                         SEQUENCE LISTING

<110>  Flagship Ventures Management, Inc.
       von Maltzahn, Geoffrey
       Milwid, John Miles
       Mee, Michael
       Rubens, Jacob Rosenblum
       Chess, David
       Trudeau, Kyle
       Mahdaviani, Kiana
       Feala, Jacob
 
<120>  Methods and compositions of chondrisomes from cultured cells

<130>  V2050-7002WO(VL39003WO1)

<150>  62/261,157
<151>  2015-11-30

<150>  62/261,169
<151>  2015-11-30

<150>  62/261,170
<151>  2015-11-30

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  307
<212>  PRT
<213>  homo sapien

<400>  1

Met Gly Gly Leu Thr Ala Ser Asp Val His Pro Thr Leu Gly Val Gln 
1               5                   10                  15      


Leu Phe Ser Ala Gly Ile Ala Ala Cys Leu Ala Asp Val Ile Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Val Gln Gly Glu Cys Pro 
        35                  40                  45              


Thr Ser Ser Val Ile Arg Tyr Lys Gly Val Leu Gly Thr Ile Thr Ala 
    50                  55                  60                  


Val Val Lys Thr Glu Gly Arg Met Lys Leu Tyr Ser Gly Leu Pro Ala 
65                  70                  75                  80  


Gly Leu Gln Arg Gln Ile Ser Ser Ala Ser Leu Arg Ile Gly Leu Tyr 
                85                  90                  95      


Asp Thr Val Gln Glu Phe Leu Thr Ala Gly Lys Glu Thr Ala Pro Ser 
            100                 105                 110         


Leu Gly Ser Lys Ile Leu Ala Gly Leu Thr Thr Gly Gly Val Ala Val 
        115                 120                 125             


Phe Ile Gly Gln Pro Thr Glu Val Val Lys Val Arg Leu Gln Ala Gln 
    130                 135                 140                 


Ser His Leu His Gly Ile Lys Pro Arg Tyr Thr Gly Thr Tyr Asn Ala 
145                 150                 155                 160 


Tyr Arg Ile Ile Ala Thr Thr Glu Gly Leu Thr Gly Leu Trp Lys Gly 
                165                 170                 175     


Thr Thr Pro Asn Leu Met Arg Ser Val Ile Ile Asn Cys Thr Glu Leu 
            180                 185                 190         


Val Thr Tyr Asp Leu Met Lys Glu Ala Phe Val Lys Asn Asn Ile Leu 
        195                 200                 205             


Ala Asp Asp Val Pro Cys His Leu Val Ser Ala Leu Ile Ala Gly Phe 
    210                 215                 220                 


Cys Ala Thr Ala Met Ser Ser Pro Val Asp Val Val Lys Thr Arg Phe 
225                 230                 235                 240 


Ile Asn Ser Pro Pro Gly Gln Tyr Lys Ser Val Pro Asn Cys Ala Met 
                245                 250                 255     


Lys Val Phe Thr Asn Glu Gly Pro Thr Ala Phe Phe Lys Gly Leu Val 
            260                 265                 270         


Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val Ile Met Phe Val Cys 
        275                 280                 285             


Phe Glu Gln Leu Lys Arg Glu Leu Ser Lys Ser Arg Gln Thr Met Asp 
    290                 295                 300                 


Cys Ala Thr 
305         


<210>  2
<211>  309
<212>  PRT
<213>  homo sapien

<400>  2

Met Val Gly Phe Lys Ala Thr Asp Val Pro Pro Thr Ala Thr Val Lys 
1               5                   10                  15      


Phe Leu Gly Ala Gly Thr Ala Ala Cys Ile Ala Asp Leu Ile Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Ser Gln 
        35                  40                  45              


Gly Pro Val Arg Ala Thr Ala Ser Ala Gln Tyr Arg Gly Val Met Gly 
    50                  55                  60                  


Thr Ile Leu Thr Met Val Arg Thr Glu Gly Pro Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Gly Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Val Arg 
                85                  90                  95      


Ile Gly Leu Tyr Asp Ser Val Lys Gln Phe Tyr Thr Lys Gly Ser Glu 
            100                 105                 110         


His Ala Ser Ile Gly Ser Arg Leu Leu Ala Gly Ser Thr Thr Gly Ala 
        115                 120                 125             


Leu Ala Val Ala Val Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
    130                 135                 140                 


Gln Ala Gln Ala Arg Ala Gly Gly Gly Arg Arg Tyr Gln Ser Thr Val 
145                 150                 155                 160 


Asn Ala Tyr Lys Thr Ile Ala Arg Glu Glu Gly Phe Arg Gly Leu Trp 
                165                 170                 175     


Lys Gly Thr Ser Pro Asn Val Ala Arg Asn Ala Ile Val Asn Cys Ala 
            180                 185                 190         


Glu Leu Val Thr Tyr Asp Leu Ile Lys Asp Ala Leu Leu Lys Ala Asn 
        195                 200                 205             


Leu Met Thr Asp Asp Leu Pro Cys His Phe Thr Ser Ala Phe Gly Ala 
    210                 215                 220                 


Gly Phe Cys Thr Thr Val Ile Ala Ser Pro Val Asp Val Val Lys Thr 
225                 230                 235                 240 


Arg Tyr Met Asn Ser Ala Leu Gly Gln Tyr Ser Ser Ala Gly His Cys 
                245                 250                 255     


Ala Leu Thr Met Leu Gln Lys Glu Gly Pro Arg Ala Phe Tyr Lys Gly 
            260                 265                 270         


Phe Met Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val Val Met Phe 
        275                 280                 285             


Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Ala Ala Cys Thr Ser 
    290                 295                 300                 


Arg Glu Ala Pro Phe 
305                 


<210>  3
<211>  312
<212>  PRT
<213>  homo sapien

<400>  3

Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys 
1               5                   10                  15      


Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln 
        35                  40                  45              


Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr 
    50                  55                  60                  


Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly 
65                  70                  75                  80  


Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile 
                85                  90                  95      


Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp 
            100                 105                 110         


Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala 
        115                 120                 125             


Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
    130                 135                 140                 


Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser 
145                 150                 155                 160 


Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg 
                165                 170                 175     


Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val 
            180                 185                 190         


Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu 
        195                 200                 205             


Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala 
    210                 215                 220                 


Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val 
225                 230                 235                 240 


Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro 
                245                 250                 255     


Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe 
            260                 265                 270         


Tyr Lys Gly Phe Thr Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val 
        275                 280                 285             


Val Met Phe Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Lys Val 
    290                 295                 300                 


Gln Met Leu Arg Glu Ser Pro Phe 
305                 310         


<210>  4
<211>  323
<212>  PRT
<213>  homo sapien

<400>  4

Met Ser Val Pro Glu Glu Glu Glu Arg Leu Leu Pro Leu Thr Gln Arg 
1               5                   10                  15      


Trp Pro Arg Ala Ser Lys Phe Leu Leu Ser Gly Cys Ala Ala Thr Val 
            20                  25                  30          


Ala Glu Leu Ala Thr Phe Pro Leu Asp Leu Thr Lys Thr Arg Leu Gln 
        35                  40                  45              


Met Gln Gly Glu Ala Ala Leu Ala Arg Leu Gly Asp Gly Ala Arg Glu 
    50                  55                  60                  


Ser Ala Pro Tyr Arg Gly Met Val Arg Thr Ala Leu Gly Ile Ile Glu 
65                  70                  75                  80  


Glu Glu Gly Phe Leu Lys Leu Trp Gln Gly Val Thr Pro Ala Ile Tyr 
                85                  90                  95      


Arg His Val Val Tyr Ser Gly Gly Arg Met Val Thr Tyr Glu His Leu 
            100                 105                 110         


Arg Glu Val Val Phe Gly Lys Ser Glu Asp Glu His Tyr Pro Leu Trp 
        115                 120                 125             


Lys Ser Val Ile Gly Gly Met Met Ala Gly Val Ile Gly Gln Phe Leu 
    130                 135                 140                 


Ala Asn Pro Thr Asp Leu Val Lys Val Gln Met Gln Met Glu Gly Lys 
145                 150                 155                 160 


Arg Lys Leu Glu Gly Lys Pro Leu Arg Phe Arg Gly Val His His Ala 
                165                 170                 175     


Phe Ala Lys Ile Leu Ala Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly 
            180                 185                 190         


Trp Val Pro Asn Ile Gln Arg Ala Ala Leu Val Asn Met Gly Asp Leu 
        195                 200                 205             


Thr Thr Tyr Asp Thr Val Lys His Tyr Leu Val Leu Asn Thr Pro Leu 
    210                 215                 220                 


Glu Asp Asn Ile Met Thr His Gly Leu Ser Ser Leu Cys Ser Gly Leu 
225                 230                 235                 240 


Val Ala Ser Ile Leu Gly Thr Pro Ala Asp Val Ile Lys Ser Arg Ile 
                245                 250                 255     


Met Asn Gln Pro Arg Asp Lys Gln Gly Arg Gly Leu Leu Tyr Lys Ser 
            260                 265                 270         


Ser Thr Asp Cys Leu Ile Gln Ala Val Gln Gly Glu Gly Phe Met Ser 
        275                 280                 285             


Leu Tyr Lys Gly Phe Leu Pro Ser Trp Leu Arg Met Thr Pro Trp Ser 
    290                 295                 300                 


Met Val Phe Trp Leu Thr Tyr Glu Lys Ile Arg Glu Met Ser Gly Val 
305                 310                 315                 320 


Ser Pro Phe 
            


<210>  5
<211>  325
<212>  PRT
<213>  homo sapien

<400>  5

Met Gly Ile Phe Pro Gly Ile Ile Leu Ile Phe Leu Arg Val Lys Phe 
1               5                   10                  15      


Ala Thr Ala Ala Val Ile Val Ser Gly His Gln Lys Ser Thr Thr Val 
            20                  25                  30          


Ser His Glu Met Ser Gly Leu Asn Trp Lys Pro Phe Val Tyr Gly Gly 
        35                  40                  45              


Leu Ala Ser Ile Val Ala Glu Phe Gly Thr Phe Pro Val Asp Leu Thr 
    50                  55                  60                  


Lys Thr Arg Leu Gln Val Gln Gly Gln Ser Ile Asp Ala Arg Phe Lys 
65                  70                  75                  80  


Glu Ile Lys Tyr Arg Gly Met Phe His Ala Leu Phe Arg Ile Cys Lys 
                85                  90                  95      


Glu Glu Gly Val Leu Ala Leu Tyr Ser Gly Ile Ala Pro Ala Leu Leu 
            100                 105                 110         


Arg Gln Ala Ser Tyr Gly Thr Ile Lys Ile Gly Ile Tyr Gln Ser Leu 
        115                 120                 125             


Lys Arg Leu Phe Val Glu Arg Leu Glu Asp Glu Thr Leu Leu Ile Asn 
    130                 135                 140                 


Met Ile Cys Gly Val Val Ser Gly Val Ile Ser Ser Thr Ile Ala Asn 
145                 150                 155                 160 


Pro Thr Asp Val Leu Lys Ile Arg Met Gln Ala Gln Gly Ser Leu Phe 
                165                 170                 175     


Gln Gly Ser Met Ile Gly Ser Phe Ile Asp Ile Tyr Gln Gln Glu Gly 
            180                 185                 190         


Thr Arg Gly Leu Trp Arg Gly Val Val Pro Thr Ala Gln Arg Ala Ala 
        195                 200                 205             


Ile Val Val Gly Val Glu Leu Pro Val Tyr Asp Ile Thr Lys Lys His 
    210                 215                 220                 


Leu Ile Leu Ser Gly Met Met Gly Asp Thr Ile Leu Thr His Phe Val 
225                 230                 235                 240 


Ser Ser Phe Thr Cys Gly Leu Ala Gly Ala Leu Ala Ser Asn Pro Val 
                245                 250                 255     


Asp Val Val Arg Thr Arg Met Met Asn Gln Arg Ala Ile Val Gly His 
            260                 265                 270         


Val Asp Leu Tyr Lys Gly Thr Val Asp Gly Ile Leu Lys Met Trp Lys 
        275                 280                 285             


His Glu Gly Phe Phe Ala Leu Tyr Lys Gly Phe Trp Pro Asn Trp Leu 
    290                 295                 300                 


Arg Leu Gly Pro Trp Asn Ile Ile Phe Phe Ile Thr Tyr Glu Gln Leu 
305                 310                 315                 320 


Lys Arg Leu Gln Ile 
                325 


<210>  6
<211>  87
<212>  DNA
<213>  homo sapien

<400>  6
atgtccgtcc tgacgccgct gctgctgcgg ggcttgacag gctcggcccg gcggctccca       60

gtgccgcgcg ccaagatcca ttcgttg                                           87


<210>  7
<211>  257
<212>  PRT
<213>  homo sapien

<400>  7

Met Val Gly Ala Gly Ile Ser Thr Pro Ser Gly Ile Pro Asp Phe Arg 
1               5                   10                  15      


Ser Pro Gly Ser Gly Leu Tyr Ser Asn Leu Gln Gln Tyr Asp Leu Pro 
            20                  25                  30          


Tyr Pro Glu Ala Ile Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys 
        35                  40                  45              


Pro Phe Phe Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro 
    50                  55                  60                  


Asn Val Thr His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu 
65                  70                  75                  80  


Leu Arg Leu Tyr Thr Gln Asn Ile Asp Gly Leu Glu Arg Val Ser Gly 
                85                  90                  95      


Ile Pro Ala Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala 
            100                 105                 110         


Thr Cys Thr Val Cys Gln Arg Pro Phe Pro Gly Glu Asp Ile Arg Ala 
        115                 120                 125             


Asp Val Met Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val 
    130                 135                 140                 


Val Lys Pro Asp Ile Val Phe Phe Gly Glu Pro Leu Pro Gln Arg Phe 
145                 150                 155                 160 


Leu Leu His Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu Ile Leu 
                165                 170                 175     


Gly Thr Ser Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val 
            180                 185                 190         


Arg Ser Ser Val Pro Arg Leu Leu Ile Asn Arg Asp Leu Val Gly Pro 
        195                 200                 205             


Leu Ala Trp His Pro Arg Ser Arg Asp Val Ala Gln Leu Gly Asp Val 
    210                 215                 220                 


Val His Gly Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu 
225                 230                 235                 240 


Met Arg Asp Leu Val Gln Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp 
                245                 250                 255     


Lys 
    


<210>  8
<211>  436
<212>  PRT
<213>  homo sapien

<400>  8

Met Arg Leu Ala Arg Leu Leu Arg Gly Ala Ala Leu Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Leu Arg Ala Ala Gly Phe Ser Arg Ser Phe Ser Ser Asp Ser 
            20                  25                  30          


Gly Ser Ser Pro Ala Ser Glu Arg Gly Val Pro Gly Gln Val Asp Phe 
        35                  40                  45              


Tyr Ala Arg Phe Ser Pro Ser Pro Leu Ser Met Lys Gln Phe Leu Asp 
    50                  55                  60                  


Phe Gly Ser Val Asn Ala Cys Glu Lys Thr Ser Phe Met Phe Leu Arg 
65                  70                  75                  80  


Gln Glu Leu Pro Val Arg Leu Ala Asn Ile Met Lys Glu Ile Ser Leu 
                85                  90                  95      


Leu Pro Asp Asn Leu Leu Arg Thr Pro Ser Val Gln Leu Val Gln Ser 
            100                 105                 110         


Trp Tyr Ile Gln Ser Leu Gln Glu Leu Leu Asp Phe Lys Asp Lys Ser 
        115                 120                 125             


Ala Glu Asp Ala Lys Ala Ile Tyr Asp Phe Thr Asp Thr Val Ile Arg 
    130                 135                 140                 


Ile Arg Asn Arg His Asn Asp Val Ile Pro Thr Met Ala Gln Gly Val 
145                 150                 155                 160 


Ile Glu Tyr Lys Glu Ser Phe Gly Val Asp Pro Val Thr Ser Gln Asn 
                165                 170                 175     


Val Gln Tyr Phe Leu Asp Arg Phe Tyr Met Ser Arg Ile Ser Ile Arg 
            180                 185                 190         


Met Leu Leu Asn Gln His Ser Leu Leu Phe Gly Gly Lys Gly Lys Gly 
        195                 200                 205             


Ser Pro Ser His Arg Lys His Ile Gly Ser Ile Asn Pro Asn Cys Asn 
    210                 215                 220                 


Val Leu Glu Val Ile Lys Asp Gly Tyr Glu Asn Ala Arg Arg Leu Cys 
225                 230                 235                 240 


Asp Leu Tyr Tyr Ile Asn Ser Pro Glu Leu Glu Leu Glu Glu Leu Asn 
                245                 250                 255     


Ala Lys Ser Pro Gly Gln Pro Ile Gln Val Val Tyr Val Pro Ser His 
            260                 265                 270         


Leu Tyr His Met Val Phe Glu Leu Phe Lys Asn Ala Met Arg Ala Thr 
        275                 280                 285             


Met Glu His His Ala Asn Arg Gly Val Tyr Pro Pro Ile Gln Val His 
    290                 295                 300                 


Val Thr Leu Gly Asn Glu Asp Leu Thr Val Lys Met Ser Asp Arg Gly 
305                 310                 315                 320 


Gly Gly Val Pro Leu Arg Lys Ile Asp Arg Leu Phe Asn Tyr Met Tyr 
                325                 330                 335     


Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
            340                 345                 350         


Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr Ala Gln Tyr 
        355                 360                 365             


Phe Gln Gly Asp Leu Lys Leu Tyr Ser Leu Glu Gly Tyr Gly Thr Asp 
    370                 375                 380                 


Ala Val Ile Tyr Ile Lys Ala Leu Ser Thr Asp Ser Ile Glu Arg Leu 
385                 390                 395                 400 


Pro Val Tyr Asn Lys Ala Ala Trp Lys His Tyr Asn Thr Asn His Glu 
                405                 410                 415     


Ala Asp Asp Trp Cys Val Pro Ser Arg Glu Pro Lys Asp Met Thr Thr 
            420                 425                 430         


Phe Arg Ser Ala 
        435     


<210>  9
<211>  1046
<212>  PRT
<213>  homo sapien

<400>  9

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Glu Pro Thr Lys 
1               5                   10                  15      


Arg Met Leu Ser Phe Gln Gly Leu Ala Glu Leu Ala His Arg Glu Tyr 
            20                  25                  30          


Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gln Leu Trp 
        35                  40                  45              


Arg Gln Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser Ile 
    50                  55                  60                  


His Phe Gln Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 
65                  70                  75                  80  


Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly 
                85                  90                  95      


Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln Glu Ala Ile Glu His Tyr 
            100                 105                 110         


Arg His Ala Leu Arg Leu Lys Pro Asp Phe Ile Asp Gly Tyr Ile Asn 
        115                 120                 125             


Leu Ala Ala Ala Leu Val Ala Ala Gly Asp Met Glu Gly Ala Val Gln 
    130                 135                 140                 


Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro Asp Leu Tyr Cys Val Arg 
145                 150                 155                 160 


Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu Gly Arg Leu Glu Glu Ala 
                165                 170                 175     


Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr Gln Pro Asn Phe Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Leu Gly Cys Val Phe Asn Ala Gln Gly Glu Ile Trp 
        195                 200                 205             


Leu Ala Ile His His Phe Glu Lys Ala Val Thr Leu Asp Pro Asn Phe 
    210                 215                 220                 


Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val Leu Lys Glu Ala Arg Ile 
225                 230                 235                 240 


Phe Asp Arg Ala Val Ala Ala Tyr Leu Arg Ala Leu Ser Leu Ser Pro 
                245                 250                 255     


Asn His Ala Val Val His Gly Asn Leu Ala Cys Val Tyr Tyr Glu Gln 
            260                 265                 270         


Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr Arg Arg Ala Ile Glu Leu 
        275                 280                 285             


Gln Pro His Phe Pro Asp Ala Tyr Cys Asn Leu Ala Asn Ala Leu Lys 
    290                 295                 300                 


Glu Lys Gly Ser Val Ala Glu Ala Glu Asp Cys Tyr Asn Thr Ala Leu 
305                 310                 315                 320 


Arg Leu Cys Pro Thr His Ala Asp Ser Leu Asn Asn Leu Ala Asn Ile 
                325                 330                 335     


Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala Val Arg Leu Tyr Arg Lys 
            340                 345                 350         


Ala Leu Glu Val Phe Pro Glu Phe Ala Ala Ala His Ser Asn Leu Ala 
        355                 360                 365             


Ser Val Leu Gln Gln Gln Gly Lys Leu Gln Glu Ala Leu Met His Tyr 
    370                 375                 380                 


Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe Ala Asp Ala Tyr Ser Asn 
385                 390                 395                 400 


Met Gly Asn Thr Leu Lys Glu Met Gln Asp Val Gln Gly Ala Leu Gln 
                405                 410                 415     


Cys Tyr Thr Arg Ala Ile Gln Ile Asn Pro Ala Phe Ala Asp Ala His 
            420                 425                 430         


Ser Asn Leu Ala Ser Ile His Lys Asp Ser Gly Asn Ile Pro Glu Ala 
        435                 440                 445             


Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu Lys Pro Asp Phe Pro Asp 
    450                 455                 460                 


Ala Tyr Cys Asn Leu Ala His Cys Leu Gln Ile Val Cys Asp Trp Thr 
465                 470                 475                 480 


Asp Tyr Asp Glu Arg Met Lys Lys Leu Val Ser Ile Val Ala Asp Gln 
                485                 490                 495     


Leu Glu Lys Asn Arg Leu Pro Ser Val His Pro His His Ser Met Leu 
            500                 505                 510         


Tyr Pro Leu Ser His Gly Phe Arg Lys Ala Ile Ala Glu Arg His Gly 
        515                 520                 525             


Asn Leu Cys Leu Asp Lys Ile Asn Val Leu His Lys Pro Pro Tyr Glu 
    530                 535                 540                 


His Pro Lys Asp Leu Lys Leu Ser Asp Gly Arg Leu Arg Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ser Asp Phe Gly Asn His Pro Thr Ser His Leu Met Gln Ser 
                565                 570                 575     


Ile Pro Gly Met His Asn Pro Asp Lys Phe Glu Val Phe Cys Tyr Ala 
            580                 585                 590         


Leu Ser Pro Asp Asp Gly Thr Asn Phe Arg Val Lys Val Met Ala Glu 
        595                 600                 605             


Ala Asn His Phe Ile Asp Leu Ser Gln Ile Pro Cys Asn Gly Lys Ala 
    610                 615                 620                 


Ala Asp Arg Ile His Gln Asp Gly Ile His Ile Leu Val Asn Met Asn 
625                 630                 635                 640 


Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu Phe Ala Leu Arg Pro Ala 
                645                 650                 655     


Pro Ile Gln Ala Met Trp Leu Gly Tyr Pro Gly Thr Ser Gly Ala Leu 
            660                 665                 670         


Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu Thr Ser Pro Ala Glu Val 
        675                 680                 685             


Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr Met Pro His Thr Phe Phe 
    690                 695                 700                 


Ile Gly Asp His Ala Asn Met Phe Pro His Leu Lys Lys Lys Ala Val 
705                 710                 715                 720 


Ile Asp Phe Lys Ser Asn Gly His Ile Tyr Asp Asn Arg Ile Val Leu 
                725                 730                 735     


Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp Ser Leu Pro Asp Val Lys 
            740                 745                 750         


Ile Val Lys Met Lys Cys Pro Asp Gly Gly Asp Asn Ala Asp Ser Ser 
        755                 760                 765             


Asn Thr Ala Leu Asn Met Pro Val Ile Pro Met Asn Thr Ile Ala Glu 
    770                 775                 780                 


Ala Val Ile Glu Met Ile Asn Arg Gly Gln Ile Gln Ile Thr Ile Asn 
785                 790                 795                 800 


Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr Thr Gln Ile Asn Asn Lys 
                805                 810                 815     


Ala Ala Thr Gly Glu Glu Val Pro Arg Thr Ile Ile Val Thr Thr Arg 
            820                 825                 830         


Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile Val Tyr Cys Asn Phe Asn 
        835                 840                 845             


Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu Gln Met Trp Ala Asn Ile 
    850                 855                 860                 


Leu Lys Arg Val Pro Asn Ser Val Leu Trp Leu Leu Arg Phe Pro Ala 
865                 870                 875                 880 


Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala Gln Asn Met Gly Leu Pro 
                885                 890                 895     


Gln Asn Arg Ile Ile Phe Ser Pro Val Ala Pro Lys Glu Glu His Val 
            900                 905                 910         


Arg Arg Gly Gln Leu Ala Asp Val Cys Leu Asp Thr Pro Leu Cys Asn 
        915                 920                 925             


Gly His Thr Thr Gly Met Asp Val Leu Trp Ala Gly Thr Pro Met Val 
    930                 935                 940                 


Thr Met Pro Gly Glu Thr Leu Ala Ser Arg Val Ala Ala Ser Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala Lys Asn Arg Gln Glu Tyr 
                965                 970                 975     


Glu Asp Ile Ala Val Lys Leu Gly Thr Asp Leu Glu Tyr Leu Lys Lys 
            980                 985                 990         


Val Arg Gly Lys Val Trp Lys Gln  Arg Ile Ser Ser Pro  Leu Phe Asn 
        995                 1000                 1005             


Thr Lys  Gln Tyr Thr Met Glu  Leu Glu Arg Leu Tyr  Leu Gln Met 
    1010                 1015                 1020             


Trp Glu  His Tyr Ala Ala Gly  Asn Lys Pro Asp His  Met Ile Lys 
    1025                 1030                 1035             


Pro Val  Glu Val Thr Glu Ser  Ala 
    1040                 1045     


<210>  10
<211>  145
<212>  PRT
<213>  homo sapien

<400>  10

Met Asn Gly Arg Val Asp Tyr Leu Val Thr Glu Glu Glu Ile Asn Leu 
1               5                   10                  15      


Thr Arg Gly Pro Ser Gly Leu Gly Phe Asn Ile Val Gly Gly Thr Asp 
            20                  25                  30          


Gln Gln Tyr Val Ser Asn Asp Ser Gly Ile Tyr Val Ser Arg Ile Lys 
        35                  40                  45              


Glu Asn Gly Ala Ala Ala Leu Asp Gly Arg Leu Gln Glu Gly Asp Lys 
    50                  55                  60                  


Ile Leu Ser Val Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp 
65                  70                  75                  80  


Ala Val Asp Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val 
                85                  90                  95      


Gln His Arg Leu Gln Val Gln Asn Gly Pro Ile Gly His Arg Gly Glu 
            100                 105                 110         


Gly Asp Pro Ser Gly Ile Pro Ile Phe Met Val Leu Val Pro Val Phe 
        115                 120                 125             


Ala Leu Thr Met Val Ala Ala Trp Ala Phe Met Arg Tyr Arg Gln Gln 
    130                 135                 140                 


Leu 
145 


<210>  11
<211>  142
<212>  PRT
<213>  homo sapien

<400>  11

Met Ala Ala Ala Val Ala Ala Ala Gly Ala Gly Glu Pro Gln Ser Pro 
1               5                   10                  15      


Asp Glu Leu Leu Pro Lys Gly Asp Ala Glu Lys Pro Glu Glu Glu Leu 
            20                  25                  30          


Glu Glu Asp Asp Asp Glu Glu Leu Asp Glu Thr Leu Ser Glu Arg Leu 
        35                  40                  45              


Trp Gly Leu Thr Glu Met Phe Pro Glu Arg Val Arg Ser Ala Ala Gly 
    50                  55                  60                  


Ala Thr Phe Asp Leu Ser Leu Phe Val Ala Gln Lys Met Tyr Arg Phe 
65                  70                  75                  80  


Ser Arg Ala Ala Leu Trp Ile Gly Thr Thr Ser Phe Met Ile Leu Val 
                85                  90                  95      


Leu Pro Val Val Phe Glu Thr Glu Lys Leu Gln Met Glu Gln Gln Gln 
            100                 105                 110         


Gln Leu Gln Gln Arg Gln Ile Leu Leu Gly Pro Asn Thr Gly Leu Ser 
        115                 120                 125             


Gly Gly Met Pro Gly Ala Leu Pro Ser Leu Pro Gly Lys Ile 
    130                 135                 140         


<210>  12
<211>  171
<212>  PRT
<213>  homo sapien

<400>  12

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  13
<211>  172
<212>  PRT
<213>  homo sapien

<400>  13

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Gly Ile Arg His Arg Leu 
        35                  40                  45              


Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys Gly Leu 
65                  70                  75                  80  


Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu Ala Met 
            100                 105                 110         


Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg Asn Ala 
    130                 135                 140                 


Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp Gly Thr 
145                 150                 155                 160 


Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His 
                165                 170         


<210>  14
<211>  194
<212>  PRT
<213>  homo sapien

<400>  14

Met Ala Ala Ala Ala Pro Asn Ala Gly Gly Ser Ala Pro Glu Thr Ala 
1               5                   10                  15      


Gly Ser Ala Glu Ala Pro Leu Gln Tyr Ser Leu Leu Leu Gln Tyr Leu 
            20                  25                  30          


Val Gly Asp Lys Arg Gln Pro Arg Leu Leu Glu Pro Gly Ser Leu Gly 
        35                  40                  45              


Gly Ile Pro Ser Pro Ala Lys Ser Glu Glu Gln Lys Met Ile Glu Lys 
    50                  55                  60                  


Ala Met Glu Ser Cys Ala Phe Lys Ala Ala Leu Ala Cys Val Gly Gly 
65                  70                  75                  80  


Phe Val Leu Gly Gly Ala Phe Gly Val Phe Thr Ala Gly Ile Asp Thr 
                85                  90                  95      


Asn Val Gly Phe Asp Pro Lys Asp Pro Tyr Arg Thr Pro Thr Ala Lys 
            100                 105                 110         


Glu Val Leu Lys Asp Met Gly Gln Arg Gly Met Ser Tyr Ala Lys Asn 
        115                 120                 125             


Phe Ala Ile Val Gly Ala Met Phe Ser Cys Thr Glu Cys Leu Ile Glu 
    130                 135                 140                 


Ser Tyr Arg Gly Thr Ser Asp Trp Lys Asn Ser Val Ile Ser Gly Cys 
145                 150                 155                 160 


Ile Thr Gly Gly Ala Ile Gly Phe Arg Ala Gly Leu Lys Ala Gly Ala 
                165                 170                 175     


Ile Gly Cys Gly Gly Phe Ala Ala Phe Ser Ala Ala Ile Asp Tyr Tyr 
            180                 185                 190         


Leu Arg 
        


<210>  15
<211>  246
<212>  PRT
<213>  homo sapien

<400>  15

Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg 
1               5                   10                  15      


Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro 
            20                  25                  30          


Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser 
        35                  40                  45              


Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln 
    50                  55                  60                  


Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu 
65                  70                  75                  80  


Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys 
                85                  90                  95      


Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu 
            100                 105                 110         


Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser 
        115                 120                 125             


Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr 
    130                 135                 140                 


Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser 
145                 150                 155                 160 


Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp 
                165                 170                 175     


Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu 
            180                 185                 190         


Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu 
        195                 200                 205             


Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu 
    210                 215                 220                 


Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys 
225                 230                 235                 240 


Tyr Gly Ala Glu Glu Cys 
                245     


<210>  16
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  18
<211>  427
<212>  PRT
<213>  homo sapien

<400>  18

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
1               5                   10                  15      


Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
            20                  25                  30          


Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr 
        35                  40                  45              


Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala 
    50                  55                  60                  


Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly 
65                  70                  75                  80  


Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln 
                85                  90                  95      


Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly 
            100                 105                 110         


Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser 
        115                 120                 125             


Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His 
    130                 135                 140                 


Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro 
145                 150                 155                 160 


Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu 
                165                 170                 175     


Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His 
            180                 185                 190         


Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg 
        195                 200                 205             


Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala 
    210                 215                 220                 


Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val 
225                 230                 235                 240 


Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr 
                245                 250                 255     


Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln 
            260                 265                 270         


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp 
        275                 280                 285             


Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu 
    290                 295                 300                 


Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val 
305                 310                 315                 320 


Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val 
                325                 330                 335     


Leu Lys Asp Val Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val 
            340                 345                 350         


Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu 
        355                 360                 365             


Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ala Val Ser Leu Gly 
    370                 375                 380                 


His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His 
385                 390                 395                 400 


Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Ile Cys Asn Gly Gly 
                405                 410                 415     


Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu 
            420                 425         


<210>  19
<211>  327
<212>  PRT
<213>  homo sapien

<400>  19

Met Pro Ala Leu Leu Glu Arg Pro Lys Leu Ser Asn Ala Met Ala Arg 
1               5                   10                  15      


Ala Leu His Arg His Ile Met Met Glu Arg Glu Arg Lys Arg Gln Glu 
            20                  25                  30          


Glu Glu Glu Val Asp Lys Met Met Glu Gln Lys Met Lys Glu Glu Gln 
        35                  40                  45              


Glu Arg Arg Lys Lys Lys Glu Met Glu Glu Arg Met Ser Leu Glu Glu 
    50                  55                  60                  


Thr Lys Glu Gln Ile Leu Lys Leu Glu Glu Lys Leu Leu Ala Leu Gln 
65                  70                  75                  80  


Glu Glu Lys His Gln Leu Phe Leu Gln Leu Lys Lys Val Leu His Glu 
                85                  90                  95      


Glu Glu Lys Arg Arg Arg Lys Glu Gln Ser Asp Leu Thr Thr Leu Thr 
            100                 105                 110         


Ser Ala Ala Tyr Gln Gln Ser Leu Thr Val His Thr Gly Thr His Leu 
        115                 120                 125             


Leu Ser Met Gln Gly Ser Pro Gly Gly His Asn Arg Pro Gly Thr Leu 
    130                 135                 140                 


Met Ala Ala Asp Arg Ala Lys Gln Met Phe Gly Pro Gln Val Leu Thr 
145                 150                 155                 160 


Thr Arg His Tyr Val Gly Ser Ala Ala Ala Phe Ala Gly Thr Pro Glu 
                165                 170                 175     


His Gly Gln Phe Gln Gly Ser Pro Gly Gly Ala Tyr Gly Thr Ala Gln 
            180                 185                 190         


Pro Pro Pro His Tyr Gly Pro Thr Gln Pro Ala Tyr Ser Pro Ser Gln 
        195                 200                 205             


Gln Leu Arg Ala Pro Ser Ala Phe Pro Ala Val Gln Tyr Leu Ser Gln 
    210                 215                 220                 


Pro Gln Pro Gln Pro Tyr Ala Val His Gly His Phe Gln Pro Thr Gln 
225                 230                 235                 240 


Thr Gly Phe Leu Gln Pro Gly Gly Ala Leu Ser Leu Gln Lys Gln Met 
                245                 250                 255     


Glu His Ala Asn Gln Gln Thr Gly Phe Ser Asp Ser Ser Ser Leu Arg 
            260                 265                 270         


Pro Met His Pro Gln Ala Leu His Pro Ala Pro Gly Leu Leu Ala Ser 
        275                 280                 285             


Pro Gln Leu Pro Val Gln Met Gln Pro Ala Gly Lys Ser Gly Phe Ala 
    290                 295                 300                 


Ala Thr Ser Gln Pro Gly Pro Arg Leu Pro Phe Ile Gln His Ser Gln 
305                 310                 315                 320 


Asn Pro Arg Phe Tyr His Lys 
                325         


<210>  20
<211>  324
<212>  PRT
<213>  homo sapien

<400>  20

Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala 
1               5                   10                  15      


Ala Pro Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Thr Thr Gly Ser 
            20                  25                  30          


Gly Ala Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala 
        35                  40                  45              


Gly Gly Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys 
    50                  55                  60                  


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
65                  70                  75                  80  


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
                85                  90                  95      


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
            100                 105                 110         


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
        115                 120                 125             


Gly Gly Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His 
    130                 135                 140                 


Tyr Arg Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln 
145                 150                 155                 160 


Asn Tyr Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser 
                165                 170                 175     


Ala Pro Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg 
            180                 185                 190         


Phe Pro Pro Tyr Tyr Met Arg Arg Pro Tyr Gly Arg Arg Pro Gln Tyr 
        195                 200                 205             


Ser Asn Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln 
    210                 215                 220                 


Gly Ala Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly 
225                 230                 235                 240 


Tyr Arg Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg 
                245                 250                 255     


Glu Asp Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln 
            260                 265                 270         


Gly Gln Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg 
        275                 280                 285             


Arg Arg Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys 
    290                 295                 300                 


Ala Ala Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln 
305                 310                 315                 320 


Gly Gly Ala Glu 
                


<210>  21
<211>  960
<212>  PRT
<213>  homo sapien

<400>  21

Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser 
1               5                   10                  15      


Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys 
            20                  25                  30          


Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu 
        35                  40                  45              


Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser 
    50                  55                  60                  


Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr 
65                  70                  75                  80  


Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala Thr Arg 
                85                  90                  95      


Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly Gly Gly 
            100                 105                 110         


Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile Pro Asp 
        115                 120                 125             


Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu Ile Asp 
    130                 135                 140                 


Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Ser Ser Glu 
145                 150                 155                 160 


Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu Ser Leu 
                165                 170                 175     


Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu Thr Ala 
            180                 185                 190         


Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe Arg Lys 
        195                 200                 205             


Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln Glu Glu Leu Leu His 
    210                 215                 220                 


Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg Leu Glu Lys Glu Asn 
225                 230                 235                 240 


Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp Asp Lys Gly Ile His 
                245                 250                 255     


His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met Tyr Ser Glu Val Leu 
            260                 265                 270         


Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn Thr Gln Asp His Leu 
        275                 280                 285             


Pro Arg Val Val Val Val Gly Asp Gln Ser Ala Gly Lys Thr Ser Val 
    290                 295                 300                 


Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro Arg Gly Ser Gly Glu 
305                 310                 315                 320 


Met Met Thr Arg Ser Pro Val Lys Val Thr Leu Ser Glu Gly Pro His 
                325                 330                 335     


His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu Phe Asp Leu Thr Lys 
            340                 345                 350         


Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile Glu Leu Arg Met Arg 
        355                 360                 365             


Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro Glu Thr Ile Ser Leu 
    370                 375                 380                 


Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val Leu Val Asp Leu Pro 
385                 390                 395                 400 


Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala Pro Asp Thr Lys Glu 
                405                 410                 415     


Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln Asn Pro Asn Ala Ile 
            420                 425                 430         


Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala Glu Arg Ser Ile Val 
        435                 440                 445             


Thr Asp Leu Val Ser Gln Met Asp Pro His Gly Arg Arg Thr Ile Phe 
    450                 455                 460                 


Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn Val Ala Ser Pro Ser 
465                 470                 475                 480 


Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe Pro Met Lys Ala Leu 
                485                 490                 495     


Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn Ser Ser Glu Ser Ile 
            500                 505                 510         


Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe Gln Asn Ser Lys Leu 
        515                 520                 525             


Leu Lys Thr Ser Met Leu Lys Ala His Gln Val Thr Thr Arg Asn Leu 
    530                 535                 540                 


Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met Val Arg Glu Ser Val 
545                 550                 555                 560 


Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg Phe Asn Leu Glu Thr 
                565                 570                 575     


Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu Leu Asp Arg Asn Glu 
            580                 585                 590         


Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp Glu Val Ile Ser Leu 
        595                 600                 605             


Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile Leu Gln Gln Ser Leu 
    610                 615                 620                 


Trp Glu Arg Val Ser Thr His Val Ile Glu Asn Ile Tyr Leu Pro Ala 
625                 630                 635                 640 


Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp Ile Lys 
                645                 650                 655     


Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val Glu Val 
            660                 665                 670         


Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg Phe Met Thr Glu Pro 
        675                 680                 685             


Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu Ala Val 
    690                 695                 700                 


Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala Glu Asp 
705                 710                 715                 720 


Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser Ile Ser 
                725                 730                 735     


Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu Ala Leu 
            740                 745                 750         


Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met Val Gly 
        755                 760                 765             


Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn Arg Thr Gln Glu 
    770                 775                 780                 


Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met Leu Lys 
785                 790                 795                 800 


Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile Thr Thr 
                805                 810                 815     


Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro Ser Leu 
            820                 825                 830         


Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His Phe Leu Lys Thr 
        835                 840                 845             


Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr Tyr Gln 
    850                 855                 860                 


Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp Val Val Leu Phe 
865                 870                 875                 880 


Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu Arg Gln 
                885                 890                 895     


Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val Lys Glu 
            900                 905                 910         


Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys Ile Lys Leu Leu 
        915                 920                 925             


Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val Arg Glu 
    930                 935                 940                 


Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln Glu Lys 
945                 950                 955                 960 


<210>  22
<211>  741
<212>  PRT
<213>  homo sapien

<400>  22

Met Ala Glu Pro Val Ser Pro Leu Lys His Phe Val Leu Ala Lys Lys 
1               5                   10                  15      


Ala Ile Thr Ala Ile Phe Asp Gln Leu Leu Glu Phe Val Thr Glu Gly 
            20                  25                  30          


Ser His Phe Val Glu Ala Thr Tyr Lys Asn Pro Glu Leu Asp Arg Ile 
        35                  40                  45              


Ala Thr Glu Asp Asp Leu Val Glu Met Gln Gly Tyr Lys Asp Lys Leu 
    50                  55                  60                  


Ser Ile Ile Gly Glu Val Leu Ser Arg Arg His Met Lys Val Ala Phe 
65                  70                  75                  80  


Phe Gly Arg Thr Ser Ser Gly Lys Ser Ser Val Ile Asn Ala Met Leu 
                85                  90                  95      


Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His Ile Thr Asn Cys Phe 
            100                 105                 110         


Leu Ser Val Glu Gly Thr Asp Gly Asp Lys Ala Tyr Leu Met Thr Glu 
        115                 120                 125             


Gly Ser Asp Glu Lys Lys Ser Val Lys Thr Val Asn Gln Leu Ala His 
    130                 135                 140                 


Ala Leu His Met Asp Lys Asp Leu Lys Ala Gly Cys Leu Val Arg Val 
145                 150                 155                 160 


Phe Trp Pro Lys Ala Lys Cys Ala Leu Leu Arg Asp Asp Leu Val Leu 
                165                 170                 175     


Val Asp Ser Pro Gly Thr Asp Val Thr Thr Glu Leu Asp Ser Trp Ile 
            180                 185                 190         


Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val Leu Val Ala Asn Ser 
        195                 200                 205             


Glu Ser Thr Leu Met Asn Thr Glu Lys His Phe Phe His Lys Val Asn 
    210                 215                 220                 


Glu Arg Leu Ser Lys Pro Asn Ile Phe Ile Leu Asn Asn Arg Trp Asp 
225                 230                 235                 240 


Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Asp Val Arg Arg Gln His 
                245                 250                 255     


Met Glu Arg Cys Leu His Phe Leu Val Glu Glu Leu Lys Val Val Asn 
            260                 265                 270         


Ala Leu Glu Ala Gln Asn Arg Ile Phe Phe Val Ser Ala Lys Glu Val 
        275                 280                 285             


Leu Ser Ala Arg Lys Gln Lys Ala Gln Gly Met Pro Glu Ser Gly Val 
    290                 295                 300                 


Ala Leu Ala Glu Gly Phe His Ala Arg Leu Gln Glu Phe Gln Asn Phe 
305                 310                 315                 320 


Glu Gln Ile Phe Glu Glu Cys Ile Ser Gln Ser Ala Val Lys Thr Lys 
                325                 330                 335     


Phe Glu Gln His Thr Ile Arg Ala Lys Gln Ile Leu Ala Thr Val Lys 
            340                 345                 350         


Asn Ile Met Asp Ser Val Asn Leu Ala Ala Glu Asp Lys Arg His Tyr 
        355                 360                 365             


Ser Val Glu Glu Arg Glu Asp Gln Ile Asp Arg Leu Asp Phe Ile Arg 
    370                 375                 380                 


Asn Gln Met Asn Leu Leu Thr Leu Asp Val Lys Lys Lys Ile Lys Glu 
385                 390                 395                 400 


Val Thr Glu Glu Val Ala Asn Lys Val Ser Cys Ala Met Thr Asp Glu 
                405                 410                 415     


Ile Cys Arg Leu Ser Val Leu Val Asp Glu Phe Cys Ser Glu Phe His 
            420                 425                 430         


Pro Asn Pro Asp Val Leu Lys Ile Tyr Lys Ser Glu Leu Asn Lys His 
        435                 440                 445             


Ile Glu Asp Gly Met Gly Arg Asn Leu Ala Asp Arg Cys Thr Asp Glu 
    450                 455                 460                 


Val Asn Ala Leu Val Leu Gln Thr Gln Gln Glu Ile Ile Glu Asn Leu 
465                 470                 475                 480 


Lys Pro Leu Leu Pro Ala Gly Ile Gln Asp Lys Leu His Thr Leu Ile 
                485                 490                 495     


Pro Cys Lys Lys Phe Asp Leu Ser Tyr Asn Leu Asn Tyr His Lys Leu 
            500                 505                 510         


Cys Ser Asp Phe Gln Glu Asp Ile Val Phe Pro Phe Ser Leu Gly Trp 
        515                 520                 525             


Ser Ser Leu Val His Arg Phe Leu Gly Pro Arg Asn Ala Gln Arg Val 
    530                 535                 540                 


Leu Leu Gly Leu Ser Glu Pro Ile Phe Gln Leu Pro Arg Ser Leu Ala 
545                 550                 555                 560 


Ser Thr Pro Thr Ala Pro Thr Thr Pro Ala Thr Pro Asp Asn Ala Ser 
                565                 570                 575     


Gln Glu Glu Leu Met Ile Thr Leu Val Thr Gly Leu Ala Ser Val Thr 
            580                 585                 590         


Ser Arg Thr Ser Met Gly Ile Ile Ile Val Gly Gly Val Ile Trp Lys 
        595                 600                 605             


Thr Ile Gly Trp Lys Leu Leu Ser Val Ser Leu Thr Met Tyr Gly Ala 
    610                 615                 620                 


Leu Tyr Leu Tyr Glu Arg Leu Ser Trp Thr Thr His Ala Lys Glu Arg 
625                 630                 635                 640 


Ala Phe Lys Gln Gln Phe Val Asn Tyr Ala Thr Glu Lys Leu Arg Met 
                645                 650                 655     


Ile Val Ser Ser Thr Ser Ala Asn Cys Ser His Gln Val Lys Gln Gln 
            660                 665                 670         


Ile Ala Thr Thr Phe Ala Arg Leu Cys Gln Gln Val Asp Ile Thr Gln 
        675                 680                 685             


Lys Gln Leu Glu Glu Glu Ile Ala Arg Leu Pro Lys Glu Ile Asp Gln 
    690                 695                 700                 


Leu Glu Lys Ile Gln Asn Asn Ser Lys Leu Leu Arg Asn Lys Ala Val 
705                 710                 715                 720 


Gln Leu Glu Asn Glu Leu Glu Asn Phe Thr Lys Gln Phe Leu Pro Ser 
                725                 730                 735     


Ser Asn Glu Glu Ser 
            740     


<210>  23
<211>  757
<212>  PRT
<213>  homo sapien

<400>  23

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


