                         SEQUENCE LISTING

<110>  INSERM
       Universit de Strasbourg
       Universitt Ulm
 
<120>  Method of treatment of amyotrophic lateral sclerosis

<130>  BET16P3208

<150>  EP15/307025.5
<151>  2015-12-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Phe Asp Met Leu Arg Cys Met Leu Gly Arg Val Tyr Arg Pro Cys 
1               5                   10                  15      


Trp Gln Val 
            


<210>  2
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  2
gattttgaca tgctcagatg tatgctcgga agagtctacc gaccctgttg gcaagtc          57


<210>  3
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Val Gly Ala Met Lys Lys Gly Val Gly Arg Ala Val Gly Leu 
1               5                   10                  15      


Gly Gly Gly Ser Gly Cys Gln Ala Thr Glu Glu Asp Pro Leu Pro Asn 
            20                  25                  30          


Cys Gly Ala Cys Ala Pro Gly Gln Gly Gly Arg Arg Trp Arg Leu Pro 
        35                  40                  45              


Gln Pro Ala Trp Val Glu Gly Ser Ser Ala Arg Leu Trp Glu Gln Ala 
    50                  55                  60                  


Thr Gly Thr Gly Trp Met Asp Leu Glu Ala Ser Leu Leu Pro Thr Gly 
65                  70                  75                  80  


Pro Asn Ala Ser Asn Thr Ser Asp Gly Pro Asp Asn Leu Thr Ser Ala 
                85                  90                  95      


Gly Ser Pro Pro Arg Thr Gly Ser Ile Ser Tyr Ile Asn Ile Ile Met 
            100                 105                 110         


Pro Ser Val Phe Gly Thr Ile Cys Leu Leu Gly Ile Ile Gly Asn Ser 
        115                 120                 125             


Thr Val Ile Phe Ala Val Val Lys Lys Ser Lys Leu His Trp Cys Asn 
    130                 135                 140                 


Asn Val Pro Asp Ile Phe Ile Ile Asn Leu Ser Val Val Asp Leu Leu 
145                 150                 155                 160 


Phe Leu Leu Gly Met Pro Phe Met Ile His Gln Leu Met Gly Asn Gly 
                165                 170                 175     


Val Trp His Phe Gly Glu Thr Met Cys Thr Leu Ile Thr Ala Met Asp 
            180                 185                 190         


Ala Asn Ser Gln Phe Thr Ser Thr Tyr Ile Leu Thr Ala Met Ala Ile 
        195                 200                 205             


Asp Arg Tyr Leu Ala Thr Val His Pro Ile Ser Ser Thr Lys Phe Arg 
    210                 215                 220                 


Lys Pro Ser Val Ala Thr Leu Val Ile Cys Leu Leu Trp Ala Leu Ser 
225                 230                 235                 240 


Phe Ile Ser Ile Thr Pro Val Trp Leu Tyr Ala Arg Leu Ile Pro Phe 
                245                 250                 255     


Pro Gly Gly Ala Val Gly Cys Gly Ile Arg Leu Pro Asn Pro Asp Thr 
            260                 265                 270         


Asp Leu Tyr Trp Phe Thr Leu Tyr Gln Phe Phe Leu Ala Phe Ala Leu 
        275                 280                 285             


Pro Phe Val Val Ile Thr Ala Ala Tyr Val Arg Ile Leu Gln Arg Met 
    290                 295                 300                 


Thr Ser Ser Val Ala Pro Ala Ser Gln Arg Ser Ile Arg Leu Arg Thr 
305                 310                 315                 320 


Lys Arg Val Thr Arg Thr Ala Ile Ala Ile Cys Leu Val Phe Phe Val 
                325                 330                 335     


Cys Trp Ala Pro Tyr Tyr Val Leu Gln Leu Thr Gln Leu Ser Ile Ser 
            340                 345                 350         


Arg Pro Thr Leu Thr Phe Val Tyr Leu Tyr Asn Ala Ala Ile Ser Leu 
        355                 360                 365             


Gly Tyr Ala Asn Ser Cys Leu Asn Pro Phe Val Tyr Ile Val Leu Cys 
    370                 375                 380                 


Glu Thr Phe Arg Lys Arg Leu Val Leu Ser Val Lys Pro Ala Ala Gln 
385                 390                 395                 400 


Gly Gln Leu Arg Ala Val Ser Asn Ala Gln Thr Ala Asp Glu Glu Arg 
                405                 410                 415     


Thr Glu Ser Lys Gly Thr 
            420         


<210>  4
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Pro Phe His Ala Ser Cys Trp Asn Thr Ser Ala Glu Leu Leu 
1               5                   10                  15      


Asn Lys Ser Trp Asn Lys Glu Phe Ala Tyr Gln Thr Ala Ser Val Val 
            20                  25                  30          


Asp Thr Val Ile Leu Pro Ser Met Ile Gly Ile Ile Cys Ser Thr Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Ile Val Phe Thr Ile Ile Arg Ser Arg Lys 
    50                  55                  60                  


Lys Thr Val Pro Asp Ile Tyr Ile Cys Asn Leu Ala Val Ala Asp Leu 
65                  70                  75                  80  


Val His Ile Val Gly Met Pro Phe Leu Ile His Gln Trp Ala Arg Gly 
                85                  90                  95      


Gly Glu Trp Val Phe Gly Gly Pro Leu Cys Thr Ile Ile Thr Ser Leu 
            100                 105                 110         


Asp Thr Cys Asn Gln Phe Ala Cys Ser Ala Ile Met Thr Val Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Leu Val Gln Pro Phe Arg Leu Thr Arg Trp 
    130                 135                 140                 


Arg Thr Arg Tyr Lys Thr Ile Arg Ile Asn Leu Gly Leu Trp Ala Ala 
145                 150                 155                 160 


Ser Phe Ile Leu Ala Leu Pro Val Trp Val Tyr Ser Lys Val Ile Lys 
                165                 170                 175     


Phe Lys Asp Gly Val Glu Ser Cys Ala Phe Asp Leu Thr Ser Pro Asp 
            180                 185                 190         


Asp Val Leu Trp Tyr Thr Leu Tyr Leu Thr Ile Thr Thr Phe Phe Phe 
        195                 200                 205             


Pro Leu Pro Leu Ile Leu Val Cys Tyr Ile Leu Ile Leu Cys Tyr Thr 
    210                 215                 220                 


Trp Glu Met Tyr Gln Gln Asn Lys Asp Ala Arg Cys Cys Asn Pro Ser 
225                 230                 235                 240 


Val Pro Lys Gln Arg Val Met Lys Leu Thr Lys Met Val Leu Val Leu 
                245                 250                 255     


Val Val Val Phe Ile Leu Ser Ala Ala Pro Tyr His Val Ile Gln Leu 
            260                 265                 270         


Val Asn Leu Gln Met Glu Gln Pro Thr Leu Ala Phe Tyr Val Gly Tyr 
        275                 280                 285             


Tyr Leu Ser Ile Cys Leu Ser Tyr Ala Ser Ser Ser Ile Asn Pro Phe 
    290                 295                 300                 


Leu Tyr Ile Leu Leu Ser Gly Asn Phe Gln Lys Arg Leu Pro Gln Ile 
305                 310                 315                 320 


Gln Arg Arg Ala Thr Glu Lys Glu Ile Asn Asn Met Gly Asn Thr Leu 
                325                 330                 335     


Lys Ser His Phe 
            340 


<210>  5
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Lys Met Asn Leu Ser Ser Tyr Ile Leu Ile Leu Thr Phe Ser 
1               5                   10                  15      


Leu Phe Ser Gln Gly Ile Leu Leu Ser Ala Ser Lys Ser Ile Arg Asn 
            20                  25                  30          


Leu Asp Asp Asp Met Val Phe Asn Thr Phe Arg Leu Gly Lys Gly Phe 
        35                  40                  45              


Gln Lys Glu Asp Thr Ala Glu Lys Ser Val Ile Ala Pro Ser Leu Glu 
    50                  55                  60                  


Gln Tyr Lys Asn Asp Glu Ser Ser Phe Met Asn Glu Glu Glu Asn Lys 
65                  70                  75                  80  


Val Ser Lys Asn Thr Gly Ser Lys His Asn Phe Leu Asn His Gly Leu 
                85                  90                  95      


Pro Leu Asn Leu Ala Ile Lys Gly Tyr Gln Ala Leu Lys Gly Ser Val 
            100                 105                 110         


Asp Phe Pro Ala Glu Asn Gly Val Gln Asn Thr Glu Ser Thr Gln Glu 
        115                 120                 125             


Lys Arg Glu Ile Gly Asp Glu Glu Asn Ser Ala Lys Phe Pro Ile Gly 
    130                 135                 140                 


Arg Arg Asp Phe Asp Met Leu Arg Cys Met Leu Gly Arg Val Tyr Arg 
145                 150                 155                 160 


Pro Cys Trp Gln Val 
                165 


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Cys Met Leu Gly Arg Val Tyr Arg Pro Cys 
1               5                   10      


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Cys Met Leu Gly Arg Val Tyr Arg Pro Cys Trp 
1               5                   10          


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Phe Asp Met Leu Arg Cys Met Leu Gly Arg Val Phe Arg Pro Cys 
1               5                   10                  15      


Trp Gln Tyr 
            


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9
tctgataaat gcacgcatcc                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
gccatgcatg tctaagtacg c                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
caggctctgt tcccagagtt                                                   20


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
tctagcacct ccgccaaa                                                     18


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
tctgacatgg agctgagaca g                                                 21


<210>  14
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gaagcagccc agctcgt                                                      17


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gcctttggag cctcctctac                                                   20


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gcggcatcca ggtaatttt                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
cgagaagaag tacggccaag                                                   20


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
ctggcccctt tcctcact                                                     18


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gaggcatcct gagagaagtc c                                                 21


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
tgttaggggc gctctcttc                                                    19


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
agaagagagg ttggaccctg a                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gaggccatgc ttgtcgctaa                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
gcagaaagat ccgttgtcgc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
cggatccttt cagagcgagg                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
ccgctctgcg acactacat                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
tgtctcaggg ctggatctct                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
agccctggag gcagatctat                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
ccaagacgga ggacttgctt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
cttcaggcca acggtaacca                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
ggtgctaaag cggtggtagt                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
gctggtgtgt ctctgatctt g                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
gagtccaacc tctttgctcc a                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
aaaataccac ccaccggcaa                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
ccaggtagcg gacgaagttt                                                   20


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
agtgccagga cctcacca                                                     18


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
cagcgagagg tcgagtttg                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
gctgggagac atagcacca                                                    19


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
ttactcccct gcatggtctc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
gggcatcatt ctctgtctgg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
gggcatcatt ctctgtctgg                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
ccaatgactc ctatgacccc ta                                                22


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
cagccaagat tcacggtaga t                                                 21


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
tgcagagtct ccaccttgc                                                    19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
ggggatacca gttagcacga                                                   20


