                         SEQUENCE LISTING

<110>  E. I. du Pont de Nemours and Company
       Bendezu, Felipe  Oseas
       Fan, Xiaochun
       Frisch, Ryan L
       HONG, SEUNG-PYO
 
<120>  METHODS AND COMPOSITIONS FOR POL-II BASED GUIDE RNA EXPRESSION

<130>  CL6563WOPCT

<150>  62/269,122
<151>  2015-12-18

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  1372
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp 
    1370         


<210>  2
<211>  543
<212>  DNA
<213>  Yarrowia lipolytica

<400>  2
tcgacgttta aaccatcatc taagggcctc aaaactacct cggaactgct gcgctgatct       60

ggacaccaca gaggttccga gcactttagg ttgcaccaaa tgtcccacca ggtgcaggca      120

gaaaacgctg gaacagcgtg tacagtttgt cttaacaaaa agtgagggcg ctgaggtcga      180

gcagggtggt gtgacttgtt atagccttta gagctgcgaa agcgcgtatg gatttggctc      240

atcaggccag attgagggtc tgtggacaca tgtcatgtta gtgtacttca atcgccccct      300

ggatatagcc ccgacaatag gccgtggcct catttttttg ccttccgcac atttccattg      360

ctcggtaccc acaccttgct tctcctgcac ttgccaacct taatactggt ttacattgac      420

caacatctta caagcggggg gcttgtctag ggtatatata aacagtggct ctcccaatcg      480

gttgccagtc tcttttttcc tttctttccc cacagattcg aaatctaaac tacacatcac      540

acc                                                                    543


<210>  3
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon optimized P. aeruginosa Csy4

<400>  3
atggaccact acctggatat cagactccga cccgacccag agttccctcc tgcccagctc       60

atgtccgtct tgtttggcaa gctgcaccaa gctctcgtgg cccagggtgg agaccgaatt      120

ggcgtgtcgt tccccgattt ggacgagtcc cgttctcgac ttggagaaag actccgtatt      180

catgcttctg cagacgatct cagagctctg cttgcccgac cctggctgga gggtctccga      240

gatcatctgc agttcggcga gcctgccgtg gttccccatc ctaccccata ccgacaggtg      300

tctcgggttc aggccaaaag caaccccgag cgactcagac ggcgtcttat gcgaagacac      360

gacctgtccg aggaggaagc ccgaaagcgg atccccgaca ccgttgctcg agcgttggac      420

cttcctttcg tcacactgcg atctcaatcg actggtcagc actttcgact gttcatcaga      480

cacggacccc tgcaggtcac cgcagaggaa ggcggtttta cttgctatgg actgtccaag      540

ggtggctttg tcccctggtt ctaa                                             564


<210>  4
<211>  659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TDH1:28bp-gCAN1-28bp

<400>  4
cggcggactg cgtccgaacc agctccagca gcgttttttc cgggccattg agccgactgc       60

gaccccgcca acgtgtcttg gcccacgcac tcatgtcatg ttggtgttgg gaggccactt      120

tttaagtagc acaaggcacc tagctcgcag caaggtgtcc gaaccaaaga agcggctgca      180

gtggtgcaaa cggggcggaa acggcgggaa aaagccacgg gggcacgaat tgaggcacgc      240

cctcgaattt gagacgagtc acggccccat tcgcccgcgc aatggctcgc caacgcccgg      300

tcttttgcac cacatcaggt taccccaagc caaacctttg tgttaaaaag cttaacatat      360

tataccgaac gtaggtttgg gcgggcttgc tccgtctgtc caaggcaaca tttatataag      420

ggtctgcatc gccggctcaa ttgaatcttt tttcttcttc tcttctctat attcattctt      480

gaattaaaca cacatcaaca atggttcact gccgtatagg cagctaagaa atcaaacgat      540

tacccaccct cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      600

cttgaaaaag tggcaccgag tcggtgcttt tgttcactgc cgtataggca gctaagaaa       659


<210>  5
<211>  28
<212>  RNA
<213>  Pseudomonas aeruginosa

<400>  5
guucacugcc guauaggcag cuaagaaa                                          28


<210>  6
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Csy4 recognition sequence flanked sgRNA

<400>  6
guucacugcc guauaggcag cuaagaaauc aaacgauuac ccacccucgu uuuagagcua       60

gaaauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg      120

gugcuuuugu ucacugccgu auaggcagcu aagaaa                                156


<210>  7
<211>  23
<212>  DNA
<213>  Yarrowia lipolytica

<400>  7
tcaaacgatt acccaccctc cgg                                               23


<210>  8
<211>  500
<212>  DNA
<213>  Yarrowia lipolytica

<400>  8
cggcggactg cgtccgaacc agctccagca gcgttttttc cgggccattg agccgactgc       60

gaccccgcca acgtgtcttg gcccacgcac tcatgtcatg ttggtgttgg gaggccactt      120

tttaagtagc acaaggcacc tagctcgcag caaggtgtcc gaaccaaaga agcggctgca      180

gtggtgcaaa cggggcggaa acggcgggaa aaagccacgg gggcacgaat tgaggcacgc      240

cctcgaattt gagacgagtc acggccccat tcgcccgcgc aatggctcgc caacgcccgg      300

tcttttgcac cacatcaggt taccccaagc caaacctttg tgttaaaaag cttaacatat      360

tataccgaac gtaggtttgg gcgggcttgc tccgtctgtc caaggcaaca tttatataag      420

ggtctgcatc gccggctcaa ttgaatcttt tttcttcttc tcttctctat attcattctt      480

gaattaaaca cacatcaaca                                                  500


<210>  9
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLS fused to Yarrowia codon optimized P. aeruginosa Csy4

<400>  9
atgcccaaga agaagcgaaa agtcgaccac tacctggata tcagactccg acccgaccca       60

gagttccctc ctgcccagct catgtccgtc ttgtttggca agctgcacca agctctcgtg      120

gcccagggtg gagaccgaat tggcgtgtcg ttccccgatt tggacgagtc ccgttctcga      180

cttggagaaa gactccgtat tcatgcttct gcagacgatc tcagagctct gcttgcccga      240

ccctggctgg agggtctccg agatcatctg cagttcggcg agcctgccgt ggttccccat      300

cctaccccat accgacaggt gtctcgggtt caggccaaaa gcaaccccga gcgactcaga      360

cggcgtctta tgcgaagaca cgacctgtcc gaggaggaag cccgaaagcg gatccccgac      420

accgttgctc gagcgttgga ccttcctttc gtcacactgc gatctcaatc gactggtcag      480

cactttcgac tgttcatcag acacggaccc ctgcaggtca ccgcagagga aggcggtttt      540

acttgctatg gactgtccaa gggtggcttt gtcccctggt tctaa                      585


<210>  10
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  10

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  11
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARS18 sequence

<400>  11
aattcatgtc acacaaaccg atcttcgcct caaggaaacc taattctaca tccgagagac       60

tgccgagatc cagtctacac tgattaattt tcgggccaat aatttaaaaa aatcgtgtta      120

tataatatta tatgtattat atatatacat catgatgata ctgacagtca tgtcccattg      180

ctaaatagac agactccatc tgccgcctcc aactgatgtt ctcaatattt aaggggtcat      240

ctcgcattgt ttaataataa acagactcca tctaccgcct ccaaatgatg ttctcaaaat      300

atattgtatg aacttatttt tattacttag tattattaga caacttactt gctttatgaa      360

aaacacttcc tatttaggaa acaatttata atggcagttc gttcatttaa caatttatgt      420

agaataaatg ttataaatgc gtatgggaaa tcttaaatat ggatagcata aatgatatct      480

gcattgccta attcgaaatc aacagcaacg aaaaaaatcc cttgtacaac ataaatagtc      540

atcgagaaat atcaactatc aaagaacagc tattcacacg ttactattga gattattatt      600

ggacgagaat cacacactca actgtctttc tctcttctag aaatacaggt acaagtatgt      660

actattctca ttgttcatac ttctagtcat ttcatcccac atattccttg gatttctctc      720

caatgaatga cattctatct tgcaaattca acaattataa taagatatac caaagtagcg      780

gtatagtggc aatcaaaaag cttctctggt gtgcttctcg tatttatttt tattctaatg      840

atccattaaa ggtatatatt tatttcttgt tatataatcc ttttgtttat tacatgggct      900

ggatacataa aggtattttg atttaatttt ttgcttaaat tcaatccccc ctcgttcagt      960

gtcaactgta atggtaggaa attaccatac ttttgaagaa gcaaaaaaaa tgaaagaaaa     1020

aaaaaatcgt atttccaggt tagacgttcc gcagaatcta gaatgcggta tgcggtacat     1080

tgttcttcga acgtaaaagt tgcgctccct gagatattgt acatttttgc ttttacaagt     1140

acaagtacat cgtacaacta tgtactactg ttgatgcatc cacaacagtt tgttttgttt     1200

ttttttgttt tttttttttc taatgattca ttaccgctat gtatacctac ttgtacttgt     1260

agtaagccgg gttattggcg ttcaattaat catagactta tgaatctgca cggtgtgcgc     1320

tgcgagttac ttttagctta tgcatgc                                         1347


<210>  12
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full length ARS18 sequence

<400>  12
aattcatgtc acacaaaccg atcttcgcct caaggaaacc taattctaca tccgagagac       60

tgccgagatc cagtctacac tgattaattt tcgggccaat aatttaaaaa aatcgtgtta      120

tataatatta tatgtattat atatatacat catgatgata ctgacagtca tgtcccattg      180

ctaaatagac agactccatc tgccgcctcc aactgatgtt ctcaatattt aaggggtcat      240

ctcgcattgt ttaataataa acagactcca tctaccgcct ccaaatgatg ttctcaaaat      300

atattgtatg aacttatttt tattacttag tattattaga caacttactt gctttatgaa      360

aaacacttcc tatttaggaa acaatttata atggcagttc gttcatttaa caatttatgt      420

agaataaatg ttataaatgc gtatgggaaa tcttaaatat ggatagcata aatgatatct      480

gcattgccta attcgaaatc aacagcaacg aaaaaaatcc cttgtacaac ataaatagtc      540

atcgagaaat atcaactatc aaagaacagc tattcacacg ttactattga gattattatt      600

ggacgagaat cacacactca actgtctttc tctcttctag aaatacaggt acaagtatgt      660

actattctca ttgttcatac ttctagtcat ttcatcccac atattccttg gatttctctc      720

caatgaatga cattctatct tgcaaattca acaattataa taagatatac caaagtagcg      780

gtatagtggc aatcaaaaag cttctctggt gtgcttctcg tatttatttt tattctaatg      840

atccattaaa ggtatatatt tatttcttgt tatataatcc ttttgtttat tacatgggct      900

ggatacataa aggtattttg atttaatttt ttgcttaaat tcaatccccc ctcgttcagt      960

gtcaactgta atggtaggaa attaccatac ttttgaagaa gcaaaaaaaa tgaaagaaaa     1020

aaaaaatcgt atttccaggt tagacgttcc gcagaatcta gaatgcggta tgcggtacat     1080

tgttcttcga acgtaaaagt tgcgctccct gagatattgt acatttttgc ttttacaagt     1140

acaagtacat cgtacaacta tgtactactg ttgatgcatc cacaacagtt tgttttgttt     1200

ttttttgttt tttttttttc taatgattca ttaccgctat gtatacctac ttgtacttgt     1260

agtaagccgg gttattggcg ttcaattaat catagactta tgaatctgca cggtgtgcgc     1320

tgcgagttac ttttagctta tgcatgctac ttgggtgtaa tattgggatc tgtt           1374


<210>  13
<211>  320
<212>  DNA
<213>  Yarrowia lipolytica

<400>  13
tagctatccg aagatcaaga gcgaagcaag ttgtaagtcc aggacatgtt tcccgcccac       60

gcgagtgatt tataacacct ctcttttttg acacccgctc gccttgaaat tcatgtcaca      120

taaattatag tcaacgacgt ttgaataact tgtcttgtag ttcgatgatg atcatatgat      180

tacattaata gtaattactg tatttgatat atatactaat tacaatagta catattagaa      240

catacaatag ttagtgccgt gaagtggctt aaaataccgc gagtcgatta cgtaatatta      300

tatataatgt caaagtgggg                                                  320


<210>  14
<211>  4140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Yarrowia codon optimized Cas9

<400>  14
atggacaaga aatactccat cggcctggac attggaacca actctgtcgg ctgggctgtc       60

atcaccgacg agtacaaggt gccctccaag aaattcaagg tcctcggaaa caccgatcga      120

cactccatca agaaaaacct cattggtgcc ctgttgttcg attctggcga gactgccgaa      180

gctaccagac tcaagcgaac tgctcggcga cgttacaccc gacggaagaa ccgaatctgc      240

tacctgcagg agatcttttc caacgagatg gccaaggtgg acgattcgtt ctttcatcga      300

ctggaggaat ccttcctcgt cgaggaagac aagaaacacg agcgtcatcc catctttggc      360

aacattgtgg acgaggttgc ttaccacgag aagtatccta ccatctacca tctccgaaag      420

aaactcgtcg attccaccga caaggcggat ctcagactta tctacctcgc tctggcacac      480

atgatcaagt ttcgaggtca tttcctcatc gagggcgatc tcaatcccga caacagcgat      540

gtggacaagc tgttcattca gctcgttcag acctacaacc agctgttcga ggaaaacccc      600

atcaatgcct ccggagtcga tgcaaaggcc atcttgtctg ctcgactctc gaagagcaga      660

cgactggaga acctcattgc ccaacttcct ggcgagaaaa agaacggact gtttggcaac      720

ctcattgccc tttctcttgg tctcacaccc aacttcaagt ccaacttcga tctggcggag      780

gacgccaagc tccagctgtc caaggacacc tacgacgatg acctcgacaa cctgcttgca      840

cagattggcg atcagtacgc cgacctgttt ctcgctgcca agaacctttc ggatgctatt      900

ctcttgtctg acattctgcg agtcaacacc gagatcacaa aggctcccct ttctgcctcc      960

atgatcaagc gatacgacga gcaccatcag gatctcacac tgctcaaggc tcttgtccga     1020

cagcaactgc ccgagaagta caaggagatc tttttcgatc agtcgaagaa cggctacgct     1080

ggatacatcg acggcggagc ctctcaggaa gagttctaca agttcatcaa gccaattctc     1140

gagaagatgg acggaaccga ggaactgctt gtcaagctca atcgagagga tctgcttcgg     1200

aagcaacgaa ccttcgacaa cggcagcatt cctcatcaga tccacctcgg tgagctgcac     1260

gccattcttc gacgtcagga agacttctac ccctttctca aggacaaccg agagaagatc     1320

gagaagattc ttacctttcg aatcccctac tatgttggtc ctcttgccag aggaaactct     1380

cgatttgctt ggatgactcg aaagtccgag gaaaccatca ctccctggaa cttcgaggaa     1440

gtcgtggaca agggtgcctc tgcacagtcc ttcatcgagc gaatgaccaa cttcgacaag     1500

aatctgccca acgagaaggt tcttcccaag cattcgctgc tctacgagta ctttacagtc     1560

tacaacgaac tcaccaaagt caagtacgtt accgagggaa tgcgaaagcc tgccttcttg     1620

tctggcgaac agaagaaagc cattgtcgat ctcctgttca agaccaaccg aaaggtcact     1680

gttaagcagc tcaaggagga ctacttcaag aaaatcgagt gtttcgacag cgtcgagatt     1740

tccggagttg aggaccgatt caacgcctct ttgggcacct atcacgatct gctcaagatt     1800

atcaaggaca aggattttct cgacaacgag gaaaacgagg acattctgga ggacatcgtg     1860

ctcactctta ccctgttcga agatcgggag atgatcgagg aacgactcaa gacatacgct     1920

cacctgttcg acgacaaggt catgaaacaa ctcaagcgac gtagatacac cggctgggga     1980

agactttcgc gaaagctcat caacggcatc agagacaagc agtccggaaa gaccattctg     2040

gactttctca agtccgatgg ctttgccaac cgaaacttca tgcagctcat tcacgacgat     2100

tctcttacct tcaaggagga catccagaag gcacaagtgt ccggtcaggg cgacagcttg     2160

cacgaacata ttgccaacct ggctggttcg ccagccatca agaaaggcat tctccagact     2220

gtcaaggttg tcgacgagct ggtgaaggtc atgggacgtc acaagcccga gaacattgtg     2280

atcgagatgg ccagagagaa ccagacaact caaaagggtc agaaaaactc gcgagagcgg     2340

atgaagcgaa tcgaggaagg catcaaggag ctgggatccc agattctcaa ggagcatccc     2400

gtcgagaaca ctcaactgca gaacgagaag ctgtatctct actatctgca gaatggtcga     2460

gacatgtacg tggatcagga actggacatc aatcgtctca gcgactacga tgtggaccac     2520

attgtccctc aatcctttct caaggacgat tctatcgaca acaaggtcct tacacgatcc     2580

gacaagaaca gaggcaagtc ggacaacgtt cccagcgaag aggtggtcaa aaagatgaag     2640

aactactggc gacagctgct caacgccaag ctcattaccc agcgaaagtt cgacaatctt     2700

accaaggccg agcgaggcgg tctgtccgag ctcgacaagg ctggcttcat caagcgtcaa     2760

ctcgtcgaga ccagacagat cacaaagcac gtcgcacaga ttctcgattc tcggatgaac     2820

accaagtacg acgagaacga caagctcatc cgagaggtca aggtgattac tctcaagtcc     2880

aaactggtct ccgatttccg aaaggacttt cagttctaca aggtgcgaga gatcaacaat     2940

taccaccatg cccacgatgc ttacctcaac gccgtcgttg gcactgcgct catcaagaaa     3000

taccccaagc tcgaaagcga gttcgtttac ggcgattaca aggtctacga cgttcgaaag     3060

atgattgcca agtccgaaca ggagattggc aaggctactg ccaagtactt cttttactcc     3120

aacatcatga actttttcaa gaccgagatc accttggcca acggagagat tcgaaagaga     3180

ccacttatcg agaccaacgg cgaaactgga gagatcgtgt gggacaaggg tcgagacttt     3240

gcaaccgtgc gaaaggttct gtcgatgcct caggtcaaca tcgtcaagaa aaccgaggtt     3300

cagactggcg gattctccaa ggagtcgatt ctgcccaagc gaaactccga caagctcatc     3360

gctcgaaaga aagactggga tcccaagaaa tacggtggct tcgattctcc taccgtcgcc     3420

tattccgtgc ttgtcgttgc gaaggtcgag aagggcaagt ccaaaaagct caagtccgtc     3480

aaggagctgc tcggaattac catcatggag cgatcgagct tcgagaagaa tcccatcgac     3540

ttcttggaag ccaagggtta caaggaggtc aagaaagacc tcattatcaa gctgcccaag     3600

tactctctgt tcgaactgga gaacggtcga aagcgtatgc tcgcctccgc tggcgagctg     3660

cagaagggaa acgagcttgc cttgccttcg aagtacgtca actttctcta tctggcttct     3720

cactacgaga agctcaaggg ttctcccgag gacaacgaac agaagcaact cttcgttgag     3780

cagcacaaac attacctcga cgagattatc gagcagattt ccgagttttc gaagcgagtc     3840

atcctggctg atgccaactt ggacaaggtg ctctctgcct acaacaagca tcgggacaaa     3900

cccattcgag aacaggcgga gaacatcatt cacctgttta ctcttaccaa cctgggtgct     3960

cctgcagctt tcaagtactt cgataccact atcgaccgaa agcggtacac atccaccaag     4020

gaggttctcg atgccaccct gattcaccag tccatcactg gcctgtacga gacccgaatc     4080

gacctgtctc agcttggtgg cgactccaga gccgatccca agaaaaagcg aaaggtctaa     4140


<210>  15
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  15

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  16
<211>  543
<212>  DNA
<213>  Yarrowia lipolytica

<400>  16
tcgacgttta aaccatcatc taagggcctc aaaactacct cggaactgct gcgctgatct       60

ggacaccaca gaggttccga gcactttagg ttgcaccaaa tgtcccacca ggtgcaggca      120

gaaaacgctg gaacagcgtg tacagtttgt cttaacaaaa agtgagggcg ctgaggtcga      180

gcagggtggt gtgacttgtt atagccttta gagctgcgaa agcgcgtatg gatttggctc      240

atcaggccag attgagggtc tgtggacaca tgtcatgtta gtgtacttca atcgccccct      300

ggatatagcc ccgacaatag gccgtggcct catttttttg ccttccgcac atttccattg      360

ctcggtaccc acaccttgct tctcctgcac ttgccaacct taatactggt ttacattgac      420

caacatctta caagcggggg gcttgtctag ggtatatata aacagtggct ctcccaatcg      480

gttgccagtc tcttttttcc tttctttccc cacagattcg aaatctaaac tacacatcac      540

acc                                                                    543


<210>  17
<211>  4683
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Yarrowia optimized expression cassette

<400>  17
tcgacgttta aaccatcatc taagggcctc aaaactacct cggaactgct gcgctgatct       60

ggacaccaca gaggttccga gcactttagg ttgcaccaaa tgtcccacca ggtgcaggca      120

gaaaacgctg gaacagcgtg tacagtttgt cttaacaaaa agtgagggcg ctgaggtcga      180

gcagggtggt gtgacttgtt atagccttta gagctgcgaa agcgcgtatg gatttggctc      240

atcaggccag attgagggtc tgtggacaca tgtcatgtta gtgtacttca atcgccccct      300

ggatatagcc ccgacaatag gccgtggcct catttttttg ccttccgcac atttccattg      360

ctcggtaccc acaccttgct tctcctgcac ttgccaacct taatactggt ttacattgac      420

caacatctta caagcggggg gcttgtctag ggtatatata aacagtggct ctcccaatcg      480

gttgccagtc tcttttttcc tttctttccc cacagattcg aaatctaaac tacacatcac      540

accatggaca agaaatactc catcggcctg gacattggaa ccaactctgt cggctgggct      600

gtcatcaccg acgagtacaa ggtgccctcc aagaaattca aggtcctcgg aaacaccgat      660

cgacactcca tcaagaaaaa cctcattggt gccctgttgt tcgattctgg cgagactgcc      720

gaagctacca gactcaagcg aactgctcgg cgacgttaca cccgacggaa gaaccgaatc      780

tgctacctgc aggagatctt ttccaacgag atggccaagg tggacgattc gttctttcat      840

cgactggagg aatccttcct cgtcgaggaa gacaagaaac acgagcgtca tcccatcttt      900

ggcaacattg tggacgaggt tgcttaccac gagaagtatc ctaccatcta ccacctgcga      960

aagaaactcg tcgattccac cgacaaggcg gatctcagac ttatctacct cgctctggca     1020

cacatgatca agtttcgagg tcatttcctc atcgagggcg atctcaatcc cgacaacagc     1080

gatgtggaca agctgttcat tcagctcgtt cagacctaca accagctgtt cgaggaaaac     1140

cccatcaatg cctccggagt cgatgcaaag gccatcttgt ctgctcgact ctcgaagagc     1200

agacgactgg agaacctcat tgcccaactt cctggcgaga aaaagaacgg actgtttggc     1260

aacctcattg ccctttctct tggtctcaca cccaacttca agtccaactt cgatctggcg     1320

gaggacgcca agctccagct gtccaaggac acctacgacg atgacctcga caacctgctt     1380

gcacagattg gcgatcagta cgccgacctg tttctcgctg ccaagaacct ttcggatgct     1440

attctcttgt ctgacattct gcgagtcaac accgagatca caaaggctcc cctttctgcc     1500

tccatgatca agcgatacga cgagcaccat caggatctca cactgctcaa ggctcttgtc     1560

cgacagcaac tgcccgagaa gtacaaggag atctttttcg atcagtcgaa gaacggctac     1620

gctggataca tcgacggcgg agcctctcag gaagagttct acaagttcat caagccaatt     1680

ctcgagaaga tggacggaac cgaggaactg cttgtcaagc tcaatcgaga ggatctgctt     1740

cggaagcaac gaaccttcga caacggcagc attcctcatc agatccacct cggtgagctg     1800

cacgccattc ttcgacgtca ggaagacttc tacccctttc tcaaggacaa ccgagagaag     1860

atcgagaaga ttcttacctt tcgaatcccc tactatgttg gtcctcttgc cagaggaaac     1920

tctcgatttg cttggatgac tcgaaagtcc gaggaaacca tcactccctg gaacttcgag     1980

gaagtcgtgg acaagggtgc ctctgcacag tccttcatcg agcgaatgac caacttcgac     2040

aagaatctgc ccaacgagaa ggttcttccc aagcattcgc tgctctacga gtactttaca     2100

gtctacaacg aactcaccaa agtcaagtac gttaccgagg gaatgcgaaa gcctgccttc     2160

ttgtctggcg aacagaagaa agccattgtc gatctcctgt tcaagaccaa ccgaaaggtc     2220

actgttaagc agctcaagga ggactacttc aagaaaatcg agtgtttcga cagcgtcgag     2280

atttccggag ttgaggaccg attcaacgcc tctttgggca cctatcacga tctgctcaag     2340

attatcaagg acaaggattt tctcgacaac gaggaaaacg aggacattct ggaggacatc     2400

gtgctcactc ttaccctgtt cgaagatcgg gagatgatcg aggaacgact caagacatac     2460

gctcacctgt tcgacgacaa ggtcatgaaa caactcaagc gacgtagata caccggctgg     2520

ggaagacttt cgcgaaagct catcaacggc atcagagaca agcagtccgg aaagaccatt     2580

ctggactttc tcaagtccga tggctttgcc aaccgaaact tcatgcagct cattcacgac     2640

gattctctta ccttcaagga ggacatccag aaggcacaag tgtccggtca gggcgacagc     2700

ttgcacgaac atattgccaa cctggctggt tcgccagcca tcaagaaagg cattctccag     2760

actgtcaagg ttgtcgacga gctggtgaag gtcatgggac gtcacaagcc cgagaacatt     2820

gtgatcgaga tggccagaga gaaccagaca actcaaaagg gtcagaaaaa ctcgcgagag     2880

cggatgaagc gaatcgagga aggcatcaag gagctgggat cccagattct caaggagcat     2940

cccgtcgaga acactcaact gcagaacgag aagctgtatc tctactatct gcagaatggt     3000

cgagacatgt acgtggatca ggaactggac atcaatcgtc tcagcgacta cgatgtggac     3060

cacattgtcc ctcaatcctt tctcaaggac gattctatcg acaacaaggt ccttacacga     3120

tccgacaaga acagaggcaa gtcggacaac gttcccagcg aagaggtggt caaaaagatg     3180

aagaactact ggcgacagct gctcaacgcc aagctcatta cccagcgaaa gttcgacaat     3240

cttaccaagg ccgagcgagg cggtctgtcc gagctcgaca aggctggctt catcaagcgt     3300

caactcgtcg agaccagaca gatcacaaag cacgtcgcac agattctcga ttctcggatg     3360

aacaccaagt acgacgagaa cgacaagctc atccgagagg tcaaggtgat tactctcaag     3420

tccaaactgg tctccgattt ccgaaaggac tttcagttct acaaggtgcg agagatcaac     3480

aattaccacc atgcccacga tgcttacctc aacgccgtcg ttggcactgc gctcatcaag     3540

aaatacccca agctcgaaag cgagttcgtt tacggcgatt acaaggtcta cgacgttcga     3600

aagatgattg ccaagtccga acaggagatt ggcaaggcta ctgccaagta cttcttttac     3660

tccaacatca tgaacttttt caagaccgag atcaccttgg ccaacggaga gattcgaaag     3720

agaccactta tcgagaccaa cggcgaaact ggagagatcg tgtgggacaa gggtcgagac     3780

tttgcaaccg tgcgaaaggt tctgtcgatg cctcaggtca acatcgtcaa gaaaaccgag     3840

gttcagactg gcggattctc caaggagtcg attctgccca agcgaaactc cgacaagctc     3900

atcgctcgaa agaaagactg ggatcccaag aaatacggtg gcttcgattc tcctaccgtc     3960

gcctattccg tgcttgtcgt tgcgaaggtc gagaagggca agtccaaaaa gctcaagtcc     4020

gtcaaggagc tgctcggaat taccatcatg gagcgatcga gcttcgagaa gaatcccatc     4080

gacttcttgg aagccaaggg ttacaaggag gtcaagaaag acctcattat caagctgccc     4140

aagtactctc tgttcgaact ggagaacggt cgaaagcgta tgctcgcctc cgctggcgag     4200

ctgcagaagg gaaacgagct tgccttgcct tcgaagtacg tcaactttct ctatctggct     4260

tctcactacg agaagctcaa gggttctccc gaggacaacg aacagaagca actcttcgtt     4320

gagcagcaca aacattacct cgacgagatt atcgagcaga tttccgagtt ttcgaagcga     4380

gtcatcctgg ctgatgccaa cttggacaag gtgctctctg cctacaacaa gcatcgggac     4440

aaacccattc gagaacaggc ggagaacatc attcacctgt ttactcttac caacctgggt     4500

gctcctgcag ctttcaagta cttcgatacc actatcgacc gaaagcggta cacatccacc     4560

aaggaggttc tcgatgccac cctgattcac cagtccatca ctggcctgta cgagacccga     4620

atcgacctgt ctcagcttgg tggcgactcc agagccgatc ccaagaaaaa gcgaaaggtc     4680

taa                                                                   4683


<210>  18
<211>  10706
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pZufCas9

<400>  18
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgatttcg acagtaatta attaagtcat acacaagtca gctttcttcg     8700

agcctcatat aagtataagt agttcaacgt attagcactg tacccagcat ctccgtatcg     8760

agaaacacaa caacatgccc cattggacag atcatgcgga tacacaggtt gtgcagtatc     8820

atacatactc gatcagacag gtcgtctgac catcatacaa gctgaacaag cgctccatac     8880

ttgcacgctc tctatataca cagttaaatt acatatccat agtctaacct ctaacagtta     8940

atcttctggt aagcctccca gccagccttc tggtatcgct tggcctcctc aataggatct     9000

cggttctggc cgtacagacc tcggccgaca attatgatat ccgttccggt agacatgaca     9060

tcctcaacag ttcggtactg ctgtccgaga gcgtctccct tgtcgtcaag acccaccccg     9120

ggggtcagaa taagccagtc ctcagagtcg cccttaggtc ggttctgggc aatgaagcca     9180

accacaaact cggggtcgga tcgggcaagc tcaatggtct gcttggagta ctcgccagtg     9240

gccagagagc ccttgcaaga cagctcggcc agcatgagca gacctctggc cagcttctcg     9300

ttgggagagg ggactaggaa ctccttgtac tgggagttct cgtagtcaga gacgtcctcc     9360

ttcttctgtt cagagacagt ttcctcggca ccagctcgca ggccagcaat gattccggtt     9420

ccgggtacac cgtgggcgtt ggtgatatcg gaccactcgg cgattcggtg acaccggtac     9480

tggtgcttga cagtgttgcc aatatctgcg aactttctgt cctcgaacag gaagaaaccg     9540

tgcttaagag caagttcctt gagggggagc acagtgccgg cgtaggtgaa gtcgtcaatg     9600

atgtcgatat gggttttgat catgcacaca taaggtccga ccttatcggc aagctcaatg     9660

agctccttgg tggtggtaac atccagagaa gcacacaggt tggttttctt ggctgccacg     9720

agcttgagca ctcgagcggc aaaggcggac ttgtggacgt tagctcgagc ttcgtaggag     9780

ggcattttgg tggtgaagag gagactgaaa taaatttagt ctgcagaact ttttatcgga     9840

accttatctg gggcagtgaa gtatatgtta tggtaatagt tacgagttag ttgaacttat     9900

agatagactg gactatacgg ctatcggtcc aaattagaaa gaacgtcaat ggctctctgg     9960

gcgtcgcctt tgccgacaaa aatgtgatca tgatgaaagc cagcaatgac gttgcagctg    10020

atattgttgt cggccaaccg cgccgaaaac gcagctgtca gacccacagc ctccaacgaa    10080

gaatgtatcg tcaaagtgat ccaagcacac tcatagttgg agtcgtactc caaaggcggc    10140

aatgacgagt cagacagata ctcgtcgacg tttaaaccat catctaaggg cctcaaaact    10200

acctcggaac tgctgcgctg atctggacac cacagaggtt ccgagcactt taggttgcac    10260

caaatgtccc accaggtgca ggcagaaaac gctggaacag cgtgtacagt ttgtcttaac    10320

aaaaagtgag ggcgctgagg tcgagcaggg tggtgtgact tgttatagcc tttagagctg    10380

cgaaagcgcg tatggatttg gctcatcagg ccagattgag ggtctgtgga cacatgtcat    10440

gttagtgtac ttcaatcgcc ccctggatat agccccgaca ataggccgtg gcctcatttt    10500

tttgccttcc gcacatttcc attgctcggt acccacacct tgcttctcct gcacttgcca    10560

accttaatac tggtttacat tgaccaacat cttacaagcg gggggcttgt ctagggtata    10620

tataaacagt ggctctccca atcggttgcc agtctctttt ttcctttctt tccccacaga    10680

ttcgaaatct aaactacaca tcacac                                         10706


<210>  19
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1tss promoter fragment

<400>  19
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaatcaaa cgattaccca ccctc                                            385


<210>  20
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  tef1 promoter forward

<400>  20
gggttaatta aagagaccgg gttggcggcg c                                      31


<210>  21
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  tef1tss promoter reverse

<400>  21
gagggtgggt aatcgtttga ttgacaagga gagagagaaa                             40


<210>  22
<211>  437
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1UTR promoter fragment

<400>  22
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaactcac acccgaaatc gttaagcatt tccttctgag tataagaatc attcaaatca      420

aacgattacc caccctc                                                     437


<210>  23
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tef1utr promoter reverse

<400>  23
gagggtgggt aatcgtttga tttgaatgat tcttatactc                             40


<210>  24
<211>  513
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1tss promoter fragment

<400>  24
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccatcaaacg attacccacc ctc                                   513


<210>  25
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1 promoter forward

<400>  25
gggttaatta agtttaaacc atcatctaag ggcc                                   34


<210>  26
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1tss reverse

<400>  26
gagggtgggt aatcgtttga tggcaaccga ttgggagagc                             40


<210>  27
<211>  569
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1utr promoter fragment

<400>  27
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccagtctctt ttttcctttc tttccccaca gattcgaaat ctaaactaca      540

catcacacct caaacgatta cccaccctc                                        569


<210>  28
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1utr reverse

<400>  28
gagggtgggt aatcgtttga ggtgtgatgt gtagtttaga                             40


<210>  29
<211>  804
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ACT1 for gRNA

<400>  29
cttcggcatg gcgaatggga ggccgcgtgt ggtgattgct gttgtgcaag cctttgctcg       60

ttttctgctg tatgtaattt aaagaacgat tgtatgaatc gaagtcaagg tgagtgtagt      120

ttgagaagtg taaccccagt gtcatagctg tgtactccat tcattgaagg gtgtagtcgt      180

gttttattgc atgagctcct attactcgta taagtaactg ttttgtaaca cttcatgaac      240

ggagatggta tgaacagaag taataatatc ctggaagtca gctgtgccca gaggtgtgtg      300

tgggtgtggc atactttggg acaacaacac ttgggcagta tgcttagtga ccacgaagag      360

agtgttacct tctgaggtgc gacgtgcagt agttctattg tttttaaatg cgcagtcgtc      420

tttcagaggc tgattcaagc agacgcattc agttgtgttc agttgaggct gatatctcag      480

cacctacagt ttagggaaag cagggttaag atgatgacaa ctctgggtgg taacctggga      540

tatgcggcga tatagcaggt aatgacttaa taactgctca atgatgagta tatacatccc      600

tcctatctat atatccatat ttagtattta catattcatc ttcaccgagc tacaagtaga      660

aggatgtaca tgctgtatct tgcggtgcct gtcgccatgt tttcgacaag ttaagttcgg      720

agtatgcatg caaacaaaaa tacaagtagt caaaatattg gagtatcaaa caacgtgctt      780

cgaaatctct tccaatcgat cccc                                             804


<210>  30
<211>  7973
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pFB23

<400>  30
ggccgcgtgt ggtgattgct gttgtgcaag cctttgctcg ttttctgctg tatgtaattt       60

aaagaacgat tgtatgaatc gaagtcaagg tgagtgtagt ttgagaagtg taaccccagt      120

gtcatagctg tgtactccat tcattgaagg gtgtagtcgt gttttattgc atgagctcct      180

attactcgta taagtaactg ttttgtaaca cttcatgaac ggagatggta tgaacagaag      240

taataatatc ctggaagtca gctgtgccca gaggtgtgtg tgggtgtggc atactttggg      300

acaacaacac ttgggcagta tgcttagtga ccacgaagag agtgttacct tctgaggtgc      360

gacgtgcagt agttctattg tttttaaatg cgcagtcgtc tttcagaggc tgattcaagc      420

agacgcattc agttgtgttc agttgaggct gatatctcag cacctacagt ttagggaaag      480

cagggttaag atgatgacaa ctctgggtgg taacctggga tatgcggcga tatagcaggt      540

aatgacttaa taactgctca atgatgagta tatacatccc tcctatctat atatccatat      600

ttagtattta catattcatc ttcaccgagc tacaagtaga aggatgtaca tgctgtatct      660

tgcggtgcct gtcgccatgt tttcgacaag ttaagttcgg agtatgcatg caaacaaaaa      720

tacaagtagt caaaatattg gagtatcaaa caacgtgctt cgaaatctct tccacaattg      780

gcaatccaag atggatggat tcaacacagg gatatagcga gctacgtggt ggtgcgagga      840

tatagcaacg gatatttatg tttgacactt gagaatgtac gatacaagca ctgtccaagt      900

acaatactaa acatactgta catactcata ctcgtacccg ggcaacggtt tcacttgagt      960

gcagtggcta gtgctcttac tcgtacagtg tgcaatactg cgtatcatag tctttgatgt     1020

atatcgtatt cattcatgtt agttgcgtac gagccggaag cataaagtgt aaagcctggg     1080

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     1140

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     1200

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     1260

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     1320

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     1380

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     1440

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     1500

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     1560

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     1620

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     1680

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     1740

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     1800

tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc     1860

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     1920

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     1980

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     2040

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     2100

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     2160

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     2220

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     2280

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     2340

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     2400

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     2460

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     2520

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     2580

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     2640

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     2700

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     2760

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     2820

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     2880

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     2940

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     3000

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt     3060

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     3120

gcacatttcc ccgaaaagtg ccacctgacg cgccctgtag cggcgcatta agcgcggcgg     3180

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     3240

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     3300

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     3360

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     3420

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     3480

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     3540

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa     3600

tttccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc     3660

gctattacgc cagctggcga aagggggatg tgctgcaagg cgattaagtt gggtaacgcc     3720

agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattgtaat acgactcact     3780

atagggcgaa ttgggtaccg ggccccccct cgaggtcgat ggtgtcgata agcttgatat     3840

cgaattcatg tcacacaaac cgatcttcgc ctcaaggaaa cctaattcta catccgagag     3900

actgccgaga tccagtctac actgattaat tttcgggcca ataatttaaa aaaatcgtgt     3960

tatataatat tatatgtatt atatatatac atcatgatga tactgacagt catgtcccat     4020

tgctaaatag acagactcca tctgccgcct ccaactgatg ttctcaatat ttaaggggtc     4080

atctcgcatt gtttaataat aaacagactc catctaccgc ctccaaatga tgttctcaaa     4140

atatattgta tgaacttatt tttattactt agtattatta gacaacttac ttgctttatg     4200

aaaaacactt cctatttagg aaacaattta taatggcagt tcgttcattt aacaatttat     4260

gtagaataaa tgttataaat gcgtatggga aatcttaaat atggatagca taaatgatat     4320

ctgcattgcc taattcgaaa tcaacagcaa cgaaaaaaat cccttgtaca acataaatag     4380

tcatcgagaa atatcaacta tcaaagaaca gctattcaca cgttactatt gagattatta     4440

ttggacgaga atcacacact caactgtctt tctctcttct agaaatacag gtacaagtat     4500

gtactattct cattgttcat acttctagtc atttcatccc acatattcct tggatttctc     4560

tccaatgaat gacattctat cttgcaaatt caacaattat aataagatat accaaagtag     4620

cggtatagtg gcaatcaaaa agcttctctg gtgtgcttct cgtatttatt tttattctaa     4680

tgatccatta aaggtatata tttatttctt gttatataat ccttttgttt attacatggg     4740

ctggatacat aaaggtattt tgatttaatt ttttgcttaa attcaatccc ccctcgttca     4800

gtgtcaactg taatggtagg aaattaccat acttttgaag aagcaaaaaa aatgaaagaa     4860

aaaaaaaatc gtatttccag gttagacgtt ccgcagaatc tagaatgcgg tatgcggtac     4920

attgttcttc gaacgtaaaa gttgcgctcc ctgagatatt gtacattttt gcttttacaa     4980

gtacaagtac atcgtacaac tatgtactac tgttgatgca tccacaacag tttgttttgt     5040

ttttttttgt tttttttttt tctaatgatt cattaccgct atgtatacct acttgtactt     5100

gtagtaagcc gggttattgg cgttcaatta atcatagact tatgaatctg cacggtgtgc     5160

gctgcgagtt acttttagct tatgcatgct acttgggtgt aatattggga tctgttcgga     5220

aatcaacgga tgctcaatcg atttcgacag taattaatta agtcatacac aagtcagctt     5280

tcttcgagcc tcatataagt ataagtagtt caacgtatta gcactgtacc cagcatctcc     5340

gtatcgagaa acacaacaac atgccccatt ggacagatca tgcggataca caggttgtgc     5400

agtatcatac atactcgatc agacaggtcg tctgaccatc atacaagctg aacaagcgct     5460

ccatacttgc acgctctcta tatacacagt taaattacat atccatagtc taacctctaa     5520

cagttaatct tctggtaagc ctcccagcca gccttctggt atcgcttggc ctcctcaata     5580

ggatctcggt tctggccgta cagacctcgg ccgacaatta tgatatccgt tccggtagac     5640

atgacatcct caacagttcg gtactgctgt ccgagagcgt ctcccttgtc gtcaagaccc     5700

accccggggg tcagaataag ccagtcctca gagtcgccct taggtcggtt ctgggcaatg     5760

aagccaacca caaactcggg gtcggatcgg gcaagctcaa tggtctgctt ggagtactcg     5820

ccagtggcca gagagccctt gcaagacagc tcggccagca tgagcagacc tctggccagc     5880

ttctcgttgg gagaggggac taggaactcc ttgtactggg agttctcgta gtcagagacg     5940

tcctccttct tctgttcaga gacagtttcc tcggcaccag ctcgcaggcc agcaatgatt     6000

ccggttccgg gtacaccgtg ggcgttggtg atatcggacc actcggcgat tcggtgacac     6060

cggtactggt gcttgacagt gttgccaata tctgcgaact ttctgtcctc gaacaggaag     6120

aaaccgtgct taagagcaag ttccttgagg gggagcacag tgccggcgta ggtgaagtcg     6180

tcaatgatgt cgatatgggt tttgatcatg cacacataag gtccgacctt atcggcaagc     6240

tcaatgagct ccttggtggt ggtaacatcc agagaagcac acaggttggt tttcttggct     6300

gccacgagct tgagcactcg agcggcaaag gcggacttgt ggacgttagc tcgagcttcg     6360

taggagggca ttttggtggt gaagaggaga ctgaaataaa tttagtctgc agaacttttt     6420

atcggaacct tatctggggc agtgaagtat atgttatggt aatagttacg agttagttga     6480

acttatagat agactggact atacggctat cggtccaaat tagaaagaac gtcaatggct     6540

ctctgggcgt cgcctttgcc gacaaaaatg tgatcatgat gaaagccagc aatgacgttg     6600

cagctgatat tgttgtcggc caaccgcgcc gaaaacgcag ctgtcagacc cacagcctcc     6660

aacgaagaat gtatcgtcaa agtgatccaa gcacactcat agttggagtc gtactccaaa     6720

ggcggcaatg acgagtcaga cagatactcg tcgacgttta aaccatcatc taagggcctc     6780

aaaactacct cggaactgct gcgctgatct ggacaccaca gaggttccga gcactttagg     6840

ttgcaccaaa tgtcccacca ggtgcaggca gaaaacgctg gaacagcgtg tacagtttgt     6900

cttaacaaaa agtgagggcg ctgaggtcga gcagggtggt gtgacttgtt atagccttta     6960

gagctgcgaa agcgcgtatg gatttggctc atcaggccag attgagggtc tgtggacaca     7020

tgtcatgtta gtgtacttca atcgccccct ggatatagcc ccgacaatag gccgtggcct     7080

catttttttg ccttccgcac atttccattg ctcggtaccc acaccttgct tctcctgcac     7140

ttgccaacct taatactggt ttacattgac caacatctta caagcggggg gcttgtctag     7200

ggtatatata aacagtggct ctcccaatcg gttgccagtc tcttttttcc tttctttccc     7260

cacagattcg aaatctaaac tacacatcac accatggcct cctcggagga cgtcatcaag     7320

gagttcatgc gattcaaggt ccgaatggaa ggctccgtga acggtcacga gtttgagatt     7380

gagggagagg gtgaaggccg accctacgaa ggcacccaga ccgcgaagct gaaggtgacc     7440

aagggtggac ccctgccctt cgcctgggac attctgtctc ctcagtttca gtacggttct     7500

aaggtgtacg tgaagcaccc tgctgacatt cccgactaca agaaactttc ctttcccgag     7560

ggcttcaagt gggagcgagt tatgaacttc gaggatggcg gtgtcgttac cgttactcag     7620

gactcctcgc tccaggacgg ctcgttcatc tacaaggtta agttcatcgg tgtcaacttc     7680

cctagcgatg gacccgtcat gcaaaagaaa actatgggat gggaagcctc tacagagcgg     7740

ctgtaccctc gagacggagt gttgaagggc gagattcaca aggccctgaa gctcaaggac     7800

ggtggacact atctcgttga gtttaagtct atctacatgg caaagaaacc cgtgcagctt     7860

ccaggctact attacgtcga ttccaagctc gatatcacca gccataatga ggactacact     7920

attgtcgaac agtacgagcg tgctgaggga agacaccatc tgtttcttta agc            7973


<210>  31
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Act1 CER forward

<400>  31
accgagtcgg tggtgctttt ggccgcgtgt ggtgattgct                             40


<210>  32
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ACT1 reverse

<400>  32
ggggatcgat tggaagagat ttcgaagcac g                                      31


<210>  33
<211>  804
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ACT1 for HDV gRNA

<400>  33
accgagtcgg tggtgctttt ggccgcgtgt ggtgattgct gttgtgcaag cctttgctcg       60

ttttctgctg tatgtaattt aaagaacgat tgtatgaatc gaagtcaagg tgagtgtagt      120

ttgagaagtg taaccccagt gtcatagctg tgtactccat tcattgaagg gtgtagtcgt      180

gttttattgc atgagctcct attactcgta taagtaactg ttttgtaaca cttcatgaac      240

ggagatggta tgaacagaag taataatatc ctggaagtca gctgtgccca gaggtgtgtg      300

tgggtgtggc atactttggg acaacaacac ttgggcagta tgcttagtga ccacgaagag      360

agtgttacct tctgaggtgc gacgtgcagt agttctattg tttttaaatg cgcagtcgtc      420

tttcagaggc tgattcaagc agacgcattc agttgtgttc agttgaggct gatatctcag      480

cacctacagt ttagggaaag cagggttaag atgatgacaa ctctgggtgg taacctggga      540

tatgcggcga tatagcaggt aatgacttaa taactgctca atgatgagta tatacatccc      600

tcctatctat atatccatat ttagtattta catattcatc ttcaccgagc tacaagtaga      660

aggatgtaca tgctgtatct tgcggtgcct gtcgccatgt tttcgacaag ttaagttcgg      720

agtatgcatg caaacaaaaa tacaagtagt caaaatattg gagtatcaaa caacgtgctt      780

cgaaatctct tccaatcgat cccc                                             804


<210>  34
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ACT1 HDV forward

<400>  34
cttcggcatg gcgaatggga ggccgcgtgt ggtgattgct                             40


<210>  35
<211>  143
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 for FBA1tss

<400>  35
gctctcccaa tcggttgcca tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccgcg tgtggtgatt gct                                              143


<210>  36
<211>  11568
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF84

<400>  36
cgatccctgt gttgaatcca tccatcttgg attgccaatt gtgcacacag aaccgggcac       60

tcacttcccc atccacactt gcggccgccc ccaagcttgt cccattcgcc atgccgaagc      120

atgttgccca gccggcgcca gcgaggaggc tgggaccatg ccggccaaaa gcaccaccga      180

ctcggtgcca ctttttcaag ttgataacgg actagcctta ttttaacttg ctatttctag      240

ctctaaaacg agggtgggta atcgtttgag acgagcttac tcgtttcgtc ctcacggact      300

catcagtcaa accatggtgt gatgtgtagt ttagatttcg aatctgtggg gaaagaaagg      360

aaaaaagaga ctggcaaccg attgggagag ccactgttta tatataccct agacaagccc      420

cccgcttgta agatgttggt caatgtaaac cagtattaag gttggcaagt gcaggagaag      480

caaggtgtgg gtaccgagca atggaaatgt gcggaaggca aaaaaatgag gccacggcct      540

attgtcgggg ctatatccag ggggcgattg aagtacacta acatgacatg tgtccacaga      600

ccctcaatct ggcctgatga gccaaatcca tacgcgcttt cgcagctcta aaggctataa      660

caagtcacac caccctgctc gacctcagcg ccctcacttt ttgttaagac aaactgtaca      720

cgctgttcca gcgttttctg cctgcacctg gtgggacatt tggtgcaacc taaagtgctc      780

ggaacctctg tggtgtccag atcagcgcag cagttccgag gtagttttga ggcccttaga      840

tgatggttta aacgtcgacg agtatctgtc tgactcgtta attaagtcat acacaagtca      900

gctttcttcg agcctcatat aagtataagt agttcaacgt attagcactg tacccagcat      960

ctccgtatcg agaaacacaa caacatgccc cattggacag atcatgcgga tacacaggtt     1020

gtgcagtatc atacatactc gatcagacag gtcgtctgac catcatacaa gctgaacaag     1080

cgctccatac ttgcacgctc tctatataca cagttaaatt acatatccat agtctaacct     1140

ctaacagtta atcttctggt aagcctccca gccagccttc tggtatcgct tggcctcctc     1200

aataggatct cggttctggc cgtacagacc tcggccgaca attatgatat ccgttccggt     1260

agacatgaca tcctcaacag ttcggtactg ctgtccgaga gcgtctccct tgtcgtcaag     1320

acccaccccg ggggtcagaa taagccagtc ctcagagtcg cccttaggtc ggttctgggc     1380

aatgaagcca accacaaact cggggtcgga tcgggcaagc tcaatggtct gcttggagta     1440

ctcgccagtg gccagagagc ccttgcaaga cagctcggcc agcatgagca gacctctggc     1500

cagcttctcg ttgggagagg ggactaggaa ctccttgtac tgggagttct cgtagtcaga     1560

gacgtcctcc ttcttctgtt cagagacagt ttcctcggca ccagctcgca ggccagcaat     1620

gattccggtt ccgggtacac cgtgggcgtt ggtgatatcg gaccactcgg cgattcggtg     1680

acaccggtac tggtgcttga cagtgttgcc aatatctgcg aactttctgt cctcgaacag     1740

gaagaaaccg tgcttaagag caagttcctt gagggggagc acagtgccgg cgtaggtgaa     1800

gtcgtcaatg atgtcgatat gggttttgat catgcacaca taaggtccga ccttatcggc     1860

aagctcaatg agctccttgg tggtggtaac atccagagaa gcacacaggt tggttttctt     1920

ggctgccacg agcttgagca ctcgagcggc aaaggcggac ttgtggacgt tagctcgagc     1980

ttcgtaggag ggcattttgg tggtgaagag gagactgaaa taaatttagt ctgcagaact     2040

ttttatcgga accttatctg gggcagtgaa gtatatgtta tggtaatagt tacgagttag     2100

ttgaacttat agatagactg gactatacgg ctatcggtcc aaattagaaa gaacgtcaat     2160

ggctctctgg gcgtcgcctt tgccgacaaa aatgtgatca tgatgaaagc cagcaatgac     2220

gttgcagctg atattgttgt cggccaaccg cgccgaaaac gcagctgtca gacccacagc     2280

ctccaacgaa gaatgtatcg tcaaagtgat ccaagcacac tcatagttgg agtcgtactc     2340

caaaggcggc aatgacgagt cagacagata ctcgtcgacg tttaaaccat catctaaggg     2400

cctcaaaact acctcggaac tgctgcgctg atctggacac cacagaggtt ccgagcactt     2460

taggttgcac caaatgtccc accaggtgca ggcagaaaac gctggaacag cgtgtacagt     2520

ttgtcttaac aaaaagtgag ggcgctgagg tcgagcaggg tggtgtgact tgttatagcc     2580

tttagagctg cgaaagcgcg tatggatttg gctcatcagg ccagattgag ggtctgtgga     2640

cacatgtcat gttagtgtac ttcaatcgcc ccctggatat agccccgaca ataggccgtg     2700

gcctcatttt tttgccttcc gcacatttcc attgctcggt acccacacct tgcttctcct     2760

gcacttgcca accttaatac tggtttacat tgaccaacat cttacaagcg gggggcttgt     2820

ctagggtata tataaacagt ggctctccca atcggttgcc agtctctttt ttcctttctt     2880

tccccacaga ttcgaaatct aaactacaca tcacaccatg gacaagaaat actccatcgg     2940

cctggacatt ggaaccaact ctgtcggctg ggctgtcatc accgacgagt acaaggtgcc     3000

ctccaagaaa ttcaaggtcc tcggaaacac cgatcgacac tccatcaaga aaaacctcat     3060

tggtgccctg ttgttcgatt ctggcgagac tgccgaagct accagactca agcgaactgc     3120

tcggcgacgt tacacccgac ggaagaaccg aatctgctac ctgcaggaga tcttttccaa     3180

cgagatggcc aaggtggacg attcgttctt tcatcgactg gaggaatcct tcctcgtcga     3240

ggaagacaag aaacacgagc gtcatcccat ctttggcaac attgtggacg aggttgctta     3300

ccacgagaag tatcctacca tctaccacct gcgaaagaaa ctcgtcgatt ccaccgacaa     3360

ggcggatctc agacttatct acctcgctct ggcacacatg atcaagtttc gaggtcattt     3420

cctcatcgag ggcgatctca atcccgacaa cagcgatgtg gacaagctgt tcattcagct     3480

cgttcagacc tacaaccagc tgttcgagga aaaccccatc aatgcctccg gagtcgatgc     3540

aaaggccatc ttgtctgctc gactctcgaa gagcagacga ctggagaacc tcattgccca     3600

acttcctggc gagaaaaaga acggactgtt tggcaacctc attgcccttt ctcttggtct     3660

cacacccaac ttcaagtcca acttcgatct ggcggaggac gccaagctcc agctgtccaa     3720

ggacacctac gacgatgacc tcgacaacct gcttgcacag attggcgatc agtacgccga     3780

cctgtttctc gctgccaaga acctttcgga tgctattctc ttgtctgaca ttctgcgagt     3840

caacaccgag atcacaaagg ctcccctttc tgcctccatg atcaagcgat acgacgagca     3900

ccatcaggat ctcacactgc tcaaggctct tgtccgacag caactgcccg agaagtacaa     3960

ggagatcttt ttcgatcagt cgaagaacgg ctacgctgga tacatcgacg gcggagcctc     4020

tcaggaagag ttctacaagt tcatcaagcc aattctcgag aagatggacg gaaccgagga     4080

actgcttgtc aagctcaatc gagaggatct gcttcggaag caacgaacct tcgacaacgg     4140

cagcattcct catcagatcc acctcggtga gctgcacgcc attcttcgac gtcaggaaga     4200

cttctacccc tttctcaagg acaaccgaga gaagatcgag aagattctta cctttcgaat     4260

cccctactat gttggtcctc ttgccagagg aaactctcga tttgcttgga tgactcgaaa     4320

gtccgaggaa accatcactc cctggaactt cgaggaagtc gtggacaagg gtgcctctgc     4380

acagtccttc atcgagcgaa tgaccaactt cgacaagaat ctgcccaacg agaaggttct     4440

tcccaagcat tcgctgctct acgagtactt tacagtctac aacgaactca ccaaagtcaa     4500

gtacgttacc gagggaatgc gaaagcctgc cttcttgtct ggcgaacaga agaaagccat     4560

tgtcgatctc ctgttcaaga ccaaccgaaa ggtcactgtt aagcagctca aggaggacta     4620

cttcaagaaa atcgagtgtt tcgacagcgt cgagatttcc ggagttgagg accgattcaa     4680

cgcctctttg ggcacctatc acgatctgct caagattatc aaggacaagg attttctcga     4740

caacgaggaa aacgaggaca ttctggagga catcgtgctc actcttaccc tgttcgaaga     4800

tcgggagatg atcgaggaac gactcaagac atacgctcac ctgttcgacg acaaggtcat     4860

gaaacaactc aagcgacgta gatacaccgg ctggggaaga ctttcgcgaa agctcatcaa     4920

cggcatcaga gacaagcagt ccggaaagac cattctggac tttctcaagt ccgatggctt     4980

tgccaaccga aacttcatgc agctcattca cgacgattct cttaccttca aggaggacat     5040

ccagaaggca caagtgtccg gtcagggcga cagcttgcac gaacatattg ccaacctggc     5100

tggttcgcca gccatcaaga aaggcattct ccagactgtc aaggttgtcg acgagctggt     5160

gaaggtcatg ggacgtcaca agcccgagaa cattgtgatc gagatggcca gagagaacca     5220

gacaactcaa aagggtcaga aaaactcgcg agagcggatg aagcgaatcg aggaaggcat     5280

caaggagctg ggatcccaga ttctcaagga gcatcccgtc gagaacactc aactgcagaa     5340

cgagaagctg tatctctact atctgcagaa tggtcgagac atgtacgtgg atcaggaact     5400

ggacatcaat cgtctcagcg actacgatgt ggaccacatt gtccctcaat cctttctcaa     5460

ggacgattct atcgacaaca aggtccttac acgatccgac aagaacagag gcaagtcgga     5520

caacgttccc agcgaagagg tggtcaaaaa gatgaagaac tactggcgac agctgctcaa     5580

cgccaagctc attacccagc gaaagttcga caatcttacc aaggccgagc gaggcggtct     5640

gtccgagctc gacaaggctg gcttcatcaa gcgtcaactc gtcgagacca gacagatcac     5700

aaagcacgtc gcacagattc tcgattctcg gatgaacacc aagtacgacg agaacgacaa     5760

gctcatccga gaggtcaagg tgattactct caagtccaaa ctggtctccg atttccgaaa     5820

ggactttcag ttctacaagg tgcgagagat caacaattac caccatgccc acgatgctta     5880

cctcaacgcc gtcgttggca ctgcgctcat caagaaatac cccaagctcg aaagcgagtt     5940

cgtttacggc gattacaagg tctacgacgt tcgaaagatg attgccaagt ccgaacagga     6000

gattggcaag gctactgcca agtacttctt ttactccaac atcatgaact ttttcaagac     6060

cgagatcacc ttggccaacg gagagattcg aaagagacca cttatcgaga ccaacggcga     6120

aactggagag atcgtgtggg acaagggtcg agactttgca accgtgcgaa aggttctgtc     6180

gatgcctcag gtcaacatcg tcaagaaaac cgaggttcag actggcggat tctccaagga     6240

gtcgattctg cccaagcgaa actccgacaa gctcatcgct cgaaagaaag actgggatcc     6300

caagaaatac ggtggcttcg attctcctac cgtcgcctat tccgtgcttg tcgttgcgaa     6360

ggtcgagaag ggcaagtcca aaaagctcaa gtccgtcaag gagctgctcg gaattaccat     6420

catggagcga tcgagcttcg agaagaatcc catcgacttc ttggaagcca agggttacaa     6480

ggaggtcaag aaagacctca ttatcaagct gcccaagtac tctctgttcg aactggagaa     6540

cggtcgaaag cgtatgctcg cctccgctgg cgagctgcag aagggaaacg agcttgcctt     6600

gccttcgaag tacgtcaact ttctctatct ggcttctcac tacgagaagc tcaagggttc     6660

tcccgaggac aacgaacaga agcaactctt cgttgagcag cacaaacatt acctcgacga     6720

gattatcgag cagatttccg agttttcgaa gcgagtcatc ctggctgatg ccaacttgga     6780

caaggtgctc tctgcctaca acaagcatcg ggacaaaccc attcgagaac aggcggagaa     6840

catcattcac ctgtttactc ttaccaacct gggtgctcct gcagctttca agtacttcga     6900

taccactatc gaccgaaagc ggtacacatc caccaaggag gttctcgatg ccaccctgat     6960

tcaccagtcc atcactggcc tgtacgagac ccgaatcgac ctgtctcagc ttggtggcga     7020

ctccagagcc gatcccaaga aaaagcgaaa ggtctaagcg gccgcaagtg tggatgggga     7080

agtgagtgcc cggttctgtg tgcacaattg gcaatccaag atggatggat tcaacacagg     7140

gatatagcga gctacgtggt ggtgcgagga tatagcaacg gatatttatg tttgacactt     7200

gagaatgtac gatacaagca ctgtccaagt acaatactaa acatactgta catactcata     7260

ctcgtacccg ggcaacggtt tcacttgagt gcagtggcta gtgctcttac tcgtacagtg     7320

tgcaatactg cgtatcatag tctttgatgt atatcgtatt cattcatgtt agttgcgtac     7380

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     7440

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     7500

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc     7560

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg     7620

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag     7680

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     7740

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     7800

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     7860

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     7920

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     7980

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     8040

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     8100

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     8160

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     8220

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     8280

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     8340

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     8400

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     8460

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     8520

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     8580

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     8640

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     8700

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     8760

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     8820

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     8880

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     8940

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     9000

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     9060

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     9120

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     9180

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     9240

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     9300

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     9360

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     9420

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg     9480

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     9540

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     9600

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     9660

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     9720

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     9780

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     9840

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     9900

cgaattttaa caaaatatta acgcttacaa tttccattcg ccattcaggc tgcgcaactg     9960

ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg    10020

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac    10080

gacggccagt gaattgtaat acgactcact atagggcgaa ttgggtaccg ggccccccct    10140

cgaggtcgat ggtgtcgata agcttgatat cgaattcatg tcacacaaac cgatcttcgc    10200

ctcaaggaaa cctaattcta catccgagag actgccgaga tccagtctac actgattaat    10260

tttcgggcca ataatttaaa aaaatcgtgt tatataatat tatatgtatt atatatatac    10320

atcatgatga tactgacagt catgtcccat tgctaaatag acagactcca tctgccgcct    10380

ccaactgatg ttctcaatat ttaaggggtc atctcgcatt gtttaataat aaacagactc    10440

catctaccgc ctccaaatga tgttctcaaa atatattgta tgaacttatt tttattactt    10500

agtattatta gacaacttac ttgctttatg aaaaacactt cctatttagg aaacaattta    10560

taatggcagt tcgttcattt aacaatttat gtagaataaa tgttataaat gcgtatggga    10620

aatcttaaat atggatagca taaatgatat ctgcattgcc taattcgaaa tcaacagcaa    10680

cgaaaaaaat cccttgtaca acataaatag tcatcgagaa atatcaacta tcaaagaaca    10740

gctattcaca cgttactatt gagattatta ttggacgaga atcacacact caactgtctt    10800

tctctcttct agaaatacag gtacaagtat gtactattct cattgttcat acttctagtc    10860

atttcatccc acatattcct tggatttctc tccaatgaat gacattctat cttgcaaatt    10920

caacaattat aataagatat accaaagtag cggtatagtg gcaatcaaaa agcttctctg    10980

gtgtgcttct cgtatttatt tttattctaa tgatccatta aaggtatata tttatttctt    11040

gttatataat ccttttgttt attacatggg ctggatacat aaaggtattt tgatttaatt    11100

ttttgcttaa attcaatccc ccctcgttca gtgtcaactg taatggtagg aaattaccat    11160

acttttgaag aagcaaaaaa aatgaaagaa aaaaaaaatc gtatttccag gttagacgtt    11220

ccgcagaatc tagaatgcgg tatgcggtac attgttcttc gaacgtaaaa gttgcgctcc    11280

ctgagatatt gtacattttt gcttttacaa gtacaagtac atcgtacaac tatgtactac    11340

tgttgatgca tccacaacag tttgttttgt ttttttttgt tttttttttt tctaatgatt    11400

cattaccgct atgtatacct acttgtactt gtagtaagcc gggttattgg cgttcaatta    11460

atcatagact tatgaatctg cacggtgtgc gctgcgagtt acttttagct tatgcatgct    11520

acttgggtgt aatattggga tctgttcgga aatcaacgga tgctcaat                 11568


<210>  37
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 FBA1tss forward

<400>  37
gctctcccaa tcggttgcca tcaaacgatt acccaccctc                             40


<210>  38
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 FBA1tss forward

<400>  38
agcaatcacc acacgcggcc aaaagcacca ccgactcggt                             40


<210>  39
<211>  210
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1-HDV for FBA1tss

<400>  39
gctctcccaa tcggttgcca tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccggc atggtcccag cctcctcgct ggcgccggct gggcaacatg cttcggcatg      180

gcgaatggga ggccgcgtgt ggtgattgct                                       210


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can1-1-HDV Act 1 reverse

<400>  40
agcaatcacc acacgcggcc tcccattcgc catgccgaag                             40


<210>  41
<211>  143
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 for FBA1utr

<400>  41
tctaaactac acatcacacc tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccgcg tgtggtgatt gct                                              143


<210>  42
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 FBA1utr forward

<400>  42
tctaaactac acatcacacc tcaaacgatt acccaccctc                             40


<210>  43
<211>  210
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1-HDV for FBA1utr

<400>  43
tctaaactac acatcacacc tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccggc atggtcccag cctcctcgct ggcgccggct gggcaacatg cttcggcatg      180

gcgaatggga ggccgcgtgt ggtgattgct                                       210


<210>  44
<211>  143
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 for TEF1tss;

<400>  44
tttctctctc tccttgtcaa tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccgcg tgtggtgatt gct                                              143


<210>  45
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 for TEF1tss forward

<400>  45
tttctctctc tccttgtcaa tcaaacgatt acccaccctc                             40


<210>  46
<211>  210
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1-HDV for TEF1tss

<400>  46
tttctctctc tccttgtcaa tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccggc atggtcccag cctcctcgct ggcgccggct gggcaacatg cttcggcatg      180

gcgaatggga ggccgcgtgt ggtgattgct                                       210


<210>  47
<211>  143
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 for TEF1utr

<400>  47
gagtataaga atcattcaaa tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccgcg tgtggtgatt gct                                              143


<210>  48
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1 TEF1utr forward

<400>  48
gagggtgggt aatcgtttga tttgaatgat tcttatactc                             40


<210>  49
<211>  210
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Can1-1-HDV for Tef1utr

<400>  49
gagtataaga atcattcaaa tcaaacgatt acccaccctc gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtggtgct      120

tttggccggc atggtcccag cctcctcgct ggcgccggct gggcaacatg cttcggcatg      180

gcgaatggga ggccgcgtgt ggtgattgct                                       210


<210>  50
<211>  1380
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1TSS-Can1-1-ACT1 cassette

<400>  50
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccatcaaacg attacccacc ctcgttttag agctagaaat agcaagttaa      540

aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtggt gcttttggcc      600

gcgtgtggtg attgctgttg tgcaagcctt tgctcgtttt ctgctgtatg taatttaaag      660

aacgattgta tgaatcgaag tcaaggtgag tgtagtttga gaagtgtaac cccagtgtca      720

tagctgtgta ctccattcat tgaagggtgt agtcgtgttt tattgcatga gctcctatta      780

ctcgtataag taactgtttt gtaacacttc atgaacggag atggtatgaa cagaagtaat      840

aatatcctgg aagtcagctg tgcccagagg tgtgtgtggg tgtggcatac tttgggacaa      900

caacacttgg gcagtatgct tagtgaccac gaagagagtg ttaccttctg aggtgcgacg      960

tgcagtagtt ctattgtttt taaatgcgca gtcgtctttc agaggctgat tcaagcagac     1020

gcattcagtt gtgttcagtt gaggctgata tctcagcacc tacagtttag ggaaagcagg     1080

gttaagatga tgacaactct gggtggtaac ctgggatatg cggcgatata gcaggtaatg     1140

acttaataac tgctcaatga tgagtatata catccctcct atctatatat ccatatttag     1200

tatttacata ttcatcttca ccgagctaca agtagaagga tgtacatgct gtatcttgcg     1260

gtgcctgtcg ccatgttttc gacaagttaa gttcggagta tgcatgcaaa caaaaataca     1320

agtagtcaaa atattggagt atcaaacaac gtgcttcgaa atctcttcca atcgatcccc     1380


<210>  51
<211>  1447
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1TSS-Can1-1HDV-ACT1 cassette

<400>  51
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccatcaaacg attacccacc ctcgttttag agctagaaat agcaagttaa      540

aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtggt gcttttggcc      600

ggcatggtcc cagcctcctc gctggcgccg gctgggcaac atgcttcggc atggcgaatg      660

ggaggccgcg tgtggtgatt gctgttgtgc aagcctttgc tcgttttctg ctgtatgtaa      720

tttaaagaac gattgtatga atcgaagtca aggtgagtgt agtttgagaa gtgtaacccc      780

agtgtcatag ctgtgtactc cattcattga agggtgtagt cgtgttttat tgcatgagct      840

cctattactc gtataagtaa ctgttttgta acacttcatg aacggagatg gtatgaacag      900

aagtaataat atcctggaag tcagctgtgc ccagaggtgt gtgtgggtgt ggcatacttt      960

gggacaacaa cacttgggca gtatgcttag tgaccacgaa gagagtgtta ccttctgagg     1020

tgcgacgtgc agtagttcta ttgtttttaa atgcgcagtc gtctttcaga ggctgattca     1080

agcagacgca ttcagttgtg ttcagttgag gctgatatct cagcacctac agtttaggga     1140

aagcagggtt aagatgatga caactctggg tggtaacctg ggatatgcgg cgatatagca     1200

ggtaatgact taataactgc tcaatgatga gtatatacat ccctcctatc tatatatcca     1260

tatttagtat ttacatattc atcttcaccg agctacaagt agaaggatgt acatgctgta     1320

tcttgcggtg cctgtcgcca tgttttcgac aagttaagtt cggagtatgc atgcaaacaa     1380

aaatacaagt agtcaaaata ttggagtatc aaacaacgtg cttcgaaatc tcttccaatc     1440

gatcccc                                                               1447


<210>  52
<211>  1436
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1UTR-Can1-1-ACT1 cassette

<400>  52
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccagtctctt ttttcctttc tttccccaca gattcgaaat ctaaactaca      540

catcacacct caaacgatta cccaccctcg ttttagagct agaaatagca agttaaaata      600

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtggtgctt ttggccgcgt      660

gtggtgattg ctgttgtgca agcctttgct cgttttctgc tgtatgtaat ttaaagaacg      720

attgtatgaa tcgaagtcaa ggtgagtgta gtttgagaag tgtaacccca gtgtcatagc      780

tgtgtactcc attcattgaa gggtgtagtc gtgttttatt gcatgagctc ctattactcg      840

tataagtaac tgttttgtaa cacttcatga acggagatgg tatgaacaga agtaataata      900

tcctggaagt cagctgtgcc cagaggtgtg tgtgggtgtg gcatactttg ggacaacaac      960

acttgggcag tatgcttagt gaccacgaag agagtgttac cttctgaggt gcgacgtgca     1020

gtagttctat tgtttttaaa tgcgcagtcg tctttcagag gctgattcaa gcagacgcat     1080

tcagttgtgt tcagttgagg ctgatatctc agcacctaca gtttagggaa agcagggtta     1140

agatgatgac aactctgggt ggtaacctgg gatatgcggc gatatagcag gtaatgactt     1200

aataactgct caatgatgag tatatacatc cctcctatct atatatccat atttagtatt     1260

tacatattca tcttcaccga gctacaagta gaaggatgta catgctgtat cttgcggtgc     1320

ctgtcgccat gttttcgaca agttaagttc ggagtatgca tgcaaacaaa aatacaagta     1380

gtcaaaatat tggagtatca aacaacgtgc ttcgaaatct cttccaatcg atcccc         1436


<210>  53
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FBA1UTR-Can1-1HDV-ACT1 cassette

<400>  53
gggttaatta agtttaaacc atcatctaag ggcctcaaaa ctacctcgga actgctgcgc       60

tgatctggac accacagagg ttccgagcac tttaggttgc accaaatgtc ccaccaggtg      120

caggcagaaa acgctggaac agcgtgtaca gtttgtctta acaaaaagtg agggcgctga      180

ggtcgagcag ggtggtgtga cttgttatag cctttagagc tgcgaaagcg cgtatggatt      240

tggctcatca ggccagattg agggtctgtg gacacatgtc atgttagtgt acttcaatcg      300

ccccctggat atagccccga caataggccg tggcctcatt tttttgcctt ccgcacattt      360

ccattgctcg gtacccacac cttgcttctc ctgcacttgc caaccttaat actggtttac      420

attgaccaac atcttacaag cggggggctt gtctagggta tatataaaca gtggctctcc      480

caatcggttg ccagtctctt ttttcctttc tttccccaca gattcgaaat ctaaactaca      540

catcacacct caaacgatta cccaccctcg ttttagagct agaaatagca agttaaaata      600

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtggtgctt ttggccggca      660

tggtcccagc ctcctcgctg gcgccggctg ggcaacatgc ttcggcatgg cgaatgggag      720

gccgcgtgtg gtgattgctg ttgtgcaagc ctttgctcgt tttctgctgt atgtaattta      780

aagaacgatt gtatgaatcg aagtcaaggt gagtgtagtt tgagaagtgt aaccccagtg      840

tcatagctgt gtactccatt cattgaaggg tgtagtcgtg ttttattgca tgagctccta      900

ttactcgtat aagtaactgt tttgtaacac ttcatgaacg gagatggtat gaacagaagt      960

aataatatcc tggaagtcag ctgtgcccag aggtgtgtgt gggtgtggca tactttggga     1020

caacaacact tgggcagtat gcttagtgac cacgaagaga gtgttacctt ctgaggtgcg     1080

acgtgcagta gttctattgt ttttaaatgc gcagtcgtct ttcagaggct gattcaagca     1140

gacgcattca gttgtgttca gttgaggctg atatctcagc acctacagtt tagggaaagc     1200

agggttaaga tgatgacaac tctgggtggt aacctgggat atgcggcgat atagcaggta     1260

atgacttaat aactgctcaa tgatgagtat atacatccct cctatctata tatccatatt     1320

tagtatttac atattcatct tcaccgagct acaagtagaa ggatgtacat gctgtatctt     1380

gcggtgcctg tcgccatgtt ttcgacaagt taagttcgga gtatgcatgc aaacaaaaat     1440

acaagtagtc aaaatattgg agtatcaaac aacgtgcttc gaaatctctt ccaatcgatc     1500

ccc                                                                   1503


<210>  54
<211>  1252
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1TSS-Can1-1-ACT1 cassette

<400>  54
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaatcaaa cgattaccca ccctcgtttt agagctagaa atagcaagtt aaaataaggc      420

tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg gtgcttttgg ccgcgtgtgg      480

tgattgctgt tgtgcaagcc tttgctcgtt ttctgctgta tgtaatttaa agaacgattg      540

tatgaatcga agtcaaggtg agtgtagttt gagaagtgta accccagtgt catagctgtg      600

tactccattc attgaagggt gtagtcgtgt tttattgcat gagctcctat tactcgtata      660

agtaactgtt ttgtaacact tcatgaacgg agatggtatg aacagaagta ataatatcct      720

ggaagtcagc tgtgcccaga ggtgtgtgtg ggtgtggcat actttgggac aacaacactt      780

gggcagtatg cttagtgacc acgaagagag tgttaccttc tgaggtgcga cgtgcagtag      840

ttctattgtt tttaaatgcg cagtcgtctt tcagaggctg attcaagcag acgcattcag      900

ttgtgttcag ttgaggctga tatctcagca cctacagttt agggaaagca gggttaagat      960

gatgacaact ctgggtggta acctgggata tgcggcgata tagcaggtaa tgacttaata     1020

actgctcaat gatgagtata tacatccctc ctatctatat atccatattt agtatttaca     1080

tattcatctt caccgagcta caagtagaag gatgtacatg ctgtatcttg cggtgcctgt     1140

cgccatgttt tcgacaagtt aagttcggag tatgcatgca aacaaaaata caagtagtca     1200

aaatattgga gtatcaaaca acgtgcttcg aaatctcttc caatcgatcc cc             1252


<210>  55
<211>  1319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1TSS-Can1-1-ACT1 cassette

<400>  55
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaatcaaa cgattaccca ccctcgtttt agagctagaa atagcaagtt aaaataaggc      420

tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg gtgcttttgg ccggcatggt      480

cccagcctcc tcgctggcgc cggctgggca acatgcttcg gcatggcgaa tgggaggccg      540

cgtgtggtga ttgctgttgt gcaagccttt gctcgttttc tgctgtatgt aatttaaaga      600

acgattgtat gaatcgaagt caaggtgagt gtagtttgag aagtgtaacc ccagtgtcat      660

agctgtgtac tccattcatt gaagggtgta gtcgtgtttt attgcatgag ctcctattac      720

tcgtataagt aactgttttg taacacttca tgaacggaga tggtatgaac agaagtaata      780

atatcctgga agtcagctgt gcccagaggt gtgtgtgggt gtggcatact ttgggacaac      840

aacacttggg cagtatgctt agtgaccacg aagagagtgt taccttctga ggtgcgacgt      900

gcagtagttc tattgttttt aaatgcgcag tcgtctttca gaggctgatt caagcagacg      960

cattcagttg tgttcagttg aggctgatat ctcagcacct acagtttagg gaaagcaggg     1020

ttaagatgat gacaactctg ggtggtaacc tgggatatgc ggcgatatag caggtaatga     1080

cttaataact gctcaatgat gagtatatac atccctccta tctatatatc catatttagt     1140

atttacatat tcatcttcac cgagctacaa gtagaaggat gtacatgctg tatcttgcgg     1200

tgcctgtcgc catgttttcg acaagttaag ttcggagtat gcatgcaaac aaaaatacaa     1260

gtagtcaaaa tattggagta tcaaacaacg tgcttcgaaa tctcttccaa tcgatcccc      1319


<210>  56
<211>  1304
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1UTR-Can1-1-ACT1 Cassette

<400>  56
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaactcac acccgaaatc gttaagcatt tccttctgag tataagaatc attcaaatca      420

aacgattacc caccctcgtt ttagagctag aaatagcaag ttaaaataag gctagtccgt      480

tatcaacttg aaaaagtggc accgagtcgg tggtgctttt ggccgcgtgt ggtgattgct      540

gttgtgcaag cctttgctcg ttttctgctg tatgtaattt aaagaacgat tgtatgaatc      600

gaagtcaagg tgagtgtagt ttgagaagtg taaccccagt gtcatagctg tgtactccat      660

tcattgaagg gtgtagtcgt gttttattgc atgagctcct attactcgta taagtaactg      720

ttttgtaaca cttcatgaac ggagatggta tgaacagaag taataatatc ctggaagtca      780

gctgtgccca gaggtgtgtg tgggtgtggc atactttggg acaacaacac ttgggcagta      840

tgcttagtga ccacgaagag agtgttacct tctgaggtgc gacgtgcagt agttctattg      900

tttttaaatg cgcagtcgtc tttcagaggc tgattcaagc agacgcattc agttgtgttc      960

agttgaggct gatatctcag cacctacagt ttagggaaag cagggttaag atgatgacaa     1020

ctctgggtgg taacctggga tatgcggcga tatagcaggt aatgacttaa taactgctca     1080

atgatgagta tatacatccc tcctatctat atatccatat ttagtattta catattcatc     1140

ttcaccgagc tacaagtaga aggatgtaca tgctgtatct tgcggtgcct gtcgccatgt     1200

tttcgacaag ttaagttcgg agtatgcatg caaacaaaaa tacaagtagt caaaatattg     1260

gagtatcaaa caacgtgctt cgaaatctct tccaatcgat cccc                      1304


<210>  57
<211>  1304
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TEF1UTR-Can1-1HDV-ACT1 cassette

<400>  57
gggttaatta aagagaccgg gttggcggcg catttgtgtc ccaaaaaaca gccccaattg       60

ccccaattga ccccaaattg acccagtagc gggcccaacc ccggcgagag cccccttctc      120

cccacatatc aaacctcccc cggttcccac acttgccgtt aagggcgtag ggtactgcag      180

tctggaatct acgcttgttc agactttgta ctagtttctt tgtctggcca tccgggtaac      240

ccatgccgga cgcaaaatag actactgaaa atttttttgc tttgtggttg ggactttagc      300

caagggtata aaagaccacc gtccccgaat tacctttcct cttcttttct ctctctcctt      360

gtcaactcac acccgaaatc gttaagcatt tccttctgag tataagaatc attcaaatca      420

aacgattacc caccctcgtt ttagagctag aaatagcaag ttaaaataag gctagtccgt      480

tatcaacttg aaaaagtggc accgagtcgg tggtgctttt ggccgcgtgt ggtgattgct      540

gttgtgcaag cctttgctcg ttttctgctg tatgtaattt aaagaacgat tgtatgaatc      600

gaagtcaagg tgagtgtagt ttgagaagtg taaccccagt gtcatagctg tgtactccat      660

tcattgaagg gtgtagtcgt gttttattgc atgagctcct attactcgta taagtaactg      720

ttttgtaaca cttcatgaac ggagatggta tgaacagaag taataatatc ctggaagtca      780

gctgtgccca gaggtgtgtg tgggtgtggc atactttggg acaacaacac ttgggcagta      840

tgcttagtga ccacgaagag agtgttacct tctgaggtgc gacgtgcagt agttctattg      900

tttttaaatg cgcagtcgtc tttcagaggc tgattcaagc agacgcattc agttgtgttc      960

agttgaggct gatatctcag cacctacagt ttagggaaag cagggttaag atgatgacaa     1020

ctctgggtgg taacctggga tatgcggcga tatagcaggt aatgacttaa taactgctca     1080

atgatgagta tatacatccc tcctatctat atatccatat ttagtattta catattcatc     1140

ttcaccgagc tacaagtaga aggatgtaca tgctgtatct tgcggtgcct gtcgccatgt     1200

tttcgacaag ttaagttcgg agtatgcatg caaacaaaaa tacaagtagt caaaatattg     1260

gagtatcaaa caacgtgctt cgaaatctct tccaatcgat cccc                      1304


<210>  58
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HY009

<400>  58
gtagtaagcc gggttattgg cgttc                                             25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HY010

<400>  59
atgatctgtc caatggggca tgttg                                             25


<210>  60
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  ON476

<400>  60
cctcagaagg taacactctc                                                   20


<210>  61
<211>  12054
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF617

<400>  61
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc aaaagcacca ccgactcggt gccacttttt caagttgata acggactagc     9480

cttattttaa cttgctattt ctagctctaa aacgagggtg ggtaatcgtt tgatggcaac     9540

cgattgggag agccactgtt tatatatacc ctagacaagc cccccgcttg taagatgttg     9600

gtcaatgtaa accagtatta aggttggcaa gtgcaggaga agcaaggtgt gggtaccgag     9660

caatggaaat gtgcggaagg caaaaaaatg aggccacggc ctattgtcgg ggctatatcc     9720

agggggcgat tgaagtacac taacatgaca tgtgtccaca gaccctcaat ctggcctgat     9780

gagccaaatc catacgcgct ttcgcagctc taaaggctat aacaagtcac accaccctgc     9840

tcgacctcag cgccctcact ttttgttaag acaaactgta cacgctgttc cagcgttttc     9900

tgcctgcacc tggtgggaca tttggtgcaa cctaaagtgc tcggaacctc tgtggtgtcc     9960

agatcagcgc agcagttccg aggtagtttt gaggccctta gatgatggtt taaacttaat    10020

taagtcatac acaagtcagc tttcttcgag cctcatataa gtataagtag ttcaacgtat    10080

tagcactgta cccagcatct ccgtatcgag aaacacaaca acatgcccca ttggacagat    10140

catgcggata cacaggttgt gcagtatcat acatactcga tcagacaggt cgtctgacca    10200

tcatacaagc tgaacaagcg ctccatactt gcacgctctc tatatacaca gttaaattac    10260

atatccatag tctaacctct aacagttaat cttctggtaa gcctcccagc cagccttctg    10320

gtatcgcttg gcctcctcaa taggatctcg gttctggccg tacagacctc ggccgacaat    10380

tatgatatcc gttccggtag acatgacatc ctcaacagtt cggtactgct gtccgagagc    10440

gtctcccttg tcgtcaagac ccaccccggg ggtcagaata agccagtcct cagagtcgcc    10500

cttaggtcgg ttctgggcaa tgaagccaac cacaaactcg gggtcggatc gggcaagctc    10560

aatggtctgc ttggagtact cgccagtggc cagagagccc ttgcaagaca gctcggccag    10620

catgagcaga cctctggcca gcttctcgtt gggagagggg actaggaact ccttgtactg    10680

ggagttctcg tagtcagaga cgtcctcctt cttctgttca gagacagttt cctcggcacc    10740

agctcgcagg ccagcaatga ttccggttcc gggtacaccg tgggcgttgg tgatatcgga    10800

ccactcggcg attcggtgac accggtactg gtgcttgaca gtgttgccaa tatctgcgaa    10860

ctttctgtcc tcgaacagga agaaaccgtg cttaagagca agttccttga gggggagcac    10920

agtgccggcg taggtgaagt cgtcaatgat gtcgatatgg gttttgatca tgcacacata    10980

aggtccgacc ttatcggcaa gctcaatgag ctccttggtg gtggtaacat ccagagaagc    11040

acacaggttg gttttcttgg ctgccacgag cttgagcact cgagcggcaa aggcggactt    11100

gtggacgtta gctcgagctt cgtaggaggg cattttggtg gtgaagagga gactgaaata    11160

aatttagtct gcagaacttt ttatcggaac cttatctggg gcagtgaagt atatgttatg    11220

gtaatagtta cgagttagtt gaacttatag atagactgga ctatacggct atcggtccaa    11280

attagaaaga acgtcaatgg ctctctgggc gtcgcctttg ccgacaaaaa tgtgatcatg    11340

atgaaagcca gcaatgacgt tgcagctgat attgttgtcg gccaaccgcg ccgaaaacgc    11400

agctgtcaga cccacagcct ccaacgaaga atgtatcgtc aaagtgatcc aagcacactc    11460

atagttggag tcgtactcca aaggcggcaa tgacgagtca gacagatact cgtcgacgtt    11520

taaaccatca tctaagggcc tcaaaactac ctcggaactg ctgcgctgat ctggacacca    11580

cagaggttcc gagcacttta ggttgcacca aatgtcccac caggtgcagg cagaaaacgc    11640

tggaacagcg tgtacagttt gtcttaacaa aaagtgaggg cgctgaggtc gagcagggtg    11700

gtgtgacttg ttatagcctt tagagctgcg aaagcgcgta tggatttggc tcatcaggcc    11760

agattgaggg tctgtggaca catgtcatgt tagtgtactt caatcgcccc ctggatatag    11820

ccccgacaat aggccgtggc ctcatttttt tgccttccgc acatttccat tgctcggtac    11880

ccacaccttg cttctcctgc acttgccaac cttaatactg gtttacattg accaacatct    11940

tacaagcggg gggcttgtct agggtatata taaacagtgg ctctcccaat cggttgccag    12000

tctctttttt cctttctttc cccacagatt cgaaatctaa actacacatc acac          12054


<210>  62
<211>  12121
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF616

<400>  62
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc tcccattcgc catgccgaag catgttgccc agccggcgcc agcgaggagg     9480

ctgggaccat gccggccaaa agcaccaccg actcggtgcc actttttcaa gttgataacg     9540

gactagcctt attttaactt gctatttcta gctctaaaac gagggtgggt aatcgtttga     9600

tggcaaccga ttgggagagc cactgtttat atatacccta gacaagcccc ccgcttgtaa     9660

gatgttggtc aatgtaaacc agtattaagg ttggcaagtg caggagaagc aaggtgtggg     9720

taccgagcaa tggaaatgtg cggaaggcaa aaaaatgagg ccacggccta ttgtcggggc     9780

tatatccagg gggcgattga agtacactaa catgacatgt gtccacagac cctcaatctg     9840

gcctgatgag ccaaatccat acgcgctttc gcagctctaa aggctataac aagtcacacc     9900

accctgctcg acctcagcgc cctcactttt tgttaagaca aactgtacac gctgttccag     9960

cgttttctgc ctgcacctgg tgggacattt ggtgcaacct aaagtgctcg gaacctctgt    10020

ggtgtccaga tcagcgcagc agttccgagg tagttttgag gcccttagat gatggtttaa    10080

acttaattaa gtcatacaca agtcagcttt cttcgagcct catataagta taagtagttc    10140

aacgtattag cactgtaccc agcatctccg tatcgagaaa cacaacaaca tgccccattg    10200

gacagatcat gcggatacac aggttgtgca gtatcataca tactcgatca gacaggtcgt    10260

ctgaccatca tacaagctga acaagcgctc catacttgca cgctctctat atacacagtt    10320

aaattacata tccatagtct aacctctaac agttaatctt ctggtaagcc tcccagccag    10380

ccttctggta tcgcttggcc tcctcaatag gatctcggtt ctggccgtac agacctcggc    10440

cgacaattat gatatccgtt ccggtagaca tgacatcctc aacagttcgg tactgctgtc    10500

cgagagcgtc tcccttgtcg tcaagaccca ccccgggggt cagaataagc cagtcctcag    10560

agtcgccctt aggtcggttc tgggcaatga agccaaccac aaactcgggg tcggatcggg    10620

caagctcaat ggtctgcttg gagtactcgc cagtggccag agagcccttg caagacagct    10680

cggccagcat gagcagacct ctggccagct tctcgttggg agaggggact aggaactcct    10740

tgtactggga gttctcgtag tcagagacgt cctccttctt ctgttcagag acagtttcct    10800

cggcaccagc tcgcaggcca gcaatgattc cggttccggg tacaccgtgg gcgttggtga    10860

tatcggacca ctcggcgatt cggtgacacc ggtactggtg cttgacagtg ttgccaatat    10920

ctgcgaactt tctgtcctcg aacaggaaga aaccgtgctt aagagcaagt tccttgaggg    10980

ggagcacagt gccggcgtag gtgaagtcgt caatgatgtc gatatgggtt ttgatcatgc    11040

acacataagg tccgacctta tcggcaagct caatgagctc cttggtggtg gtaacatcca    11100

gagaagcaca caggttggtt ttcttggctg ccacgagctt gagcactcga gcggcaaagg    11160

cggacttgtg gacgttagct cgagcttcgt aggagggcat tttggtggtg aagaggagac    11220

tgaaataaat ttagtctgca gaacttttta tcggaacctt atctggggca gtgaagtata    11280

tgttatggta atagttacga gttagttgaa cttatagata gactggacta tacggctatc    11340

ggtccaaatt agaaagaacg tcaatggctc tctgggcgtc gcctttgccg acaaaaatgt    11400

gatcatgatg aaagccagca atgacgttgc agctgatatt gttgtcggcc aaccgcgccg    11460

aaaacgcagc tgtcagaccc acagcctcca acgaagaatg tatcgtcaaa gtgatccaag    11520

cacactcata gttggagtcg tactccaaag gcggcaatga cgagtcagac agatactcgt    11580

cgacgtttaa accatcatct aagggcctca aaactacctc ggaactgctg cgctgatctg    11640

gacaccacag aggttccgag cactttaggt tgcaccaaat gtcccaccag gtgcaggcag    11700

aaaacgctgg aacagcgtgt acagtttgtc ttaacaaaaa gtgagggcgc tgaggtcgag    11760

cagggtggtg tgacttgtta tagcctttag agctgcgaaa gcgcgtatgg atttggctca    11820

tcaggccaga ttgagggtct gtggacacat gtcatgttag tgtacttcaa tcgccccctg    11880

gatatagccc cgacaatagg ccgtggcctc atttttttgc cttccgcaca tttccattgc    11940

tcggtaccca caccttgctt ctcctgcact tgccaacctt aatactggtt tacattgacc    12000

aacatcttac aagcgggggg cttgtctagg gtatatataa acagtggctc tcccaatcgg    12060

ttgccagtct cttttttcct ttctttcccc acagattcga aatctaaact acacatcaca    12120

c                                                                    12121


<210>  63
<211>  12110
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF619

<400>  63
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc aaaagcacca ccgactcggt gccacttttt caagttgata acggactagc     9480

cttattttaa cttgctattt ctagctctaa aacgagggtg ggtaatcgtt tgaggtgtga     9540

tgtgtagttt agatttcgaa tctgtgggga aagaaaggaa aaaagagact ggcaaccgat     9600

tgggagagcc actgtttata tataccctag acaagccccc cgcttgtaag atgttggtca     9660

atgtaaacca gtattaaggt tggcaagtgc aggagaagca aggtgtgggt accgagcaat     9720

ggaaatgtgc ggaaggcaaa aaaatgaggc cacggcctat tgtcggggct atatccaggg     9780

ggcgattgaa gtacactaac atgacatgtg tccacagacc ctcaatctgg cctgatgagc     9840

caaatccata cgcgctttcg cagctctaaa ggctataaca agtcacacca ccctgctcga     9900

cctcagcgcc ctcacttttt gttaagacaa actgtacacg ctgttccagc gttttctgcc     9960

tgcacctggt gggacatttg gtgcaaccta aagtgctcgg aacctctgtg gtgtccagat    10020

cagcgcagca gttccgaggt agttttgagg cccttagatg atggtttaaa cttaattaag    10080

tcatacacaa gtcagctttc ttcgagcctc atataagtat aagtagttca acgtattagc    10140

actgtaccca gcatctccgt atcgagaaac acaacaacat gccccattgg acagatcatg    10200

cggatacaca ggttgtgcag tatcatacat actcgatcag acaggtcgtc tgaccatcat    10260

acaagctgaa caagcgctcc atacttgcac gctctctata tacacagtta aattacatat    10320

ccatagtcta acctctaaca gttaatcttc tggtaagcct cccagccagc cttctggtat    10380

cgcttggcct cctcaatagg atctcggttc tggccgtaca gacctcggcc gacaattatg    10440

atatccgttc cggtagacat gacatcctca acagttcggt actgctgtcc gagagcgtct    10500

cccttgtcgt caagacccac cccgggggtc agaataagcc agtcctcaga gtcgccctta    10560

ggtcggttct gggcaatgaa gccaaccaca aactcggggt cggatcgggc aagctcaatg    10620

gtctgcttgg agtactcgcc agtggccaga gagcccttgc aagacagctc ggccagcatg    10680

agcagacctc tggccagctt ctcgttggga gaggggacta ggaactcctt gtactgggag    10740

ttctcgtagt cagagacgtc ctccttcttc tgttcagaga cagtttcctc ggcaccagct    10800

cgcaggccag caatgattcc ggttccgggt acaccgtggg cgttggtgat atcggaccac    10860

tcggcgattc ggtgacaccg gtactggtgc ttgacagtgt tgccaatatc tgcgaacttt    10920

ctgtcctcga acaggaagaa accgtgctta agagcaagtt ccttgagggg gagcacagtg    10980

ccggcgtagg tgaagtcgtc aatgatgtcg atatgggttt tgatcatgca cacataaggt    11040

ccgaccttat cggcaagctc aatgagctcc ttggtggtgg taacatccag agaagcacac    11100

aggttggttt tcttggctgc cacgagcttg agcactcgag cggcaaaggc ggacttgtgg    11160

acgttagctc gagcttcgta ggagggcatt ttggtggtga agaggagact gaaataaatt    11220

tagtctgcag aactttttat cggaacctta tctggggcag tgaagtatat gttatggtaa    11280

tagttacgag ttagttgaac ttatagatag actggactat acggctatcg gtccaaatta    11340

gaaagaacgt caatggctct ctgggcgtcg cctttgccga caaaaatgtg atcatgatga    11400

aagccagcaa tgacgttgca gctgatattg ttgtcggcca accgcgccga aaacgcagct    11460

gtcagaccca cagcctccaa cgaagaatgt atcgtcaaag tgatccaagc acactcatag    11520

ttggagtcgt actccaaagg cggcaatgac gagtcagaca gatactcgtc gacgtttaaa    11580

ccatcatcta agggcctcaa aactacctcg gaactgctgc gctgatctgg acaccacaga    11640

ggttccgagc actttaggtt gcaccaaatg tcccaccagg tgcaggcaga aaacgctgga    11700

acagcgtgta cagtttgtct taacaaaaag tgagggcgct gaggtcgagc agggtggtgt    11760

gacttgttat agcctttaga gctgcgaaag cgcgtatgga tttggctcat caggccagat    11820

tgagggtctg tggacacatg tcatgttagt gtacttcaat cgccccctgg atatagcccc    11880

gacaataggc cgtggcctca tttttttgcc ttccgcacat ttccattgct cggtacccac    11940

accttgcttc tcctgcactt gccaacctta atactggttt acattgacca acatcttaca    12000

agcggggggc ttgtctaggg tatatataaa cagtggctct cccaatcggt tgccagtctc    12060

ttttttcctt tctttcccca cagattcgaa atctaaacta cacatcacac               12110


<210>  64
<211>  12177
<212>  DNA
<213>  Artificial sequencce

<220>
<223>  pRF618

<400>  64
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc tcccattcgc catgccgaag catgttgccc agccggcgcc agcgaggagg     9480

ctgggaccat gccggccaaa agcaccaccg actcggtgcc actttttcaa gttgataacg     9540

gactagcctt attttaactt gctatttcta gctctaaaac gagggtgggt aatcgtttga     9600

ggtgtgatgt gtagtttaga tttcgaatct gtggggaaag aaaggaaaaa agagactggc     9660

aaccgattgg gagagccact gtttatatat accctagaca agccccccgc ttgtaagatg     9720

ttggtcaatg taaaccagta ttaaggttgg caagtgcagg agaagcaagg tgtgggtacc     9780

gagcaatgga aatgtgcgga aggcaaaaaa atgaggccac ggcctattgt cggggctata     9840

tccagggggc gattgaagta cactaacatg acatgtgtcc acagaccctc aatctggcct     9900

gatgagccaa atccatacgc gctttcgcag ctctaaaggc tataacaagt cacaccaccc     9960

tgctcgacct cagcgccctc actttttgtt aagacaaact gtacacgctg ttccagcgtt    10020

ttctgcctgc acctggtggg acatttggtg caacctaaag tgctcggaac ctctgtggtg    10080

tccagatcag cgcagcagtt ccgaggtagt tttgaggccc ttagatgatg gtttaaactt    10140

aattaagtca tacacaagtc agctttcttc gagcctcata taagtataag tagttcaacg    10200

tattagcact gtacccagca tctccgtatc gagaaacaca acaacatgcc ccattggaca    10260

gatcatgcgg atacacaggt tgtgcagtat catacatact cgatcagaca ggtcgtctga    10320

ccatcataca agctgaacaa gcgctccata cttgcacgct ctctatatac acagttaaat    10380

tacatatcca tagtctaacc tctaacagtt aatcttctgg taagcctccc agccagcctt    10440

ctggtatcgc ttggcctcct caataggatc tcggttctgg ccgtacagac ctcggccgac    10500

aattatgata tccgttccgg tagacatgac atcctcaaca gttcggtact gctgtccgag    10560

agcgtctccc ttgtcgtcaa gacccacccc gggggtcaga ataagccagt cctcagagtc    10620

gcccttaggt cggttctggg caatgaagcc aaccacaaac tcggggtcgg atcgggcaag    10680

ctcaatggtc tgcttggagt actcgccagt ggccagagag cccttgcaag acagctcggc    10740

cagcatgagc agacctctgg ccagcttctc gttgggagag gggactagga actccttgta    10800

ctgggagttc tcgtagtcag agacgtcctc cttcttctgt tcagagacag tttcctcggc    10860

accagctcgc aggccagcaa tgattccggt tccgggtaca ccgtgggcgt tggtgatatc    10920

ggaccactcg gcgattcggt gacaccggta ctggtgcttg acagtgttgc caatatctgc    10980

gaactttctg tcctcgaaca ggaagaaacc gtgcttaaga gcaagttcct tgagggggag    11040

cacagtgccg gcgtaggtga agtcgtcaat gatgtcgata tgggttttga tcatgcacac    11100

ataaggtccg accttatcgg caagctcaat gagctccttg gtggtggtaa catccagaga    11160

agcacacagg ttggttttct tggctgccac gagcttgagc actcgagcgg caaaggcgga    11220

cttgtggacg ttagctcgag cttcgtagga gggcattttg gtggtgaaga ggagactgaa    11280

ataaatttag tctgcagaac tttttatcgg aaccttatct ggggcagtga agtatatgtt    11340

atggtaatag ttacgagtta gttgaactta tagatagact ggactatacg gctatcggtc    11400

caaattagaa agaacgtcaa tggctctctg ggcgtcgcct ttgccgacaa aaatgtgatc    11460

atgatgaaag ccagcaatga cgttgcagct gatattgttg tcggccaacc gcgccgaaaa    11520

cgcagctgtc agacccacag cctccaacga agaatgtatc gtcaaagtga tccaagcaca    11580

ctcatagttg gagtcgtact ccaaaggcgg caatgacgag tcagacagat actcgtcgac    11640

gtttaaacca tcatctaagg gcctcaaaac tacctcggaa ctgctgcgct gatctggaca    11700

ccacagaggt tccgagcact ttaggttgca ccaaatgtcc caccaggtgc aggcagaaaa    11760

cgctggaaca gcgtgtacag tttgtcttaa caaaaagtga gggcgctgag gtcgagcagg    11820

gtggtgtgac ttgttatagc ctttagagct gcgaaagcgc gtatggattt ggctcatcag    11880

gccagattga gggtctgtgg acacatgtca tgttagtgta cttcaatcgc cccctggata    11940

tagccccgac aataggccgt ggcctcattt ttttgccttc cgcacatttc cattgctcgg    12000

tacccacacc ttgcttctcc tgcacttgcc aaccttaata ctggtttaca ttgaccaaca    12060

tcttacaagc ggggggcttg tctagggtat atataaacag tggctctccc aatcggttgc    12120

cagtctcttt tttcctttct ttccccacag attcgaaatc taaactacac atcacac       12177


<210>  65
<211>  11926
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF626

<400>  65
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc aaaagcacca ccgactcggt gccacttttt caagttgata acggactagc     9480

cttattttaa cttgctattt ctagctctaa aacgagggtg ggtaatcgtt tgattgacaa     9540

ggagagagag aaaagaagag gaaaggtaat tcggggacgg tggtctttta tacccttggc     9600

taaagtccca accacaaagc aaaaaaattt tcagtagtct attttgcgtc cggcatgggt     9660

tacccggatg gccagacaaa gaaactagta caaagtctga acaagcgtag attccagact     9720

gcagtaccct acgcccttaa cggcaagtgt gggaaccggg ggaggtttga tatgtgggga     9780

gaagggggct ctcgccgggg ttgggcccgc tactgggtca atttggggtc aattggggca     9840

attggggctg ttttttggga cacaaatgcg ccgccaaccc ggtctcttta attaagtcat     9900

acacaagtca gctttcttcg agcctcatat aagtataagt agttcaacgt attagcactg     9960

tacccagcat ctccgtatcg agaaacacaa caacatgccc cattggacag atcatgcgga    10020

tacacaggtt gtgcagtatc atacatactc gatcagacag gtcgtctgac catcatacaa    10080

gctgaacaag cgctccatac ttgcacgctc tctatataca cagttaaatt acatatccat    10140

agtctaacct ctaacagtta atcttctggt aagcctccca gccagccttc tggtatcgct    10200

tggcctcctc aataggatct cggttctggc cgtacagacc tcggccgaca attatgatat    10260

ccgttccggt agacatgaca tcctcaacag ttcggtactg ctgtccgaga gcgtctccct    10320

tgtcgtcaag acccaccccg ggggtcagaa taagccagtc ctcagagtcg cccttaggtc    10380

ggttctgggc aatgaagcca accacaaact cggggtcgga tcgggcaagc tcaatggtct    10440

gcttggagta ctcgccagtg gccagagagc ccttgcaaga cagctcggcc agcatgagca    10500

gacctctggc cagcttctcg ttgggagagg ggactaggaa ctccttgtac tgggagttct    10560

cgtagtcaga gacgtcctcc ttcttctgtt cagagacagt ttcctcggca ccagctcgca    10620

ggccagcaat gattccggtt ccgggtacac cgtgggcgtt ggtgatatcg gaccactcgg    10680

cgattcggtg acaccggtac tggtgcttga cagtgttgcc aatatctgcg aactttctgt    10740

cctcgaacag gaagaaaccg tgcttaagag caagttcctt gagggggagc acagtgccgg    10800

cgtaggtgaa gtcgtcaatg atgtcgatat gggttttgat catgcacaca taaggtccga    10860

ccttatcggc aagctcaatg agctccttgg tggtggtaac atccagagaa gcacacaggt    10920

tggttttctt ggctgccacg agcttgagca ctcgagcggc aaaggcggac ttgtggacgt    10980

tagctcgagc ttcgtaggag ggcattttgg tggtgaagag gagactgaaa taaatttagt    11040

ctgcagaact ttttatcgga accttatctg gggcagtgaa gtatatgtta tggtaatagt    11100

tacgagttag ttgaacttat agatagactg gactatacgg ctatcggtcc aaattagaaa    11160

gaacgtcaat ggctctctgg gcgtcgcctt tgccgacaaa aatgtgatca tgatgaaagc    11220

cagcaatgac gttgcagctg atattgttgt cggccaaccg cgccgaaaac gcagctgtca    11280

gacccacagc ctccaacgaa gaatgtatcg tcaaagtgat ccaagcacac tcatagttgg    11340

agtcgtactc caaaggcggc aatgacgagt cagacagata ctcgtcgacg tttaaaccat    11400

catctaaggg cctcaaaact acctcggaac tgctgcgctg atctggacac cacagaggtt    11460

ccgagcactt taggttgcac caaatgtccc accaggtgca ggcagaaaac gctggaacag    11520

cgtgtacagt ttgtcttaac aaaaagtgag ggcgctgagg tcgagcaggg tggtgtgact    11580

tgttatagcc tttagagctg cgaaagcgcg tatggatttg gctcatcagg ccagattgag    11640

ggtctgtgga cacatgtcat gttagtgtac ttcaatcgcc ccctggatat agccccgaca    11700

ataggccgtg gcctcatttt tttgccttcc gcacatttcc attgctcggt acccacacct    11760

tgcttctcct gcacttgcca accttaatac tggtttacat tgaccaacat cttacaagcg    11820

gggggcttgt ctagggtata tataaacagt ggctctccca atcggttgcc agtctctttt    11880

ttcctttctt tccccacaga ttcgaaatct aaactacaca tcacac                   11926


<210>  66
<211>  11993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF625

<400>  66
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc tcccattcgc catgccgaag catgttgccc agccggcgcc agcgaggagg     9480

ctgggaccat gccggccaaa agcaccaccg actcggtgcc actttttcaa gttgataacg     9540

gactagcctt attttaactt gctatttcta gctctaaaac gagggtgggt aatcgtttga     9600

ttgacaagga gagagagaaa agaagaggaa aggtaattcg gggacggtgg tcttttatac     9660

ccttggctaa agtcccaacc acaaagcaaa aaaattttca gtagtctatt ttgcgtccgg     9720

catgggttac ccggatggcc agacaaagaa actagtacaa agtctgaaca agcgtagatt     9780

ccagactgca gtaccctacg cccttaacgg caagtgtggg aaccggggga ggtttgatat     9840

gtggggagaa gggggctctc gccggggttg ggcccgctac tgggtcaatt tggggtcaat     9900

tggggcaatt ggggctgttt tttgggacac aaatgcgccg ccaacccggt ctctttaatt     9960

aagtcataca caagtcagct ttcttcgagc ctcatataag tataagtagt tcaacgtatt    10020

agcactgtac ccagcatctc cgtatcgaga aacacaacaa catgccccat tggacagatc    10080

atgcggatac acaggttgtg cagtatcata catactcgat cagacaggtc gtctgaccat    10140

catacaagct gaacaagcgc tccatacttg cacgctctct atatacacag ttaaattaca    10200

tatccatagt ctaacctcta acagttaatc ttctggtaag cctcccagcc agccttctgg    10260

tatcgcttgg cctcctcaat aggatctcgg ttctggccgt acagacctcg gccgacaatt    10320

atgatatccg ttccggtaga catgacatcc tcaacagttc ggtactgctg tccgagagcg    10380

tctcccttgt cgtcaagacc caccccgggg gtcagaataa gccagtcctc agagtcgccc    10440

ttaggtcggt tctgggcaat gaagccaacc acaaactcgg ggtcggatcg ggcaagctca    10500

atggtctgct tggagtactc gccagtggcc agagagccct tgcaagacag ctcggccagc    10560

atgagcagac ctctggccag cttctcgttg ggagagggga ctaggaactc cttgtactgg    10620

gagttctcgt agtcagagac gtcctccttc ttctgttcag agacagtttc ctcggcacca    10680

gctcgcaggc cagcaatgat tccggttccg ggtacaccgt gggcgttggt gatatcggac    10740

cactcggcga ttcggtgaca ccggtactgg tgcttgacag tgttgccaat atctgcgaac    10800

tttctgtcct cgaacaggaa gaaaccgtgc ttaagagcaa gttccttgag ggggagcaca    10860

gtgccggcgt aggtgaagtc gtcaatgatg tcgatatggg ttttgatcat gcacacataa    10920

ggtccgacct tatcggcaag ctcaatgagc tccttggtgg tggtaacatc cagagaagca    10980

cacaggttgg ttttcttggc tgccacgagc ttgagcactc gagcggcaaa ggcggacttg    11040

tggacgttag ctcgagcttc gtaggagggc attttggtgg tgaagaggag actgaaataa    11100

atttagtctg cagaactttt tatcggaacc ttatctgggg cagtgaagta tatgttatgg    11160

taatagttac gagttagttg aacttataga tagactggac tatacggcta tcggtccaaa    11220

ttagaaagaa cgtcaatggc tctctgggcg tcgcctttgc cgacaaaaat gtgatcatga    11280

tgaaagccag caatgacgtt gcagctgata ttgttgtcgg ccaaccgcgc cgaaaacgca    11340

gctgtcagac ccacagcctc caacgaagaa tgtatcgtca aagtgatcca agcacactca    11400

tagttggagt cgtactccaa aggcggcaat gacgagtcag acagatactc gtcgacgttt    11460

aaaccatcat ctaagggcct caaaactacc tcggaactgc tgcgctgatc tggacaccac    11520

agaggttccg agcactttag gttgcaccaa atgtcccacc aggtgcaggc agaaaacgct    11580

ggaacagcgt gtacagtttg tcttaacaaa aagtgagggc gctgaggtcg agcagggtgg    11640

tgtgacttgt tatagccttt agagctgcga aagcgcgtat ggatttggct catcaggcca    11700

gattgagggt ctgtggacac atgtcatgtt agtgtacttc aatcgccccc tggatatagc    11760

cccgacaata ggccgtggcc tcattttttt gccttccgca catttccatt gctcggtacc    11820

cacaccttgc ttctcctgca cttgccaacc ttaatactgg tttacattga ccaacatctt    11880

acaagcgggg ggcttgtcta gggtatatat aaacagtggc tctcccaatc ggttgccagt    11940

ctcttttttc ctttctttcc ccacagattc gaaatctaaa ctacacatca cac           11993


<210>  67
<211>  11993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRF623

<400>  67
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc tcccattcgc catgccgaag catgttgccc agccggcgcc agcgaggagg     9480

ctgggaccat gccggccaaa agcaccaccg actcggtgcc actttttcaa gttgataacg     9540

gactagcctt attttaactt gctatttcta gctctaaaac gagggtgggt aatcgtttga     9600

ttgacaagga gagagagaaa agaagaggaa aggtaattcg gggacggtgg tcttttatac     9660

ccttggctaa agtcccaacc acaaagcaaa aaaattttca gtagtctatt ttgcgtccgg     9720

catgggttac ccggatggcc agacaaagaa actagtacaa agtctgaaca agcgtagatt     9780

ccagactgca gtaccctacg cccttaacgg caagtgtggg aaccggggga ggtttgatat     9840

gtggggagaa gggggctctc gccggggttg ggcccgctac tgggtcaatt tggggtcaat     9900

tggggcaatt ggggctgttt tttgggacac aaatgcgccg ccaacccggt ctctttaatt     9960

aagtcataca caagtcagct ttcttcgagc ctcatataag tataagtagt tcaacgtatt    10020

agcactgtac ccagcatctc cgtatcgaga aacacaacaa catgccccat tggacagatc    10080

atgcggatac acaggttgtg cagtatcata catactcgat cagacaggtc gtctgaccat    10140

catacaagct gaacaagcgc tccatacttg cacgctctct atatacacag ttaaattaca    10200

tatccatagt ctaacctcta acagttaatc ttctggtaag cctcccagcc agccttctgg    10260

tatcgcttgg cctcctcaat aggatctcgg ttctggccgt acagacctcg gccgacaatt    10320

atgatatccg ttccggtaga catgacatcc tcaacagttc ggtactgctg tccgagagcg    10380

tctcccttgt cgtcaagacc caccccgggg gtcagaataa gccagtcctc agagtcgccc    10440

ttaggtcggt tctgggcaat gaagccaacc acaaactcgg ggtcggatcg ggcaagctca    10500

atggtctgct tggagtactc gccagtggcc agagagccct tgcaagacag ctcggccagc    10560

atgagcagac ctctggccag cttctcgttg ggagagggga ctaggaactc cttgtactgg    10620

gagttctcgt agtcagagac gtcctccttc ttctgttcag agacagtttc ctcggcacca    10680

gctcgcaggc cagcaatgat tccggttccg ggtacaccgt gggcgttggt gatatcggac    10740

cactcggcga ttcggtgaca ccggtactgg tgcttgacag tgttgccaat atctgcgaac    10800

tttctgtcct cgaacaggaa gaaaccgtgc ttaagagcaa gttccttgag ggggagcaca    10860

gtgccggcgt aggtgaagtc gtcaatgatg tcgatatggg ttttgatcat gcacacataa    10920

ggtccgacct tatcggcaag ctcaatgagc tccttggtgg tggtaacatc cagagaagca    10980

cacaggttgg ttttcttggc tgccacgagc ttgagcactc gagcggcaaa ggcggacttg    11040

tggacgttag ctcgagcttc gtaggagggc attttggtgg tgaagaggag actgaaataa    11100

atttagtctg cagaactttt tatcggaacc ttatctgggg cagtgaagta tatgttatgg    11160

taatagttac gagttagttg aacttataga tagactggac tatacggcta tcggtccaaa    11220

ttagaaagaa cgtcaatggc tctctgggcg tcgcctttgc cgacaaaaat gtgatcatga    11280

tgaaagccag caatgacgtt gcagctgata ttgttgtcgg ccaaccgcgc cgaaaacgca    11340

gctgtcagac ccacagcctc caacgaagaa tgtatcgtca aagtgatcca agcacactca    11400

tagttggagt cgtactccaa aggcggcaat gacgagtcag acagatactc gtcgacgttt    11460

aaaccatcat ctaagggcct caaaactacc tcggaactgc tgcgctgatc tggacaccac    11520

agaggttccg agcactttag gttgcaccaa atgtcccacc aggtgcaggc agaaaacgct    11580

ggaacagcgt gtacagtttg tcttaacaaa aagtgagggc gctgaggtcg agcagggtgg    11640

tgtgacttgt tatagccttt agagctgcga aagcgcgtat ggatttggct catcaggcca    11700

gattgagggt ctgtggacac atgtcatgtt agtgtacttc aatcgccccc tggatatagc    11760

cccgacaata ggccgtggcc tcattttttt gccttccgca catttccatt gctcggtacc    11820

cacaccttgc ttctcctgca cttgccaacc ttaatactgg tttacattga ccaacatctt    11880

acaagcgggg ggcttgtcta gggtatatat aaacagtggc tctcccaatc ggttgccagt    11940

ctcttttttc ctttctttcc ccacagattc gaaatctaaa ctacacatca cac           11993


<210>  68
<211>  12045
<212>  DNA
<213>  artificial sequence

<220>
<223>  pRF621

<400>  68
catggacaag aaatactcca tcggcctgga cattggaacc aactctgtcg gctgggctgt       60

catcaccgac gagtacaagg tgccctccaa gaaattcaag gtcctcggaa acaccgatcg      120

acactccatc aagaaaaacc tcattggtgc cctgttgttc gattctggcg agactgccga      180

agctaccaga ctcaagcgaa ctgctcggcg acgttacacc cgacggaaga accgaatctg      240

ctacctgcag gagatctttt ccaacgagat ggccaaggtg gacgattcgt tctttcatcg      300

actggaggaa tccttcctcg tcgaggaaga caagaaacac gagcgtcatc ccatctttgg      360

caacattgtg gacgaggttg cttaccacga gaagtatcct accatctacc acctgcgaaa      420

gaaactcgtc gattccaccg acaaggcgga tctcagactt atctacctcg ctctggcaca      480

catgatcaag tttcgaggtc atttcctcat cgagggcgat ctcaatcccg acaacagcga      540

tgtggacaag ctgttcattc agctcgttca gacctacaac cagctgttcg aggaaaaccc      600

catcaatgcc tccggagtcg atgcaaaggc catcttgtct gctcgactct cgaagagcag      660

acgactggag aacctcattg cccaacttcc tggcgagaaa aagaacggac tgtttggcaa      720

cctcattgcc ctttctcttg gtctcacacc caacttcaag tccaacttcg atctggcgga      780

ggacgccaag ctccagctgt ccaaggacac ctacgacgat gacctcgaca acctgcttgc      840

acagattggc gatcagtacg ccgacctgtt tctcgctgcc aagaaccttt cggatgctat      900

tctcttgtct gacattctgc gagtcaacac cgagatcaca aaggctcccc tttctgcctc      960

catgatcaag cgatacgacg agcaccatca ggatctcaca ctgctcaagg ctcttgtccg     1020

acagcaactg cccgagaagt acaaggagat ctttttcgat cagtcgaaga acggctacgc     1080

tggatacatc gacggcggag cctctcagga agagttctac aagttcatca agccaattct     1140

cgagaagatg gacggaaccg aggaactgct tgtcaagctc aatcgagagg atctgcttcg     1200

gaagcaacga accttcgaca acggcagcat tcctcatcag atccacctcg gtgagctgca     1260

cgccattctt cgacgtcagg aagacttcta cccctttctc aaggacaacc gagagaagat     1320

cgagaagatt cttacctttc gaatccccta ctatgttggt cctcttgcca gaggaaactc     1380

tcgatttgct tggatgactc gaaagtccga ggaaaccatc actccctgga acttcgagga     1440

agtcgtggac aagggtgcct ctgcacagtc cttcatcgag cgaatgacca acttcgacaa     1500

gaatctgccc aacgagaagg ttcttcccaa gcattcgctg ctctacgagt actttacagt     1560

ctacaacgaa ctcaccaaag tcaagtacgt taccgaggga atgcgaaagc ctgccttctt     1620

gtctggcgaa cagaagaaag ccattgtcga tctcctgttc aagaccaacc gaaaggtcac     1680

tgttaagcag ctcaaggagg actacttcaa gaaaatcgag tgtttcgaca gcgtcgagat     1740

ttccggagtt gaggaccgat tcaacgcctc tttgggcacc tatcacgatc tgctcaagat     1800

tatcaaggac aaggattttc tcgacaacga ggaaaacgag gacattctgg aggacatcgt     1860

gctcactctt accctgttcg aagatcggga gatgatcgag gaacgactca agacatacgc     1920

tcacctgttc gacgacaagg tcatgaaaca actcaagcga cgtagataca ccggctgggg     1980

aagactttcg cgaaagctca tcaacggcat cagagacaag cagtccggaa agaccattct     2040

ggactttctc aagtccgatg gctttgccaa ccgaaacttc atgcagctca ttcacgacga     2100

ttctcttacc ttcaaggagg acatccagaa ggcacaagtg tccggtcagg gcgacagctt     2160

gcacgaacat attgccaacc tggctggttc gccagccatc aagaaaggca ttctccagac     2220

tgtcaaggtt gtcgacgagc tggtgaaggt catgggacgt cacaagcccg agaacattgt     2280

gatcgagatg gccagagaga accagacaac tcaaaagggt cagaaaaact cgcgagagcg     2340

gatgaagcga atcgaggaag gcatcaagga gctgggatcc cagattctca aggagcatcc     2400

cgtcgagaac actcaactgc agaacgagaa gctgtatctc tactatctgc agaatggtcg     2460

agacatgtac gtggatcagg aactggacat caatcgtctc agcgactacg atgtggacca     2520

cattgtccct caatcctttc tcaaggacga ttctatcgac aacaaggtcc ttacacgatc     2580

cgacaagaac agaggcaagt cggacaacgt tcccagcgaa gaggtggtca aaaagatgaa     2640

gaactactgg cgacagctgc tcaacgccaa gctcattacc cagcgaaagt tcgacaatct     2700

taccaaggcc gagcgaggcg gtctgtccga gctcgacaag gctggcttca tcaagcgtca     2760

actcgtcgag accagacaga tcacaaagca cgtcgcacag attctcgatt ctcggatgaa     2820

caccaagtac gacgagaacg acaagctcat ccgagaggtc aaggtgatta ctctcaagtc     2880

caaactggtc tccgatttcc gaaaggactt tcagttctac aaggtgcgag agatcaacaa     2940

ttaccaccat gcccacgatg cttacctcaa cgccgtcgtt ggcactgcgc tcatcaagaa     3000

ataccccaag ctcgaaagcg agttcgttta cggcgattac aaggtctacg acgttcgaaa     3060

gatgattgcc aagtccgaac aggagattgg caaggctact gccaagtact tcttttactc     3120

caacatcatg aactttttca agaccgagat caccttggcc aacggagaga ttcgaaagag     3180

accacttatc gagaccaacg gcgaaactgg agagatcgtg tgggacaagg gtcgagactt     3240

tgcaaccgtg cgaaaggttc tgtcgatgcc tcaggtcaac atcgtcaaga aaaccgaggt     3300

tcagactggc ggattctcca aggagtcgat tctgcccaag cgaaactccg acaagctcat     3360

cgctcgaaag aaagactggg atcccaagaa atacggtggc ttcgattctc ctaccgtcgc     3420

ctattccgtg cttgtcgttg cgaaggtcga gaagggcaag tccaaaaagc tcaagtccgt     3480

caaggagctg ctcggaatta ccatcatgga gcgatcgagc ttcgagaaga atcccatcga     3540

cttcttggaa gccaagggtt acaaggaggt caagaaagac ctcattatca agctgcccaa     3600

gtactctctg ttcgaactgg agaacggtcg aaagcgtatg ctcgcctccg ctggcgagct     3660

gcagaaggga aacgagcttg ccttgccttc gaagtacgtc aactttctct atctggcttc     3720

tcactacgag aagctcaagg gttctcccga ggacaacgaa cagaagcaac tcttcgttga     3780

gcagcacaaa cattacctcg acgagattat cgagcagatt tccgagtttt cgaagcgagt     3840

catcctggct gatgccaact tggacaaggt gctctctgcc tacaacaagc atcgggacaa     3900

acccattcga gaacaggcgg agaacatcat tcacctgttt actcttacca acctgggtgc     3960

tcctgcagct ttcaagtact tcgataccac tatcgaccga aagcggtaca catccaccaa     4020

ggaggttctc gatgccaccc tgattcacca gtccatcact ggcctgtacg agacccgaat     4080

cgacctgtct cagcttggtg gcgactccag agccgatccc aagaaaaagc gaaaggtcta     4140

agcggccgca agtgtggatg gggaagtgag tgcccggttc tgtgtgcaca attggcaatc     4200

caagatggat ggattcaaca cagggatata gcgagctacg tggtggtgcg aggatatagc     4260

aacggatatt tatgtttgac acttgagaat gtacgataca agcactgtcc aagtacaata     4320

ctaaacatac tgtacatact catactcgta cccgggcaac ggtttcactt gagtgcagtg     4380

gctagtgctc ttactcgtac agtgtgcaat actgcgtatc atagtctttg atgtatatcg     4440

tattcattca tgttagttgc gtacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4500

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4560

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4620

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4680

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4740

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4800

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4860

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4920

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4980

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5040

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5100

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5160

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5220

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5280

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5340

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5400

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5460

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5520

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5580

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5640

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5700

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5760

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5820

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5880

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5940

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6000

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6060

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6120

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6180

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6240

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6300

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6360

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6420

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6480

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6540

ttccccgaaa agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     6600

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     6660

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     6720

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     6780

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     6840

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     6900

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     6960

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca     7020

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     7080

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     7140

ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact cactataggg     7200

cgaattgggt accgggcccc ccctcgaggt cgatggtgtc gataagcttg atatcgaatt     7260

catgtcacac aaaccgatct tcgcctcaag gaaacctaat tctacatccg agagactgcc     7320

gagatccagt ctacactgat taattttcgg gccaataatt taaaaaaatc gtgttatata     7380

atattatatg tattatatat atacatcatg atgatactga cagtcatgtc ccattgctaa     7440

atagacagac tccatctgcc gcctccaact gatgttctca atatttaagg ggtcatctcg     7500

cattgtttaa taataaacag actccatcta ccgcctccaa atgatgttct caaaatatat     7560

tgtatgaact tatttttatt acttagtatt attagacaac ttacttgctt tatgaaaaac     7620

acttcctatt taggaaacaa tttataatgg cagttcgttc atttaacaat ttatgtagaa     7680

taaatgttat aaatgcgtat gggaaatctt aaatatggat agcataaatg atatctgcat     7740

tgcctaattc gaaatcaaca gcaacgaaaa aaatcccttg tacaacataa atagtcatcg     7800

agaaatatca actatcaaag aacagctatt cacacgttac tattgagatt attattggac     7860

gagaatcaca cactcaactg tctttctctc ttctagaaat acaggtacaa gtatgtacta     7920

ttctcattgt tcatacttct agtcatttca tcccacatat tccttggatt tctctccaat     7980

gaatgacatt ctatcttgca aattcaacaa ttataataag atataccaaa gtagcggtat     8040

agtggcaatc aaaaagcttc tctggtgtgc ttctcgtatt tatttttatt ctaatgatcc     8100

attaaaggta tatatttatt tcttgttata taatcctttt gtttattaca tgggctggat     8160

acataaaggt attttgattt aattttttgc ttaaattcaa tcccccctcg ttcagtgtca     8220

actgtaatgg taggaaatta ccatactttt gaagaagcaa aaaaaatgaa agaaaaaaaa     8280

aatcgtattt ccaggttaga cgttccgcag aatctagaat gcggtatgcg gtacattgtt     8340

cttcgaacgt aaaagttgcg ctccctgaga tattgtacat ttttgctttt acaagtacaa     8400

gtacatcgta caactatgta ctactgttga tgcatccaca acagtttgtt ttgttttttt     8460

ttgttttttt tttttctaat gattcattac cgctatgtat acctacttgt acttgtagta     8520

agccgggtta ttggcgttca attaatcata gacttatgaa tctgcacggt gtgcgctgcg     8580

agttactttt agcttatgca tgctacttgg gtgtaatatt gggatctgtt cggaaatcaa     8640

cggatgctca atcgattgga agagatttcg aagcacgttg tttgatactc caatattttg     8700

actacttgta tttttgtttg catgcatact ccgaacttaa cttgtcgaaa acatggcgac     8760

aggcaccgca agatacagca tgtacatcct tctacttgta gctcggtgaa gatgaatatg     8820

taaatactaa atatggatat atagatagga gggatgtata tactcatcat tgagcagtta     8880

ttaagtcatt acctgctata tcgccgcata tcccaggtta ccacccagag ttgtcatcat     8940

cttaaccctg ctttccctaa actgtaggtg ctgagatatc agcctcaact gaacacaact     9000

gaatgcgtct gcttgaatca gcctctgaaa gacgactgcg catttaaaaa caatagaact     9060

actgcacgtc gcacctcaga aggtaacact ctcttcgtgg tcactaagca tactgcccaa     9120

gtgttgttgt cccaaagtat gccacaccca cacacacctc tgggcacagc tgacttccag     9180

gatattatta cttctgttca taccatctcc gttcatgaag tgttacaaaa cagttactta     9240

tacgagtaat aggagctcat gcaataaaac acgactacac ccttcaatga atggagtaca     9300

cagctatgac actggggtta cacttctcaa actacactca ccttgacttc gattcataca     9360

atcgttcttt aaattacata cagcagaaaa cgagcaaagg cttgcacaac agcaatcacc     9420

acacgcggcc tcccattcgc catgccgaag catgttgccc agccggcgcc agcgaggagg     9480

ctgggaccat gccggccaaa agcaccaccg actcggtgcc actttttcaa gttgataacg     9540

gactagcctt attttaactt gctatttcta gctctaaaac gagggtgggt aatcgtttga     9600

tttgaatgat tcttatactc agaaggaaat gcttaacgat ttcgggtgtg agttgacaag     9660

gagagagaga aaagaagagg aaaggtaatt cggggacggt ggtcttttat acccttggct     9720

aaagtcccaa ccacaaagca aaaaaatttt cagtagtcta ttttgcgtcc ggcatgggtt     9780

acccggatgg ccagacaaag aaactagtac aaagtctgaa caagcgtaga ttccagactg     9840

cagtacccta cgcccttaac ggcaagtgtg ggaaccgggg gaggtttgat atgtggggag     9900

aagggggctc tcgccggggt tgggcccgct actgggtcaa tttggggtca attggggcaa     9960

ttggggctgt tttttgggac acaaatgcgc cgccaacccg gtctctttaa ttaagtcata    10020

cacaagtcag ctttcttcga gcctcatata agtataagta gttcaacgta ttagcactgt    10080

acccagcatc tccgtatcga gaaacacaac aacatgcccc attggacaga tcatgcggat    10140

acacaggttg tgcagtatca tacatactcg atcagacagg tcgtctgacc atcatacaag    10200

ctgaacaagc gctccatact tgcacgctct ctatatacac agttaaatta catatccata    10260

gtctaacctc taacagttaa tcttctggta agcctcccag ccagccttct ggtatcgctt    10320

ggcctcctca ataggatctc ggttctggcc gtacagacct cggccgacaa ttatgatatc    10380

cgttccggta gacatgacat cctcaacagt tcggtactgc tgtccgagag cgtctccctt    10440

gtcgtcaaga cccaccccgg gggtcagaat aagccagtcc tcagagtcgc ccttaggtcg    10500

gttctgggca atgaagccaa ccacaaactc ggggtcggat cgggcaagct caatggtctg    10560

cttggagtac tcgccagtgg ccagagagcc cttgcaagac agctcggcca gcatgagcag    10620

acctctggcc agcttctcgt tgggagaggg gactaggaac tccttgtact gggagttctc    10680

gtagtcagag acgtcctcct tcttctgttc agagacagtt tcctcggcac cagctcgcag    10740

gccagcaatg attccggttc cgggtacacc gtgggcgttg gtgatatcgg accactcggc    10800

gattcggtga caccggtact ggtgcttgac agtgttgcca atatctgcga actttctgtc    10860

ctcgaacagg aagaaaccgt gcttaagagc aagttccttg agggggagca cagtgccggc    10920

gtaggtgaag tcgtcaatga tgtcgatatg ggttttgatc atgcacacat aaggtccgac    10980

cttatcggca agctcaatga gctccttggt ggtggtaaca tccagagaag cacacaggtt    11040

ggttttcttg gctgccacga gcttgagcac tcgagcggca aaggcggact tgtggacgtt    11100

agctcgagct tcgtaggagg gcattttggt ggtgaagagg agactgaaat aaatttagtc    11160

tgcagaactt tttatcggaa ccttatctgg ggcagtgaag tatatgttat ggtaatagtt    11220

acgagttagt tgaacttata gatagactgg actatacggc tatcggtcca aattagaaag    11280

aacgtcaatg gctctctggg cgtcgccttt gccgacaaaa atgtgatcat gatgaaagcc    11340

agcaatgacg ttgcagctga tattgttgtc ggccaaccgc gccgaaaacg cagctgtcag    11400

acccacagcc tccaacgaag aatgtatcgt caaagtgatc caagcacact catagttgga    11460

gtcgtactcc aaaggcggca atgacgagtc agacagatac tcgtcgacgt ttaaaccatc    11520

atctaagggc ctcaaaacta cctcggaact gctgcgctga tctggacacc acagaggttc    11580

cgagcacttt aggttgcacc aaatgtccca ccaggtgcag gcagaaaacg ctggaacagc    11640

gtgtacagtt tgtcttaaca aaaagtgagg gcgctgaggt cgagcagggt ggtgtgactt    11700

gttatagcct ttagagctgc gaaagcgcgt atggatttgg ctcatcaggc cagattgagg    11760

gtctgtggac acatgtcatg ttagtgtact tcaatcgccc cctggatata gccccgacaa    11820

taggccgtgg cctcattttt ttgccttccg cacatttcca ttgctcggta cccacacctt    11880

gcttctcctg cacttgccaa ccttaatact ggtttacatt gaccaacatc ttacaagcgg    11940

ggggcttgtc tagggtatat ataaacagtg gctctcccaa tcggttgcca gtctcttttt    12000

tcctttcttt ccccacagat tcgaaatcta aactacacat cacac                    12045


<210>  69
<211>  23
<212>  DNA
<213>  Yarrowia lipolytica

<400>  69
tcaaacgatt acccaccctc cgg                                               23


<210>  70
<211>  11176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pRF303

<400>  70
tctaaaacga gggtgggtaa tcgtttgagt cccattcgcc atgccgaagc atgttgccca       60

gccggcgcca gcgaggaggc tgggaccatg ccggccatta ttttgcgtta agtttctaat      120

catcacgaaa ttatctatca aaaataacta ggtcccaccg agattcgaac tcgggacctt      180

aagatttgca atctcacgcg ctaccgctgt gccataggac cgaagttaaa atttggccaa      240

agaaggacct gggcaccctg gactgtgggt tagggtaata ttccttatgg agacaatggg      300

ctagggtaaa ttacctaaaa tgggtcgata aagaggggtg ttcccagttg ggaagtgtaa      360

ttgaagacgg ggtcaaaaaa gaaaatcaaa aaaaatttaa ttaagtcata cacaagtcag      420

ctttcttcga gcctcatata agtataagta gttcaacgta ttagcactgt acccagcatc      480

tccgtatcga gaaacacaac aacatgcccc attggacaga tcatgcggat acacaggttg      540

tgcagtatca tacatactcg atcagacagg tcgtctgacc atcatacaag ctgaacaagc      600

gctccatact tgcacgctct ctatatacac agttaaatta catatccata gtctaacctc      660

taacagttaa tcttctggta agcctcccag ccagccttct ggtatcgctt ggcctcctca      720

ataggatctc ggttctggcc gtacagacct cggccgacaa ttatgatatc cgttccggta      780

gacatgacat cctcaacagt tcggtactgc tgtccgagag cgtctccctt gtcgtcaaga      840

cccaccccgg gggtcagaat aagccagtcc tcagagtcgc ccttaggtcg gttctgggca      900

atgaagccaa ccacaaactc ggggtcggat cgggcaagct caatggtctg cttggagtac      960

tcgccagtgg ccagagagcc cttgcaagac agctcggcca gcatgagcag acctctggcc     1020

agcttctcgt tgggagaggg gactaggaac tccttgtact gggagttctc gtagtcagag     1080

acgtcctcct tcttctgttc agagacagtt tcctcggcac cagctcgcag gccagcaatg     1140

attccggttc cgggtacacc gtgggcgttg gtgatatcgg accactcggc gattcggtga     1200

caccggtact ggtgcttgac agtgttgcca atatctgcga actttctgtc ctcgaacagg     1260

aagaaaccgt gcttaagagc aagttccttg agggggagca cagtgccggc gtaggtgaag     1320

tcgtcaatga tgtcgatatg ggttttgatc atgcacacat aaggtccgac cttatcggca     1380

agctcaatga gctccttggt ggtggtaaca tccagagaag cacacaggtt ggttttcttg     1440

gctgccacga gcttgagcac tcgagcggca aaggcggact tgtggacgtt agctcgagct     1500

tcgtaggagg gcattttggt ggtgaagagg agactgaaat aaatttagtc tgcagaactt     1560

tttatcggaa ccttatctgg ggcagtgaag tatatgttat ggtaatagtt acgagttagt     1620

tgaacttata gatagactgg actatacggc tatcggtcca aattagaaag aacgtcaatg     1680

gctctctggg cgtcgccttt gccgacaaaa atgtgatcat gatgaaagcc agcaatgacg     1740

ttgcagctga tattgttgtc ggccaaccgc gccgaaaacg cagctgtcag acccacagcc     1800

tccaacgaag aatgtatcgt caaagtgatc caagcacact catagttgga gtcgtactcc     1860

aaaggcggca atgacgagtc agacagatac tcgtcgacgt ttaaaccatc atctaagggc     1920

ctcaaaacta cctcggaact gctgcgctga tctggacacc acagaggttc cgagcacttt     1980

aggttgcacc aaatgtccca ccaggtgcag gcagaaaacg ctggaacagc gtgtacagtt     2040

tgtcttaaca aaaagtgagg gcgctgaggt cgagcagggt ggtgtgactt gttatagcct     2100

ttagagctgc gaaagcgcgt atggatttgg ctcatcaggc cagattgagg gtctgtggac     2160

acatgtcatg ttagtgtact tcaatcgccc cctggatata gccccgacaa taggccgtgg     2220

cctcattttt ttgccttccg cacatttcca ttgctcggta cccacacctt gcttctcctg     2280

cacttgccaa ccttaatact ggtttacatt gaccaacatc ttacaagcgg ggggcttgtc     2340

tagggtatat ataaacagtg gctctcccaa tcggttgcca gtctcttttt tcctttcttt     2400

ccccacagat tcgaaatcta aactacacat cacaccatgg acaagaaata ctccatcggc     2460

ctggacattg gaaccaactc tgtcggctgg gctgtcatca ccgacgagta caaggtgccc     2520

tccaagaaat tcaaggtcct cggaaacacc gatcgacact ccatcaagaa aaacctcatt     2580

ggtgccctgt tgttcgattc tggcgagact gccgaagcta ccagactcaa gcgaactgct     2640

cggcgacgtt acacccgacg gaagaaccga atctgctacc tgcaggagat cttttccaac     2700

gagatggcca aggtggacga ttcgttcttt catcgactgg aggaatcctt cctcgtcgag     2760

gaagacaaga aacacgagcg tcatcccatc tttggcaaca ttgtggacga ggttgcttac     2820

cacgagaagt atcctaccat ctaccatctc cgaaagaaac tcgtcgattc caccgacaag     2880

gcggatctca gacttatcta cctcgctctg gcacacatga tcaagtttcg aggtcatttc     2940

ctcatcgagg gcgatctcaa tcccgacaac agcgatgtgg acaagctgtt cattcagctc     3000

gttcagacct acaaccagct gttcgaggaa aaccccatca atgcctccgg agtcgatgca     3060

aaggccatct tgtctgctcg actctcgaag agcagacgac tggagaacct cattgcccaa     3120

cttcctggcg agaaaaagaa cggactgttt ggcaacctca ttgccctttc tcttggtctc     3180

acacccaact tcaagtccaa cttcgatctg gcggaggacg ccaagctcca gctgtccaag     3240

gacacctacg acgatgacct cgacaacctg cttgcacaga ttggcgatca gtacgccgac     3300

ctgtttctcg ctgccaagaa cctttcggat gctattctct tgtctgacat tctgcgagtc     3360

aacaccgaga tcacaaaggc tcccctttct gcctccatga tcaagcgata cgacgagcac     3420

catcaggatc tcacactgct caaggctctt gtccgacagc aactgcccga gaagtacaag     3480

gagatctttt tcgatcagtc gaagaacggc tacgctggat acatcgacgg cggagcctct     3540

caggaagagt tctacaagtt catcaagcca attctcgaga agatggacgg aaccgaggaa     3600

ctgcttgtca agctcaatcg agaggatctg cttcggaagc aacgaacctt cgacaacggc     3660

agcattcctc atcagatcca cctcggtgag ctgcacgcca ttcttcgacg tcaggaagac     3720

ttctacccct ttctcaagga caaccgagag aagatcgaga agattcttac ctttcgaatc     3780

ccctactatg ttggtcctct tgccagagga aactctcgat ttgcttggat gactcgaaag     3840

tccgaggaaa ccatcactcc ctggaacttc gaggaagtcg tggacaaggg tgcctctgca     3900

cagtccttca tcgagcgaat gaccaacttc gacaagaatc tgcccaacga gaaggttctt     3960

cccaagcatt cgctgctcta cgagtacttt acagtctaca acgaactcac caaagtcaag     4020

tacgttaccg agggaatgcg aaagcctgcc ttcttgtctg gcgaacagaa gaaagccatt     4080

gtcgatctcc tgttcaagac caaccgaaag gtcactgtta agcagctcaa ggaggactac     4140

ttcaagaaaa tcgagtgttt cgacagcgtc gagatttccg gagttgagga ccgattcaac     4200

gcctctttgg gcacctatca cgatctgctc aagattatca aggacaagga ttttctcgac     4260

aacgaggaaa acgaggacat tctggaggac atcgtgctca ctcttaccct gttcgaagat     4320

cgggagatga tcgaggaacg actcaagaca tacgctcacc tgttcgacga caaggtcatg     4380

aaacaactca agcgacgtag atacaccggc tggggaagac tttcgcgaaa gctcatcaac     4440

ggcatcagag acaagcagtc cggaaagacc attctggact ttctcaagtc cgatggcttt     4500

gccaaccgaa acttcatgca gctcattcac gacgattctc ttaccttcaa ggaggacatc     4560

cagaaggcac aagtgtccgg tcagggcgac agcttgcacg aacatattgc caacctggct     4620

ggttcgccag ccatcaagaa aggcattctc cagactgtca aggttgtcga cgagctggtg     4680

aaggtcatgg gacgtcacaa gcccgagaac attgtgatcg agatggccag agagaaccag     4740

acaactcaaa agggtcagaa aaactcgcga gagcggatga agcgaatcga ggaaggcatc     4800

aaggagctgg gatcccagat tctcaaggag catcccgtcg agaacactca actgcagaac     4860

gagaagctgt atctctacta tctgcagaat ggtcgagaca tgtacgtgga tcaggaactg     4920

gacatcaatc gtctcagcga ctacgatgtg gaccacattg tccctcaatc ctttctcaag     4980

gacgattcta tcgacaacaa ggtccttaca cgatccgaca agaacagagg caagtcggac     5040

aacgttccca gcgaagaggt ggtcaaaaag atgaagaact actggcgaca gctgctcaac     5100

gccaagctca ttacccagcg aaagttcgac aatcttacca aggccgagcg aggcggtctg     5160

tccgagctcg acaaggctgg cttcatcaag cgtcaactcg tcgagaccag acagatcaca     5220

aagcacgtcg cacagattct cgattctcgg atgaacacca agtacgacga gaacgacaag     5280

ctcatccgag aggtcaaggt gattactctc aagtccaaac tggtctccga tttccgaaag     5340

gactttcagt tctacaaggt gcgagagatc aacaattacc accatgccca cgatgcttac     5400

ctcaacgccg tcgttggcac tgcgctcatc aagaaatacc ccaagctcga aagcgagttc     5460

gtttacggcg attacaaggt ctacgacgtt cgaaagatga ttgccaagtc cgaacaggag     5520

attggcaagg ctactgccaa gtacttcttt tactccaaca tcatgaactt tttcaagacc     5580

gagatcacct tggccaacgg agagattcga aagagaccac ttatcgagac caacggcgaa     5640

actggagaga tcgtgtggga caagggtcga gactttgcaa ccgtgcgaaa ggttctgtcg     5700

atgcctcagg tcaacatcgt caagaaaacc gaggttcaga ctggcggatt ctccaaggag     5760

tcgattctgc ccaagcgaaa ctccgacaag ctcatcgctc gaaagaaaga ctgggatccc     5820

aagaaatacg gtggcttcga ttctcctacc gtcgcctatt ccgtgcttgt cgttgcgaag     5880

gtcgagaagg gcaagtccaa aaagctcaag tccgtcaagg agctgctcgg aattaccatc     5940

atggagcgat cgagcttcga gaagaatccc atcgacttct tggaagccaa gggttacaag     6000

gaggtcaaga aagacctcat tatcaagctg cccaagtact ctctgttcga actggagaac     6060

ggtcgaaagc gtatgctcgc ctccgctggc gagctgcaga agggaaacga gcttgccttg     6120

ccttcgaagt acgtcaactt tctctatctg gcttctcact acgagaagct caagggttct     6180

cccgaggaca acgaacagaa gcaactcttc gttgagcagc acaaacatta cctcgacgag     6240

attatcgagc agatttccga gttttcgaag cgagtcatcc tggctgatgc caacttggac     6300

aaggtgctct ctgcctacaa caagcatcgg gacaaaccca ttcgagaaca ggcggagaac     6360

atcattcacc tgtttactct taccaacctg ggtgctcctg cagctttcaa gtacttcgat     6420

accactatcg accgaaagcg gtacacatcc accaaggagg ttctcgatgc caccctgatt     6480

caccagtcca tcactggcct gtacgagacc cgaatcgacc tgtctcagct tggtggcgac     6540

tccagagccg atcccaagaa aaagcgaaag gtctaagcgg ccgcaagtgt ggatggggaa     6600

gtgagtgccc ggttctgtgt gcacaattgg caatccaaga tggatggatt caacacaggg     6660

atatagcgag ctacgtggtg gtgcgaggat atagcaacgg atatttatgt ttgacacttg     6720

agaatgtacg atacaagcac tgtccaagta caatactaaa catactgtac atactcatac     6780

tcgtacccgg gcaacggttt cacttgagtg cagtggctag tgctcttact cgtacagtgt     6840

gcaatactgc gtatcatagt ctttgatgta tatcgtattc attcatgtta gttgcgtacg     6900

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     6960

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     7020

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     7080

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     7140

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     7200

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     7260

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     7320

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     7380

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     7440

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     7500

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     7560

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     7620

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     7680

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     7740

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     7800

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     7860

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     7920

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     7980

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     8040

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     8100

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     8160

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     8220

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     8280

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     8340

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     8400

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     8460

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     8520

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     8580

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     8640

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     8700

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     8760

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     8820

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     8880

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     8940

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgc     9000

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     9060

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     9120

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     9180

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc     9240

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     9300

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg     9360

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc     9420

gaattttaac aaaatattaa cgcttacaat ttccattcgc cattcaggct gcgcaactgt     9480

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     9540

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     9600

acggccagtg aattgtaata cgactcacta tagggcgaat tgggtaccgg gccccccctc     9660

gaggtcgatg gtgtcgataa gcttgatatc gaattcatgt cacacaaacc gatcttcgcc     9720

tcaaggaaac ctaattctac atccgagaga ctgccgagat ccagtctaca ctgattaatt     9780

ttcgggccaa taatttaaaa aaatcgtgtt atataatatt atatgtatta tatatataca     9840

tcatgatgat actgacagtc atgtcccatt gctaaataga cagactccat ctgccgcctc     9900

caactgatgt tctcaatatt taaggggtca tctcgcattg tttaataata aacagactcc     9960

atctaccgcc tccaaatgat gttctcaaaa tatattgtat gaacttattt ttattactta    10020

gtattattag acaacttact tgctttatga aaaacacttc ctatttagga aacaatttat    10080

aatggcagtt cgttcattta acaatttatg tagaataaat gttataaatg cgtatgggaa    10140

atcttaaata tggatagcat aaatgatatc tgcattgcct aattcgaaat caacagcaac    10200

gaaaaaaatc ccttgtacaa cataaatagt catcgagaaa tatcaactat caaagaacag    10260

ctattcacac gttactattg agattattat tggacgagaa tcacacactc aactgtcttt    10320

ctctcttcta gaaatacagg tacaagtatg tactattctc attgttcata cttctagtca    10380

tttcatccca catattcctt ggatttctct ccaatgaatg acattctatc ttgcaaattc    10440

aacaattata ataagatata ccaaagtagc ggtatagtgg caatcaaaaa gcttctctgg    10500

tgtgcttctc gtatttattt ttattctaat gatccattaa aggtatatat ttatttcttg    10560

ttatataatc cttttgttta ttacatgggc tggatacata aaggtatttt gatttaattt    10620

tttgcttaaa ttcaatcccc cctcgttcag tgtcaactgt aatggtagga aattaccata    10680

cttttgaaga agcaaaaaaa atgaaagaaa aaaaaaatcg tatttccagg ttagacgttc    10740

cgcagaatct agaatgcggt atgcggtaca ttgttcttcg aacgtaaaag ttgcgctccc    10800

tgagatattg tacatttttg cttttacaag tacaagtaca tcgtacaact atgtactact    10860

gttgatgcat ccacaacagt ttgttttgtt tttttttgtt tttttttttt ctaatgattc    10920

attaccgcta tgtataccta cttgtacttg tagtaagccg ggttattggc gttcaattaa    10980

tcatagactt atgaatctgc acggtgtgcg ctgcgagtta cttttagctt atgcatgcta    11040

cttgggtgta atattgggat ctgttcggaa atcaacggat gctcaatcga taaaaaacaa    11100

aaaaaaaagc accgactcgg tgccactttt tcaagttgat aacggactag ccttatttta    11160

acttgctatt tctagc                                                    11176


