                         SEQUENCE LISTING

<110>  Sanford Health
       Egland, Kristi
       Evans, Rick
       Pottala, James V.
 
<120>  Reagents and Methods for Monitoring Breast Cancer Therapy

<130>  15-460-PCT

<150>  62/266189
<151>  2015-12-11

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His 
1               5                   10                  15      


Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr 
            20                  25                  30          


Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser 
        35                  40                  45              


Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu 
    50                  55                  60                  


Ser Arg Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys 
65                  70                  75                  80  


Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln 
                85                  90                  95      


Gln Arg His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser 
            100                 105                 110         


Gln Phe Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys 
        115                 120                 125             


Pro Ala Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro 
    130                 135                 140                 


Ala His Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu 
145                 150                 155                 160 


Leu Phe Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro 
                165                 170                 175     


Gln Gly Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly 
            180                 185                 190         


Gly Trp Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn 
        195                 200                 205             


Arg Pro Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu 
    210                 215                 220                 


Phe Trp Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn 
225                 230                 235                 240 


Ser Arg Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu 
                245                 250                 255     


Leu Gln Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu 
            260                 265                 270         


Gln Leu Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro 
        275                 280                 285             


Pro Ser Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp 
    290                 295                 300                 


Leu Arg Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp 
305                 310                 315                 320 


Phe Gly Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser 
                325                 330                 335     


Ile Pro Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr 
            340                 345                 350         


Trp Arg Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln 
        355                 360                 365             


Pro Met Ala Ala Glu Ala Ala Ser 
    370                 375     


<210>  2
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn 
1               5                   10                  15      


Leu Pro Pro Pro Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val 
            20                  25                  30          


Ser Ala Ala Pro Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr 
        35                  40                  45              


Ile Asp Asn Tyr Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly 
    50                  55                  60                  


Thr Asp Glu Tyr Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val 
65                  70                  75                  80  


Gln Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His 
                85                  90                  95      


Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser 
            100                 105                 110         


Ser Asp Gln Asn His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu 
        115                 120                 125             


Ser Phe Gly Asn Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr 
    130                 135                 140                 


Thr Leu Ser Ser Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val 
145                 150                 155                 160 


Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His 
                165                 170                 175     


Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys 
            180                 185                 190         


Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
        195                 200                 205             


Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His 
    210                 215                 220                 


Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln Arg His 
225                 230                 235             


<210>  3
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Arg Leu Asp Cys Val Lys Ala Ser Asp Gln Cys Leu Lys Glu Gln 
1               5                   10                  15      


Ser Cys Ser Thr Lys Tyr Arg Thr Leu Arg Gln Cys Val Ala Gly Lys 
            20                  25                  30          


Glu Thr Asn Phe Ser Leu Ala Ser Gly Leu Glu Ala Lys Asp Glu Cys 
        35                  40                  45              


Arg Ser Ala Met Glu Ala Leu Lys Gln Lys Ser Leu Tyr Asn Cys Arg 
    50                  55                  60                  


Cys Lys Arg Gly Met Lys Lys Glu Lys Asn Cys Leu Arg Ile Tyr Trp 
65                  70                  75                  80  


Ser Met Tyr Gln Ser Leu Gln Gly Asn Asp Leu Leu Glu Asp Ser Pro 
                85                  90                  95      


Tyr Glu Pro Val Asn Ser Arg Leu Ser Asp Ile Phe Arg Val Val Pro 
            100                 105                 110         


Phe Ile Ser Asp Val Phe Gln Gln Val Glu His Ile Pro Lys Gly Asn 
        115                 120                 125             


Asn Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asp Asp Ile Cys Lys 
    130                 135                 140                 


Lys Tyr Arg Ser Ala Tyr Ile Thr Pro Cys Thr Thr Ser Val Ser Asn 
145                 150                 155                 160 


Asp Val Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
                165                 170                 175     


Asp Lys Val Pro Ala Lys His Ser Tyr Gly Met Leu Phe Cys Ser Cys 
            180                 185                 190         


Arg Asp Ile Ala Cys Thr Glu Arg Arg Arg Gln Thr Ile Val Pro Val 
        195                 200                 205             


Cys Ser Tyr Glu Glu Arg Glu Lys Pro Asn Cys Leu Asn Leu Gln Asp 
    210                 215                 220                 


Ser Cys Lys Thr Asn Tyr Ile Cys Arg Ser Arg Leu Ala Asp Phe Phe 
225                 230                 235                 240 


Thr Asn Cys Gln Pro Glu Ser Arg Ser Val Ser Ser Cys Leu Lys Glu 
                245                 250                 255     


Asn Tyr Ala Asp Cys Leu Leu Ala Tyr Ser Gly Leu Ile Gly Thr Val 
            260                 265                 270         


Met Thr Pro Asn Tyr Ile Asp Ser Ser Ser Leu Ser Val Ala Pro Trp 
        275                 280                 285             


Cys Asp Cys Ser Asn Ser Gly Asn Asp Leu Glu Glu Cys Leu Lys Phe 
    290                 295                 300                 


Leu Asn Phe Phe Lys Asp Asn Thr Cys Leu Lys Asn Ala Ile Gln Ala 
305                 310                 315                 320 


Phe Gly Asn Gly Ser Asp Val Thr Val Trp Gln Pro Ala Phe Pro Val 
                325                 330                 335     


Gln Thr Thr Thr Ala Thr Thr Thr Thr Ala Leu Arg Val Lys Asn Lys 
            340                 345                 350         


Pro Leu Gly Pro Ala Gly Ser Glu Asn Glu Ile Pro Thr His Val Leu 
        355                 360                 365             


Pro Pro Cys Ala Asn Leu Gln Ala Gln Lys Leu Lys Ser Asn Val Ser 
    370                 375                 380                 


Gly Asn Thr His Leu Cys Ile Ser Asn Gly Asn Tyr Glu Lys Glu Gly 
385                 390                 395                 400 


Leu Gly Ala Ser Ser His Ile Thr Thr Lys Ser Met Ala Ala Pro Pro 
                405                 410                 415     


Ser Cys Gly Leu Ser Pro Leu Leu Val Leu Val Val Thr Ala Leu Ser 
            420                 425                 430         


Thr Leu Leu Ser Leu Thr Glu Thr Ser 
        435                 440     


<210>  4
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu Asp 
1               5                   10                  15      


Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys Trp 
            20                  25                  30          


Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp Ala 
        35                  40                  45              


His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr Ser 
    50                  55                  60                  


Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His His 
65                  70                  75                  80  


Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys Phe 
                85                  90                  95      


Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp Ser 
            100                 105                 110         


Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp Gly 
        115                 120                 125             


Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
    130                 135                 140                 


Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr Arg 
145                 150                 155                 160 


Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro Ala 
                165                 170                 175     


Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys Pro 
            180                 185                 190         


Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu Pro 
        195                 200                 205             


Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys Ser 
    210                 215                 220                 


Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln 
225                 230                 235                 240 


Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys 
                245                 250                 255     


Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser 
            260                 265                 270         


Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly 
        275                 280                 285             


Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys 
    290                 295                 300                 


Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu Gln 
305                 310                 315                 320 


Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser 
                325                 330                 335     


Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val 
            340                 345                 350         


Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu 
        355                 360                 365             


Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His Gln 
    370                 375                 380                 


His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys Gln 
385                 390                 395                 400 


Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg Arg 
                405                 410                 415     


Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr Ser 
            420                 425                 430         


Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala 
        435                 440                 445             


Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys 
    450                 455                 460                 


Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys 
465                 470                 475                 480 


Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro His 
                485                 490                 495     


Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp 
            500                 505                 510         


Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro 
        515                 520                 525             


Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala 
    530                 535                 540                 


Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu Ala 
545                 550                 555                 560 


Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu Leu 
                565                 570                 575     


<210>  5
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  5

His Pro Asp Arg Ile Ile Phe Pro Asn His Ala Cys Glu Asp Pro Pro 
1               5                   10                  15      


Ala Val Leu Leu Glu Val Gln Gly Thr Leu Gln Arg Pro Leu Val Arg 
            20                  25                  30          


Asp Ser Arg Thr Ser Pro Ala Asn Cys Thr Trp Leu Ile Leu Gly Ser 
        35                  40                  45              


Lys Glu Gln Thr Val Thr Ile Arg Phe Gln Lys Leu His Leu Ala Cys 
    50                  55                  60                  


Gly Ser Glu Arg Leu Thr Leu Arg Ser Pro Leu Gln Pro Leu Ile Ser 
65                  70                  75                  80  


Leu Cys Glu Ala Pro Pro Ser Pro Leu Gln Leu Pro Gly Gly Asn Val 
                85                  90                  95      


Thr Ile Thr Tyr Ser Tyr Ala Gly Ala Arg Ala Pro Met Gly Gln Gly 
            100                 105                 110         


Phe Leu Leu Ser Tyr Ser Gln Asp Trp Leu Met Cys Leu Gln Glu Glu 
        115                 120                 125             


Phe Gln Cys Leu Asn His Arg Cys Val Ser Ala Val Gln Arg Cys Asp 
    130                 135                 140                 


Gly Val Asp Ala Cys Gly Asp Gly Ser Asp Glu Ala Gly Cys Ser Ser 
145                 150                 155                 160 


Asp Pro Phe Pro Gly Leu Thr Pro Arg Pro Val Pro Ser Leu Pro Cys 
                165                 170                 175     


Asn Val Thr Leu Glu Asp Phe Tyr Gly Val Phe Ser Ser Pro Gly Tyr 
            180                 185                 190         


Thr His Leu Ala Ser Val Ser His Pro Gln Ser Cys His Trp Leu Leu 
        195                 200                 205             


Asp Pro His Asp Gly Arg Arg Leu Ala Val Arg Phe Thr Ala Leu Asp 
    210                 215                 220                 


Leu Gly Phe Gly Asp Ala Val His Val Tyr Asp Gly Pro Gly Pro Pro 
225                 230                 235                 240 


Glu Ser Ser Arg Leu Leu Arg Ser Leu Thr His Phe Ser Asn Gly Lys 
                245                 250                 255     


Ala Val Thr Val Glu Thr Leu Ser Gly Gln Ala Val Val Ser Tyr His 
            260                 265                 270         


Thr Val Ala Trp Ser Asn Gly Arg Gly Phe Asn Ala Thr Tyr His Val 
        275                 280                 285             


Arg Gly Tyr Cys Leu Pro Trp Asp Arg Pro Cys Gly Leu Gly Ser Gly 
    290                 295                 300                 


Leu Gly Ala Gly Glu Gly Leu Gly Glu Arg Cys Tyr Ser Glu Ala Gln 
305                 310                 315                 320 


Arg Cys Asp Gly Ser Trp Asp Cys Ala Asp Gly Thr Asp Glu Glu Asp 
                325                 330                 335     


Cys Pro Gly Cys Pro Pro Gly His Phe Pro Cys Gly Ala Ala Gly Thr 
            340                 345                 350         


Ser Gly Ala Thr Ala Cys Tyr Leu Pro Ala Asp Arg Cys Asn Tyr Gln 
        355                 360                 365             


Thr Phe Cys Ala Asp Gly Ala Asp Glu Arg Arg Cys Arg His Cys Gln 
    370                 375                 380                 


Pro Gly Asn Phe Arg Cys Arg Asp Glu Lys Cys Val Tyr Glu Thr Trp 
385                 390                 395                 400 


Val Cys Asp Gly Gln Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp 
                405                 410                 415     


Cys Ser Tyr Val Leu Pro Arg Lys 
            420                 


<210>  6
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  6

Trp Ser Pro Gln Glu Glu Asp Arg Ile Ile Glu Gly Gly Ile Tyr Asp 
1               5                   10                  15      


Ala Asp Leu Asn Asp Glu Arg Val Gln Arg Ala Leu His Phe Val Ile 
            20                  25                  30          


Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr Arg Arg Leu Leu 
        35                  40                  45              


Arg Val Leu Arg Ala Arg Glu Gln Ile Val Gly Gly Val Asn Tyr Phe 
    50                  55                  60                  


Phe Asp Ile Glu Val Gly Arg Thr Ile Cys Thr Lys Ser Gln Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu Gln Lys Lys Gln 
                85                  90                  95      


Leu Cys Ser Phe Gln Ile Tyr Glu Val Pro Trp Glu Asp Arg Met Ser 
            100                 105                 110         


Leu Val Asn Ser Arg Cys Gln Glu Ala 
        115                 120     


<210>  7
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  8
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  9
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Ser Ala Thr Ala Ser Pro Ser Gly Ser Leu Gly Ala Pro Asp 
1               5                   10                  15      


Cys Pro Glu Val Cys Thr Cys Val Pro Gly Gly Leu Ala Ser Cys Ser 
            20                  25                  30          


Ala Leu Ser Leu Pro Ala Val Pro Pro Gly Leu Ser Leu Arg Leu Arg 
        35                  40                  45              


Ala Leu Leu Leu Asp His Asn Arg Val Arg Ala Leu Pro Pro Gly Ala 
    50                  55                  60                  


Phe Ala Gly Ala Gly Ala Leu Gln Arg Leu Asp Leu Arg Glu Asn Gly 
65                  70                  75                  80  


Leu His Ser Val His Val Arg Ala Phe Trp Gly Leu Gly Ala Leu Gln 
                85                  90                  95      


Leu Leu Asp Leu Ser Ala Asn Gln Leu Glu Ala Leu Ala Pro Gly Thr 
            100                 105                 110         


Phe Ala Pro Leu Arg Ala Leu Arg Asn Leu Ser Leu Ala Gly Asn Arg 
        115                 120                 125             


Leu Ala Arg Leu Glu Pro Ala Ala Leu Gly Ala Leu Pro Leu Leu Arg 
    130                 135                 140                 


Ser Leu Ser Leu Gln Asp Asn Glu Leu Ala Ala Leu Ala Pro Gly Leu 
145                 150                 155                 160 


Leu Gly Arg Leu Pro Ala Leu Asp Ala Leu His Leu Arg Gly Asn Pro 
                165                 170                 175     


Trp Gly Cys Gly Cys Ala Leu Arg Pro Leu Cys Ala Trp Leu Arg Arg 
            180                 185                 190         


His Pro Leu Pro Ala Ser Glu Ala Glu Thr Val Leu Cys Val Trp Pro 
        195                 200                 205             


Gly Arg Leu Thr Leu Ser Pro Leu Thr Ala Phe Ser Asp Ala Ala Phe 
    210                 215                 220                 


Ser His Cys Ala Gln Pro Leu Ala Leu Arg Asp Leu Ala Val 
225                 230                 235             


<210>  10
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val Leu 
1               5                   10                  15      


Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro Arg 
            20                  25                  30          


Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys Asp 
        35                  40                  45              


Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe Gln 
    50                  55                  60                  


Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn Leu 
65                  70                  75                  80  


Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg Leu 
                85                  90                  95      


Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys Ile 
            100                 105                 110         


Lys Cys Val Ala Phe Asp 
        115             


<210>  11
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Pro Lys Pro Ala Thr Val Val Thr Gly Ser Gly His Ala Ser Ser 
1               5                   10                  15      


Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val 
            20                  25                  30          


Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro 
        35                  40                  45              


Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe 
    50                  55                  60                  


Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
65                  70                  75                  80  


Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu 
                85                  90                  95      


Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
            100                 105                 110         


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
        115                 120                 125             


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly 
145 


<210>  12
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly Ile Asp 
1               5                   10                  15      


Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly Arg Val 
            20                  25                  30          


Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser Tyr Val 
        35                  40                  45              


Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn 
    50                  55                  60                  


Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys Arg Leu 
65                  70                  75                  80  


Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile Lys Phe 
                85                  90                  95      


Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile Gln Val 
            100                 105                 110         


Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu Ile Ser 
        115                 120                 125             


Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly 
    130                 135                 140                 


Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp 
145                 150                 155                 160 


Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn 
                165                 170                 175     


Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly 
            180                 185                 190         


Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly 
        195                 200                 205             


Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly Val Phe 
    210                 215                 220                 


Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe 
225                 230                 235                 240 


Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys Lys Thr 
                245                 250                 255     


Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg 
            260                 265                 270         


Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Arg 
        275                 280                 285             


Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu Thr Leu 
    290                 295                 300                 


Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg Ser Thr 
305                 310                 315                 320 


Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys Lys Ser 
                325                 330                 335     


Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys 
            340                 345                 350         


Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro Ser Arg 
        355                 360                 365             


Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala 
    370                 375                 380                 


Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu Leu Asp 
385                 390                 395                 400 


Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val Met Thr 
                405                 410                 415     


Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser Gln Ile 
            420                 425                 430         


Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys Val Tyr 
        435                 440                 445             


Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly Thr Phe 
    450                 455                 460                 


Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu 
465                 470                 475                 480 


Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala Glu 
                485                 490                 495     


Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn Asp Gln 
            500                 505                 510         


Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp Ala Glu 
        515                 520                 525             


Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr Arg 
    530                 535                 540                 


Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile Gly Asp 
545                 550                 555                 560 


Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu Thr Met 
                565                 570                 575     


Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His Gln Asp 
            580                 585                 590         


Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu Glu Ile 
        595                 600                 605             


Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro Pro Pro 
    610                 615                 620                 


Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
625                 630                 635     


