                         SEQUENCE LISTING

<110>  AEQUUS BIOPHARMA, INC.
       BERENSON, Ronald
       CLEGG, Christopher H.
 
<120>  MELANOCORTINS AND METHODS OF USE THEREOF

<130>  49549-701.601

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-24

<400>  1

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg 
            20                  25                  30          


Pro Val Lys Val Tyr Pro 
        35              


<210>  2
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-24 with natural linker

<400>  2

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Lys Arg Ser Tyr Ser Met 
            20                  25                  30          


Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val 
        35                  40                  45              


Lys Val Tyr Pro 
    50          


<210>  3
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Gamma-MSH  ACTH1-24


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  3

Tyr Val Xaa Gly His Xaa Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg 
            20                  25                  30          


Pro Val Lys Val Tyr Pro 
        35              


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<400>  4

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
            20                  25          


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  Alpha-MSH with natural linker


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<400>  5

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Lys Arg Ser Tyr Ser Met 
            20                  25                  30          


Glu His Phe Arg Trp Gly Lys Pro Val 
        35                  40      


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Gamma-MSH  Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  6

Tyr Val Xaa Gly His Xaa Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
            20                  25          


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  NDP-Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  7

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
            20                  25          


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Gamma-MSH  NDP-Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  8

Tyr Val Xaa Gly His Xaa Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
            20                  25          


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH with linker

<400>  9

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Lys Arg 
            20                  25              


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24

<400>  10

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<400>  11

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  12

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  13
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-39 without linker

<400>  13

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Lys Arg Ser Tyr 
1               5                   10                  15      


Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg 
            20                  25                  30          


Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu Ala 
        35                  40                  45              


Phe Pro Leu Glu Phe Lys Arg 
    50                  55  


<210>  14
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-24 linker without cleavable site

<400>  14

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Ser Tyr Ser Met Glu His 
            20                  25                  30          


Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val 
        35                  40                  45              


Tyr Pro 
    50  


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-24 without linker and cleavage site

<400>  15

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly Ser Tyr Ser Met 
1               5                   10                  15      


Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val 
            20                  25                  30          


Lys Val Tyr Pro 
        35      


<210>  16
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Beta--endorphin

<400>  16

Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr 
1               5                   10                  15      


Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            20                  25                  30      


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Beta--MSH

<400>  17

Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu His Phe Arg Trp 
1               5                   10                  15      


Gly Ser Pro Pro Lys Asp 
            20          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Gamma-MSH


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  18

Tyr Val Xaa Gly His Xaa Arg Trp Asp Arg Phe Gly 
1               5                   10          


<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-39

<400>  19

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala 
            20                  25                  30          


Glu Ala Phe Pro Leu Glu Phe Lys Arg 
        35                  40      


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH

<400>  20

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe Gly 
1               5                   10          


<210>  21
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta POMC glycopolymer

<400>  21

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala 
            20                  25                  30          


Glu Ala Phe Pro Leu Glu Phe Lys Arg Glu Leu Thr Gly Gln Arg Leu 
        35                  40                  45              


Arg Glu Gly Asp Gly Pro Asp Gly Pro Ala Asp Asp Gly Ala Gly Ala 
    50                  55                  60                  


Gln Ala Asp Leu Glu His Ser Leu Leu Val Ala Ala Glu Lys Lys Asp 
65                  70                  75                  80  


Glu Gly Pro Tyr Arg Met Glu His Phe Arg Trp Gly Ser Pro Pro Lys 
                85                  90                  95      


Asp Lys Arg Tyr Gly Gly Phe Met Gly Gly Ser Gly Gly Ser Gly Gly 
            100                 105                 110         


Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr 
        115                 120                 125             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr 
                165                 170                 175     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly 
            180                 185                 190         


Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly 
        195                 200                 205             


Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr 
    210                 215                 220                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Asn Asn Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr 
            260                 265                 270         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asn Asn Thr Gly Gly Ser Gly 
        275                 280                 285             


Gly Ser 
    290 


<210>  22
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma-MSH  ACTH1-39 fusion protein

<400>  22

Glu Val Arg Gly Trp Cys Leu Glu Ser Ser Gln Cys Gln Asp Leu Thr 
1               5                   10                  15      


Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg Ala Cys Lys Pro Asp Leu 
            20                  25                  30          


Ser Ala Glu Thr Pro Met Phe Pro Gly Asn Gly Asp Glu Gln Pro Leu 
        35                  40                  45              


Thr Glu Asn Pro Arg Lys Tyr Val Met Gly His Phe Arg Trp Asp Arg 
    50                  55                  60                  


Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln 
65                  70                  75                  80  


Lys Arg Glu Asp Val Ser Ala Gly Glu Asp Cys Gly Pro Leu Pro Glu 
                85                  90                  95      


Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala Lys Pro Gly Pro Arg Glu 
            100                 105                 110         


Gly Lys Arg Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
        115                 120                 125             


Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp 
    130                 135                 140                 


Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe Lys Arg Ala Glu Lys Lys 
145                 150                 155                 160 


Asp Glu Gly Pro Tyr Arg Met Glu His Phe Arg Trp Gly Ser Pro Pro 
                165                 170                 175     


Lys Asp Gly Gly Ser Gly Gly Ser 
            180                 


<210>  23
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH  linker-linker ACTH1-24


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  23

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ser Tyr Ser Met Glu His Phe Arg Trp 
            20                  25                  30          


Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro 
        35                  40                  45          


<210>  24
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH  linker-Furin site-linker  ACTH1-24


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  24

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val Gly Gly Gly 
1               5                   10                  15      


Gly Ser Arg Arg Lys Arg Gly Gly Gly Gly Ser Ser Tyr Ser Met Glu 
            20                  25                  30          


His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys 
        35                  40                  45              


Val Tyr Pro 
    50      


<210>  25
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH  linker-MMP site-linker  ACTH1-24


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  25

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val Gly Gly Gly 
1               5                   10                  15      


Gly Ser Pro Leu Gly Leu Trp Ala Gly Gly Gly Gly Ser Ser Tyr Ser 
            20                  25                  30          


Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro 
        35                  40                  45              


Val Lys Val Tyr Pro 
    50              


<210>  26
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  linker-linker  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  26

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  45          


<210>  27
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  linker-Furin site-linker  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  27

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Arg Arg Lys 
            20                  25                  30          


Arg Gly Gly Gly Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly 
        35                  40                  45              


Lys Pro Val 
    50      


<210>  28
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  linker-MMP site-linker  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  28

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Pro Leu Gly 
            20                  25                  30          


Leu Trp Ala Gly Gly Gly Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg 
        35                  40                  45              


Trp Gly Lys Pro Val 
    50              


<210>  29
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  linker-MMP (broad) site-linker  
       NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  29

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Pro Ala Gly 
            20                  25                  30          


Leu Val Ala Gly Gly Gly Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg 
        35                  40                  45              


Trp Gly Lys Pro Val 
    50              


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH4-9

<400>  30

Met Glu His Phe Arg Trp 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  31

Xaa Glu His Xaa Arg Trp 
1               5       


<210>  32
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH  linker-MMP (broad) site-linker  
       ACTH1-24


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  32

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val Gly Gly Gly 
1               5                   10                  15      


Gly Ser Pro Ala Gly Leu Val Ala Gly Gly Gly Gly Ser Ser Tyr Ser 
            20                  25                  30          


Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro 
        35                  40                  45              


Val Lys Val Tyr Pro 
    50              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Acetylated Alpha-MSH


<220>
<221>  misc_feature
<223>  Acetylation on 5' end and NH2 on 3' end

<400>  33

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HFRWKPV-NH2


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<400>  34

His Phe Arg Trp Lys Pro Val 
1               5           


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HFRW

<400>  35

His Phe Arg Trp 
1               


<210>  36
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: KPV-NH2


<220>
<221>  misc_feature
<223>  NH2 at 3' end

<400>  36

Lys Pro Val 
1           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: KPVHFRW

<400>  37

Lys Pro Val His Phe Arg Trp 
1               5           


<210>  38
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  proconvertase  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  38

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Arg Arg Lys 
            20                  25                  30          


Arg Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  45      


<210>  39
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  natural N-terminal spacer  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  39

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Pro Leu Pro Glu Gly Gly Pro Glu 
            20                  25                  30          


Pro Arg Ser Asp Gly Ala Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser 
        35                  40                  45              


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
    50                  55                  60  


<210>  40
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  natural C-terminal spacer  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  40

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Glu Leu Thr Gly Gln Arg Leu Arg 
            20                  25                  30          


Glu Gly Asp Gly Pro Asp Gly Pro Ala Asp Asp Gly Ala Gly Ala Ser 
        35                  40                  45              


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
    50                  55                  60  


<210>  41
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  proconvertase  Alpha-MSH

<400>  41

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Arg Arg Lys 
            20                  25                  30          


Arg Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
        35                  40                  45      


<210>  42
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  natural N-terminal spacer  Alpha-MSH

<400>  42

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Pro Leu Pro Glu Gly Gly Pro Glu 
            20                  25                  30          


Pro Arg Ser Asp Gly Ala Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser 
        35                  40                  45              


Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
    50                  55                  60  


<210>  43
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  natural C-terminal spacer  Alpha-MSH

<400>  43

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Glu Leu Thr Gly Gln Arg Leu Arg 
            20                  25                  30          


Glu Gly Asp Gly Pro Asp Gly Pro Ala Asp Asp Gly Ala Gly Ala Ser 
        35                  40                  45              


Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
    50                  55                  60  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala   NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  44

Xaa Glu His Xaa Arg Trp Ala Gly Ala Xaa Glu His Xaa Arg Trp 
1               5                   10                  15  


<210>  45
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala  ACTH1-24


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<400>  45

Xaa Glu His Xaa Arg Trp Ala Gly Ala Ser Tyr Ser Met Glu His Phe 
1               5                   10                  15      


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
            20                  25                  30          


Pro 
    


<210>  46
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9   ACTH1-24


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  46

Xaa Glu His Xaa Arg Trp Ser Tyr Ser Met Glu His Phe Arg Trp Gly 
1               5                   10                  15      


Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro 
            20                  25                  30  


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  47

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  48
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-5

<400>  48

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Ala Val Lys Val Tyr Pro 
            20                  


<210>  49
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-1-2

<400>  49

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ala Ala 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  50
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-3-5

<400>  50

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Ala Ala Ala Val Lys Val Tyr Pro 
            20                  


<210>  51
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  51

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Ser Tyr Ser Xaa Glu His Xaa Arg 
            20                  25                  30          


Trp Gly Lys Pro Val 
        35          


<210>  52
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-5  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  52

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Ala Val Lys Val Tyr Pro Ser Tyr Ser Xaa Glu His Xaa Arg 
            20                  25                  30          


Trp Gly Lys Pro Val 
        35          


<210>  53
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-1-2  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  53

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ala Ala 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Ser Tyr Ser Xaa Glu His Xaa Arg 
            20                  25                  30          


Trp Gly Lys Pro Val 
        35          


<210>  54
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-3-5  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  54

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Ala Ala Ala Val Lys Val Tyr Pro Ser Tyr Ser Xaa Glu His Xaa Arg 
            20                  25                  30          


Trp Gly Lys Pro Val 
        35          


<210>  55
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  4aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  55

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Ser Ser Tyr Ser Xaa 
            20                  25                  30          


Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40      


<210>  56
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-5  4aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  56

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Ala Val Lys Val Tyr Pro Gly Gly Gly Ser Ser Tyr Ser Xaa 
            20                  25                  30          


Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40      


<210>  57
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-1-2  4aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  57

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ala Ala 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Ser Ser Tyr Ser Xaa 
            20                  25                  30          


Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40      


<210>  58
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-3-5  4aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  58

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Ala Ala Ala Val Lys Val Tyr Pro Gly Gly Gly Ser Ser Tyr Ser Xaa 
            20                  25                  30          


Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40      


<210>  59
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24   7aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  59

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  


<210>  60
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-5  7aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  60

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Ala Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  


<210>  61
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-1-2  7aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  61

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ala Ala 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  


<210>  62
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-3-5  7aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  62

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Ala Ala Ala Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  


<210>  63
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-5  10aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  63

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Ala Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  45          


<210>  64
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-1-2  10aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  64

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ala Ala 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  45          


<210>  65
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24-point-3-5  10aa  NDP-Alpha-MSH


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  65

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Ala Ala Ala Val Lys Val Tyr Pro Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
        35                  40                  45          


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9   Beta-Ala-G Ala    ACTH1-24  Beta-Ala-G 
       Ala   NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  66

Xaa Glu His Xaa Arg Trp Ala Gly Ala Ser Tyr Ser Met Glu His Phe 
1               5                   10                  15      


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
            20                  25                  30          


Pro Ala Gly Ala Xaa Glu His Xaa Arg Trp 
        35                  40          


<210>  67
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala   NDP-ACTH4-9  Beta-Ala-G 
       Ala   ACTH1-24  Beta-Ala-G Ala   NDP-ACTH4-9   Beta-Ala-G Ala   
       NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  67

Xaa Glu His Xaa Arg Trp Ala Gly Ala Xaa Glu His Xaa Arg Trp Ala 
1               5                   10                  15      


Gly Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly 
            20                  25                  30          


Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Ala Gly Ala Xaa Glu His 
        35                  40                  45              


Xaa Arg Trp Ala Gly Ala Xaa Glu His Xaa Arg Trp 
    50                  55                  60  


<210>  68
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala   ACTH1-24  Beta-Ala-G Ala
       NDP-ACTH4-9  Beta-Ala-G Ala   NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  68

Xaa Glu His Xaa Arg Trp Ala Gly Ala Ser Tyr Ser Met Glu His Phe 
1               5                   10                  15      


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
            20                  25                  30          


Pro Ala Gly Ala Xaa Glu His Xaa Arg Trp Ala Gly Ala Xaa Glu His 
        35                  40                  45              


Xaa Arg Trp 
    50      


<210>  69
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala   NDP-ACTH4-9  Beta-Ala-G 
       Ala   ACTH1-24  Beta-Ala-G Ala   NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  69

Xaa Glu His Xaa Arg Trp Ala Gly Ala Xaa Glu His Xaa Arg Trp Ala 
1               5                   10                  15      


Gly Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly 
            20                  25                  30          


Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Ala Gly Ala Xaa Glu His 
        35                  40                  45              


Xaa Arg Trp 
    50      


<210>  70
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTH1-24  Beta-Ala-G Ala   NDP-ACTH4-9


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  70

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Ala Gly Ala Xaa Glu His Xaa Arg 
            20                  25                  30          


Trp 
    


<210>  71
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-ACTH4-9  Beta-Ala-G Ala   ACTH1-24


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is DPhe (D-phenylalanine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Ala is Beta Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Ala is Beta Ala

<400>  71

Xaa Glu His Xaa Arg Trp Ala Gly Ala Ser Tyr Ser Met Glu His Phe 
1               5                   10                  15      


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
            20                  25                  30          


Pro 
    


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NDP-Alpha-MSH


<220>
<221>  misc_feature
<223>  Acetylation on 5' end

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is DPhe (D-phenylalanine)

<400>  72

Ser Tyr Ser Xaa Glu His Xaa Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  73

Arg Arg Lys Arg 
1               


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  74

Lys Lys Arg Arg 
1               


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  75

Arg Arg Asn Ser Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Lys Arg 
1               5                   10                  15      


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  76

Glu Arg Leu Lys Arg Ala Val Gly Ser 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  77

Ser Arg Ser Arg Arg Ser Ala Gly Ser 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  78

Glu Arg Ser Lys Arg Ala Val Gly Ser 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  79

Glu Arg Leu Lys Arg Ala Ala Gly Ser 
1               5                   


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  81

Pro Leu Gly Leu Trp Ala 
1               5       


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  82

Pro Gln Ala Leu Val Ala 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  83

Pro Ala Asn Leu Val Gly 
1               5       


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  84

Pro Ala Glu Leu Ile Gly 
1               5       


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  85

Pro Ala Asn Leu Val Ala 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  86

Pro Ala Gly Leu Val Gly 
1               5       


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  87

Pro Ala Gly Leu Val Ala 
1               5       


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma2-MSH

<400>  88

Tyr Val Met Gly His Phe Arg Trp Asp Arg Phe 
1               5                   10      


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  "GGGS" may repeat any number of times

<400>  89

Gly Gly Gly Ser 
1               


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  "GGGGS" may repeat any number of times

<400>  90

Gly Gly Gly Gly Ser 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  91

Glu Ala Ala Ala Lys 
1               5   


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  92

Gly Gly Gly Ser 
1               


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  93

Gly Gly Gly Gly Ser Gly Gly 
1               5           


