                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  Liver targeting of cyclic preS-derived peptides of HBV

<130>  U30633WO

<150>  EP 15 200 568.2
<151>  2015-12-16

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Essential domain or pharmacophore, amino acid sequence P, with  
       Xaa = F or L


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Asn Pro Leu Gly Phe Xaa Pro 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Hepatitis B virus

<400>  2

Asn Pro Leu Gly Phe Phe Pro 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Essential domain or pharmacophore, amino acid sequence P with Xaa
       = L

<400>  3

Asn Pro Leu Gly Phe Leu Pro 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-preS9-15-Cys

<400>  4

Cys Asn Pro Leu Gly Phe Phe Pro Cys 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS9-15-Cys-D-Tyr

<400>  5

Cys Asn Pro Leu Gly Phe Phe Pro Cys Tyr 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Hepatitis B virus

<400>  6

Asn Pro Leu Gly Phe Phe Pro Asp 
1               5               


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS9-16-Cys

<400>  7

Cys Asn Pro Leu Gly Phe Phe Pro Asp Cys 
1               5                   10  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS9-16-Cys-D-Tyr

<400>  8

Cys Asn Pro Leu Gly Phe Phe Pro Asp Cys Tyr 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  9

Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS8-16-Cys

<400>  10

Cys Pro Asn Pro Leu Gly Phe Phe Pro Asp Cys 
1               5                   10      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS8-16-Cys-D-Tyr

<400>  11

Cys Pro Asn Pro Leu Gly Phe Phe Pro Asp Cys Tyr 
1               5                   10          


<210>  12
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  12

Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS9-17-Cys

<400>  13

Cys Asn Pro Leu Gly Phe Phe Pro Asp His Cys 
1               5                   10      


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS9-17-Cys-D-Tyr

<400>  14

Cys Asn Pro Leu Gly Phe Phe Pro Asp His Cys Tyr 
1               5                   10          


<210>  15
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  15

Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10  


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS8-17-Cys

<400>  16

Cys Pro Asn Pro Leu Gly Phe Phe Pro Asp His Cys 
1               5                   10          


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS8-17-Cys-D-Tyr

<400>  17

Cys Pro Asn Pro Leu Gly Phe Phe Pro Asp His Cys Tyr 
1               5                   10              


<210>  18
<211>  20
<212>  PRT
<213>  Hepatitis B virus

<400>  18

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro 
            20  


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS2-21-Cys

<400>  19

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Cys 
            20          


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS2-21-Cys-D-Tyr

<400>  20

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Cys Tyr 
            20              


<210>  21
<211>  47
<212>  PRT
<213>  Hepatitis B virus

<400>  21

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly 
        35                  40                  45          


<210>  22
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS2-48-Cys

<400>  22

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly 
        35                  40                  45              


Cys 
    


<210>  23
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-HBVpreS2-48-Cys-D-Tyr

<400>  23

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly 
        35                  40                  45              


Cys Tyr 
    50  


<210>  24
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid residues of Myrcludex B

<400>  24

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  25
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-Myrcludex B-Cys

<400>  25

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45              


Cys 
    


<210>  26
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys- Myrcludex B-Cys-D-Tyr

<400>  26

Cys Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45              


Cys Tyr 
    50  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS9-16 with Xaa = L

<400>  27

Asn Pro Leu Gly Phe Leu Pro Asp 
1               5               


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS8-16 with Xaa = L

<400>  28

Pro Asn Pro Leu Gly Phe Leu Pro Asp 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS9-17 with Xaa = L

<400>  29

Asn Pro Leu Gly Phe Leu Pro Asp His 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS8-17 with Xaa = L

<400>  30

Pro Asn Pro Leu Gly Phe Leu Pro Asp His 
1               5                   10  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS2-21 with Xaa = L

<400>  31

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Leu Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro 
            20  


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBVpreS2-48 with Xaa = L

<400>  32

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Leu Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly 
        35                  40                  45          


<210>  33
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid residues of Myrcludex B with Xaa = L

<400>  33

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Leu Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence P' with first Xaa = F or L or a natural or 
       artificial amino acid with comparable physicochemical side chain 
       properties and second Xaa = an amino acid with an acidic side 
       chain, preferably D or E


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Asn Pro Leu Gly Phe Xaa Pro Xaa 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linear amino acid sequence of cyclo-intra[NCLGFFCD]y, wherein Y =
       D-Tyr

<400>  35

Asn Cys Leu Gly Phe Phe Cys Asp Tyr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of cyclo[NPLGFFPDK] which is preS9-16-Lys

<400>  36

Asn Pro Leu Gly Phe Phe Pro Asp Lys 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of cyclo[CNPLGFFPDCK], which is 
       Cys-preS9-16-Cys-Lys

<400>  37

Cys Asn Pro Leu Gly Phe Phe Pro Asp Cys Lys 
1               5                   10      


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of cyclo[KNPLGFFPDy], which is 
       Lys-preS9-16-(D-Tyr)

<400>  38

Lys Asn Pro Leu Gly Phe Phe Pro Asp Tyr 
1               5                   10  


<210>  39
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  39

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile 
        35                  40                  45              


Lys Asp His Trp Pro Gln Ala Asn Gln Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Val Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Ala Thr Val Pro Ala Met Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Ser His Pro Gln Ala 
        115                 


<210>  40
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  40

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Lys Ala Asn Ser Glu Asn Pro Asp Trp Asp Leu Asn Pro His 
        35                  40                  45              


Lys Asp Asn Trp Pro Asp Ala His Lys Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Ser Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  41
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  41

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Lys Ala Asn Ser Glu Asn Pro Asp Trp Asp Leu Asn Pro His 
        35                  40                  45              


Lys Asp Asn Trp Pro Asp Ala His Lys Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Ser Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  42
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  42

Met Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Glu 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Lys Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Lys Lys Asp Tyr Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45              


Ala Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Leu Pro Ala Asn 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro 
                85                  90                  95      


Leu Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  43
<211>  107
<212>  PRT
<213>  Hepatitis B virus

<400>  43

Met Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        35                  40                  45              


Ala Gly Ala Phe Gly Leu Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Phe Gln Thr Leu Pro Ala Asn Pro 
65                  70                  75                  80  


Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu 
                85                  90                  95      


Ser Pro Pro Leu Arg Thr Thr His Pro Gln Ala 
            100                 105         


<210>  44
<211>  118
<212>  PRT
<213>  Hepatitis B virus

<400>  44

Met Gly Leu Ser Trp Thr Val Pro Leu Glu Trp Gly Lys Asn Ile Ser 
1               5                   10                  15      


Thr Thr Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Arg Ala Asn Thr Arg Asn Pro Asp Trp Asp His Asn Pro Asn Lys 
        35                  40                  45              


Asp His Trp Thr Glu Ala Asn Lys Val Gly Val Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala 
65                  70                  75                  80  


Gln Gly Met Leu Lys Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Thr Pro Pro Leu Arg 
            100                 105                 110         


Asp Thr His Pro Gln Ala 
        115             


<210>  45
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  45

Met Gly Ala Pro Leu Ser Thr Thr Arg Arg Gly Met Gly Gln Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Leu Phe Arg Ala Asn Ser Ser Ser Pro Asp Trp Asp Phe Asn Thr Asn 
        35                  40                  45              


Lys Asp Ser Trp Pro Met Ala Asn Lys Val Gly Val Gly Gly Tyr Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Val Leu Thr Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Arg Ser Gly Arg Lys Pro Thr Pro Val Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  46
<211>  118
<212>  PRT
<213>  Hepatitis B virus

<400>  46

Met Gly Leu Ser Trp Thr Val Pro Leu Glu Trp Gly Lys Asn Leu Ser 
1               5                   10                  15      


Ala Ser Asn Pro Leu Gly Phe Leu Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp Asp Phe Asn Pro Lys Lys 
        35                  40                  45              


Asp Pro Trp Pro Glu Ala Asn Lys Val Gly Val Gly Ala Tyr Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ser 
65                  70                  75                  80  


Gln Gly Thr Leu Thr Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Ser His Pro Gln Ala 
        115             


<210>  47
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  47

Met Gly Gln Asn His Ser Val Thr Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Leu Phe Arg Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Glu Ala Thr Lys Val Gly 
        35                  40                  45              


Val Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Leu Pro Ala Ala 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Lys Ala Thr Pro 
                85                  90                  95      


Ile Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  48
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  48

Met Gly Ala Pro Leu Ser Thr Ala Arg Arg Gly Met Gly Gln Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Leu Phe Arg Ala Asn Ser Ser Ser Pro Asp Trp Asp Phe Asn Thr Asn 
        35                  40                  45              


Lys Asp Asn Trp Pro Met Ala Asn Lys Val Gly Val Gly Gly Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Thr Ser Pro Pro Asp Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Arg Ser Gly Arg Lys Pro Thr Pro Val Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  49
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  49

Met Gly Gln Asn Leu Ser Val Ser Asn Pro Leu Gly Phe Phe Pro Glu 
1               5                   10                  15      


His Gln Leu Asp Pro Leu Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Glu Ala Thr Lys Val Gly 
        35                  40                  45              


Val Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Val Thr Thr Ile Leu Pro Ala Val 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro 
                85                  90                  95      


Ile Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  50
<211>  105
<212>  PRT
<213>  Hepatitis B virus

<400>  50

Met Gly Leu Asn Gln Ser Thr Phe Pro Leu Gly Phe Phe Pro Ser His 
1               5                   10                  15      


Gln Leu Asp Pro Leu Phe Lys Ala Asn Ala Gly Ser Ala Asp Trp Asp 
            20                  25                  30          


Lys Pro Lys Asp Pro Trp Pro Gln Ala His Asp Thr Ala Val Gly Ala 
        35                  40                  45              


Phe Gly Pro Gly Leu Val Pro Pro His Gly Gly Leu Leu Gly Trp Ser 
    50                  55                  60                  


Ser Gln Ala Gln Gly Leu Ser Val Thr Val Pro Asp Thr Pro Pro Pro 
65                  70                  75                  80  


Pro Ser Thr Asn Arg Asp Lys Gly Arg Lys Pro Thr Pro Ala Thr Pro 
                85                  90                  95      


Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105 


<210>  51
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV preS consensus sequence (for amino acid positions (-11) to 
       48)

<400>  51

Met Gly Gly Trp Ser Ser Thr Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Arg Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
        35                  40                  45              


Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
    50                  55                  


