                         SEQUENCE LISTING

<110>  Bradley, Philip
       Stoddard, Barry L.
 
<120>  Circular Tandem Repeat Proteins

<130>  F053-0031PCT

<150>  US 62/262,146
<151>  2015-12-02

<160>  175   

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  1

Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser 
1               5                   10                  


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  2

Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
1               5                   10      


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  3

Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  4

Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  5

Glu Thr Glu Ala Lys Glu Glu Ala Glu Lys Ala Leu Lys Glu 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  6

Ser Thr Glu Ala Lys Glu Glu Ala Ile Lys Ala Leu Lys Glu 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  7

Glu Leu Glu Ala Lys Val Leu Ala Glu Lys Ala Leu Lys Glu 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  8

Glu Thr Glu Ala Lys Leu Glu Ala Glu Lys Ala Leu Lys Glu 
1               5                   10                  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  9

Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10              


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  10

Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser Lys 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  11

Lys Glu Glu Val Lys Arg Lys Phe Leu Lys Glu Leu Ser Lys 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  12

Lys Ala Glu Val Lys Arg Glu Phe Leu Trp Glu Leu Ser Leu 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  13

Lys Glu Glu Val Lys Glu Lys Phe Leu Ala Glu Leu Glu Lys 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  14

Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg Lys 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  15

Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser Phe 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  16

Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser Leu 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  17

Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser Leu 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  18

Lys Ala Glu Val Lys Leu Lys Phe Leu Phe Glu Leu Ser Phe 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  19

Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Phe Lys 
1               5                   10                  


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  20

Thr Thr Glu Ala Leu Leu Ile Leu Ile Ala Glu Ala Ser 
1               5                   10              


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  21

Val Glu Gln Gln Lys Gln Arg Phe Lys Glu Leu Val Lys Lys 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  22

Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala Lys 
1               5                   10                  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  23

Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Lys Val 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  24

Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Val Lys Val 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  25

Thr Glu Leu Glu Gln Ala Leu Arg Tyr Ala Lys Phe Val 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  26

Leu Glu Leu Thr Arg Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  27

Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Leu Val 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  28

Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Tyr Val 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  29

Pro Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  30

Thr Glu Leu Glu Arg Ala Leu Ile Phe Ala Glu Ala Val 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  31

Thr Glu Leu Asp Arg Ala Leu Trp Tyr Ala Lys Lys Val 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  32

Thr Glu Leu Glu Arg Ala Leu Leu Tyr Ala Lys Lys Val 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  33

Thr Glu Leu Glu Arg Ala Leu Ala Tyr Ala Arg Leu Val 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  34

Thr Glu Leu Glu Arg Ala Leu Ala Tyr Ala Arg Leu Val 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  35

Thr Glu Leu Glu Arg Ala Leu Trp Tyr Ala Lys Lys Val 
1               5                   10              


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  36

Ser Ala Ile Ala Thr Ala Tyr Ile Ala Leu Ala Glu Tyr Leu 
1               5                   10                  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  37

Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala Ile Lys Leu 
1               5                   10              


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  38

Ser Ala Ile Ala Glu Ala Tyr Ile Ala Leu Ala Arg Tyr Leu 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  39

Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr Ala Ser Ala Tyr 
1               5                   10                  


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  40

Thr Leu Phe Leu Arg Ala Leu Lys Leu Ala Lys Glu Val 
1               5                   10              


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  41

Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala Glu Ala Glu 
1               5                   10                  


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  42

Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys Lys 
1               5                   10              


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  43

Lys Leu Tyr Ile Glu Val Leu Ala Ile Val Ala Glu Ala Glu 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  44

Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala Lys Ala Glu 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  45

Lys Leu Tyr Ile Glu Val Leu Ala Ile Val Ala Lys Ala Glu 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  46

Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu Leu 
1               5                   10                  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  47

Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr Lys Leu 
1               5                   10                  15  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  48

Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu Leu 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  49

Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Lys Leu 
1               5                   10                  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helix generating peptide

<400>  50

Val Glu Glu Ala Val Lys Arg Ala Met Lys Leu Lys Thr Lys Leu 
1               5                   10                  15  


<210>  51
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_9x31L_sub repeat_num= 3 repeat_len= 31 protein_len= 93

<400>  51

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
        35                  40                  45              


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
    50                  55                  60                  


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
65                  70                  75                  80  


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
                85                  90              


<210>  52
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_1 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  52

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Glu Thr Glu Ala Lys Glu Glu Ala Glu Lys Ala Leu Lys 
            20                  25                  30          


Glu Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala 
        35                  40                  45              


Lys Gly Ile Thr Glu Thr Glu Ala Lys Glu Glu Ala Glu Lys Ala Leu 
    50                  55                  60                  


Lys Glu Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Lys Gly Ile Thr Glu Thr Glu Ala Lys Glu Glu Ala Glu Lys Ala 
                85                  90                  95      


Leu Lys Glu 
            


<210>  53
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_1-1 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  53

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Glu Ala Lys Glu Glu Ala Ile Lys Ala Leu Lys 
            20                  25                  30          


Glu Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala 
        35                  40                  45              


Lys Gly Ile Thr Glu Leu Glu Ala Lys Val Leu Ala Glu Lys Ala Leu 
    50                  55                  60                  


Lys Glu Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Lys Gly Ile Thr Glu Thr Glu Ala Lys Leu Glu Ala Glu Lys Ala 
                85                  90                  95      


Leu Lys Glu 
            


<210>  54
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_2 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  54

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu 
    50                  55                  60                  


Ser Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu 
                85                  90                  95      


Leu Ser Lys 
            


<210>  55
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_2-1 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  55

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Arg Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Lys Ala Glu Val Lys Arg Glu Phe Leu Trp Glu Leu 
    50                  55                  60                  


Ser Leu Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Ala Glu 
                85                  90                  95      


Leu Glu Lys 
            


<210>  56
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_2-2 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  56

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg 
            20                  25                  30          


Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu 
    50                  55                  60                  


Ser Phe Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu 
                85                  90                  95      


Leu Ser Leu 
            


<210>  57
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_2-3 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  57

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu 
    50                  55                  60                  


Ser Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Lys Arg Glu Val Lys Arg Trp Phe Leu Phe Glu 
                85                  90                  95      


Leu Arg Lys 
            


<210>  58
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_2-4 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  58

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Ala Glu Val Lys Leu Lys Phe Leu Phe Glu Leu Ser 
            20                  25                  30          


Phe Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu 
    50                  55                  60                  


Phe Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu 
                85                  90                  95      


Leu Ser Lys 
            


<210>  59
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_3x33L_3 repeat_num= 3 repeat_len= 33 protein_len= 99

<400>  59

Gly Tyr Ser Thr Thr Glu Ala Leu Leu Ile Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Val Glu Gln Gln Lys Gln Arg Phe Lys Glu Leu Val Lys 
            20                  25                  30          


Lys Gly Tyr Ser Thr Thr Glu Ala Leu Leu Ile Leu Ile Ala Glu Ala 
        35                  40                  45              


Ser Gly Thr Thr Val Glu Gln Gln Lys Gln Arg Phe Lys Glu Leu Val 
    50                  55                  60                  


Lys Lys Gly Tyr Ser Thr Thr Glu Ala Leu Leu Ile Leu Ile Ala Glu 
65                  70                  75                  80  


Ala Ser Gly Thr Thr Val Glu Gln Gln Lys Gln Arg Phe Lys Glu Leu 
                85                  90                  95      


Val Lys Lys 
            


<210>  60
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_1 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  60

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Lys 
            20                  25                  30          


Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser 
        35                  40                  45              


Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys 
    50                  55                  60                  


Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala 
65                  70                  75                  80  


Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala 
                85                  90                  95      


Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys 
            100                 105                 110         


Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr 
        115                 120                 125             


Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile 
    130                 135                 140                 


Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg 
145                 150                 155                 160 


Tyr Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala 
                165                 170                 175     


Ile Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu 
            180                 185                 190         


Arg Tyr Ala Lys Lys Val 
        195             


<210>  61
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_1-1 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  61

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Val Lys 
            20                  25                  30          


Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser 
        35                  40                  45              


Ala Lys Gly Asp Glu Thr Glu Leu Glu Gln Ala Leu Arg Tyr Ala Lys 
    50                  55                  60                  


Phe Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala 
65                  70                  75                  80  


Ser Ala Lys Gly Asp Glu Leu Glu Leu Thr Arg Ala Leu Ala Tyr Ala 
                85                  90                  95      


Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys 
            100                 105                 110         


Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr 
        115                 120                 125             


Ala Lys Leu Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile 
    130                 135                 140                 


Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg 
145                 150                 155                 160 


Tyr Ala Lys Tyr Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala 
                165                 170                 175     


Ile Lys Ala Ser Ala Lys Gly Asp Glu Pro Glu Leu Glu Tyr Ala Leu 
            180                 185                 190         


Ala Tyr Ala Lys Lys Val 
        195             


<210>  62
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_1-2 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  62

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Lys 
            20                  25                  30          


Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser 
        35                  40                  45              


Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Ile Phe Ala Glu 
    50                  55                  60                  


Ala Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala 
65                  70                  75                  80  


Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala 
                85                  90                  95      


Lys Lys Val Asn Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys 
            100                 105                 110         


Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Asp Arg Ala Leu Trp Tyr 
        115                 120                 125             


Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile 
    130                 135                 140                 


Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg 
145                 150                 155                 160 


Tyr Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala 
                165                 170                 175     


Ile Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu 
            180                 185                 190         


Leu Tyr Ala Lys Lys Val 
        195             


<210>  63
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_1-3 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  63

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Lys 
            20                  25                  30          


Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser 
        35                  40                  45              


Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Ala Tyr Ala Arg 
    50                  55                  60                  


Leu Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala 
65                  70                  75                  80  


Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala 
                85                  90                  95      


Glu Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys 
            100                 105                 110         


Ala Ser Ala Lys Gly Asp Glu Gln Glu Leu Glu Ala Ala Leu Ile Tyr 
        115                 120                 125             


Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile 
    130                 135                 140                 


Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg 
145                 150                 155                 160 


Tyr Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala 
                165                 170                 175     


Ile Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu 
            180                 185                 190         


Trp Tyr Ala Lys Lys Val 
        195             


<210>  64
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_2 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  64

Gly Asp Arg Ser Ala Ile Ala Thr Ala Tyr Ile Ala Leu Ala Glu Tyr 
1               5                   10                  15      


Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala Ile Lys 
            20                  25                  30          


Leu Gly Asp Arg Ser Ala Ile Ala Glu Ala Tyr Ile Ala Leu Ala Arg 
        35                  40                  45              


Tyr Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala Ile 
    50                  55                  60                  


Lys Leu Gly Asp Arg Ser Ala Ile Ala Thr Ala Tyr Ile Ala Leu Ala 
65                  70                  75                  80  


Glu Tyr Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala 
                85                  90                  95      


Ile Lys Leu Gly Asp Arg Ser Ala Ile Ala Glu Ala Tyr Ile Ala Leu 
            100                 105                 110         


Ala Arg Tyr Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile 
        115                 120                 125             


Ala Ile Lys Leu Gly Asp Arg Ser Ala Ile Ala Thr Ala Tyr Ile Ala 
    130                 135                 140                 


Leu Ala Glu Tyr Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu 
145                 150                 155                 160 


Ile Ala Ile Lys Leu Gly Asp Arg Ser Ala Ile Ala Glu Ala Tyr Ile 
                165                 170                 175     


Ala Leu Ala Arg Tyr Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile 
            180                 185                 190         


Glu Ile Ala Ile Lys Leu 
        195             


<210>  65
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_3 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  65

Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr Ala Ser Ala 
1               5                   10                  15      


Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys Leu Ala Lys Glu 
            20                  25                  30          


Val Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr Ala Ser 
        35                  40                  45              


Ala Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys Leu Ala Lys 
    50                  55                  60                  


Glu Val Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr Ala 
65                  70                  75                  80  


Ser Ala Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys Leu Ala 
                85                  90                  95      


Lys Glu Val Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr 
            100                 105                 110         


Ala Ser Ala Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys Leu 
        115                 120                 125             


Ala Lys Glu Val Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile 
    130                 135                 140                 


Tyr Ala Ser Ala Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Lys Glu Val Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala 
                165                 170                 175     


Ile Tyr Ala Ser Ala Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu 
            180                 185                 190         


Lys Leu Ala Lys Glu Val 
        195             


<210>  66
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x33R_4 repeat_num= 6 repeat_len= 33 protein_len= 198

<400>  66

Gly Asp Leu Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala Glu Ala 
1               5                   10                  15      


Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys 
            20                  25                  30          


Lys Gly Asp Leu Lys Leu Tyr Ile Glu Val Leu Ala Ile Val Ala Glu 
        35                  40                  45              


Ala Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu 
    50                  55                  60                  


Lys Lys Gly Asp Leu Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala 
65                  70                  75                  80  


Lys Ala Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala 
                85                  90                  95      


Leu Lys Lys Gly Asp Leu Lys Leu Tyr Ile Glu Val Leu Ala Ile Val 
            100                 105                 110         


Ala Glu Ala Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu 
        115                 120                 125             


Ala Leu Lys Lys Gly Asp Leu Glu Leu Tyr Ile Arg Val Leu Ala Ile 
    130                 135                 140                 


Val Ala Glu Ala Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Leu Lys Lys Gly Asp Leu Lys Leu Tyr Ile Glu Val Leu Ala 
                165                 170                 175     


Ile Val Ala Lys Ala Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu 
            180                 185                 190         


Lys Leu Ala Leu Lys Lys 
        195             


<210>  67
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x35L repeat_num= 6 repeat_len= 35 protein_len= 210

<400>  67

Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu Leu 
1               5                   10                  15      


Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr 
            20                  25                  30          


Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala 
        35                  40                  45              


Ala Glu Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys 
    50                  55                  60                  


Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu 
65                  70                  75                  80  


Glu Val Ala Ala Lys Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg 
                85                  90                  95      


Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu 
            100                 105                 110         


Lys Ile Leu Lys Val Ala Ala Glu Leu Gly Thr Thr Val Glu Glu Ala 
        115                 120                 125             


Val Lys Arg Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu 
    130                 135                 140                 


Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu Leu Gly Thr Thr Val 
145                 150                 155                 160 


Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr Lys Leu Gly Val 
                165                 170                 175     


Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Lys Leu Gly 
            180                 185                 190         


Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr Lys 
        195                 200                 205             


Leu Gly 
    210 


<210>  68
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_6x35L(SeMet) repeat_num= 6 repeat_len= 35 protein_len= 210

<400>  68

Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu Leu 
1               5                   10                  15      


Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr 
            20                  25                  30          


Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala 
        35                  40                  45              


Ala Glu Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys 
    50                  55                  60                  


Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu 
65                  70                  75                  80  


Glu Val Ala Ala Lys Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg 
                85                  90                  95      


Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu 
            100                 105                 110         


Lys Ile Leu Lys Val Ala Ala Glu Leu Gly Thr Thr Val Glu Glu Ala 
        115                 120                 125             


Val Lys Arg Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu 
    130                 135                 140                 


Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu Leu Gly Thr Thr Val 
145                 150                 155                 160 


Glu Glu Ala Val Lys Arg Ala Met Lys Leu Lys Thr Lys Leu Gly Val 
                165                 170                 175     


Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Lys Leu Gly 
            180                 185                 190         


Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr Lys 
        195                 200                 205             


Leu Gly 
    210 


<210>  69
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_9x31L repeat_num= 9 repeat_len= 31 protein_len= 279

<400>  69

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
        35                  40                  45              


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
    50                  55                  60                  


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
65                  70                  75                  80  


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
                85                  90                  95      


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr 
            100                 105                 110         


Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val 
        115                 120                 125             


Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr 
    130                 135                 140                 


Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu 
145                 150                 155                 160 


Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val 
                165                 170                 175     


Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu 
            180                 185                 190         


Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu 
        195                 200                 205             


Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu 
    210                 215                 220                 


Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu 
225                 230                 235                 240 


Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu 
                245                 250                 255     


Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala 
            260                 265                 270         


Tyr Lys Leu Ala Leu Lys Leu 
        275                 


<210>  70
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTor_12x31L repeat_num= 12 repeat_len= 31 protein_len= 372

<400>  70

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
        35                  40                  45              


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
    50                  55                  60                  


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
65                  70                  75                  80  


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
                85                  90                  95      


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr 
            100                 105                 110         


Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val 
        115                 120                 125             


Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr 
    130                 135                 140                 


Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu 
145                 150                 155                 160 


Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val 
                165                 170                 175     


Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu 
            180                 185                 190         


Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu 
        195                 200                 205             


Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu 
    210                 215                 220                 


Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu 
225                 230                 235                 240 


Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu 
                245                 250                 255     


Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala 
            260                 265                 270         


Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys 
        275                 280                 285             


Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr 
    290                 295                 300                 


Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
305                 310                 315                 320 


Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
                325                 330                 335     


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
            340                 345                 350         


Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
        355                 360                 365             


Ala Leu Lys Leu 
    370         


<210>  71
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_12x_insert_single

<400>  71

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
        35                  40                  45              


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
    50                  55                  60                  


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
65                  70                  75                  80  


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
                85                  90                  95      


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr 
            100                 105                 110         


Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val 
        115                 120                 125             


Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr 
    130                 135                 140                 


Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu 
145                 150                 155                 160 


Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Ser Gly Gly 
                165                 170                 175     


Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala 
            180                 185                 190         


Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu 
        195                 200                 205             


Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn 
    210                 215                 220                 


Lys His Phe Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln 
225                 230                 235                 240 


Arg Arg Phe His Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala 
                245                 250                 255     


Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala 
            260                 265                 270         


Leu Gln Gly Ser Gly Gly Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
        275                 280                 285             


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
    290                 295                 300                 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
305                 310                 315                 320 


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr 
                325                 330                 335     


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            340                 345                 350         


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
        355                 360                 365             


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
    370                 375                 380                 


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser 
385                 390                 395                 400 


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
                405                 410                 415     


Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly 
            420                 425                 430         


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
        435                 440                 445             


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr 
    450                 455                 460                 


Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
465                 470                 475         


<210>  72
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_12x_insert_double

<400>  72

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
        35                  40                  45              


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
    50                  55                  60                  


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
65                  70                  75                  80  


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
                85                  90                  95      


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Ser 
            100                 105                 110         


Gly Gly Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu 
        115                 120                 125             


Cys Ala Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp 
    130                 135                 140                 


Ser Glu Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly 
145                 150                 155                 160 


Lys Asn Lys His Phe Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe His Thr Met Asp Glu Leu Val Glu His Tyr Lys 
            180                 185                 190         


Lys Ala Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val 
        195                 200                 205             


Arg Ala Leu Gln Gly Ser Gly Gly Thr Val Glu Glu Ala Tyr Lys Leu 
    210                 215                 220                 


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu 
225                 230                 235                 240 


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
                245                 250                 255     


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala 
            260                 265                 270         


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
        275                 280                 285             


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
    290                 295                 300                 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
305                 310                 315                 320 


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr 
                325                 330                 335     


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            340                 345                 350         


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
        355                 360                 365             


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
    370                 375                 380                 


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His Gln 
                405                 410                 415     


Ala Glu Cys Ala Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu Ile 
            420                 425                 430         


Arg Asp Ser Glu Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys Ala 
        435                 440                 445             


Ser Gly Lys Asn Lys His Phe Lys Val Gln Leu Val Asp Asn Val Tyr 
    450                 455                 460                 


Cys Ile Gly Gln Arg Arg Phe His Thr Met Asp Glu Leu Val Glu His 
465                 470                 475                 480 


Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu Tyr 
                485                 490                 495     


Leu Val Arg Ala Leu Gln Gly Ser Gly Gly Thr Val Glu Glu Ala Tyr 
            500                 505                 510         


Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
        515                 520                 525             


Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
    530                 535                 540                 


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
545                 550                 555                 560 


Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
                565                 570                 575     


Ala Leu Lys Leu Gly 
            580     


<210>  73
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  73

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            20                  25                  30      


<210>  74
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  74

Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr 
1               5                   10                  15      


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            20                  25                  30      


<210>  75
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  75

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Glu Thr Glu Ala Lys Glu Glu Ala Glu Lys Ala Leu Lys 
            20                  25                  30          


Glu 
    


<210>  76
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  76

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Glu Ala Lys Glu Glu Ala Ile Lys Ala Leu Lys 
            20                  25                  30          


Glu 
    


<210>  77
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  77

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Glu Leu Glu Ala Lys Val Leu Ala Glu Lys Ala Leu Lys 
            20                  25                  30          


Glu 
    


<210>  78
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  78

Gly Lys Ser Pro Thr Glu Ala Leu Leu Lys Leu Ile Ala Glu Ala Lys 
1               5                   10                  15      


Gly Ile Thr Glu Thr Glu Ala Lys Leu Glu Ala Glu Lys Ala Leu Lys 
            20                  25                  30          


Glu 
    


<210>  79
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  79

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Lys 
    


<210>  80
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  80

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Arg Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Lys 
    


<210>  81
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  81

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Ala Glu Val Lys Arg Glu Phe Leu Trp Glu Leu Ser 
            20                  25                  30          


Leu 
    


<210>  82
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  82

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Ala Glu Leu Glu 
            20                  25                  30          


Lys 
    


<210>  83
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  83

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg 
            20                  25                  30          


Lys 
    


<210>  84
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  84

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Phe 
    


<210>  85
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  85

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser 
            20                  25                  30          


Leu 
    


<210>  86
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  86

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Arg Glu Val Lys Arg Trp Phe Leu Phe Glu Leu Arg 
            20                  25                  30          


Lys 
    


<210>  87
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  87

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Ala Glu Val Lys Leu Lys Phe Leu Phe Glu Leu Ser 
            20                  25                  30          


Phe 
    


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  88

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Phe 
            20                  25                  30          


Lys 
    


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  89

Gly Tyr Ser Thr Thr Glu Ala Leu Leu Ile Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Val Glu Gln Gln Lys Gln Arg Phe Lys Glu Leu Val Lys 
            20                  25                  30          


Lys 
    


<210>  90
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  90

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  91

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Val Lys 
            20                  25                  30          


Val 
    


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  92

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Gln Ala Leu Arg Tyr Ala Lys Phe 
            20                  25                  30          


Val 
    


<210>  93
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  93

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Leu Glu Leu Thr Arg Ala Leu Ala Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  94
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  94

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Leu 
            20                  25                  30          


Val 
    


<210>  95
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  95

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Lys Tyr 
            20                  25                  30          


Val 
    


<210>  96
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  96

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Pro Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  97
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  97

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Ile Phe Ala Glu Ala 
            20                  25                  30          


Val 
    


<210>  98
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  98

Asn Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Asp Arg Ala Leu Trp Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  99
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  99

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Leu Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  100
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  100

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Ala Tyr Ala Arg Leu 
            20                  25                  30          


Val 
    


<210>  101
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  101

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Glu Lys 
            20                  25                  30          


Val 
    


<210>  102
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  102

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Gln Glu Leu Glu Ala Ala Leu Ile Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  103
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  103

Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser Ala 
1               5                   10                  15      


Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Trp Tyr Ala Lys Lys 
            20                  25                  30          


Val 
    


<210>  104
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  104

Gly Asp Arg Ser Ala Ile Ala Thr Ala Tyr Ile Ala Leu Ala Glu Tyr 
1               5                   10                  15      


Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala Ile Lys 
            20                  25                  30          


Leu 
    


<210>  105
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  105

Gly Asp Arg Ser Ala Ile Ala Glu Ala Tyr Ile Ala Leu Ala Arg Tyr 
1               5                   10                  15      


Leu Gly Asp Lys Glu Ala Leu Leu Lys Ala Ile Glu Ile Ala Ile Lys 
            20                  25                  30          


Leu 
    


<210>  106
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  106

Gly Asp Lys Ser Ala Leu Ala Gln Ile Leu Ala Ile Tyr Ala Ser Ala 
1               5                   10                  15      


Tyr Gly Asp Thr Thr Leu Phe Leu Arg Ala Leu Lys Leu Ala Lys Glu 
            20                  25                  30          


Val 
    


<210>  107
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  107

Gly Asp Leu Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala Glu Ala 
1               5                   10                  15      


Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys 
            20                  25                  30          


Lys 
    


<210>  108
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  108

Gly Asp Leu Lys Leu Tyr Ile Glu Val Leu Ala Ile Val Ala Glu Ala 
1               5                   10                  15      


Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys 
            20                  25                  30          


Lys 
    


<210>  109
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  109

Gly Asp Leu Glu Leu Tyr Ile Arg Val Leu Ala Ile Val Ala Lys Ala 
1               5                   10                  15      


Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys 
            20                  25                  30          


Lys 
    


<210>  110
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  110

Gly Asp Leu Lys Leu Tyr Ile Glu Val Leu Ala Ile Val Ala Lys Ala 
1               5                   10                  15      


Glu Gly Asp Lys Thr Lys Leu Glu Leu Ala Leu Lys Leu Ala Leu Lys 
            20                  25                  30          


Lys 
    


<210>  111
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  111

Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu 
        35  


<210>  112
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  112

Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu 
        35  


<210>  113
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  113

Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Lys 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu 
        35  


<210>  114
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical structure joined by linkers

<400>  114

Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Met Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu 
        35  


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide adjuvant from HMGB1

<400>  115

Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys 
1               5                   10                  15      


Ser Glu 
        


<210>  116
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide from in-frame deletion in EGFR

<400>  116

Leu Glu Glu Lys Lys Gly Asn Tyr Trp Thr Asp His Cys 
1               5                   10              


<210>  117
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  117

Met Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala 
1               5                   10                  15      


Ser Gly Thr Thr Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu 
            20                  25                  30          


Arg Lys Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu 
        35                  40                  45              


Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu 
    50                  55                  60                  


Leu Ser Phe Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala 
65                  70                  75                  80  


Glu Ala Ser Gly Thr Thr Lys Glu Glu Val Lys Lys Lys Phe Trp Lys 
                85                  90                  95      


Glu Leu Ser Leu 
            100 


<210>  118
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  118

Met Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala Ser 
1               5                   10                  15      


Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg Tyr Ala Val 
            20                  25                  30          


Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys Ala 
        35                  40                  45              


Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Gln Ala Leu Arg Tyr Ala 
    50                  55                  60                  


Lys Phe Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile Lys 
65                  70                  75                  80  


Ala Ser Ala Lys Gly Asp Glu Leu Glu Leu Thr Arg Ala Leu Ala Tyr 
                85                  90                  95      


Ala Lys Lys Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala Ile 
            100                 105                 110         


Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu Arg 
        115                 120                 125             


Tyr Ala Lys Leu Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu Ala 
    130                 135                 140                 


Ile Lys Ala Ser Ala Lys Gly Asp Glu Thr Glu Leu Glu Arg Ala Leu 
145                 150                 155                 160 


Arg Tyr Ala Lys Tyr Val Gly Asp Lys Thr Ala Ile Ala Gln Ile Leu 
                165                 170                 175     


Ala Ile Lys Ala Ser Ala Lys Gly Asp Glu Pro Glu Leu Glu Tyr Ala 
            180                 185                 190         


Leu Ala Tyr Ala Lys Lys Val 
        195                 


<210>  119
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  119

Leu Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val 
        35                  40                  45              


Ala Ala Glu Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu 
    50                  55                  60                  


Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala Leu Lys Ile 
65                  70                  75                  80  


Leu Glu Val Ala Ala Lys Leu Gly Thr Thr Val Glu Glu Ala Val Lys 
                85                  90                  95      


Arg Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu Glu Gln Ala 
            100                 105                 110         


Leu Lys Ile Leu Lys Val Ala Ala Glu Leu Gly Thr Thr Val Glu Glu 
        115                 120                 125             


Ala Val Lys Arg Ala Leu Lys Leu Lys Thr Lys Leu Gly Val Ser Leu 
    130                 135                 140                 


Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Glu Leu Gly Thr Thr 
145                 150                 155                 160 


Val Glu Glu Ala Val Lys Arg Ala Met Lys Leu Lys Thr Lys Leu Gly 
                165                 170                 175     


Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Glu Val Ala Ala Lys Leu 
            180                 185                 190         


Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys Thr 
        195                 200                 205             


Lys Leu Gly Gly Trp Leu Glu His His His His His His 
    210                 215                 220     


<210>  120
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  120

Gly Ser Ser Met Ala Ser Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
1               5                   10                  15      


Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
            20                  25                  30          


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
        35                  40                  45              


Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
    50                  55                  60                  


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
65                  70                  75                  80  


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
                85                  90                  95      


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala 
            100                 105                 110         


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
        115                 120                 125             


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala 
    130                 135                 140                 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
145                 150                 155                 160 


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr 
                165                 170                 175     


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            180                 185                 190         


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
        195                 200                 205             


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
    210                 215                 220                 


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
225                 230                 235                 240 


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
                245                 250                 255     


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
            260                 265                 270         


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
        275                 280                 285     


<210>  121
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  121

Gly Ser Ser Met Ala Ser Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
1               5                   10                  15      


Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
            20                  25                  30          


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
        35                  40                  45              


Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
    50                  55                  60                  


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
65                  70                  75                  80  


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
                85                  90                  95      


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala 
            100                 105                 110         


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
        115                 120                 125             


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala 
    130                 135                 140                 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
145                 150                 155                 160 


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr 
                165                 170                 175     


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
            180                 185                 190         


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
        195                 200                 205             


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
    210                 215                 220                 


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser 
225                 230                 235                 240 


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile 
                245                 250                 255     


Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly 
            260                 265                 270         


Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser 
        275                 280                 285             


Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr 
    290                 295                 300                 


Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val 
305                 310                 315                 320 


Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr 
                325                 330                 335     


Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu 
            340                 345                 350         


Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val 
        355                 360                 365             


Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
    370                 375                 


<210>  122
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  122

Gly Ser Ser Met Ala Ser Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
1               5                   10                  15      


Ala Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
            20                  25                  30          


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
        35                  40                  45              


Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
    50                  55                  60                  


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
65                  70                  75                  80  


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
                85                  90                  95      


Leu Lys Leu Gly 
            100 


<210>  123
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  123

Gly Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
1               5                   10                  15      


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
            20                  25                  30          


His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu 
        35                  40                  45              


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
    50                  55                  60                  


Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
                85                  90                  95      


Ala Ala His Ala Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala 
            100                 105                 110         


Glu Leu Gly Lys Ala Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu 
        115                 120                 125             


Met Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala 
    130                 135                 140                 


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
145                 150                 155                 160 


Leu Arg Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala 
                165                 170                 175     


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            180                 185                 190         


Leu Leu Arg Ala Ala His Gly Leu Gly Leu Asn Pro Glu Ala Ile Lys 
        195                 200                 205             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    210                 215                 220                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile 
225                 230                 235                 240 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                245                 250                 255     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala 
            260                 265                 270         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        275                 280                 285             


Ile Leu Glu Leu Leu Arg Ala Ala His Ala Leu Gly Leu Asn Pro Glu 
    290                 295                 300                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Ala 
305                 310                 315                 320 


Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu Leu Gly Leu Asn Pro 
                325                 330                 335     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            340                 345                 350         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asn 
        355                 360                 365             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    370                 375                 380                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly Leu Gly Leu 
385                 390                 395                 400 


Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                405                 410                 415     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            420                 425                 430         


Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        435                 440                 445             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    450                 455                 460                 


Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala 
                485                 490                 495     


Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
            500                 505                 510         


Ala Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His 
        515                 520                 525             


Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
    530                 535                 540                 


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
545                 550                 555                 560 


His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu 
                565                 570                 575     


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
            580                 585                 590         


Ala His Gly Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu 
        595                 600                 605             


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
    610                 615                 620                 


Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala 
625                 630                 635                 640 


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
                645                 650                 655     


Arg Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala 
            660                 665                 670         


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
        675                 680                 685             


Leu Arg Ala Ala His Ala Leu Gly Leu Asn Pro Glu Ala Ile Lys Ala 
    690                 695                 700                 


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Ala Glu Ile Leu Glu 
705                 710                 715                 720 


Leu Leu Met Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile Lys 
                725                 730                 735     


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
            740                 745                 750         


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asn Pro Glu Ala Ile 
        755                 760                 765             


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
    770                 775                 780                 


Leu Glu Leu Leu Arg Ala Ala His Gly Gly Trp 
785                 790                 795 


<210>  124
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  124

Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  125

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  126

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala Leu 
1               5                   10                  


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  127

Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu Leu 
1               5                   10                  


<210>  128
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  128

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly Leu 
1               5                   10                  


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  129

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly Gly 
1               5                   10                  


<210>  130
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  130

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  131
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  131

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala 
            20                  25                  30          


Leu 
    


<210>  132
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  132

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  133
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  133

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Leu 
    


<210>  134
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  134

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Gly 
    


<210>  135
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_24x_sub8__Protein

<400>  135

Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
1               5                   10                  15      


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
            20                  25                  30          


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
        35                  40                  45              


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
    50                  55                  60                  


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
65                  70                  75                  80  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
                85                  90                  95      


Leu Arg Ala Ala His Val Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
            100                 105                 110         


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
        115                 120                 125             


Leu Leu Val Ala Ala His Leu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
    130                 135                 140                 


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
145                 150                 155                 160 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
                165                 170                 175     


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
            180                 185                 190         


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
        195                 200                 205             


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
    210                 215                 220                 


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
225                 230                 235                 240 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Ile 
                245                 250                 255     


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
            260                 265                 270     


<210>  136
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_24x_sub6_Protein

<400>  136

Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
1               5                   10                  15      


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
            20                  25                  30          


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
        35                  40                  45              


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
    50                  55                  60                  


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
65                  70                  75                  80  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
                85                  90                  95      


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
            100                 105                 110         


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
        115                 120                 125             


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
    130                 135                 140                 


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
145                 150                 155                 160 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
                165                 170                 175     


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
            180                 185                 190         


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
        195                 200             


<210>  137
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_24x_sub4_Protein

<400>  137

Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
1               5                   10                  15      


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
            20                  25                  30          


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
        35                  40                  45              


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
    50                  55                  60                  


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
65                  70                  75                  80  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
                85                  90                  95      


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
            100                 105                 110         


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
        115                 120                 125             


Leu Leu Arg Ala Ala His Glu Leu Gly 
    130                 135         


<210>  138
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  design_24x_sub3_Protein

<400>  138

Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
1               5                   10                  15      


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
            20                  25                  30          


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
        35                  40                  45              


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
    50                  55                  60                  


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
65                  70                  75                  80  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
                85                  90                  95      


Leu Arg Ala Ala His Glu Leu Gly 
            100                 


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  139

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val Leu 
1               5                   10                  


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  140

Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  141
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  141

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  142
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  142

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val 
            20                  25                  30          


Leu 
    


<210>  143
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  143

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Val Ala Ala His Leu 
            20                  25                  30          


Leu 
    


<210>  144
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  144

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  145
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  145

Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala 
1               5                   10                  15      


Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu 
            20                  25                  30          


Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu 
        35                  40                  45              


Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly Asn Leu Glu Leu Ala Leu 
    50                  55                  60                  


Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val Leu Ala Glu Ile 
65                  70                  75                  80  


Ala Arg Asp Arg Gly Asn Glu Glu Leu Leu Glu Lys Ala Ala Arg Leu 
                85                  90                  95      


Ala Glu Glu Ala Ala Arg Gln Ala Glu Glu Ile Ala Arg Gln Ala Arg 
            100                 105                 110         


Lys Glu Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val 
        115                 120                 125             


Asn Ala Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu 
    130                 135                 140                 


Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln 
145                 150                 155                 160 


Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly Asn Leu Glu Leu 
                165                 170                 175     


Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val Leu Ala 
            180                 185                 190         


Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu Leu Glu Lys Ala Ala 
        195                 200                 205             


Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu Glu Ile Ala Arg Gln 
    210                 215                 220                 


Ala Arg Lys Glu Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile 
225                 230                 235                 240 


Leu Val Asn Ala Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly 
                245                 250                 255     


Asn Glu Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala 
            260                 265                 270         


Arg Gln Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly Asn Leu 
        275                 280                 285             


Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val 
    290                 295                 300                 


Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu Leu Glu Lys 
305                 310                 315                 320 


Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu Glu Ile Ala 
                325                 330                 335     


Arg Gln Ala Arg Lys Glu Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu 
            340                 345                 350         


Gln Ile Leu Val Asn Ala Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp 
        355                 360                 365             


Arg Gly Asn Glu Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu 
    370                 375                 380                 


Ala Ala Arg Gln Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly 
385                 390                 395                 400 


Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala 
                405                 410                 415     


Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu Leu 
            420                 425                 430         


Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu Glu 
        435                 440                 445             


Ile Ala Arg Gln Ala Arg Lys Glu Gly Asn Leu Glu Leu Ala Leu Lys 
    450                 455                 460                 


Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val Leu Ala Glu Ile Ala 
465                 470                 475                 480 


Arg Asp Arg Gly Asn Glu Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala 
                485                 490                 495     


Glu Glu Ala Ala Arg Gln Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys 
            500                 505                 510         


Glu Gly 
        


<210>  146
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  146

Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val 
1               5                   10                  15      


Leu Ala Glu Ile Ala Arg Asp Arg 
            20                  


<210>  147
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures

<400>  147

Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln 
1               5                   10                  15      


Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu 
            20                  25          


<210>  148
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  repetitive sequences forming alpha helical structures joined by 
       linkers

<400>  148

Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala 
1               5                   10                  15      


Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu 
            20                  25                  30          


Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu 
        35                  40                  45              


Glu Ile Ala Arg Gln Ala Arg Lys Glu 
    50                  55          


<210>  149
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  149

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
            20                  25                  30          


Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
        35                  40                  45              


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu 
    50                  55                  60                  


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala 
                85                  90                  95      


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
            100                 105                 110         


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
        115                 120                 125             


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
    130                 135                 140                 


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr 
145                 150                 155                 160 


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
                165                 170                 175     


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr 
            180                 185                 190         


Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Ser Glu Trp Tyr 
        195                 200                 205             


Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn Glu Arg 
    210                 215                 220                 


Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Ser 
225                 230                 235                 240 


Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His Phe Lys 
                245                 250                 255     


Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg Phe His 
            260                 265                 270         


Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr 
        275                 280                 285             


Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Ser Gly Ser Gly Thr Val Glu Glu Ala Tyr Lys Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
                325                 330                 335     


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
            340                 345                 350         


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala 
        355                 360                 365             


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
    370                 375                 380                 


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
385                 390                 395                 400 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
                405                 410                 415     


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr 
            420                 425                 430         


Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu 
        435                 440                 445             


Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala Ala Tyr Tyr 
    450                 455                 460                 


Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
465                 470                 475                 480 


Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr Tyr Ser 
                485                 490                 495     


Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys Leu Gly 
            500                 505                 510     


<210>  150
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  150

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
            20                  25                  30          


Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
        35                  40                  45              


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu 
    50                  55                  60                  


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala 
                85                  90                  95      


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
            100                 105                 110         


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
        115                 120                 125             


Tyr Tyr Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Ser Glu 
    130                 135                 140                 


Trp Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn 
145                 150                 155                 160 


Glu Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser 
                165                 170                 175     


Pro Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His 
            180                 185                 190         


Phe Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg 
        195                 200                 205             


Phe His Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile 
    210                 215                 220                 


Phe Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Thr Val Glu Glu Ala Tyr 
                245                 250                 255     


Lys Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu 
            260                 265                 270         


Ala Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys 
        275                 280                 285             


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
    290                 295                 300                 


Lys Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
                325                 330                 335     


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
            340                 345                 350         


Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Glu Ala 
        355                 360                 365             


Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu 
    370                 375                 380                 


Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala 
385                 390                 395                 400 


Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala Leu Lys 
                405                 410                 415     


Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys Ala Ala Tyr 
            420                 425                 430         


Tyr Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Ser Glu Trp 
        435                 440                 445             


Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn Glu 
    450                 455                 460                 


Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro 
465                 470                 475                 480 


Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His Phe 
                485                 490                 495     


Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg Phe 
            500                 505                 510         


His Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile Phe 
        515                 520                 525             


Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Gly Ser Gly Thr Val Glu Glu Ala Tyr Lys 
545                 550                 555                 560 


Leu Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala 
                565                 570                 575     


Glu Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu 
            580                 585                 590         


Ala Leu Lys Leu Gly Ile Ser Val Glu Glu Leu Leu Lys Leu Ala Lys 
        595                 600                 605             


Ala Ala Tyr Tyr Ser Gly Thr Thr Val Glu Glu Ala Tyr Lys Leu Ala 
    610                 615                 620                 


Leu Lys Leu Gly 
625             


<210>  151
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP

<400>  151

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
    130                 135                 140                 


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
145                 150                 155                 160 


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
                165                 170                 175     


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
            180                 185                 190         


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
        195                 200                 205             


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
    210                 215                 220                 


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
225                 230                 235                 240 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
                245                 250                 255     


Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Ser 
            260                 265                 270         


Gly Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
        275                 280                 285             


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
    290                 295                 300                 


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
305                 310                 315                 320 


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
                325                 330                 335     


His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu 
            340                 345                 350         


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
        355                 360                 365             


Ala His Glu Leu Gly 
    370             


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  152

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  153

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  154
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  functional domain

<400>  154

Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala 
1               5                   10                  15      


Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu 
            20                  25                  30          


Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn 
        35                  40                  45              


Lys His Phe Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln 
    50                  55                  60                  


Arg Arg Phe His Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala 
65                  70                  75                  80  


Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala 
                85                  90                  95      


Leu Gln 
        


<210>  155
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  functional domain

<400>  155

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  156
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  symmetry breaking motif

<400>  156

Lys Lys Lys Lys Lys Lys 
1               5       


<210>  157
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  symmetry breaking motif

<400>  157

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  symmetry breaking motif

<400>  158

Lys Glu Lys Glu Lys Glu 
1               5       


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide recognized by SH2 domain

<400>  159

Glu His Ile Tyr Asp Glu Val Ala Ala Asp 
1               5                   10  


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  160

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  161

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  162

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  163
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  163

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  164
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  164

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  165
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  165

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro 
            20                  25                  30          


Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys 
        35                  40                  45              


Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic CMV peptide

<400>  166

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  167
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scMHC cTRP construct

<400>  167

Asn Leu Val Pro Met Val Ala Thr Val Gly Cys Gly Ala Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg 
        195                 200                 205             


Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg 
225                 230                 235                 240 


Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys His 
        275                 280                 285             


Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala 
                325                 330                 335     


Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Glu Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Glu Ala 
            420                 425                 430         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        435                 440                 445             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    450                 455                 460                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
465                 470                 475                 480 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                485                 490                 495     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            500                 505                 510         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        515                 520                 525             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    530                 535                 540                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
545                 550                 555                 560 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                565                 570                 575     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            580                 585                 590         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        595                 600                 605             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    610                 615                 620                 


Gly Leu Asp Glu Asn Leu Tyr Phe Gln Gly Ser His His His His His 
625                 630                 635                 640 


His 
    


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  168

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  169
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  169

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  170
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  toroid repeat

<400>  170

Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
1               5                   10                  15      


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
            20                  25                  30          


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
        35                  40                  45              


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
    50                  55                  60                  


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
65                  70                  75                  80  


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
                85                  90                  95      


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
            100                 105                 110         


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
        115                 120                 125             


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
    130                 135                 140                 


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
145                 150                 155                 160 


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
                165                 170                 175     


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
            180                 185                 190         


His Glu Leu Gly Leu Asp 
        195             


<210>  171
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV cleavage site and His tag

<400>  171

Glu Asn Leu Tyr Phe Gln Gly Ser His His His His His His 
1               5                   10                  


<210>  172
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha helical repeat

<400>  172

Leu Val Ser Leu Glu Gln Ala Leu Lys Ile Leu Lys Val Ala Ala Glu 
1               5                   10                  15      


Leu Gly Thr Thr Val Glu Glu Ala Val Lys Arg Ala Leu Lys Leu Lys 
            20                  25                  30          


Thr Lys Leu 
        35  


<210>  173
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  174
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  175
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


