                         SEQUENCE LISTING

<110>  The General Hospital Corporation
 
<120>  COMPOSITIONS AND METHODS FOR TREATING DRUG-TOLERANT GLIOBLASTOMA

<130>  364950.1059WO1(00095)

<140>  PCT/US16/24083
<141>  2016-03-24

<150>  US62/266,544
<151>  2015-12-11

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Ala Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His 
        35                  40                  45              


Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser 
    50                  55                  60                  


Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly 
                85                  90                  95      


Leu Asn Asn Val Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr 
            100                 105                 110         


Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro 
        115                 120                 125             


Ala Asn Asn Glu Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile 
    130                 135                 140                 


Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr 
                165                 170                 175     


Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu Thr 
            180                 185                 190         


Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys 
        195                 200                 205             


Lys Met Trp Lys Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala 
    210                 215                 220                 


Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser 
225                 230                 235                 240 


Trp Asp Phe Gly Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala 
            260                 265                 270         


Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly 
        275                 280                 285             


Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln 
    290                 295                 300                 


Thr Pro Gln Pro His His His His His His His Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Pro Val Ser Ala Gly Thr Ile Phe 
                325             


<210>  2
<211>  2308
<212>  DNA
<213>  Homo sapiens

<400>  2
aagaggatgc gaccagaggc agctgtcccg agcagcgcac ggtgatcgcc tcccccggag       60

gaggaggcgc ctagacggtt gcctcctttc ttgtttcccc accaccaccc ccgtaattac      120

attggctgct ggaggggacc gggagagaca gaggaggcgc ctggcttccc ccgcacgccc      180

gccacctctg ctctttcccg tctcgggcca ggatgactgg agtctttgac agtctagtgg      240

ctgatatgca ctcgacccag atcgccgcct ccagcacgta ccaccagcac cagcagcccc      300

cgagcggcgg cggcgccggc ccgggtggca acagcagcag cagcagcagc ctccacaagc      360

cccaggagtc gcccaccctt ccggtgtcca ccgccaccga cagcagctac tacaccaacc      420

agcagcaccc ggcgggcggc ggcggcggcg ggggctcgcc ctacgcgcac atgggttcct      480

accagtacca agccagcggc ctcaacaacg tcccttactc cgccaagagc agctatgacc      540

tgggctacac cgccgcctac acctcctacg ctccctatgg aaccagttcg tccccagcca      600

acaacgagcc tgagaaggag gaccttgagc ctgaaattcg gatagtgaac gggaagccaa      660

agaaagtccg gaaaccccgc accatctact ccagtttcca gctggcggct cttcagcggc      720

gtttccaaaa gactcaatac ttggccttgc cggagcgagc cgagctggcg gcctctctgg      780

gcctcaccca gactcaggtc aaaatctggt tccagaaccg ccggtccaag ttcaagaaga      840

tgtggaaaag tggtgagatc ccctcggagc agcaccctgg ggccagcgct tctccacctt      900

gtgcttcgcc gccagtctca gcgccggcct cctgggactt tggtgtgccg cagcggatgg      960

cgggcggcgg tggtccgggc agtggcggca gcggcgccgg cagctcgggc tccagcccga     1020

gcagcgcggc ctcggctttt ctgggcaact acccctggta ccaccagacc tcgggatccg     1080

cctcacacct gcaggccacg gcgccgctgc tgcaccccac tcagaccccg cagccgcatc     1140

accaccacca ccatcacggc ggcgggggcg ccccggtgag cgcggggacg attttctaac     1200

cccagggaga actcgccaga gactgagagc agagaccact tatcctcatt gcttaccccg     1260

agccggggtt ccctcctccc ggcccgctgc cgccacccac ctctcctgca ggctgcgacc     1320

tgcagtggcc cgtctcaggc cctgctcact cccggggcca ccaaacgggc ccctctctcg     1380

ggggaaccgg acagcagctt ggcaaaggcc tccctaaaag gccgcatttc tgacctgagc     1440

cccgggtctc ggctgtttcg agccccgcct cggacttgcc ttccctcccc tccgggtgag     1500

cctgtctggc gccttcctcg ccccgggctg agagctgggt cccgggagat ggaagcctcc     1560

caggcgcgcg aggcttcccg ggcgctctga ggcttctttc tcctcgcccg ctcccctggg     1620

ctcagctcgg acgctgcagt tattgacctc ccggtcccgc ctgcccgccc tcccccacgt     1680

ggccccttga cccgggcggc cccgccgctt ctttccttcc tgcagttccc agccctcgga     1740

gcccccatcc cttatcttac ccccaccgcg ctcccccagg agcgctccct cagctctctc     1800

ctcatccatc accagtggag tttttttatt tgttattttt ttaaaagttt aggtgccttt     1860

gcggatgacc tcattttgac gttgaaaaaa tgatttttta atatgtgaac actgcaaaaa     1920

tgtgtttaaa ttatcttttt taaaacctat tcaggattat tagcctggac ttggacacag     1980

agtttgtaaa taaaggtgtc tgtgcagatt ttcccactga tttatttgta taaaaatact     2040

catcttttca gacttttttg taaaccccca gttgtgaaaa ctgcagttta gcagtgacct     2100

cagcaacccc tcctttttat tttttccttt aaaaacattt cagttaaatt aagctactga     2160

tttggatttg ttttatcgta tcctaaagtc tttgttgttg aaatgaaagg tattttgggg     2220

ttatttatta tgaaaacaac atgctcttaa tgttgatttt acaatatgaa gagattattt     2280

aaataaatta ttgttttcat tggaaaaa                                        2308


<210>  3
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Glu Ala Phe Cys Ala Thr Trp Lys Leu Thr Asn Ser Gln Asn 
1               5                   10                  15      


Phe Asp Glu Tyr Met Lys Ala Leu Gly Val Gly Phe Ala Thr Arg Gln 
            20                  25                  30          


Val Gly Asn Val Thr Lys Pro Thr Val Ile Ile Ser Gln Glu Gly Asp 
        35                  40                  45              


Lys Val Val Ile Arg Thr Leu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Gln Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Asn 
65                  70                  75                  80  


Cys Lys Ser Val Val Ser Leu Asp Gly Asp Lys Leu Val His Ile Gln 
                85                  90                  95      


Lys Trp Asp Gly Lys Glu Thr Asn Phe Val Arg Glu Ile Lys Asp Gly 
            100                 105                 110         


Lys Met Val Met Thr Leu Thr Phe Gly Asp Val Val Ala Val Arg His 
        115                 120                 125             


Tyr Glu Lys Ala 
    130         


<210>  4
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  4
tttctcaggc ataagggctg tagtgtgagg attgggagga actcgaccta ctccgctaac       60

ccagtggcct gagccaatca caaagaggat tggagcctca ctcgagcgct ccttcccttc      120

tcctctctct gtgacagcct cttggaaaga gggacactgg aggggtgtgt ttgcaattta      180

aatcactgga tttttgccca ccctctttcc aaataagaag gcaggagctg cttgctgagg      240

tgtaaagggt cttctgagct gcagtggcaa ttagaccaga agatccccgc tcctgtctct      300

aaagagggga aagggcaagg atggtggagg ctttctgtgc tacctggaag ctgaccaaca      360

gtcagaactt tgatgagtac atgaaggctc taggcgtggg ctttgccact aggcaggtgg      420

gaaatgtgac caaaccaacg gtaattatca gtcaagaagg agacaaagtg gtcatcagga      480

ctctcagcac attcaagaac acggagatta gtttccagct gggagaagag tttgatgaaa      540

ccactgcaga tgatagaaac tgtaagtctg ttgttagcct ggatggagac aaacttgttc      600

acatacagaa atgggatggc aaagaaacaa attttgtaag agaaattaag gatggcaaaa      660

tggttatgac ccttactttt ggtgatgtgg ttgctgttcg ccactatgag aaggcataaa      720

aatgttcctg gtcggggctt ggaagagctc ttcagttttt ctgtttcctc aagtctcagt      780

gctatcctat tacaacatgg ctgatcatta attagaaggt tatccttggt gtggaggtgg      840

aaaatggtga tttaaaaact tgttactcca agcaacttgc ccaattttaa tctgaaaatt      900

tatcatgttt tataatttga attaaagttt tgtccccccc cccctttttt ttataaacaa      960

gtgaatacat tttataattt cttttggaat gtaaatcaaa tttgaataaa aatcttacac     1020

gtgaaattta aaaaaaaaaa aaaaaaa                                         1047


<210>  5
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Ser Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys 
1               5                   10                  15      


Asn Arg Leu Arg Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile 
            20                  25                  30          


Asn Ser Ser Ile Glu Gln Leu Lys Leu Leu Leu Glu Gln Glu Phe Ala 
        35                  40                  45              


Arg His Gln Pro Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met 
    50                  55                  60                  


Ala Val Ser Tyr Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Lys Ser Leu His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu 
                85                  90                  95      


Gln Glu Ala Val Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln 
            100                 105                 110         


Met Lys Leu Leu Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Lys Glu Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu 
    130                 135                 140                 


Ser Ala Lys Ala Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Trp Arg Pro Trp 
                165     


<210>  6
<211>  1319
<212>  DNA
<213>  Homo sapiens

<400>  6
cgcgcttggc cttgcccgcg cccgctcgcc tcgtctcgcc cggcctcccc gcgtcgcctc       60

gtcgcctgtt ccgcgccagg catggccccc agcactgtgg ccgtggagct gctcagcccc      120

aaagagaaaa accgactgcg gaagccggtg gtggagaaga tgcgccgcga ccgcatcaac      180

agcagcatcg agcagctgaa gctgctgctg gagcaggagt tcgcgcggca ccagcccaac      240

tccaagctgg agaaggccga catcctggag atggctgtca gctacctgaa gcacagcaaa      300

gccttcgtcg ccgccgccgg ccccaagagc ctgcaccagg actacagcga aggctactcg      360

tggtgcctgc aggaggccgt gcagttcctg acgctccacg ccgccagcga cacgcagatg      420

aagctgctgt accacttcca gcggcccccg gccgcgcccg ccgcgcccgc caaggagccc      480

aaggcgccgg gcgccgcgcc cccgcccgcg ctctccgcca aggccaccgc cgccgccgcc      540

gccgcgcacc agcccgcctg cggcctctgg cggccctggt gacccggcgg gacctgcggg      600

cgcgcggccc gacgaccaga gggcgagcct gctcctctcg cctgtaggga agcgccttcc      660

cgccgtcgtc cgccccgggc ttggacgcgc ccttctccgg aaggctctgg ccccaagctg      720

gccggcccgc aggagcccca ttctcagaga atgtgtgtgc agagtccctg ccgttttagg      780

acaatcaggg cccatcttct gccaagtgtc tgaccccatg gggttgttct gtgtttgcat      840

ttaagcaagt gacttctggg aagtccccgg ccgcccgggg ttctatgata tttgtagtgc      900

cggggctcgc acactgctgc ccccagcctg tagaggactt tcttcagggc ccgtagctgc      960

tgggcgtacc cctggcaggc gggctgtgcc gcgggcacat ttgccttttg tgaaggccga     1020

actcgagctg tatcctcata ggaaacagtg atcaccccgg acgggcgtcc aggaccctga     1080

gggccatggc caaaaggctc ctgagtgtgc ctggtggtct ggctggggct cacggtgggc     1140

tgtctgggga gggtgggtgc ctccactatg atccttaaag gattcctctg tgtgggtgga     1200

tgcgtgtggg cacgactttg tactcagaaa ttgaactctc agtcacgtgg aagccacggg     1260

actgctccga agccgccata ataaaatctg attgttcagc ccccaaaaaa aaaaaaaaa      1319


<210>  7
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Val Met Glu Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu 
                85                  90                  95      


Ile Leu Gln Met Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly 
            100                 105                 110         


Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser 
        115                 120                 125             


Leu Gly Phe Arg Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile 
    130                 135                 140                 


Ile Glu Gly Leu Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser 
145                 150                 155                 160 


His Leu Asn Asn Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His 
                165                 170                 175     


Ala Gly Leu Gly His Ile Pro Trp Gly Thr Val Phe Gly His His Pro 
            180                 185                 190         


His Ile Ala His Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala 
        195                 200                 205             


Gly Thr Thr Ala Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly 
    210                 215                 220                 


Ser Ala His Pro Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser 
225                 230                 235                 240 


Leu Gly Pro Val Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro 
                245                 250                 255     


Pro Leu Leu Ser Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe 
            260                 265                 270         


Gly Ser Phe His Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro 
        275                 280                 285             


Thr Gln Ala Ala Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu 
    290                 295                 300                 


Ile Gly Ala Phe 
305             


<210>  8
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  8
ttccccactc ccccgccctc cccagggccc tgggaagggg ctcagcgtgg gaaaggatgg       60

ttgagtttta accagaggca aagcgtgagc gggatcagtg tgtgcggaac gcaagcagcc      120

gagagcggag aggcgccgct gtagttaact cctccctgcc cgccgcgccg accctcccca      180

ggaaccccca gggagccagc atgaagcgag ctcaccccga gtacagctcc tcggacagcg      240

agctggacga gaccatcgag gtggagaagg agagtgcgga cgagaatgga aacttgagtt      300

cggctctagg ttccatgtcc ccaactacat cttcccagat tttggccaga aaaagacgga      360

gaggaataat tgagaagcgc cgacgagacc ggatcaataa cagtttgtct gagctgagaa      420

ggctggtacc cagtgctttt gagaagcagg taatggagca aggatctgct aagctagaaa      480

aagccgagat cctgcagatg accgtggatc acctgaaaat gctgcatacg gcaggaggga      540

aaggttactt tgacgcgcac gcccttgcta tggactatcg gagtttggga tttcgggaat      600

gcctggcaga agttgcgcgt tatctgagca tcattgaagg actagatgcc tctgacccgc      660

ttcgagttcg actggtttcg catctcaaca actacgcttc ccagcgggaa gccgcgagcg      720

gcgcccacgc gggcctcgga cacattccct gggggaccgt cttcggacat cacccgcaca      780

tcgcgcaccc gctgttgctg ccccagaacg gccacgggaa cgcgggcacc acggcctcac      840

ccacggaacc gcaccaccag ggcaggctgg gctcggcaca tccggaggcg cctgctttgc      900

gagcgccccc tagcggcagc ctcggaccgg tgctccctgt ggtcacctcc gcctccaaac      960

tgtcgccgcc tctgctctcc tcagtggcct ccctgtcggc cttccccttc tctttcggct     1020

ccttccactt actgtctccc aatgcactga gcccttcagc acccacgcag gctgcaaacc     1080

ttggcaagcc ctatagacct tgggggacgg agatcggagc tttttaaaga actgatgtag     1140

aatgagggag gggaaagttt aaaatcccag ctgggctgga ctgttgccaa catcacctta     1200

aagtcgtcag taaaagtaaa aaggaaaaag gtacactttc agataatttt ttttttaaag     1260

actaaaggtt tgttggttta cttttatctt ttttaatgtt tttttcatca tgtcatgtat     1320

tagcagtttt taaaaactag ttgttaaatt ttgttcaaga cattaaattg aaatagtgag     1380

tataagccaa cactttgtga taggtttgta ctgtgcctaa tttactttgt aaaccagaat     1440

gattccgttt ttgcctcaaa atttggggaa tcttaacatt tagtattttt ggtctgtttt     1500

tctccttgta tagttatggt ctgtttttag aattaatttt ccaaaccact atgcttaatg     1560

ttaacatgat tctgtttgtt aatattttga cagattaagg tgttgtataa ataatattct     1620

tttgggggga ggggaactat attgaatttt atatttctga gcaaagcgtt gacaaatcag     1680

atgatcagct ttatccaaga aagaagacta gtaaattgtc tgcctcctat agcagaaagg     1740

tgaatgtaca aactgttggt ggccctgaat ccatctgacc agctgctggt atctgccagg     1800

actggcagtt ctgatttagt taggagagag ccgctgatag gttaggtctc atttggagtg     1860

ttggtggaaa ggaaactgaa ggtaattgaa tagaatacgc ctgcatttac cagccccagc     1920

aacacaaaga atttttaatc acacggatct caaattcaca aatgttaaca tggataagtg     1980

atcatggtgt gcgagtggtc aattgagtag tacagtggaa actgttaaat gcataaccta     2040

attttcctgg gactgccata ttttctttta actggaaatt tttatgtgag ttttcctttt     2100

ggtgcatgga actgtggttg ccaaggtatt taaaagggct ttcctgcctc cttctctttg     2160

atttatttaa tttgatttgg gctataaaat atcatttttc aggtttattc ttttagcagg     2220

tgtagttaaa cgacctccac tgaactgggt ttgacctctg ttgtactgat gtgttgtgac     2280

taaataaaaa agaaagaaca aagtaaaaaa aaaaaaaaaa aaaaaaaaaa a              2331


<210>  9
<211>  1453
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala 
    210                 215                 220                 


Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln 
225                 230                 235                 240 


Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val 
                245                 250                 255     


Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr 
            260                 265                 270         


Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr 
        275                 280                 285             


Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe 
    290                 295                 300                 


Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr 
305                 310                 315                 320 


Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp 
                325                 330                 335     


Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
            340                 345                 350         


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
        355                 360                 365             


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
    370                 375                 380                 


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
385                 390                 395                 400 


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
                405                 410                 415     


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
            420                 425                 430         


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Ala Cys Lys Pro His 
        435                 440                 445             


His Pro Asn Thr Glu Pro Val Leu Gly Leu Ser Gln Thr Pro Ile Ser 
    450                 455                 460                 


Gln Gln Ser Leu Pro Leu His Met Ile Pro Ser Ser Gln Val Asp Asp 
465                 470                 475                 480 


Leu Ser Ser Pro Ala Lys Arg Lys Arg Thr Ser Ser Pro Thr Lys Asn 
                485                 490                 495     


Thr Ser Asp Asn Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val 
            500                 505                 510         


Gln Gln Gln Ala His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His 
        515                 520                 525             


Leu Glu Gln Leu Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys 
    530                 535                 540                 


Leu Met Leu Glu Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His 
545                 550                 555                 560 


Gln Met Arg Pro Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro 
                565                 570                 575     


Asn Gly Pro Thr Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly 
            580                 585                 590         


Gln Gln Pro Gln Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro 
        595                 600                 605             


Gly Val Arg Pro Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe 
    610                 615                 620                 


Ser Ala Gly His Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr 
625                 630                 635                 640 


Asp Thr Ile Leu Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn 
                645                 650                 655     


Gly Asn Val Pro Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn 
            660                 665                 670         


Arg Thr Asn Leu Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu 
        675                 680                 685             


Ser Asn Ser Thr Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala 
    690                 695                 700                 


Gly Pro Asn Gly Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His 
705                 710                 715                 720 


Leu Gln Ala Ala Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr 
                725                 730                 735     


Leu Pro Ser Asn Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser 
            740                 745                 750         


Ser His Thr Ala Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys 
        755                 760                 765             


Glu Ser Lys Pro Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg 
    770                 775                 780                 


His Thr Gly Glu Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro 
785                 790                 795                 800 


Asn His Val His Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His 
                805                 810                 815     


Gly Asp Ser Lys Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu 
            820                 825                 830         


Ser Ala Leu Leu Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr 
        835                 840                 845             


Cys Asp Lys Val Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp 
    850                 855                 860                 


Asn Ser Val Ala Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro 
865                 870                 875                 880 


Ser Pro Lys Ser Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu 
                885                 890                 895     


Asn Ser Pro His Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu 
            900                 905                 910         


Glu Ser Gln Ser Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys 
        915                 920                 925             


Pro Ser Pro Gln Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser 
    930                 935                 940                 


Ser Ala Glu Val Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu 
945                 950                 955                 960 


Ser Asn Ser Ser Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro 
                965                 970                 975     


Ser Ser Pro Tyr Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr 
            980                 985                 990         


Pro Ser Ile Tyr Leu Glu Asn Lys  Arg Asp Ala Phe Phe  Pro Pro Leu 
        995                 1000                 1005             


His Gln  Phe Cys Thr Asn Pro  Asn Asn Pro Val Thr  Val Ile Arg 
    1010                 1015                 1020             


Gly Leu  Ala Gly Ala Leu Lys  Leu Asp Leu Gly Leu  Phe Ser Thr 
    1025                 1030                 1035             


Lys Thr  Leu Val Glu Ala Asn  Asn Glu His Met Val  Glu Val Arg 
    1040                 1045                 1050             


Thr Gln  Leu Leu Gln Pro Ala  Asp Glu Asn Trp Asp  Pro Thr Gly 
    1055                 1060                 1065             


Thr Lys  Lys Ile Trp His Cys  Glu Ser Asn Arg Ser  His Thr Thr 
    1070                 1075                 1080             


Ile Ala  Lys Tyr Ala Gln Tyr  Gln Ala Ser Ser Phe  Gln Glu Ser 
    1085                 1090                 1095             


Leu Arg  Glu Glu Asn Glu Lys  Arg Ser His His Lys  Asp His Ser 
    1100                 1105                 1110             


Asp Ser  Glu Ser Thr Ser Ser  Asp Asn Ser Gly Arg  Arg Arg Lys 
    1115                 1120                 1125             


Gly Pro  Phe Lys Thr Ile Lys  Phe Gly Thr Asn Ile  Asp Leu Ser 
    1130                 1135                 1140             


Asp Asp  Lys Lys Trp Lys Leu  Gln Leu His Glu Leu  Thr Lys Leu 
    1145                 1150                 1155             


Pro Ala  Phe Val Arg Val Val  Ser Ala Gly Asn Leu  Leu Ser His 
    1160                 1165                 1170             


Val Gly  His Thr Ile Leu Gly  Met Asn Thr Val Gln  Leu Tyr Met 
    1175                 1180                 1185             


Lys Val  Pro Gly Ser Arg Thr  Pro Gly His Gln Glu  Asn Asn Asn 
    1190                 1195                 1200             


Phe Cys  Ser Val Asn Ile Asn  Ile Gly Pro Gly Asp  Cys Glu Trp 
    1205                 1210                 1215             


Phe Val  Val Pro Glu Gly Tyr  Trp Gly Val Leu Asn  Asp Phe Cys 
    1220                 1225                 1230             


Glu Lys  Asn Asn Leu Asn Phe  Leu Met Gly Ser Trp  Trp Pro Asn 
    1235                 1240                 1245             


Leu Glu  Asp Leu Tyr Glu Ala  Asn Val Pro Val Tyr  Arg Phe Ile 
    1250                 1255                 1260             


Gln Arg  Pro Gly Asp Leu Val  Trp Ile Asn Ala Gly  Thr Val His 
    1265                 1270                 1275             


Trp Val  Gln Ala Ile Gly Trp  Cys Asn Asn Ile Ala  Trp Asn Val 
    1280                 1285                 1290             


Gly Pro  Leu Thr Ala Cys Gln  Tyr Lys Leu Ala Val  Glu Arg Tyr 
    1295                 1300                 1305             


Glu Trp  Asn Lys Leu Gln Ser  Val Lys Ser Ile Val  Pro Met Val 
    1310                 1315                 1320             


His Leu  Ser Trp Asn Met Ala  Arg Asn Ile Lys Val  Ser Asp Pro 
    1325                 1330                 1335             


Lys Leu  Phe Glu Met Ile Lys  Tyr Cys Leu Leu Arg  Thr Leu Lys 
    1340                 1345                 1350             


Gln Cys  Gln Thr Leu Arg Glu  Ala Leu Ile Ala Ala  Gly Lys Glu 
    1355                 1360                 1365             


Ile Ile  Trp His Gly Arg Thr  Lys Glu Glu Pro Ala  His Tyr Cys 
    1370                 1375                 1380             


Ser Ile  Cys Glu Val Glu Val  Phe Asp Leu Leu Phe  Val Thr Asn 
    1385                 1390                 1395             


Glu Ser  Asn Ser Arg Lys Thr  Tyr Ile Val His Cys  Gln Asp Cys 
    1400                 1405                 1410             


Ala Arg  Lys Thr Ser Gly Asn  Leu Glu Asn Phe Val  Val Leu Glu 
    1415                 1420                 1425             


Gln Tyr  Lys Met Glu Asp Leu  Met Gln Val Tyr Asp  Gln Phe Thr 
    1430                 1435                 1440             


Leu Ala  Pro Pro Leu Pro Ser  Ala Ser Ser 
    1445                 1450             


<210>  10
<211>  5941
<212>  DNA
<213>  Homo sapiens

<400>  10
gtgtgacaca attacaacaa ctttgtgctg gtgccgggga agtttgtgtc tccaacgaat       60

cccctcagtg ctccccagcc ccgcgcgctc cggccgttcc cgccgtcccc gcctgtggct      120

gccccctgcc caaccccgcg atgtgaccct acagccgaaa gccgccgctg ccgacccggg      180

ggctccgcag cccctgccgc cgccgccgcc gccttcaccg ccgccgcgtt gggatttttc      240

gtcgccgccg cccgcggcgg aggaggaggc ggcgataaag ttggtgtgct ggtcccgcgc      300

gcagattggg ggcgtcactg cgggccccgg tccgaggggg ggtgtcggcg ttggagttgt      360

gaattcgctg cgtttccatg aaatcctgcg gagtgtcgct cgctaccgcc gccgctgccg      420

ccgccgcttt cggtgatgag gaaaagaaaa tggcggcggg aaaagcgagc ggcgagagcg      480

aggaggcgtc ccccagcctg acagccgagg agagggaggc gctcggcgga ctggacagcc      540

gcctctttgg gttcgtgaga tttcatgaag atggcgccag gacgaaggcc ctactgggca      600

aggctgttcg ctgctatgaa tctctaatct taaaagctga aggaaaagtg gagtctgatt      660

tcttttgtca attaggtcac ttcaacctct tattggaaga ttatccaaaa gcattatctg      720

cataccagag gtactacagt ttacagtctg actactggaa gaatgctgcc tttttatatg      780

gtcttggttt ggtctacttc cattataatg catttcagtg ggcaattaaa gcatttcagg      840

aggtgcttta tgttgatccc agcttttgtc gagccaagga aattcattta cgacttgggc      900

ttatgttcaa agtgaacaca gactatgagt ctagtttaaa gcattttcag ttagctttgg      960

ttgactgtaa tccctgcact ttgtccaatg ctgaaattca atttcacatt gcccacttat     1020

atgaaaccca gaggaaatat cattctgcaa aagaagctta tgaacaactt ttgcagacag     1080

agaatctttc tgcacaagta aaagcaactg tcttacaaca gttaggttgg atgcatcaca     1140

ctgtagatct cctgggagat aaagccacca aggaaagcta tgctattcag tatctccaaa     1200

agtccttgga agcagatcct aattctggcc agtcctggta tttcctcgga aggtgctatt     1260

caagtattgg gaaagttcag gatgccttta tatcttacag gcagtctatt gataaatcag     1320

aagcaagtgc agatacatgg tgttcaatag gtgtgctata tcagcagcaa aatcagccca     1380

tggatgcttt acaggcctat atttgtgctg tacaattgga ccatggccat gctgcagcct     1440

ggatggacct aggcactctc tatgaatcct gcaaccagcc tcaggatgcc attaaatgct     1500

acttaaatgc aactagaagc aaaagttgta gtaatacctc tgcacttgca gcacgaatta     1560

agtatttaca ggctcagttg tgtaaccttc cacaaggtag tctacagaat aaaactaaat     1620

tacttcctag tattgaggag gcgtggagcc taccaattcc cgcagagctt acctccaggc     1680

agggtgccat gaacacagca cagcaggcat gtaaacctca tcatccaaat actgaacctg     1740

tattaggcct cagtcaaaca ccaatttcac agcaatcctt gccactacac atgattcctt     1800

ctagccaagt agatgacctg tccagtcctg ccaagaggaa aagaacatct agtccaacaa     1860

agaatacttc tgacaattgg agtggtggac atgctgtgtc acatcctcca gtacagcaac     1920

aagctcattc atggtgtttg acaccacaga aattacagca tttggaacag ctccgcgcaa     1980

atagaaataa tttaaatcca gcacagaaac tgatgctgga acagctggaa agtcagtttg     2040

tcttaatgca acaacaccaa atgagaccaa caggagttgc acaggtacga tctactggaa     2100

ttcctaatgg gccaacagct gactcatcac tgcctacaaa ctcagtctct ggccagcagc     2160

cacagcttgc tctgaccaga gtgcctagcg tctctcagcc tggagtccgt cctgcctgcc     2220

ctgggcagcc tttggccaat ggaccctttt ctgcaggcca tgttccctgt agcacatcaa     2280

gaacgctggg aagtacagac actattttga taggcaataa tcatataaca ggaagtggaa     2340

gtaatggaaa cgtgccttac ctgcagcgaa acgcactcac tctacctcat aaccgcacaa     2400

acctgaccag cagcgcagag gagccgtgga aaaaccaact atctaactcc actcaggggc     2460

ttcacaaagg tcagagttca cattcggcag gtcctaatgg tgaacgacct ctctcttcca     2520

ctgggccttc ccagcatctc caggcagctg gctctggtat tcagaatcag aacggacatc     2580

ccaccctgcc tagcaattca gtaacacagg gggctgctct caatcacctc tcctctcaca     2640

ctgctacctc aggtggacaa caaggcatta ccttaaccaa agagagcaag ccttcaggaa     2700

acatattgac ggtgcctgaa acaagcaggc acactggaga gacacctaac agcactgcca     2760

gtgtcgaggg acttcctaat catgtccatc agatgacggc agatgctgtt tgcagtccta     2820

gccatggaga ttctaagtca ccaggtttac taagttcaga caatcctcag ctctctgcct     2880

tgttgatggg aaaagccaat aacaatgtgg gtactggaac ctgtgacaaa gtcaataaca     2940

tccacccagc tgttcataca aagactgata actctgttgc ctcttcacca tcttcagcca     3000

tttcaacagc aacaccttct ccaaaatcca ctgagcagac aaccacaaac agtgttacca     3060

gccttaacag ccctcacagt gggctacaca caattaatgg agaagggatg gaagaatctc     3120

agagccccat gaaaacagat ctgcttctgg ttaaccacaa acctagtcca cagatcatac     3180

catcaatgtc tgtgtccata taccccagct cagcagaagt tctgaaggca tgcaggaatc     3240

taggtaaaaa tggcttatct aacagtagca ttttgttgga taaatgtcca cctccaagac     3300

caccatcttc accataccct cccttgccaa aggacaagtt gaatccacct acacctagta     3360

tttacttgga aaataaacgt gatgctttct ttcctccatt acatcaattt tgtacaaatc     3420

cgaacaaccc tgttacagta atacgtggcc ttgctggagc tcttaagtta gacctgggac     3480

ttttctctac taaaactttg gtggaagcta acaatgaaca tatggtagaa gtgaggacac     3540

agttgttgca gccagcagat gaaaactggg atcccactgg aacaaagaaa atctggcatt     3600

gtgaaagtaa tagatctcat actacaattg ctaaatatgc acagtaccag gcctcctcat     3660

tccaggaatc attgagagaa gaaaatgaaa aaagaagtca tcataaagac cactcagata     3720

gtgaatctac atcgtcagat aattctggga ggaggaggaa aggacccttt aaaaccataa     3780

agtttgggac caatattgac ctatctgatg acaaaaagtg gaagttgcag ctacatgagc     3840

tgactaaact tcctgctttt gtgcgtgtcg tatcagcagg aaatcttcta agccatgttg     3900

gtcataccat attgggcatg aacacagttc aactatacat gaaagttcca gggagcagaa     3960

caccaggtca tcaggaaaat aacaacttct gttcagttaa cataaatatt ggcccaggtg     4020

actgtgaatg gtttgttgtt cctgaaggtt actggggtgt tctgaatgac ttctgtgaaa     4080

aaaataattt gaatttccta atgggttctt ggtggcccaa tcttgaagat ctttatgaag     4140

caaatgttcc agtgtatagg tttattcagc gacctggaga tttggtctgg ataaatgcag     4200

gcactgttca ttgggttcag gctattggct ggtgcaacaa cattgcttgg aatgttggtc     4260

cacttacagc ctgccagtat aaattggcag tggaacggta cgaatggaac aaattgcaaa     4320

gtgtgaagtc aatagtaccc atggttcatc tttcctggaa tatggcacga aatatcaagg     4380

tctcagatcc aaagcttttt gaaatgatta agtattgtct tctaagaact ctgaagcaat     4440

gtcagacatt gagggaagct ctcattgctg caggaaaaga gattatatgg catgggcgga     4500

caaaagaaga accagctcat tactgtagca tttgtgaagt ggaggttttt gatctgcttt     4560

ttgtcactaa tgagagtaat tcacgaaaga cctacatagt acattgccaa gattgtgcac     4620

gaaaaacaag cggaaacttg gaaaactttg tggtgctaga acagtacaaa atggaggacc     4680

tgatgcaagt ctatgaccaa tttacattag ctcctccatt accatccgcc tcatcttgat     4740

attgttccat ggacattaaa tgagaccttt tctgctattc aggaaataac ccagttctgc     4800

accactggtt tttgtagcta tctcgtaagg ctgctggctg aaaactgtgt ctatgcaacc     4860

ttccaagtgc ggagtgtcaa ccaactggac gggagagagt actgctccta ctccaggact     4920

ctcacaaagc tgatgagctg tacttcagaa aaaaataata atttccatgt tttgtatata     4980

tctgacaaaa ctggcaacat cttacagact actgacttga agacaacctc ttttatattt     5040

ctctatttct gggctgatga atttgttttc atctgtcttt tcccccttca gaattttcct     5100

tggaaaaaaa atactagcct agctggtcat ttctttgtaa ggtagttagc aattttaagt     5160

ctttctttgg tcaacttttt tttaatgtga aaagttaggt aagacacttt tttactgctt     5220

ttatgttttt ctgtcttgtt ttgagaccat gatggttaca cttttggttc ctaaataaaa     5280

tttaaaaaat taacagccaa gtcacaaagg taatggattg cacatagact aaggaataaa     5340

cttcagattt gtgatttttg tttctaatct tgatgtaaat ttacactatt tataaataca     5400

tatttattgc ttgaaaatat ttgtgaatgg aatgctgtta ttttttccag atttacctgc     5460

cattgaaatt ttaaggagtt ctgtaatttc aaacactact cctattacat tttctatgtg     5520

taaataaaac tgcttagcat tgtacagaaa cttttattaa aattgtttaa tgtttaaaga     5580

gttttctatt gtttgagttt taaaaaagac tttatgtaca gtgcccagtt tttgttcatt     5640

tttgaaatct gattatatat attttatata tacttatgta tgtatatata atatatatag     5700

aaatctggat atatatgtat aaatctttag aacttaaatt tttctcgttt taagtttcac     5760

atctatggta gatttttgag gtgtctactg taaagtattg cttacaaaaa gtatgattat     5820

ttttaaagaa atatatatgg tatgtatcct caagacctaa aatgtcagac tggtttattg     5880

ttaagttgca attactgcaa tgacagacca ataaacaatt gctgccaaaa tgtagtataa     5940

a                                                                     5941


<210>  11
<211>  1682
<212>  PRT
<213>  Homo sapiens

<400>  11

Met His Arg Ala Val Asp Pro Pro Gly Ala Arg Ala Ala Arg Glu Ala 
1               5                   10                  15      


Phe Ala Leu Gly Gly Leu Ser Cys Ala Gly Ala Trp Ser Ser Cys Pro 
            20                  25                  30          


Pro His Pro Pro Pro Arg Ser Ala Trp Leu Pro Gly Gly Arg Cys Ser 
        35                  40                  45              


Ala Ser Ile Gly Gln Pro Pro Leu Pro Ala Pro Leu Pro Pro Ser His 
    50                  55                  60                  


Gly Ser Ser Ser Gly His Pro Ser Lys Pro Tyr Tyr Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Thr Pro Arg Pro Leu His Gly Lys Leu Glu Ser Leu His Gly Cys 
                85                  90                  95      


Val Gln Ala Leu Leu Arg Glu Pro Ala Gln Pro Gly Leu Trp Glu Gln 
            100                 105                 110         


Leu Gly Gln Leu Tyr Glu Ser Glu His Asp Ser Glu Glu Ala Thr Arg 
        115                 120                 125             


Cys Tyr His Ser Ala Leu Arg Tyr Gly Gly Ser Phe Ala Glu Leu Gly 
    130                 135                 140                 


Pro Arg Ile Gly Arg Leu Gln Gln Ala Gln Leu Trp Asn Phe His Thr 
145                 150                 155                 160 


Gly Ser Cys Gln His Arg Ala Lys Val Leu Pro Pro Leu Glu Gln Val 
                165                 170                 175     


Trp Asn Leu Leu His Leu Glu His Lys Arg Asn Tyr Gly Ala Lys Arg 
            180                 185                 190         


Gly Gly Pro Pro Val Lys Arg Ala Ala Glu Pro Pro Val Val Gln Pro 
        195                 200                 205             


Val Pro Pro Ala Ala Leu Ser Gly Pro Ser Gly Glu Glu Gly Leu Ser 
    210                 215                 220                 


Pro Gly Gly Lys Arg Arg Arg Gly Cys Asn Ser Glu Gln Thr Gly Leu 
225                 230                 235                 240 


Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Leu Ala Thr Ser Pro 
            260                 265                 270         


Pro Phe Gln Leu Thr Lys Pro Gly Leu Trp Ser Thr Leu His Gly Asp 
        275                 280                 285             


Ala Trp Gly Pro Glu Arg Lys Gly Ser Ala Pro Pro Glu Arg Gln Glu 
    290                 295                 300                 


Gln Arg His Ser Leu Pro His Pro Tyr Pro Tyr Pro Ala Pro Ala Tyr 
305                 310                 315                 320 


Thr Ala His Pro Pro Gly His Arg Leu Val Pro Ala Ala Pro Pro Gly 
                325                 330                 335     


Pro Gly Pro Arg Pro Pro Gly Ala Glu Ser His Gly Cys Leu Pro Ala 
            340                 345                 350         


Thr Arg Pro Pro Gly Ser Asp Leu Arg Glu Ser Arg Val Gln Arg Ser 
        355                 360                 365             


Arg Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro 
    370                 375                 380                 


Tyr Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn 
                405                 410                 415     


Pro Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val 
            420                 425                 430         


Ser His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro 
        435                 440                 445             


Phe Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly 
    450                 455                 460                 


Pro Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro 
465                 470                 475                 480 


Pro Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu 
                485                 490                 495     


Asp Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro 
            500                 505                 510         


Arg Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro 
        515                 520                 525             


Pro Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro 
    530                 535                 540                 


Thr Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser 
545                 550                 555                 560 


His Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr 
                565                 570                 575     


Leu Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln 
            580                 585                 590         


Asn Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro 
        595                 600                 605             


Ala Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg 
    610                 615                 620                 


Pro Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val 
625                 630                 635                 640 


Gly Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val 
                645                 650                 655     


Pro Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp 
            660                 665                 670         


Phe Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe 
        675                 680                 685             


Lys Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu 
    690                 695                 700                 


Ser Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala 
705                 710                 715                 720 


Pro Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe 
                725                 730                 735     


Pro Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr 
            740                 745                 750         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu 
        755                 760                 765             


Lys Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe 
    770                 775                 780                 


Pro Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro 
785                 790                 795                 800 


Ala Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr 
                805                 810                 815     


Cys Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu 
            820                 825                 830         


Pro Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu 
        835                 840                 845             


Pro Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser 
    850                 855                 860                 


Ala Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg 
865                 870                 875                 880 


Glu Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr 
                885                 890                 895     


Gln Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu 
            900                 905                 910         


Val Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val 
        915                 920                 925             


Gly Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro 
    930                 935                 940                 


Ala Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu 
945                 950                 955                 960 


Glu Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln 
                965                 970                 975     


Lys Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp 
            980                 985                 990         


Ser Val Gly Arg Arg Pro Arg Glu  Gly Arg Ala Lys Ala  Lys Ala Lys 
        995                 1000                 1005             


Val Pro  Lys Glu Lys Ser Arg  Arg Val Leu Gly Asn  Leu Asp Leu 
    1010                 1015                 1020             


Gln Ser  Glu Glu Ile Gln Gly  Arg Glu Lys Ser Arg  Pro Asp Leu 
    1025                 1030                 1035             


Gly Gly  Ala Ser Lys Ala Lys  Pro Pro Thr Ala Pro  Ala Pro Pro 
    1040                 1045                 1050             


Ser Ala  Pro Ala Pro Ser Ala  Gln Pro Thr Pro Pro  Ser Ala Ser 
    1055                 1060                 1065             


Val Pro  Gly Lys Lys Ala Arg  Glu Glu Ala Pro Gly  Pro Pro Gly 
    1070                 1075                 1080             


Val Ser  Arg Ala Asp Met Leu  Lys Leu Arg Ser Leu  Ser Glu Gly 
    1085                 1090                 1095             


Pro Pro  Lys Glu Leu Lys Ile  Arg Leu Ile Lys Val  Glu Ser Gly 
    1100                 1105                 1110             


Asp Lys  Glu Thr Phe Ile Ala  Ser Glu Val Glu Glu  Arg Arg Leu 
    1115                 1120                 1125             


Arg Met  Ala Asp Leu Thr Ile  Ser His Cys Ala Ala  Asp Val Val 
    1130                 1135                 1140             


Arg Ala  Ser Arg Asn Ala Lys  Val Lys Gly Lys Phe  Arg Glu Ser 
    1145                 1150                 1155             


Tyr Leu  Ser Pro Ala Gln Ser  Val Lys Pro Lys Ile  Asn Thr Glu 
    1160                 1165                 1170             


Glu Lys  Leu Pro Arg Glu Lys  Leu Asn Pro Pro Thr  Pro Ser Ile 
    1175                 1180                 1185             


Tyr Leu  Glu Ser Lys Arg Asp  Ala Phe Ser Pro Val  Leu Leu Gln 
    1190                 1195                 1200             


Phe Cys  Thr Asp Pro Arg Asn  Pro Ile Thr Val Ile  Arg Gly Leu 
    1205                 1210                 1215             


Ala Gly  Ser Leu Arg Leu Asn  Leu Gly Leu Phe Ser  Thr Lys Thr 
    1220                 1225                 1230             


Leu Val  Glu Ala Ser Gly Glu  His Thr Val Glu Val  Arg Thr Gln 
    1235                 1240                 1245             


Val Gln  Gln Pro Ser Asp Glu  Asn Trp Asp Leu Thr  Gly Thr Arg 
    1250                 1255                 1260             


Gln Ile  Trp Pro Cys Glu Ser  Ser Arg Ser His Thr  Thr Ile Ala 
    1265                 1270                 1275             


Lys Tyr  Ala Gln Tyr Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Gln 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ser Glu Asp  Glu Glu Ser Glu Glu  Pro Asp Ser 
    1295                 1300                 1305             


Thr Thr  Gly Thr Pro Pro Ser  Ser Ala Pro Asp Pro  Lys Asn His 
    1310                 1315                 1320             


His Ile  Ile Lys Phe Gly Thr  Asn Ile Asp Leu Ser  Asp Ala Lys 
    1325                 1330                 1335             


Arg Trp  Lys Pro Gln Leu Gln  Glu Leu Leu Lys Leu  Pro Ala Phe 
    1340                 1345                 1350             


Met Arg  Val Thr Ser Thr Gly  Asn Met Leu Ser His  Val Gly His 
    1355                 1360                 1365             


Thr Ile  Leu Gly Met Asn Thr  Val Gln Leu Tyr Met  Lys Val Pro 
    1370                 1375                 1380             


Gly Ser  Arg Thr Pro Gly His  Gln Glu Asn Asn Asn  Phe Cys Ser 
    1385                 1390                 1395             


Val Asn  Ile Asn Ile Gly Pro  Gly Asp Cys Glu Trp  Phe Ala Val 
    1400                 1405                 1410             


His Glu  His Tyr Trp Glu Thr  Ile Ser Ala Phe Cys  Asp Arg His 
    1415                 1420                 1425             


Gly Val  Asp Tyr Leu Thr Gly  Ser Trp Trp Pro Ile  Leu Asp Asp 
    1430                 1435                 1440             


Leu Tyr  Ala Ser Asn Ile Pro  Val Tyr Arg Phe Val  Gln Arg Pro 
    1445                 1450                 1455             


Gly Asp  Leu Val Trp Ile Asn  Ala Gly Thr Val His  Trp Val Gln 
    1460                 1465                 1470             


Ala Thr  Gly Trp Cys Asn Asn  Ile Ala Trp Asn Val  Gly Pro Leu 
    1475                 1480                 1485             


Thr Ala  Tyr Gln Tyr Gln Leu  Ala Leu Glu Arg Tyr  Glu Trp Asn 
    1490                 1495                 1500             


Glu Val  Lys Asn Val Lys Ser  Ile Val Pro Met Ile  His Val Ser 
    1505                 1510                 1515             


Trp Asn  Val Ala Arg Thr Val  Lys Ile Ser Asp Pro  Asp Leu Phe 
    1520                 1525                 1530             


Lys Met  Ile Lys Phe Cys Leu  Leu Gln Ser Met Lys  His Cys Gln 
    1535                 1540                 1545             


Val Gln  Arg Glu Ser Leu Val  Arg Ala Gly Lys Lys  Ile Ala Tyr 
    1550                 1555                 1560             


Gln Gly  Arg Val Lys Asp Glu  Pro Ala Tyr Tyr Cys  Asn Glu Cys 
    1565                 1570                 1575             


Asp Val  Glu Val Phe Asn Ile  Leu Phe Val Thr Ser  Glu Asn Gly 
    1580                 1585                 1590             


Ser Arg  Asn Thr Tyr Leu Val  His Cys Glu Gly Cys  Ala Arg Arg 
    1595                 1600                 1605             


Arg Ser  Ala Gly Leu Gln Gly  Val Val Val Leu Glu  Gln Tyr Arg 
    1610                 1615                 1620             


Thr Glu  Glu Leu Ala Gln Ala  Tyr Asp Ala Phe Thr  Leu Val Arg 
    1625                 1630                 1635             


Ala Arg  Arg Ala Arg Gly Gln  Arg Arg Arg Ala Leu  Gly Gln Ala 
    1640                 1645                 1650             


Ala Gly  Thr Gly Phe Gly Ser  Pro Ala Ala Pro Phe  Pro Glu Pro 
    1655                 1660                 1665             


Pro Pro  Ala Phe Ser Pro Gln  Ala Pro Ala Ser Thr  Ser Arg 
    1670                 1675                 1680         


<210>  12
<211>  6704
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcaacatgc cagccccgta gcactgccca ccccacccac tgtggtctgt tgtaccccac       60

tgctggggtg gtggttccaa tgagacaggg cacaccaaac tccatctggc tgttactgag      120

gcggagacac gggtgatgat tggctttctg gggagagagg aagtcctgtg attggccaga      180

tctctggagc ttgccgacgc ggtgtgagga cgctcccacg gaggccggaa ttggctgtga      240

aaggactgag gcagccatct gggggtagcg ggcactctta tcagagcggc tggagccgga      300

ccatcgtccc agagagctgg ggcagggggc cgtgcccaat ctccagggct cctggggcca      360

ctgctgacct ggctggatgc atcgggcagt ggaccctcca ggggcccgcg ctgcacggga      420

agcctttgcc cttgggggcc tgagctgtgc tggggcctgg agctcctgcc cgcctcatcc      480

ccctcctcgt agcgcatggc tgcctggagg cagatgctca gccagcattg ggcagccccc      540

gcttcctgct cccctacccc cttcacatgg cagtagttct gggcacccca gcaaaccata      600

ttatgctcca ggggcgccca ctccaagacc cctccatggg aagctggaat ccctgcatgg      660

ctgtgtgcag gcattgctcc gggagccagc ccagccaggg ctttgggaac agcttgggca      720

actgtacgag tcagagcacg atagtgagga ggccacacgc tgctaccaca gcgcccttcg      780

atacggagga agcttcgctg agctggggcc ccgcattggc cgactgcagc aggcccagct      840

ctggaacttt catactggct cctgccagca ccgagccaag gtcctgcccc cactggagca      900

agtgtggaac ttgctacacc ttgagcacaa acggaactat ggagccaagc ggggaggtcc      960

cccggtgaag cgagctgctg aacccccagt ggtgcagcct gtgcctcctg cagcactctc     1020

aggcccctca ggggaggagg gcctcagccc tggaggcaag cgaaggagag gctgcaactc     1080

tgaacagact ggccttcccc cagggctgcc actgcctcca ccaccattac caccaccacc     1140

accaccacca ccaccaccac caccacccct gcctggcctg gctaccagcc ccccatttca     1200

gctaaccaag ccagggctgt ggagtaccct gcatggagat gcctggggcc cagagcgcaa     1260

gggttcagca cccccagagc gccaggagca gcggcactcg ctgcctcacc catatccata     1320

cccagctcca gcgtacaccg cgcacccccc tggccaccgg ctggtcccgg ctgctccccc     1380

aggcccaggc ccccgccccc caggagcaga gagccatggc tgcctgcctg ccacccgtcc     1440

ccccggaagt gaccttagag agagcagagt tcagaggtcg cggatggact ccagcgtttc     1500

accagcagca accaccgcct gcgtgcctta cgccccttcc cggccccctg gcctccccgg     1560

caccaccacc agcagcagca gtagcagcag cagcaacact ggtctccggg gcgtggagcc     1620

gaacccaggc attcccggcg ctgaccatta ccaaactccc gcgctggagg tctctcacca     1680

tggccgcctg gggccctcgg cacacagcag tcggaaaccg ttcttggggg ctcccgctgc     1740

cactccccac ctatccctgc cacctggacc ttcctcaccc cctccacccc cctgtccccg     1800

cctcttacgc cccccaccac cccctgcctg gttgaagggt ccggcctgcc gggcagcccg     1860

agaggatgga gagatcttag aagagctctt ctttgggact gagggacccc cccgccctgc     1920

cccaccaccc ctcccccatc gcgagggctt cttggggcct ccggcctccc gcttttctgt     1980

gggcactcag gattctcaca cccctcccac tcccccaacc ccaaccacca gcagtagcaa     2040

cagcaacagt ggcagccaca gcagcagccc tgctgggcct gtgtcctttc ccccaccacc     2100

ctatctggcc agaagtatag acccccttcc ccggcctccc agcccagcac agaaccccca     2160

ggacccacct cttgtacccc tgactcttgc cctgcctcca gcccctcctt cctcctgcca     2220

ccaaaatacc tcaggaagct tcaggcgccc ggagagcccc cggcccaggg tctccttccc     2280

aaagaccccc gaggtggggc cggggccacc cccaggcccc ctgagtaaag ccccccagcc     2340

tgtgccgccc ggggttgggg agctgcctgc ccgaggccct cgactctttg attttccccc     2400

cactccgctg gaggaccagt ttgaggagcc agccgaattc aagatcctac ctgatgggct     2460

ggccaacatc atgaagatgc tggacgaatc cattcgcaag gaagaggaac agcaacaaca     2520

cgaagcaggc gtggcccccc aacccccgct gaaggagccc tttgcatctc tgcagtctcc     2580

tttccccacc gacacagccc ccaccactac tgctcctgct gtcgccgtca ccaccaccac     2640

caccaccacc accaccacca cggccaccca ggaagaggag aagaagccac caccagccct     2700

accaccacca ccgcctctag ccaagttccc tccaccctct cagccacagc caccaccacc     2760

cccacccccc agcccggcca gcctgctcaa atccttggcc tccgtgctgg agggacaaaa     2820

gtactgttat cgggggactg gagcagctgt ttccacccgg cctgggccct tgcccaccac     2880

tcagtattcc cctggccccc catcaggtgc taccgccctg ccgcccacct cagcggcccc     2940

tagcgcccag ggctccccac agccctctgc ttcctcgtca tctcagttct ctacctcagg     3000

cgggccctgg gcccgggagc gcagggcggg cgaagagcca gtcccgggcc ccatgacccc     3060

cacccaaccg cccccacccc tatctctgcc ccctgctcgc tctgagtctg aggtgctaga     3120

agagatcagc cgggcttgcg agacccttgt ggagcgggtg ggccggagtg ccactgaccc     3180

agccgaccca gtggacacag cagagccagc ggacagtggg actgagcgac tgctgccccc     3240

cgcacaggcc aaggaggagg ctggcggggt ggcggcagtg tcaggcagct gtaagcggcg     3300

acagaaggag catcagaagg agcatcggcg gcacaggcgg gcctgtaagg acagtgtggg     3360

tcgtcggccc cgtgagggca gggcaaaggc caaggccaag gtccccaaag aaaagagccg     3420

ccgggtgctg gggaacctgg acctgcagag cgaggagatc cagggtcgtg agaagtcccg     3480

gcccgatctt ggcggggcct ccaaggccaa gccacccaca gctccagccc ctccatcagc     3540

tcctgcacct tctgcccagc ccacaccccc gtcagcctct gtccctggaa agaaggctcg     3600

ggaggaagcc ccagggccac cgggtgtcag ccgggccgac atgctgaagc tgcgctcact     3660

tagtgagggg ccccccaagg agctgaagat ccggctcatc aaggtagaga gtggtgacaa     3720

ggagaccttt atcgcctctg aggtggaaga gcggcggctg cgcatggcag acctcaccat     3780

cagccactgt gctgctgacg tcgtgcgcgc cagcaggaat gccaaggtga aagggaagtt     3840

tcgagagtcc tacctttccc ctgcccagtc tgtgaaaccg aagatcaaca ctgaggagaa     3900

gctgccccgg gaaaaactca acccccctac acccagcatc tatctggaga gcaaacggga     3960

tgccttctca cctgtcctgc tgcagttctg tacagaccct cgaaatccca tcacagtgat     4020

ccggggcctg gcgggctccc tgcggctcaa cttgggcctc ttctccacca agaccctggt     4080

ggaagcgagt ggcgaacaca ccgtggaagt tcgcacccag gtgcagcagc cctcagatga     4140

gaactgggat ctgacaggca ctcggcagat ctggccttgt gagagctccc gttcccacac     4200

caccattgcc aagtacgcac agtaccaggc ctcatccttc caggagtctc tgcaggagga     4260

gaaggagagt gaggatgagg agtcagagga gccagacagc accactggaa cccctcctag     4320

cagcgcacca gacccgaaga accatcacat catcaagttt ggcaccaaca tcgacttgtc     4380

tgatgctaag cggtggaagc cccagctgca ggagctgctg aagctgcccg ccttcatgcg     4440

ggtaacatcc acgggcaaca tgctgagcca cgtgggccac accatcctgg gcatgaacac     4500

ggtgcagctg tacatgaagg tgcccggcag ccgaacgcca ggccaccagg agaataacaa     4560

cttctgctcc gtcaacatca acattggccc aggcgactgc gagtggttcg cggtgcacga     4620

gcactactgg gagaccatca gcgctttctg tgatcggcac ggcgtggact acttgacggg     4680

ttcctggtgg ccaatcctgg atgatctcta tgcatccaat attcctgtgt accgcttcgt     4740

gcagcgaccc ggagacctcg tgtggattaa tgcggggact gtgcactggg tgcaggccac     4800

cggctggtgc aacaacattg cctggaacgt ggggcccctc accgcctatc agtaccagct     4860

ggccctggaa cgatacgagt ggaatgaggt gaagaacgtc aaatccatcg tgcccatgat     4920

tcacgtgtca tggaacgtgg ctcgcacggt caaaatcagc gaccccgact tgttcaagat     4980

gatcaagttc tgcctgctgc agtccatgaa gcactgccag gtgcaacgcg agagcctggt     5040

gcgggcaggg aagaaaatcg cttaccaggg ccgtgtcaag gacgagccag cctactactg     5100

caacgagtgc gatgtggagg tgtttaacat cctgttcgtg acaagtgaga atggcagccg     5160

caacacgtac ctggtacact gcgagggctg tgcccggcgc cgcagcgcag gcctgcaggg     5220

cgtggtggtg ctggagcagt accgcactga ggagctggct caggcctacg acgccttcac     5280

gctggtgagg gcccggcggg cgcgcgggca gcggaggagg gcactggggc aggctgcagg     5340

gacgggcttc gggagcccgg ccgcgccttt ccctgagccc ccgccggctt tctcccccca     5400

ggccccagcc agcacgtcgc gatgaggccg gacgccccgc ccgcctgcct gcccgcgcaa     5460

ggcgccgcgg ggccaccagc acatgcctgg gctggaccta ggtcccgcct gtggccgaga     5520

agggggtcgg gcccagccct tccaccccat tggcagctcc cctcacttaa tttattaaga     5580

aaaacttttt tttttttttt agcaaatatg aggaaaaaag gaaaaaaaat gggagacggg     5640

ggagggggct ggcagcccct cgcccaccag cgcctcccct caccgacttt ggccttttta     5700

gcaacagaca caaggaccag gctccggcgg cggcgggggt cacatacggg ttccctcacc     5760

ctgccagccg cccgcccgcc cggcgcagat gcacgcggct cgtgtatgta catagacgtt     5820

acggcagccg aggtttttaa tgagattctt tctatgggct ttacccctcc cccggaacct     5880

ccttttttac ttccaatgct agctgtgacc cctgtacatg tctctttatt cacttggtta     5940

tgatttgtat tttttgttct tttcttgttt ttttgttttt aatttataac agtcccactc     6000

acctctattt attcattttt gggaaaaccc gacctcccac acccccaagc catcctgccc     6060

gcccctccag ggaccgcccg tcgccgggct ctccccgcgc cccagtgtgt gtccgggccc     6120

ggcccgaccg tctccacccg tccgcccgcg gctccagccg ggttctcatg gtgctcaaac     6180

ccgctcccct cccctacgtc ctgcactttc tcggaccagt ccccccactc ccgacccgac     6240

cccagcccca cctgagggtg agcaactcct gtactgtagg ggaagaagtg ggaactgaaa     6300

tggtattttg taaaaaaaat aaataaaata aaaaaattaa aggttttaaa gaaagaacta     6360

tgaggaaaag gaaccccgtc cttcccagcc ccggccaact ttaaaaaaca cagaccttca     6420

cccccacccc cttttctttt taagtgtgaa acaacccagg gccagggcct cactggggca     6480

gggacacccc ggggtgagtt tctctggggc tttattttcg ttttgttggt tgttttttct     6540

ccacgctggg gctgcggagg ggtggggggt ttacagtccc gcaccctcgc actgcactgt     6600

ctctctgccc caggggcaga ggggtcttcc caaccctacc cctattttcg gtgatttttg     6660

tgtgagaata ttaatattaa aaataaacgg agaaaaaaaa tcct                      6704


<210>  13
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  14
<211>  9322
<212>  DNA
<213>  Homo sapiens

<400>  14
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg tgaagcggcc      120

aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg gcccgcgatg ccaggacccc      180

aacccgtgcc tcagcacccc ctgcaagaac gccgggacat gccacgtggt ggaccgcaga      240

ggcgtggcag actatgcctg cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca      300

cccctggaca atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc      360

acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag      420

gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc cttcgaggcc      480

tcctacatct gccactgccc acccagcttc catggcccca cctgccggca ggatgtcaac      540

gagtgtggcc agaagcccgg gctttgccgc cacggaggca cctgccacaa cgaggtcggc      600

tcctaccgct gcgtctgccg cgccacccac actggcccca actgcgagcg gccctacgtg      660

ccctgcagcc cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc      720

cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat      780

tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa cacctacaac      840

tgccgctgcc cgccagagtg gacaggtcag tactgtaccg aggatgtgga cgagtgccag      900

ctgatgccaa atgcctgcca gaacggcggg acctgccaca acacccacgg tggctacaac      960

tgcgtgtgtg tcaacggctg gactggtgag gactgcagcg agaacattga tgactgtgcc     1020

agcgccgcct gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag     1080

tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc     1140

tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat ctgcacctgc     1200

ccctcggggt acacgggccc ggcctgcagc caggacgtgg atgagtgctc gctgggtgcc     1260

aacccctgcg agcatgcggg caagtgcatc aacacgctgg gctccttcga gtgccagtgt     1320

ctgcagggct acacgggccc ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg     1380

tgccagaacg acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc     1440

ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg     1500

cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc cacgggcttc     1560

actgggcatc tgtgccagta cgatgtggac gagtgtgcca gcaccccctg caagaatggt     1620

gccaagtgcc tggacggacc caacacttac acctgtgtgt gcacggaagg gtacacgggg     1680

acgcactgcg aggtggacat cgatgagtgc gaccccgacc cctgccacta cggctcctgc     1740

aaggacggcg tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc     1800

gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac     1860

cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa ctgcgagatc     1920

aacctggatg actgtgccag cagcccctgc gactcgggca cctgtctgga caagatcgat     1980

ggctacgagt gtgcctgtga gccgggctac acagggagca tgtgtaacat caacatcgat     2040

gagtgtgcgg gcaacccctg ccacaacggg ggcacctgcg aggacggcat caatggcttc     2100

acctgccgct gccccgaggg ctaccacgac cccacctgcc tgtctgaggt caatgagtgc     2160

aacagcaacc cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac     2220

tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac     2280

ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg cacctgccgg     2340

gagggcttca gcggtcccaa ctgccagacc aacatcaacg agtgtgcgtc caacccatgt     2400

ctgaaccagg gcacgtgtat tgacgacgtt gccgggtaca agtgcaactg cctgctgccc     2460

tacacaggtg ccacgtgtga ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac     2520

ggcggggagt gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc     2580

tggcaagggc agacctgtga ggtcgacatc aacgagtgcg ttctgagccc gtgccggcac     2640

ggcgcatcct gccagaacac ccacggcggc taccgctgcc actgccaggc cggctacagt     2700

gggcgcaact gcgagaccga catcgacgac tgccggccca acccgtgtca caacgggggc     2760

tcctgcacag acggcatcaa cacggccttc tgcgactgcc tgcccggctt ccggggcact     2820

ttctgtgagg aggacatcaa cgagtgtgcc agtgacccct gccgcaacgg ggccaactgc     2880

acggactgcg tggacagcta cacgtgcacc tgccccgcag gcttcagcgg gatccactgt     2940

gagaacaaca cgcctgactg cacagagagc tcctgcttca acggtggcac ctgcgtggac     3000

ggcatcaact cgttcacctg cctgtgtcca cccggcttca cgggcagcta ctgccagcac     3060

gatgtcaatg agtgcgactc acagccctgc ctgcatggcg gcacctgtca ggacggctgc     3120

ggctcctaca ggtgcacctg cccccagggc tacactggcc ccaactgcca gaaccttgtg     3180

cactggtgtg actcctcgcc ctgcaagaac ggcggcaaat gctggcagac ccacacccag     3240

taccgctgcg agtgccccag cggctggacc ggcctttact gcgacgtgcc cagcgtgtcc     3300

tgtgaggtgg ctgcgcagcg acaaggtgtt gacgttgccc gcctgtgcca gcatggaggg     3360

ctctgtgtgg acgcgggcaa cacgcaccac tgccgctgcc aggcgggcta cacaggcagc     3420

tactgtgagg acctggtgga cgagtgctca cccagcccct gccagaacgg ggccacctgc     3480

acggactacc tgggcggcta ctcctgcaag tgcgtggccg gctaccacgg ggtgaactgc     3540

tctgaggaga tcgacgagtg cctctcccac ccctgccaga acgggggcac ctgcctcgac     3600

ctccccaaca cctacaagtg ctcctgccca cggggcactc agggtgtgca ctgtgagatc     3660

aacgtggacg actgcaatcc ccccgttgac cccgtgtccc ggagccccaa gtgctttaac     3720

aacggcacct gcgtggacca ggtgggcggc tacagctgca cctgcccgcc gggcttcgtg     3780

ggtgagcgct gtgaggggga tgtcaacgag tgcctgtcca atccctgcga cgcccgtggc     3840

acccagaact gcgtgcagcg cgtcaatgac ttccactgcg agtgccgtgc tggtcacacc     3900

gggcgccgct gcgagtccgt catcaatggc tgcaaaggca agccctgcaa gaatgggggc     3960

acctgcgccg tggcctccaa caccgcccgc gggttcatct gcaagtgccc tgcgggcttc     4020

gagggcgcca cgtgtgagaa tgacgctcgt acctgcggca gcctgcgctg cctcaacggc     4080

ggcacatgca tctccggccc gcgcagcccc acctgcctgt gcctgggccc cttcacgggc     4140

cccgaatgcc agttcccggc cagcagcccc tgcctgggcg gcaacccctg ctacaaccag     4200

gggacctgtg agcccacatc cgagagcccc ttctaccgtt gcctgtgccc cgccaaattc     4260

aacgggctct tgtgccacat cctggactac agcttcgggg gtggggccgg gcgcgacatc     4320

cccccgccgc tgatcgagga ggcgtgcgag ctgcccgagt gccaggagga cgcgggcaac     4380

aaggtctgca gcctgcagtg caacaaccac gcgtgcggct gggacggcgg tgactgctcc     4440

ctcaacttca atgacccctg gaagaactgc acgcagtctc tgcagtgctg gaagtacttc     4500

agtgacggcc actgtgacag ccagtgcaac tcagccggct gcctcttcga cggctttgac     4560

tgccagcgtg cggaaggcca gtgcaacccc ctgtacgacc agtactgcaa ggaccacttc     4620

agcgacgggc actgcgacca gggctgcaac agcgcggagt gcgagtggga cgggctggac     4680

tgtgcggagc atgtacccga gaggctggcg gccggcacgc tggtggtggt ggtgctgatg     4740

ccgccggagc agctgcgcaa cagctccttc cacttcctgc gggagctcag ccgcgtgctg     4800

cacaccaacg tggtcttcaa gcgtgacgca cacggccagc agatgatctt cccctactac     4860

ggccgcgagg aggagctgcg caagcacccc atcaagcgtg ccgccgaggg ctgggccgca     4920

cctgacgccc tgctgggcca ggtgaaggcc tcgctgctcc ctggtggcag cgagggtggg     4980

cggcggcgga gggagctgga ccccatggac gtccgcggct ccatcgtcta cctggagatt     5040

gacaaccggc agtgtgtgca ggcctcctcg cagtgcttcc agagtgccac cgacgtggcc     5100

gcattcctgg gagcgctcgc ctcgctgggc agcctcaaca tcccctacaa gatcgaggcc     5160

gtgcagagtg agaccgtgga gccgcccccg ccggcgcagc tgcacttcat gtacgtggcg     5220

gcggccgcct ttgtgcttct gttcttcgtg ggctgcgggg tgctgctgtc ccgcaagcgc     5280

cggcggcagc atggccagct ctggttccct gagggcttca aagtgtctga ggccagcaag     5340

aagaagcggc gggagcccct cggcgaggac tccgtgggcc tcaagcccct gaagaacgct     5400

tcagacggtg ccctcatgga cgacaaccag aatgagtggg gggacgagga cctggagacc     5460

aagaagttcc ggttcgagga gcccgtggtt ctgcctgacc tggacgacca gacagaccac     5520

cggcagtgga ctcagcagca cctggatgcc gctgacctgc gcatgtctgc catggccccc     5580

acaccgcccc agggtgaggt tgacgccgac tgcatggacg tcaatgtccg cgggcctgat     5640

ggcttcaccc cgctcatgat cgcctcctgc agcgggggcg gcctggagac gggcaacagc     5700

gaggaagagg aggacgcgcc ggccgtcatc tccgacttca tctaccaggg cgccagcctg     5760

cacaaccaga cagaccgcac gggcgagacc gccttgcacc tggccgcccg ctactcacgc     5820

tctgatgccg ccaagcgcct gctggaggcc agcgcagatg ccaacatcca ggacaacatg     5880

ggccgcaccc cgctgcatgc ggctgtgtct gccgacgcac aaggtgtctt ccagatcctg     5940

atccggaacc gagccacaga cctggatgcc cgcatgcatg atggcacgac gccactgatc     6000

ctggctgccc gcctggccgt ggagggcatg ctggaggacc tcatcaactc acacgccgac     6060

gtcaacgccg tagatgacct gggcaagtcc gccctgcact gggccgccgc cgtgaacaat     6120

gtggatgccg cagttgtgct cctgaagaac ggggctaaca aagatatgca gaacaacagg     6180

gaggagacac ccctgtttct ggccgcccgg gagggcagct acgagaccgc caaggtgctg     6240

ctggaccact ttgccaaccg ggacatcacg gatcatatgg accgcctgcc gcgcgacatc     6300

gcacaggagc gcatgcatca cgacatcgtg aggctgctgg acgagtacaa cctggtgcgc     6360

agcccgcagc tgcacggagc cccgctgggg ggcacgccca ccctgtcgcc cccgctctgc     6420

tcgcccaacg gctacctggg cagcctcaag cccggcgtgc agggcaagaa ggtccgcaag     6480

cccagcagca aaggcctggc ctgtggaagc aaggaggcca aggacctcaa ggcacggagg     6540

aagaagtccc aggacggcaa gggctgcctg ctggacagct ccggcatgct ctcgcccgtg     6600

gactccctgg agtcacccca tggctacctg tcagacgtgg cctcgccgcc actgctgccc     6660

tccccgttcc agcagtctcc gtccgtgccc ctcaaccacc tgcctgggat gcccgacacc     6720

cacctgggca tcgggcacct gaacgtggcg gccaagcccg agatggcggc gctgggtggg     6780

ggcggccggc tggcctttga gactggccca cctcgtctct cccacctgcc tgtggcctct     6840

ggcaccagca ccgtcctggg ctccagcagc ggaggggccc tgaatttcac tgtgggcggg     6900

tccaccagtt tgaatggtca atgcgagtgg ctgtcccggc tgcagagcgg catggtgccg     6960

aaccaataca accctctgcg ggggagtgtg gcaccaggcc ccctgagcac acaggccccc     7020

tccctgcagc atggcatggt aggcccgctg cacagtagcc ttgctgccag cgccctgtcc     7080

cagatgatga gctaccaggg cctgcccagc acccggctgg ccacccagcc tcacctggtg     7140

cagacccagc aggtgcagcc acaaaactta cagatgcagc agcagaacct gcagccagca     7200

aacatccagc agcagcaaag cctgcagccg ccaccaccac caccacagcc gcaccttggc     7260

gtgagctcag cagccagcgg ccacctgggc cggagcttcc tgagtggaga gccgagccag     7320

gcagacgtgc agccactggg ccccagcagc ctggcggtgc acactattct gccccaggag     7380

agccccgccc tgcccacgtc gctgccatcc tcgctggtcc cacccgtgac cgcagcccag     7440

ttcctgacgc ccccctcgca gcacagctac tcctcgcctg tggacaacac ccccagccac     7500

cagctacagg tgcctgagca ccccttcctc accccgtccc ctgagtcccc tgaccagtgg     7560

tccagctcgt ccccgcattc caacgtctcc gactggtccg agggcgtctc cagccctccc     7620

accagcatgc agtcccagat cgcccgcatt ccggaggcct tcaagtaaac ggcgcgcccc     7680

acgagacccc ggcttccttt cccaagcctt cgggcgtctg tgtgcgctct gtggatgcca     7740

gggccgacca gaggagcctt tttaaaacac atgtttttat acaaaataag aacgaggatt     7800

ttaatttttt ttagtattta tttatgtact tttattttac acagaaacac tgccttttta     7860

tttatatgta ctgttttatc tggccccagg tagaaacttt tatctattct gagaaaacaa     7920

gcaagttctg agagccaggg ttttcctacg taggatgaaa agattcttct gtgtttataa     7980

aatataaaca aagattcatg atttataaat gccatttatt tattgattcc ttttttcaaa     8040

atccaaaaag aaatgatgtt ggagaaggga agttgaacga gcatagtcca aaaagctcct     8100

ggggcgtcca ggccgcgccc tttccccgac gcccacccaa ccccaagcca gcccggccgc     8160

tccaccagca tcacctgcct gttaggagaa gctgcatcca gaggcaaacg gaggcaaagc     8220

tggctcacct tccgcacgcg gattaatttg catctgaaat aggaaacaag tgaaagcata     8280

tgggttagat gttgccatgt gttttagatg gtttcttgca agcatgcttg tgaaaatgtg     8340

ttctcggagt gtgtatgcca agagtgcacc catggtacca atcatgaatc tttgtttcag     8400

gttcagtatt atgtagttgt tcgttggtta tacaagttct tggtccctcc agaaccaccc     8460

cggccccctg cccgttcttg aaatgtaggc atcatgcatg tcaaacatga gatgtgtgga     8520

ctgtggcact tgcctgggtc acacacggag gcatcctacc cttttctggg gaaagacact     8580

gcctgggctg accccggtgg cggccccagc acctcagcct gcacagtgtc ccccaggttc     8640

cgaagaagat gctccagcaa cacagcctgg gccccagctc gcgggacccg accccccgtg     8700

ggctcccgtg ttttgtagga gacttgccag agccgggcac attgagctgt gcaacgccgt     8760

gggctgcgtc ctttggtcct gtccccgcag ccctggcagg gggcatgcgg tcgggcaggg     8820

gctggaggga ggcgggggct gcccttgggc cacccctcct agtttgggag gagcagattt     8880

ttgcaatacc aagtatagcc tatggcagaa aaaatgtctg taaatatgtt tttaaaggtg     8940

gattttgttt aaaaaatctt aatgaatgag tctgttgtgt gtcatgccag tgagggacgt     9000

cagacttggc tcagctcggg gagccttagc cgcccatgca ctggggacgc tccgctgccg     9060

tgccgcctgc actcctcagg gcagcctccc ccggctctac gggggccgcg tggtgccatc     9120

cccagggggc atgaccagat gcgtcccaag atgttgattt ttactgtgtt ttataaaata     9180

gagtgtagtt tacagaaaaa gactttaaaa gtgatctaca tgaggaactg tagatgatgt     9240

atttttttca tcttttttgt taactgattt gcaataaaaa tgatactgat ggtgatctgg     9300

cttccaaaaa aaaaaaaaaa aa                                              9322


<210>  15
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  16
<211>  6574
<212>  DNA
<213>  Homo sapiens

<400>  16
aagagcaaaa agcgaaggcg caatctggac actgggagat tcggagcgca gggagtttga       60

gagaaacttt tattttgaag agaccaaggt tgaggggggg cttatttcct gacagctatt      120

tacttagagc aaatgattag ttttagaagg atggactata acattgaatc aattacaaaa      180

cgcggttttt gagcccatta ctgttggagc tacagggaga gaaacagagg aggagactgc      240

aagagatcat tggaggccgt gggcacgctc tttactccat gtgtgggaca ttcattgcgg      300

aataacatcg gaggagaagt ttcccagagc tatggggact tcccatccgg cgttcctggt      360

cttaggctgt cttctcacag ggctgagcct aatcctctgc cagctttcat taccctctat      420

ccttccaaat gaaaatgaaa aggttgtgca gctgaattca tccttttctc tgagatgctt      480

tggggagagt gaagtgagct ggcagtaccc catgtctgaa gaagagagct ccgatgtgga      540

aatcagaaat gaagaaaaca acagcggcct ttttgtgacg gtcttggaag tgagcagtgc      600

ctcggcggcc cacacagggt tgtacacttg ctattacaac cacactcaga cagaagagaa      660

tgagcttgaa ggcaggcaca tttacatcta tgtgccagac ccagatgtag cctttgtacc      720

tctaggaatg acggattatt tagtcatcgt ggaggatgat gattctgcca ttataccttg      780

tcgcacaact gatcccgaga ctcctgtaac cttacacaac agtgaggggg tggtacctgc      840

ctcctacgac agcagacagg gctttaatgg gaccttcact gtagggccct atatctgtga      900

ggccaccgtc aaaggaaaga agttccagac catcccattt aatgtttatg ctttaaaagc      960

aacatcagag ctggatctag aaatggaagc tcttaaaacc gtgtataagt caggggaaac     1020

gattgtggtc acctgtgctg tttttaacaa tgaggtggtt gaccttcaat ggacttaccc     1080

tggagaagtg aaaggcaaag gcatcacaat gctggaagaa atcaaagtcc catccatcaa     1140

attggtgtac actttgacgg tccccgaggc cacggtgaaa gacagtggag attacgaatg     1200

tgctgcccgc caggctacca gggaggtcaa agaaatgaag aaagtcacta tttctgtcca     1260

tgagaaaggt ttcattgaaa tcaaacccac cttcagccag ttggaagctg tcaacctgca     1320

tgaagtcaaa cattttgttg tagaggtgcg ggcctaccca cctcccagga tatcctggct     1380

gaaaaacaat ctgactctga ttgaaaatct cactgagatc accactgatg tggaaaagat     1440

tcaggaaata aggtatcgaa gcaaattaaa gctgatccgt gctaaggaag aagacagtgg     1500

ccattatact attgtagctc aaaatgaaga tgctgtgaag agctatactt ttgaactgtt     1560

aactcaagtt ccttcatcca ttctggactt ggtcgatgat caccatggct caactggggg     1620

acagacggtg aggtgcacag ctgaaggcac gccgcttcct gatattgagt ggatgatatg     1680

caaagatatt aagaaatgta ataatgaaac ttcctggact attttggcca acaatgtctc     1740

aaacatcatc acggagatcc actcccgaga caggagtacc gtggagggcc gtgtgacttt     1800

cgccaaagtg gaggagacca tcgccgtgcg atgcctggct aagaatctcc ttggagctga     1860

gaaccgagag ctgaagctgg tggctcccac cctgcgttct gaactcacgg tggctgctgc     1920

agtcctggtg ctgttggtga ttgtgatcat ctcacttatt gtcctggttg tcatttggaa     1980

acagaaaccg aggtatgaaa ttcgctggag ggtcattgaa tcaatcagcc cagatggaca     2040

tgaatatatt tatgtggacc cgatgcagct gccttatgac tcaagatggg agtttccaag     2100

agatggacta gtgcttggtc gggtcttggg gtctggagcg tttgggaagg tggttgaagg     2160

aacagcctat ggattaagcc ggtcccaacc tgtcatgaaa gttgcagtga agatgctaaa     2220

acccacggcc agatccagtg aaaaacaagc tctcatgtct gaactgaaga taatgactca     2280

cctggggcca catttgaaca ttgtaaactt gctgggagcc tgcaccaagt caggccccat     2340

ttacatcatc acagagtatt gcttctatgg agatttggtc aactatttgc ataagaatag     2400

ggatagcttc ctgagccacc acccagagaa gccaaagaaa gagctggata tctttggatt     2460

gaaccctgct gatgaaagca cacggagcta tgttatttta tcttttgaaa acaatggtga     2520

ctacatggac atgaagcagg ctgatactac acagtatgtc cccatgctag aaaggaaaga     2580

ggtttctaaa tattccgaca tccagagatc actctatgat cgtccagcct catataagaa     2640

gaaatctatg ttagactcag aagtcaaaaa cctcctttca gatgataact cagaaggcct     2700

tactttattg gatttgttga gcttcaccta tcaagttgcc cgaggaatgg agtttttggc     2760

ttcaaaaaat tgtgtccacc gtgatctggc tgctcgcaac gtcctcctgg cacaaggaaa     2820

aattgtgaag atctgtgact ttggcctggc cagagacatc atgcatgatt cgaactatgt     2880

gtcgaaaggc agtacctttc tgcccgtgaa gtggatggct cctgagagca tctttgacaa     2940

cctctacacc acactgagtg atgtctggtc ttatggcatt ctgctctggg agatcttttc     3000

ccttggtggc accccttacc ccggcatgat ggtggattct actttctaca ataagatcaa     3060

gagtgggtac cggatggcca agcctgacca cgctaccagt gaagtctacg agatcatggt     3120

gaaatgctgg aacagtgagc cggagaagag accctccttt taccacctga gtgagattgt     3180

ggagaatctg ctgcctggac aatataaaaa gagttatgaa aaaattcacc tggacttcct     3240

gaagagtgac catcctgctg tggcacgcat gcgtgtggac tcagacaatg catacattgg     3300

tgtcacctac aaaaacgagg aagacaagct gaaggactgg gagggtggtc tggatgagca     3360

gagactgagc gctgacagtg gctacatcat tcctctgcct gacattgacc ctgtccctga     3420

ggaggaggac ctgggcaaga ggaacagaca cagctcgcag acctctgaag agagtgccat     3480

tgagacgggt tccagcagtt ccaccttcat caagagagag gacgagacca ttgaagacat     3540

cgacatgatg gatgacatcg gcatagactc ttcagacctg gtggaagaca gcttcctgta     3600

actggcggat tcgaggggtt ccttccactt ctggggccac ctctggatcc cgttcagaaa     3660

accactttat tgcaatgcag aggttgagag gaggacttgg ttgatgttta aagagaagtt     3720

cccagccaag ggcctcgggg agcgttctaa atatgaatga atgggatatt ttgaaatgaa     3780

ctttgtcagt gttgcctctt gcaatgcctc agtagcatct cagtggtgtg tgaagtttgg     3840

agatagatgg ataagggaat aataggccac agaaggtgaa ctttgtgctt caaggacatt     3900

ggtgagagtc caacagacac aatttatact gcgacagaac ttcagcattg taattatgta     3960

aataactcta accaaggctg tgtttagatt gtattaacta tcttctttgg acttctgaag     4020

agaccactca atccatccat gtacttccct cttgaaacct gatgtcagct gctgttgaac     4080

tttttaaaga agtgcatgaa aaaccatttt tgaaccttaa aaggtactgg tactatagca     4140

ttttgctatc ttttttagtg ttaaagagat aaagaataat aattaaccaa ccttgtttaa     4200

tagatttggg tcatttagaa gcctgacaac tcattttcat attgtaatct atgtttataa     4260

tactactact gttatcagta atgctaaatg tgtaataatg taacatgatt tccctccaga     4320

gaaagcacaa tttaaaacaa tccttactaa gtaggtgatg agtttgacag tttttgacat     4380

ttatattaaa taacatgttt ctctataaag tatggtaata gctttagtga attaaattta     4440

gttgagcata gagaacaaag taaaagtagt gttgtccagg aagtcagaat ttttaactgt     4500

actgaatagg ttccccaatc catcgtatta aaaaacaatt aactgccctc tgaaataatg     4560

ggattagaaa caaacaaaac tcttaagtcc taaaagttct caatgtagag gcataaacct     4620

gtgctgaaca taacttctca tgtatattac ccaatggaaa atataatgat cagcaaaaag     4680

actggatttg cagaagtttt tttttttttt ttcttcatgc ctgatgaaag ctttggcgac     4740

cccaatatat gtattttttg aatctatgaa cctgaaaagg gtcagaagga tgcccagaca     4800

tcagcctcct tctttcaccc cttaccccaa agagaaagag tttgaaactc gagaccataa     4860

agatattctt tagtggaggc tggatgtgca ttagcctgga tcctcagttc tcaaatgtgt     4920

gtggcagcca ggatgactag atcctgggtt tccatccttg agattctgaa gtatgaagtc     4980

tgagggaaac cagagtctgt atttttctaa actccctggc tgttctgatc ggccagtttt     5040

cggaaacact gacttaggtt tcaggaagtt gccatgggaa acaaataatt tgaactttgg     5100

aacagggttg gcattcaacc acgcaggaag cctactattt aaatccttgg cttcaggtta     5160

gtgacattta atgccatcta gctagcaatt gcgaccttaa tttaactttc cagtcttagc     5220

tgaggctgag aaagctaaag tttggttttg acaggttttc caaaagtaaa gatgctactt     5280

cccactgtat gggggagatt gaactttccc cgtctcccgt cttctgcctc ccactccata     5340

ccccgccaag gaaaggcatg tacaaaaatt atgcaattca gtgttccaag tctctgtgta     5400

accagctcag tgttttggtg gaaaaaacat tttaagtttt actgataatt tgaggttaga     5460

tgggaggatg aattgtcaca tctatccaca ctgtcaaaca ggttggtgtg ggttcattgg     5520

cattctttgc aatactgctt aattgctgat accatatgaa tgaaacatgg gctgtgatta     5580

ctgcaatcac tgtgctatcg gcagatgatg ctttggaaga tgcagaagca ataataaagt     5640

acttgactac ctactggtgt aatctcaatg caagccccaa ctttcttatc caactttttc     5700

atagtaagtg cgaagactga gccagattgg ccaattaaaa acgaaaacct gactaggttc     5760

tgtagagcca attagacttg aaatacgttt gtgtttctag aatcacagct caagcattct     5820

gtttatcgct cactctccct tgtacagcct tattttgttg gtgctttgca ttttgatatt     5880

gctgtgagcc ttgcatgaca tcatgaggcc ggatgaaact tctcagtcca gcagtttcca     5940

gtcctaacaa atgctcccac ctgaatttgt atatgactgc atttgtgtgt gtgtgtgtgt     6000

tttcagcaaa ttccagattt gtttcctttt ggcctcctgc aaagtctcca gaagaaaatt     6060

tgccaatctt tcctactttc tatttttatg atgacaatca aagccggcct gagaaacact     6120

atttgtgact ttttaaacga ttagtgatgt ccttaaaatg tggtctgcca atctgtacaa     6180

aatggtccta tttttgtgaa gagggacata agataaaatg atgttataca tcaatatgta     6240

tatatgtatt tctatataga cttggagaat actgccaaaa catttatgac aagctgtatc     6300

actgccttcg tttatatttt tttaactgtg ataatcccca caggcacatt aactgttgca     6360

cttttgaatg tccaaaattt atattttaga aataataaaa agaaagatac ttacatgttc     6420

ccaaaacaat ggtgtggtga atgtgtgaga aaaactaact tgatagggtc taccaataca     6480

aaatgtatta cgaatgcccc tgttcatgtt tttgttttaa aacgtgtaaa tgaagatctt     6540

tatatttcaa taaatgatat ataatttaaa gtta                                 6574


<210>  17
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Arg Arg Lys Gln Arg Lys Pro Gln Gln Leu Ile Ser Asp Cys 
1               5                   10                  15      


Glu Gly Pro Ser Ala Ser Glu Asn Gly Asp Ala Ser Glu Glu Asp His 
            20                  25                  30          


Pro Gln Val Cys Ala Lys Cys Cys Ala Gln Phe Thr Asp Pro Thr Glu 
        35                  40                  45              


Phe Leu Ala His Gln Asn Ala Cys Ser Thr Asp Pro Pro Val Met Val 
    50                  55                  60                  


Ile Ile Gly Gly Gln Glu Asn Pro Asn Asn Ser Ser Ala Ser Ser Glu 
65                  70                  75                  80  


Pro Arg Pro Glu Gly His Asn Asn Pro Gln Val Met Asp Thr Glu His 
                85                  90                  95      


Ser Asn Pro Pro Asp Ser Gly Ser Ser Val Pro Thr Asp Pro Thr Trp 
            100                 105                 110         


Gly Pro Glu Arg Arg Gly Glu Glu Ser Pro Gly His Phe Leu Val Ala 
        115                 120                 125             


Ala Thr Gly Thr Ala Ala Gly Gly Gly Gly Gly Leu Ile Leu Ala Ser 
    130                 135                 140                 


Pro Lys Leu Gly Ala Thr Pro Leu Pro Pro Glu Ser Thr Pro Ala Pro 
145                 150                 155                 160 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Val Gly Ser Gly His 
                165                 170                 175     


Leu Asn Ile Pro Leu Ile Leu Glu Glu Leu Arg Val Leu Gln Gln Arg 
            180                 185                 190         


Gln Ile His Gln Met Gln Met Thr Glu Gln Ile Cys Arg Gln Val Leu 
        195                 200                 205             


Leu Leu Gly Ser Leu Gly Gln Thr Val Gly Ala Pro Ala Ser Pro Ser 
    210                 215                 220                 


Glu Leu Pro Gly Thr Gly Thr Ala Ser Ser Thr Lys Pro Leu Leu Pro 
225                 230                 235                 240 


Leu Phe Ser Pro Ile Lys Pro Val Gln Thr Ser Lys Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Glu Thr Pro Lys Gln 
            260                 265                 270         


Ala Phe Phe His Leu Tyr His Pro Leu Gly Ser Gln His Pro Phe Ser 
        275                 280                 285             


Ala Gly Gly Val Gly Arg Ser His Lys Pro Thr Pro Ala Pro Ser Pro 
    290                 295                 300                 


Ala Leu Pro Gly Ser Thr Asp Gln Leu Ile Ala Ser Pro His Leu Ala 
305                 310                 315                 320 


Phe Pro Ser Thr Thr Gly Leu Leu Ala Ala Gln Cys Leu Gly Ala Ala 
                325                 330                 335     


Arg Gly Leu Glu Ala Thr Ala Ser Pro Gly Leu Leu Lys Pro Lys Asn 
            340                 345                 350         


Gly Ser Gly Glu Leu Ser Tyr Gly Glu Val Met Gly Pro Leu Glu Lys 
        355                 360                 365             


Pro Gly Gly Arg His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser 
    370                 375                 380                 


Asp Ser Ala Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro 
385                 390                 395                 400 


Tyr Lys Cys Asn Val Cys Gly Asn Arg Phe Thr Thr Arg Gly Asn Leu 
                405                 410                 415     


Lys Val His Phe His Arg His Arg Glu Lys Tyr Pro His Val Gln Met 
            420                 425                 430         


Asn Pro His Pro Val Pro Glu His Leu Asp Tyr Val Ile Thr Ser Ser 
        435                 440                 445             


Gly Leu Pro Tyr Gly Met Ser Val Pro Pro Glu Lys Ala Glu Glu Glu 
    450                 455                 460                 


Ala Ala Thr Pro Gly Gly Gly Val Glu Arg Lys Pro Leu Val Ala Ser 
465                 470                 475                 480 


Thr Thr Ala Leu Ser Ala Thr Glu Ser Leu Thr Leu Leu Ser Thr Ser 
                485                 490                 495     


Ala Gly Thr Ala Thr Ala Pro Gly Leu Pro Ala Phe Asn Lys Phe Val 
            500                 505                 510         


Leu Met Lys Ala Val Glu Pro Lys Asn Lys Ala Asp Glu Asn Thr Pro 
        515                 520                 525             


Pro Gly Ser Glu Gly Ser Ala Ile Ser Gly Val Ala Glu Ser Ser Thr 
    530                 535                 540                 


Ala Thr Arg Met Gln Leu Ser Lys Leu Val Thr Ser Leu Pro Ser Trp 
545                 550                 555                 560 


Ala Leu Leu Thr Asn His Phe Lys Ser Thr Gly Ser Phe Pro Phe Pro 
                565                 570                 575     


Tyr Val Leu Glu Pro Leu Gly Ala Ser Pro Ser Glu Thr Ser Lys Leu 
            580                 585                 590         


Gln Gln Leu Val Glu Lys Ile Asp Arg Gln Gly Ala Val Ala Val Thr 
        595                 600                 605             


Ser Ala Ala Ser Gly Ala Pro Thr Thr Ser Ala Pro Ala Pro Ser Ser 
    610                 615                 620                 


Ser Ala Ser Ser Gly Pro Asn Gln Cys Val Ile Cys Leu Arg Val Leu 
625                 630                 635                 640 


Ser Cys Pro Arg Ala Leu Arg Leu His Tyr Gly Gln His Gly Gly Glu 
                645                 650                 655     


Arg Pro Phe Lys Cys Lys Val Cys Gly Arg Ala Phe Ser Thr Arg Gly 
            660                 665                 670         


Asn Leu Arg Ala His Phe Val Gly His Lys Ala Ser Pro Ala Ala Arg 
        675                 680                 685             


Ala Gln Asn Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val 
    690                 695                 700                 


Thr Leu Gln Gln His Val Arg Met His Leu Gly Gly Gln Ile Pro Asn 
705                 710                 715                 720 


Gly Gly Thr Ala Leu Pro Glu Gly Gly Gly Ala Ala Gln Glu Asn Gly 
                725                 730                 735     


Ser Glu Gln Ser Thr Val Ser Gly Ala Gly Ser Phe Pro Gln Gln Gln 
            740                 745                 750         


Ser Gln Gln Pro Ser Pro Glu Glu Glu Leu Ser Glu Glu Glu Glu Glu 
        755                 760                 765             


Glu Asp Glu Glu Glu Glu Glu Asp Val Thr Asp Glu Asp Ser Leu Ala 
    770                 775                 780                 


Gly Arg Gly Ser Glu Ser Gly Gly Glu Lys Ala Ile Ser Val Arg Gly 
785                 790                 795                 800 


Asp Ser Glu Glu Ala Ser Gly Ala Glu Glu Glu Val Gly Thr Val Ala 
                805                 810                 815     


Ala Ala Ala Thr Ala Gly Lys Glu Met Asp Ser Asn Glu Lys Thr Thr 
            820                 825                 830         


Gln Gln Ser Ser Leu Pro Pro Pro Pro Pro Pro Asp Ser Leu Asp Gln 
        835                 840                 845             


Pro Gln Pro Met Glu Gln Gly Ser Ser Gly Val Leu Gly Gly Lys Glu 
    850                 855                 860                 


Glu Gly Gly Lys Pro Glu Arg Ser Ser Ser Pro Ala Ser Ala Leu Thr 
865                 870                 875                 880 


Pro Glu Gly Glu Ala Thr Ser Val Thr Leu Val Glu Glu Leu Ser Leu 
                885                 890                 895     


Gln Glu Ala Met Arg Lys Glu Pro Gly Glu Ser Ser Ser Arg Lys Ala 
            900                 905                 910         


Cys Glu Val Cys Gly Gln Ala Phe Pro Ser Gln Ala Ala Leu Glu Glu 
        915                 920                 925             


His Gln Lys Thr His Pro Lys Glu Gly Pro Leu Phe Thr Cys Val Phe 
    930                 935                 940                 


Cys Arg Gln Gly Phe Leu Glu Arg Ala Thr Leu Lys Lys His Met Leu 
945                 950                 955                 960 


Leu Ala His His Gln Val Gln Pro Phe Ala Pro His Gly Pro Gln Asn 
                965                 970                 975     


Ile Ala Ala Leu Ser Leu Val Pro Gly Cys Ser Pro Ser Ile Thr Ser 
            980                 985                 990         


Thr Gly Leu Ser Pro Phe Pro Arg  Lys Asp Asp Pro Thr  Ile Pro 
        995                 1000                 1005         


<210>  18
<211>  4931
<212>  DNA
<213>  Homo sapiens

<400>  18
gagctgcaga agcgtaggga agaagctgaa gaaaaaaagg gggcgtctcc cctttaaaga       60

cttgcaaaga ttgagagaga aagagagaga gtcaagaaca gagaatcaga gagagagaga      120

gagtctgtgt ctctgggaaa gaagaacatc tctgcttcac agtgatttgc gctgggggag      180

aggcatcaat tggcttcgga cccaaggggg agacgagacc aggtcacccc ggttaagacc      240

aagtgagcgt tgcccctccc tctcccaact ctctacccgg gaatgtctcg gcgaaagcag      300

cggaaacccc aacagttaat ctcggactgc gaaggtccca gcgcgtctga gaacggtgat      360

gctagcgagg aggatcaccc ccaagtctgt gccaagtgct gcgcacaatt cactgaccca      420

actgaattcc tcgcccacca gaacgcatgt tctactgacc ctcctgtaat ggtgataatt      480

gggggccagg agaaccccaa caactcttcg gcctcctctg aaccccggcc tgagggtcac      540

aataatcctc aggtcatgga cacagagcat agcaaccccc cagattctgg gtcctccgtg      600

cccacggatc ccacctgggg cccagagagg agaggagagg agtctccagg gcatttcctg      660

gtcgctgcca caggtacagc ggctggggga ggcgggggcc tgatcttggc cagtcccaag      720

ctgggagcaa ccccattacc tccagaatcg acccctgcac cccctcctcc tccaccaccc      780

cctccgcccc caggggtagg cagtggccac ttgaatatcc ccctgatctt ggaagagcta      840

cgggtgctgc agcagcggca gatccatcag atgcagatga ctgagcaaat ctgcaggcag      900

gtgctgttgc ttggctcctt aggccagacg gtgggtgccc ctgccagtcc ctcagagcta      960

cctgggacag ggactgcctc ttccaccaag cccctactac ccctcttcag ccccatcaag     1020

cctgtccaaa ccagcaagac actggcatct tcctcctcct cctcctcttc ctcttcaggg     1080

gcagaaacgc ccaagcaggc cttcttccac ctttaccacc cactggggtc acagcatcct     1140

ttctctgctg gaggggttgg gcgaagccac aaacccaccc ctgccccttc cccagccttg     1200

ccaggcagca cagatcagct gattgcctcg cctcatctgg cattcccaag caccacggga     1260

ctactggcag cacagtgtct tggggcagcc cgaggccttg aggccactgc ctccccaggg     1320

ctcctgaagc caaagaatgg aagtggtgag ctgagctacg gagaagtgat gggtcccttg     1380

gagaagcctg gtggaaggca caaatgccgc ttctgtgcca aagtatttgg cagtgacagt     1440

gccctgcaga tccaccttcg ttcccacacg ggtgagaggc cctataagtg caatgtctgt     1500

ggaaaccgtt ttaccacccg tggcaacctc aaagtgcatt tccaccggca tcgtgagaag     1560

tacccacatg tgcagatgaa cccacaccca gtaccagagc acctagacta tgtcattacc     1620

agcagtggct tgccttatgg tatgtccgtg ccaccagaga aggccgagga ggaggcagcc     1680

actccaggtg gaggggttga gcgcaagcct ctggtggcct ccacaacagc actcagtgcc     1740

acagagagcc tgactctgct ctccaccagt gcaggcacag ccacggctcc aggactccct     1800

gctttcaata agtttgtgct catgaaagca gtggaaccca agaataaagc tgatgaaaac     1860

acccccccag ggagtgaggg ctcagccatc agtggagtgg cagaaagtag cacggcaact     1920

cgcatgcaac taagtaagtt ggtgacttca ctaccaagct gggcactgct taccaaccac     1980

ttcaagtcca ctggcagctt ccccttcccc tatgtgctag agcccttggg ggcctcaccc     2040

tctgagacat caaagctgca gcaactggta gaaaagattg accggcaagg agctgtggcg     2100

gtgacctcag ctgcctcagg agcccccacc acctctgccc ctgcaccttc atcctcagcc     2160

tcttctggac ctaaccagtg tgtcatctgt ctccgagtgc ttagctgtcc tcgggcccta     2220

cgccttcatt atggccaaca tggaggtgag aggcccttca aatgcaaagt gtgtggcaga     2280

gccttctcca ccaggggtaa tctgcgtgca catttcgtgg gccacaaggc cagtccagct     2340

gcccgggcac agaattcctg ccccatctgc cagaagaagt tcaccaatgc tgtcactctg     2400

cagcagcatg tccggatgca cctggggggc cagatcccca acggtggtac tgcactccct     2460

gaaggtggag gagctgctca ggagaatggc tccgagcaat ctacagtctc cggggcaggg     2520

agtttccccc agcagcagtc ccagcagcca tcaccggaag aggagttgtc tgaggaggag     2580

gaagaggagg atgaggaaga agaggaagat gtgactgatg aagattccct ggcagggaga     2640

ggctcagaga gtggaggtga gaaggcaata tcagtgagag gtgattcaga agaggcatct     2700

ggggcagagg aggaggtggg gacagtggcg gcagcagcca cagctgggaa ggagatggac     2760

agtaatgaga aaactactca acagtcttct ttgccaccac caccaccacc tgacagcctg     2820

gatcagcctc agccaatgga gcagggaagc agtggtgttt taggaggcaa ggaagagggg     2880

ggcaaaccgg agagaagctc aagtccggca tcagcactca ccccagaagg ggaagccacc     2940

agcgtgacct tggtagagga gctgagcctg caggaggcaa tgagaaagga gccaggagag     3000

agcagcagca gaaaggcctg cgaagtgtgt ggccaggcct ttccctccca ggcagctctg     3060

gaggagcatc agaagaccca ccccaaggag gggccgctct tcacttgtgt tttctgcagg     3120

cagggctttc ttgagcgggc taccctcaag aagcatatgc tcctggcaca ccaccaggta     3180

cagccctttg ccccccatgg ccctcagaat attgctgctc tttctctagt ccctggctgt     3240

tcgccttcca tcacctccac agggctctcc ccctttcccc gaaaagatga ccccacgatc     3300

ccatgagcct gtttttctgt acctgctgct ctttgtccca cagagcagaa acagcttcac     3360

aaaaggacct cccagagtta tgagccctga ttttgtcttt ttctctaagt tcttaacatg     3420

ttatgtccct agtggctttt ctgtagtccc tgagcttgga aattactgtg cttacaaggg     3480

gatggccccc taaggaattt ttcttccctc ctcattcttt gtacctgagg aacatagatt     3540

ctctgcagct ttctcaaggg gaaccctctc cagcttccct ggtgtgaccc ttcttccccc     3600

tcctctctcc tctccctttc cctttggtag gtgcacctga gcacctacat ttggcattgc     3660

agcctagcca aaaagggctg gcagctgtct ctggagggcc cagtgccact cctctggggt     3720

gacctttctg ctcagctggt gggtatgggt cccctatctt tctagaacca gtatgtggca     3780

ttcctgtcaa atggcctgcc catgaagccc tggaattcca gctccacctc cactaccact     3840

ccaagcctgg ccccaccagt gctgtttggc ctaggaactg tggctgggaa ggtgcctcca     3900

acaatgggat ccagggaagc caaggagaag acagcccccc tcctatttca gcctcctgca     3960

cccaaggcag tgcctgagaa gcccatcata gacaagaagt agcaaactgt acattccttc     4020

ttcctccccc tgctccagaa ggtgccggta ctgaagatgc tccagtaatt ggtgacccaa     4080

ccctaggaag tagggagaaa tgaaggaagg gcataggaaa attttcccag taaatcccct     4140

gatggtcaca ttaaggtaaa ggttttggct ggtcagtgtg ccaagacctc tccagcttct     4200

cattcatgat gacctctcaa agttgggaaa caagctgatt tcttgccaag aggtctccca     4260

ggagatattt gggaaatgtg aagttcgtat ctttaaggag catttttggt cagcatggtt     4320

gatgaactaa tgatgagaga gttaaggaat gttgctagaa catagggctt gctggtacct     4380

atgtgactaa gaaagggaca tgatgtaagg gaaaaggcct caaattcttg tgaatgtgga     4440

cattctcgtt aatattcttt tgggctaata gtgacatagt gtgcagaggt gtaccaggga     4500

tcatggggga tttcctagca ctagtatgct tctagtttta gataactccc tcctttattc     4560

cctggcccct tgtattttcc ttatcttcct ctttcaagac ccctacccat tttgcctatc     4620

cgtaggctgg ggcttgtgtc tttgtcattg tctggttctt aagagtccca gctccaggtg     4680

gcgtcctccc tgcctctccg tcttgtaatg agttgtagta tttactctta acataggatc     4740

atttggaaca ggagttctga ggaggagaga gtgagggttt tgctattgac tgacttgaac     4800

gatggcttct cctcaagctg taggctccag agcttcctaa cctagtaaaa tgtcaagaac     4860

agacgggaga tattagtgtc tttccctcta tcattaaagg tgttttaacc aaaaaaaaaa     4920

aaaaaaaaaa a                                                          4931


<210>  19
<211>  3616
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Thr Cys Asp Ser Pro Pro Ile Ser Arg Gln Glu Asn Gly Gln 
1               5                   10                  15      


Ser Thr Ser Lys Leu Cys Gly Thr Thr Gln Leu Asp Asn Glu Val Pro 
            20                  25                  30          


Glu Lys Val Ala Gly Met Glu Pro Asp Arg Glu Asn Ser Ser Thr Asp 
        35                  40                  45              


Asp Asn Leu Lys Thr Asp Glu Arg Lys Ser Glu Ala Leu Leu Gly Phe 
    50                  55                  60                  


Ser Val Glu Asn Ala Ala Ala Thr Gln Val Thr Ser Ala Lys Glu Ile 
65                  70                  75                  80  


Pro Cys Asn Glu Cys Ala Thr Ser Phe Pro Ser Leu Gln Lys Tyr Met 
                85                  90                  95      


Glu His His Cys Pro Asn Ala Arg Leu Pro Val Leu Lys Asp Asp Asn 
            100                 105                 110         


Glu Ser Glu Ile Ser Glu Leu Glu Asp Ser Asp Val Glu Asn Leu Thr 
        115                 120                 125             


Gly Glu Ile Val Tyr Gln Pro Asp Gly Ser Ala Tyr Ile Ile Glu Asp 
    130                 135                 140                 


Ser Lys Glu Ser Gly Gln Asn Ala Gln Thr Gly Ala Asn Ser Lys Leu 
145                 150                 155                 160 


Phe Ser Thr Ala Met Phe Leu Asp Ser Leu Ala Ser Ala Gly Glu Lys 
                165                 170                 175     


Ser Asp Gln Ser Ala Ser Ala Pro Met Ser Phe Tyr Pro Gln Ile Ile 
            180                 185                 190         


Asn Thr Phe His Ile Ala Ser Ser Leu Gly Lys Pro Phe Thr Ala Asp 
        195                 200                 205             


Gln Ala Phe Pro Asn Thr Ser Ala Leu Ala Gly Val Gly Pro Val Leu 
    210                 215                 220                 


His Ser Phe Arg Val Tyr Asp Leu Arg His Lys Arg Glu Lys Asp Tyr 
225                 230                 235                 240 


Leu Thr Ser Asp Gly Ser Ala Lys Asn Ser Cys Val Ser Lys Asp Val 
                245                 250                 255     


Pro Asn Asn Val Asp Leu Ser Lys Phe Asp Gly Cys Val Ser Asp Gly 
            260                 265                 270         


Lys Arg Lys Pro Val Leu Met Cys Phe Leu Cys Lys Leu Ser Phe Gly 
        275                 280                 285             


Tyr Ile Arg Ser Phe Val Thr His Ala Val His Asp His Arg Met Thr 
    290                 295                 300                 


Leu Asn Asp Glu Glu Gln Lys Leu Leu Ser Asn Lys Cys Val Ser Ala 
305                 310                 315                 320 


Ile Ile Gln Gly Ile Gly Lys Asp Lys Glu Pro Leu Ile Ser Phe Leu 
                325                 330                 335     


Glu Pro Lys Lys Ser Thr Ser Val Tyr Pro His Phe Ser Thr Thr Asn 
            340                 345                 350         


Leu Ile Gly Pro Asp Pro Thr Phe Arg Gly Leu Trp Ser Ala Phe His 
        355                 360                 365             


Val Glu Asn Gly Asp Ser Leu Pro Ala Gly Phe Ala Phe Leu Lys Gly 
    370                 375                 380                 


Ser Ala Ser Thr Ser Ser Ser Ala Glu Gln Pro Leu Gly Ile Thr Gln 
385                 390                 395                 400 


Met Pro Lys Ala Glu Val Asn Leu Gly Gly Leu Ser Ser Leu Val Val 
                405                 410                 415     


Asn Thr Pro Ile Thr Ser Val Ser Leu Ser His Ser Ser Ser Glu Ser 
            420                 425                 430         


Ser Lys Met Ser Glu Ser Lys Asp Gln Glu Asn Asn Cys Glu Arg Pro 
        435                 440                 445             


Lys Glu Ser Asn Val Leu His Pro Asn Gly Glu Cys Pro Val Lys Ser 
    450                 455                 460                 


Glu Pro Thr Glu Pro Gly Asp Glu Asp Glu Glu Asp Ala Tyr Ser Asn 
465                 470                 475                 480 


Glu Leu Asp Asp Glu Glu Val Leu Gly Glu Leu Thr Asp Ser Ile Gly 
                485                 490                 495     


Asn Lys Asp Phe Pro Leu Leu Asn Gln Ser Ile Ser Pro Leu Ser Ser 
            500                 505                 510         


Ser Val Leu Lys Phe Ile Glu Lys Gly Thr Ser Ser Ser Ser Ala Thr 
        515                 520                 525             


Val Ser Asp Asp Thr Glu Lys Lys Lys Gln Thr Ala Ala Val Arg Ala 
    530                 535                 540                 


Ser Gly Ser Val Ala Ser Asn Tyr Gly Ile Ser Gly Lys Asp Phe Ala 
545                 550                 555                 560 


Asp Ala Ser Ala Ser Lys Asp Ser Ala Thr Ala Ala His Pro Ser Glu 
                565                 570                 575     


Ile Ala Arg Gly Asp Glu Asp Ser Ser Ala Thr Pro His Gln His Gly 
            580                 585                 590         


Phe Thr Pro Ser Thr Pro Gly Thr Pro Gly Pro Gly Gly Asp Gly Ser 
        595                 600                 605             


Pro Gly Ser Gly Ile Glu Cys Pro Lys Cys Asp Thr Val Leu Gly Ser 
    610                 615                 620                 


Ser Arg Ser Leu Gly Gly His Met Thr Met Met His Ser Arg Asn Ser 
625                 630                 635                 640 


Cys Lys Thr Leu Lys Cys Pro Lys Cys Asn Trp His Tyr Lys Tyr Gln 
                645                 650                 655     


Gln Thr Leu Glu Ala His Met Lys Glu Lys His Pro Glu Pro Gly Gly 
            660                 665                 670         


Ser Cys Val Tyr Cys Lys Thr Gly Gln Pro His Pro Arg Leu Ala Arg 
        675                 680                 685             


Gly Glu Ser Tyr Thr Cys Gly Tyr Lys Pro Phe Arg Cys Glu Val Cys 
    690                 695                 700                 


Asn Tyr Ser Thr Thr Thr Lys Gly Asn Leu Ser Ile His Met Gln Ser 
705                 710                 715                 720 


Asp Lys His Leu Asn Asn Val Gln Asn Leu Gln Asn Gly Asn Gly Glu 
                725                 730                 735     


Gln Val Phe Gly His Ser Ala Pro Ala Pro Asn Thr Ser Leu Ser Gly 
            740                 745                 750         


Cys Gly Thr Pro Ser Pro Ser Lys Pro Lys Gln Lys Pro Thr Trp Arg 
        755                 760                 765             


Cys Glu Val Cys Asp Tyr Glu Thr Asn Val Ala Arg Asn Leu Arg Ile 
    770                 775                 780                 


His Met Thr Ser Glu Lys His Met His Asn Met Met Leu Leu Gln Gln 
785                 790                 795                 800 


Asn Met Lys Gln Ile Gln His Asn Leu His Leu Gly Leu Ala Pro Ala 
                805                 810                 815     


Glu Ala Glu Leu Tyr Gln Tyr Tyr Leu Ala Gln Asn Ile Gly Leu Thr 
            820                 825                 830         


Gly Met Lys Leu Glu Asn Pro Ala Asp Pro Gln Leu Met Ile Asn Pro 
        835                 840                 845             


Phe Gln Leu Asp Pro Ala Thr Ala Ala Ala Leu Ala Pro Gly Leu Val 
    850                 855                 860                 


Asn Asn Glu Leu Pro Pro Glu Ile Arg Leu Ala Ser Gly Gln Leu Met 
865                 870                 875                 880 


Gly Asp Asp Leu Ser Leu Leu Thr Ala Gly Glu Leu Ser Pro Tyr Ile 
                885                 890                 895     


Ser Asp Pro Ala Leu Lys Leu Phe Gln Cys Ala Val Cys Asn Lys Phe 
            900                 905                 910         


Thr Ser Asp Ser Leu Glu Ala Leu Ser Val His Val Ser Ser Glu Arg 
        915                 920                 925             


Ser Leu Pro Glu Glu Glu Trp Arg Ala Val Ile Gly Asp Ile Tyr Gln 
    930                 935                 940                 


Cys Lys Leu Cys Asn Tyr Asn Thr Gln Leu Lys Ala Asn Phe Gln Leu 
945                 950                 955                 960 


His Cys Lys Thr Asp Lys His Met Gln Lys Tyr Gln Leu Val Ala His 
                965                 970                 975     


Ile Lys Glu Gly Gly Lys Ser Asn Glu Trp Arg Leu Lys Cys Ile Ala 
            980                 985                 990         


Ile Gly Asn Pro Val His Leu Lys  Cys Asn Ala Cys Asp  Tyr Tyr Thr 
        995                 1000                 1005             


Asn Ser  Val Asp Lys Leu Arg  Leu His Thr Thr Asn  His Arg His 
    1010                 1015                 1020             


Glu Ala  Ala Leu Lys Leu Tyr  Lys His Leu Gln Lys  Gln Glu Gly 
    1025                 1030                 1035             


Ala Val  Asn Pro Glu Ser Cys  Tyr Tyr Tyr Cys Ala  Val Cys Asp 
    1040                 1045                 1050             


Tyr Thr  Thr Lys Val Lys Leu  Asn Leu Val Gln His  Val Arg Ser 
    1055                 1060                 1065             


Val Lys  His Gln Gln Thr Glu  Gly Leu Arg Lys Leu  Gln Leu His 
    1070                 1075                 1080             


Gln Gln  Gly Leu Ala Pro Glu  Glu Asp Asn Leu Ser  Glu Ile Phe 
    1085                 1090                 1095             


Phe Val  Lys Asp Cys Pro Pro  Asn Glu Leu Glu Thr  Ala Ser Leu 
    1100                 1105                 1110             


Gly Ala  Arg Thr Cys Asp Asp  Asp Leu Thr Glu Gln  Gln Leu Arg 
    1115                 1120                 1125             


Ser Thr  Ser Glu Glu Gln Ser  Glu Glu Ala Glu Gly  Ala Ile Lys 
    1130                 1135                 1140             


Pro Thr  Ala Val Ala Glu Asp  Asp Glu Lys Asp Thr  Ser Glu Arg 
    1145                 1150                 1155             


Asp Asn  Ser Glu Gly Lys Asn  Ser Asn Lys Asp Ser  Gly Ile Ile 
    1160                 1165                 1170             


Thr Pro  Glu Lys Glu Leu Lys  Val Ser Val Ala Gly  Gly Thr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Leu Ala Lys Glu  Glu Asp Val Ala Thr  Lys Arg Ser 
    1190                 1195                 1200             


Lys Pro  Thr Glu Asp Asn Lys  Phe Cys His Glu Gln  Phe Tyr Gln 
    1205                 1210                 1215             


Cys Pro  Tyr Cys Asn Tyr Asn  Ser Arg Asp Gln Ser  Arg Ile Gln 
    1220                 1225                 1230             


Met His  Val Leu Ser Gln His  Ser Val Gln Pro Val  Ile Cys Cys 
    1235                 1240                 1245             


Pro Leu  Cys Gln Asp Val Leu  Ser Asn Lys Met His  Leu Gln Leu 
    1250                 1255                 1260             


His Leu  Thr His Leu His Ser  Val Ser Pro Asp Cys  Val Glu Lys 
    1265                 1270                 1275             


Leu Leu  Met Thr Val Pro Val  Pro Asp Val Met Met  Pro Asn Ser 
    1280                 1285                 1290             


Met Leu  Leu Pro Ala Ala Ala  Ser Glu Lys Ser Glu  Arg Asp Thr 
    1295                 1300                 1305             


Pro Ala  Ala Val Thr Ala Glu  Gly Ser Gly Lys Tyr  Ser Gly Glu 
    1310                 1315                 1320             


Ser Pro  Met Asp Asp Lys Ser  Met Ala Gly Leu Glu  Asp Ser Lys 
    1325                 1330                 1335             


Ala Asn  Val Glu Val Lys Asn  Glu Glu Gln Lys Pro  Thr Lys Glu 
    1340                 1345                 1350             


Pro Leu  Glu Val Ser Glu Trp  Asn Lys Asn Ser Ser  Lys Asp Val 
    1355                 1360                 1365             


Lys Ile  Pro Asp Thr Leu Gln  Asp Gln Leu Asn Glu  Gln Gln Lys 
    1370                 1375                 1380             


Arg Gln  Pro Leu Ser Val Ser  Asp Arg His Val Tyr  Lys Tyr Arg 
    1385                 1390                 1395             


Cys Asn  His Cys Ser Leu Ala  Phe Lys Thr Met Gln  Lys Leu Gln 
    1400                 1405                 1410             


Ile His  Ser Gln Tyr His Ala  Ile Arg Ala Ala Thr  Met Cys Asn 
    1415                 1420                 1425             


Leu Cys  Gln Arg Ser Phe Arg  Thr Phe Gln Ala Leu  Lys Lys His 
    1430                 1435                 1440             


Leu Glu  Ala Gly His Pro Glu  Leu Ser Glu Ala Glu  Leu Gln Gln 
    1445                 1450                 1455             


Leu Tyr  Ala Ser Leu Pro Val  Asn Gly Glu Leu Trp  Ala Glu Ser 
    1460                 1465                 1470             


Glu Thr  Met Ser Gln Asp Asp  His Gly Leu Glu Gln  Glu Met Glu 
    1475                 1480                 1485             


Arg Glu  Tyr Glu Val Asp His  Glu Gly Lys Ala Ser  Pro Val Gly 
    1490                 1495                 1500             


Ser Asp  Ser Ser Ser Ile Pro  Asp Asp Met Gly Ser  Glu Pro Lys 
    1505                 1510                 1515             


Arg Thr  Leu Pro Phe Arg Lys  Gly Pro Asn Phe Thr  Met Glu Lys 
    1520                 1525                 1530             


Phe Leu  Asp Pro Ser Arg Pro  Tyr Lys Cys Thr Val  Cys Lys Glu 
    1535                 1540                 1545             


Ser Phe  Thr Gln Lys Asn Ile  Leu Leu Val His Tyr  Asn Ser Val 
    1550                 1555                 1560             


Ser His  Leu His Lys Leu Lys  Lys Val Leu Gln Glu  Ala Ser Ser 
    1565                 1570                 1575             


Pro Val  Pro Gln Glu Thr Asn  Ser Asn Thr Asp Asn  Lys Pro Tyr 
    1580                 1585                 1590             


Lys Cys  Ser Ile Cys Asn Val  Ala Tyr Ser Gln Ser  Ser Thr Leu 
    1595                 1600                 1605             


Glu Ile  His Met Arg Ser Val  Leu His Gln Thr Lys  Ala Arg Ala 
    1610                 1615                 1620             


Ala Lys  Leu Glu Pro Ser Gly  His Val Ala Gly Gly  His Ser Ile 
    1625                 1630                 1635             


Ala Ala  Asn Val Asn Ser Pro  Gly Gln Gly Met Leu  Asp Ser Met 
    1640                 1645                 1650             


Ser Leu  Ala Ala Val Asn Ser  Lys Asp Thr His Leu  Asp Ala Lys 
    1655                 1660                 1665             


Glu Leu  Asn Lys Lys Gln Thr  Pro Asp Leu Ile Ser  Ala Gln Pro 
    1670                 1675                 1680             


Ala His  His Pro Pro Gln Ser  Pro Ala Gln Ile Gln  Met Gln Leu 
    1685                 1690                 1695             


Gln His  Glu Leu Gln Gln Gln  Ala Ala Phe Phe Gln  Pro Gln Phe 
    1700                 1705                 1710             


Leu Asn  Pro Ala Phe Leu Pro  His Phe Pro Met Thr  Pro Glu Ala 
    1715                 1720                 1725             


Leu Leu  Gln Phe Gln Gln Pro  Gln Phe Leu Phe Pro  Phe Tyr Ile 
    1730                 1735                 1740             


Pro Gly  Thr Glu Phe Ser Leu  Gly Pro Asp Leu Gly  Leu Pro Gly 
    1745                 1750                 1755             


Ser Ala  Thr Phe Gly Met Pro  Gly Met Thr Gly Met  Ala Gly Ser 
    1760                 1765                 1770             


Leu Leu  Glu Asp Leu Lys Gln  Gln Ile Gln Thr Gln  His His Val 
    1775                 1780                 1785             


Gly Gln  Thr Gln Leu Gln Ile  Leu Gln Gln Gln Ala  Gln Gln Tyr 
    1790                 1795                 1800             


Gln Ala  Thr Gln Pro Gln Leu  Gln Pro Gln Lys Gln  Gln Gln Gln 
    1805                 1810                 1815             


Pro Pro  Pro Pro Gln Gln Gln  Gln Gln Gln Gln Ala  Ser Lys Leu 
    1820                 1825                 1830             


Leu Lys  Gln Glu Gln Ser Asn  Ile Val Ser Ala Asp  Cys Gln Ile 
    1835                 1840                 1845             


Met Lys  Asp Val Pro Ser Tyr  Lys Glu Ala Glu Asp  Ile Ser Glu 
    1850                 1855                 1860             


Lys Pro  Glu Lys Pro Lys Gln  Glu Phe Ile Ser Glu  Gly Glu Gly 
    1865                 1870                 1875             


Leu Lys  Glu Gly Lys Asp Thr  Lys Lys Gln Lys Ser  Leu Glu Pro 
    1880                 1885                 1890             


Ser Ile  Pro Pro Pro Arg Ile  Ala Ser Gly Ala Arg  Gly Asn Ala 
    1895                 1900                 1905             


Ala Lys  Ala Leu Leu Glu Asn  Phe Gly Phe Glu Leu  Val Ile Gln 
    1910                 1915                 1920             


Tyr Asn  Glu Asn Arg Gln Lys  Val Gln Lys Lys Gly  Lys Ser Gly 
    1925                 1930                 1935             


Glu Gly  Glu Asn Thr Asp Lys  Leu Glu Cys Gly Thr  Cys Gly Lys 
    1940                 1945                 1950             


Leu Phe  Ser Asn Val Leu Ile  Leu Lys Ser His Gln  Glu His Val 
    1955                 1960                 1965             


His Gly  Gln Phe Phe Pro Tyr  Ala Ala Leu Glu Lys  Phe Ala Arg 
    1970                 1975                 1980             


Gln Tyr  Arg Glu Ala Tyr Asp  Lys Leu Tyr Pro Ile  Ser Pro Ser 
    1985                 1990                 1995             


Ser Pro  Glu Thr Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Leu Pro 
    2000                 2005                 2010             


Pro Ala  Pro Pro Gln Pro Ser  Ser Met Gly Pro Val  Lys Ile Pro 
    2015                 2020                 2025             


Asn Thr  Val Ser Thr Pro Leu  Gln Ala Pro Pro Pro  Thr Pro Pro 
    2030                 2035                 2040             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    2045                 2050                 2055             


Pro Pro  Pro Ser Ala Pro Pro  Gln Val Gln Leu Pro  Val Ser Leu 
    2060                 2065                 2070             


Asp Leu  Pro Leu Phe Pro Ser  Ile Met Met Gln Pro  Val Gln His 
    2075                 2080                 2085             


Pro Ala  Leu Pro Pro Gln Leu  Ala Leu Gln Leu Pro  Gln Met Asp 
    2090                 2095                 2100             


Ala Leu  Ser Ala Asp Leu Thr  Gln Leu Cys Gln Gln  Gln Leu Gly 
    2105                 2110                 2115             


Leu Asp  Pro Asn Phe Leu Arg  His Ser Gln Phe Lys  Arg Pro Arg 
    2120                 2125                 2130             


Thr Arg  Ile Thr Asp Asp Gln  Leu Lys Ile Leu Arg  Ala Tyr Phe 
    2135                 2140                 2145             


Asp Ile  Asn Asn Ser Pro Ser  Glu Glu Gln Ile Gln  Glu Met Ala 
    2150                 2155                 2160             


Glu Lys  Ser Gly Leu Ser Gln  Lys Val Ile Lys His  Trp Phe Arg 
    2165                 2170                 2175             


Asn Thr  Leu Phe Lys Glu Arg  Gln Arg Asn Lys Asp  Ser Pro Tyr 
    2180                 2185                 2190             


Asn Phe  Ser Asn Pro Pro Ile  Thr Val Leu Glu Asp  Ile Arg Ile 
    2195                 2200                 2205             


Asp Pro  Gln Pro Thr Ser Leu  Glu His Tyr Lys Ser  Asp Ala Ser 
    2210                 2215                 2220             


Phe Ser  Lys Arg Ser Ser Arg  Thr Arg Phe Thr Asp  Tyr Gln Leu 
    2225                 2230                 2235             


Arg Val  Leu Gln Asp Phe Phe  Asp Thr Asn Ala Tyr  Pro Lys Asp 
    2240                 2245                 2250             


Asp Glu  Ile Glu Gln Leu Ser  Thr Val Leu Asn Leu  Pro Thr Arg 
    2255                 2260                 2265             


Val Ile  Val Val Trp Phe Gln  Asn Ala Arg Gln Lys  Ala Arg Lys 
    2270                 2275                 2280             


Ser Tyr  Glu Asn Gln Ala Glu  Thr Lys Asp Asn Glu  Lys Arg Glu 
    2285                 2290                 2295             


Leu Thr  Asn Glu Arg Tyr Ile  Arg Thr Ser Asn Met  Gln Tyr Gln 
    2300                 2305                 2310             


Cys Lys  Lys Cys Asn Val Val  Phe Pro Arg Ile Phe  Asp Leu Ile 
    2315                 2320                 2325             


Thr His  Gln Lys Lys Gln Cys  Tyr Lys Asp Glu Asp  Asp Asp Ala 
    2330                 2335                 2340             


Gln Asp  Glu Ser Gln Thr Glu  Asp Ser Met Asp Ala  Thr Asp Gln 
    2345                 2350                 2355             


Val Val  Tyr Lys His Cys Thr  Val Ser Gly Gln Thr  Asp Ala Ala 
    2360                 2365                 2370             


Lys Asn  Ala Ala Ala Pro Ala  Ala Ser Ser Gly Ser  Gly Thr Ser 
    2375                 2380                 2385             


Thr Pro  Leu Ile Pro Ser Pro  Lys Pro Glu Pro Glu  Lys Thr Ser 
    2390                 2395                 2400             


Pro Lys  Pro Glu Tyr Pro Ala  Glu Lys Pro Lys Gln  Ser Asp Pro 
    2405                 2410                 2415             


Ser Pro  Pro Ser Gln Gly Thr  Lys Pro Ala Leu Pro  Leu Ala Ser 
    2420                 2425                 2430             


Thr Ser  Ser Asp Pro Pro Gln  Ala Ser Thr Ala Gln  Pro Gln Pro 
    2435                 2440                 2445             


Gln Pro  Gln Pro Pro Lys Gln  Pro Gln Leu Ile Gly  Arg Pro Pro 
    2450                 2455                 2460             


Ser Ala  Ser Gln Thr Pro Val  Pro Ser Ser Pro Leu  Gln Ile Ser 
    2465                 2470                 2475             


Met Thr  Ser Leu Gln Asn Ser  Leu Pro Pro Gln Leu  Leu Gln Tyr 
    2480                 2485                 2490             


Gln Cys  Asp Gln Cys Thr Val  Ala Phe Pro Thr Leu  Glu Leu Trp 
    2495                 2500                 2505             


Gln Glu  His Gln His Met His  Phe Leu Ala Ala Gln  Asn Gln Phe 
    2510                 2515                 2520             


Leu His  Ser Pro Phe Leu Glu  Arg Pro Met Asp Met  Pro Tyr Met 
    2525                 2530                 2535             


Ile Phe  Asp Pro Asn Asn Pro  Leu Met Thr Gly Gln  Leu Leu Gly 
    2540                 2545                 2550             


Ser Ser  Leu Thr Gln Met Pro  Pro Gln Ala Ser Ser  Ser His Thr 
    2555                 2560                 2565             


Thr Ala  Pro Thr Thr Val Ala  Ala Ser Leu Lys Arg  Lys Leu Asp 
    2570                 2575                 2580             


Asp Lys  Glu Asp Asn Asn Cys  Ser Glu Lys Glu Gly  Gly Asn Ser 
    2585                 2590                 2595             


Gly Glu  Asp Gln His Arg Asp  Lys Arg Leu Arg Thr  Thr Ile Thr 
    2600                 2605                 2610             


Pro Glu  Gln Leu Glu Ile Leu  Tyr Glu Lys Tyr Leu  Leu Asp Ser 
    2615                 2620                 2625             


Asn Pro  Thr Arg Lys Met Leu  Asp His Ile Ala Arg  Glu Val Gly 
    2630                 2635                 2640             


Leu Lys  Lys Arg Val Val Gln  Val Trp Phe Gln Asn  Thr Arg Ala 
    2645                 2650                 2655             


Arg Glu  Arg Lys Gly Gln Phe  Arg Ala Val Gly Pro  Ala Gln Ser 
    2660                 2665                 2670             


His Lys  Arg Cys Pro Phe Cys  Arg Ala Leu Phe Lys  Ala Lys Ser 
    2675                 2680                 2685             


Ala Leu  Glu Ser His Ile Arg  Ser Arg His Trp Asn  Glu Gly Lys 
    2690                 2695                 2700             


Gln Ala  Gly Tyr Ser Leu Pro  Pro Ser Pro Leu Ile  Ser Thr Glu 
    2705                 2710                 2715             


Asp Gly  Gly Glu Ser Pro Gln  Lys Tyr Ile Tyr Phe  Asp Tyr Pro 
    2720                 2725                 2730             


Ser Leu  Pro Leu Thr Lys Ile  Asp Leu Ser Ser Glu  Asn Glu Leu 
    2735                 2740                 2745             


Ala Ser  Thr Val Ser Thr Pro  Val Ser Lys Thr Ala  Glu Leu Ser 
    2750                 2755                 2760             


Pro Lys  Asn Leu Leu Ser Pro  Ser Ser Phe Lys Ala  Glu Cys Ser 
    2765                 2770                 2775             


Glu Asp  Val Glu Asn Leu Asn  Ala Pro Pro Ala Glu  Ala Gly Tyr 
    2780                 2785                 2790             


Asp Gln  Asn Lys Thr Asp Phe  Asp Glu Thr Ser Ser  Ile Asn Thr 
    2795                 2800                 2805             


Ala Ile  Ser Asp Ala Thr Thr  Gly Asp Glu Gly Asn  Thr Glu Met 
    2810                 2815                 2820             


Glu Ser  Thr Thr Gly Ser Ser  Gly Asp Val Lys Pro  Ala Leu Ser 
    2825                 2830                 2835             


Pro Lys  Glu Pro Lys Thr Leu  Asp Thr Leu Pro Lys  Pro Ala Thr 
    2840                 2845                 2850             


Thr Pro  Thr Thr Glu Val Cys  Asp Asp Lys Phe Leu  Phe Ser Leu 
    2855                 2860                 2865             


Thr Ser  Pro Ser Ile His Phe  Asn Asp Lys Asp Gly  Asp His Asp 
    2870                 2875                 2880             


Gln Ser  Phe Tyr Ile Thr Asp  Asp Pro Asp Asp Asn  Ala Asp Arg 
    2885                 2890                 2895             


Ser Glu  Thr Ser Ser Ile Ala  Asp Pro Ser Ser Pro  Asn Pro Phe 
    2900                 2905                 2910             


Gly Ser  Ser Asn Pro Phe Lys  Ser Lys Ser Asn Asp  Arg Pro Gly 
    2915                 2920                 2925             


His Lys  Arg Phe Arg Thr Gln  Met Ser Asn Leu Gln  Leu Lys Val 
    2930                 2935                 2940             


Leu Lys  Ala Cys Phe Ser Asp  Tyr Arg Thr Pro Thr  Met Gln Glu 
    2945                 2950                 2955             


Cys Glu  Met Leu Gly Asn Glu  Ile Gly Leu Pro Lys  Arg Val Val 
    2960                 2965                 2970             


Gln Val  Trp Phe Gln Asn Ala  Arg Ala Lys Glu Lys  Lys Phe Lys 
    2975                 2980                 2985             


Ile Asn  Ile Gly Lys Pro Phe  Met Ile Asn Gln Gly  Gly Thr Glu 
    2990                 2995                 3000             


Gly Thr  Lys Pro Glu Cys Thr  Leu Cys Gly Val Lys  Tyr Ser Ala 
    3005                 3010                 3015             


Arg Leu  Ser Ile Arg Asp His  Ile Phe Ser Lys Gln  His Ile Ser 
    3020                 3025                 3030             


Lys Val  Arg Glu Thr Val Gly  Ser Gln Leu Asp Arg  Glu Lys Asp 
    3035                 3040                 3045             


Tyr Leu  Ala Pro Thr Thr Val  Arg Gln Leu Met Ala  Gln Gln Glu 
    3050                 3055                 3060             


Leu Asp  Arg Ile Lys Lys Ala  Ser Asp Val Leu Gly  Leu Thr Val 
    3065                 3070                 3075             


Gln Gln  Pro Gly Met Met Asp  Ser Ser Ser Leu His  Gly Ile Ser 
    3080                 3085                 3090             


Leu Pro  Thr Ala Tyr Pro Gly  Leu Pro Gly Leu Pro  Pro Val Leu 
    3095                 3100                 3105             


Leu Pro  Gly Met Asn Gly Pro  Ser Ser Leu Pro Gly  Phe Pro Gln 
    3110                 3115                 3120             


Asn Ser  Asn Thr Leu Thr Pro  Pro Gly Ala Gly Met  Leu Gly Phe 
    3125                 3130                 3135             


Pro Thr  Ser Ala Thr Ser Ser  Pro Ala Leu Ser Leu  Ser Ser Ala 
    3140                 3145                 3150             


Pro Thr  Lys Pro Leu Leu Gln  Thr Pro Pro Pro Pro  Pro Pro Pro 
    3155                 3160                 3165             


Pro Pro  Pro Pro Pro Ser Ser  Ser Leu Ser Gly Gln  Gln Thr Glu 
    3170                 3175                 3180             


Gln Gln  Asn Lys Glu Ser Glu  Lys Lys Gln Thr Lys  Pro Asn Lys 
    3185                 3190                 3195             


Val Lys  Lys Ile Lys Glu Glu  Glu Leu Glu Ala Thr  Lys Pro Glu 
    3200                 3205                 3210             


Lys His  Pro Lys Lys Glu Glu  Lys Ile Ser Ser Ala  Leu Ser Val 
    3215                 3220                 3225             


Leu Gly  Lys Val Val Gly Glu  Thr His Val Asp Pro  Ile Gln Leu 
    3230                 3235                 3240             


Gln Ala  Leu Gln Asn Ala Ile  Ala Gly Asp Pro Ala  Ser Phe Ile 
    3245                 3250                 3255             


Gly Gly  Gln Phe Leu Pro Tyr  Phe Ile Pro Gly Phe  Ala Ser Tyr 
    3260                 3265                 3270             


Phe Thr  Pro Gln Leu Pro Gly  Thr Val Gln Gly Gly  Tyr Phe Pro 
    3275                 3280                 3285             


Pro Val  Cys Gly Met Glu Ser  Leu Phe Pro Tyr Gly  Pro Thr Met 
    3290                 3295                 3300             


Pro Gln  Thr Leu Ala Gly Leu  Ser Pro Gly Ala Leu  Leu Gln Gln 
    3305                 3310                 3315             


Tyr Gln  Gln Tyr Gln Gln Asn  Leu Gln Glu Ser Leu  Gln Lys Gln 
    3320                 3325                 3330             


Gln Lys  Gln Gln Gln Glu Gln  Gln Gln Lys Pro Val  Gln Ala Lys 
    3335                 3340                 3345             


Thr Ser  Lys Val Glu Ser Asp  Gln Pro Gln Asn Ser  Asn Asp Ala 
    3350                 3355                 3360             


Ser Glu  Thr Lys Glu Asp Lys  Ser Thr Ala Thr Glu  Ser Thr Lys 
    3365                 3370                 3375             


Glu Glu  Pro Gln Leu Glu Ser  Lys Ser Ala Asp Phe  Ser Asp Thr 
    3380                 3385                 3390             


Tyr Val  Val Pro Phe Val Lys  Tyr Glu Phe Ile Cys  Arg Lys Cys 
    3395                 3400                 3405             


Gln Met  Met Phe Thr Asp Glu  Asp Ala Ala Val Asn  His Gln Lys 
    3410                 3415                 3420             


Ser Phe  Cys Tyr Phe Gly Gln  Pro Leu Ile Asp Pro  Gln Glu Thr 
    3425                 3430                 3435             


Val Leu  Arg Val Pro Val Ser  Lys Tyr Gln Cys Leu  Ala Cys Asp 
    3440                 3445                 3450             


Val Ala  Ile Ser Gly Asn Glu  Ala Leu Ser Gln His  Leu Gln Ser 
    3455                 3460                 3465             


Ser Leu  His Lys Glu Lys Thr  Ile Lys Gln Ala Met  Arg Asn Ala 
    3470                 3475                 3480             


Lys Glu  His Val Arg Leu Leu  Pro His Ser Val Cys  Ser Pro Asn 
    3485                 3490                 3495             


Pro Asn  Thr Thr Ser Thr Ser  Gln Ser Ala Ala Ser  Ser Asn Asn 
    3500                 3505                 3510             


Thr Tyr  Pro His Leu Ser Cys  Phe Ser Met Lys Ser  Trp Pro Asn 
    3515                 3520                 3525             


Ile Leu  Phe Gln Ala Ser Ala  Arg Arg Ala Ala Ser  Pro Pro Ser 
    3530                 3535                 3540             


Ser Pro  Pro Ser Leu Ser Leu  Pro Ser Thr Val Thr  Ser Ser Leu 
    3545                 3550                 3555             


Cys Ser  Thr Ser Gly Val Gln  Thr Ser Leu Pro Thr  Glu Ser Cys 
    3560                 3565                 3570             


Ser Asp  Glu Ser Asp Ser Glu  Leu Ser Gln Lys Leu  Glu Asp Leu 
    3575                 3580                 3585             


Asp Asn  Ser Leu Glu Val Lys  Ala Lys Pro Ala Ser  Gly Leu Asp 
    3590                 3595                 3600             


Gly Asn  Phe Asn Ser Ile Arg  Met Asp Met Phe Ser  Val 
    3605                 3610                 3615     


<210>  20
<211>  13975
<212>  DNA
<213>  Homo sapiens

<400>  20
atttttttaa acagggctaa aacgataata attagcagaa taaagacata tcggattttc       60

atttcctttc ctccttttcc caaccccttc acaaccaaac agcgagaccg cggtcggcac      120

atgctttaac tcctcccgga cccccgagga ccgctccatg ccccccactt tctgctccag      180

cgtttttatt ttcacccaat aaagttcgag gattattttt tatttttttt gtttttttaa      240

tgaaccctct cgttttactt ggatgtgatc agctgtaagt aaaataaaag caaaacaaaa      300

aagaggcgaa gatcgagtag gaactgcagg ggaaatggaa agtccctgac aggctggatg      360

aaatgagatc cccatgtagc aattgccatg gaaacctgtg actcccctcc tatctcaagg      420

caggaaaatg ggcagagcac atcaaagcta tgtggaacga cacaacttga taatgaggtg      480

ccagagaaag ttgcagggat ggagcctgac agggaaaaca gctccacaga tgacaacctg      540

aaaacggatg agcgcaaaag tgaagccttg ctgggtttca gcgttgagaa tgcagctgcc      600

actcaggtta cctcagcaaa ggagataccc tgcaacgaat gtgccacttc ttttcccagt      660

ttacagaaat acatggaaca ccactgccct aatgcccgcc ttcctgtcct gaaggatgac      720

aacgagagcg agatcagcga gttagaggac agtgacgtgg aaaatctaac aggggagatc      780

gtttaccagc ctgatgggtc agcatatata attgaggact ccaaagaaag tgggcagaat      840

gcacagactg gggcaaatag caaactcttt tctacagcga tgttcctgga ctccctggca      900

tctgctggag agaagagtga tcagtctgct tctgcaccta tgtcgttcta cccacagatc      960

atcaacactt ttcatatcgc ttcatccctc gggaaaccat ttacagccga tcaggctttc     1020

ccaaatacct cagcattagc aggagttggt cctgtgttgc acagtttccg tgtctatgat     1080

ctccgacaca agagagagaa agactatcta accagtgatg gctcagccaa aaactcctgt     1140

gtgtccaaag atgtccctaa caatgtggac ttgtccaaat tcgatggttg tgttagcgat     1200

gggaaaagga aacctgtttt aatgtgtttc ttgtgcaagt tgtcttttgg ttatatcagg     1260

tcatttgtaa cccatgctgt gcatgatcat cggatgaccc tcaatgacga ggagcagaag     1320

ctcctcagta ataaatgcgt ctccgccata atacagggga ttggcaaaga caaagaacct     1380

cttataagct ttctggaacc aaaaaaatcc acttctgttt atccccattt ttctactaca     1440

aacctcatag gacccgatcc aaccttccgc ggtttatgga gcgcttttca tgttgaaaat     1500

ggtgactctt tgccggctgg ctttgccttc ttaaaaggaa gcgcgagcac ctcgagctca     1560

gcagagcagc cgctggggat tacccaaatg ccaaaggctg aagtgaatct gggggggctg     1620

tctagtttag tagtgaacac cccaattacc tctgtctccc tcagccactc atcgtctgag     1680

tctagcaaga tgtcagagag caaagaccaa gagaacaact gtgaaaggcc aaaagaaagc     1740

aacgttttac acccaaacgg ggagtgccct gtcaaaagtg aacccactga accgggagat     1800

gaggatgaag aagatgcgta ctccaatgaa cttgatgacg aggaagtatt aggtgaactc     1860

accgatagta ttggtaacaa agatttccct ctcttaaacc aaagcatttc tcctttatca     1920

tccagtgtgc taaaatttat tgaaaagggt acctcgtcct cctcggcgac tgtttctgat     1980

gacacagaaa agaaaaaaca gactgctgct gttagggcca gtggcagtgt tgctagtaac     2040

tatggcatca gtggcaagga ctttgcagac gcaagtgcca gtaaagacag tgccacagct     2100

gctcatccaa gtgaaatagc ccggggagac gaagacagtt cagccactcc tcaccagcat     2160

ggctttaccc cgagtactcc tggcacacca gggcctggag gagacggctc accgggcagt     2220

ggcatcgagt gtccaaagtg cgacactgtg ttggggtctt cgaggtctct tggtggtcat     2280

atgactatga tgcactcgag gaactcatgc aaaaccctca aatgtcctaa atgtaactgg     2340

cactacaaat atcagcagac cctggaggcc catatgaagg agaaacaccc tgagccgggt     2400

ggctcttgtg tttattgtaa gactggacag cctcacccca ggcttgcccg gggtgagagt     2460

tacacgtgtg gctataaacc cttccgttgt gaggtttgta actactctac cactaccaaa     2520

ggcaacctca gtattcatat gcagtcggac aagcacctga acaatgttca gaatctccaa     2580

aatggcaatg gtgagcaggt gtttggccac tctgccccag cccccaacac cagcctcagt     2640

ggctgcggaa caccctctcc gtccaaaccc aaacagaaac ccacctggcg gtgtgaagtt     2700

tgtgattatg aaaccaatgt cgccaggaac ctccgaattc atatgaccag cgaaaagcac     2760

atgcataata tgatgctttt gcagcagaac atgaagcaga tccagcataa tctgcacttg     2820

ggcctcgccc cggcggaagc agagctttat cagtactacc tagcccagaa cataggcctg     2880

accggaatga agctggaaaa ccctgccgac cctcagctga tgatcaatcc attccagctg     2940

gatccagcga cagcagcggc tttggcacca gggctcgtaa ataatgagct gccgcctgaa     3000

atccggcttg ccagtggtca gctaatgggt gatgacctgt ccctccttac tgcaggagag     3060

ctgtcacctt atatcagtga cccagcgctg aagctattcc agtgtgctgt ttgcaacaaa     3120

ttcacctctg acagcctgga ggccctaagt gtgcatgtga gcagtgagcg ctctctccct     3180

gaagaggaat ggagggcagt aattggagat atctaccagt gcaagctctg caactacaac     3240

actcagctca aagccaactt ccagctacac tgcaagactg ataaacatat gcagaaatat     3300

caactggtgg ctcacattaa agaagggggc aaaagcaatg agtggaggtt gaagtgtatt     3360

gccattggca accctgttca cctaaaatgt aacgcctgtg actattacac caacagtgtg     3420

gataaattac gcttgcatac caccaatcac aggcacgagg cggccctgaa gctctacaag     3480

cacttgcaga agcaagaggg tgcagtgaat cccgaatcct gctattacta ctgtgccgtg     3540

tgtgattaca ccaccaaggt caagttgaat ctggtacaac atgtccgttc ggtgaagcat     3600

cagcagactg agggcctacg gaagctccag ctccaccagc aaggcctggc accagaggag     3660

gacaacctca gtgagatctt ttttgttaaa gattgcccac caaatgagct tgaaactgcc     3720

tcattgggag ccaggacttg tgatgatgat cttacagagc agcagttgag atcgacctca     3780

gaagaacaaa gtgaggaggc agaaggagct attaagccta cagcagtggc cgaggacgat     3840

gaaaaagaca caagtgagag agacaatagt gaaggcaaaa actctaataa agactctggg     3900

ataatcacac cagagaagga actaaaagtt agtgtggcag ggggtaccca gccactcctg     3960

ctggcaaaag aagaggatgt tgcaacaaaa aggtcaaaac ctacagagga caataaattc     4020

tgtcatgaac agttctatca atgtccttat tgtaactaca atagtaggga ccaaagtcgt     4080

atccagatgc acgtcctatc acagcactcg gtgcagccgg tcatctgctg tcctctctgt     4140

caggacgtcc tcagcaacaa aatgcatctc caactgcatc tgacgcattt gcacagtgtg     4200

tctccagact gtgtggagaa gctgcttatg acagtgcctg tccctgatgt gatgatgcca     4260

aacagtatgc tactgccagc agctgcctct gagaaatcag agcgggacac acctgcagcc     4320

gtgacagctg aggggtctgg gaaatattca ggtgaaagtc caatggatga caaaagcatg     4380

gcaggtctcg aggattcaaa ggctaatgtg gaagtaaaga atgaggagca gaaaccgact     4440

aaagaaccct tggaagtctc agaatggaat aaaaatagca gtaaggatgt gaaaatcccc     4500

gacacactgc aagatcaatt aaatgaacag caaaaaaggc aaccgctctc tgtttctgac     4560

cgtcatgtct acaagtatcg ctgtaaccat tgtagcttgg ctttcaaaac tatgcagaag     4620

cttcagatac attcccagta tcatgcaatt cgggctgcga caatgtgtaa cctctgccag     4680

cgcagtttcc gtacattcca ggctttaaaa aaacacttgg aagcaggcca ccctgaactg     4740

agtgaagctg aacttcaaca gctatatgcc tccttgcccg tgaatggaga actgtgggca     4800

gagagcgaaa ctatgtccca ggatgaccat ggcctagagc aggaaatgga gagagagtat     4860

gaggtggacc acgaagggaa agcaagtcct gtaggaagtg atagtagctc tattccagat     4920

gacatgggct ctgaaccaaa gcggacctta ccttttagaa aagggcccaa ttttacgatg     4980

gaaaaattcc ttgatccatc tcgtccatat aaatgtacag tgtgtaaaga gtcattcacc     5040

caaaagaaca ttctcttggt ccactataat tcagtttctc acttgcataa gctgaaaaaa     5100

gttttgcagg aagcctccag tcctgtccca caagaaacca acagcaacac agataacaaa     5160

ccctacaagt gcagcatctg caatgttgca tacagccaaa gctcaacatt ggaaatccac     5220

atgaggtctg tgctccacca gacaaaggct agggctgcaa agctggagcc cagtggtcat     5280

gtggctggtg ggcacagcat tgcagcaaat gtcaacagcc ctggccaggg gatgttagat     5340

tccatgagtt tagcagctgt aaacagcaaa gatacccatt tagatgccaa agaattaaat     5400

aaaaagcaaa ctcctgattt aatctctgct caacctgcac atcacccacc acagtcacca     5460

gcacaaattc agatgcaact acagcacgaa ttacaacagc aagccgcatt ctttcagcct     5520

cagtttctaa acccagcctt tttgcctcat tttcctatga ccccagaagc actgctgcag     5580

tttcagcagc ctcagtttct ctttccattt tatatacctg ggacggagtt cagcttgggg     5640

ccagatttgg gcttgccagg ctctgccaca tttgggatgc ctggcatgac aggaatggct     5700

ggctccttgc ttgaagacct aaagcagcag attcaaaccc aacatcacgt tggtcaaact     5760

caactccaga tactacagca acaagcacaa caataccaag ccacacagcc ccagctgcag     5820

cctcaaaaac aacagcagca gccaccacct ccacagcagc agcagcaaca gcaggcaagc     5880

aaattattga aacaagagca aagtaacata gtgagtgcag actgccaaat catgaaggat     5940

gtgccatctt ataaggaggc agaagatatt tctgaaaagc cagaaaaacc aaagcaggaa     6000

tttataagtg aaggtgaagg actcaaagaa ggcaaagaca caaagaagca aaaatccttg     6060

gaaccatcca tcccaccacc ccgaatagct tcaggggcca gaggaaatgc tgccaaagcg     6120

ttattggaaa actttggttt tgaactggtc attcagtata acgaaaacag gcagaaggta     6180

cagaagaagg gcaaaagtgg tgaaggcgaa aacactgaca aactagaatg tggaacatgt     6240

ggtaaattgt tttccaatgt tcttatttta aagagtcacc aagaacatgt acatgggcaa     6300

ttttttccat atgcagcgct agaaaaattt gctcgtcaat acagggaggc ctatgacaag     6360

ctttatccaa tttctccatc ttctccagaa acgccgcccc cgccacctcc tcctcctccc     6420

ttgcctccgg ctcctccaca gccttcttct atgggtcctg taaagatccc caacacggtt     6480

tctactcctc tgcaagctcc accacccact cctcccccac caccaccacc tcctcctcct     6540

cctcctcctc cccccccacc tcctccacct tctgctcctc cacaggtcca actgccggtt     6600

tctctggacc tgccgctctt tccttccatt atgatgcaac ctgtgcaaca ccctgcgctt     6660

cctccccagc ttgccctgca gctgccacag atggacgcac tctctgcaga cctcacccaa     6720

ctttgccagc agcagctcgg attagatccc aacttcttaa gacattctca gttcaaacgc     6780

ccacggacaa gaattacaga tgatcagcta aaaatcctga gggcttattt tgacattaat     6840

aattctccaa gtgaagaaca gatccaggaa atggcagaga aatctggcct ctcccaaaaa     6900

gttatcaaac actggtttag aaatacgctt tttaaggaac gacagagaaa taaagattca     6960

ccatacaact tcagtaaccc tcctataacg gttttagaag atatcagaat tgatccacag     7020

cccacctctt tagaacatta caaatctgat gcatcattca gtaaaaggtc ttctagaacg     7080

agatttactg actaccagct tagggttctg caagactttt ttgacacaaa cgcttaccca     7140

aaagatgatg aaatagaaca actctccact gttctcaatc tgcctacccg ggttattgtt     7200

gtatggttcc agaatgctcg tcagaaagca cgaaagagtt atgagaatca agcagaaaca     7260

aaagataatg aaaaaagaga actcactaat gaacggtaca ttcgaacaag caacatgcag     7320

taccagtgta aaaagtgcaa tgtggttttc cccaggatct ttgacttgat tacgcatcag     7380

aaaaagcagt gttacaagga tgaagatgat gatgcccaag atgaaagcca aacagaagac     7440

tccatggatg ccactgatca agtggtatac aagcattgca cagtgtctgg ccaaacggat     7500

gcagctaaaa acgctgctgc ccctgcagca agttctggct ctgggaccag cacccccctg     7560

attccatcac ccaaaccaga acctgagaag acttctccaa aacctgaata tcccgcagaa     7620

aagccaaagc agagtgaccc ctctccccct tctcaaggca ccaaaccagc cctgccatta     7680

gcatcgactt cctcggaccc accacaggca tccacagccc agccacagcc acagccacag     7740

ccaccaaaac aaccccaact tatcggaaga cctccctcgg cctctcaaac accggtccct     7800

tccagtccac tgcaaatttc catgacgtct ctccagaaca gtctacctcc acagttacta     7860

caataccaat gtgatcagtg tacagttgcc ttcccaactc tggaactctg gcaggaacac     7920

cagcacatgc acttccttgc tgctcaaaac caattccttc actctccgtt cttggaaagg     7980

cccatggaca tgccctacat gatatttgac cccaacaatc cgctgatgac tggacaactg     8040

ctgggcagtt ccctcactca aatgccccct caggccagtt cctcccacac cacagccccc     8100

acaacggttg ctgcttccct aaaaaggaaa ctagacgata aagaagataa taattgcagt     8160

gaaaaagaag gagggaatag cggtgaagac caacaccgag ataaacgctt gagaaccacg     8220

atcaccccgg aacagctgga aatactctat gaaaaatact tgctggattc caatcctacc     8280

agaaaaatgc ttgatcatat tgcccgcgaa gtcgggctga aaaaaagggt cgtgcaagtc     8340

tggttccaga atacacgagc gcgggagagg aaaggccagt tccgggcggt gggtccagca     8400

cagtctcata aacggtgtcc gttttgccga gccctgttta aagcaaagtc ggccttagaa     8460

agccacattc gctctcggca ctggaatgaa ggaaagcagg caggttacag cttgccacca     8520

agccctttaa tatccaccga agatggggga gaaagcccac agaaatacat ctattttgat     8580

tacccatctt tgccattaac taaaattgat ctatcaagtg agaatgaatt ggcttctaca     8640

gtgtcaacac ctgttagtaa aacagcagag ctgtcaccga agaatctttt aagcccttct     8700

tcttttaaag cagagtgttc tgaggatgta gagaatttaa atgcccctcc tgctgaggct     8760

gggtatgatc aaaataaaac cgattttgat gagacttcat cgattaatac ggcaatcagt     8820

gacgccacca ccggagacga gggaaacact gaaatggaaa gcaccacagg aagttccgga     8880

gatgtgaaac cggctttgtc tcccaaagag ccaaaaactc tggatactct gccaaaacct     8940

gcaaccacac ctaccacgga ggtctgcgat gacaaatttc tcttttctct cacaagccca     9000

tccatccatt tcaatgacaa agatggcgac cacgaccaaa gcttttacat cacagatgac     9060

ccggatgaca acgccgaccg cagcgaaacg tccagcatag cggacccgag ctccccaaat     9120

ccattcggat ccagcaatcc ctttaaatcc aaaagtaatg atcggccggg tcacaagcgt     9180

tttcgaacgc aaatgagcaa tcttcaactc aaggttctca aggcttgctt tagtgactac     9240

cgaactccaa ccatgcaaga atgtgaaatg ttagggaatg agattggtct gcccaaacgc     9300

gtagtccagg tgtggttcca aaatgcaagg gcaaaggaaa agaaatttaa aattaacata     9360

gggaagcctt tcatgatcaa tcaaggcgga acggaaggca ccaaaccaga gtgtaccctc     9420

tgcggggtga agtactctgc ccgcttgtcc atcagagatc acattttctc caaacagcac     9480

atttcaaaag tgagggagac cgttggcagt cagctcgatc gggagaaaga ttacttggct     9540

ccgaccacgg ttcggcagct gatggcacag caagaacttg atcgtataaa gaaagcttca     9600

gacgtgctgg gcttgacggt acagcagcca ggcatgatgg acagcagttc tctccacggc     9660

atcagcctgc caacagccta ccccggactc cccggccttc ctccagtcct tctccccgga     9720

atgaacggtc catcctcctt gccgggattt ccacaaaatt caaacacttt aacacctccc     9780

ggtgcaggca tgcttgggtt tcctacttca gctacttcgt ctcctgccct gtctctcagc     9840

agtgccccca ccaaaccttt gctgcagact ccaccacctc caccacctcc tcctcctcct     9900

cctccttcat cctctctgtc aggacagcag accgagcaac agaacaaaga atctgagaaa     9960

aagcaaacta agccaaacaa ggtgaaaaaa atcaaagagg aggaattaga ggccaccaaa    10020

cccgaaaaac accccaaaaa agaggaaaaa atctcatctg ctctttcagt gttgggcaaa    10080

gttgtaggtg aaacacatgt cgatcctatt cagttgcagg cattacagaa tgcaattgct    10140

ggtgacccag cttcctttat aggcggacag ttcttgccat actttatccc tgggtttgct    10200

tcttatttta cacctcagct ccctggaaca gtgcaggggg gatacttccc acctgtctgt    10260

ggcatggaga gcctctttcc ttatggccct acaatgcccc agacactggc aggtctgtcc    10320

ccaggtgcac tgttgcagca gtaccaacag tatcagcaga acctgcagga gtccctgcaa    10380

aagcagcaaa agcaacagca agaacagcag cagaaaccag ttcaggcaaa gacatccaaa    10440

gtagaaagtg accagccgca aaactccaac gatgcttcag aaacaaagga agacaaaagt    10500

actgctacag aaagcacaaa agaagaaccc cagttagaat ccaaaagtgc agacttttca    10560

gacacttacg ttgttccatt cgtcaagtat gagtttatat gcagaaagtg ccagatgatg    10620

tttactgatg aagacgccgc agtaaatcat caaaagtcct tctgttattt cggtcagcct    10680

ttgattgacc cacaagagac agtgcttcgt gtcccagtca gcaaatatca gtgtcttgcc    10740

tgtgatgtgg ctatcagtgg gaatgaagca cttagccaac acctccagtc aagcttgcac    10800

aaagagaaaa caatcaaaca agcaatgaga aatgccaaag agcatgttag attattacct    10860

cactcagtct gctcccctaa tcctaacacc acatctacct cgcagtctgc agcttcttct    10920

aataacacct atcctcatct ttcttgcttc tccatgaagt cctggcctaa tatccttttc    10980

caagcgtctg ccaggagagc tgcttctccc ccttcttctc ctccttccct ttccttgcct    11040

tcaacggtta cctcaagttt gtgcagcacc tcaggggttc aaacctcact acccacagaa    11100

agttgttcag atgagtctga cagtgagctg agccagaagc tagaagactt agataattct    11160

ttggaagtga aggctaagcc tgcttctggc ctagatggta atttcaatag catccgaatg    11220

gatatgttca gtgtgtagga gtgaagacag gatcccgtgc ttaaaaaaat aaaaaataaa    11280

aaaataaaaa aaaaataaga ctttaactgc agttccaaag cttctctaac ccaaaaatta    11340

cagtaccaaa tgattgactc aggattgttt ttcccatatt gatatgctgg caatatagga    11400

tggtatgtaa tggacagaac tgatgcagat ggttgaatgc gcttgtacta tatgctaaaa    11460

tatggaaaag gaaaaaaaaa tctcacaagt tcttttggaa cttgtttcaa gccaaaaact    11520

ctcaagaaag caaattgcac ctcagctgga ttgatttcca aatgctagca tgtactgtat    11580

gggaggatga tccagatgtt tcaaagagaa tttctcttag tttagttagg tgtaattcag    11640

tagctttaaa ttctcaggtc agaacataac atttctcatt tgttaaaagc agcaagaagc    11700

ctggtaaaac tgtgactttt ccccaaacgt caatctttat tagaaagcat tttctaggtg    11760

tgtttagtgt acaaagagac tttataaccc ttactggaca acacacagat ccttgagctc    11820

acgctgcagg atagtacagt tttaccgcag agggaatctg gaacagtgga atcatgtgtc    11880

tgccctgtgt attgcagttt gtattgccac aagctatatt tataccagtg tcaccctttt    11940

cttgtagaat atactaataa tctgtgccaa ctctaccttc tcacttttac ctctgacgtc    12000

attctttttt tctgaaagag gtaataattc tagttttgat agactctgag gattatgtga    12060

acaggacatt tttcatttgt gaatttaatg ctatactgtc aaggtacttg cttgtgtctg    12120

aactctagtg cacttatgat tttgtagacc atgtgaaatt taataagata cctttttttt    12180

cctttctttg tgtgtagtgc agcaacagtt tggtctgcat ttgttagaag tttaactcct    12240

aacaacccaa agacctattt aacaattggt gcataaatga aagtagtact gtatacttga    12300

aactgtttaa gtacaagttg aacaaaaatt atgaaaaggt atatttgctt ctcgggaaag    12360

caaagaagct gctttaaaaa ataaaaaggg gactaaaaat ttgttttgta taaagaggtt    12420

agccctgcgc acgtaggact gaattcagtg atatccctat acactgccat ttagtggata    12480

ggttattgta cttccattca tactctgggc acttgtgttg tattgttctg ttacatactt    12540

tttttaacct gttttgtttt atcatatatg cattaaaagt attatcttta tcaacatttg    12600

ctgctactgt gttaacattt ttgttttgct tgccatgaat ttcaacttcc accacccagt    12660

gaattgattt ataaattgct atgctttgct gtttttctgt tgctgtggaa cttaaagaat    12720

gtgaaagctg tcaaagggta ttttacgaat cacttttgtg tttgatatag taaaacaatg    12780

tgattcattc caaagtaaca gaaggttatt tgtaagaaag ttaaaggctt gtgaacaaag    12840

aaagctaagc tgttgtacat atttgtagtt ggctgtgcat ggtacaaatt tattaatatg    12900

aagaaatgca aaatgtattg cttttgatat ttctcttccg agatgaacaa gtagcatgta    12960

atgcaactgt ttgacagttt aactcaagtc atgcttcaaa ctgttttaat gatcaaatca    13020

agacacattt cattttacat tttattattg tacagttttt gtttcggatg atgatcacag    13080

caatctttat tctatacatt ttatgtgaac ttttttaatg tctttaattt ggattttttt    13140

tttttttagt attttaacat ttattttaat cctgaagaca cttttttgat tgtgtttcgt    13200

aagagacaac atggcctcct aaggtgcaat cctgccgcta tagtgagcta atgtcctgaa    13260

tccaaaggct tcagaaaatt gcttttgcct ttttcatgaa tgttaagcag cagcattgtg    13320

agatcgatct gtcctggcag ttaacacgat gtgcaacagt gtgttagcat ggaacagaac    13380

gcttttcaca aaacaaagga ctgttttaca aatgattatt ccgacagtgt gtcgacataa    13440

acttttacaa ctgcacagca gccaaaaaaa gaaaaaaaaa agaaaaaaaa ctttaactgg    13500

atggacgttg ttagggtgag aaataaaagg acagcctcca aaggttgaga atgagaattg    13560

ttttttcctg gatatcaaag ggattatcac agcgcaatca ttgtctacac aacatgtact    13620

ctcaacgcct gggttacata ggaaatgcac cctgaggttt taataaaagc ccctatggct    13680

ataactttaa ataaactaaa ccaaaaatgt tattgatgtt ttatatatag agagtagtct    13740

cattagtttt tgttactgta atgtttgaag tctcaaatgc accgtattac ggtaaataac    13800

atggttttga aaactttttt ttattttgtc acagacctgt tgtcatagtt gaaatgatgt    13860

ttattgtaga tggtatttga acttattctt ctggaaatag ttcatcaagt atgtttgttg    13920

ctcattgtga tacattaaaa actgtatcta catatttaaa aaaaaaaaaa aaaaa         13975


<210>  21
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  22
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  22
ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga       60

gtgtttgcaa aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga      120

agaggagaga gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa      180

taataataac aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt      240

tgatcctgat tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt      300

tcctcgcgga gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg      360

cccgcgggcc ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc      420

ccgcgcacag cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc      480

agcaaacttc ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga      540

aaaacagccc ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc      600

agcggcgcaa gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc      660

tgggcgccga gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta      720

agcggctgcg agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga      780

aaaccaagac gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg      840

gcggcaatag catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc      900

agcgcatgga cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc      960

aggaccagct gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc     1020

agcccatgca ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga     1080

cctacatgaa cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca     1140

tggctcttgg ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg     1200

ttacctcttc ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca     1260

gcatgtatct ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt     1320

cccagcacta ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct     1380

cacacatgtg agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag     1440

ggaaatggga ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc     1500

tcaaaaagaa aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag     1560

agaacaccaa tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat     1620

gagagagatc ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg     1680

gtggggaggg cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac     1740

tttttaaaag ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc     1800

aataatattt agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac     1860

ttttgtacag tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg     1920

agaatttgcc aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa     1980

atttaggaca gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg     2040

tttaaaaatt gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc     2100

ttgtttaaaa agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc     2160

aaaaatggcc atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa     2220

ctttccattt tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta     2280

tggtttgtaa tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt     2340

ccgtagttgt attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc     2400

atgtatatat ttgaactaat atcatcctta taacaggtac attttcaact taagttttta     2460

ctccattatg cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa     2520


<210>  23
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Leu Gln Gln Leu Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210>  24
<211>  2521
<212>  DNA
<213>  Homo sapiens

<400>  24
aaaaaccggc cgagccccta aaggtgcgga tgcttattat agatcgacgc gacaccagcg       60

cccggtgcca ggttctcccc tgaggctttt cggagcgagc tcctcaaatc gcatccagat      120

tttcgggtcc gagggaagga ggaccctgcg aaagctgcga cgactatctt cccctggggc      180

catggactcg gacgccagcc tggtgtccag ccgcccgtcg tcgccagagc ccgatgacct      240

ttttctgccg gcccggagta agggcagcag cggcagcgcc ttcactgggg gcaccgtgtc      300

ctcgtccacc ccgagtgact gcccgccgga gctgagcgcc gagctgcgcg gcgctatggg      360

ctctgcgggc gcgcatcctg gggacaagct aggaggcagt ggcttcaagt catcctcgtc      420

cagcacctcg tcgtctacgt cgtcggcggc tgcgtcgtcc accaagaagg acaagaagca      480

aatgacagag ccggagctgc agcagctgcg tctcaagatc aacagccgcg agcgcaagcg      540

catgcacgac ctcaacatcg ccatggatgg cctccgcgag gtcatgccgt acgcacacgg      600

cccttcggtg cgcaagcttt ccaagatcgc cacgctgctg ctggcgcgca actacatcct      660

catgctcacc aactcgctgg aggagatgaa gcgactggtg agcgagatct acgggggcca      720

ccacgctggc ttccacccgt cggcctgcgg cggcctggcg cactccgcgc ccctgcccgc      780

cgccaccgcg cacccggcag cagcagcgca cgccgcacat caccccgcgg tgcaccaccc      840

catcctgccg cccgccgccg cagcggctgc tgccgccgct gcagccgcgg ctgtgtccag      900

cgcctctctg cccggatccg ggctgccgtc ggtcggctcc atccgtccac cgcacggcct      960

actcaagtct ccgtctgctg ccgcggccgc cccgctgggg ggcgggggcg gcggcagtgg     1020

ggcgagcggg ggcttccagc actggggcgg catgccctgc ccctgcagca tgtgccaggt     1080

gccgccgccg caccaccacg tgtcggctat gggcgccggc agcctgccgc gcctcacctc     1140

cgacgccaag tgagccgact ggcgccggcg cgttctggcg acaggggagc caggggccgc     1200

ggggaagcga ggactggcct gcgctgggct cgggagctct gtcgcgagga ggggcgcagg     1260

accatggact gggggtgggg catggtgggg attccagcat ctgcgaaccc aagcaatggg     1320

ggcgcccaca gagcagtggg gagtgagggg atgttctctc cgggacctga tcgagcgctg     1380

tctggcttta acctgagctg gtccagtaga catcgtttta tgaaaaggta ccgctgtgtg     1440

cattcctcac tagaactcat ccgacccccg acccccacct ccgggaaaag attctaaaaa     1500

cttctttccc tgagagcgtg gcctgacttg cagactcggc ttgggcagca cttcgggggg     1560

ggagggggtg ttatgggagg gggacacatt ggggccttgc tcctcttcct cctttcttgg     1620

cgggtgggag actccgggta gccgcactgc agaagcaaca gcccgaccgc gccctccagg     1680

gtcgtccctg gcccaaggcc aggggccaca agttagttgg aagccggcgt tcggtatcag     1740

aagcgctgat ggtcatatcc aatctcaata tctgggtcaa tccacaccct cttagaactg     1800

tggccgttcc tccctgtctc tcgttgattt gggagaatat ggttttctaa taaatctgtg     1860

gatgttcctt cttcaacagt atgagcaagt ttatagacat tcagagtaga accacttgtg     1920

gattggaata acccaaaact gccgatttca ggggcgggtg cattgtagtt attattttaa     1980

aatagaaact accccaccga ctcatctttc cttctctaag cacaaagtga tttggttatt     2040

ttggtacctg agaacgtaac agaattaaaa ggcagttgct gtggaaacag tttgggttat     2100

ttgggggttc tgttggcttt ttaaaatttt cttttttgga tgtgtaaatt tatcaatgat     2160

gaggtaagtg cgcaatgcta agctgtttgc tcacgtgact gccagcccca tcggagtcta     2220

agccggcttt cctctatttt ggtttatttt tgccacgttt aacacaaatg gtaaactcct     2280

ccacgtgctt cctgcgttcc gtgcaagccg cctcggcgct gcctgcgttg caaactgggc     2340

tttgtagcgt ctgccgtgta acacccttcc tctgatcgca ccgcccctcg cagagagtgt     2400

atcatctgtt ttatttttgt aaaaacaaag tgctaaataa tatttattac ttgtttggtt     2460

gcaaaaacgg aataaatgac tgagtgttga gattttaaat aaaatttaaa gtaaaaaaaa     2520

a                                                                     2521


<210>  25
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
145                 150                 155                 160 


His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His 
                165                 170                 175     


Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
            180                 185                 190         


Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
        195                 200                 205             


Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
    210                 215                 220                 


Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                245                 250                 255     


Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
            260                 265                 270         


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
        275                 280                 285             


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
    290                 295                 300                 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
305                 310                 315                 320 


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                325                 330                 335     


Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
            340                 345                 350         


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
        355                 360                 365             


Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
    370                 375                 380                 


Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
385                 390                 395                 400 


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                405                 410                 415     


Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
            420                 425                 430         


Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440             


<210>  26
<211>  4108
<212>  DNA
<213>  Homo sapiens

<400>  26
agtaatagca ggagcagcaa cagaaggcgt cggagcgggc gtcggagctg cccgctgtgg       60

gagagagagg agacagaaag agcgagcgag gagagggagc ccgaggcgaa aaagtaactg      120

tcaaatgcgc ggctccttta accggagcgc tcagtccggc tccgagagtc atggcgaccg      180

cagcgtctaa ccactacagc ctgctcacct ccagcgcctc catcgtgcac gccgagccgc      240

ccggcggcat gcagcagggc gcggggggct accgcgaagc gcagagcctg gtgcagggcg      300

actacggcgc tctgcagagc aacggacacc cgctcagcca cgctcaccag tggatcaccg      360

cgctgtccca cggcggcggc ggcgggggcg gtggcggcgg cggggggggc gggggcggcg      420

gcgggggcgg cggcgacggc tccccgtggt ccaccagccc cctgggccag ccggacatca      480

agccctcggt ggtggtgcag cagggcggcc gcggagacga gctgcacggg ccaggcgccc      540

tgcagcagca gcatcagcag cagcaacagc aacagcagca gcaacagcag caacagcagc      600

agcagcagca gcaacagcgg ccgccgcatc tggtgcacca cgccgctaac caccacccgg      660

gacccggggc atggcggagc gcggcggctg cagcgcacct cccaccctcc atgggagcgt      720

ccaacggcgg cttgctctac tcgcagccca gcttcacggt gaacggcatg ctgggcgccg      780

gcgggcagcc ggccggtctg caccaccacg gcctgcggga cgcgcacgac gagccacacc      840

atgccgacca ccacccgcac ccgcactcgc acccacacca gcagccgccg cccccgccgc      900

ccccgcaggg tccgcctggc cacccaggcg cgcaccacga cccgcactcg gacgaggaca      960

cgccgacctc ggacgacctg gagcagttcg ccaagcagtt caagcagcgg cggatcaaac     1020

tgggatttac ccaagcggac gtggggctgg ctctgggcac cctgtatggc aacgtgttct     1080

cgcagaccac catctgcagg tttgaggccc tgcagctgag cttcaagaac atgtgcaagc     1140

tgaagccttt gttgaacaag tggttggagg aggcggactc gtcctcgggc agccccacga     1200

gcatagacaa gatcgcagcg caagggcgca agcggaaaaa gcggacctcc atcgaggtga     1260

gcgtcaaggg ggctctggag agccatttcc tcaaatgccc caagccctcg gcccaggaga     1320

tcacctccct cgcggacagc ttacagctgg agaaggaggt ggtgagagtt tggttttgta     1380

acaggagaca gaaagagaaa aggatgaccc ctcccggagg gactctgccg ggcgccgagg     1440

atgtgtacgg ggggagtagg gacactccac cacaccacgg ggtgcagacg cccgtccagt     1500

gaactcgagc tgggggaggg gcagagcgcg gggctccccc tccccttcgg tccttggccc     1560

tttcccggcc ctcttgttcc ctctctaact tctgattgtt cttttatttt taattattat     1620

ttccccgtcc cttaaaaaga caaaaaaaat aaggcaaaag gaaagcaact aagacactgg     1680

actatccttt aaaggtagca ggtgtaatga tgtgttttga cctttgcagg cgagtaacca     1740

ggcaatggag tggagtgtct cctggagaga gtgaggagag tgtgtgatag ctagaaagag     1800

agagagacag agagatggca agcactgaga taaatacctg gcaaaactaa ataaattacc     1860

aaaaaggaaa aaaaatccac caaaccatga taaacacaaa atgcagcttc ctgatgctta     1920

gagttggcac atgctgctgt gtttatttat tgtggattcc catcaggaaa gaggaaaaaa     1980

tacacatgtt ctttcatata ggcaaaattt aaccacataa atttgcactg caagaaaatt     2040

gaagtttacg tgaacaaatt catgagcata ttttctcttt ctccccaccg ttaatttggg     2100

agttgccgtt ttgggggatt ttgttttgct ttgctttatt catcggagag agttgaagcc     2160

agctcttggc cactctccat ttctaatgtt cttgtgttgc cccttcttcg tactgtttgt     2220

gaactttggt taccttcaca ttccccttac gagggtgtaa catctatttg ttcctcttac     2280

caaagcaaaa ggattggctt catacaaaat agacaattct ctgatttcag gaaatgtgca     2340

tggtctaccc gctttatcga aggcaagaat ccggtttgga atataaaaat aagcattggt     2400

tgttcttacc agccacaaag taaacttcat tttcaggcag tgtttctggg ggaggttatg     2460

gagggaagaa aaaagaaaaa tcgatagtga gtgactgatt gcttcatttt atcaggcggg     2520

cccattgtga aagagctcag gggaaatgtg gaggttaaat atatttccag agttgtccag     2580

cagaaagaaa gtggcacttt gaagagaact agggaagtac atatcttcag atatccctat     2640

atagttctct accttcagtt ttagtaacaa ttatgaagaa ttatttgtgc tgacagcagc     2700

agttaaactt tgtttctcta atagcttttt ttttacataa aaaaagaccc aggaacttaa     2760

tagtgtatgc ataagactgt gttttttagc acacagatac ccacagcata cactgacgat     2820

ctccacgcag tagacaggtt ttgtcttcac tagctcattt gtttatcaag tcatatttag     2880

ggtcccacac cctcttttcc tgtaatttat tgcagaatac accactttga cttggacagc     2940

tttctgcccc ctctttcact aaggaaggca aatgaagtga aaaaaaaaaa tgccattttc     3000

aatccttcct ttctcccctt tgttaatagt tttaagtgaa tttttgacct tatcttaatg     3060

gaaaacggtt aactccaaac acaaaagact ctactggaaa gtgtaggtga aaaaacttgt     3120

aactgtattg aaaataaata ccattaaact gtgatcagtt aaaatttaaa agaaaaatca     3180

gcacaaaagg gcgctaaaag ggaaaacact ttttattaat cttaaaagtt tgggggtttt     3240

tttccagtta ggtattagat aaatttttat tttaaaaaat gaaagtctca ctaccataaa     3300

attatggttc agcatcagat tagcattgca ctcagtagtc tttaaggttt taggaaatat     3360

gctttatatt gtcttttcaa acacctgtga ttgtttcatt ttccatgttt ttgcaagata     3420

aatggtgact tataatgggc atatttattt gcctgtattt catttccccc aatgaatgtc     3480

acaaggagat gggcacggag ctgcttcggg tgcatcacgc tgctcgttcc tgaggtatgg     3540

gaactggcct ttagtgaagc tatccagagc agggcaaata gccactggta aagggaggaa     3600

atgaatttcc agatacttat taccaagtag gtaaggtcag aagctggagt tcagagaatg     3660

tgtctacagc ttctctgact cttataggtt tactaagatg aaagttacca ctgaacctta     3720

ccactatgta tatatgttta atatctgtct tttgaaatgc agaaatagtt taaatgtttc     3780

tttgtctatt tttctttttt tttaatgcta cccagggaaa tattttcata tcatttttaa     3840

gtggcctgcc tcaatgtata tttatttctt ttgaaacaaa aaggttctgg aaactgtttt     3900

tctgtagctt taaatgaata ggtgagcaaa atctatatgg gatgtaattt ttttgttcag     3960

tctcttaaaa aatactttgt tttggtacat ttggttgtgc ttgtggggaa aataaaaacg     4020

cagagatcct tatatattta tgttaaagta atattttatt atctacataa aacagaaatg     4080

cacaataaaa aaaaaaaaaa aaaaaaaa                                        4108


<210>  27
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  28
<211>  3053
<212>  DNA
<213>  Homo sapiens

<400>  28
ggcgcggcgg gagcgcgctt ggcgcgtgcg tacgcgacgg cggttggcgg cgcgcgggca       60

gcgtgaagcg aggcgaggca aggcttttcg gacccacgga gcgacagagc gagcggcccc      120

tacggccgtc ggcggcccgg cggcccgaga tgttatctgg gaagaaggcg gcagccgcgg      180

cggcggcggc tgcagcggca gcaaccggga cggaggctgg ccctgggaca gcaggcggct      240

ccgagaacgg gtctgaggtg gccgcgcagc ccgcgggcct gtcgggccca gccgaggtcg      300

ggccgggggc ggtgggggag cgcacacccc gcaagaaaga gcctccgcgg gcctcgcccc      360

ccgggggcct ggcggaaccg ccggggtccg cagggcctca ggccggccct actgtcgtgc      420

ctgggtctgc gacccccatg gaaactggaa tagcagagac tccggagggg cgtcggacca      480

gccggcgcaa gcgggcgaag gtagagtaca gagagatgga tgaaagcttg gccaacctct      540

cagaagatga gtattattca gaagaagaga gaaatgccaa agcagagaag gaaaagaagc      600

ttcccccacc accccctcaa gccccacctg aggaagaaaa tgaaagtgag cctgaagaac      660

catcgggtgt ggagggcgca gctttccaga gccgacttcc tcatgaccgg atgacttctc      720

aagaagcagc ctgttttcca gatattatca gtggaccaca acagacccag aaggtttttc      780

ttttcattag aaaccgcaca ctgcagttgt ggttggataa tccaaagatt cagctgacat      840

ttgaggctac tctccaacaa ttagaagcac cttataacag tgatactgtg cttgtccacc      900

gagttcacag ttatttagag cgtcatggtc ttatcaactt cggcatctat aagaggataa      960

aacccctacc aactaaaaag acaggaaagg taattattat aggctctggg gtctcaggct     1020

tggcagcagc tcgacagtta caaagttttg gaatggatgt cacacttttg gaagccaggg     1080

atcgtgtggg tggacgagtt gccacatttc gcaaaggaaa ctatgtagct gatcttggag     1140

ccatggtggt aacaggtctt ggagggaatc ctatggctgt ggtcagcaaa caagtaaata     1200

tggaactggc caagatcaag caaaaatgcc cactttatga agccaacgga caagctgttc     1260

ctaaagagaa agatgaaatg gtagagcaag agtttaaccg gttgctagaa gctacatctt     1320

accttagtca tcaactagac ttcaatgtcc tcaataataa gcctgtgtcc cttggccagg     1380

cattggaagt tgtcattcag ttacaagaga agcatgtcaa agatgagcag attgaacatt     1440

ggaagaagat agtgaaaact caggaagaat tgaaagaact tcttaataag atggtaaatt     1500

tgaaagagaa aattaaagaa ctccatcagc aatacaaaga agcatctgaa gtaaagccac     1560

ccagagatat tactgccgag ttcttagtga aaagcaaaca cagggatctg accgccctat     1620

gcaaggaata tgatgaatta gctgaaacac aaggaaagct agaagaaaaa cttcaggagt     1680

tggaagcgaa tcccccaagt gatgtatatc tctcatcaag agacagacaa atacttgatt     1740

ggcattttgc aaatcttgaa tttgctaatg ccacacctct ctcaactctc tcccttaagc     1800

actgggatca ggatgatgac tttgagttca ctggcagcca cctgacagta aggaatggct     1860

actcgtgtgt gcctgtggct ttagcagaag gcctagacat taaactgaat acagcagtgc     1920

gacaggttcg ctacacggct tcaggatgtg aagtgatagc tgtgaatacc cgctccacga     1980

gtcaaacctt tatttataaa tgcgacgcag ttctctgtac ccttcccctg ggtgtgctga     2040

agcagcagcc accagccgtt cagtttgtgc cacctctccc tgagtggaaa acatctgcag     2100

tccaaaggat gggatttggc aaccttaaca aggtggtgtt gtgttttgat cgggtgttct     2160

gggatccaag tgtcaatttg ttcgggcatg ttggcagtac gactgccagc aggggtgagc     2220

tcttcctctt ctggaacctc tataaagctc caatactgtt ggcactagtg gcaggagaag     2280

ctgctggtat catggaaaac ataagtgacg atgtgattgt tggccgatgc ctggccattc     2340

tcaaagggat ttttggtagc agtgcagtac ctcagcccaa agaaactgtg gtgtctcgtt     2400

ggcgtgctga tccctgggct cggggctctt attcctatgt tgctgcagga tcatctggaa     2460

atgactatga tttaatggct cagccaatca ctcctggccc ctcgattcca ggtgccccac     2520

agccgattcc acgactcttc tttgcgggag aacatacgat ccgtaactac ccagccacag     2580

tgcatggtgc tctgctgagt gggctgcgag aagcgggaag aattgcagac cagtttttgg     2640

gggccatgta tacgctgcct cgccaggcca caccaggtgt tcctgcacag cagtccccaa     2700

gcatgtgaga cagatgcatt ctaagggaag aggcccatgt gcctgtttct gccatgtaag     2760

gaaggctctt ctagcaatac tagatcccac tgagaaaatc caccctggca tctgggctcc     2820

tgatcagctg atggagctcc tgatttgaca aaggagcttg cctcctttga atgacctaga     2880

gcacagggag gaacttgtcc attagtttgg aattgtgttc ttcgtaaaga ctgaggcaag     2940

caagtgctgt gaaataacat catcttagtc ccttggtgtg tggggttttt gttttttttt     3000

tatattttga gaataaaact tcatataaaa ttggcaaaaa aaaaaaaaaa aaa            3053


<210>  29
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210>  30
<211>  3125
<212>  DNA
<213>  Homo sapiens

<400>  30
ggcgcggcgg gagcgcgctt ggcgcgtgcg tacgcgacgg cggttggcgg cgcgcgggca       60

gcgtgaagcg aggcgaggca aggcttttcg gacccacgga gcgacagagc gagcggcccc      120

tacggccgtc ggcggcccgg cggcccgaga tgttatctgg gaagaaggcg gcagccgcgg      180

cggcggcggc tgcagcggca gcaaccggga cggaggctgg ccctgggaca gcaggcggct      240

ccgagaacgg gtctgaggtg gccgcgcagc ccgcgggcct gtcgggccca gccgaggtcg      300

ggccgggggc ggtgggggag cgcacacccc gcaagaaaga gcctccgcgg gcctcgcccc      360

ccgggggcct ggcggaaccg ccggggtccg cagggcctca ggccggccct actgtcgtgc      420

ctgggtctgc gacccccatg gaaactggaa tagcagagac tccggagggg cgtcggacca      480

gccggcgcaa gcgggcgaag gtagagtaca gagagatgga tgaaagcttg gccaacctct      540

cagaagatga gtattattca gaagaagaga gaaatgccaa agcagagaag gaaaagaagc      600

ttcccccacc accccctcaa gccccacctg aggaagaaaa tgaaagtgag cctgaagaac      660

catcggggca agcaggagga cttcaagacg acagttctgg agggtatgga gacggccaag      720

catcaggtgt ggagggcgca gctttccaga gccgacttcc tcatgaccgg atgacttctc      780

aagaagcagc ctgttttcca gatattatca gtggaccaca acagacccag aaggtttttc      840

ttttcattag aaaccgcaca ctgcagttgt ggttggataa tccaaagatt cagctgacat      900

ttgaggctac tctccaacaa ttagaagcac cttataacag tgatactgtg cttgtccacc      960

gagttcacag ttatttagag cgtcatggtc ttatcaactt cggcatctat aagaggataa     1020

aacccctacc aactaaaaag acaggaaagg taattattat aggctctggg gtctcaggct     1080

tggcagcagc tcgacagtta caaagttttg gaatggatgt cacacttttg gaagccaggg     1140

atcgtgtggg tggacgagtt gccacatttc gcaaaggaaa ctatgtagct gatcttggag     1200

ccatggtggt aacaggtctt ggagggaatc ctatggctgt ggtcagcaaa caagtaaata     1260

tggaactggc caagatcaag caaaaatgcc cactttatga agccaacgga caagctgaca     1320

ctgtcaaggt tcctaaagag aaagatgaaa tggtagagca agagtttaac cggttgctag     1380

aagctacatc ttaccttagt catcaactag acttcaatgt cctcaataat aagcctgtgt     1440

cccttggcca ggcattggaa gttgtcattc agttacaaga gaagcatgtc aaagatgagc     1500

agattgaaca ttggaagaag atagtgaaaa ctcaggaaga attgaaagaa cttcttaata     1560

agatggtaaa tttgaaagag aaaattaaag aactccatca gcaatacaaa gaagcatctg     1620

aagtaaagcc acccagagat attactgccg agttcttagt gaaaagcaaa cacagggatc     1680

tgaccgccct atgcaaggaa tatgatgaat tagctgaaac acaaggaaag ctagaagaaa     1740

aacttcagga gttggaagcg aatcccccaa gtgatgtata tctctcatca agagacagac     1800

aaatacttga ttggcatttt gcaaatcttg aatttgctaa tgccacacct ctctcaactc     1860

tctcccttaa gcactgggat caggatgatg actttgagtt cactggcagc cacctgacag     1920

taaggaatgg ctactcgtgt gtgcctgtgg ctttagcaga aggcctagac attaaactga     1980

atacagcagt gcgacaggtt cgctacacgg cttcaggatg tgaagtgata gctgtgaata     2040

cccgctccac gagtcaaacc tttatttata aatgcgacgc agttctctgt acccttcccc     2100

tgggtgtgct gaagcagcag ccaccagccg ttcagtttgt gccacctctc cctgagtgga     2160

aaacatctgc agtccaaagg atgggatttg gcaaccttaa caaggtggtg ttgtgttttg     2220

atcgggtgtt ctgggatcca agtgtcaatt tgttcgggca tgttggcagt acgactgcca     2280

gcaggggtga gctcttcctc ttctggaacc tctataaagc tccaatactg ttggcactag     2340

tggcaggaga agctgctggt atcatggaaa acataagtga cgatgtgatt gttggccgat     2400

gcctggccat tctcaaaggg atttttggta gcagtgcagt acctcagccc aaagaaactg     2460

tggtgtctcg ttggcgtgct gatccctggg ctcggggctc ttattcctat gttgctgcag     2520

gatcatctgg aaatgactat gatttaatgg ctcagccaat cactcctggc ccctcgattc     2580

caggtgcccc acagccgatt ccacgactct tctttgcggg agaacatacg atccgtaact     2640

acccagccac agtgcatggt gctctgctga gtgggctgcg agaagcggga agaattgcag     2700

accagttttt gggggccatg tatacgctgc ctcgccaggc cacaccaggt gttcctgcac     2760

agcagtcccc aagcatgtga gacagatgca ttctaaggga agaggcccat gtgcctgttt     2820

ctgccatgta aggaaggctc ttctagcaat actagatccc actgagaaaa tccaccctgg     2880

catctgggct cctgatcagc tgatggagct cctgatttga caaaggagct tgcctccttt     2940

gaatgaccta gagcacaggg aggaacttgt ccattagttt ggaattgtgt tcttcgtaaa     3000

gactgaggca agcaagtgct gtgaaataac atcatcttag tcccttggtg tgtggggttt     3060

ttgttttttt tttatatttt gagaataaaa cttcatataa aattggcaaa aaaaaaaaaa     3120

aaaaa                                                                 3125


<210>  31
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Ser Val Met Glu Lys Pro Ser Ala Gly Ser Gly Ile Leu Ser 
1               5                   10                  15      


Arg Ser Arg Ala Lys Thr Val Pro Asn Gly Gly Gln Pro His Ser Glu 
            20                  25                  30          


Asp Asp Ser Ser Glu Glu Glu His Ser His Asp Ser Met Ile Arg Val 
        35                  40                  45              


Gly Thr Asn Tyr Gln Ala Val Ile Pro Glu Cys Lys Pro Glu Ser Pro 
    50                  55                  60                  


Ala Arg Tyr Ser Asn Lys Glu Leu Lys Gly Met Leu Val Trp Ser Pro 
65                  70                  75                  80  


Asn His Cys Val Ser Asp Ala Lys Leu Asp Lys Tyr Ile Ala Met Ala 
                85                  90                  95      


Lys Glu Lys His Gly Tyr Asn Ile Glu Gln Ala Leu Gly Met Leu Leu 
            100                 105                 110         


Trp His Lys His Asp Val Glu Lys Ser Leu Ala Asp Leu Ala Asn Phe 
        115                 120                 125             


Thr Pro Phe Pro Asp Glu Trp Thr Val Glu Asp Lys Val Leu Phe Glu 
    130                 135                 140                 


Gln Ala Phe Gly Phe His Gly Lys Cys Phe Gln Arg Ile Gln Gln Met 
145                 150                 155                 160 


Leu Pro Asp Lys Leu Ile Pro Ser Leu Val Lys Tyr Tyr Tyr Ser Trp 
                165                 170                 175     


Lys Lys Thr Arg Ser Arg Thr Ser Val Met Asp Arg Gln Ala Arg Arg 
            180                 185                 190         


Leu Gly Gly Arg Lys Asp Lys Glu Asp Ser Asp Glu Leu Glu Glu Gly 
        195                 200                 205             


Arg Gly Gly Val Ser Glu Gly Glu Pro Asp Pro Ala Asp Pro Lys Arg 
    210                 215                 220                 


Glu Pro Leu Pro Ser Arg Pro Leu Asn Ala Arg Pro Gly Pro Gly Lys 
225                 230                 235                 240 


Lys Glu Val Gln Val Ser Gln Tyr Arg His His Pro Leu Arg Thr Arg 
                245                 250                 255     


Arg Arg Pro Pro Lys Gly Met Tyr Leu Ser Pro Glu Gly Leu Thr Ala 
            260                 265                 270         


Val Ser Gly Ser Pro Asp Leu Ala Asn Leu Thr Leu Arg Gly Leu Asp 
        275                 280                 285             


Ser Gln Leu Ile Ser Leu Lys Arg Gln Val Gln Ser Met Lys Gln Thr 
    290                 295                 300                 


Asn Ser Ser Leu Arg Gln Ala Leu Glu Gly Gly Ile Asp Pro Leu Arg 
305                 310                 315                 320 


Pro Pro Glu Ala Asn Thr Lys Phe Asn Ser Arg Trp Thr Thr Asp Glu 
                325                 330                 335     


Gln Leu Leu Ala Val Gln Ala Ile Arg Arg Tyr Gly Lys Asp Phe Gly 
            340                 345                 350         


Ala Ile Ala Glu Val Ile Gly Asn Lys Thr Leu Thr Gln Val Lys Thr 
        355                 360                 365             


Phe Phe Val Ser Tyr Arg Arg Arg Phe Asn Leu Glu Glu Val Leu Gln 
    370                 375                 380                 


Glu Trp Glu Ala Glu Gln Asp Gly Ala Pro Gly Ala Pro Val Pro Met 
385                 390                 395                 400 


Glu Glu Ala Arg Arg Gly Ala Pro Leu Pro Ala Pro Ala Leu Glu Glu 
                405                 410                 415     


Asp Asp Glu Val Gln Ile Thr Ser Val Ser Thr Ser Val Pro Arg Ser 
            420                 425                 430         


Val Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Thr Ser Leu Ser Gln 
        435                 440                 445             


Pro Pro Pro Leu Leu Arg Pro Pro Leu Pro Thr Ala Pro Thr Leu Leu 
    450                 455                 460                 


Arg Gln Pro Pro Pro Leu Gln Gln Gly Arg Phe Leu Gln Pro Arg Leu 
465                 470                 475                 480 


Ala Pro Asn Gln Pro Pro Pro Pro Leu Ile Arg Pro Ala Leu Ala Ala 
                485                 490                 495     


Pro Arg His Ser Ala Arg Pro Gly Pro Gln Pro Pro Pro Thr Leu Ile 
            500                 505                 510         


Gly Thr Pro Leu Glu Pro Pro Ala Pro Ser Leu 
        515                 520             


<210>  32
<211>  2621
<212>  DNA
<213>  Homo sapiens

<400>  32
gcgcccagcc gctgaacggc gtgggcaggt gggcggtggg gttccagggc gccccgagga       60

cagggggccc cgacttcagg ggaaccccaa ccctgagggg cgtacatagt aatcacgccc      120

cagccgcacc ggaccttgcg ctcatccctt gcgtccccca cttctgcaca aacttttctg      180

acgccctggc tcgtgggggt cgtggagagc gctggggcta ccaggtgggc tcccaccccg      240

ccggacccta gccacgctga cctcctgcct ctcctaacct cagtggcgac ctctccaggc      300

cgggccgggc tcggcactcg gagcgagtgc ggcaaccact gtcgctctcc gaaggctcct      360

gcgccccccg gggcagctgg gcggggtaat gccctcagtg atggagaagc cgagcgcggg      420

ctctgggatc ctgtcccgta gccgggccaa gacggtgccc aacggcggac agccccactc      480

ggaggatgac agcagcgagg aggagcactc gcacgacagc atgatccgcg ttggaaccaa      540

ttaccaggcc gtaattccgg agtgcaagcc tgagagcccc gcacgctaca gcaacaagga      600

gctgaagggg atgctggtgt ggtcacccaa ccactgtgtg tcagatgcca agcttgacaa      660

gtacattgcg atggccaagg agaagcatgg ctacaacatt gagcaggcgc tgggcatgct      720

tctgtggcat aagcacgatg tggagaagtc gctggccgac ctggccaact tcaccccatt      780

ccctgacgag tggacagtag aggacaaggt gctgtttgaa caggcctttg gcttccatgg      840

caaatgcttc cagcggatcc agcagatgct gcctgacaag ttgattccca gcctggtgaa      900

atactactac tcttggaaga agacccgcag ccgaactagt gtgatggaca gacaggcccg      960

gcggctgggg ggccgcaagg acaaagaaga cagtgatgag ctcgaagagg gtcgaggagg     1020

cgtgagtgag ggagagcccg atcctgcaga tcccaagaga gagcctctac cctctcggcc     1080

cctgaatgca cgcccaggcc ctgggaaaaa ggaggtccag gtgtctcagt accgccacca     1140

tcccttgcga acccggcgtc gcccacccaa gggcatgtac ctgagccctg aaggcctcac     1200

ggcagtgtca ggaagcccgg accttgccaa cctcacgctc cgaggtcttg actctcagct     1260

catctccctc aagcgccagg tacagagcat gaagcagacg aacagcagcc tgcgccaagc     1320

cctggagggc ggtattgatc cactacgccc cccggaggcc aacaccaagt tcaactcccg     1380

ctggaccaca gatgagcagc ttttggctgt tcaagccatc cgtaggtatg gcaaagactt     1440

tggggctatt gcagaggtga ttgggaacaa gactctgacc caggtgaaga ctttctttgt     1500

gagctaccgg cgccgcttca atctggagga ggtgctgcag gaatgggagg ctgagcagga     1560

tggggcccct ggagccccag tccccatgga ggaggctagg agaggggctc cattgccagc     1620

cccagcccta gaggaagatg atgaggtcca gattacatcg gtctccacgt ccgtgccccg     1680

atcagtgccc cctgcgccac caccccctcc acctcccacc tcgctgtccc agccaccccc     1740

gctgctgagg ccacctttgc ccacggctcc cactctgctc cgacagccac ccccactgca     1800

gcagggccgc ttcctccagc cccggctggc ccccaaccag cccccaccgc ctctcatccg     1860

ccccgctctg gctgcccccc gccacagcgc ccgccctggc cctcagcccc cacccaccct     1920

gattggaacc cctctggagc ccccagcacc ctcactctga gccctgacgt cctccaccaa     1980

ccacgggctc caggacccct ttgctggcca tccccaggca tctctggtgt cactgaggac     2040

agaagggact agggctctgg cggggtcttt gtaagaccag agtttcggac agcccagccc     2100

cgccctttgg gttctgcatg tgttcctggc agctgggcct gtctcctggg gccatggccg     2160

ggctcagggg cctttgagct ggcctgaggg cactttcgct tcctggccgg tactggaatg     2220

gctgtgtcct agtctgctgg ggcttggcct ctgggtcctg ccctttgtgt gtccggggta     2280

gtgaccttag cgtggagtgg ggagagggca gttgggtgtg ctggctgttc tcattcctct     2340

ttcccttctt ttagcaataa gtctggggtg aggtggggag ggaggctgca gggggggagg     2400

tgggcagagg ggccttacag cagcagaggc tggaagagaa gctctgtctt caggggccag     2460

ctgggaaatg ctaaggagct gagggtgccc accaagccca ccttccagaa acttggagaa     2520

atgggggttg ggaacttatg cagacatgga tttatttttc aacatttttt aaaaattaaa     2580

aaaaataaaa tctaagctta ctgaaaaaaa aaaaaaaaaa a                         2621


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
gttgttcctg aaggttactg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gctggtgcaa caacattgct                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
gcacggcgtg gactacttga                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sythetic oligonucleotide

<400>  36
gctgcaccgt gttcatgccc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
gagctggacg gcgacgtaaa                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sythentic oligonucleotide

<400>  38
accaacttgc ccaggttcaa                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
gttcaagagc agcctaggca                                                   20


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
cagcagatct ttttgcacaa gc                                                22


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
tgcccaaagt tacaagagcc a                                                 21


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
atgaacacgg tgcagctgta                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
agggccagct ggtactgata                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
gttcctgctt ccttcccctc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
tgcacagtcc ccgcattaat                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
cagggttcga ttccgtagag                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sythetic oligonucleotide

<400>  47
cctccagtgg atcctcgtta                                                   20


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
caccccagca aaccatatta tgc                                               23


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
cacacagcca tgcagggatt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
tggatacgtg gcgtaaaatg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
cgagcagact ggcatctgta                                                   20


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
gtgctcacgc tcggagaaa                                                    19


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
gtgggaaaca gctcgaatgg t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
caggtctcgt gccaatcaaa a                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  55
gctgttgctg gtgtgtattc t                                                 21


