                         SEQUENCE LISTING

<110>  Wake Forest University Health Sciences
       University College Dublin
       Gallagher, Patricia E.
       Tallant, E. Ann
       Paradisi, Francesca
       Chappell, Mark C.
 
<120>  ANGIOTENSIN-(1-7) ANALOGS AND METHODS RELATING THERETO

<130>  1032496

<150>  US 62/266,410
<151>  2015-12-11

<150>  CA 2,914,601
<151>  2015-12-11

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog

<400>  1

Asp Arg Val Tyr Ile His Pro 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  2

Asp Xaa Val Tyr Ile His Pro 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  3

Asp Arg Xaa Tyr Ile His Pro 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  4

Asp Arg Val Xaa Ile His Pro 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  5

Asp Arg Val Tyr Xaa His Pro 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  6

Asp Arg Val Tyr Ile Xaa Pro 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  7

Asp Xaa Xaa Tyr Ile His Pro 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  8

Asp Xaa Val Xaa Ile His Pro 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  9

Asp Xaa Val Tyr Xaa His Pro 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  10

Asp Xaa Val Tyr Ile Xaa Pro 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  11

Asp Arg Xaa Xaa Ile His Pro 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  12

Asp Arg Xaa Tyr Xaa His Pro 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  13

Asp Arg Xaa Tyr Ile Xaa Pro 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (4)..(5)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  14

Asp Arg Val Xaa Xaa His Pro 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  15

Asp Arg Val Xaa Ile Xaa Pro 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  Xaa is cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<400>  16

Asp Arg Val Tyr Xaa Xaa Pro 
1               5           


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ang-(1-7) peptide/analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa may be absent or present; if present, Xaa is norleucine 
       (Nle), Leu, Ala, norvaline (Nva), azidohomoalanine (Aha), or 
       2-Aminobutyric acid (Abu)

<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  may be cyclic peptide with position 1 Xaa and position 9 Xaa 
       joined; may be cyclic peptide with position 2 Xaa and position 9 
       Xaa joined

<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  when cyclized peptide - lactam bridge between Xaa at position 1 
       and Xaa at position 9 or between Xaa at position 2 and Xaa at 
       position 9

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Asp, N-methyl aspartic acid (NMeD), Ala or N-methyl 
       alanaine (NMeA)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Arg, N-methyl arginine (NMeR) or 
       cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Val, N-methyl valine (NMeV), Ala, N-methyl alanine (NMeA) 
       or cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Tyr, N-methyl tyrosine (NMeY), Phe, N-methyl phenylalanine
       (NMeF), Ala, N-methyl alanine (NMeA) or 
       cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Ile, N-methyl isoleucine (NMeI), Ala, N-methyl alanine 
       (NMeA), Leu, N-methyl leucine (NMeL) or 
       cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is His, N-methyl histidine (NMeH), Ala, N-methyl alanine 
       (NMeA) or cis-3-(aminomethyl)cyclobutanecarboxylic acid (ACCA)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Pro, N-methyl proline (NMeP), Ala or N-methyl alanine 
       (NMeA)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys, ornithine (Orn), 2,3-diaminopropionic acid (Dap), 
       2,4-diaminobutyric acid (Dab) or N-methyl lysine (NMe-K); Xaa may
       be amidated if residue 10 absent

<220>
<221>  MOD_RES
<222>  (10)..(11)
<223>  Xaa may be absent, present as a single amino acid (D-valine (dV) 
       or D-proline (dP)) or present as two amino acids 
       (D-valine-D-proline (dV-dP))

<400>  17

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


