gggccaaggc accctggtca ccgtctcctc a               351


<210>  82
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  82
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtacc tacaatatgt gctgggtccg ccaggctcca      120

gggaagggct tggaatgggt cggtttcatt aattctgatg atagcgcgta ctacgcgagc      180

tgggcgaaag gccgcttcac cttctccaag acctcgacca cggtggatct gaaaatcgcc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatatgattg ggattattat      300

tatagtcggt tggatctctg gggcccgggc accctggtca ccgtctcctc a               351


<210>  83
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  83
cagctggagg agtccggggg aggcctggtc cagcctgggg catccctgac actcacctgc       60

acaacttctg gattctctct cagtgataat tatttgtgtt gggtccgcca ggctccaggg      120

cgtgggctgg agtgggtcgc atgcattgga attgttcttc gtagtactgg tgccacttac      180

tacgcgagct gggcggaagg ccgattcacc atctccaaaa cctcgccgac cacggtgact      240

ctggagatga ccagtctgac agccgcggac acggccacct acttctgtgc gctagatctc      300

ggatatggtg gtcctttgtg gggcccgggc accctggtca ccgtctcctc a               351


<210>  84
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  84
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cagctgtggg aggcacagtc       60

accatcaatt gccgggccag tgaggacatt gaaagctttt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctcc aggacatcca ctctggaatc tggggtctca      180

tcgcggttca aaggcagtgg atcggggaca gagttcattc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa tgtactgatg gtagtagtag tagtagtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      360

cctactgtcc tcctcttccc accatctagc gatgaggtgg caactggaac agtcaccatc      420

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      480

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      540

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      600

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcagtaggaa gaactgt         657


<210>  85
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  85
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cgcaggtggg aggcacagtc       60

accatcaatt gccaggccag tgagagcatt gatagtgact tatcctggta tcaacagaaa      120

ccagggcagc ctcccaagct cctgatctac aggacattca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gactacactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccattta ctactgtcaa tgcactgatg gtagtagtat tagtggtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      360

cctactgtcc tcctcttccc accatctagc gatgaggtgg caactggaac agtcaccatc      420

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      480

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      540

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      600

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcagtaggaa gaactgt         657


<210>  86
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  86
gccgatgtcg tgatgaccca gactccatcc cccgtgtctg cagctgtggg aggcacagtc       60

accatcaatt gccgggccag tgaggacatt gaaagctttt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatgtcc aggacatcca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccacata ttactgtcaa tgtactgatg gtagtagtag tagtagtagt      300

tatggttggg atgctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      360

cctactgtcc tcctcttccc accatctagc gatgaggtgg caactggaac agtcaccatc      420

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      480

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      540

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      600

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcagtaggaa gaactgt         657


<210>  87
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  87
gctgacattg tgatgaccca gactccagcc tccgtgtctg gagctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt aggaatgaat tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac aaggcatcca ctctggcatc tggggtccca      180

tcgcggttca gtggcagtgg atttgggaca gagttcactc tcaccatcag cggtgtgcag      240

tgtgatgatg ctgccactta ctactgtcaa aacaattatg gtactaggcg taataattat      300

gtttttcctt tcggcggagg gaccgaggtg gtggtcaaag gtgatccagt tgcacctact      360

gtcctcctct tcccaccatc tagcgatgag gtggcaactg gaacagtcac catcgtgtgt      420

gtggcgaata aatactttcc cgatgtcacc gtcacctggg aggtggatgg caccacccaa      480

acaactggca tcgagaacag taaaacaccg cagaattctg cagattgtac ctacaacctc      540

agcagcactc tgacactgac cagcacacag tacaacagcc acaaagagta cacctgcaag      600

gtgacccagg gcacgacctc agtcgtccag agcttcagta ggaagaactg t               651


<210>  88
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  88
gctgacatcg tgctgaccca gactccagcc tccgtgtctg cagctgtggg aggcacagtc       60

agcatcagtt gccagtccag tgaaagtgtt tataataaca actacttatc ctggtttcag      120

cagaaaccag ggcagcctcc caagctcctg atctatggtg catccactct ggcatctggg      180

gtcccatcgc ggtttgaagg cagtggatct gggacacagt tcactctcac catcagcgac      240

gtgcagtgtg atgatgctgc cacttactac tgtctaggcg attatattat tattgagaat      300

attttcggcg gagggaccga ggtggtggtc aaaggtgatc cagttgcacc tactgtcctc      360

ctcttcccac catctagcga tgaggtggca actggaacag tcaccatcgt gtgtgtggcg      420

aataaatact ttcccgatgt caccgtcacc tgggaggtgg atggcaccac ccaaacaact      480

ggcatcgaga acagtaaaac accgcagaat tctgcagatt gtacctacaa cctcagcagc      540

actctgacac tgaccagcac acagtacaac agccacaaag agtacacctg caaggtgacc      600

cagggcacga cctcagtcgt ccagagcttc agtaggaaga actgt                      645


<210>  89
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  89
gcgcaagtgc tgacccagac tccagcctcc gtgtctgcgg ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagtgtttat aacaacaaaa atttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatttttcat ccactctggc atctggggtc      180

ccatcgcggt tcagaggcag tggatctggg acacagttca ctctcaccat cagtggcgtg      240

cagtgtggcg atgctgccac ttactactgt ctaggcgaat ttggtagtat ttgggctttc      300

ggcggaggga ccgaggtggt ggtcaaaggt gatccagttg cacctactgt cctcctcttc      360

ccaccatcta gcgatgaggt ggcaactgga acagtcacca tcgtgtgtgt ggcgaataaa      420

tactttcccg atgtcaccgt cacctgggag gtggatggca ccacccaaac aactggcatc      480

gagaacagta aaacaccgca gaattctgca gattgtacct acaacctcag cagcactctg      540

acactgacca gcacacagta caacagccac aaagagtaca cctgcaaggt gacccagggc      600

acgacctcag tcgtccagag cttcagtagg aagaactgt                             639


<210>  90
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  90
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatctct gacactcacc       60

tgcaaagcct ctggaatcgc cttcagtaac gactacatgt gctgggtccg ccaggctcca      120

gggaaggggc tggagtggat cgcatgtatt tttactggta gtagtggtag tacttactac      180

gcgagctggg cgaaaggtcg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agatagggct      300

atttctgtac ttggttattt ctatgctgca tacttctttg acttctgggg cccaggcacc      360

ctggtcaccg tctcctcagg gcaacctaag gctccatcag tcttcccact ggccccctgc      420

tgcggggaca cacccagctc cacggtgacc ttgggctgcc tggtcaaagg ctacctcccg      480

gagccagtga ccgtgacctg gaactcgggc accctcacca atggggtacg caccttcccg      540

tccgtccggc agtcctcagg cctctactcg ctgagcagcg tggtgagcgt gacctcaagc      600

agccagcccg tcacctgcaa cgtggcccac ccagccacca acaccaaagt ggacaagacc      660

gttgcgccct cgacatgcag caagcccacg tgcccacccc ctgaactcct ggggggaccg      720

tctgtcttca tcttcccccc aaaacccaag gacaccctca tgatctcacg cacccccgag      780

gtcacatgcg tggtggtgga cgtgagccag gatgaccccg aggtgcagtt cacatggtac      840

ataaacaacg agcaggtgcg caccgcccgg ccgccgctac gggagcagca gttcaacagc      900

acgatccgcg tggtcagcac cctccccatc gcgcaccagg actggctgag gggcaaggag      960

ttcaagtgca aagtccacaa caaggcactc ccggccccca tcgagaaaac catctccaaa     1020

gccagagggc agcccctgga gccgaaggtc tacaccatgg gccctccccg ggaggagctg     1080

agcagcaggt cggtcagcct gacctgcatg atcaacggct tctacccttc cgacatctcg     1140

gtggagtggg agaagaacgg gaaggcagag gacaactaca agaccacgcc ggccgtgctg     1200

gacagcgacg gctcctactt cctctacagc aagctctcag tgcccacgag tgagtggcag     1260

cggggcgacg tcttcacctg ctccgtgatg cacgaggcct tgcacaacca ctacacgcag     1320

aagtccatct cccgctctcc gggtaaa                                         1347


<210>  91
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  91
cagtcgttgg aggagtccgg gggaggcctg gtccagcctg agggatccct gacactcacc       60

tgcacagctt ctggattctc cttcaatagc agctcctaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atttttactg gtagtagtgg taatacctac      180

tacgcgacct gggcgcaagg tcgattcacc atctccaaga cctcgaccac ggtgactctg      240

gaaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agatagggct      300

tattttttgg ttggttattt ctatgctaca tattattttg acttatgggg cccaggcacc      360

ctggtcaccg tctcctcagg gcaacctaag gctccatcag tcttcccact ggccccctgc      420

tgcggggaca caccctctag cacggtgacc ttgggctgcc tggtcaaagg ctacctcccg      480

gagccagtga ccgtgacctg gaactcgggc accctcacca atggggtacg caccttcccg      540

tccgtccggc agtcctcagg cctctactcg ctgagcagcg tggtgagcgt gacctcaagc      600

agccagcccg tcacctgcaa cgtggcccac ccagccacca acaccaaagt ggacaagacc      660

gttgcgccct cgacatgcag caagcccacg tgcccacccc ctgaactcct ggggggaccg      720

tctgtcttca tcttcccccc aaaacccaag gacaccctca tgatctcacg cacccccgag      780

gtcacatgcg tggtggtgga cgtgagccag gatgaccccg aggtgcagtt cacatggtac      840

ataaacaacg agcaggtgcg caccgcccgg ccgccgctac gggagcagca gttcaacagc      900

acgatccgcg tggtcagcac cctccccatc gcgcaccagg actggctgag gggcaaggag      960

ttcaagtgca aagtccacaa caaggcactc ccggccccca tcgagaaaac catctccaaa     1020

gccagagggc agcccctgga gccgaaggtc tacaccatgg gccctccccg ggaggagctg     1080

agcagcaggt cggtcagcct gacctgcatg atcaacggct tctacccttc cgacatctcg     1140

gtggagtggg agaagaacgg gaaggcagag gacaactaca agaccacgcc ggccgtgctg     1200

gacagcgacg gctcctactt cctctacagc aagctctcag tgcccacgag tgagtggcag     1260

cggggcgacg tcttcacctg ctccgtgatg cacgaggcct tgcacaacca ctacacgcag     1320

aagtccatct cccgctctcc gggtaaa                                         1347


<210>  92
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  92
cagtcgttgg aggagtccgg gggaggcctg gtccagcctg gggcatctct gacactcacc       60

tgtacagcct ctggattctc cttcagtagc aactactaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcatgc atttttactg gtagtagtgg tagcacttac      180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcacgtga ccagtctgac agccgcggac acggccacct atttctgtgc gagagatagg      300

gctttgtctg ttgttggtta tttctatgct gcatactact ttgacttctg gggcccaggc      360

accctggtca ccgtctcctc agggcaacct aaggctccat cagtcttccc actggccccc      420

tgctgcgggg acacaccctc tagcacggtg accttgggct gcctggtcaa aggctacctc      480

ccggagccag tgaccgtgac ctggaactcg ggcaccctca ccaatggggt acgcaccttc      540

ccgtccgtcc ggcagtcctc aggcctctac tcgctgagca gcgtggtgag cgtgacctca      600

agcagccagc ccgtcacctg caacgtggcc cacccagcca ccaacaccaa agtggacaag      660

accgttgcgc cctcgacatg cagcaagccc acgtgcccac cccctgaact cctgggggga      720

ccgtctgtct tcatcttccc cccaaaaccc aaggacaccc tcatgatctc acgcaccccc      780

gaggtcacat gcgtggtggt ggacgtgagc caggatgacc ccgaggtgca gttcacatgg      840

tacataaaca acgagcaggt gcgcaccgcc cggccgccgc tacgggagca gcagttcaac      900

agcacgatcc gcgtggtcag caccctcccc atcgcgcacc aggactggct gaggggcaag      960

gagttcaagt gcaaagtcca caacaaggca ctcccggccc ccatcgagaa aaccatctcc     1020

aaagccagag ggcagcccct ggagccgaag gtctacacca tgggccctcc ccgggaggag     1080

ctgagcagca ggtcggtcag cctgacctgc atgatcaacg gcttctaccc ttccgacatc     1140

tcggtggagt gggagaagaa cgggaaggca gaggacaact acaagaccac gccggccgtg     1200

ctggacagcg acggctccta cttcctctac agcaagctct cagtgcccac gagtgagtgg     1260

cagcggggcg acgtcttcac ctgctccgtg atgcacgagg ccttgcacaa ccactacacg     1320

cagaagtcca tctcccgctc tccgggtaaa                                      1350


<210>  93
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  93
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggaatcga cctcagtagc tatgcaatga tctgggtccg ccaggctcca      120

ggagagggac tggaatacat cggattcatt gatgctggtg atggtaacac ttactacgcg      180

agctgggcaa aaggccgatt caccatctcc aaaacctcga ccacggtgga tctgaaaatc      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggaga tcctggttgg      300

agtaatggtt ttgccttgtg gggccaaggc accctggtca ccgtctcctc agggcaacct      360

aaggctccat cagtcttccc actggccccc tgctgcgggg acacaccctc tagcacggtg      420

accttgggct gcctggtcaa aggctacctc ccggagccag tgaccgtgac ctggaactcg      480

ggcaccctca ccaatggggt acgcaccttc ccgtccgtcc ggcagtcctc aggcctctac      540

tcgctgagca gcgtggtgag cgtgacctca agcagccagc ccgtcacctg caacgtggcc      600

cacccagcca ccaacaccaa agtggacaag accgttgcgc cctcgacatg cagcaagccc      660

acgtgcccac cccctgaact cctgggggga ccgtctgtct tcatcttccc cccaaaaccc      720

aaggacaccc tcatgatctc acgcaccccc gaggtcacat gcgtggtggt ggacgtgagc      780

caggatgacc ccgaggtgca gttcacatgg tacataaaca acgagcaggt gcgcaccgcc      840

cggccgccgc tacgggagca gcagttcaac agcacgatcc gcgtggtcag caccctcccc      900

atcgcgcacc aggactggct gaggggcaag gagttcaagt gcaaagtcca caacaaggca      960

ctcccggccc ccatcgagaa aaccatctcc aaagccagag ggcagcccct ggagccgaag     1020

gtctacacca tgggccctcc ccgggaggag ctgagcagca ggtcggtcag cctgacctgc     1080

atgatcaacg gcttctaccc ttccgacatc tcggtggagt gggagaagaa cgggaaggca     1140

gaggacaact acaagaccac gccggccgtg ctggacagcg acggctccta cttcctctac     1200

agcaagctct cagtgcccac gagtgagtgg cagcggggcg acgtcttcac ctgctccgtg     1260

atgcacgagg ccttgcacaa ccactacacg cagaagtcca tctcccgctc tccgggtaaa     1320


<210>  94
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  94
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtacc tacaatatgt gctgggtccg ccaggctcca      120

gggaagggct tggaatgggt cggtttcatt aattctgatg atagcgcgta ctacgcgagc      180

tgggcgaaag gccgcttcac cttctccaag acctcgacca cggtggatct gaaaatcgcc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatatgattg ggattattat      300

tatagtcggt tggatctctg gggcccgggc accctggtca ccgtctcctc agggcaacct      360

aaggctccat cagtcttccc actggccccc tgctgcgggg acacaccctc tagcacggtg      420

accttgggct gcctggtcaa aggctacctc ccggagccag tgaccgtgac ctggaactcg      480

ggcaccctca ccaatggggt acgcaccttc ccgtccgtcc ggcagtcctc aggcctctac      540

tcgctgagca gcgtggtgag cgtgacctca agcagccagc ccgtcacctg caacgtggcc      600

cacccagcca ccaacaccaa agtggacaag accgttgcgc cctcgacatg cagcaagccc      660

acgtgcccac cccctgaact cctgggggga ccgtctgtct tcatcttccc cccaaaaccc      720

aaggacaccc tcatgatctc acgcaccccc gaggtcacat gcgtggtggt ggacgtgagc      780

caggatgacc ccgaggtgca gttcacatgg tacataaaca acgagcaggt gcgcaccgcc      840

cggccgccgc tacgggagca gcagttcaac agcacgatcc gcgtggtcag caccctcccc      900

atcgcgcacc aggactggct gaggggcaag gagttcaagt gcaaagtcca caacaaggca      960

ctcccggccc ccatcgagaa aaccatctcc aaagccagag ggcagcccct ggagccgaag     1020

gtctacacca tgggccctcc ccgggaggag ctgagcagca ggtcggtcag cctgacctgc     1080

atgatcaacg gcttctaccc ttccgacatc tcggtggagt gggagaagaa cgggaaggca     1140

gaggacaact acaagaccac gccggccgtg ctggacagcg acggctccta cttcctctac     1200

agcaagctct cagtgcccac gagtgagtgg cagcggggcg acgtcttcac ctgctccgtg     1260

atgcacgagg ccttgcacaa ccactacacg cagaagtcca tctcccgctc tccgggtaaa     1320


<210>  95
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  95
cagctggagg agtccggggg aggcctggtc cagcctgggg catccctgac actcacctgc       60

acaacttctg gattctctct cagtgataat tatttgtgtt gggtccgcca ggctccaggg      120

cgtgggctgg agtgggtcgc atgcattgga attgttcttc gtagtactgg tgccacttac      180

tacgcgagct gggcggaagg ccgattcacc atctccaaaa cctcgccgac cacggtgact      240

ctggagatga ccagtctgac agccgcggac acggccacct acttctgtgc gctagatctc      300

ggatatggtg gtcctttgtg gggcccgggc accctggtca ccgtctcctc agggcaacct      360

aaggctccat cagtcttccc actggccccc tgctgcgggg acacaccctc tagcacggtg      420

accttgggct gcctggtcaa aggctacctc ccggagccag tgaccgtgac ctggaactcg      480

ggcaccctca ccaatggggt acgcaccttc ccgtccgtcc ggcagtcctc aggcctctac      540

tcgctgagca gcgtggtgag cgtgacctca agcagccagc ccgtcacctg caacgtggcc      600

cacccagcca ccaacaccaa agtggacaag accgttgcgc cctcgacatg cagcaagccc      660

acgtgcccac cccctgaact cctgggggga ccgtctgtct tcatcttccc cccaaaaccc      720

aaggacaccc tcatgatctc acgcaccccc gaggtcacat gcgtggtggt ggacgtgagc      780

caggatgacc ccgaggtgca gttcacatgg tacataaaca acgagcaggt gcgcaccgcc      840

cggccgccgc tacgggagca gcagttcaac agcacgatcc gcgtggtcag caccctcccc      900

atcgcgcacc aggactggct gaggggcaag gagttcaagt gcaaagtcca caacaaggca      960

ctcccggccc ccatcgagaa aaccatctcc aaagccagag ggcagcccct ggagccgaag     1020

gtctacacca tgggccctcc ccgggaggag ctgagcagca ggtcggtcag cctgacctgc     1080

atgatcaacg gcttctaccc ttccgacatc tcggtggagt gggagaagaa cgggaaggca     1140

gaggacaact acaagaccac gccggccgtg ctggacagcg acggctccta cttcctctac     1200

agcaagctct cagtgcccac gagtgagtgg cagcggggcg acgtcttcac ctgctccgtg     1260

atgcacgagg ccttgcacaa ccactacacg cagaagtcca tctcccgctc tccgggtaaa     1320


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  97

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  98
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  98

Met Thr Cys Ser Pro Leu Leu Leu Thr Leu Leu Ile His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  99

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  100
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  100

Met Glu Trp Thr Trp Arg Val Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  101
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  101

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  102

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  103
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  103

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  104
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  104

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  105
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  105

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  106
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  106

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  107
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  107

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe 
            20          


<210>  108
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  108

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  109
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  109

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  110
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  110

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Glu 
            20      


<210>  111
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  111

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  112

Val Leu Gly Lys Arg Tyr Lys Gln 
1               5               


<210>  113
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  113

Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val Lys Lys 
1               5                   10                  15      


Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys Gln Arg Val Lys Asn 
            20                  25                  30          


<210>  114
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  114

Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val Lys Lys 
1               5                   10                  15      


Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys Gln Arg Val 
            20                  25                  30  


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  115

Tyr Lys Gln Arg Val Lys Asn Lys 
1               5               


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  116

Leu Gly Lys Arg Tyr Lys Gln Arg Val Lys Asn Lys 
1               5                   10          


<210>  117
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  117

Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys 
1               5                   10                  15      


Arg Tyr Lys Gln Arg Val Lys Asn Lys 
            20                  25  


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  118

Ser Arg Tyr Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val 
1               5                   10                  15      


Leu 
    


<210>  119
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  119

Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val 
1               5                   10                  15      


Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  


<210>  120
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  120

Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val Lys Lys 
1               5                   10                  15      


Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys Gln Arg Val Lys Asn 
            20                  25                  30          


Lys 
    


<210>  121
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  121

Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val Lys Lys 
1               5                   10                  15      


Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys Gln Arg Val Lys 
            20                  25                  30      


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  122

Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala Val Lys 
1               5                   10                  15  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  123

Ser Tyr Ser Arg Tyr Arg Lys Gln Met Ala 
1               5                   10  


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  124

Gln Met Ala Val Lys Lys Tyr Leu 
1               5               


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  125

Val Lys Lys Tyr Leu Ala Ala 
1               5           


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  126

Arg Val Lys Asn Lys 
1               5   


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  127

Arg Tyr Lys Gln Arg Val Lys Asn 
1               5               


