                         SEQUENCE LISTING

<110>  UNIVERSITE D'AIX MARSEILLE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       CRENON-CONSTARATAS, Isabelle
       MARTINEZ, Emmanuelle
       SILVY, Franoise
       MAS, Eric
       OUAISSI, Mehdi
       LOMBARDO, Dominique
 
<120>  Diagnosis method of pancreatic cancer

<130>  F2245-19 PCT

<150>  EP 15198300.4
<151>  2015-12-07

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  human

<400>  1
tcttctcact ctgcagggac c                                                 21


<210>  2
<211>  22
<212>  DNA
<213>  human

<400>  2
caggggtatg aggctttatt ca                                                22


<210>  3
<211>  20
<212>  DNA
<213>  human

<400>  3
gaaccaactt cctgcgctac                                                   20


<210>  4
<211>  2386
<212>  DNA
<213>  human

<400>  4
ggccacccag aggctgatgc tcaccatggg gcgcctgcaa ctggttgtgt tgggcctcac       60

ctgctgctgg gcagtggcga gtgccgcgaa gctgggcgcc gtgtacacag aaggtgggtt      120

cgtggaaggc gtcaataaga agctcggcct cctgggtgac tctgtggaca tcttcaaggg      180

catccccttc gcagctccca ccaaggccct ggaaaatcct cagccacatc ctggctggca      240

agggaccctg aaggccaaga acttcaagaa gagatgcctg caggccacca tcacccagga      300

cagcacctac ggggatgaag actgcctgta cctcaacatt tgggtgcccc agggcaggaa      360

gcaagtctcc cgggacctgc ccgttatgat ctggatctat ggaggcgcct tcctcatggg      420

gtccggccat ggggccaact tcctcaacaa ctacctgtat gacggcgagg agatcgccac      480

acgcggaaac gtcatcgtgg tcaccttcaa ctaccgtgtc ggcccccttg ggttcctcag      540

cactggggac gccaatctgc caggtaacta tggccttcgg gatcagcaca tggccattgc      600

ttgggtgaag aggaatatcg cggccttcgg gggggacccc aacaacatca cgctcttcgg      660

ggagtctgct ggaggtgcca gcgtctctct gcagaccctc tccccctaca acaagggcct      720

catccggcga gccatcagcc agagcggcgt ggccctgagt ccctgggtca tccagaaaaa      780

cccactcttc tgggccaaaa aggtggctga gaaggtgggt tgccctgtgg gtgatgccgc      840

caggatggcc cagtgtctga aggttactga tccccgagcc ctgacgctgg cctataaggt      900

gccgctggca ggcctggagt accccatgct gcactatgtg ggcttcgtcc ctgtcattga      960

tggagacttc atccccgctg acccgatcaa cctgtacgcc aacgccgccg acatcgacta     1020

tatagcaggc accaacaaca tggacggcca catcttcgcc agcatcgaca tgcctgccat     1080

caacaagggc aacaagaaag tcacggagga ggacttctac aagctggtca gtgagttcac     1140

aatcaccaag gggctcagag gcgccaagac gacctttgat gtctacaccg agtcctgggc     1200

ccaggaccca tcccaggaga ataagaagaa gactgtggtg gactttgaga ccgatgtcct     1260

cttcctggtg cccaccgaga ttgccctagc ccagcacaga gccaatgcca agagtgccaa     1320

gacctacgcc tacctgtttt cccatccctc tcggatgccc gtctacccca aatgggtggg     1380

ggccgaccat gcagatgaca ttcagtacgt tttcgggaag cccttcgcca cccccacggg     1440

ctaccggccc caagacagga cagtctctaa ggccatgatc gcctactgga ccaactttgc     1500

caaaacaggg gaccccaaca tgggcgactc ggctgtgccc acacactggg aaccctacac     1560

tacggaaaac agcggctacc tggagatcac caagaagatg ggcagcagct ccatgaagcg     1620

gagcctgaga accaacttcc tgcgctactg gaccctcacc tatctggcgc tgcccacagt     1680

gaccgaccag gaggccaccc ctgtgccccc cacaggggac tccgaggcca ctcccgtgcc     1740

ccccacgggt gactccgaga ccgcccccgt gccgcccacg ggtgactccg gggccccccc     1800

cgtgccgccc acgggtgact ccggggcccc ccccgtgccg cccacgggtg actccggggc     1860

cccccccgtg ccgcccacgg gtgactccgg ggcccccccc gtgccgccca cgggtgactc     1920

cggggccccc cccgtgccgc ccacgggtga ctccggggcc ccccccgtgc cgcccacggg     1980

tgactccggg gccccccccg tgccgcccac gggtgactcc ggcgcccccc ccgtgccgcc     2040

cacgggtgac gccgggcccc cccccgtgcc gcccacgggt gactccggcg ccccccccgt     2100

gccgcccacg ggtgactccg gggccccccc cgtgaccccc acgggtgact ccgagaccgc     2160

ccccgtgccg cccacgggtg actccggggc cccccctgtg ccccccacgg gtgactctga     2220

ggctgcccct gtgcccccca cagatgactc caaggaagct cagatgcctg cagtcattag     2280

gttttagcgt cccatgagcc ttggtatcaa gaggccacaa gagtgggacc ccaggggctc     2340

ccctcccatc ttgagctctt cctgaataaa gcctcatacc cctgtc                    2386


<210>  5
<211>  756
<212>  PRT
<213>  human

<400>  5

Met Leu Thr Met Gly Arg Leu Gln Leu Val Val Leu Gly Leu Thr Cys 
1               5                   10                  15      


Cys Trp Ala Val Ala Ser Ala Ala Lys Leu Gly Ala Val Tyr Thr Glu 
            20                  25                  30          


Gly Gly Phe Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly Asp 
        35                  40                  45              


Ser Val Asp Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys Ala 
    50                  55                  60                  


Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys Ala 
65                  70                  75                  80  


Lys Asn Phe Lys Lys Arg Cys Leu Gln Ala Thr Ile Thr Gln Asp Ser 
                85                  90                  95      


Thr Tyr Gly Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro Gln 
            100                 105                 110         


Gly Arg Lys Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile Tyr 
        115                 120                 125             


Gly Gly Ala Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu Asn 
    130                 135                 140                 


Asn Tyr Leu Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val Ile 
145                 150                 155                 160 


Val Val Thr Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser Thr 
                165                 170                 175     


Gly Asp Ala Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His Met 
            180                 185                 190         


Ala Ile Ala Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro 
        195                 200                 205             


Asn Asn Ile Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val Ser 
    210                 215                 220                 


Leu Gln Thr Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala Ile 
225                 230                 235                 240 


Ser Gln Ser Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn Pro 
                245                 250                 255     


Leu Phe Trp Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val Gly 
            260                 265                 270         


Asp Ala Ala Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg Ala 
        275                 280                 285             


Leu Thr Leu Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro Met 
    290                 295                 300                 


Leu His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile Pro 
305                 310                 315                 320 


Ala Asp Pro Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr Ile 
                325                 330                 335     


Ala Gly Thr Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp Met 
            340                 345                 350         


Pro Ala Ile Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe Tyr 
        355                 360                 365             


Lys Leu Val Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala Lys 
    370                 375                 380                 


Thr Thr Phe Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser Gln 
385                 390                 395                 400 


Glu Asn Lys Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu Phe 
                405                 410                 415     


Leu Val Pro Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala Lys 
            420                 425                 430         


Ser Ala Lys Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met Pro 
        435                 440                 445             


Val Tyr Pro Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln Tyr 
    450                 455                 460                 


Val Phe Gly Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln Asp 
465                 470                 475                 480 


Arg Thr Val Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala Lys 
                485                 490                 495     


Thr Gly Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu 
            500                 505                 510         


Pro Tyr Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met 
        515                 520                 525             


Gly Ser Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr 
    530                 535                 540                 


Trp Thr Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala 
545                 550                 555                 560 


Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro 
                565                 570                 575     


Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly 
            580                 585                 590         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        595                 600                 605             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    610                 615                 620                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
625                 630                 635                 640 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                645                 650                 655     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            660                 665                 670         


Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly 
        675                 680                 685             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    690                 695                 700                 


Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
705                 710                 715                 720 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
                725                 730                 735     


Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala 
            740                 745                 750         


Val Ile Arg Phe 
        755     


<210>  6
<211>  9
<212>  PRT
<213>  human

<400>  6

Gly Ala Pro Pro Arg Ala Ala His Gly 
1               5                   


<210>  7
<211>  12
<212>  PRT
<213>  human

<400>  7

Cys Lys Glu Ala Gln Met Pro Ala Val Ile Arg Phe 
1               5                   10          


<210>  8
<211>  247
<212>  PRT
<213>  human

<400>  8

Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr 
1               5                   10                  15      


Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser 
            20                  25                  30          


Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr 
        35                  40                  45              


Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro 
    50                  55                  60                  


Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly 
65                  70                  75                  80  


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                85                  90                  95      


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            100                 105                 110         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        115                 120                 125             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    130                 135                 140                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
145                 150                 155                 160 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro 
                165                 170                 175     


Pro Thr Gly Asp Ser Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
            180                 185                 190         


Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val 
        195                 200                 205             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    210                 215                 220                 


Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln 
225                 230                 235                 240 


Met Pro Ala Val Ile Arg Phe 
                245         


<210>  9
<211>  135
<212>  PRT
<213>  human

<400>  9

Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr 
1               5                   10                  15      


Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser 
            20                  25                  30          


Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr 
        35                  40                  45              


Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro 
    50                  55                  60                  


Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly 
65                  70                  75                  80  


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                85                  90                  95      


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            100                 105                 110         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        115                 120                 125             


Pro Pro Arg Ala Ala His Gly 
    130                 135 


<210>  10
<211>  122
<212>  PRT
<213>  human

<400>  10

Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr 
1               5                   10                  15      


Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser 
            20                  25                  30          


Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr 
        35                  40                  45              


Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro 
    50                  55                  60                  


Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly 
65                  70                  75                  80  


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                85                  90                  95      


Leu Cys Pro Pro Arg Val Thr Leu Arg Leu Pro Leu Cys Pro Pro Gln 
            100                 105                 110         


Met Thr Pro Arg Leu Asp Ala Cys Ser His 
        115                 120         


<210>  11
<211>  21
<212>  DNA
<213>  human

<400>  11
cctgcagtca ttaggtttta g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  human

<400>  12
ccccgtgccg cccacgggtg a                                                 21


<210>  13
<211>  773
<212>  DNA
<213>  human

<400>  13
ggaccccaac atgggcgact cggctgtgcc cacacactgg gaaccctaca ctacggaaaa       60

cagcggctac ctggagatca ccaagaagat gggcagcagc tccatgaagc ggagcctgag      120

aaccaacttc ctgcgctact ggaccctcac ctatctggcg ctgcccacag tgaccgacca      180

ggaggccacc cctgtgcccc ccacagggga ctccgaggcc actcccgtgc cccccacggg      240

tgactccgag accgcccccg tgccgcccac gggtgactcc ggggcccccc ccgtgccgcc      300

cacgggtgac tccggggccc cccccgtgcc gcccacgggt gactccgggg ccccccccgt      360

gccgcccacg ggtgactccg gggccccccc cgtgccgccc acgggtgact ccggggcccc      420

ccccgtgccg cccacgggtg actccggggc cccccccgtg ccgcccacgg gtgactccgg      480

ggcccccccc gtgccgccca cgggtgacgc cgggcccccc cccgtgccgc ccacgggtga      540

ctccgggccc ccccccgtgc cgcccacggg tgactccggg gccccccccg tgacccccac      600

gggtgactcc gagaccgccc ccgtgccgcc cacgggtgac tccggggccc cccctgtgcc      660

ccccacgggt gactctgagg ctgcccctgt gccccccaca gatgactcca aggaagctca      720

gatgcctgca gtcattaggt tttagcgtcc catgagcctt ggtatcaaga ggc             773


<210>  14
<211>  774
<212>  DNA
<213>  human

<400>  14
ggaccccaac atgggcgact cggctgtgcc cacacactgg gaaccctaca ctacggaaaa       60

cagcggctac ctggagatca ccaagaagat gggcagcagc tccatgaagc ggagcctgag      120

aaccaacttc ctgcgctact ggaccctcac ctatctggcg ctgcccacag tgaccgacca      180

ggaggccacc cctgtgcccc ccacagggga ctccgaggcc actcccgtgc cccccacggg      240

tgactccgag accgcccccg tgccgcccac gggtgactcc ggggcccccc ccgtgccgcc      300

cacgggtgac tccggggccc cccccgtgcc gcccacgggt gactccgggg ccccccccgt      360

gccgcccacg ggtgactccg gggccccccc ccgtgccgcc cacgggtgac tccggggccc      420

cccccgtgcc gcccacgggt gactccgggg ccccccccgt gccgcccacg ggtgactccg      480

gggccccccc cgtgccgccc acgggtgacg ccgggccccc ccccgtgccg cccacgggtg      540

actccgggcc cccccccgtg ccgcccacgg gtgactccgg ggcccccccc gtgaccccca      600

cgggtgactc cgagaccgcc cccgtgccgc ccacgggtga ctccggggcc ccccctgtgc      660

cccccacggg tgactctgag gctgcccctg tgccccccac agatgactcc aaggaagctc      720

agatgcctgc agtcattagg ttttagcgtc ccatgagcct tggtatcaag aggc            774


<210>  15
<211>  284
<212>  DNA
<213>  human

<400>  15
ggaccccaac atgggcgact cggctgtgcc cacacactgg gaaccctaca ctacggaaaa       60

cagcggctac ctggagatca ccaagaagat gggcagcagc tccatgaagc ggagcctgag      120

aaccaacttc ctgcgctact ggaccctcac ctatctggcg ctgcccacag tgaccgacca      180

ggaggccacc cctgtgcccc ccacagggga ctccgaggcc actcccgtgc cccccacggg      240

tgactccgag accgcccccg tgccgcccac gggtgactcc gggg                       284


