                         SEQUENCE LISTING

<110>  Rowan University
 
<120>  EARLY-STAGE ALZHEIMER'S DISEASE AUTOANTIBODY BIOMARKERS, TARGET 
       ANTIGENS, AND DIAGNOSTIC USES THEREOF

<130>  125107.00090

<150>  62/266,790
<151>  2015-12-15

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  919
<212>  DNA
<213>  Homo sapiens

<400>  1
cacaagaggc agcactcagg acaatctcca gcatggcctg gtctcctctc ctcctcactc       60

tcctcgctca ctgcacaggg tcctgggccc agtctgtgct gacgcagccg ccctcagtgt      120

ctggggcccc agggcagagg gtcaccatct cctgcactgg gagcagttcc aacatcgggg      180

caggttatga tgtacactgg taccagcagc ttccaggaac agcccccaaa ctcctcatct      240

atggtaacag caatcggccc tcaggggtcc ctgaccgatt ctctggctcc aagtctggca      300

cctcagcctc cctggccatc actgggctcc aggctgagga tgaggctgat tattactgcc      360

aatcctatga ctacagcctg agtgcttcgg gggtgttcgg cggagggacc aagctgaccg      420

tcctaggtca gcccaaggct gccccctcgg tcactctgtt cccgccctcc tctgaggagc      480

ttcaagccaa caaggccaca ctggtgtgtc tcataagtga cttctacccg ggagccgtga      540

cagtggcctg gaaggcagat agcagccccg tcaaggcggg agtggagacc accacaccct      600

ccaaacaaag caacaacaag tacgcggcca gcagctacct gagcctgacg cctgagcagt      660

ggaagtccca cagaagctac agctgccagg tcacgcatga agggagcacc gtggagaaga      720

cagtggcccc tacagaatgt tcataggttc taaaccctca ccccccccac gggagactag      780

agctgcagga tcccagggga ggggtctctc ctcccacccc aaggcatcaa gcccttctcc      840

ctgcactcaa taaaccctca ataaatattc tcattgtcaa tcaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaa                                                   919


<210>  2
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Tyr Ser Leu Ser Ala Ser Gly Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  3
<211>  903
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcataagag gcagcactca ggacaatctc cagcatggcc tggtctcctc tcctcctcac       60

tctcctcgct cactgcacag ggtcctgggc ccagtctgtg ctgacgcagc cgccctcagt      120

gtctggggcc ccagggcaga gggtcaccat ctcctgcact gggagcagct ccaacatcgg      180

ggcaggttat gatgtacact ggtaccagca gcttccagga acagccccca aactcctcat      240

ctatggtaac agcaatcggc cctcaggggt ccctgaccga ttctctggct ccaagtctgg      300

cacctcagcc tccctggcca tcactgggct ccaggctgag gatgaggctg attattactg      360

ccagtcctat gacagcagcc tgagtggttt tgtggtattc ggcggaggga ccaagctgac      420

cgtcctaggt cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga      480

gcttcaagcc aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt      540

gacagtggcc tggaaggcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc      600

ctccaaacaa agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca      660

gtggaagtcc cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa      720

gacagtggcc cctacagaat gttcataggt tctcaaccct caccccccac cacgggagac      780

tagagctgca ggatcccagg ggaggggtct ctcctcccac cccaaggcat caagcccttc      840

tccctgcact caataaaccc tcaataaata ttctcattgt caatcaaaaa aaaaaaaaaa      900

aaa                                                                    903


<210>  4
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Ser Leu Ser Gly Phe Val Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  5
<211>  2403
<212>  DNA
<213>  Homo sapiens

<400>  5
gtccttccca agaccacacc caggtccagt cattccctag gacttggcag agagctgtac       60

tcacagccaa gatcacagca aaatcagcaa agggaaaagg catgcagagt gaagtccaga      120

ggcaaccaga cagaagcatc cagaatcctc tcacagtggg gtcacacacc ccatgcttaa      180

ctcccccaac aatgagttgt aacaacagtc aggtgtggtg gtgtgtgcct gtagtcccag      240

ctacttggga gcctgaggca ggaggatcac ttgagtccag cagttcaaga ctgcagtgag      300

ctatgatcat accactgcac tccagcctga gtgacagagt gaaactctgt ctctaaaata      360

gggctcacct gcttgaggaa acaggaactg cctcggggca gccagccccg ccccattgac      420

gtgcagacct tgaatcgaaa cccaggctcc tgcaggcact ggcacagcta cagcgagggc      480

ctcggccatc caagggtctc ccaggtgacc ttccctccac cccaggaagc tatgacagag      540

gccgggaagc tgcccctacc gctaccccca cggctggact ggtttgtgca cacccagatg      600

ggccagctgg cccaagacgg ggtccccgag tggttccatg gtgcaatctc aagagaggat      660

gctgagaact tgctggagtc acagccactg ggatcctttc tcatcagggt cagtcacagc      720

catgtgggct acacactctc ctacaaagcc caaagcagct gctgccattt catggtgaag      780

ctcttggatg atgggacttt catgatcccc ggggagaagg tggcccacac ctcgctggac      840

gccctggtca ccttccacca gcagaagcca attgagccgc gcagggagct gctgacacag      900

ccctgcaggc agaaggatcc cgcaaacgtg gattacgagg atctcttcct ctactccaac      960

gcagtggccg aggaagctgc ctgcccggtg tctgcccctg aggaggcctc cccaaagcca     1020

gtcctgtgtc accaatcaaa ggaaaggaag ccgtcagcag agatgaacag aataaccacc     1080

aaggaagcca cttcctcctg ccccccaaaa tcccctcttg gagagacccg ccagaaactc     1140

tggaggagcc tcaaaatgct ccccgagaga ggccagaggg tccggcagca gctaaaaagc     1200

cacctcgcca ctgtgaactt gtcgtcactc ttggatgtcc ggagatccac ggtgatctca     1260

ggccctggga ccggaaaagg cagccaagat cactcagggg atcccacctc gggggacaga     1320

ggctacacgg atccctgtgt ggccacatct ctcaaaagcc cctcacagcc ccaggcacca     1380

aaagacagaa aggtccccac caggaaggcc gagaggtcgg tcagctgcat tgaggtgacc     1440

ccaggggaca ggagttggca ccaaatggta gtgagagccc tatcctccca ggagtccaag     1500

ccagagcacc agggcttggc agagcctgag aacgaccagc tcccggagga gtaccaacaa     1560

ccgccaccct ttgcccctgg gtactgctag agaacaggtc caccctggct ctgggactcg     1620

ctgccagggg ctgccacact cctgaatgcc ttaacatttc ttccatggcc ccacaccatg     1680

gcatccgggg gtcttcggga acccgggaaa tggaataaag atgtttttgg ggtctgttcc     1740

tgcactcacc catggggtga gctggttatt ttagcaacaa tcatcagagt gacgctgatg     1800

gtttggggca ccagctatac atcagcccca gtgccagacc ttctattcat tattttacgc     1860

ctcagagcaa ggccctcagg gagggtcatc ctccatgttt tgaagaagag actgaggttc     1920

agagaggata agaggcgtga ccaaggccac agagctatgg gtgtcagcac caggatttga     1980

agccaggtga atccgagccc ttttcccata tcatctgttt gttctgttgt ctaaaagcac     2040

actgcaagcc gggctcagtg gctcatgcct gtagtcccag cactctgtgg ggccgaggca     2100

ggcagatcgc ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc     2160

tatactaaaa aattcaaaaa ttacccggac gtggtggcgc atgcctgtaa tcccagctac     2220

ttgggagcct gaggcgggag aattgcttga acccgggagg cagaggttgc agtgagccga     2280

gatcgcatca ctgcagtcca gcctggatga cagagtgaga ctccatctca aaaaataaat     2340

aaataaataa aaatgaaatt aaaaaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaa                                                                   2403


<210>  6
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Ala Gly Lys Leu Pro Leu Pro Leu Pro Pro Arg Leu Asp 
1               5                   10                  15      


Trp Phe Val His Thr Gln Met Gly Gln Leu Ala Gln Asp Gly Val Pro 
            20                  25                  30          


Glu Trp Phe His Gly Ala Ile Ser Arg Glu Asp Ala Glu Asn Leu Leu 
        35                  40                  45              


Glu Ser Gln Pro Leu Gly Ser Phe Leu Ile Arg Val Ser His Ser His 
    50                  55                  60                  


Val Gly Tyr Thr Leu Ser Tyr Lys Ala Gln Ser Ser Cys Cys His Phe 
65                  70                  75                  80  


Met Val Lys Leu Leu Asp Asp Gly Thr Phe Met Ile Pro Gly Glu Lys 
                85                  90                  95      


Val Ala His Thr Ser Leu Asp Ala Leu Val Thr Phe His Gln Gln Lys 
            100                 105                 110         


Pro Ile Glu Pro Arg Arg Glu Leu Leu Thr Gln Pro Cys Arg Gln Lys 
        115                 120                 125             


Asp Pro Ala Asn Val Asp Tyr Glu Asp Leu Phe Leu Tyr Ser Asn Ala 
    130                 135                 140                 


Val Ala Glu Glu Ala Ala Cys Pro Val Ser Ala Pro Glu Glu Ala Ser 
145                 150                 155                 160 


Pro Lys Pro Val Leu Cys His Gln Ser Lys Glu Arg Lys Pro Ser Ala 
                165                 170                 175     


Glu Met Asn Arg Ile Thr Thr Lys Glu Ala Thr Ser Ser Cys Pro Pro 
            180                 185                 190         


Lys Ser Pro Leu Gly Glu Thr Arg Gln Lys Leu Trp Arg Ser Leu Lys 
        195                 200                 205             


Met Leu Pro Glu Arg Gly Gln Arg Val Arg Gln Gln Leu Lys Ser His 
    210                 215                 220                 


Leu Ala Thr Val Asn Leu Ser Ser Leu Leu Asp Val Arg Arg Ser Thr 
225                 230                 235                 240 


Val Ile Ser Gly Pro Gly Thr Gly Lys Gly Ser Gln Asp His Ser Gly 
                245                 250                 255     


Asp Pro Thr Ser Gly Asp Arg Gly Tyr Thr Asp Pro Cys Val Ala Thr 
            260                 265                 270         


Ser Leu Lys Ser Pro Ser Gln Pro Gln Ala Pro Lys Asp Arg Lys Val 
        275                 280                 285             


Pro Thr Arg Lys Ala Glu Arg Ser Val Ser Cys Ile Glu Val Thr Pro 
    290                 295                 300                 


Gly Asp Arg Ser Trp His Gln Met Val Val Arg Ala Leu Ser Ser Gln 
305                 310                 315                 320 


Glu Ser Lys Pro Glu His Gln Gly Leu Ala Glu Pro Glu Asn Asp Gln 
                325                 330                 335     


Leu Pro Glu Glu Tyr Gln Gln Pro Pro Pro Phe Ala Pro Gly Tyr Cys 
            340                 345                 350         


<210>  7
<211>  1546
<212>  DNA
<213>  Homo sapiens

<400>  7
accacctctg ctgccgcgcg cctaccggag ccgcttggcc ctagtgcttt ccagcggatt       60

tcccctcagg tgcggagccg ggtgccgggg tcccacagcc aaccactacc ggttcctctt      120

tcgtcagcca ccggcgccgg caggacccgc gaatcccgat ctccaggagc ctgtaaggag      180

gccgcccatt ggctcagccg cactgctggg caggtacttc caaagctttg aggattggct      240

gatgctctgg gcgccggggc tagttggcgg gtaggatcac gtgcgagggg caggccccgt      300

ctaggccccg cctccttgct gctgctgccg ccgccaatcc tggtccggtt gcccgagttc      360

ccggaggtct ctcgcgggac ctctctcacc gccaccgctc ctactctcgg gcttccaaat      420

ctggggcgat gtctccccag gttaaattac cctagctcct gctccagatc gcttccccgt      480

gccccgccag agcccagtag ttcaaaaatt aaatttgggg caaggggtgc gcgccagagc      540

gcagctgttt ctggagcctg cggcagcggt ggcgagccac agggcggcga ccgtgagctc      600

cgggagctgc gcaaaccacc tggagaccat gtctggggat gcgaccagga ccctggggaa      660

aggaagccag cccccagggc cagtcccgga ggggctgatc cgcatctaca gcatgaggtt      720

ctgcccctat tctcacagga cccgcctcgt cctcaaggcc aaagacatca gacatgaagt      780

ggtcaacatt aacctgagaa acaagcctga atggtactat acaaagcacc cttttggcca      840

cattcctgtc ctggagacca gccaatgtca actgatctat gaatctgtta ttgcttgtga      900

gtacctggat gatgcttatc caggaaggaa gctgtttcca tatgaccctt atgaacgagc      960

tcgccaaaag atgttattgg agctattttg taaggtccca catttgacca aggagtgcct     1020

ggtagcgttg agatgtggga gagaatgcac taatctgaag gcagccctgc gtcaggaatt     1080

cagcaacctg gaagagattc ttgagtatca gaacaccacc ttctttggtg gaacctgtat     1140

atccatgatt gattacctcc tctggccctg gtttgagcgg ctggatgtgt atgggatact     1200

ggactgtgtg agccacacgc cagccctgcg gctctggata tcagccatga agtgggaccc     1260

cacagtctgt gctcttctca tggataagag cattttccag ggcttcttga atctctattt     1320

tcagaacaac cctaatgcct ttgactttgg gctgtgctga gtctcactgt ccaccccttc     1380

gctgtccaga attccccagc ttgttgggag tctacgtcac ggcttgtctt gggaaccaat     1440

ccgtctctct ttcttttctt tgaagttccc aataaaatga aaacaggaaa tgtaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    1546


<210>  8
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Gly Asp Ala Thr Arg Thr Leu Gly Lys Gly Ser Gln Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Leu Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Tyr Ser His Arg Thr Arg Leu Val Leu Lys Ala Lys Asp Ile Arg 
        35                  40                  45              


His Glu Val Val Asn Ile Asn Leu Arg Asn Lys Pro Glu Trp Tyr Tyr 
    50                  55                  60                  


Thr Lys His Pro Phe Gly His Ile Pro Val Leu Glu Thr Ser Gln Cys 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Val Ile Ala Cys Glu Tyr Leu Asp Asp Ala 
                85                  90                  95      


Tyr Pro Gly Arg Lys Leu Phe Pro Tyr Asp Pro Tyr Glu Arg Ala Arg 
            100                 105                 110         


Gln Lys Met Leu Leu Glu Leu Phe Cys Lys Val Pro His Leu Thr Lys 
        115                 120                 125             


Glu Cys Leu Val Ala Leu Arg Cys Gly Arg Glu Cys Thr Asn Leu Lys 
    130                 135                 140                 


Ala Ala Leu Arg Gln Glu Phe Ser Asn Leu Glu Glu Ile Leu Glu Tyr 
145                 150                 155                 160 


Gln Asn Thr Thr Phe Phe Gly Gly Thr Cys Ile Ser Met Ile Asp Tyr 
                165                 170                 175     


Leu Leu Trp Pro Trp Phe Glu Arg Leu Asp Val Tyr Gly Ile Leu Asp 
            180                 185                 190         


Cys Val Ser His Thr Pro Ala Leu Arg Leu Trp Ile Ser Ala Met Lys 
        195                 200                 205             


Trp Asp Pro Thr Val Cys Ala Leu Leu Met Asp Lys Ser Ile Phe Gln 
    210                 215                 220                 


Gly Phe Leu Asn Leu Tyr Phe Gln Asn Asn Pro Asn Ala Phe Asp Phe 
225                 230                 235                 240 


Gly Leu Cys 
            


<210>  9
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  9
ggggggggtc acaagaggca gcgctctcgg gacgtctcca ccatggcctg ggctctgctg       60

ctcctcactc tcctcactca ggacacaggg tcctgggccc agtctgccct gactcagcct      120

gcctccgtgt ctgggtctcc tggacagtcg atcaccatct cctgcactgg aaccagcact      180

gatgttggga gtcatagcct tgtctcctgg taccaacagc acccaggcaa agcccccaaa      240

tttcttattt tcgagggcag taagcggccc tcaggggttt cgaatcgctt ctctggctcc      300

aagtctggca acacggcctc cctgacaatc tctgggctcc aggctgagga cgaggctgat      360

tattactgct gttcatatgt tggtagtggc actgtggttt tcggcggagg gacgaagctg      420

accgtcctag gtcagcccaa ggctgccccc tcggtcactc tgttcccgcc ctcctctgag      480

gagcttcaag ccaacaaggc cacactggtg tgtctcataa gtgacttcta cccgggagcc      540

gtgacagtgg cctggaaggc agatagcagc cccgtcaagg cgggagtgga gaccaccaca      600

ccctccaaac aaagcaacaa caagtacgcg gccagcagct atctgagcct gacgcctgag      660

cagtggaagt cccacagaag ctacagctgc caggtcacgc atgaagggag caccgtggag      720

aagacagtgg cccctacaga atgttcatag gttctcaacc ctcaccccca ccacgggaga      780

ctagagctgc aggatcccag gggaggggtc tctcctccca ccccaaggca tcaagccctt      840

ctccctgcac tcaataaacc ctcaataaat attctcattg tcaagcaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaa                                                       915


<210>  10
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Asp Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
            20                  25                  30          


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Val 
        35                  40                  45              


Gly Ser His Ser Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Phe Leu Ile Phe Glu Gly Ser Lys Arg Pro Ser Gly Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr 
            100                 105                 110         


Val Gly Ser Gly Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


