                         SEQUENCE LISTING

<110>  De Waal Malefyt, Rene
       Fayadat-Dilman, Laurence
       Liang, Linda
 
<120>  ANTI-LAG3 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS

<130>  24270

<150>  62/268,070
<151>  2015-12-16

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Q or E

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  G, L, S, T, Y, V or A

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  M or L

<400>  1

Xaa Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Asn Ser Gly Xaa Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Tyr Asp Ser Ser Asp Gln Leu Asn Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ser Ile Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gln Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Glu Phe Asp Ile Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Pro Pro Glu Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  M, G, L, S, T, Y, V or A

<400>  6

Trp Ile Asn Ala Asn Ser Gly Xaa Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Tyr Asp Ser Ser Asp Gln Leu Asn Val 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Gln Ala Ser Ile Trp Pro Leu Thr 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Tyr Thr Phe Gln Gly Tyr Tyr Met His 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Arg Gly Glu Phe Asp Ile Ala Phe Asp Ile 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Val Pro Pro Glu Pro Pro Tyr Thr 
1               5                   10  


<210>  17
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  17
atggaatgga gctgggtgtt tctgttcttc ctgtccgtga caaccggcgt gcactcccag       60

gtgcagctgg tgcagtccgg cgctgaggtc aagaaacctg gcgccagcgt caaagtgagc      120

tgtaaggcct ccggctacac ctttaccgga tactacatgc actgggtcag gcaggcccct      180

ggacagggac tggaatggat gggctggatc aacgctaaca gcggaatgac caactacgcc      240

cagaagttcc agggccgggt gacaatgacc cgggacacct ccatcagcac cgcctacatg      300

gagctgtccc ggctgaggtc cgatgacacc gctgtgtact actgcgcccg ggacatctat      360

gactcctccg accagctgaa cgtgtggggc cagggcacaa tggtgacagt gagctccgct      420

tccaccaagg gccccagcgt gtttcccctg gctccctgca gcaggagcac atccgagtcc      480

accgctgccc tgggctgtct ggtgaaggac tactttcctg agcctgtgac cgtgtcctgg      540

aatagcggcg ccctgacaag cggagtgcac acattccccg ctgtgctcca atcctccgga      600

ctgtacagcc tgagctccgt cgtgacagtg cccagcagca gcctgggcac caagacctac      660

acctgcaacg tggaccacaa gccttccaac accaaggtgg acaagagggt ggagagcaag      720

tacggccccc cttgtcctcc ttgtcctgcc cctgagttcc tcggaggacc cagcgtgttc      780

ctgtttcctc ctaaacccaa ggacaccctg atgatctccc ggacacccga agtgacatgt      840

gtggtggtgg acgtgtccca ggaagacccc gaggtgcagt tcaactggta cgtggatggc      900

gtggaagtgc ataacgctaa gaccaagccc cgggaagagc agttcaacag cacctacagg      960

gtggtgtccg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     1020

aaggtcagca acaagggcct gccctcctcc atcgagaaga ccatcagcaa ggccaaggga     1080

cagcctcggg agcctcaggt gtacaccctg cccccctccc aggaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtcgagtgg     1200

gagtccaacg gccagcctga gaataactac aagaccaccc cccctgtcct ggacagcgac     1260

ggttctttct tcctgtacag caggctgaca gtggacaagt ccaggtggca ggagggcaac     1320

gtgttctcct gctccgtgat gcacgaagcc ctgcacaatc actataccca gaagtccctc     1380

agcctgtccc tcggcaaatg a                                               1401


<210>  18
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  18
atgtccgtgc ccacccaggt gctgggactg ctgctgctgt ggctgaccga cgcccggtgt       60

gagatcgtgc tgacccagtc ccccgctacc ctgagcctgt cccctggaga gagggctacc      120

ctgtcctgta gggcctccca gtccgtgagc tcctacctgg cctggtacca gcagaaaccc      180

ggccaggctc ctaggctgct gatctacgac gcctccaata gggccaccgg cattcccgct      240

aggttctccg gaagcggctc cggcaccgac ttcaccctga ccatctccag cctggagccc      300

gaggacttcg ctgtgtacta ctgccagcag gccagcatct ggcccctgac cttcggaggc      360

ggcaccaagg tggagatcaa gaggaccgtg gccgcccctt ccgtgttcat cttccccccc      420

tccgatgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caactcccag      540

gagtccgtga cagagcagga cagcaaggac tccacctaca gcctgagctc caccctgacc      600

ctgagcaagg ccgactacga aaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      660

ctgtcctccc ctgtgaccaa gtcctttaac aggggcgagt gctga                      705


<210>  19
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  19
atggagtgga gctgggtgtt cctgtttttc ctgagcgtca ccacaggcgt gcactcccag       60

gtccagctgg tgcagtccgg agctgaggtg aagaagcctg gagcctccgt gaaggtgtcc      120

tgcaaggcct ccggctacac cttccagggc tattacatgc actgggtgag gcaggctcct      180

ggacagggac tggagtggat gggccagatt aatccccaca gcggaggcac caactacgcc      240

cagaagttcc agggccgggt gacaatgaca cgggacacct ccatcagcac agcttacatg      300

gagctgtcca ggctcaggtc cgacgacacc gccgtgtact actgcgctcg ggatcgggga      360

gagtttgaca tcgccttcga catctggggc cagggcacaa tggtgacagt gagctccgcc      420

tccaccaagg gcccttccgt gtttcccctc gccccctgta gcaggtccac atccgagtcc      480

acagctgccc tgggctgtct ggtgaaggat tacttccctg agcctgtgac agtgagctgg      540

aacagcggcg ctctgacctc cggcgtgcat acctttcccg ccgtgctgca gtccagcgga      600

ctgtacagcc tgagctccgt ggtgacagtc ccctcctcct ccctgggcac caaaacctac      660

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggaatccaag      720

tacggccctc cttgtcctcc ttgccccgct cccgagtttc tgggcggacc ttccgtgttc      780

ctgttccctc ccaagcccaa ggacacactc atgattagca ggacccccga ggtcacatgt      840

gtggtggtgg acgtgagcca ggaggacccc gaggtccagt tcaactggta cgtggatggc      900

gtggaggtgc acaacgctaa aacaaagccc cgggaagaac agttcaacag cacctatcgg      960

gtggtgtccg tgctgaccgt gctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaagtcagca acaagggcct gccttccagc atcgagaaga ccatcagcaa ggctaagggc     1080

cagcccaggg agcctcaggt ctacaccctc cccccttccc aggaggagat gacaaagaac     1140

caggtgtccc tcacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggaatgg     1200

gagtccaacg gccagcccga gaataactac aagaccacac ctcctgtgct ggattccgat     1260

ggcagcttct ttctgtactc caggctgacc gtggataagt cccggtggca ggagggcaac     1320

gtctttagct gcagcgtgat gcatgaggct ctgcacaatc actacaccca gaaaagcctc     1380

agcctgtccc tgggcaaatg a                                               1401


<210>  20
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  20
atgtccgtgc ccacccaggt gctgggactg ctcctgctgt ggctcacaga cgccaggtgc       60

gacatccaga tgacccagtc cccctcctcc ctgtccgctt ccgtgggcga cagggtgacc      120

attacctgcc aggcctccca ggacatcacc aactatctga actggtacca gcagaagccc      180

ggcaaggccc ccaaactgct gatctacgac gcctccaacc tggagaccgg cgtgccttcc      240

aggttctccg gaagcggcag cggcaccgac ttcaccttca ccatctccag cctgcagccc      300

gaggacatcg ccacctacta ctgccagcag gtgcctcctg agccccccta caccttcgga      360

ggaggcacca aggtggagat caagcggaca gtggctgctc cctccgtctt catcttcccc      420

ccctccgacg agcagctgaa gagcggaaca gcctccgtgg tgtgcctcct gaacaacttc      480

tacccccggg aggccaaagt gcagtggaag gtggacaatg ccctgcagag cggcaactcc      540

caggagtccg tcaccgagca ggacagcaag gattccacct acagcctgtc ctccaccctg      600

accctgtcca aggccgatta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcct cccccgtgac caagtccttc aaccggggcg agtgctga                   708


<210>  21
<211>  447
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Q or E

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  M, G, L, S, T, Y, V or A

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  M or L

<400>  21

Xaa Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Asn Ser Gly Xaa Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Tyr Asp Ser Ser Asp Gln Leu Asn Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  22
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ser Ile Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  23
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gln Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Glu Phe Asp Ile Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  24
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Pro Pro Glu Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IL10 CDR

<400>  25

Lys Thr Ser Gln Asn Ile Phe Glu Asn Leu Ala 
1               5                   10      


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL10 CDR

<400>  26

Asn Ala Ser Pro Leu Gln Ala 
1               5           


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL10 CDR

<400>  27

His Gln Tyr Tyr Ser Gly Tyr Thr 
1               5               


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL10 CDR

<400>  28

Gly Phe Thr Phe Ser Asp Tyr His Met Ala 
1               5                   10  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL10 CDR

<400>  29

Ser Ile Thr Leu Asp Ala Thr Tyr Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL10 CDR

<400>  30

His Arg Gly Phe Ser Val Trp Leu Asp Tyr 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  31

Gly Tyr Ile Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  32

Thr Phe Ile Pro Leu Leu Asp Thr Ser Asp Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  33

Met Gly Val Thr His Ser Tyr Val Met Asp Ala 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  34

Arg Ala Ser Gln Pro Ile Ser Ile Ser Val His 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  35

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TSLP CDR

<400>  36

Gln Gln Thr Phe Ser Leu Pro Tyr Thr 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  37

Gly Phe Ile Ile Lys Ala Thr Tyr Met His 
1               5                   10  


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  38

Arg Ile Asp Pro Ala Asn Gly Glu Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Val 
    


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  39

Tyr Ala Trp Tyr Phe Asp Val 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  40

Arg Ala Ser Glu Asn Ile Tyr Ser Phe Leu Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  41

His Ala Lys Thr Leu Ala Glu 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD27 CDR

<400>  42

Gln His Tyr Tyr Gly Ser Pro Leu Thr 
1               5                   


<210>  43
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized mouse immunoglobulin

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  44
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized mouse immunoglobulin

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  45
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin chain

<400>  45

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  46
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin chain

<400>  46

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  47
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  47
atggagtgga gctgggtctt cctgttcttt ctgtccgtca caaccggcgt gcactccgag       60

gtccagctgg tgcagtccgg cgctgaggtg aagaaacccg gcgcttccgt gaaagtgagc      120

tgcaaagcct ccggatacac cttcaccggc tactacatgc actgggtgag gcaggcccct      180

ggacagggac tggagtggat gggctggatc aacgccaaca gcggaggcac caactacgcc      240

cagaagttcc agggcagagt caccatgaca agggatacct ccatcagcac cgcctacatg      300

gagctgagca ggctgagaag cgacgataca gccgtctact actgcgccag ggatatctac      360

gactccagcg accagctgaa tgtgtggggc cagggcacac tggtgaccgt gagcagcgcc      420

tccaccaagg gccctagcgt gttccctctg gccccttgct ccagatccac atccgaatcc      480

acagccgccc tgggctgcct ggtgaaggac tatttccccg agcccgtgac cgtgtcctgg      540

aactccggag ccctgaccag cggagtgcat accttccccg ccgtgctgca gtcctccgga      600

ctgtactccc tgagcagcgt ggtcaccgtg cccagcagca gcctgggcac caagacctat      660

acatgtaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggagagcaag      720

tacggacccc cttgcccccc ctgtcccgcc cccgagttcc tgggaggccc ctccgtgttt      780

ctgttccccc ctaaacccaa ggacaccctg atgatctcca ggacacccga agtgacctgt      840

gtggtggtgg acgtgtccca ggaagatcct gaggtgcagt tcaattggta cgtcgacggc      900

gtggaggtgc acaatgccaa gaccaagcct agggaggagc agttcaactc cacctatagg      960

gtggtgagcg tgctgacagt gctgcaccaa gattggctga acggaaagga atacaagtgc     1020

aaggtgtcca acaagggcct gcctagcagc atcgagaaaa ccatctccaa agctaagggc     1080

cagcccagag aacctcaagt gtacaccctg cccccctccc aggaagagat gaccaagaac     1140

caggtgagcc tcacctgtct ggtgaaggga ttctacccca gcgacattgc cgtggagtgg     1200

gaatccaatg gccagcctga gaacaattac aagaccacac cccccgtgct ggacagcgat     1260

ggcagcttct ttctgtactc caggctgacc gtggacaaga gcaggtggca ggagggcaat     1320

gtgttctcct gcagcgtgat gcatgaggcc ctccacaatc actacaccca gaagtccctg     1380

tccctcagcc tcggaaaatg a                                               1401


