                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
       Rijksuniversiteit Groningen
 
<120>  BETA-GLUCOSIDASE AND USES THEREOF

<130>  31729-WO-PCT

<150>  EP15198954.8
<151>  2015-12-10

<150>  EP15198958.9
<151>  2015-12-10

<150>  EP15198789.8
<151>  2015-12-10

<150>  EP15198795.5
<151>  2015-12-10

<150>  EP15198803.7
<151>  2015-12-10

<150>  EP15199044.7
<151>  2015-12-10

<150>  EP15199086.8
<151>  2015-12-10

<150>  EP15199108.0
<151>  2015-12-10

<150>  EP15199109.8
<151>  2015-12-10

<150>  EP15199145.2
<151>  2015-12-10

<150>  EP15199152.8
<151>  2015-12-10

<150>  EP15198844.1
<151>  2015-12-10

<150>  EP15199030.6
<151>  2015-12-10

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2574
<212>  DNA
<213>  Talaromyces emersonii


<220>
<221>  CDS
<222>  (1)..(2574)

<400>  1
atg cgc aac ggt ctg ctc aag gtt gct gct ctt gct gct gcc tcc gcc         48
Met Arg Asn Gly Leu Leu Lys Val Ala Ala Leu Ala Ala Ala Ser Ala           
1               5                   10                  15                

gtc aac ggc gag aac ctg gcc tac tct cct ccc ttc tac ccc tcc ccc         96
Val Asn Gly Glu Asn Leu Ala Tyr Ser Pro Pro Phe Tyr Pro Ser Pro           
            20                  25                  30                    

tgg gcc aac ggc cag ggt gac tgg gct gag gcc tac cag aag gcc gtc        144
Trp Ala Asn Gly Gln Gly Asp Trp Ala Glu Ala Tyr Gln Lys Ala Val           
        35                  40                  45                        

cag ttc gtc agc cag ctc acc ctg gct gag aag gtc aac ctg acc act        192
Gln Phe Val Ser Gln Leu Thr Leu Ala Glu Lys Val Asn Leu Thr Thr           
    50                  55                  60                            

ggt act ggc tgg gag cag gac cgc tgc gtt ggc cag gtc ggc tcc atc        240
Gly Thr Gly Trp Glu Gln Asp Arg Cys Val Gly Gln Val Gly Ser Ile           
65                  70                  75                  80            

ccc cgt ctt ggt ttc ccc ggt ctt tgc atg cag gac tct cct ctt ggt        288
Pro Arg Leu Gly Phe Pro Gly Leu Cys Met Gln Asp Ser Pro Leu Gly           
                85                  90                  95                

gtc cgt gac acc gac tac aac tct gct ttc cct gct ggt gtc aac gtc        336
Val Arg Asp Thr Asp Tyr Asn Ser Ala Phe Pro Ala Gly Val Asn Val           
            100                 105                 110                   

gct gcc acc tgg gac cgc aac ctg gcc tac cgc cgt ggt gtt gcc atg        384
Ala Ala Thr Trp Asp Arg Asn Leu Ala Tyr Arg Arg Gly Val Ala Met           
        115                 120                 125                       

ggt gag gag cac cgt ggc aag ggt gtt gat gtc cag ctc ggt cct gtt        432
Gly Glu Glu His Arg Gly Lys Gly Val Asp Val Gln Leu Gly Pro Val           
    130                 135                 140                           

gct ggt cct ctg ggc cgc tct ccc gat gct ggc cgc aac tgg gag ggt        480
Ala Gly Pro Leu Gly Arg Ser Pro Asp Ala Gly Arg Asn Trp Glu Gly           
145                 150                 155                 160           

ttc gct cct gac ccc gtc ctc act ggt aac atg atg gcc tcc acc atc        528
Phe Ala Pro Asp Pro Val Leu Thr Gly Asn Met Met Ala Ser Thr Ile           
                165                 170                 175               

cag ggt atc cag gat gct ggt gtc att gcc tgc gcc aag cac ttc atc        576
Gln Gly Ile Gln Asp Ala Gly Val Ile Ala Cys Ala Lys His Phe Ile           
            180                 185                 190                   

ctg tac gag cag gag cac ttc cgc cag ggt gct cag gat ggc tac gat        624
Leu Tyr Glu Gln Glu His Phe Arg Gln Gly Ala Gln Asp Gly Tyr Asp           
        195                 200                 205                       

ata tct gac tcc atc tcc gcc aac gcc gat gac aag acc atg cac gag        672
Ile Ser Asp Ser Ile Ser Ala Asn Ala Asp Asp Lys Thr Met His Glu           
    210                 215                 220                           

ctc tac ctc tgg ccc ttc gcc gat gcc gtc cgt gct ggt gtt ggc tcc        720
Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser           
225                 230                 235                 240           

gtc atg tgc tcc tac aac cag gtc aac aac tcc tac gcc tgc tcc aac        768
Val Met Cys Ser Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Ser Asn           
                245                 250                 255               

agc tac acc atg aac aag ctc ttg aaa tca gag ctt ggt ttc cag ggt        816
Ser Tyr Thr Met Asn Lys Leu Leu Lys Ser Glu Leu Gly Phe Gln Gly           
            260                 265                 270                   

ttc gtc atg act gac tgg ggt ggt cac cac tct ggt gtt ggt tcc gct        864
Phe Val Met Thr Asp Trp Gly Gly His His Ser Gly Val Gly Ser Ala           
        275                 280                 285                       

ctt gct ggt ctt gac atg agc atg ccc ggt gac att gct ttc gac tcc        912
Leu Ala Gly Leu Asp Met Ser Met Pro Gly Asp Ile Ala Phe Asp Ser           
    290                 295                 300                           

ggt acc tcc ttc tgg ggt acc aac ctg acc gtt gcc gtc ctc aac ggc        960
Gly Thr Ser Phe Trp Gly Thr Asn Leu Thr Val Ala Val Leu Asn Gly           
305                 310                 315                 320           

agc atc ccc gaa tgg cgt gtc gat gac atg gcc gtc cgt atc atg tct       1008
Ser Ile Pro Glu Trp Arg Val Asp Asp Met Ala Val Arg Ile Met Ser           
                325                 330                 335               

gcc tac tac aag gtc ggt cgt gac cgc tac tcc gtc ccc atc aac ttc       1056
Ala Tyr Tyr Lys Val Gly Arg Asp Arg Tyr Ser Val Pro Ile Asn Phe           
            340                 345                 350                   

gac agc tgg acc ctc gac acc tac ggc cct gag cac tac gcc gtc ggc       1104
Asp Ser Trp Thr Leu Asp Thr Tyr Gly Pro Glu His Tyr Ala Val Gly           
        355                 360                 365                       

cag ggt cag acc aag atc aac gag cac gtt gat gtc cgt ggc aac cac       1152
Gln Gly Gln Thr Lys Ile Asn Glu His Val Asp Val Arg Gly Asn His           
    370                 375                 380                           

gct gag atc atc cac gag atc ggt gct gcc tcc gcc gtc ctc ctc aag       1200
Ala Glu Ile Ile His Glu Ile Gly Ala Ala Ser Ala Val Leu Leu Lys           
385                 390                 395                 400           

aac aag ggt ggt ctg ccc ttg act ggt act gag cgc ttc gtc ggt gtg       1248
Asn Lys Gly Gly Leu Pro Leu Thr Gly Thr Glu Arg Phe Val Gly Val           
                405                 410                 415               

ttc ggc aag gat gcc ggt tcc aac ccc tgg ggt gtc aac ggc tgc tcc       1296
Phe Gly Lys Asp Ala Gly Ser Asn Pro Trp Gly Val Asn Gly Cys Ser           
            420                 425                 430                   

gac cgt ggc tgc gac aac ggc acc ctc gcc atg ggc tgg ggc agc ggt       1344
Asp Arg Gly Cys Asp Asn Gly Thr Leu Ala Met Gly Trp Gly Ser Gly           
        435                 440                 445                       

act gcc aac ttc ccc tac ctg gtc acc ccc gag cag gcc atc cag cgt       1392
Thr Ala Asn Phe Pro Tyr Leu Val Thr Pro Glu Gln Ala Ile Gln Arg           
    450                 455                 460                           

gag gtc ctt tct cgc aac ggc acc ttc act ggt atc acc gac aac ggt       1440
Glu Val Leu Ser Arg Asn Gly Thr Phe Thr Gly Ile Thr Asp Asn Gly           
465                 470                 475                 480           

gct ctt gct gag atg gct gct gct gcc tcc cag gcc gac acc tgc ctg       1488
Ala Leu Ala Glu Met Ala Ala Ala Ala Ser Gln Ala Asp Thr Cys Leu           
                485                 490                 495               

gtc ttt gcc aac gcc gac agc ggt gag ggc tac atc acc gtt gac ggc       1536
Val Phe Ala Asn Ala Asp Ser Gly Glu Gly Tyr Ile Thr Val Asp Gly           
            500                 505                 510                   

aac gag ggt gac cgc aag aac ctg acc ctc tgg cag ggt gcc gac cag       1584
Asn Glu Gly Asp Arg Lys Asn Leu Thr Leu Trp Gln Gly Ala Asp Gln           
        515                 520                 525                       

gtc atc cac aac gtt tcc gcc aac tgc aac aac act gtt gtt gtc ctc       1632
Val Ile His Asn Val Ser Ala Asn Cys Asn Asn Thr Val Val Val Leu           
    530                 535                 540                           

cac acc gtc ggt cct gtc ctg att gat gac tgg tac gac cac ccc aac       1680
His Thr Val Gly Pro Val Leu Ile Asp Asp Trp Tyr Asp His Pro Asn           
545                 550                 555                 560           

gtc act gcc atc ctc tgg gct ggt ctg ccc ggt cag gag tcc ggc aac       1728
Val Thr Ala Ile Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn           
                565                 570                 575               

tcg cta gtt gat gtc ctc tac ggc cgt gtc aac ccc ggc aag act ccc       1776
Ser Leu Val Asp Val Leu Tyr Gly Arg Val Asn Pro Gly Lys Thr Pro           
            580                 585                 590                   

ttc acc tgg ggt cgt gct cgt gat gac tac ggt gct cct ctg att gtc       1824
Phe Thr Trp Gly Arg Ala Arg Asp Asp Tyr Gly Ala Pro Leu Ile Val           
        595                 600                 605                       

aag ccc aac aac ggc aag ggt gct cct cag cag gac ttc acc gag ggt       1872
Lys Pro Asn Asn Gly Lys Gly Ala Pro Gln Gln Asp Phe Thr Glu Gly           
    610                 615                 620                           

atc ttc att gac tac cgc cgc ttc gac aag tac aac atc acc ccc atc       1920
Ile Phe Ile Asp Tyr Arg Arg Phe Asp Lys Tyr Asn Ile Thr Pro Ile           
625                 630                 635                 640           

tac gag ttc ggt ttc ggt ctg agc tac acc acc ttc gag ttc tcc cag       1968
Tyr Glu Phe Gly Phe Gly Leu Ser Tyr Thr Thr Phe Glu Phe Ser Gln           
                645                 650                 655               

ctc aac gtc cag ccc atc aac gct cct ccc tac act ccc gcc tcc ggt       2016
Leu Asn Val Gln Pro Ile Asn Ala Pro Pro Tyr Thr Pro Ala Ser Gly           
            660                 665                 670                   

ttc acc aag gct gct cag tcc ttc ggc cag ccc tcc aac gcc tcc gac       2064
Phe Thr Lys Ala Ala Gln Ser Phe Gly Gln Pro Ser Asn Ala Ser Asp           
        675                 680                 685                       

aac ctc tac ccc tcc gac att gag cgt gtt cct ctg tac atc tac ccc       2112
Asn Leu Tyr Pro Ser Asp Ile Glu Arg Val Pro Leu Tyr Ile Tyr Pro           
    690                 695                 700                           

tgg ctc aac agc act gac ctc aag gcc tct gcc aac gac ccc gac tac       2160
Trp Leu Asn Ser Thr Asp Leu Lys Ala Ser Ala Asn Asp Pro Asp Tyr           
705                 710                 715                 720           

ggc ctt cct act gag aag tac gtg cct ccc aac gcc acc aac ggt gac       2208
Gly Leu Pro Thr Glu Lys Tyr Val Pro Pro Asn Ala Thr Asn Gly Asp           
                725                 730                 735               

ccc cag ccc att gac cct gct ggt ggt gct cct ggt ggc aac ccc tcc       2256
Pro Gln Pro Ile Asp Pro Ala Gly Gly Ala Pro Gly Gly Asn Pro Ser           
            740                 745                 750                   

ctc tac gag cct gtt gct cgt gtc acc acc atc atc acc aac act ggc       2304
Leu Tyr Glu Pro Val Ala Arg Val Thr Thr Ile Ile Thr Asn Thr Gly           
        755                 760                 765                       

aag gtc act ggt gat gag gtt cct cag ctc tac gtc agc ctt ggt ggt       2352
Lys Val Thr Gly Asp Glu Val Pro Gln Leu Tyr Val Ser Leu Gly Gly           
    770                 775                 780                           

ccc gat gat gct ccc aag gtc ctc cgt ggt ttc gac cgt atc acc ctg       2400
Pro Asp Asp Ala Pro Lys Val Leu Arg Gly Phe Asp Arg Ile Thr Leu           
785                 790                 795                 800           

gct cct ggc cag cag tac ctc tgg acc acc acc ctc acc cgc cgt gac       2448
Ala Pro Gly Gln Gln Tyr Leu Trp Thr Thr Thr Leu Thr Arg Arg Asp           
                805                 810                 815               

atc tcc aac tgg gac ccc gtc acc cag aac tgg gtt gtc acc aac tac       2496
Ile Ser Asn Trp Asp Pro Val Thr Gln Asn Trp Val Val Thr Asn Tyr           
            820                 825                 830                   

acc aag acc atc tac gtc ggc aac agc tct cgc aac ctg ccc ctc cag       2544
Thr Lys Thr Ile Tyr Val Gly Asn Ser Ser Arg Asn Leu Pro Leu Gln           
        835                 840                 845                       

gct cct ctc aag ccc tac ccc ggc ata taa                               2574
Ala Pro Leu Lys Pro Tyr Pro Gly Ile                                       
    850                 855                                               


<210>  2
<211>  857
<212>  PRT
<213>  Talaromyces emersonii

<400>  2

Met Arg Asn Gly Leu Leu Lys Val Ala Ala Leu Ala Ala Ala Ser Ala 
1               5                   10                  15      


Val Asn Gly Glu Asn Leu Ala Tyr Ser Pro Pro Phe Tyr Pro Ser Pro 
            20                  25                  30          


Trp Ala Asn Gly Gln Gly Asp Trp Ala Glu Ala Tyr Gln Lys Ala Val 
        35                  40                  45              


Gln Phe Val Ser Gln Leu Thr Leu Ala Glu Lys Val Asn Leu Thr Thr 
    50                  55                  60                  


Gly Thr Gly Trp Glu Gln Asp Arg Cys Val Gly Gln Val Gly Ser Ile 
65                  70                  75                  80  


Pro Arg Leu Gly Phe Pro Gly Leu Cys Met Gln Asp Ser Pro Leu Gly 
                85                  90                  95      


Val Arg Asp Thr Asp Tyr Asn Ser Ala Phe Pro Ala Gly Val Asn Val 
            100                 105                 110         


Ala Ala Thr Trp Asp Arg Asn Leu Ala Tyr Arg Arg Gly Val Ala Met 
        115                 120                 125             


Gly Glu Glu His Arg Gly Lys Gly Val Asp Val Gln Leu Gly Pro Val 
    130                 135                 140                 


Ala Gly Pro Leu Gly Arg Ser Pro Asp Ala Gly Arg Asn Trp Glu Gly 
145                 150                 155                 160 


Phe Ala Pro Asp Pro Val Leu Thr Gly Asn Met Met Ala Ser Thr Ile 
                165                 170                 175     


Gln Gly Ile Gln Asp Ala Gly Val Ile Ala Cys Ala Lys His Phe Ile 
            180                 185                 190         


Leu Tyr Glu Gln Glu His Phe Arg Gln Gly Ala Gln Asp Gly Tyr Asp 
        195                 200                 205             


Ile Ser Asp Ser Ile Ser Ala Asn Ala Asp Asp Lys Thr Met His Glu 
    210                 215                 220                 


Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser 
225                 230                 235                 240 


Val Met Cys Ser Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Ser Asn 
                245                 250                 255     


Ser Tyr Thr Met Asn Lys Leu Leu Lys Ser Glu Leu Gly Phe Gln Gly 
            260                 265                 270         


Phe Val Met Thr Asp Trp Gly Gly His His Ser Gly Val Gly Ser Ala 
        275                 280                 285             


Leu Ala Gly Leu Asp Met Ser Met Pro Gly Asp Ile Ala Phe Asp Ser 
    290                 295                 300                 


Gly Thr Ser Phe Trp Gly Thr Asn Leu Thr Val Ala Val Leu Asn Gly 
305                 310                 315                 320 


Ser Ile Pro Glu Trp Arg Val Asp Asp Met Ala Val Arg Ile Met Ser 
                325                 330                 335     


Ala Tyr Tyr Lys Val Gly Arg Asp Arg Tyr Ser Val Pro Ile Asn Phe 
            340                 345                 350         


Asp Ser Trp Thr Leu Asp Thr Tyr Gly Pro Glu His Tyr Ala Val Gly 
        355                 360                 365             


Gln Gly Gln Thr Lys Ile Asn Glu His Val Asp Val Arg Gly Asn His 
    370                 375                 380                 


Ala Glu Ile Ile His Glu Ile Gly Ala Ala Ser Ala Val Leu Leu Lys 
385                 390                 395                 400 


Asn Lys Gly Gly Leu Pro Leu Thr Gly Thr Glu Arg Phe Val Gly Val 
                405                 410                 415     


Phe Gly Lys Asp Ala Gly Ser Asn Pro Trp Gly Val Asn Gly Cys Ser 
            420                 425                 430         


Asp Arg Gly Cys Asp Asn Gly Thr Leu Ala Met Gly Trp Gly Ser Gly 
        435                 440                 445             


Thr Ala Asn Phe Pro Tyr Leu Val Thr Pro Glu Gln Ala Ile Gln Arg 
    450                 455                 460                 


Glu Val Leu Ser Arg Asn Gly Thr Phe Thr Gly Ile Thr Asp Asn Gly 
465                 470                 475                 480 


Ala Leu Ala Glu Met Ala Ala Ala Ala Ser Gln Ala Asp Thr Cys Leu 
                485                 490                 495     


Val Phe Ala Asn Ala Asp Ser Gly Glu Gly Tyr Ile Thr Val Asp Gly 
            500                 505                 510         


Asn Glu Gly Asp Arg Lys Asn Leu Thr Leu Trp Gln Gly Ala Asp Gln 
        515                 520                 525             


Val Ile His Asn Val Ser Ala Asn Cys Asn Asn Thr Val Val Val Leu 
    530                 535                 540                 


His Thr Val Gly Pro Val Leu Ile Asp Asp Trp Tyr Asp His Pro Asn 
545                 550                 555                 560 


Val Thr Ala Ile Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn 
                565                 570                 575     


Ser Leu Val Asp Val Leu Tyr Gly Arg Val Asn Pro Gly Lys Thr Pro 
            580                 585                 590         


Phe Thr Trp Gly Arg Ala Arg Asp Asp Tyr Gly Ala Pro Leu Ile Val 
        595                 600                 605             


Lys Pro Asn Asn Gly Lys Gly Ala Pro Gln Gln Asp Phe Thr Glu Gly 
    610                 615                 620                 


Ile Phe Ile Asp Tyr Arg Arg Phe Asp Lys Tyr Asn Ile Thr Pro Ile 
625                 630                 635                 640 


Tyr Glu Phe Gly Phe Gly Leu Ser Tyr Thr Thr Phe Glu Phe Ser Gln 
                645                 650                 655     


Leu Asn Val Gln Pro Ile Asn Ala Pro Pro Tyr Thr Pro Ala Ser Gly 
            660                 665                 670         


Phe Thr Lys Ala Ala Gln Ser Phe Gly Gln Pro Ser Asn Ala Ser Asp 
        675                 680                 685             


Asn Leu Tyr Pro Ser Asp Ile Glu Arg Val Pro Leu Tyr Ile Tyr Pro 
    690                 695                 700                 


Trp Leu Asn Ser Thr Asp Leu Lys Ala Ser Ala Asn Asp Pro Asp Tyr 
705                 710                 715                 720 


Gly Leu Pro Thr Glu Lys Tyr Val Pro Pro Asn Ala Thr Asn Gly Asp 
                725                 730                 735     


Pro Gln Pro Ile Asp Pro Ala Gly Gly Ala Pro Gly Gly Asn Pro Ser 
            740                 745                 750         


Leu Tyr Glu Pro Val Ala Arg Val Thr Thr Ile Ile Thr Asn Thr Gly 
        755                 760                 765             


Lys Val Thr Gly Asp Glu Val Pro Gln Leu Tyr Val Ser Leu Gly Gly 
    770                 775                 780                 


Pro Asp Asp Ala Pro Lys Val Leu Arg Gly Phe Asp Arg Ile Thr Leu 
785                 790                 795                 800 


Ala Pro Gly Gln Gln Tyr Leu Trp Thr Thr Thr Leu Thr Arg Arg Asp 
                805                 810                 815     


Ile Ser Asn Trp Asp Pro Val Thr Gln Asn Trp Val Val Thr Asn Tyr 
            820                 825                 830         


Thr Lys Thr Ile Tyr Val Gly Asn Ser Ser Arg Asn Leu Pro Leu Gln 
        835                 840                 845             


Ala Pro Leu Lys Pro Tyr Pro Gly Ile 
    850                 855         


<210>  3
<211>  2577
<212>  DNA
<213>  Talaromyces emersonii


<220>
<221>  CDS
<222>  (1)..(2577)

<400>  3
atg agg aac ggg ttg ctc aag gtc gcc gcc ctt gcg gcc gct tcg gtc         48
Met Arg Asn Gly Leu Leu Lys Val Ala Ala Leu Ala Ala Ala Ser Val           
1               5                   10                  15                

gtc aat ggc gag aac ctg gct tat tca cct ccc ttc tac cct tcg ccg         96
Val Asn Gly Glu Asn Leu Ala Tyr Ser Pro Pro Phe Tyr Pro Ser Pro           
            20                  25                  30                    

tgg gcc aat gga cag ggc gac tgg gca gag gcc tac gag aag gcc gtc        144
Trp Ala Asn Gly Gln Gly Asp Trp Ala Glu Ala Tyr Glu Lys Ala Val           
        35                  40                  45                        

aag ttt gtc tcc caa ctc acg ctg gcc gaa aag gtc aac ctg acc acc        192
Lys Phe Val Ser Gln Leu Thr Leu Ala Glu Lys Val Asn Leu Thr Thr           
    50                  55                  60                            

gga act ggt tgg gag cag gac cga tgc gtc ggc caa gtg ggt agc atc        240
Gly Thr Gly Trp Glu Gln Asp Arg Cys Val Gly Gln Val Gly Ser Ile           
65                  70                  75                  80            

cca aga ttg ggc ttc cca gga ctt tgc atg cag gac tct ccg ctg ggt        288
Pro Arg Leu Gly Phe Pro Gly Leu Cys Met Gln Asp Ser Pro Leu Gly           
                85                  90                  95                

gtt cga gac act gac tac aac tcg gcc ttc ccg gcg ggt gtc aat gtc        336
Val Arg Asp Thr Asp Tyr Asn Ser Ala Phe Pro Ala Gly Val Asn Val           
            100                 105                 110                   

gct gct acc tgg aac agg gac ctc gcc tac cgt cgc ggc caa gcg atg        384
Ala Ala Thr Trp Asn Arg Asp Leu Ala Tyr Arg Arg Gly Gln Ala Met           
        115                 120                 125                       

ggc gag gag cat cgc gga aaa ggt gtc gac gtt cag ctg ggc cct gtg        432
Gly Glu Glu His Arg Gly Lys Gly Val Asp Val Gln Leu Gly Pro Val           
    130                 135                 140                           

gcc ggc ccg ctg ggc agg tct ccc gat gct ggc aga aac tgg gaa ggt        480
Ala Gly Pro Leu Gly Arg Ser Pro Asp Ala Gly Arg Asn Trp Glu Gly           
145                 150                 155                 160           

ttc gcc ccg gat ccc gtg ctg acc gga aac atg atg gcg tcc acc atc        528
Phe Ala Pro Asp Pro Val Leu Thr Gly Asn Met Met Ala Ser Thr Ile           
                165                 170                 175               

cag ggt att caa gat gct ggt gtc att gct tgc gcc aag cat ttc atc        576
Gln Gly Ile Gln Asp Ala Gly Val Ile Ala Cys Ala Lys His Phe Ile           
            180                 185                 190                   

ctc tac gag cag gag cat ttc cgt cag ggc gct caa gat ggc tac gat        624
Leu Tyr Glu Gln Glu His Phe Arg Gln Gly Ala Gln Asp Gly Tyr Asp           
        195                 200                 205                       

atc tcc gac agt atc agt gcc aac gcc gat gac aag act atg cac gag        672
Ile Ser Asp Ser Ile Ser Ala Asn Ala Asp Asp Lys Thr Met His Glu           
    210                 215                 220                           

ttg tac ttg tgg cct ttt gcc gat gct gtt cgc gct ggc gtt ggt tca        720
Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser           
225                 230                 235                 240           

atc atg tgc tcc tac aac cag gtg aac aac agc tac gcc tgc tcc aac        768
Ile Met Cys Ser Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Ser Asn           
                245                 250                 255               

agc tac acc atg aac aag ctg ctc aag agc gaa ttg ggc ttc caa ggc        816
Ser Tyr Thr Met Asn Lys Leu Leu Lys Ser Glu Leu Gly Phe Gln Gly           
            260                 265                 270                   

ttc gtc atg acc gac tgg ggt ggc cac cac agt ggt gtg ggt tcc gct        864
Phe Val Met Thr Asp Trp Gly Gly His His Ser Gly Val Gly Ser Ala           
        275                 280                 285                       

ctc gct ggt ttg gac atg tcg atg ccc gga gac att gcc ttc gac agt        912
Leu Ala Gly Leu Asp Met Ser Met Pro Gly Asp Ile Ala Phe Asp Ser           
    290                 295                 300                           

ggc acc tcc ttc tgg ggc act aac ctc acg gtt gcc gtg ctc aat gga        960
Gly Thr Ser Phe Trp Gly Thr Asn Leu Thr Val Ala Val Leu Asn Gly           
305                 310                 315                 320           

agt gtt cct gag tgg cgt gtt gat gac atg gct gtc cgt atc atg tcc       1008
Ser Val Pro Glu Trp Arg Val Asp Asp Met Ala Val Arg Ile Met Ser           
                325                 330                 335               

gct tat tac aag gtc ggc cgc gac cgc tac agc gtc ccc atc aac ttt       1056
Ala Tyr Tyr Lys Val Gly Arg Asp Arg Tyr Ser Val Pro Ile Asn Phe           
            340                 345                 350                   

gac tcg tgg acc ctg gat acc tat ggt ccc gag cac tat gcg gtg ggc       1104
Asp Ser Trp Thr Leu Asp Thr Tyr Gly Pro Glu His Tyr Ala Val Gly           
        355                 360                 365                       

cag ggc aac acc aag atc aac gag cac gtt gat gtt cgc ggc aac cat       1152
Gln Gly Asn Thr Lys Ile Asn Glu His Val Asp Val Arg Gly Asn His           
    370                 375                 380                           

gca gaa atc atc cat gaa atc ggt gct gcc agc gcc gtc ctt ctc aag       1200
Ala Glu Ile Ile His Glu Ile Gly Ala Ala Ser Ala Val Leu Leu Lys           
385                 390                 395                 400           

aac aag ggt ggg ctt cct ttg act ggc acc gaa cgg ttt gtc ggt gtt       1248
Asn Lys Gly Gly Leu Pro Leu Thr Gly Thr Glu Arg Phe Val Gly Val           
                405                 410                 415               

ttc gga gag gat gcc gga tcc aac cct tgg ggt gtg aac ggc tgc agt       1296
Phe Gly Glu Asp Ala Gly Ser Asn Pro Trp Gly Val Asn Gly Cys Ser           
            420                 425                 430                   

gac cga ggc tgc gac aat ggt aca ttg gcc atg ggc tgg ggc agt ggt       1344
Asp Arg Gly Cys Asp Asn Gly Thr Leu Ala Met Gly Trp Gly Ser Gly           
        435                 440                 445                       

act gct aac ttc ccc tac ttg gtg acg ccg gag cag gcg atc gag aga       1392
Thr Ala Asn Phe Pro Tyr Leu Val Thr Pro Glu Gln Ala Ile Glu Arg           
    450                 455                 460                           

gaa gtc gtg tcc cga aat gga acc ttc acc gcc atc acg gac aat ggc       1440
Glu Val Val Ser Arg Asn Gly Thr Phe Thr Ala Ile Thr Asp Asn Gly           
465                 470                 475                 480           

gct ctt gag cag atg gcg gct gtc gcc tct cag gct gat gtt tgc ctg       1488
Ala Leu Glu Gln Met Ala Ala Val Ala Ser Gln Ala Asp Val Cys Leu           
                485                 490                 495               

gtc ttc gcc aac gcc gac tcc gga gaa ggc tac atc aac gtc gac ggc       1536
Val Phe Ala Asn Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly           
            500                 505                 510                   

aat gag ggt gac cgg aag aat ctg acc ctg tgg caa ggg gcg gat caa       1584
Asn Glu Gly Asp Arg Lys Asn Leu Thr Leu Trp Gln Gly Ala Asp Gln           
        515                 520                 525                       

gtc atc cac aac gtc act gcc aac tgc aac aac acc gtc gtg gtg ttg       1632
Val Ile His Asn Val Thr Ala Asn Cys Asn Asn Thr Val Val Val Leu           
    530                 535                 540                           

cac act gtc ggc ccc gtt ttg atc gat gat tgg tat gac cac ccc aac       1680
His Thr Val Gly Pro Val Leu Ile Asp Asp Trp Tyr Asp His Pro Asn           
545                 550                 555                 560           

gtc act gcc att ctc tgg gct ggt ctt ccg ggc cag gag agc ggt aac       1728
Val Thr Ala Ile Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn           
                565                 570                 575               

tcg ctc gtc gat gtc ctc tac ggc cgt gtc aac cct ggc gga aag act       1776
Ser Leu Val Asp Val Leu Tyr Gly Arg Val Asn Pro Gly Gly Lys Thr           
            580                 585                 590                   

ccg ttc acc tgg gga cgg acc cgg gag gat tac ggt gct cct ctg gtc       1824
Pro Phe Thr Trp Gly Arg Thr Arg Glu Asp Tyr Gly Ala Pro Leu Val           
        595                 600                 605                       

ctg aag ccg aac aat ggc aag ggc gcc ccg cag cag gac ttc act gag       1872
Leu Lys Pro Asn Asn Gly Lys Gly Ala Pro Gln Gln Asp Phe Thr Glu           
    610                 615                 620                           

ggt atc ttc atc gac tac cgt cgg ttt gac aag tac aac atc acc ccc       1920
Gly Ile Phe Ile Asp Tyr Arg Arg Phe Asp Lys Tyr Asn Ile Thr Pro           
625                 630                 635                 640           

atc tac gaa ttc gga ttc ggt ctg agc tac act acc ttt gag ttt tct       1968
Ile Tyr Glu Phe Gly Phe Gly Leu Ser Tyr Thr Thr Phe Glu Phe Ser           
                645                 650                 655               

gag ctc aat gtg cag cct atc aat acg ccg ccg tac act ccc gct tct       2016
Glu Leu Asn Val Gln Pro Ile Asn Thr Pro Pro Tyr Thr Pro Ala Ser           
            660                 665                 670                   

ggc ttc acc aag gcg gcg cag tca ttc ggc ccg tcg tcc aat gct tct       2064
Gly Phe Thr Lys Ala Ala Gln Ser Phe Gly Pro Ser Ser Asn Ala Ser           
        675                 680                 685                       

gac aac ctg tac ccc agc gac att gag cgg gtc ccg ttg tac atc tac       2112
Asp Asn Leu Tyr Pro Ser Asp Ile Glu Arg Val Pro Leu Tyr Ile Tyr           
    690                 695                 700                           

cca tgg ctc aac tcc acc gat ttg aag gcg tcc gcc aat gac cct gac       2160
Pro Trp Leu Asn Ser Thr Asp Leu Lys Ala Ser Ala Asn Asp Pro Asp           
705                 710                 715                 720           

tat ggg ttg cct aac gac aaa tac gtt cct ccc aac gcc acg aac ggt       2208
Tyr Gly Leu Pro Asn Asp Lys Tyr Val Pro Pro Asn Ala Thr Asn Gly           
                725                 730                 735               

aac ccg cag ccc att aac ccg gct ggc ggt gct cct ggt ggc aac cct       2256
Asn Pro Gln Pro Ile Asn Pro Ala Gly Gly Ala Pro Gly Gly Asn Pro           
            740                 745                 750                   

agt ctc tat gag cct gtt gct cgg gtc tca gcc atc atc acc aac acc       2304
Ser Leu Tyr Glu Pro Val Ala Arg Val Ser Ala Ile Ile Thr Asn Thr           
        755                 760                 765                       

ggt aag gtt acg ggt gac gag gtt cct caa ctg tat gtc tct ctt ggc       2352
Gly Lys Val Thr Gly Asp Glu Val Pro Gln Leu Tyr Val Ser Leu Gly           
    770                 775                 780                           

ggt ccc gat gat gcc ccc aag gtt ctt cgt ggc ttc gac cgt atc aca       2400
Gly Pro Asp Asp Ala Pro Lys Val Leu Arg Gly Phe Asp Arg Ile Thr           
785                 790                 795                 800           

ctt gcg cct ggt cag cag acc ttg tgg acg acc acc ctg acg agg cga       2448
Leu Ala Pro Gly Gln Gln Thr Leu Trp Thr Thr Thr Leu Thr Arg Arg           
                805                 810                 815               

gac atc tcg aac tgg gac cct gtc acc cag aac tgg gtt gtg acc aac       2496
Asp Ile Ser Asn Trp Asp Pro Val Thr Gln Asn Trp Val Val Thr Asn           
            820                 825                 830                   

tac acc aag acg gtg tat gtt ggc aac tcc tcc cgc aac ctg cct ttg       2544
Tyr Thr Lys Thr Val Tyr Val Gly Asn Ser Ser Arg Asn Leu Pro Leu           
        835                 840                 845                       

cag gca ccc ctt aag cca tat cct gga atc taa                           2577
Gln Ala Pro Leu Lys Pro Tyr Pro Gly Ile                                   
    850                 855                                               


<210>  4
<211>  858
<212>  PRT
<213>  Talaromyces emersonii

<400>  4

Met Arg Asn Gly Leu Leu Lys Val Ala Ala Leu Ala Ala Ala Ser Val 
1               5                   10                  15      


Val Asn Gly Glu Asn Leu Ala Tyr Ser Pro Pro Phe Tyr Pro Ser Pro 
            20                  25                  30          


Trp Ala Asn Gly Gln Gly Asp Trp Ala Glu Ala Tyr Glu Lys Ala Val 
        35                  40                  45              


Lys Phe Val Ser Gln Leu Thr Leu Ala Glu Lys Val Asn Leu Thr Thr 
    50                  55                  60                  


Gly Thr Gly Trp Glu Gln Asp Arg Cys Val Gly Gln Val Gly Ser Ile 
65                  70                  75                  80  


Pro Arg Leu Gly Phe Pro Gly Leu Cys Met Gln Asp Ser Pro Leu Gly 
                85                  90                  95      


Val Arg Asp Thr Asp Tyr Asn Ser Ala Phe Pro Ala Gly Val Asn Val 
            100                 105                 110         


Ala Ala Thr Trp Asn Arg Asp Leu Ala Tyr Arg Arg Gly Gln Ala Met 
        115                 120                 125             


Gly Glu Glu His Arg Gly Lys Gly Val Asp Val Gln Leu Gly Pro Val 
    130                 135                 140                 


Ala Gly Pro Leu Gly Arg Ser Pro Asp Ala Gly Arg Asn Trp Glu Gly 
145                 150                 155                 160 


Phe Ala Pro Asp Pro Val Leu Thr Gly Asn Met Met Ala Ser Thr Ile 
                165                 170                 175     


Gln Gly Ile Gln Asp Ala Gly Val Ile Ala Cys Ala Lys His Phe Ile 
            180                 185                 190         


Leu Tyr Glu Gln Glu His Phe Arg Gln Gly Ala Gln Asp Gly Tyr Asp 
        195                 200                 205             


Ile Ser Asp Ser Ile Ser Ala Asn Ala Asp Asp Lys Thr Met His Glu 
    210                 215                 220                 


Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser 
225                 230                 235                 240 


Ile Met Cys Ser Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Ser Asn 
                245                 250                 255     


Ser Tyr Thr Met Asn Lys Leu Leu Lys Ser Glu Leu Gly Phe Gln Gly 
            260                 265                 270         


Phe Val Met Thr Asp Trp Gly Gly His His Ser Gly Val Gly Ser Ala 
        275                 280                 285             


Leu Ala Gly Leu Asp Met Ser Met Pro Gly Asp Ile Ala Phe Asp Ser 
    290                 295                 300                 


Gly Thr Ser Phe Trp Gly Thr Asn Leu Thr Val Ala Val Leu Asn Gly 
305                 310                 315                 320 


Ser Val Pro Glu Trp Arg Val Asp Asp Met Ala Val Arg Ile Met Ser 
                325                 330                 335     


Ala Tyr Tyr Lys Val Gly Arg Asp Arg Tyr Ser Val Pro Ile Asn Phe 
            340                 345                 350         


Asp Ser Trp Thr Leu Asp Thr Tyr Gly Pro Glu His Tyr Ala Val Gly 
        355                 360                 365             


Gln Gly Asn Thr Lys Ile Asn Glu His Val Asp Val Arg Gly Asn His 
    370                 375                 380                 


Ala Glu Ile Ile His Glu Ile Gly Ala Ala Ser Ala Val Leu Leu Lys 
385                 390                 395                 400 


Asn Lys Gly Gly Leu Pro Leu Thr Gly Thr Glu Arg Phe Val Gly Val 
                405                 410                 415     


Phe Gly Glu Asp Ala Gly Ser Asn Pro Trp Gly Val Asn Gly Cys Ser 
            420                 425                 430         


Asp Arg Gly Cys Asp Asn Gly Thr Leu Ala Met Gly Trp Gly Ser Gly 
        435                 440                 445             


Thr Ala Asn Phe Pro Tyr Leu Val Thr Pro Glu Gln Ala Ile Glu Arg 
    450                 455                 460                 


Glu Val Val Ser Arg Asn Gly Thr Phe Thr Ala Ile Thr Asp Asn Gly 
465                 470                 475                 480 


Ala Leu Glu Gln Met Ala Ala Val Ala Ser Gln Ala Asp Val Cys Leu 
                485                 490                 495     


Val Phe Ala Asn Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly 
            500                 505                 510         


Asn Glu Gly Asp Arg Lys Asn Leu Thr Leu Trp Gln Gly Ala Asp Gln 
        515                 520                 525             


Val Ile His Asn Val Thr Ala Asn Cys Asn Asn Thr Val Val Val Leu 
    530                 535                 540                 


His Thr Val Gly Pro Val Leu Ile Asp Asp Trp Tyr Asp His Pro Asn 
545                 550                 555                 560 


Val Thr Ala Ile Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn 
                565                 570                 575     


Ser Leu Val Asp Val Leu Tyr Gly Arg Val Asn Pro Gly Gly Lys Thr 
            580                 585                 590         


Pro Phe Thr Trp Gly Arg Thr Arg Glu Asp Tyr Gly Ala Pro Leu Val 
        595                 600                 605             


Leu Lys Pro Asn Asn Gly Lys Gly Ala Pro Gln Gln Asp Phe Thr Glu 
    610                 615                 620                 


Gly Ile Phe Ile Asp Tyr Arg Arg Phe Asp Lys Tyr Asn Ile Thr Pro 
625                 630                 635                 640 


Ile Tyr Glu Phe Gly Phe Gly Leu Ser Tyr Thr Thr Phe Glu Phe Ser 
                645                 650                 655     


Glu Leu Asn Val Gln Pro Ile Asn Thr Pro Pro Tyr Thr Pro Ala Ser 
            660                 665                 670         


Gly Phe Thr Lys Ala Ala Gln Ser Phe Gly Pro Ser Ser Asn Ala Ser 
        675                 680                 685             


Asp Asn Leu Tyr Pro Ser Asp Ile Glu Arg Val Pro Leu Tyr Ile Tyr 
    690                 695                 700                 


Pro Trp Leu Asn Ser Thr Asp Leu Lys Ala Ser Ala Asn Asp Pro Asp 
705                 710                 715                 720 


Tyr Gly Leu Pro Asn Asp Lys Tyr Val Pro Pro Asn Ala Thr Asn Gly 
                725                 730                 735     


Asn Pro Gln Pro Ile Asn Pro Ala Gly Gly Ala Pro Gly Gly Asn Pro 
            740                 745                 750         


Ser Leu Tyr Glu Pro Val Ala Arg Val Ser Ala Ile Ile Thr Asn Thr 
        755                 760                 765             


Gly Lys Val Thr Gly Asp Glu Val Pro Gln Leu Tyr Val Ser Leu Gly 
    770                 775                 780                 


Gly Pro Asp Asp Ala Pro Lys Val Leu Arg Gly Phe Asp Arg Ile Thr 
785                 790                 795                 800 


Leu Ala Pro Gly Gln Gln Thr Leu Trp Thr Thr Thr Leu Thr Arg Arg 
                805                 810                 815     


Asp Ile Ser Asn Trp Asp Pro Val Thr Gln Asn Trp Val Val Thr Asn 
            820                 825                 830         


Tyr Thr Lys Thr Val Tyr Val Gly Asn Ser Ser Arg Asn Leu Pro Leu 
        835                 840                 845             


Gln Ala Pro Leu Lys Pro Tyr Pro Gly Ile 
    850                 855             


