                         SEQUENCE LISTING

<110>  National institute for biotechnology of the Negev
 
<120>  VARIANTS OF AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN

<130>  NIBN-P-014-PCT

<150>  US 62/265,719
<151>  2015-12-10

<150>  US 62/313,824
<151>  2016-03-28

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine, serine, cysteine or valine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine, cysteine, leucine, histidine, serine, phenylalanine
       or alanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine, leucine, tyrosine or tryptophan

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine, isoleucine, leucine or methionine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine, cysteine, isoleucine, leucine or methionine

<400>  1

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  2
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine, serine, cysteine or valine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine, cysteine or alanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine, leucine, tyrosine or tryptophan

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine, isoleucine, leucine or methionine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine, cysteine, isoleucine, leucine or methionine

<400>  2

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  3
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine or valine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine

<400>  3

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  4
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine, leucine, histidine, serine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine

<400>  4

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  5
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine or leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine

<400>  5

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  6
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is valine

<400>  6

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  7
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Gly Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  8
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8

Glu Val Cys Ser Glu Gln Ala Glu Val Gly Pro Cys Arg Ala Gly Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  9
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Gly Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Leu Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  10
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10

Glu Val Cys Ser Glu Gln Ala Glu Cys Gly Pro Cys Arg Ala Gly Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Cys 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  11
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Cys Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Cys 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  12
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Leu Phe 
1               5                   10                  15      


Phe Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  13
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Leu Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  14
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala His Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  15
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Ser Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  16
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Phe Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  17
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Gly Ile 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  18
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  19
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  20
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Gly Ile 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  21
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Gly Phe 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  22
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Val 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  23
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
1               5                   10                  15      


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


<210>  24
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24
gatggtattt cgatgttact gaaggtaaat gtgctccatt cttctatggt ggttgtggtg       60


<210>  25
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25
ccacaaacag ccatacaata ttcttcagta tcgaaattat ttctattacc accacaacca       60

ccatagaaga at                                                           72


<210>  26
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26
gaagtttgtt ctgaacaagc tgaaactggt ccatgtagag ctatgatttc tagatggtat       60

ttcgatgtta ctg                                                          73


<210>  27
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27
ggaaagccaa tggtttatct ggcaaggatc caatagcaga accacaaaca gccatacaat       60

attc                                                                    64


<210>  28
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28
ggtggttctg gtggtggtgg ttctggtggt ggtggtctgc tagcgaagtt tgttctgaac       60

aagctg                                                                  66


<210>  29
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29
gagctattac aagtcctctt cagaaataag cttttgttca gatggatctt ggaaagccaa       60

tggtttatc                                                               69


<210>  30
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30
gaagtttgtt ctgaacaagc tgaaactggt ccatgtagag ctggtttttc tagatggtat       60

ttcgatgtta ctg                                                          73


<210>  31
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31
gaagtttgtt ctgaacaagc tgaaactggt ccatgtagag ctggtatttc tagatggtat       60

ttcgatgtta ctg                                                          73


<210>  32
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32
gaagtttgtt ctgaacaagc tgaaactggt ccatgtagag ctatgttttc tagatggtat       60

ttcgatgtta ctg                                                          73


<210>  33
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33
ccacaaacag ccatacaata ttcttcagta tcgaaattat ttctattacc accacaacca       60

ccatagacga atg                                                          73


<210>  34
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34
agcgtatacg tagactataa ggatgacgac gacaaagaat tcgaagtttg ttctgaacaa       60

gctg                                                                    64


<210>  35
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35
atagtttagc ggccgcatga tggtggtgat ggtgcctagg aatagcagaa ccacaaacag       60

c                                                                       61


<210>  36
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36
cggagcgaat tcgaagtttg ttctgaacaa gctg                                   34


<210>  37
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37
cgctacccta ggaatagcag aaccacaaac agc                                    33


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  38
gactggttcc aattgacaag c                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  39
gcaaatggca ttctgacatc c                                                 21


<210>  40
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is cysteine, valine or threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is glycine or cysteine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is serine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is is cysteine

<400>  40

Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Xaa Xaa 
1               5                   10                  15      


Xaa Arg Trp Tyr Phe Asp Val Thr Glu Gly Xaa Cys Ala Pro Phe Xaa 
            20                  25                  30          


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
        35                  40                  45              


Cys Met Ala Val Cys Gly Ser Ala Ile 
    50                  55          


