                         SEQUENCE LISTING

<110>  National Health Research Institutes
 
<120>  HETERODIMERIC VASCULAR ENDOTHELIAL GROWTH FACTOR AND USE THEREOF

<130>  218384-0006PCT

<150>  US 62/262,630
<151>  2015-12-03

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  444
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(444)
<223>  VEGF121

<400>  1
atg aac ttt ctg ctg tct tgg gtg cat tgg agc ctt gcc ttg ctg ctc         48
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu           
1               5                   10                  15                

tac ctc cac cat gcc aag tgg tcc cag gct gca ccc atg gca gaa gga         96
Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly           
            20                  25                  30                    

gga ggg cag aat cat cac gaa gtg gtg aag ttc atg gat gtc tat cag        144
Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln           
        35                  40                  45                        

cgc agc tac tgc cat cca atc gag acc ctg gtg gac atc ttc cag gag        192
Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu           
    50                  55                  60                            

tac cct gat gag atc gag tac atc ttc aag cca tcc tgt gtg ccc ctg        240
Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu           
65                  70                  75                  80            

atg cga tgc ggg ggc tgc tgc aat gac gag ggc ctg gag tgt gtg ccc        288
Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro           
                85                  90                  95                

act gag gag tcc aac atc acc atg cag att atg cgg atc aaa cct cac        336
Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His           
            100                 105                 110                   

caa ggc cag cac ata gga gag atg agc ttc cta cag cac aac aaa tgt        384
Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys           
        115                 120                 125                       

gaa tgc aga cca aag aaa gat aga gca aga caa gaa aaa tgt gac aag        432
Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys           
    130                 135                 140                           

ccg agg cgg tga                                                        444
Pro Arg Arg                                                               
145                                                                       


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  3
<211>  576
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(576)
<223>  VEGF165

<400>  3
atg aac ttt ctg ctg tct tgg gtg cat tgg agc ctt gcc ttg ctg ctc         48
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu           
1               5                   10                  15                

tac ctc cac cat gcc aag tgg tcc cag gct gca ccc atg gca gaa gga         96
Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly           
            20                  25                  30                    

gga ggg cag aat cat cac gaa gtg gtg aag ttc atg gat gtc tat cag        144
Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln           
        35                  40                  45                        

cgc agc tac tgc cat cca atc gag acc ctg gtg gac atc ttc cag gag        192
Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu           
    50                  55                  60                            

tac cct gat gag atc gag tac atc ttc aag cca tcc tgt gtg ccc ctg        240
Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu           
65                  70                  75                  80            

atg cga tgc ggg ggc tgc tgc aat gac gag ggc ctg gag tgt gtg ccc        288
Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro           
                85                  90                  95                

act gag gag tcc aac atc acc atg cag att atg cgg atc aaa cct cac        336
Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His           
            100                 105                 110                   

caa ggc cag cac ata gga gag atg agc ttc cta cag cac aac aaa tgt        384
Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys           
        115                 120                 125                       

gaa tgc aga cca aag aaa gat aga gca aga caa gaa aat ccc tgt ggg        432
Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly           
    130                 135                 140                           

cct tgc tca gag cgg aga aag cat ttg ttt gta caa gat ccg cag acg        480
Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr           
145                 150                 155                 160           

tgt aaa tgt tcc tgc aaa aac aca gac tcg cgt tgc aag gcg agg cag        528
Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln           
                165                 170                 175               

ctt gag tta aac gaa cgt act tgc aga tgt gac aag ccg agg cgg tga        576
Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg               
            180                 185                 190                   


<210>  4
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  5
<211>  711
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(711)
<223>  Fc

<400>  5
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgg gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac        576
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa gtc gac gag ggc ccg                    711
Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Glu Gly Pro                       
225                 230                 235                               


<210>  6
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Glu Gly Pro 
225                 230                 235         


<210>  7
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic linker

<400>  7

Gly Gly Gly Gly Ser 
1               5   


<210>  8
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(78)
<223>  Signal peptide

<400>  8
aac ttt ctg ctg tct tgg gtg cat tgg agc ctt gcc ttg ctg ctc tac         48
Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu Tyr           
1               5                   10                  15                

ctc cac cat gcc aag tgg tcc cag gct gca                                 78
Leu His His Ala Lys Trp Ser Gln Ala Ala                                   
            20                  25                                        


<210>  9
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9

Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu Tyr 
1               5                   10                  15      


Leu His His Ala Lys Trp Ser Gln Ala Ala 
            20                  25      


<210>  10
<211>  2388
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(2388)
<223>  VEGF121-Fc-linker-Fc-VEGF165-6xHis tag

<400>  10
atg aac ttt ctg ctg tct tgg gtg cat tgg agc ctt gcc ttg ctg ctc         48
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu           
1               5                   10                  15                

tac ctc cac cat gcc aag tgg tcc cag gct gca ccc atg gca gaa gga         96
Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly           
            20                  25                  30                    

gga ggg cag aat cat cac gaa gtg gtg aag ttc atg gat gtc tat cag        144
Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln           
        35                  40                  45                        

cgc agc tac tgc cat cca atc gag acc ctg gtg gac atc ttc cag gag        192
Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu           
    50                  55                  60                            

tac cct gat gag atc gag tac atc ttc aag cca tcc tgt gtg ccc ctg        240
Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu           
65                  70                  75                  80            

atg cga tgc ggg ggc tgc tgc aat gac gag ggc ctg gag tgt gtg ccc        288
Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro           
                85                  90                  95                

act gag gag tcc aac atc acc atg cag att atg cgg atc aaa cct cac        336
Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His           
            100                 105                 110                   

caa ggc cag cac ata gga gag atg agc ttc cta cag cac aac aaa tgt        384
Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys           
        115                 120                 125                       

gaa tgc aga cca aag aaa gat gag ccc aaa tct tgt gac aaa act cac        432
Glu Cys Arg Pro Lys Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His           
    130                 135                 140                           

aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc        480
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val           
145                 150                 155                 160           

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc        528
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
                165                 170                 175               

cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag        576
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
            180                 185                 190                   

gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag        624
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
        195                 200                 205                       

aca aag ccg cgg gag gag cag tac aac agc acg tac cgg gtg gtc agc        672
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
    210                 215                 220                           

gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag        720
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
225                 230                 235                 240           

tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc        768
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile           
                245                 250                 255               

tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc        816
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
            260                 265                 270                   

cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg        864
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
        275                 280                 285                       

gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat        912
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
    290                 295                 300                           

ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc        960
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
305                 310                 315                 320           

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg       1008
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
                325                 330                 335               

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg       1056
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
            340                 345                 350                   

cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa gtc       1104
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val           
        355                 360                 365                       

gac gag ggc ccg ggt gga ggc ggg tcg ggc ggt ggg gga tct ggg ggc       1152
Asp Glu Gly Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
    370                 375                 380                           

ggt gga tcc gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg       1200
Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro           
385                 390                 395                 400           

tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc       1248
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro           
                405                 410                 415               

cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca       1296
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr           
            420                 425                 430                   

tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac       1344
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn           
        435                 440                 445                       

tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg       1392
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg           
    450                 455                 460                           

gag gag cag tac aac agc acg tac cgg gtg gtc agc gtc ctc acc gtc       1440
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val           
465                 470                 475                 480           

ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc       1488
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser           
                485                 490                 495               

aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa       1536
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys           
            500                 505                 510                   

ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat       1584
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp           
        515                 520                 525                       

gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc       1632
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe           
    530                 535                 540                           

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag       1680
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
545                 550                 555                 560           

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc       1728
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
                565                 570                 575               

ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg       1776
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
            580                 585                 590                   

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac       1824
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
        595                 600                 605                       

acg cag aag agc ctc tcc ctg tct ccg ggt aaa gtc gac gag ggc ccg       1872
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Glu Gly Pro           
    610                 615                 620                           

gca ccc atg gca gaa gga gga ggg cag aat cat cac gaa gtg gtg aag       1920
Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys           
625                 630                 635                 640           

ttc atg gat gtc tat cag cgc agc tac tgc cat cca atc gag acc ctg       1968
Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu           
                645                 650                 655               

gtg gac atc ttc cag gag tac cct gat gag atc gag tac atc ttc aag       2016
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys           
            660                 665                 670                   

cca tcc tgt gtg ccc ctg atg cga tgc ggg ggc tgc tgc aat gac gag       2064
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu           
        675                 680                 685                       

ggc ctg gag tgt gtg ccc act gag gag tcc aac atc acc atg cag att       2112
Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile           
    690                 695                 700                           

atg cgg atc aaa cct cac caa ggc cag cac ata gga gag atg agc ttc       2160
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe           
705                 710                 715                 720           

cta cag cac aac aaa tgt gaa tgc aga cca aag aaa gat aga gca aga       2208
Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg           
                725                 730                 735               

caa gaa aat ccc tgt ggg cct tgc tca gag cgg aga aag cat ttg ttt       2256
Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe           
            740                 745                 750                   

gta caa gat ccg cag acg tgt aaa tgt tcc tgc aaa aac aca gac tcg       2304
Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser           
        755                 760                 765                       

cgt tgc aag gcg agg cag ctt gag tta aac gaa cgt act tgc aga tgt       2352
Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys           
    770                 775                 780                           

gac aag ccg agg cgg cac cac cac cac cac cac tga                       2388
Asp Lys Pro Arg Arg His His His His His His                               
785                 790                 795                               


<210>  11
<211>  795
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His 
    130                 135                 140                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
145                 150                 155                 160 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                165                 170                 175     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            180                 185                 190         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        195                 200                 205             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    210                 215                 220                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
225                 230                 235                 240 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                245                 250                 255     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            260                 265                 270         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        275                 280                 285             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    290                 295                 300                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
305                 310                 315                 320 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                325                 330                 335     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            340                 345                 350         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
        355                 360                 365             


Asp Glu Gly Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        515                 520                 525             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Glu Gly Pro 
    610                 615                 620                 


Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
625                 630                 635                 640 


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
                645                 650                 655     


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
            660                 665                 670         


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
        675                 680                 685             


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
    690                 695                 700                 


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
705                 710                 715                 720 


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
                725                 730                 735     


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
            740                 745                 750         


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
        755                 760                 765             


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
    770                 775                 780                 


Asp Lys Pro Arg Arg His His His His His His 
785                 790                 795 


