                         SEQUENCE LISTING

<110>  Bio-Rad Laboratories, Inc.
 
<120>  DIMERIC REVERSE TRANSCRIPTASE

<130>  094260-110910PC-1031618

<150>  US 62/264,223
<151>  2015-12-07

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210>  2
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr 
1               5                   10                  15      


Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro Val Leu 
        35                  40                  45              


Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro 
    50                  55                  60                  


Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg Arg Met 
65                  70                  75                  80  


Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His Pro Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile 
                165                 170                 175     


Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu Ala Asp 
        195                 200                 205             


Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu 
        275                 280                 285             


Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln Trp Gly 
                325                 330                 335     


Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu Leu Ser 
            340                 345                 350         


Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu Leu Phe 
        355                 360                 365             


Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln Lys Leu 
    370                 375                 380                 


Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Thr 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro Leu Thr 
            420                 425                 430         


Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro Pro Asn 
        435                 440                 445             


Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu Leu 
    450                 455                 460                 


Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn Pro Ala 
465                 470                 475                 480 


Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser Pro Asp 
                485                 490                 495     


Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro Leu Pro 
            500                 505                 510         


Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile Arg Asn 
        515                 520                 525             


Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu Val Ile 
    530                 535                 540                 


Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala Glu Leu 
545                 550                 555                 560 


Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys Leu Thr 
                565                 570                 575     


Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val His Gly 
            580                 585                 590         


Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys Glu Ile 
        595                 600                 605             


Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe Leu Pro 
    610                 615                 620                 


Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly Asp Ser 
625                 630                 635                 640 


Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys Lys Ala 
                645                 650                 655     


Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu 
            660                 665         


<210>  3
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp 
        675                 680                 685             


Glu His Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly 
    690                 695                 700                 


Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
705                 710                 715                 720 


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
                725                 730                 735     


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala 
            740                 745                 750         


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
        755                 760                 765             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    770                 775                 780                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
785                 790                 795                 800 


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                805                 810                 815     


Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
            820                 825                 830         


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
        835                 840                 845             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
    850                 855                 860                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
865                 870                 875                 880 


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
                885                 890                 895     


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
            900                 905                 910         


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
        915                 920                 925             


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
    930                 935                 940                 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
945                 950                 955                 960 


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
                965                 970                 975     


Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            980                 985                 990         


Arg Leu Trp Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
        995                 1000                 1005             


Leu Thr  Lys Thr Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1010                 1015                 1020             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1025                 1030                 1035             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1040                 1045                 1050             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1055                 1060                 1065             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1070                 1075                 1080             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1085                 1090                 1095             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1100                 1105                 1110             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1115                 1120                 1125             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1130                 1135                 1140             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1145                 1150                 1155             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1160                 1165                 1170             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1175                 1180                 1185             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1190                 1195                 1200             


Tyr Thr  Asp Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1205                 1210                 1215             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1220                 1225                 1230             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1235                 1240                 1245             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1250                 1255                 1260             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1265                 1270                 1275             


Ile Tyr  Arg Arg Arg Gly Leu  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1280                 1285                 1290             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1295                 1300                 1305             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1310                 1315                 1320             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1325                 1330                 1335             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1340                 1345                 1350             


Ser Ser  Ser Ala Ser 
    1355             


<210>  4
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp 
        675                 680                 685             


Glu His Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly 
    690                 695                 700                 


Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
705                 710                 715                 720 


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
                725                 730                 735     


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala 
            740                 745                 750         


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
        755                 760                 765             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    770                 775                 780                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
785                 790                 795                 800 


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                805                 810                 815     


Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
            820                 825                 830         


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
        835                 840                 845             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
    850                 855                 860                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
865                 870                 875                 880 


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
                885                 890                 895     


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
            900                 905                 910         


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
        915                 920                 925             


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
    930                 935                 940                 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
945                 950                 955                 960 


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
                965                 970                 975     


Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            980                 985                 990         


Arg Leu Trp Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
        995                 1000                 1005             


Leu Thr  Lys Thr Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1010                 1015                 1020             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1025                 1030                 1035             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1040                 1045                 1050             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1055                 1060                 1065             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1070                 1075                 1080             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1085                 1090                 1095             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1100                 1105                 1110             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1115                 1120                 1125             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1130                 1135                 1140             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1145                 1150                 1155             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1160                 1165                 1170             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1175                 1180                 1185             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1190                 1195                 1200             


Tyr Thr  Asp Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1205                 1210                 1215             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1220                 1225                 1230             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1235                 1240                 1245             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1250                 1255                 1260             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1265                 1270                 1275             


Ile Tyr  Arg Arg Arg Gly Leu  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1280                 1285                 1290             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1295                 1300                 1305             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1310                 1315                 1320             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1325                 1330                 1335             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1340                 1345                 1350             


Ser Ser  Ser Ala Ser 
    1355             


<210>  5
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp 
        675                 680                 685             


Glu His Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly 
    690                 695                 700                 


Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
705                 710                 715                 720 


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
                725                 730                 735     


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala 
            740                 745                 750         


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
        755                 760                 765             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    770                 775                 780                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
785                 790                 795                 800 


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                805                 810                 815     


Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
            820                 825                 830         


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
        835                 840                 845             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
    850                 855                 860                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
865                 870                 875                 880 


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
                885                 890                 895     


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
            900                 905                 910         


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
        915                 920                 925             


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
    930                 935                 940                 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
945                 950                 955                 960 


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
                965                 970                 975     


Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            980                 985                 990         


Arg Leu Trp Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
        995                 1000                 1005             


Leu Thr  Lys Thr Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1010                 1015                 1020             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1025                 1030                 1035             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1040                 1045                 1050             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1055                 1060                 1065             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1070                 1075                 1080             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1085                 1090                 1095             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1100                 1105                 1110             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1115                 1120                 1125             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1130                 1135                 1140             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1145                 1150                 1155             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1160                 1165                 1170             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1175                 1180                 1185             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1190                 1195                 1200             


Tyr Thr  Asn Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1205                 1210                 1215             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1220                 1225                 1230             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1235                 1240                 1245             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1250                 1255                 1260             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1265                 1270                 1275             


Ile Tyr  Arg Arg Arg Gly Leu  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1280                 1285                 1290             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1295                 1300                 1305             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1310                 1315                 1320             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1325                 1330                 1335             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1340                 1345                 1350             


Ser Ser  Ser Ala Ser 
    1355             


<210>  6
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu 
        675                 680                 685             


Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys 
    690                 695                 700                 


Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His 
705                 710                 715                 720 


Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile 
                725                 730                 735     


Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys 
            740                 745                 750         


Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln 
        755                 760                 765             


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys 
    770                 775                 780                 


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
785                 790                 795                 800 


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu 
                805                 810                 815     


Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
            820                 825                 830         


Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu 
        835                 840                 845             


Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg 
    850                 855                 860                 


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu 
865                 870                 875                 880 


His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu 
                885                 890                 895     


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu 
            900                 905                 910         


Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly 
        915                 920                 925             


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr 
    930                 935                 940                 


Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala 
945                 950                 955                 960 


Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln 
                965                 970                 975     


Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro 
            980                 985                 990         


Gly Phe Ala Glu Leu Ala Ala Pro  Leu Tyr Pro Leu Thr  Arg Pro Gly 
        995                 1000                 1005             


Thr Leu  Phe Gln Trp Gly Thr  Glu Gln Gln Leu Ala  Phe Glu Asn 
    1010                 1015                 1020             


Ile Arg  Lys Ala Leu Leu Ser  Ser Pro Ala Leu Gly  Leu Pro Asp 
    1025                 1030                 1035             


Ile Thr  Lys Pro Phe Glu Leu  Phe Ile Asp Glu Asn  Ser Gly Phe 
    1040                 1045                 1050             


Ala Lys  Gly Val Leu Val Gln  Lys Leu Gly Pro Trp  Lys Arg Pro 
    1055                 1060                 1065             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Thr Val Ala  Ser Gly Trp 
    1070                 1075                 1080             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Ile  Leu Val Lys 
    1085                 1090                 1095             


Asp Ala  Gly Lys Leu Thr Leu  Gly Gln Pro Leu Thr  Ile Leu Thr 
    1100                 1105                 1110             


Ser His  Pro Val Glu Ala Leu  Val Arg Gln Pro Pro  Asn Lys Trp 
    1115                 1120                 1125             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Met  Leu Leu Asp 
    1130                 1135                 1140             


Ala Glu  Arg Val His Phe Gly  Pro Thr Val Ser Leu  Asn Pro Ala 
    1145                 1150                 1155             


Thr Leu  Leu Pro Leu Pro Ser  Gly Lys Pro Pro Arg  Leu Ser Pro 
    1160                 1165                 1170             


Asp Leu  Ala Glu Thr Met Ala  Gln Thr Asp Leu Thr  Asp Gln Pro 
    1175                 1180                 1185             


Leu Pro  Asp Ala Asp Leu Thr  Trp Tyr Thr Asp Gly  Ser Ser Phe 
    1190                 1195                 1200             


Ile Arg  Asn Gly Glu Arg Lys  Ala Gly Ala Ala Val  Thr Thr Glu 
    1205                 1210                 1215             


Ser Glu  Val Ile Trp Ala Ala  Ser Leu Pro Pro Gly  Thr Ser Ala 
    1220                 1225                 1230             


Gln Arg  Ala Glu Leu Ile Ala  Leu Thr Gln Ala Leu  Lys Met Ala 
    1235                 1240                 1245             


Lys Gly  Lys Lys Leu Thr Val  Tyr Thr Asp Ser Arg  Tyr Ala Phe 
    1250                 1255                 1260             


Ala Thr  Ala His Val His Gly  Glu Ile Tyr Arg Arg  Arg Gly Leu 
    1265                 1270                 1275             


Leu Thr  Ser Glu Gly Lys Glu  Ile Lys Asn Lys Asn  Glu Ile Leu 
    1280                 1285                 1290             


Ala Leu  Leu Glu Ala Leu Phe  Leu Pro Lys Arg Leu  Ser Ile Ile 
    1295                 1300                 1305             


His Cys  Pro Gly His Gln Lys  Gly Asp Ser Pro Gln  Ala Lys Gly 
    1310                 1315                 1320             


Asn Arg  Leu Ala Asp Asp Thr  Ala Lys Lys Ala Ala  Thr Glu Thr 
    1325                 1330                 1335             


Gln Ser  Ser Leu Thr Ile Leu  Ser Ser Ser Ala Ser  
    1340                 1345                 1350 


<210>  7
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asn Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu 
        675                 680                 685             


Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys 
    690                 695                 700                 


Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His 
705                 710                 715                 720 


Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile 
                725                 730                 735     


Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys 
            740                 745                 750         


Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln 
        755                 760                 765             


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys 
    770                 775                 780                 


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
785                 790                 795                 800 


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu 
                805                 810                 815     


Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
            820                 825                 830         


Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu 
        835                 840                 845             


Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg 
    850                 855                 860                 


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu 
865                 870                 875                 880 


His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu 
                885                 890                 895     


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu 
            900                 905                 910         


Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly 
        915                 920                 925             


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr 
    930                 935                 940                 


Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala 
945                 950                 955                 960 


Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln 
                965                 970                 975     


Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro 
            980                 985                 990         


Gly Phe Ala Glu Leu Ala Ala Pro  Leu Tyr Pro Leu Thr  Arg Pro Gly 
        995                 1000                 1005             


Thr Leu  Phe Gln Trp Gly Thr  Glu Gln Gln Leu Ala  Phe Glu Asn 
    1010                 1015                 1020             


Ile Arg  Lys Ala Leu Leu Ser  Ser Pro Ala Leu Gly  Leu Pro Asp 
    1025                 1030                 1035             


Ile Thr  Lys Pro Phe Glu Leu  Phe Ile Asp Glu Asn  Ser Gly Phe 
    1040                 1045                 1050             


Ala Lys  Gly Val Leu Val Gln  Lys Leu Gly Pro Trp  Lys Arg Pro 
    1055                 1060                 1065             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Thr Val Ala  Ser Gly Trp 
    1070                 1075                 1080             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Ile  Leu Val Lys 
    1085                 1090                 1095             


Asp Ala  Gly Lys Leu Thr Leu  Gly Gln Pro Leu Thr  Ile Leu Thr 
    1100                 1105                 1110             


Ser His  Pro Val Glu Ala Leu  Val Arg Gln Pro Pro  Asn Lys Trp 
    1115                 1120                 1125             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Met  Leu Leu Asp 
    1130                 1135                 1140             


Ala Glu  Arg Val His Phe Gly  Pro Thr Val Ser Leu  Asn Pro Ala 
    1145                 1150                 1155             


Thr Leu  Leu Pro Leu Pro Ser  Gly Lys Pro Pro Arg  Leu Ser Pro 
    1160                 1165                 1170             


Asp Leu  Ala Glu Thr Met Ala  Gln Thr Asp Leu Thr  Asp Gln Pro 
    1175                 1180                 1185             


Leu Pro  Asp Ala Asp Leu Thr  Trp Tyr Thr Asp Gly  Ser Ser Phe 
    1190                 1195                 1200             


Ile Arg  Asn Gly Glu Arg Lys  Ala Gly Ala Ala Val  Thr Thr Glu 
    1205                 1210                 1215             


Ser Glu  Val Ile Trp Ala Ala  Ser Leu Pro Pro Gly  Thr Ser Ala 
    1220                 1225                 1230             


Gln Arg  Ala Glu Leu Ile Ala  Leu Thr Gln Ala Leu  Lys Met Ala 
    1235                 1240                 1245             


Lys Gly  Lys Lys Leu Thr Val  Tyr Thr Asp Ser Arg  Tyr Ala Phe 
    1250                 1255                 1260             


Ala Thr  Ala His Val His Gly  Glu Ile Tyr Arg Arg  Arg Gly Leu 
    1265                 1270                 1275             


Leu Thr  Ser Glu Gly Lys Glu  Ile Lys Asn Lys Asn  Glu Ile Leu 
    1280                 1285                 1290             


Ala Leu  Leu Glu Ala Leu Phe  Leu Pro Lys Arg Leu  Ser Ile Ile 
    1295                 1300                 1305             


His Cys  Pro Gly His Gln Lys  Gly Asp Ser Pro Gln  Ala Lys Gly 
    1310                 1315                 1320             


Asn Arg  Leu Ala Asp Asp Thr  Ala Lys Lys Ala Ala  Thr Glu Thr 
    1325                 1330                 1335             


Gln Ser  Ser Leu Thr Ile Leu  Ser Ser Ser Ala Ser  
    1340                 1345                 1350 


<210>  8
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asn Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu 
        675                 680                 685             


Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys 
    690                 695                 700                 


Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His 
705                 710                 715                 720 


Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile 
                725                 730                 735     


Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys 
            740                 745                 750         


Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln 
        755                 760                 765             


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys 
    770                 775                 780                 


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
785                 790                 795                 800 


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu 
                805                 810                 815     


Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
            820                 825                 830         


Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu 
        835                 840                 845             


Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg 
    850                 855                 860                 


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu 
865                 870                 875                 880 


His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu 
                885                 890                 895     


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu 
            900                 905                 910         


Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly 
        915                 920                 925             


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr 
    930                 935                 940                 


Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala 
945                 950                 955                 960 


Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln 
                965                 970                 975     


Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro 
            980                 985                 990         


Gly Phe Ala Glu Leu Ala Ala Pro  Leu Tyr Pro Leu Thr  Arg Pro Gly 
        995                 1000                 1005             


Thr Leu  Phe Gln Trp Gly Thr  Glu Gln Gln Leu Ala  Phe Glu Asn 
    1010                 1015                 1020             


Ile Arg  Lys Ala Leu Leu Ser  Ser Pro Ala Leu Gly  Leu Pro Asp 
    1025                 1030                 1035             


Ile Thr  Lys Pro Phe Glu Leu  Phe Ile Asp Glu Asn  Ser Gly Phe 
    1040                 1045                 1050             


Ala Lys  Gly Val Leu Val Gln  Lys Leu Gly Pro Trp  Lys Arg Pro 
    1055                 1060                 1065             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Thr Val Ala  Ser Gly Trp 
    1070                 1075                 1080             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Ile  Leu Val Lys 
    1085                 1090                 1095             


Asp Ala  Gly Lys Leu Thr Leu  Gly Gln Pro Leu Thr  Ile Leu Thr 
    1100                 1105                 1110             


Ser His  Pro Val Glu Ala Leu  Val Arg Gln Pro Pro  Asn Lys Trp 
    1115                 1120                 1125             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Met  Leu Leu Asp 
    1130                 1135                 1140             


Ala Glu  Arg Val His Phe Gly  Pro Thr Val Ser Leu  Asn Pro Ala 
    1145                 1150                 1155             


Thr Leu  Leu Pro Leu Pro Ser  Gly Lys Pro Pro Arg  Leu Ser Pro 
    1160                 1165                 1170             


Asp Leu  Ala Glu Thr Met Ala  Gln Thr Asp Leu Thr  Asp Gln Pro 
    1175                 1180                 1185             


Leu Pro  Asp Ala Asp Leu Thr  Trp Tyr Thr Asn Gly  Ser Ser Phe 
    1190                 1195                 1200             


Ile Arg  Asn Gly Glu Arg Lys  Ala Gly Ala Ala Val  Thr Thr Glu 
    1205                 1210                 1215             


Ser Glu  Val Ile Trp Ala Ala  Ser Leu Pro Pro Gly  Thr Ser Ala 
    1220                 1225                 1230             


Gln Arg  Ala Glu Leu Ile Ala  Leu Thr Gln Ala Leu  Lys Met Ala 
    1235                 1240                 1245             


Lys Gly  Lys Lys Leu Thr Val  Tyr Thr Asp Ser Arg  Tyr Ala Phe 
    1250                 1255                 1260             


Ala Thr  Ala His Val His Gly  Glu Ile Tyr Arg Arg  Arg Gly Leu 
    1265                 1270                 1275             


Leu Thr  Ser Glu Gly Lys Glu  Ile Lys Asn Lys Asn  Glu Ile Leu 
    1280                 1285                 1290             


Ala Leu  Leu Glu Ala Leu Phe  Leu Pro Lys Arg Leu  Ser Ile Ile 
    1295                 1300                 1305             


His Cys  Pro Gly His Gln Lys  Gly Asp Ser Pro Gln  Ala Lys Gly 
    1310                 1315                 1320             


Asn Arg  Leu Ala Asp Asp Thr  Ala Lys Lys Ala Ala  Thr Glu Thr 
    1325                 1330                 1335             


Gln Ser  Ser Leu Thr Ile Leu  Ser Ser Ser Ala Ser  
    1340                 1345                 1350 


<210>  9
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu 
        675                 680                 685             


His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu 
    690                 695                 700                 


Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala 
705                 710                 715                 720 


Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro 
                725                 730                 735     


Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile 
            740                 745                 750         


Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys 
        755                 760                 765             


Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr 
    770                 775                 780                 


Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val 
785                 790                 795                 800 


Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly 
                805                 810                 815     


Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            820                 825                 830         


Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe 
        835                 840                 845             


Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr 
    850                 855                 860                 


Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala 
865                 870                 875                 880 


Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile 
                885                 890                 895     


Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu 
            900                 905                 910         


Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu 
        915                 920                 925             


Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val 
    930                 935                 940                 


Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu 
945                 950                 955                 960 


Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg 
                965                 970                 975     


Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile 
            980                 985                 990         


Pro Gly Phe Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Thr 
        995                 1000                 1005             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1010                 1015                 1020             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1025                 1030                 1035             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1055                 1060                 1065             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1070                 1075                 1080             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1085                 1090                 1095             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1100                 1105                 1110             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1115                 1120                 1125             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1130                 1135                 1140             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1145                 1150                 1155             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1160                 1165                 1170             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1175                 1180                 1185             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1190                 1195                 1200             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1205                 1210                 1215             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1220                 1225                 1230             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1235                 1240                 1245             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1250                 1255                 1260             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1265                 1270                 1275             


Arg Gly  Leu Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1280                 1285                 1290             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1295                 1300                 1305             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1310                 1315                 1320             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1325                 1330                 1335             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  10
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asn Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu 
        675                 680                 685             


His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu 
    690                 695                 700                 


Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala 
705                 710                 715                 720 


Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro 
                725                 730                 735     


Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile 
            740                 745                 750         


Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys 
        755                 760                 765             


Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr 
    770                 775                 780                 


Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val 
785                 790                 795                 800 


Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly 
                805                 810                 815     


Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            820                 825                 830         


Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe 
        835                 840                 845             


Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr 
    850                 855                 860                 


Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala 
865                 870                 875                 880 


Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile 
                885                 890                 895     


Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu 
            900                 905                 910         


Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu 
        915                 920                 925             


Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val 
    930                 935                 940                 


Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu 
945                 950                 955                 960 


Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg 
                965                 970                 975     


Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile 
            980                 985                 990         


Pro Gly Phe Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Thr 
        995                 1000                 1005             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1010                 1015                 1020             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1025                 1030                 1035             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1055                 1060                 1065             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1070                 1075                 1080             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1085                 1090                 1095             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1100                 1105                 1110             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1115                 1120                 1125             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1130                 1135                 1140             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1145                 1150                 1155             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1160                 1165                 1170             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1175                 1180                 1185             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1190                 1195                 1200             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1205                 1210                 1215             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1220                 1225                 1230             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1235                 1240                 1245             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1250                 1255                 1260             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1265                 1270                 1275             


Arg Gly  Leu Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1280                 1285                 1290             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1295                 1300                 1305             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1310                 1315                 1320             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1325                 1330                 1335             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  11
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asn Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu 
        675                 680                 685             


His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu 
    690                 695                 700                 


Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala 
705                 710                 715                 720 


Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro 
                725                 730                 735     


Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile 
            740                 745                 750         


Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys 
        755                 760                 765             


Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr 
    770                 775                 780                 


Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val 
785                 790                 795                 800 


Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly 
                805                 810                 815     


Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            820                 825                 830         


Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe 
        835                 840                 845             


Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr 
    850                 855                 860                 


Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala 
865                 870                 875                 880 


Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile 
                885                 890                 895     


Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu 
            900                 905                 910         


Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu 
        915                 920                 925             


Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val 
    930                 935                 940                 


Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu 
945                 950                 955                 960 


Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg 
                965                 970                 975     


Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile 
            980                 985                 990         


Pro Gly Phe Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Thr 
        995                 1000                 1005             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1010                 1015                 1020             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1025                 1030                 1035             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1055                 1060                 1065             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1070                 1075                 1080             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1085                 1090                 1095             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1100                 1105                 1110             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1115                 1120                 1125             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1130                 1135                 1140             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1145                 1150                 1155             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1160                 1165                 1170             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1175                 1180                 1185             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asn Gly 
    1190                 1195                 1200             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1205                 1210                 1215             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1220                 1225                 1230             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1235                 1240                 1245             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1250                 1255                 1260             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1265                 1270                 1275             


Arg Gly  Leu Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1280                 1285                 1290             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1295                 1300                 1305             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1310                 1315                 1320             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1325                 1330                 1335             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  12
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu 
        675                 680                 685             


Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp 
    690                 695                 700                 


Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met 
705                 710                 715                 720 


Gly Met Ala His Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr 
                725                 730                 735     


Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr 
            740                 745                 750         


Gln Gly Ile Lys Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu 
        755                 760                 765             


Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys 
    770                 775                 780                 


Pro Gly Thr Lys Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn 
785                 790                 795                 800 


Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu 
                805                 810                 815     


Leu Ser Thr Leu Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu 
            820                 825                 830         


Lys Asp Ala Phe Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu 
        835                 840                 845             


Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu 
    850                 855                 860                 


Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe 
865                 870                 875                 880 


Asp Glu Ala Leu His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro 
                885                 890                 895     


Ala Leu Val Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala 
            900                 905                 910         


Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu 
        915                 920                 925             


Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu 
    930                 935                 940                 


Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp 
945                 950                 955                 960 


Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys 
                965                 970                 975     


Asn Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg 
            980                 985                 990         


Leu Trp Ile Pro Gly Phe Ala Glu  Leu Ala Ala Pro Leu  Tyr Pro Leu 
        995                 1000                 1005             


Thr Arg  Pro Gly Thr Leu Phe  Gln Trp Gly Thr Glu  Gln Gln Leu 
    1010                 1015                 1020             


Ala Phe  Glu Asn Ile Arg Lys  Ala Leu Leu Ser Ser  Pro Ala Leu 
    1025                 1030                 1035             


Gly Leu  Pro Asp Ile Thr Lys  Pro Phe Glu Leu Phe  Ile Asp Glu 
    1040                 1045                 1050             


Asn Ser  Gly Phe Ala Lys Gly  Val Leu Val Gln Lys  Leu Gly Pro 
    1055                 1060                 1065             


Trp Lys  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Thr Val 
    1070                 1075                 1080             


Ala Ser  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1085                 1090                 1095             


Ile Leu  Val Lys Asp Ala Gly  Lys Leu Thr Leu Gly  Gln Pro Leu 
    1100                 1105                 1110             


Thr Ile  Leu Thr Ser His Pro  Val Glu Ala Leu Val  Arg Gln Pro 
    1115                 1120                 1125             


Pro Asn  Lys Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1130                 1135                 1140             


Met Leu  Leu Asp Ala Glu Arg  Val His Phe Gly Pro  Thr Val Ser 
    1145                 1150                 1155             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Ser Gly  Lys Pro Pro 
    1160                 1165                 1170             


Arg Leu  Ser Pro Asp Leu Ala  Glu Thr Met Ala Gln  Thr Asp Leu 
    1175                 1180                 1185             


Thr Asp  Gln Pro Leu Pro Asp  Ala Asp Leu Thr Trp  Tyr Thr Asp 
    1190                 1195                 1200             


Gly Ser  Ser Phe Ile Arg Asn  Gly Glu Arg Lys Ala  Gly Ala Ala 
    1205                 1210                 1215             


Val Thr  Thr Glu Ser Glu Val  Ile Trp Ala Ala Ser  Leu Pro Pro 
    1220                 1225                 1230             


Gly Thr  Ser Ala Gln Arg Ala  Glu Leu Ile Ala Leu  Thr Gln Ala 
    1235                 1240                 1245             


Leu Lys  Met Ala Lys Gly Lys  Lys Leu Thr Val Tyr  Thr Asp Ser 
    1250                 1255                 1260             


Arg Tyr  Ala Phe Ala Thr Ala  His Val His Gly Glu  Ile Tyr Arg 
    1265                 1270                 1275             


Arg Arg  Gly Leu Leu Thr Ser  Glu Gly Lys Glu Ile  Lys Asn Lys 
    1280                 1285                 1290             


Asn Glu  Ile Leu Ala Leu Leu  Glu Ala Leu Phe Leu  Pro Lys Arg 
    1295                 1300                 1305             


Leu Ser  Ile Ile His Cys Pro  Gly His Gln Lys Gly  Asp Ser Pro 
    1310                 1315                 1320             


Gln Ala  Lys Gly Asn Arg Leu  Ala Asp Asp Thr Ala  Lys Lys Ala 
    1325                 1330                 1335             


Ala Thr  Glu Thr Gln Ser Ser  Leu Thr Ile Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  13
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu 
        675                 680                 685             


Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp 
    690                 695                 700                 


Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met 
705                 710                 715                 720 


Gly Met Ala His Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr 
                725                 730                 735     


Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr 
            740                 745                 750         


Gln Gly Ile Lys Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu 
        755                 760                 765             


Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys 
    770                 775                 780                 


Pro Gly Thr Lys Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn 
785                 790                 795                 800 


Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu 
                805                 810                 815     


Leu Ser Thr Leu Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu 
            820                 825                 830         


Lys Asp Ala Phe Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu 
        835                 840                 845             


Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu 
    850                 855                 860                 


Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe 
865                 870                 875                 880 


Asp Glu Ala Leu His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro 
                885                 890                 895     


Ala Leu Val Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala 
            900                 905                 910         


Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu 
        915                 920                 925             


Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu 
    930                 935                 940                 


Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp 
945                 950                 955                 960 


Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys 
                965                 970                 975     


Asn Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg 
            980                 985                 990         


Leu Trp Ile Pro Gly Phe Ala Glu  Leu Ala Ala Pro Leu  Tyr Pro Leu 
        995                 1000                 1005             


Thr Arg  Pro Gly Thr Leu Phe  Gln Trp Gly Thr Glu  Gln Gln Leu 
    1010                 1015                 1020             


Ala Phe  Glu Asn Ile Arg Lys  Ala Leu Leu Ser Ser  Pro Ala Leu 
    1025                 1030                 1035             


Gly Leu  Pro Asp Ile Thr Lys  Pro Phe Glu Leu Phe  Ile Asp Glu 
    1040                 1045                 1050             


Asn Ser  Gly Phe Ala Lys Gly  Val Leu Val Gln Lys  Leu Gly Pro 
    1055                 1060                 1065             


Trp Lys  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Thr Val 
    1070                 1075                 1080             


Ala Ser  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1085                 1090                 1095             


Ile Leu  Val Lys Asp Ala Gly  Lys Leu Thr Leu Gly  Gln Pro Leu 
    1100                 1105                 1110             


Thr Ile  Leu Thr Ser His Pro  Val Glu Ala Leu Val  Arg Gln Pro 
    1115                 1120                 1125             


Pro Asn  Lys Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1130                 1135                 1140             


Met Leu  Leu Asp Ala Glu Arg  Val His Phe Gly Pro  Thr Val Ser 
    1145                 1150                 1155             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Ser Gly  Lys Pro Pro 
    1160                 1165                 1170             


Arg Leu  Ser Pro Asp Leu Ala  Glu Thr Met Ala Gln  Thr Asp Leu 
    1175                 1180                 1185             


Thr Asp  Gln Pro Leu Pro Asp  Ala Asp Leu Thr Trp  Tyr Thr Asp 
    1190                 1195                 1200             


Gly Ser  Ser Phe Ile Arg Asn  Gly Glu Arg Lys Ala  Gly Ala Ala 
    1205                 1210                 1215             


Val Thr  Thr Glu Ser Glu Val  Ile Trp Ala Ala Ser  Leu Pro Pro 
    1220                 1225                 1230             


Gly Thr  Ser Ala Gln Arg Ala  Glu Leu Ile Ala Leu  Thr Gln Ala 
    1235                 1240                 1245             


Leu Lys  Met Ala Lys Gly Lys  Lys Leu Thr Val Tyr  Thr Asp Ser 
    1250                 1255                 1260             


Arg Tyr  Ala Phe Ala Thr Ala  His Val His Gly Glu  Ile Tyr Arg 
    1265                 1270                 1275             


Arg Arg  Gly Leu Leu Thr Ser  Glu Gly Lys Glu Ile  Lys Asn Lys 
    1280                 1285                 1290             


Asn Glu  Ile Leu Ala Leu Leu  Glu Ala Leu Phe Leu  Pro Lys Arg 
    1295                 1300                 1305             


Leu Ser  Ile Ile His Cys Pro  Gly His Gln Lys Gly  Asp Ser Pro 
    1310                 1315                 1320             


Gln Ala  Lys Gly Asn Arg Leu  Ala Asp Asp Thr Ala  Lys Lys Ala 
    1325                 1330                 1335             


Ala Thr  Glu Thr Gln Ser Ser  Leu Thr Ile Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  14
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu 
        675                 680                 685             


Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp 
    690                 695                 700                 


Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met 
705                 710                 715                 720 


Gly Met Ala His Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr 
                725                 730                 735     


Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr 
            740                 745                 750         


Gln Gly Ile Lys Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu 
        755                 760                 765             


Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys 
    770                 775                 780                 


Pro Gly Thr Lys Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn 
785                 790                 795                 800 


Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu 
                805                 810                 815     


Leu Ser Thr Leu Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu 
            820                 825                 830         


Lys Asp Ala Phe Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu 
        835                 840                 845             


Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu 
    850                 855                 860                 


Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe 
865                 870                 875                 880 


Asp Glu Ala Leu His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro 
                885                 890                 895     


Ala Leu Val Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala 
            900                 905                 910         


Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu 
        915                 920                 925             


Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu 
    930                 935                 940                 


Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp 
945                 950                 955                 960 


Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys 
                965                 970                 975     


Asn Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg 
            980                 985                 990         


Leu Trp Ile Pro Gly Phe Ala Glu  Leu Ala Ala Pro Leu  Tyr Pro Leu 
        995                 1000                 1005             


Thr Arg  Pro Gly Thr Leu Phe  Gln Trp Gly Thr Glu  Gln Gln Leu 
    1010                 1015                 1020             


Ala Phe  Glu Asn Ile Arg Lys  Ala Leu Leu Ser Ser  Pro Ala Leu 
    1025                 1030                 1035             


Gly Leu  Pro Asp Ile Thr Lys  Pro Phe Glu Leu Phe  Ile Asp Glu 
    1040                 1045                 1050             


Asn Ser  Gly Phe Ala Lys Gly  Val Leu Val Gln Lys  Leu Gly Pro 
    1055                 1060                 1065             


Trp Lys  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Thr Val 
    1070                 1075                 1080             


Ala Ser  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1085                 1090                 1095             


Ile Leu  Val Lys Asp Ala Gly  Lys Leu Thr Leu Gly  Gln Pro Leu 
    1100                 1105                 1110             


Thr Ile  Leu Thr Ser His Pro  Val Glu Ala Leu Val  Arg Gln Pro 
    1115                 1120                 1125             


Pro Asn  Lys Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1130                 1135                 1140             


Met Leu  Leu Asp Ala Glu Arg  Val His Phe Gly Pro  Thr Val Ser 
    1145                 1150                 1155             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Ser Gly  Lys Pro Pro 
    1160                 1165                 1170             


Arg Leu  Ser Pro Asp Leu Ala  Glu Thr Met Ala Gln  Thr Asp Leu 
    1175                 1180                 1185             


Thr Asp  Gln Pro Leu Pro Asp  Ala Asp Leu Thr Trp  Tyr Thr Asn 
    1190                 1195                 1200             


Gly Ser  Ser Phe Ile Arg Asn  Gly Glu Arg Lys Ala  Gly Ala Ala 
    1205                 1210                 1215             


Val Thr  Thr Glu Ser Glu Val  Ile Trp Ala Ala Ser  Leu Pro Pro 
    1220                 1225                 1230             


Gly Thr  Ser Ala Gln Arg Ala  Glu Leu Ile Ala Leu  Thr Gln Ala 
    1235                 1240                 1245             


Leu Lys  Met Ala Lys Gly Lys  Lys Leu Thr Val Tyr  Thr Asp Ser 
    1250                 1255                 1260             


Arg Tyr  Ala Phe Ala Thr Ala  His Val His Gly Glu  Ile Tyr Arg 
    1265                 1270                 1275             


Arg Arg  Gly Leu Leu Thr Ser  Glu Gly Lys Glu Ile  Lys Asn Lys 
    1280                 1285                 1290             


Asn Glu  Ile Leu Ala Leu Leu  Glu Ala Leu Phe Leu  Pro Lys Arg 
    1295                 1300                 1305             


Leu Ser  Ile Ile His Cys Pro  Gly His Gln Lys Gly  Asp Ser Pro 
    1310                 1315                 1320             


Gln Ala  Lys Gly Asn Arg Leu  Ala Asp Asp Thr Ala  Lys Lys Ala 
    1325                 1330                 1335             


Ala Thr  Glu Thr Gln Ser Ser  Leu Thr Ile Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  15
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu 
        675                 680                 685             


Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys 
    690                 695                 700                 


Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His 
705                 710                 715                 720 


Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile 
                725                 730                 735     


Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys 
            740                 745                 750         


Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln 
        755                 760                 765             


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys 
    770                 775                 780                 


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
785                 790                 795                 800 


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu 
                805                 810                 815     


Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
            820                 825                 830         


Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu 
        835                 840                 845             


Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg 
    850                 855                 860                 


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu 
865                 870                 875                 880 


His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu 
                885                 890                 895     


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu 
            900                 905                 910         


Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly 
        915                 920                 925             


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr 
    930                 935                 940                 


Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala 
945                 950                 955                 960 


Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln 
                965                 970                 975     


Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro 
            980                 985                 990         


Gly Phe Ala Glu Leu Ala Ala Pro  Leu Tyr Pro Leu Thr  Arg Pro Gly 
        995                 1000                 1005             


Thr Leu  Phe Gln Trp Gly Thr  Glu Gln Gln Leu Ala  Phe Glu Asn 
    1010                 1015                 1020             


Ile Arg  Lys Ala Leu Leu Ser  Ser Pro Ala Leu Gly  Leu Pro Asp 
    1025                 1030                 1035             


Ile Thr  Lys Pro Phe Glu Leu  Phe Ile Asp Glu Asn  Ser Gly Phe 
    1040                 1045                 1050             


Ala Lys  Gly Val Leu Val Gln  Lys Leu Gly Pro Trp  Lys Arg Pro 
    1055                 1060                 1065             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Thr Val Ala  Ser Gly Trp 
    1070                 1075                 1080             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Ile  Leu Val Lys 
    1085                 1090                 1095             


Asp Ala  Gly Lys Leu Thr Leu  Gly Gln Pro Leu Thr  Ile Leu Thr 
    1100                 1105                 1110             


Ser His  Pro Val Glu Ala Leu  Val Arg Gln Pro Pro  Asn Lys Trp 
    1115                 1120                 1125             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Met  Leu Leu Asp 
    1130                 1135                 1140             


Ala Glu  Arg Val His Phe Gly  Pro Thr Val Ser Leu  Asn Pro Ala 
    1145                 1150                 1155             


Thr Leu  Leu Pro Leu Pro Ser  Gly Lys Pro Pro Arg  Leu Ser Pro 
    1160                 1165                 1170             


Asp Leu  Ala Glu Thr Met Ala  Gln Thr Asp Leu Thr  Asp Gln Pro 
    1175                 1180                 1185             


Leu Pro  Asp Ala Asp Leu Thr  Trp Tyr Thr Asn Gly  Ser Ser Phe 
    1190                 1195                 1200             


Ile Arg  Asn Gly Glu Arg Lys  Ala Gly Ala Ala Val  Thr Thr Glu 
    1205                 1210                 1215             


Ser Glu  Val Ile Trp Ala Ala  Ser Leu Pro Pro Gly  Thr Ser Ala 
    1220                 1225                 1230             


Gln Arg  Ala Glu Leu Ile Ala  Leu Thr Gln Ala Leu  Lys Met Ala 
    1235                 1240                 1245             


Lys Gly  Lys Lys Leu Thr Val  Tyr Thr Asp Ser Arg  Tyr Ala Phe 
    1250                 1255                 1260             


Ala Thr  Ala His Val His Gly  Glu Ile Tyr Arg Arg  Arg Gly Leu 
    1265                 1270                 1275             


Leu Thr  Ser Glu Gly Lys Glu  Ile Lys Asn Lys Asn  Glu Ile Leu 
    1280                 1285                 1290             


Ala Leu  Leu Glu Ala Leu Phe  Leu Pro Lys Arg Leu  Ser Ile Ile 
    1295                 1300                 1305             


His Cys  Pro Gly His Gln Lys  Gly Asp Ser Pro Gln  Ala Lys Gly 
    1310                 1315                 1320             


Asn Arg  Leu Ala Asp Asp Thr  Ala Lys Lys Ala Ala  Thr Glu Thr 
    1325                 1330                 1335             


Gln Ser  Ser Leu Thr Ile Leu  Ser Ser Ser Ala Ser  
    1340                 1345                 1350 


<210>  16
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Glu Phe Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu 
1               5                   10                  15      


Ser Thr Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Met Ala His Cys Gln Ala Pro 
        35                  40                  45              


Val Leu Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln 
    50                  55                  60                  


Tyr Pro Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg 
65                  70                  75                  80  


Arg Met Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Lys Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His 
    130                 135                 140                 


Pro Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Ile Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly 
225                 230                 235                 240 


Thr Lys Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr 
            260                 265                 270         


Ser Leu Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala 
        275                 280                 285             


Ile Leu Ser Ile Pro Val Pro Lys Asn Pro Arg Gln Val Arg Glu Phe 
    290                 295                 300                 


Leu Gly Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Leu Ala Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln 
                325                 330                 335     


Trp Gly Thr Glu Gln Gln Leu Ala Phe Glu Asn Ile Arg Lys Ala Leu 
            340                 345                 350         


Leu Ser Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Thr Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro 
            420                 425                 430         


Leu Thr Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro 
        435                 440                 445             


Pro Asn Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met 
    450                 455                 460                 


Leu Leu Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Ser Gly Lys Pro Pro Arg Leu Ser 
                485                 490                 495     


Pro Asp Leu Ala Glu Thr Met Ala Gln Thr Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Ser Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Lys Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr Gln Ser Ser Leu Thr Ile Leu Ser Ser Ser 
            660                 665                 670         


Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu 
        675                 680                 685             


His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu 
    690                 695                 700                 


Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala 
705                 710                 715                 720 


Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro 
                725                 730                 735     


Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile 
            740                 745                 750         


Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys 
        755                 760                 765             


Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr 
    770                 775                 780                 


Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val 
785                 790                 795                 800 


Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly 
                805                 810                 815     


Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            820                 825                 830         


Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe 
        835                 840                 845             


Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr 
    850                 855                 860                 


Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala 
865                 870                 875                 880 


Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile 
                885                 890                 895     


Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu 
            900                 905                 910         


Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu 
        915                 920                 925             


Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val 
    930                 935                 940                 


Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu 
945                 950                 955                 960 


Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg 
                965                 970                 975     


Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile 
            980                 985                 990         


Pro Gly Phe Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Thr 
        995                 1000                 1005             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1010                 1015                 1020             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1025                 1030                 1035             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1055                 1060                 1065             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1070                 1075                 1080             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1085                 1090                 1095             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1100                 1105                 1110             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1115                 1120                 1125             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1130                 1135                 1140             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1145                 1150                 1155             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1160                 1165                 1170             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1175                 1180                 1185             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asn Gly 
    1190                 1195                 1200             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1205                 1210                 1215             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1220                 1225                 1230             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1235                 1240                 1245             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1250                 1255                 1260             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1265                 1270                 1275             


Arg Gly  Leu Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1280                 1285                 1290             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1295                 1300                 1305             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1310                 1315                 1320             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1325                 1330                 1335             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  17
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Gln Leu Glu Glu 
        675                 680                 685             


Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr Gln Lys Gln Glu Met Asp 
    690                 695                 700                 


Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met 
705                 710                 715                 720 


Gly Met Ala His Cys Gln Ala Pro Val Leu Ile Gln Leu Lys Ala Thr 
                725                 730                 735     


Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro Met Pro His Glu Ala Tyr 
            740                 745                 750         


Gln Gly Ile Lys Pro His Ile Arg Arg Met Leu Asp Gln Gly Ile Leu 
        755                 760                 765             


Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys 
    770                 775                 780                 


Pro Gly Thr Lys Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn 
785                 790                 795                 800 


Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu 
                805                 810                 815     


Leu Ser Thr Leu Pro Pro Ser His Pro Trp Tyr Thr Val Leu Asp Leu 
            820                 825                 830         


Lys Asp Ala Phe Phe Cys Leu Arg Leu His Ser Glu Ser Gln Leu Leu 
        835                 840                 845             


Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile Gly Leu Ser Gly Gln Leu 
    850                 855                 860                 


Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe 
865                 870                 875                 880 


Asp Glu Ala Leu His Ser Asp Leu Ala Asp Phe Arg Val Arg Tyr Pro 
                885                 890                 895     


Ala Leu Val Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Ala 
            900                 905                 910         


Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys Ala Leu Leu Glu Thr Leu 
        915                 920                 925             


Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Leu 
    930                 935                 940                 


Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu Lys Asp Gly Gln Arg Trp 
945                 950                 955                 960 


Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu Ser Ile Pro Val Pro Lys 
                965                 970                 975     


Asn Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Tyr Cys Arg 
            980                 985                 990         


Leu Trp Ile Pro Gly Phe Ala Glu  Leu Ala Ala Pro Leu  Tyr Pro Leu 
        995                 1000                 1005             


Thr Arg  Pro Gly Thr Leu Phe  Gln Trp Gly Thr Glu  Gln Gln Leu 
    1010                 1015                 1020             


Ala Phe  Glu Asn Ile Arg Lys  Ala Leu Leu Ser Ser  Pro Ala Leu 
    1025                 1030                 1035             


Gly Leu  Pro Asp Ile Thr Lys  Pro Phe Glu Leu Phe  Ile Asp Glu 
    1040                 1045                 1050             


Asn Ser  Gly Phe Ala Lys Gly  Val Leu Val Gln Lys  Leu Gly Pro 
    1055                 1060                 1065             


Trp Lys  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Thr Val 
    1070                 1075                 1080             


Ala Ser  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1085                 1090                 1095             


Ile Leu  Val Lys Asp Ala Gly  Lys Leu Thr Leu Gly  Gln Pro Leu 
    1100                 1105                 1110             


Thr Ile  Leu Thr Ser His Pro  Val Glu Ala Leu Val  Arg Gln Pro 
    1115                 1120                 1125             


Pro Asn  Lys Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1130                 1135                 1140             


Met Leu  Leu Asp Ala Glu Arg  Val His Phe Gly Pro  Thr Val Ser 
    1145                 1150                 1155             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Ser Gly  Lys Pro Pro 
    1160                 1165                 1170             


Arg Leu  Ser Pro Asp Leu Ala  Glu Thr Met Ala Gln  Thr Asp Leu 
    1175                 1180                 1185             


Thr Asp  Gln Pro Leu Pro Asp  Ala Asp Leu Thr Trp  Tyr Thr Asn 
    1190                 1195                 1200             


Gly Ser  Ser Phe Ile Arg Asn  Gly Glu Arg Lys Ala  Gly Ala Ala 
    1205                 1210                 1215             


Val Thr  Thr Glu Ser Glu Val  Ile Trp Ala Ala Ser  Leu Pro Pro 
    1220                 1225                 1230             


Gly Thr  Ser Ala Gln Arg Ala  Glu Leu Ile Ala Leu  Thr Gln Ala 
    1235                 1240                 1245             


Leu Lys  Met Ala Lys Gly Lys  Lys Leu Thr Val Tyr  Thr Asp Ser 
    1250                 1255                 1260             


Arg Tyr  Ala Phe Ala Thr Ala  His Val His Gly Glu  Ile Tyr Arg 
    1265                 1270                 1275             


Arg Arg  Gly Leu Leu Thr Ser  Glu Gly Lys Glu Ile  Lys Asn Lys 
    1280                 1285                 1290             


Asn Glu  Ile Leu Ala Leu Leu  Glu Ala Leu Phe Leu  Pro Lys Arg 
    1295                 1300                 1305             


Leu Ser  Ile Ile His Cys Pro  Gly His Gln Lys Gly  Asp Ser Pro 
    1310                 1315                 1320             


Gln Ala  Lys Gly Asn Arg Leu  Ala Asp Asp Thr Ala  Lys Lys Ala 
    1325                 1330                 1335             


Ala Thr  Glu Thr Gln Ser Ser  Leu Thr Ile Leu Ser  Ser Ser Ala 
    1340                 1345                 1350             


Ser 
    


<210>  18
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Glu Phe Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser 
1               5                   10                  15      


Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
            20                  25                  30          


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
        35                  40                  45              


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys 
    50                  55                  60                  


Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
65                  70                  75                  80  


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
                85                  90                  95      


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
            100                 105                 110         


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
        115                 120                 125             


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
    130                 135                 140                 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
145                 150                 155                 160 


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
                165                 170                 175     


Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
            180                 185                 190         


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
        195                 200                 205             


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
    210                 215                 220                 


Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
225                 230                 235                 240 


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala 
                245                 250                 255     


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
            260                 265                 270         


Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
        275                 280                 285             


Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu 
    290                 295                 300                 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
305                 310                 315                 320 


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
                325                 330                 335     


Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala 
            340                 345                 350         


Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe 
        355                 360                 365             


Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr 
    370                 375                 380                 


Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys 
385                 390                 395                 400 


Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala 
                405                 410                 415     


Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln 
            420                 425                 430         


Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln 
        435                 440                 445             


Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala 
    450                 455                 460                 


Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu 
465                 470                 475                 480 


Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn 
                485                 490                 495     


Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser 
        515                 520                 525             


Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr 
    530                 535                 540                 


Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu 
                565                 570                 575     


Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser 
        595                 600                 605             


Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
    610                 615                 620                 


Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His 
625                 630                 635                 640 


Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln 
                645                 650                 655     


Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu 
            660                 665                 670         


Leu Ser Ser Ser Ala Ser Lys Leu Glu Phe Thr Leu Asn Ile Glu Asp 
        675                 680                 685             


Glu His Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly 
    690                 695                 700                 


Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
705                 710                 715                 720 


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
                725                 730                 735     


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala 
            740                 745                 750         


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
        755                 760                 765             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    770                 775                 780                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
785                 790                 795                 800 


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                805                 810                 815     


Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
            820                 825                 830         


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
        835                 840                 845             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
    850                 855                 860                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
865                 870                 875                 880 


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
                885                 890                 895     


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
            900                 905                 910         


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
        915                 920                 925             


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
    930                 935                 940                 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
945                 950                 955                 960 


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
                965                 970                 975     


Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            980                 985                 990         


Arg Leu Trp Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
        995                 1000                 1005             


Leu Thr  Lys Thr Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1010                 1015                 1020             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1025                 1030                 1035             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1040                 1045                 1050             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1055                 1060                 1065             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1070                 1075                 1080             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1085                 1090                 1095             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1100                 1105                 1110             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1115                 1120                 1125             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1130                 1135                 1140             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1145                 1150                 1155             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1160                 1165                 1170             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1175                 1180                 1185             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1190                 1195                 1200             


Tyr Thr  Asn Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1205                 1210                 1215             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1220                 1225                 1230             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1235                 1240                 1245             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1250                 1255                 1260             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1265                 1270                 1275             


Ile Tyr  Arg Arg Arg Gly Leu  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1280                 1285                 1290             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1295                 1300                 1305             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1310                 1315                 1320             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1325                 1330                 1335             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1340                 1345                 1350             


Ser Ser  Ser Ala Ser 
    1355             


